| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 3. |
- Takeuchi, Fumihiko, et al.
(författare)
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Interethnic analyses of blood pressure loci in populations of East Asian and European descent
- 2018
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
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| 4. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:10, s. 1113-1120
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Forskningsöversikt (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 5. |
- Demerath, Ellen W., et al.
(författare)
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Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
- 2015
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:15, s. 4464-4479
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may point to genomic pathways that are dysregulated in numerous conditions. The Illumina 450K Bead Chip array was used to assay DNA methylation in leukocyte DNA obtained from 2097 African American adults in the Atherosclerosis Risk in Communities (ARIC) study. Mixed-effects regression models were used to test the association of methylation beta value with concurrent body mass index (BMI) and waist circumference (WC), and BMI change, adjusting for batch effects and potential confounders. Replication using whole-blood DNA from 2377 White adults in the Framingham Heart Study and CD4+ T cell DNA from 991 Whites in the Genetics of Lipid Lowering Drugs and Diet Network Study was followed by testing using adipose tissue DNA from 648 women in the Multiple Tissue Human Expression Resource cohort. Seventy-six BMI-related probes, 164 WC-related probes and 8 BMI change-related probes passed the threshold for significance in ARIC (P < 1 x 10(-7); Bonferroni), including probes in the recently reported HIF3A, CPT1A and ABCG1 regions. Replication using blood DNA was achieved for 37 BMI probes and 1 additional WC probe. Sixteen of these also replicated in adipose tissue, including 15 novel methylation findings near genes involved in lipid metabolism, immune response/cytokine signaling and other diverse pathways, including LGALS3BP, KDM2B, PBX1 and BBS2, among others. Adiposity traits are associated with DNA methylation at numerous CpG sites that replicate across studies despite variation in tissue type, ethnicity and analytic approaches.
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| 6. |
- Shrine, Nick, et al.
(författare)
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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
- 2019
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 51:3, s. 481-493
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Tidskriftsartikel (refereegranskat)abstract
- Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
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| 7. |
- Watts, Anna L., et al.
(författare)
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Dense matter with eXTP
- 2019
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Ingår i: Science China Physics, Mechanics & Astronomy. - : Science Press. - 1674-7348 .- 1869-1927. ; 62:2
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Forskningsöversikt (refereegranskat)abstract
- In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry (eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s.
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| 8. |
- Zhang, Kaicheng, et al.
(författare)
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SN 2014J in M82 : new insights on the spectral diversity of Type Ia supernovae
- 2018
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 481:1, s. 878-893
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Tidskriftsartikel (refereegranskat)abstract
- We present extensive spectroscopic observations for one of the closest Type Ia supernovae (SNe Ia), SN 2014J discovered in M82, ranging from 10.4 d before to 473.2 d after B-band maximum light. The diffuse interstellar band features detected in a high-resolution spectrum allow an estimate of line-of-sight extinction as A(v) similar to 1.9 +/- 0.6 mag. Spectroscopically, SN 2014J can be put into the high-velocity (HV) subgroup in Wang's classification with a velocity of Si II lambda 6355 at maximum light of upsilon(0) = 1.22 +/- 0.01 x 10(4) km s(-1) but has a low velocity gradient (LVG, following Benetti's classification) of (v) over bar = 41 +/- 2 km s(-1) d(-1), which is inconsistent with the trend that HV SNe Ia generally have larger velocity gradients. We find that the HV SNe Ia with LVGs tend to have relatively stronger Si III (at similar to 4400 angstrom) absorptions in early spectra, larger ratios of S II lambda 5468 to S II lambda 5640, and weaker Si II 5972 absorptions compared to their counterparts with similar velocities but high velocity gradients. This shows that the HV+ LVG subgroup of SNe Ia may have intrinsically higher photospheric temperature, which indicates that their progenitors may experience more complete burning in the explosions relative to the typical HV SNe Ia.
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| 9. |
- Arcavi, Iair, et al.
(författare)
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Energetic eruptions leading to a peculiar hydrogen-rich explosion of a massive star
- 2017
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 551:7679, s. 210-213
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Tidskriftsartikel (refereegranskat)abstract
- Every supernova so far observed has been considered to be the terminal explosion of a star. Moreover, all supernovae with absorption lines in their spectra show those lines decreasing in velocity over time, as the ejecta expand and thin, revealing slower-moving material that was previously hidden. In addition, every supernova that exhibits the absorption lines of hydrogen has one main light-curve peak, or a plateau in luminosity, lasting approximately 100 days before declining(1). Here we report observations of iPTF14hls, an event that has spectra identical to a hydrogen-rich core-collapse supernova, but characteristics that differ extensively from those of known supernovae. The light curve has at least five peaks and remains bright for more than 600 days; the absorption lines show little to no decrease in velocity; and the radius of the line-forming region is more than an order of magnitude bigger than the radius of the photosphere derived from the continuum emission. These characteristics are consistent with a shell of several tens of solar masses ejected by the progenitor star at supernova-level energies a few hundred days before a terminal explosion. Another possible eruption was recorded at the same position in 1954. Multiple energetic pre-supernova eruptions are expected to occur in stars of 95 to 130 solar masses, which experience the pulsational pair instability(2-5). That model, however, does not account for the continued presence of hydrogen, or the energetics observed here. Another mechanism for the violent ejection of mass in massive stars may be required.
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| 10. |
- Li, Danqin, et al.
(författare)
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n-Doping of photoactive layer in binary organic solar cells realizes over 18.3% efficiency
- 2022
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Ingår i: Nano Energy. - : ELSEVIER. - 2211-2855 .- 2211-3282. ; 96
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Tidskriftsartikel (refereegranskat)abstract
- Electronic doping of conjugated semiconductor plays a critical role in the fabrication of high efficiency organic optoelectronic devices. Here, we report an organic solar cell (OSC) by doping n-type DMBI-BDZC into one host binary bulk heterojunction (BHJ) photoactive layer comprised of a polymer donor PM6 and a nonfullerene acceptor Y6. The resulting champion device yields a significantly improved power conversion efficiency from 17.17% to 18.33% with an impressive fill factor of 80.20%. It is found that the electrically doped photoactive layer exhibits enhanced and balanced charge carrier mobilities, more effective exciton dissociation, longer carrier lifetime, and suppressed charge recombination with smaller energy loss. The dopant molecule DMBIBDZC also act as a surface morphology modifier of the photoactive layer with enhanced charge transport. This work demonstrates that manipulation of charge transport via adding a low concentration dopant into photoactive layer is a promising approach for further improvement of BHJ OSC performance.
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| 11. |
- Merino, Jordi, et al.
(författare)
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Polygenic scores, diet quality, and type 2 diabetes risk : An observational study among 35,759 adults from 3 US cohorts
- 2022
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Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 19:4
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Tidskriftsartikel (refereegranskat)abstract
- Background Bothgenetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes. Methods and findings We analyzed data from 35,759 men and women in the United States participating in the Nurses’ Health Study (NHS) I (1986 to 2016) and II (1991 to 2017) and the Health Professionals Follow-up Study (HPFS; 1986 to 2016) with available genetic data and who did not have diabetes, cardiovascular disease, or cancer at baseline. Genetic risk was characterized using both a global polygenic score capturing overall genetic risk and pathway-specific polygenic scores denoting distinct pathophysiological mechanisms. Diet quality was assessed using the Alternate Healthy Eating Index (AHEI). Cox models were used to calculate hazard ratios (HRs) for type 2 diabetes after adjusting for potential confounders. WAU ith: Pleas over 902,386 person-years of follow-up, 4,433 participants were diagnosed with type 2 diabetes. The relative risk of type 2 diabetes was 1.29 (95% confidence interval [CI] 1.25, 1.32; P < 0.001) per standard deviation (SD) increase in global polygenic score and 1.13 (1.09, 1.17; P < 0.001) per 10-unit decrease in AHEI. Irrespective of genetic risk, low diet quality, as compared to high diet quality, was associated with approximately 30% increased risk of type 2 diabetes (Pinteraction = 0.69). The joint association of low diet quality and increased genetic risk was similar to the sum of the risk associated with each factor alone (Pinteraction = 0.30). Limitations of this study include the self-report of diet information and possible bias resulting from inclusion of highly educated participants with available genetic data. Conclusions These data provide evidence for the independent associations of genetic risk and diet quality with incident type 2 diabetes and suggest that a healthy diet is associated with lower diabetes risk across all levels of genetic risk.
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| 12. |
- Qi, Qibin, et al.
(författare)
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FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:25, s. 6961-6972
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Tidskriftsartikel (refereegranskat)abstract
- FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
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| 13. |
- Schunkert, Heribert, et al.
(författare)
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:4, s. 153-333
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Tidskriftsartikel (refereegranskat)abstract
- We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
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| 14. |
- Tong, Yang, et al.
(författare)
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Progress of the key materials for organic solar cells
- 2020
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Ingår i: Science in China Series B. - Beijing, China : SCIENCE PRESS. - 1674-7291 .- 1869-1870. ; 63:6, s. 758-765
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Forskningsöversikt (refereegranskat)abstract
- Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight, flexibility and roll-to-roll fabrication. Nowadays, 18% power conversion efficiency has been achieved in the state-of-the-art organic solar cells. The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies, and the deep understanding on film morphology, molecular packing and device physics. Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance. The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors. In this review, we focus on those star materials and milestone work, and introduce the molecular structure evolution of key materials. These key materials include homopolymer donors, D-A copolymer donors, A-D-A small molecular donors, fullerene acceptors and nonfullerene acceptors. At last, we outlook the challenges and very important directions in key materials development.
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| 15. |
- Zhao, Yaofeng, et al.
(författare)
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Ornithorhynchus anatinus (Platypus) Links the Evolution of Immunoglobulin Genes in Eutherian Mammals and Nonmammalian Tetrapods
- 2009
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 183:5, s. 3285-3293
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Tidskriftsartikel (refereegranskat)abstract
- The evolutionary origins of mammalian immunoglobulin H chain isotypes (IgM, IgD, IgG, IgE, and IgA) are still incompletely understood as these isotypes differ considerably in structure and number from their counterparts in nonmammalian tetrapods. We report in this study that the platypus (Ornithorhynchus anatinus) Ig H chain constant region gene locus contains eight Ig encoding genes, which are arranged in an mu-delta-o-gamma 2-gamma 1-alpha 1-epsilon-alpha 2 order, spanning a total of similar to 200 kb DNA, encoding six distinct isotypes. The o (o for Ornithorhynchus) gene encodes a novel Ig H chain isotype that consists of four constant region domains and a hinge, and is structurally different from any of the five known mammalian Ig classes. This gene is phylogenetically related to nu (epsilon) and gamma, and thus appears to be a structural intermediate between these two genes. The platypus delta gene encodes ten heavy chain constant region domains, lacks a hinge region and is similar to IgD in amphibians and fish, but strikingly different from that in eutherian mammals. The platypus Ig H chain isotype repertoire thus shows a unique combination of genes that share similarity both to those of nonmammallian tetrapods and eutherian animals and demonstrates how phylogenetically informative species can be used to reconstruct the evolutionary history of functionally important genes.
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| 16. |
- Andrews, Jennifer E., et al.
(författare)
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SN 2017gmr : An Energetic Type II-P Supernova with Asymmetries
- 2019
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 885:1
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Tidskriftsartikel (refereegranskat)abstract
- We present high-cadence UV, optical, and near-infrared data on the luminous Type II-P supernova SN;2017gmr from hours after discovery through the first 180 days. SN;2017gmr does not show signs of narrow, high-ionization emission lines in the early optical spectra, yet the optical light-curve evolution suggests that an extra energy source from circumstellar medium (CSM) interaction must be present for at least 2 days after explosion. Modeling of the early light curve indicates a ?500 R progenitor radius, consistent with a rather compact red supergiant, and late-time luminosities indicate that up to 0.130;;0.026 M of Ni-56 are present, if the light curve is solely powered by radioactive decay, although the Ni-56 mass may be lower if CSM interaction contributes to the post-plateau luminosity. Prominent multipeaked emission lines of H? and [O i] emerge after day 154, as a result of either an asymmetric explosion or asymmetries in the CSM. The lack of narrow lines within the first 2 days of explosion in the likely presence of CSM interaction may be an example of close, dense, asymmetric CSM that is quickly enveloped by the spherical supernova ejecta.
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| 17. |
- Assimes, Themistocles L., et al.
(författare)
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Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
- 2010
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 56:19, s. 1552-1563
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Tidskriftsartikel (refereegranskat)abstract
- Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
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| 18. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 19. |
- Cai, Liming, et al.
(författare)
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Optimal control of a malaria model with asymptomatic class and superinfection
- 2017
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Ingår i: Mathematical Biosciences. - : Elsevier BV. - 0025-5564 .- 1879-3134. ; 288, s. 94-108
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we introduce a malaria model with an asymptomatic class in human population and exposed classes in both human and vector populations. The model assumes that asymptomatic individuals can get re-infected and move to the symptomatic class. In the case of an incomplete treatment, symptomatic individuals move to the asymptomatic class. If successfully treated, the symptomatic individuals recover and move to the susceptible class. The basic reproduction number, R0,R0, is computed using the next generation approach. The system has a disease-free equilibrium (DFE) which is locally asymptomatically stable when R0<1,R0<1, and may have up to four endemic equilibria. The model exhibits backward bifurcation generated by two mechanisms; standard incidence and superinfection. If the model does not allow for superinfection or deaths due to the disease, then DFE is globally stable which suggests that backward bifurcation is no longer possible. Simulations suggest that total prevalence of malaria is the highest if all individuals show symptoms upon infection, but then undergoes an incomplete treatment and the lowest when all the individuals first move to the symptomatic class then treated successfully. Total prevalence is average if more individuals upon infection move to the asymptomatic class. We study optimal control strategies applied to bed-net use and treatment as main tools for reducing the total number of symptomatic and asymptomatic individuals. Simulations suggest that the optimal control strategies are very dynamic. Although they always lead to decrease in the symptomatic infectious individuals, they may lead to increase in the number of asymptomatic infectious individuals. This last scenario occurs if a large portion of newly infected individuals move to the symptomatic class but many of them do not complete treatment or if they all complete treatment but the superinfection rate of asymptomatic individuals is average.
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| 20. |
- Du, Kun, et al.
(författare)
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Effects of the layout of film holes near the vane leading edge on the endwall cooling and phantom cooling of the vane suction side surface
- 2017
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Ingår i: Numerical Heat Transfer; Part A: Applications. - : Informa UK Limited. - 1040-7782 .- 1521-0634. ; 71:9, s. 910-927
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Tidskriftsartikel (refereegranskat)abstract
- In the current research, effects of the layout of film holes near the first-stage vane leading edge on the endwall cooling and phantom cooling of the vane suction side surface were numerically studied. The computational results indicate that the case with a positive film-hole angle achieves a higher cooling effectiveness level on the endwall and vane suction side surface compared to the case with a corresponding negative film-hole angle. Furthermore, the location of the film hole has a significant influence on the cooling performance of the endwall and vane suction side surface. In addition, the case with a smaller distance from film holes to the vane stagnation also attains a slightly higher cooling effectiveness (phantom cooling effectiveness) on the vane suction side surface.
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| 21. |
- Du, Kun, et al.
(författare)
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Effects of the mainstream turbulence intensity and slot injection angle on the endwall cooling and phantom cooling of the vane suction side surface
- 2017
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Ingår i: International Journal of Heat and Mass Transfer. - : Elsevier BV. - 0017-9310. ; 112, s. 427-440
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Tidskriftsartikel (refereegranskat)abstract
- In order to obtain better performance, gas turbines always operate with high inlet temperature. This contributes to a high level of thermal load on the first stage vane endwall. To ensure safe operation of a gas turbine within a proper temperature range, the cooling performance of the vane endwall must be further investigated. In the present study, effects of the mainstream turbulence and upstream coolant flow direction on the endwall cooling and vane suction side surface phantom cooling were numerically investigated. Three-dimensional (3D) Reynolds-averaged Navier–Stokes (RANS) equations combined with shear stress transport (SST) k-ω turbulence model were solved to conduct the numerical simulations on basis of the validated turbulence model. The calculated results indicate that both the adiabatic cooling effectiveness on the endwall and the phantom cooling effectiveness on the vane suction side surface are significantly influenced by slot injection angle. For α=-30°, the coolant injection is driven towards the vane suction side, which contributes to the lowest adiabatic cooling effectiveness level on the pressure side endwall and the highest phantom cooling effectiveness level on the vane suction side surface. With the increase of the slot injection angle, the adiabatic cooling effectiveness level on the pressure side endwall is enhanced significantly. In contrast, the phantom cooling (when the vane suction side is cooled by coolant originating from the endwall) of the vane suction side surface is reduced significantly. This is because a large slot injection angle leads to a large coolant momentum towards the pressure side. Moreover, the case with a smaller slot injection angle obtains a slightly higher area-averaged adiabatic cooling effectiveness level around the leading edge due to a relatively larger portion of coolant being confined near the leading edge. In addition, the inlet turbulence intensity has a small impact on the overall endwall cooling and the phantom cooling of the vane suction side surface compared to the slot injection angle.
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| 22. |
- Freitag, Daniel F., et al.
(författare)
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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
- 2015
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Ingår i: The Lancet Diabetes & Endocrinology. - 2213-8595. ; 3:4, s. 243-253
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Tidskriftsartikel (refereegranskat)abstract
- Background To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor of both IL-1 alpha and IL-1 beta); both alleles increase soluble IL-1Ra protein concentration. We compared effects on inflammation biomarkers of this genetic score with those of anakinra, the recombinant form of IL-1Ra, which has previously been studied in randomised trials of rheumatoid arthritis and other inflammatory disorders. In primary analyses, we investigated the score in relation to rheumatoid arthritis and four cardiometabolic diseases (type 2 diabetes, coronary heart disease, ischaemic stroke, and abdominal aortic aneurysm; 453 411 total participants). In exploratory analyses, we studied the relation of the score to many disease traits and to 24 other disorders of proposed relevance to IL-1 signalling (746 171 total participants). Findings For each IL1RN minor allele inherited, serum concentrations of IL-1Ra increased by 0.22 SD (95% CI 0.18-0.25; 12.5%; p=9.3 x 10(-33)), concentrations of interleukin 6 decreased by 0.02 SD (-0.04 to -0.01; -1,7%; p=3.5 x 10(-3)), and concentrations of C-reactive protein decreased by 0.03 SD (-0.04 to -0.02; -3.4%; p=7.7 x 10(-14)). We noted the effects of the genetic score on these inflammation biomarkers to be directionally concordant with those of anakinra. The allele count of the genetic score had roughly log-linear, dose-dependent associations with both IL-1Ra concentration and risk of coronary heart disease. For people who carried four IL-1Ra-raising alleles, the odds ratio for coronary heart disease was 1.15 (1.08-1.22; p=1.8 x 10(-6)) compared with people who carried no IL-1Ra-raising alleles; the per-allele odds ratio for coronary heart disease was 1.03 (1.02-1.04; p=3.9 x 10(-10)). Perallele odds ratios were 0.97 (0.95-0.99; p=9.9 x 10(-4)) for rheumatoid arthritis, 0.99 (0.97-1.01; p=0.47) for type 2 diabetes, 1.00 (0.98-1.02; p=0.92) for ischaemic stroke, and 1.08 (1.04-1.12; p=1.8 x 10(-5)) for abdominal aortic aneurysm. In exploratory analyses, we observed per-allele increases in concentrations of proatherogenic lipids, including LDL-cholesterol, but no clear evidence of association for blood pressure, glycaemic traits, or any of the 24 other disorders studied. Modelling suggested that the observed increase in LDL-cholesterol could account for about a third of the association observed between the genetic score and increased coronary risk. Interpretation Human genetic data suggest that long-term dual IL-1 alpha/beta inhibition could increase cardiovascular risk and, conversely, reduce the risk of development of rheumatoid arthritis. The cardiovascular risk might, in part, be mediated through an increase in proatherogenic lipid concentrations. Copyright (C) The Interleukin 1 Genetics Consortium. Open Access article distributed under the terms of CC-BY-NC-ND.
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| 23. |
- Gaulton, Kyle J, et al.
(författare)
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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
- 2015
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:12, s. 1415-1415
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Tidskriftsartikel (refereegranskat)abstract
- We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
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| 24. |
- Geng, Xiumei, et al.
(författare)
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Bioinspired Ultrastable Lignin Cathode via Graphene Reconfiguration for Energy Storage
- 2017
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Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society (ACS). - 2168-0485. ; 5:4, s. 3553-3561
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Tidskriftsartikel (refereegranskat)abstract
- Lignin extracted from trees is one of the most abundant biopolymers on Earth. Quinone, a sub-structure in lignin, can be used for energy storage via reversible redox reactions through absorbing and releasing electrons and protons. However, these efforts have encountered hindrances, such as short life cycle, low cycling efficiency, and a high self-discharge rate. All of these issues are related to electrode dissolution by electrolyte solvents and the insulating nature of lignin. Addressing these critical challenges, for the first time we use a reconfigurable and hierarchical graphene cage to capture the lignin by mimicking the prey-trapping of venus flytraps. The reconfigurable graphene confines the lignin within the electrode to prevent its dissolution, while acting as a three-dimensional current collector to provide efficient electron transport pathways during the electrochemical reactions. This bioinspired design enables the best cycling performance of lignin reported so far at 88% capacitance retention for 15000 cycles and 211 F g-1 capacitance at a current density of 1.0 A g-1. This study demonstrates a feasible and effective strategy for solving the long-term cycling difficulties of lignin-based electrochemically active species, and makes it possible to utilize lignin as an efficient, cheap, and renewable energy storage material.
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| 25. |
- Haslam, Danielle E., et al.
(författare)
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Changes in metabolites during an oral glucose tolerance test in early and mid-pregnancy : Findings from the PEARLS randomized, controlled lifestyle trial
- 2020
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Ingår i: Metabolites. - : MDPI AG. - 2218-1989. ; 10:7
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Tidskriftsartikel (refereegranskat)abstract
- The oral glucose tolerance test (OGTT) is used to diagnose gestational and other types of diabetes. We examined metabolite changes during an OGTT, and how a comprehensive diet and physical activity intervention may influence these changes in a population of overweight/obese Hispanic pregnant women. Integration of changes in metabolites during an OGTT may help us gain preliminary insights into how glucose metabolism changes during pregnancy. Among women from the Pregnancy and EARly Lifestyle improvement Study (PEARLS), we measured metabolites during a multipoint OGTT (fasting, 30, 60 and 120 min) at early and mid-pregnancy. Metabolite levels were measured by liquid chromatography–mass spectrometry in plasma samples in the lifestyle intervention (n = 13) and control (n = 16) arms of the study. A total of 65 candidate metabolites were selected that displayed changes during an OGTT in previous studies. Paired and unpaired t-tests were used to examine differences in ∆fast-120 min: (1) at early and mid-pregnancy; and (2) by intervention assignment. We applied principal component analysis (PCA) to identify those metabolites that differed by intervention assignment and OGTT time points. Most of the characteristic changes in metabolites post-OGTT were similar at both gestational time points. PCA identified characteristic metabolite patterns associated with OGTT time points at both early and mid-pregnancy. These metabolites included ketone bodies, tryptophan, acyl carnitines, polyunsaturated fatty acids, and biomarkers related to bile acid, urea cycle, arginine, and proline metabolism. PCA identified distinct ∆fast-120 min in fatty acid, acyl carnitine, bile acid, ketone body, and amino acid levels at mid-compared to early pregnancy. Participants in the intervention group did not display mean decreases in ∆fast-120 min of several long-chain acyl carnitines that were observed in the control group. These findings provide preliminary insight into metabolites, whose role in increased insulin resistance during pregnancy, should be explored further in future studies.
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| 26. |
- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 27. |
- Henriksson, Gunnar, et al.
(författare)
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Is cellobiose dehydrogenase from Phanerochaete chrysosporium a lignin degrading enzyme?
- 2000
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Ingår i: Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. - 0167-4838 .- 1879-2588. ; 1480:02-jan, s. 83-91
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Tidskriftsartikel (refereegranskat)abstract
- Cellobiose dehydrogenase (CDH) is an extracellular redox enzyme of ping-pong type, i.e. it has separate oxidative and reductive half reactions. Several wood degrading fungi produce CDH, but the biological function of the enzyme is not known with certainty. It can, however, indirectly generate hydroxyl radicals by reducing Fe3+ to Fe2+ and O-2 to H2O2. Hydroxyl radicals are then generated by a Fenton type reaction and they can react with various wood compounds, including lignin. In this work we study the effect of CDH on a non-phenolic lignin model compound (3,4-dimethoxyphenyl glycol). The results indicate that CDH can affect lignins in three important ways. (1) It breaks beta-ethers; (2) it demethoxylates aromatic structures in lignins; (3) it introduces hydroxyl groups in non-phenolic lignins. The gamma-irradiated model compound gave a similar pattern of products as the CDH treated model compound? when the samples were analyzed by HPLC, suggesting that hydroxyl radicals are the active component of the CDH system.
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| 28. |
- Henriksson, Gunnar, 1965-, et al.
(författare)
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Lignin Utilization
- 2010
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Ingår i: Thermochemical conversion of biomass to liquid fuels and chemicals. - : RSC Publishing. - 9781849732260 ; , s. 222-262
-
Bokkapitel (refereegranskat)abstract
- Lignin is one of the most abundant biopolymers on Earth, carrying out important biological roles in vascular plants. It has somewhat higher energy content than polysaccharides, but has a complex and heterogeneous structure including covalent bonds to polysaccharides. The partly random structure of lignin is explained by the fact that it is created by an uncatalyzed radical polymerization. Lignin is obtained as a by-product of various types of technical processes based on biomass, of which chemical pulping of wood is the most important. These technical lignins have structures that differ from native lignin. Sulphite pulping of wood generates a water soluble lignin derivate, which among other things, is used as a dispersing agent and dust binder. Kraft pulping generates a lignin that is insoluble at neutral pH, which today is mainly burned for heat generation in the chemical recovery system of the kraft pulp mill. Recently, efficient methods have been developed for the preparation of lignin from the process liquids, for use in energy generation or other applications. Conversion of technical lignin to liquid fuels for use in combustion engines is an interesting possibility that represents a technical challenge. This chapter reviews the structure and biopolymerisation of lignin, reactions of lignin during technical processes, and different applications of technical lignins.
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| 29. |
- Huang, Kun, et al.
(författare)
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Enhanced peak growth of global vegetation and its key mechanisms
- 2018
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Ingår i: Nature Ecology and Evolution. - : Springer Science and Business Media LLC. - 2397-334X. ; 2:12, s. 1897-1905
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Tidskriftsartikel (refereegranskat)abstract
- The annual peak growth of vegetation is critical in characterizing the capacity of terrestrial ecosystem productivity and shaping the seasonality of atmospheric CO2 concentrations. The recent greening of global lands suggests an increasing trend of terrestrial vegetation growth, but whether or not the peak growth has been globally enhanced still remains unclear. Here, we use two global datasets of gross primary productivity (GPP) and a satellite-derived Normalized Difference Vegetation Index (NDVI) to characterize recent changes in annual peak vegetation growth (that is, GPPmax and NDVImax). We demonstrate that the peak in the growth of global vegetation has been linearly increasing during the past three decades. About 65% of the NDVImax variation is evenly explained by expanding croplands (21%), rising CO2 (22%) and intensifying nitrogen deposition (22%). The contribution of expanding croplands to the peak growth trend is substantiated by measurements from eddy-flux towers, sun-induced chlorophyll fluorescence and a global database of plant traits, all of which demonstrate that croplands have a higher photosynthetic capacity than other vegetation types. The large contribution of CO2 is also supported by a meta-analysis of 466 manipulative experiments and 15 terrestrial biosphere models. Furthermore, we show that the contribution of GPPmax to the change in annual GPP is less in the tropics than in other regions. These multiple lines of evidence reveal an increasing trend in the peak growth of global vegetation. The findings highlight the important roles of agricultural intensification and atmospheric changes in reshaping the seasonality of global vegetation growth.
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| 30. |
- Huang, Liming, 1993, et al.
(författare)
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Improving the performance of alkali-activated slag mortar with electro/chemically treated carbon fiber textile
- 2023
-
Ingår i: Journal of Cleaner Production. - : Elsevier Ltd. - 0959-6526 .- 1879-1786. ; 418
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Tidskriftsartikel (refereegranskat)abstract
- Alkali-activated slag is a widely used low-carbon binder. Incorporation of textile can mitigate the brittle weakness of alkali-activated composites. The bonding between fibers and matrix is critical for the performance of textile reinforced mortar. This paper is focused on the effect of different treatment methods on the bonding properties of carbon fiber in alkali-activated slag. The interfacial shear strength of fiber bundles in matrix was determined by the pull-out test. The flexural strength of the reinforced mortar was evaluated by a repeated bending. A scanning electron microscopy test was performed to characterize the interfacial properties of the fiber bundles. The results show that the interfacial shear strength of carbon fibers in matrix is improved by the electroplating with calcium silica slurry (CSS), impregnation in different solutions, and plasma treatments. An electroplating in CSS has the best improvement in the bonding strength with an increase by 620%. The CSS treatment increases the maximum flexural strength of CFT reinforced mortar with 22.5% and 30% at 7 and 28 d respectively, and it significantly inhibits the crack growth under the cyclic loading. This effect becomes more significant after a longer curing age. The electroplating treatment eliminates the cracks in the interface of fiber yarns. Slag reacts with the plated portlandite to strengthen the bonding between mortar and fiber bundles, so it has a better inhibiting effect on the crack growth after a longer curing. © 2023 The Authors
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| 31. |
- Huang, Liming, 1993, et al.
(författare)
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Moisture and ion transport properties in blended pastes and their relation to the refined pore structure
- 2022
-
Ingår i: Cement and Concrete Research. - : Elsevier BV. - 0008-8846. ; 161:106949
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a study of the moisture transport properties in blended pastes measured by a new procedure and setup. The dependence of moisture transport coefficient on relative humidity (RH) is confirmed. The differences in the moisture dependency may be due to discrepancies in the critical RH for the percolation of liquid. Fly ash and slag increase the percentage of mesopores or “ink-bottle” pores with a mesoscale neck and they strongly reduce the pore connectivity in pastes. These effects cause the evident reduction in the moisture and chloride diffusivity. The additional replacement with limestone filler has little effect on the pore connectivity. The formation factor controls the moisture transport at the high RH interval, but the volume of small pores (middle capillary and mesopores) is the major determinant at a low RH interval. The relationship between water-binder ratio, pore structure and moisture transport or chloride migration coefficient is discussed.
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| 32. |
- Huang, Liming, 1993, et al.
(författare)
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New insights into the reaction of tricalcium silicate (C 3 S) with solutions to the end of the induction period
- 2022
-
Ingår i: Cement and Concrete Research. - : Elsevier BV. - 0008-8846. ; 152
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Tidskriftsartikel (refereegranskat)abstract
- Although dissolution theory is widely used, in certain circumstance, it seems to be unable to explain the hydration of C3S. In this article, more attention is paid to the nucleation of hydration products. We find that the precipitation of C-S-H is a nonclassical nucleation process. It starts with nucleation of primary particles and then grows by particle attachment. A sharp increase in the reaction rate after induction period may come from the accelerating growth rate of C-S-H instead of dissolution of etch pits. The duration of induction period relates to the size of primary floc. Potassium salts influence the primary globule floc size and mitigate the effect from Al. The pH impacts ion species in solution to affect the dissolution and precipitation. A hypothesis regarding the dissolution of C3S and nucleation of C-S-H within the near-surface region may narrow the gap between dissolution theory and protective layer theory.
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| 33. |
- Huang, Liming, 1993, et al.
(författare)
-
Non-destructive test system to monitor hydration and strength development of low CO2 concrete
- 2023
-
Ingår i: Construction and Building Materials. - 0950-0618. ; 408
-
Tidskriftsartikel (refereegranskat)abstract
- Application of supplementary cementitious materials for production of low CO2 concrete affects the reaction kinetics, which alters the setting time and strength development. The different early-age behavior is of concern for quality control of concrete. Non-destructive test is very useful for monitoring the quality of low CO2 binder systems. This paper presents a new technique to monitor the electrical conductivity and temperature at different depths of hydrating concrete. Indices from monitoring system (conductivity, maturity and formation factor) are compared with data from widely-used methods (ultrasonic pulse velocity, penetration resistance and isothermal calorimetry). Results show that indices from the system can replicate the hydration evolution, setting time and compressive strength of low CO2 concrete. Electrical conductivity of concrete is very sensitive to mineral reactions and it reflects the hydration kinetic consistent with evolution of heat release. Linear correlations are found for penetration resistance in relation to ultrasonic pulse velocity, formation factor and maturity, respectively. The effects of binder type and water-to-binder ratio on hardening are strongly dependent on temperature. The proposed approach enables to include all these factors in characterizing the hardening process of concrete onsite. It is shown that formation factor performs better than ultrasonic pulse velocity on indicating the setting process. Formation factor is also a good parameter for quantitative description of compressive strength development, which is independent of the binder types, mixture proportions and curing ages.
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| 34. |
- Huang, Liming, 1993, et al.
(författare)
-
Recycling of the end-of-life lightweight aggregate concrete (LWAC) with a novel approach
- 2020
-
Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526. ; 275
-
Tidskriftsartikel (refereegranskat)abstract
- This work proposed an environmental-friendly approach for high-grade recycling of the end-of-life LWAC. The mechanical performance of mortar with recycled powder (RP), mortar with recycled fine aggregate (RFA) and recycled lightweight aggregate concrete (RLWAC) were investigated. Microstructure of mortar and RLWAC was detected to identify the properties of interfacial transition zone (ITZ). RP can prolong the setting of reference cement and the 10% dosage is better than 2% in not only retarding effect but also strength development. An appropriate content of RFA is beneficial for compressive strength. Replacing standard sand with 10% RFA increases the compressive strength of mortar by approximately 10%. However, a high replacement content (40%) of RFA brings about a reduction of compressive strength. The amount of RFA below 20% will not increase the dry shrinkage of mortar. The compressive strength of RLWAC is reduced by 10% RLWA but it has a significant increase when the replacement content reaches 30%. In mortar with RFA, cracks initiate from the ITZ of new sand and new paste and few cracks generate from old paste and old sand. Four types of ITZ that have distinct features are observed between cement paste and LWA in RLWAC.
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| 35. |
- Jiang, Sheng, et al.
(författare)
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Constructing Chromium Multioxide Hole-Selective Heterojunction for High-Performance Perovskite Solar Cells
- 2022
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Ingår i: Advanced Science. - : Wiley. - 2198-3844. ; 9:30
-
Tidskriftsartikel (refereegranskat)abstract
- Perovskite solar cells (PSCs) suffer from significant nonradiative recombination at perovskite/charge transport layer heterojunction, seriously limiting their power conversion efficiencies. Herein, solution-processed chromium multioxide (CrOx) is judiciously selected to construct a MAPbI(3)/CrOx/Spiro-OMeTAD hole-selective heterojunction. It is demonstrated that the inserted CrOx not only effectively reduces defect sites via redox shuttle at perovskite contact, but also decreases valence band maximum (VBM)-HOMO offset between perovskite and Spiro-OMeTAD. This will diminish thermionic losses for collecting holes and thus promote charge transport across the heterojunction, suppressing both defect-assisted recombination and interface carrier recombination. As a result, a remarkable improvement of 21.21% efficiency with excellent device stability is achieved compared to 18.46% of the control device, which is among the highest efficiencies for polycrystalline MAPbI(3) based n-i-p planar PSCs reported to date. These findings of this work provide new insights into novel charge-selective heterojunctions for further enhancing efficiency and stability of PSCs.
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| 36. |
- Keyu, Guo, et al.
(författare)
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A Phase-Domain Model of Dual Three-Phase Segmented Powered Linear PMSM for Hardware-assisted Real-Time Simulation
- 2022
-
Ingår i: IEEE Transactions on Industry Applications. - 0093-9994 .- 1939-9367. ; 58:4, s. 4511-4521
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, a Hardware-assisted real-time simulation phase-domain (PD) model of a dual three-phase segmented powered linear permanent magnet synchronous machine (SP-LPMSM) used in electromagnetic launch is established. The model is able to consider the end-effect, saturation effect, coupling effect and open-phase fault conditions, which are specially occurs in the segmented structure in SP-LPMSM. The unbalanced inductances and saturation effect caused by the segmented structure are investigated and a simplified look-up table for inductances is introduced. Additionally, to accurately evaluate the coupling effect, the permanent magnet (PM) flux linkage is decoupled into the product of unit PM flux linkage and coupling coefficient. In order to avoid the numerical impulse caused by the derivative in the progress of calculating back-EMF, sigmoid function is adopted to express the coupling coefficient. Meanwhile, to make the PD-model compatible with the open-circuit fault conditions, incidence matrices and current constraint matrices are introduced to unify the PD-models with different winding connection types and open circuit faults into one general form. The PD-Model realized in Field-Programmable Gate Arrays (FPGA) based hardware is validated in comparison with finite element analysis results.
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| 37. |
- Kohse-Höinghaus, Katharina, et al.
(författare)
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Chemistry diagnostics for monitoring
- 2023
-
Ingår i: Combustion Chemistry and the Carbon Neutral Future : What will the Next 25 Years of Research Require? - What will the Next 25 Years of Research Require?. - 9780323992138 ; , s. 417-501
-
Bokkapitel (refereegranskat)abstract
- Chemically sensitive diagnostics are indispensable to unravel reactive processes in combustion and beyond, to understand their development in time and space and to monitor the reaction progress under the conditions of interest. A multitude of techniques is available that may provide species composition together with other process-controlling variables as a function of the reaction environment. Analytical tools have been developed that range from one-of-a-kind large-facility instrumentation to robust sensors for use in technical systems and in the field. In this chapter, needs and developments for the near and midterm future are addressed combining individual contributions from selected perspectives and intertwining thoughts and ideas from different fields and expertise. Major advances can be expected from combinations of instrumentation and digital processes, with beneficial uses for a multitude of processes in carbon-reduced and carbon-neutral environments.
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| 38. |
- Laisk, Triin, et al.
(författare)
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The genetic architecture of sporadic and multiple consecutive miscarriage.
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for multiple (≥3) consecutive miscarriage, and up to 359,469 female controls. We identify one genome-wide significant association (rs146350366, minor allele frequency (MAF) 1.2%, P=3.2 × 10-8, odds ratio (OR)=1.4) for sporadic miscarriage in our European ancestry meta-analysis and three genome-wide significant associations for multiple consecutive miscarriage (rs7859844, MAF=6.4%, P=1.3 × 10-8, OR=1.7; rs143445068, MAF=0.8%, P=5.2 × 10-9, OR=3.4; rs183453668, MAF=0.5%, P=2.8 × 10-8, OR=3.8). We further investigate the genetic architecture of miscarriage with biobank-scale Mendelian randomization, heritability, and genetic correlation analyses. Our results show that miscarriage etiopathogenesis is partly driven by genetic variation potentially related to placental biology, and illustrate the utility of large-scale biobank data for understanding this pregnancy complication.
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| 39. |
- Lensink, Marc F., et al.
(författare)
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15-CAPRI experiment
- 2023
-
Ingår i: Proteins. - : WILEY. - 0887-3585 .- 1097-0134.
-
Tidskriftsartikel (refereegranskat)abstract
- We present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody-antigen complexes, and 7 large assemblies. On average similar to 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups and by 15 CAPRI scorer groups were evaluated using the CAPRI model quality measures and the DockQ score consolidating these measures. The prediction performance was quantified by a weighted score based on the number of models of acceptable quality or higher submitted by each group among their five best models. Results show substantial progress achieved across a significant fraction of the 60+ participating groups. High-quality models were produced for about 40% of the targets compared to 8% two years earlier. This remarkable improvement is due to the wide use of the AlphaFold2 and AlphaFold2-Multimer software and the confidence metrics they provide. Notably, expanded sampling of candidate solutions by manipulating these deep learning inference engines, enriching multiple sequence alignments, or integration of advanced modeling tools, enabled top performing groups to exceed the performance of a standard AlphaFold2-Multimer version used as a yard stick. This notwithstanding, performance remained poor for complexes with antibodies and nanobodies, where evolutionary relationships between the binding partners are lacking, and for complexes featuring conformational flexibility, clearly indicating that the prediction of protein complexes remains a challenging problem.
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| 40. |
- Li, Danqin, et al.
(författare)
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Enhanced and Balanced Charge Transport Boosting Ternary Solar Cells Over 17% Efficiency
- 2020
-
Ingår i: Advanced Materials. - : WILEY-V C H VERLAG GMBH. - 0935-9648 .- 1521-4095. ; 32:34
-
Tidskriftsartikel (refereegranskat)abstract
- Ternary architecture is one of the most effective strategies to boost the power conversion efficiency (PCE) of organic solar cells (OSCs). Here, an OSC with a ternary architecture featuring a highly crystalline molecular donor DRTB-T-C4 as a third component to the host binary system consisting of a polymer donor PM6 and a nonfullerene acceptor Y6 is reported. The third component is used to achieve enhanced and balanced charge transport, contributing to an improved fill factor (FF) of 0.813 and yielding an impressive PCE of 17.13%. The heterojunctions are designed using so-called pinning energies to promote exciton separation and reduce recombination loss. In addition, the preferential location of DRTB-T-C4 at the interface between PM6 and Y6 plays an important role in optimizing the morphology of the active layer.
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| 41. |
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| 42. |
- Li, Kefei, et al.
(författare)
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RILEM recommendation from TC 289-DCM: guideline for designing and operating long-term marine exposure sites
- 2024
-
Ingår i: Materials and Structures/Materiaux et Constructions. - 1359-5997. ; 57:3
-
Tidskriftsartikel (refereegranskat)abstract
- This guideline prescribes the technical requirements for the design and operation of long-term exposure sites in marine environments. The technical content includes the design of exposure site, the monitoring of environmental conditions, the monitoring of exposed specimens, the data management and the maintenance of exposure facilities. The design of exposure site covers the choice of exposure sites, the exposure infrastructure and facilities, exposure specimens and their placing and protection. Then, the guideline defines the environmental factors to be monitored and the corresponding monitoring methods. For the exposed specimens, the guideline specifies the target performance to monitor, the sampling, the testing and the reporting of exposure results. The data management deals with such aspects as the data storage, data transmission and the data sharing. At the end, the guideline gives the principles for the maintenance of the exposure facilities. This guideline summarizes the best practice of long-term exposure in marine environments, and it is expected to support the normalization of exposure practice and to generate more added values from this practice.
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| 43. |
- Li, X. F., et al.
(författare)
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A Centiparsec-scale Compact Radio Core in the Nearby Galaxy M60
- 2024
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 960:1
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Tidskriftsartikel (refereegranskat)abstract
- M60, an elliptical galaxy located 16.5 Mpc away, has an active nucleus with a very low luminosity and an extremely low accretion rate. Its central supermassive black hole (SMBH) has a mass of M BH ∼ 4.5 × 109 M ⊙ and a Schwarzschild radius corresponding to R S ∼ 5.4 μas. To investigate the nature of its innermost radio nucleus, data from the Very Long Baseline Array (VLBA) at 4.4 and 7.6 GHz were reduced. The VLBA images reveal a compact component with total flux densities of ∼20 mJy at both frequencies, a size of ≤0.27 mas (99.7% confidence level), about 0.022 pc (50 R S) at 7.6 GHz, and a brightness temperature of ≥6 × 109 K. This suggests that the observed centiparsec-scale compact core could be attributed to a nonthermal jet base or an advection-dominated accretion flow (ADAF) with nonthermal electrons. The extremely compact structure also supports the presence of an SMBH in the center. Our results indicate that M60 is a promising target for broadband very long baseline interferometry observations at millimeter wavelengths to probe ADAF scenarios and tightly constrain the potential photon ring (about 28 μas) around its SMBH.
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| 44. |
- Li, Yongqiang, et al.
(författare)
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Activation of locally excavated spoil for utilization in limestone calcined clay cement (LC3)
- 2024
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Ingår i: Construction and Building Materials. - 0950-0618. ; 420
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Tidskriftsartikel (refereegranskat)abstract
- The utilization of clay to produce limestone calcined clay cement (LC3) is limited in China due to environmental concerns related to clay excavation. This study explores the potential to activate the fine-grained clay sourced from excavated spoil in Shenzhen, China for LC3 production. A water washing method was introduced to treat the excavated spoil, enriching the clays’ kaolinite content in a range of 72.4–83.1%. Incorporation of calcined clay with different calcination procedures will modify the hydration rate for aluminate, and the longer calcination after 2 h is detrimental for clay reactivity. Additionally, using excavated spoil calcined at 800 °C with more than 2 h in paste yields compressive strength comparable to that of paste made of ordinary Portland cement (OPC). Calcining at 800 °C for 2 h is the optimal calcination procedure to activate the collected soil. Notably, this activation approach for LC3 production exhibits remarkable environmental and economic benefits, reinforcing the potential for extensive adoption of LC3 within China.
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| 45. |
- Li, Zhao, et al.
(författare)
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Non-uniform seasonal warming regulates vegetation greening and atmospheric CO2 amplification over northern lands
- 2018
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 13:12
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Tidskriftsartikel (refereegranskat)abstract
- The enhanced vegetation growth by climate warming plays a pivotal role in amplifying the seasonal cycle of atmospheric CO2 at northern lands (>50° N) since 1960s. However, the correlation between vegetation growth, temperature and seasonal amplitude of atmospheric CO2 concentration have become elusive with the slowed increasing trend of vegetation growth and weakened temperature control on CO2 uptake since late 1990s. Here, based on in situ atmospheric CO2 concentration records from the Barrow observatory site, we found a slowdown in the increasing trend of the atmospheric CO2 amplitude from 1990s to mid-2000s. This phenomenon was associated with the paused decrease in the minimum CO2 concentration ([CO2]min), which was significantly correlated with the slowdown of vegetation greening and growing-season length extension. We then showed that both the vegetation greenness and growing-season length were positively correlated with spring but not autumn temperature over the northern lands. Furthermore, such asymmetric dependences of vegetation growth upon spring and autumn temperature cannot be captured by the state-of-art terrestrial biosphere models. These findings indicate that the responses of vegetation growth to spring and autumn warming are asymmetric, and highlight the need of improving autumn phenology in the models for predicting seasonal cycle of atmospheric CO2 concentration.
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| 46. |
- Li, Zhen, et al.
(författare)
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Using alumina-rich sludge and phosphogypsum manufactures low-CO 2 cement
- 2021
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Ingår i: Construction and Building Materials. - : Elsevier BV. - 0950-0618. ; 288
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Tidskriftsartikel (refereegranskat)abstract
- Calcium sulfoaluminate-belite (CŜAB) cement has been proposed as a low-CO cement for substituting ordinary Portland cement (OPC). The aim of this work was to study synthesis of CŜAB cement from two industrial wastes, namely Alumina-rich sludge (AS) and phosphogypsum (PG). The main phases of the synthesized cement were ye'elimite, larnite, ternesite and anhydrite. The properties of CŜAB cement were investigated through the test of compressive strength, setting time and hydration products. We found that the optimal procedure was burning at 1150 °C for 1 h which needs much lower energy than traditional production. CŜAB cement could reach 39.4 MPa at 28 d hydration, when basicity factor, the ratio of aluminum to sulfur and aluminum to silicon ratio were 0.8, 2.5 and 3 respectively. Blending phosphogypsum into clinker, made paste get a much higher compressive strength (53.2 MPa at 28 d). Adding phosphogypsum to CŜAB cement hindered hydration process of cement and decreased hydration products except for ettringite. Production of this cement is beneficial to recycle industrial wastes and reduce CO emission. This is meaningful for further development of cement industry. 2 2
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| 47. |
- Lin, Yujia, et al.
(författare)
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Human digital twin : a survey
- 2024
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Ingår i: Journal of Cloud Computing. - : Springer. - 2192-113X. ; 13:1
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Forskningsöversikt (refereegranskat)abstract
- The concept of the Human Digital Twin (HDT) has recently emerged as a new research area within the domain of digital twin technology. HDT refers to the replica of a physical-world human in the digital world. Currently, research on HDT is still in its early stages, with a lack of comprehensive and in-depth analysis from the perspectives of universal frameworks, core technologies, and applications. Therefore, this paper conducts an extensive literature review on HDT research, analyzing the underlying technologies and establishing typical frameworks in which the core HDT functions or components are organized. Based on the findings from the aforementioned work, the paper proposes a generic architecture for the HDT system and describes the core function blocks and corresponding technologies. Subsequently, the paper presents the state of the art of HDT technologies and their applications in the healthcare, industry, and daily life domains. Finally, the paper discusses various issues related to the development of HDT and points out the trends and challenges of future HDT research and development.
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| 48. |
- Liu, Can, et al.
(författare)
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A Review of the Distribution of Antibiotics in Water in Different Regions of China and Current Antibiotic Degradation Pathways
- 2021
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Ingår i: Frontiers in Environmental Science. - : Frontiers Media SA. - 2296-665X. ; 9
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Forskningsöversikt (refereegranskat)abstract
- Antibiotic pollution is becoming an increasingly serious threat in different regions of China. The distribution of antibiotics in water sources varies significantly in time and space, corresponding to the amount of antibiotics used locally. The main source of this contamination in the aquatic environment is wastewater from antibiotic manufacturers, large scale animal farming, and hospitals. In response to the excessive antibiotic contamination in the water environment globally, environmentally friendly alternatives to antibiotics are being developed to reduce their use. Furthermore, researchers have developed various antibiotic treatment techniques for the degradation of antibiotics, such as physical adsorption, chemical oxidation, photodegradation, and biodegradation. Among them, biodegradation is receiving increasing attention because of its low cost, ease of operation, and lack of secondary pollution. Antibiotic degradation by enzymes could become the key strategy of management of antibiotics pollution in the environment in future. This review summarizes research on the distribution of antibiotics in China's aquatic environments and different techniques for the degradation of antibiotics. Special attention is paid to their degradation by various enzymes. The adverse effects of the pollutants and need for more effective monitoring and mitigating pollution are also highlighted.
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| 49. |
- Liu, Can, et al.
(författare)
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Immobilized Crosslinked Pectinase Preparation on Porous ZSM-5 Zeolites as Reusable Biocatalysts for Ultra-Efficient Hydrolysis of beta-Glycosidic Bonds
- 2021
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Ingår i: Frontiers in Chemistry. - : Frontiers Media SA. - 2296-2646. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we immobilized pectinase preparation on porous zeolite ZSM-5 as an enzyme carrier. We realized this immobilized enzyme catalyst, pectinase preparation@ZSM-5, via a simple combined strategy involving the van der Waals adsorption of pectinase preparation followed by crosslinking of the adsorbed pectinase preparation with glutaraldehyde over ZSM-5. Conformal pectinase preparation coverage of various ZSM-5 supports was achieved for the as-prepared pectinase preparation@ZSM-5. The porous pectinase preparation@ZSM-5 catalyst exhibited ultra-efficient biocatalytic activity for hydrolyzing the beta-glycosidic bonds in the model substrate 4-nitrophenyl beta-D-glucopyranoside, with a broad operating temperature range, high thermal stability, and excellent reusability. The relative activity of pectinase preparation@ZSM-5 at a high temperature (70 degrees C) was nine times higher than that of free pectinase preparation. Using thermal inactivation kinetic analysis based on the Arrhenius law, pectinase preparation@ZSM-5 showed higher activation energy for denaturation (315 kJ mol(-1)) and a longer half-life (62 min(-1)) than free pectinase preparation. Moreover, a Michaelis-Menten enzyme kinetic analysis indicated a higher maximal reaction velocity for pectinase preparation@ZSM-5 (0.22 mu mol mg(-1) min(-1)). This enhanced reactivity was attributed to the microstructure of the immobilized pectinase preparation@ZSM-5, which offered a heterogeneous reaction system that decreased the substrate-pectinase preparation binding affinity and modulated the kinetic characteristics of the enzyme. Additionally, pectinase preparation@ZSM-5 showed the best ethanol tolerance among all the reported pectinase preparation-immobilized catalysts, and an activity 247% higher than that of free pectinase preparation at a 10% (v/v) ethanol concentration was measured. Furthermore, pectinase preparation@ZSM-5 exhibited potential for practical engineering applications, promoting the hydrolysis of beta-glycosidic bonds in baicalin to convert it into baicalein. This was achieved with a 98% conversion rate, i.e., 320% higher than that of the free enzyme.
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| 50. |
- Lu, Qinghua, et al.
(författare)
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CF4BDA: A Conceptual Framework for Big Data Analytics Applications in the Cloud
- 2015
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Ingår i: IEEE Access. - 2169-3536. ; 3, s. 1944-1952
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Tidskriftsartikel (refereegranskat)abstract
- Building big data analytics applications (BDA) in the Cloud introduces inevitable challenges such as loss of control and uncertainty. To address the existing challenges, numerous efforts have been made on BDA application engineering to optimise quality of BDA applications in the Cloud, such as performance and reliability. However, there is still a lack of systematic view on engineering BDA applications in the Cloud. Therefore, in this paper, we present a conceptual framework named CF4BDA to analyse existing work on BDA applications from two perspectives: the lifecycle of BDA applications and the objects involved in the context of BDA applications in the Cloud. The framework can help researchers and practitioners identify the research opportunities in a structured way and guide implementing BDA applications in the Cloud. We perform a preliminary evaluation of the usefulness of CF4BDA by applying it to analyse a set of representative studies.
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