| 1. |
- Kristan, Matej, et al.
(författare)
-
The Ninth Visual Object Tracking VOT2021 Challenge Results
- 2021
-
Ingår i: 2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021). - : IEEE COMPUTER SOC. - 9781665401913 ; , s. 2711-2738
-
Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2021 is the ninth annual tracker benchmarking activity organized by the VOT initiative. Results of 71 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in recent years. The VOT2021 challenge was composed of four sub-challenges focusing on different tracking domains: (i) VOT-ST2021 challenge focused on short-term tracking in RGB, (ii) VOT-RT2021 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2021 focused on long-term tracking, namely coping with target disappearance and reappearance and (iv) VOT-RGBD2021 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2021 dataset was refreshed, while VOT-RGBD2021 introduces a training dataset and sequestered dataset for winner identification. The source code for most of the trackers, the datasets, the evaluation kit and the results along with the source code for most trackers are publicly available at the challenge website(1).
|
|
| 2. |
- An, Junghwa, et al.
(författare)
-
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 October 2009-30 November 2009
- 2010
-
Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 10:2, s. 404-408
-
Tidskriftsartikel (refereegranskat)abstract
- This article documents the addition of 411 microsatellite marker loci and 15 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Acanthopagrus schlegeli, Anopheles lesteri, Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus oryzae, Aspergillus terreus, Branchiostoma japonicum, Branchiostoma belcheri, Colias behrii, Coryphopterus personatus, Cynogolssus semilaevis, Cynoglossus semilaevis, Dendrobium officinale, Dendrobium officinale, Dysoxylum malabaricum, Metrioptera roeselii, Myrmeciza exsul, Ochotona thibetana, Neosartorya fischeri, Nothofagus pumilio, Onychodactylus fischeri, Phoenicopterus roseus, Salvia officinalis L., Scylla paramamosain, Silene latifo, Sula sula, and Vulpes vulpes. These loci were cross-tested on the following species: Aspergillus giganteus, Colias pelidne, Colias interior, Colias meadii, Colias eurytheme, Coryphopterus lipernes, Coryphopterus glaucofrenum, Coryphopterus eidolon, Gnatholepis thompsoni, Elacatinus evelynae, Dendrobium loddigesii Dendrobium devonianum, Dysoxylum binectariferum, Nothofagus antarctica, Nothofagus dombeyii, Nothofagus nervosa, Nothofagus obliqua, Sula nebouxii, and Sula variegata. This article also documents the addition of 39 sequencing primer pairs and 15 allele specific primers or probes for Paralithodes camtschaticus.
|
|
| 3. |
- Wu, Jianmin, et al.
(författare)
-
MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4
- 2020
-
Ingår i: Journal of Investigative Dermatology. - : Elsevier. - 0022-202X .- 1523-1747. ; 140:2, s. 465-476
-
Tidskriftsartikel (refereegranskat)abstract
- Venous ulcers are the most common type of human chronic nonhealing wounds and are stalled in a constant and excessive inflammatory state. The molecular mechanisms underlying the chronic wound inflammation remain elusive. Moreover, little is known about the role of regulatory RNAs, such as microRNAs, in the pathogenesis of venous ulcers. We found that both microRNA (miR)-34a and miR-34c were upregulated in the wound-edge epidermal keratinocytes of venous ulcers compared with normal wounds or the skin. In keratinocytes, miR-34a and miR-34c promoted inflammatory chemokine and cytokine production. In wounds of wild-type mice, miR-34a-mimic treatment enhanced inflammation and delayed healing. To further explore how miR-34 functions, LGR4 was identified as a direct target mediating the proinflammatory function of miR-34a and miR-34c. Interestingly, impaired wound closure with enhanced inflammation was also observed in Lgr4 knockout mice. Mechanistically, the miR-34-LGR4 axis regulated GSK-3β-induced p65 serine 468 phosphorylation, changing the activity of the NF-κB signaling pathway. Collectively, the miR-34-LGR4 axis was shown to regulate keratinocyte inflammatory response, the deregulation of which may play a pathological role in venous ulcers.
|
|
| 4. |
- Yang, Geng, et al.
(författare)
-
A Health-IoT Platform Based on the Integration of Intelligent Packaging, Unobtrusive Bio-Sensor, and Intelligent Medicine Box
- 2014
-
Ingår i: IEEE Transactions on Industrial Informatics. - : IEEE. - 1551-3203 .- 1941-0050. ; 10:4, s. 2180-2191
-
Tidskriftsartikel (refereegranskat)abstract
- In-home healthcare services based on the Internet-of-Things (IoT) have great business potential; however, a comprehensive platform is still missing. In this paper, an intelligent home-based platform, the iHome Health-IoT, is proposed and implemented. In particular, the platform involves an open-platform-based intelligent medicine box (iMedBox) with enhanced connectivity and interchangeability for the integration of devices and services; intelligent pharmaceutical packaging (iMedPack) with communication capability enabled by passive radio-frequency identification (RFID) and actuation capability enabled by functional materials; and a flexible and wearable bio-medical sensor device (Bio-Patch) enabled by the state-of-the-art inkjet printing technology and system-on-chip. The proposed platform seamlessly fuses IoT devices (e. g., wearable sensors and intelligent medicine packages) with in-home healthcare services (e. g., telemedicine) for an improved user experience and service efficiency. The feasibility of the implemented iHome Health-IoT platform has been proven in field trials.
|
|
| 5. |
- Daneshjou, Roxana, et al.
(författare)
-
Working toward precision medicine : Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges
- 2017
-
Ingår i: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; 38:9, s. 1182-1192
-
Tidskriftsartikel (refereegranskat)abstract
- Precision medicine aims to predict a patient's disease risk and best therapeutic options by using that individual's genetic sequencing data. The Critical Assessment of Genome Interpretation (CAGI) is a community experiment consisting of genotype-phenotype prediction challenges; participants build models, undergo assessment, and share key findings. For CAGI 4, three challenges involved using exome-sequencing data: Crohn's disease, bipolar disorder, and warfarin dosing. Previous CAGI challenges included prior versions of the Crohn's disease challenge. Here, we discuss the range of techniques used for phenotype prediction as well as the methods used for assessing predictive models. Additionally, we outline some of the difficulties associated with making predictions and evaluating them. The lessons learned from the exome challenges can be applied to both research and clinical efforts to improve phenotype prediction from genotype. In addition, these challenges serve as a vehicle for sharing clinical and research exome data in a secure manner with scientists who have a broad range of expertise, contributing to a collaborative effort to advance our understanding of genotype-phenotype relationships.
|
|
| 6. |
- Machiela, Mitchell J., et al.
(författare)
-
Characterization of Large Structural Genetic Mosaicism in Human Autosomes
- 2015
-
Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 96:3, s. 487-497
-
Tidskriftsartikel (refereegranskat)abstract
- Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 x 3 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.
|
|
| 7. |
- Wang, Xiaolin, et al.
(författare)
-
Comprehension of the Effect of a Hydroxyl Group in Ancillary Ligand on Phosphorescent Property for Heteroleptic Ir(III) Complexes : A Computational Study Using Quantitative Prediction
- 2017
-
Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 56:15, s. 8986-8995
-
Tidskriftsartikel (refereegranskat)abstract
- A new Ir(III) complex (dfpypya)(2)Ir(pic-OH) (2) is theoretically designed by introduction of a simple hydroxyl group into the ancillary ligand on the basis of (dfpypya)(2)Ir(pic) (1) with the aim to get the high efficiency and stable blue-emitting phosphors, where dfpypya is 3-methyl-6-(2',4'-difluoro-pyridinato)pyridazine, pic is picolinate, and pic OH is 3-hydroxypicolinic acid. The other configuration (dfpypya)(2)Ir(pic OH)' (3) is also investigated to compare with 2. The difference between 2 and 3 is whether the intramolecular hydrogen bond is formed in the (dfpypya)(2)Ir(pic OH). The quantum yield is determined by three different methods including the semiquantitative and quantitative methods. To quantitatively determine the quantum yield is still not an easy task to be completed. This work would provide some useful advices to select the suitable method to reliably evaluate the quantum yield. Complex 2 has larger quantum yield and more stability as compared with 1 and 3. The formation of intramolecular hydrogen bond would become a new method to design new phosphor with the desired properties.
|
|
| 8. |
- Carlsson, Niklas, et al.
(författare)
-
Guest Editorial - Cloud and Big Data
- 2014
-
Ingår i: Journal of Communications. - : Engineering and Technology Publishing. - 1796-2021 .- 2374-4367. ; 9:4, s. i-iii
-
Tidskriftsartikel (refereegranskat)abstract
- In the current digital age, massive amounts of data are generated in many different ways and forms. The data may be collected from everything from personal web logs to purposefully placed sensors. Today, companies and researchers use this data for everything from targeted personalized ads based on social data to solving important scientific problems that may help future generations of word citizens. Regardless if measured in monetary profit or other measures, the value of this data has proven valuable for many purposes and has led us into the Big Data era. Due to the large volume of data, Big Data requires significant storage, processing, and bandwidth resources. To date, the Cloud provides the largest collection of disk storage, CPU power, and network bandwidth, which makes it a natural choice for housing the Big Data.
|
|
| 9. |
- He, Peng, et al.
(författare)
-
127I and 129I species in the English Channel and its adjacent areas : uncovering impact on the isotopes marine pathways
- 2022
-
Ingår i: Water Research. - : Elsevier. - 0043-1354 .- 1879-2448. ; 225
-
Tidskriftsartikel (refereegranskat)abstract
- Radioactive iodine-129 has been released from the La Hague nuclear fuel reprocessing facility (NRF) into the English Channel, but the distribution and transformation of the isotope species, and environmental consequences have not been fully characterized in the Channel. Here we present data on iodine isotopes (129I and 127I) species in surface water of the English Channel and the southern Celtic Sea. Compared to 127I species, the concentrations of 129I- and 129IO3-show more variations, but iodate is the major species for both 129I and 127I. Our data provide new information regarding iodide-iodate inter-conversion showing that water dilution and mixing are the main factors affecting the 127I and 129I species distribution in the Channel. Some reduction of iodate occurs within the English Channel and mainly in the west part because of biotic processes. The 129I species transformation is overall insignificant, especially in the eastern Channel, where a constant value of 129IO3- /129I is observed, which might characterize the La Hague wastewater signal. In the Celtic Sea, oxidation of iodide can be traced by 127I and 129I species. On a larger scale,129I generally experienced an oxidation process in the Atlantic Ocean, while in the coast of shallow shelf seas, new produced 129I- can be identified, especially in the German Bight and the Baltic Sea. The data of 129I species in the English Channel can provide estimate of redox rates in a much broader marine areas if the transit time of 129I from La Hague is well-defined. Furthermore, estimate of inventories for 129I and its species in the Channel, and fluxes of 129I species from the English Channel to the North Sea add important information to the geochemical cycle of 129I.
|
|
| 10. |
- Li, H., et al.
(författare)
-
Field-scale assessment of direct and indirect effects of soil texture on organic matter mineralization during a dry summer
- 2023
-
Ingår i: Science of the Total Environment. - : Elsevier B.V.. - 0048-9697 .- 1879-1026. ; 899
-
Tidskriftsartikel (refereegranskat)abstract
- Soil texture plays a crucial role in organic matter (OM) mineralization through both direct interactions with minerals and indirect effects on soil moisture. Separating these effects could enhance the modelling of soil organic carbon (SOC) dynamics under climate change scenarios. However, the attempts have been limited small-scale experiments. Here, we studied the effects of soil texture on added OM mineralization in loamy sand, loam and silt loam soils in nine agricultural fields in Flanders, Belgium. Soil moisture, temperature, groundwater table depth and the mineralization of 13C-labeled ryegrass were monitored in buried mesocosms for approximately three months during a dry summer. Ryegrass-C mineralization was lowest in the loamy sand (39 ± 7 %) followed by silt loam (48 ± 7 %) and loam (63 ± 5 %) soils, challenging the current clay%-based moderation of C-mineralization rates in soil models. Soil temperature was not influenced by soil texture, whereas soil moisture was indeed dependent on soil texture. It appears that capillarity sustained upward water supply from groundwater to the topsoil in loam and silt loam soils but not in loamy sand soil, although this difference in capillary rise could not fully explain the higher moisture content in loam than that in silt loam soils. Additionally, soil texture only impacted remnant added ryegrass pieces (>500 μm) but not the finer ryegrass-derived SOC (<500 μm), which might point at the important indirect control of texture on OM mineralization during prolonged summer drought. However, these effects are only manifested during drought when no other factors (e.g., groundwater depth or subsurface water flows) exert an overriding impact on the soil water balance. Overall, our findings highlight the need to properly incorporate the indirect effects of soil texture on OM mineralization into soil carbon models to accurately predict soil C stocks under future climate change scenarios.
|
|
| 11. |
- Li, Jun, et al.
(författare)
-
Trust based service selection in service oriented environment
- 2012
-
Ingår i: International Journal of Web Services Research. - : IGI Global. - 1545-7362 .- 1546-5004. ; 9:3, s. 23-42
-
Tidskriftsartikel (refereegranskat)abstract
- In a service-oriented environment, it is inevitable and indeed quite common to deal with web services, whose reliability is unknown to the users. The reputation system is a popular technique currently used for providing a global quality score of a service provider to requesters. However, such global information is far from sufficient for service requesters to choose the most qualified services. In order to tackle this problem, the authors present a trust based architecture containing a computational trust model for quantifying and comparing the trustworthiness of services. In this trust model, they firstly construct a network based on the direct trust relations between participants and rating similarity in service oriented environments, then propose an algorithm for propagating trust in the social network based environment which can produce personalized trust information for a specific service requester, and finally implement the trust model and simulate various malicious behaviors in not only dense but also sparse networks which can verify the attack-resistant and robustness of the proposed approach. The experiment results also demonstrate the feasibility and benefit of the approach.
|
|
| 12. |
- Li, Lili, et al.
(författare)
-
UV-protection and fluorescence properties of the exoskeleton obtained from a living diatom modified by an Eu3+-complex
- 2021
-
Ingår i: Journal of Materials Chemistry C. - : ROYAL SOC CHEMISTRY. - 2050-7526 .- 2050-7534. ; 9:31, s. 10005-10012
-
Tidskriftsartikel (refereegranskat)abstract
- In this article, a natural biological porous material, from living diatoms, is used to prepare new UV-protection hybrid materials with an Eu3+-complex. By removing the organic protoplasm of living diatoms, the exoskeleton with a regular pore structure arrangement was obtained. The Eu3+-complex was chemically bonded to the exoskeleton modified by the silane coupling agent (3-aminopropyl)trimethoxy silane (APTMS). Compared with pure Eu3+-complexes, the fluorescence intensity of this hybrid material was increased by approximately 10 times. For illustrating its applications in the field of UV-protection, we mixed the USDU with polyacrylonitrile to produce flexible and transparent polymer films. The hybrid composite film (USDU@PAN) achieved partial absorption of ultraviolet light between 200 and 400 nm. At the same time, it also emits visible fluorescence and the intensity of the fluorescence is greatly increased. Therefore, the USDU@PAN film has wide application prospects in areas such as photoelectric sensors and UV-protection devices. More importantly, we transform natural organisms into materials with excellent optical properties. Therefore, it can be used in the field of UV-protection.
|
|
| 13. |
- Machiela, Mitchell J, et al.
(författare)
-
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
- 2016
-
Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.
|
|
| 14. |
- Min, Liu, et al.
(författare)
-
Clinical efficacy of irinotecan plus raltitrexed chemotherapy in refractory esophageal squamous cell cancer
- 2020
-
Ingår i: Anti-Cancer Drugs. - : LIPPINCOTT WILLIAMS & WILKINS. - 0959-4973 .- 1473-5741. ; 31:4, s. 403-410
-
Tidskriftsartikel (refereegranskat)abstract
- Our retrospective study assessed the efficacy and safety of irinotecan plus raltitrexed in esophageal squamous cell cancer (ESCC) patients who were previously treated with multiple systemic therapies. Between January 2016 and December 2018, records of 38 ESCC patients who underwent irinotecan plus raltitrexed chemotherapy after at least one line of chemotherapy were reviewed. Efficacy assessment was performed every two cycles according to the RECIST version 1.1. A total of 95 cycles of chemotherapy were administered, and the median course was 3 (range 2-6). There was no treatment-related death. Nine patients had partial response, 21 had stable disease and eight had progressive disease. The overall objective response rate was 23.68% (9/38) and the disease control rate was78.94% (30/38). After a median follow-up of 18.5 months, the median progression-free survival and overall survival were 105 and 221 days, respectively. There were five patients (13.15%) with grade 3/4 leukopenia, three patients (7.89%) with grade 3/4 neutropenia and one patient (2.63%) with grade 3/4 diarrhea. The combination of irinotecan plus raltitrexed was effective for pretreated ESCC patients. Further studies are needed to determine the optimal dose of the two drugs.
|
|
| 15. |
- Nikitin, Anton, et al.
(författare)
-
Hydrogen storage in carbon nanotubes through the formation of stable C-H bonds
- 2008
-
Ingår i: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 8:1, s. 162-167
-
Tidskriftsartikel (refereegranskat)abstract
- To determine if carbon-based materials can be used for hydrogen storage, we have studied hydrogen chemisorption in single-walled carbon nanotubes. Using atomic hydrogen as the hydrogenation agent, we demonstrated that maximal degree of nanotube hydrogenation depends on the nanotube diameter, and for the diameter values around 2.0 nm nanotube-hydrogen complexes with close to 100% hydrogenation exist and are stable at room temperature. This means that specific carbon nanotubes can have a hydrogen storage capacity of more than 7 wt % through the formation of reversible C-H bonds.
|
|
| 16. |
- Shen, Zichao, et al.
(författare)
-
Analysis of Driving Behavior in Unprotected Left Turns for Autonomous Vehicles using Ensemble Deep Clustering
- 2023
-
Ingår i: IEEE Transactions on Intelligent Vehicles. - 2379-8858. ; In Press
-
Tidskriftsartikel (refereegranskat)abstract
- The advent of autonomous driving technology offers transformative potential in mitigating traffic congestion and enhancing road safety. A particularly challenging aspect of traffic dynamics is the unprotected left turn-a scenario at an intersection where the vehicle intending to turn left does not have a dedicated traffic signal, posing a risk to traffic safety and efficiency. This study investigates the dynamics of unprotected left turns by employing data-driven techniques that analyze multi-vehicle data and trajectory patterns to decode complex interactions and behaviors that occur during this maneuver. Our research targets the subtleties of driver behavior in these situations, employing a novel Ensemble Deep Clustering algorithm that innovatively categorizes driving behaviors based on a combination of learned representations and clustering advancements. The deep clustering component involves an iterative process that refines behavioral categorization, while the ensemble technique enhances the precision of these determinations. Using the INTERACTION Dataset, the proposed model is trained and evaluated to offer a better understanding of the intricate driving behaviors in unprotected left turns at intersections. Through the quantitative analysis and comparison with the baseline, we show the superiority of the algorithm, and the results are also interpretable. This methodology can be utilized to improve the decision-making of autonomous vehicles in such scenarios, thus improving the safety of autonomous vehicles, traffic efficiency, and realizing human-robot interaction between autonomous vehicles and drivers.
|
|
| 17. |
- Su, Ruoyu, et al.
(författare)
-
A Mobile Node Assisted Localization System for Wireless Sensor Networks
- 2021
-
Ingår i: IWCMC 2021: 2021 17TH INTERNATIONAL WIRELESS COMMUNICATIONS & MOBILE COMPUTING CONFERENCE (IWCMC). - 2376-6492. - 9781728186160 ; , s. 1716-1720
-
Konferensbidrag (refereegranskat)abstract
- Wireless sensor network (WSN), consisting of several sensor nodes, is one of the most promising technologies emerged in the past decade. The positioning system for WSN is particularly meaningful and widely used in the military surveillance, air-sea rescue, traffic monitoring, and etc. However, the traditional positioning system always suffers from deployment and maintenance of anchors. In this paper, we propose a positioning system employing a Raspberry Pi platform attached to a DJI drone as a mobile anchor. The DJI drone can serve as multiple virtual anchors by moving and broadcasting its location information periodically. Thus, it is possible to localize sensor node by itself when the sensor node collects the drone's position. A Gauss-Newton method is applied to improve the accuracy of the proposed positioning system. We also elaborate the adaption of the Gauss-Newton method with the geodetic coordinates. The goal of the proposed positioning system is to achieve higher accuracy and higher coverage at lower cost.
|
|
| 18. |
- Su, Ruoyu, et al.
(författare)
-
Analysis of Outage Probability for Millimeter Wave Communications
- 2021
-
Ingår i: IWCMC 2021: 2021 17TH INTERNATIONAL WIRELESS COMMUNICATIONS & MOBILE COMPUTING CONFERENCE (IWCMC). - 2376-6492. - 9781728186160 ; , s. 2194-2198
-
Konferensbidrag (refereegranskat)abstract
- As the data traffic in future wireless communications will explosively grow up to 1000-fold by the deployment of 5G, several technologies are emerging to satisfy this demand, including multiple-input multiple-output (MIMO), millimeter wave communications, Non-orthogonal Multiple Access (NOMA), etc. Millimeter wave communication is a promising solution since it can provide tens of GHz bandwidth by fundamentally exploring higher unoccupied spectrum resources. As the wavelength of higher frequency shrinks, it is possible to design more compact antenna array with large number of antennas with independent RF (Radio Frequency) chains, causing high cost and complexity. By exploring the spatial sparsity of the millimeter wave channels, lens antenna array has been investigated recently as a promising choice with limited RF chains and low complexity. In this paper, we investigate the outage probability for highway communication systems with lens antenna array, under overtaking scenario, where high mobility of users is expected. When a vehicle is trying to pass another one, the channels between these two vehicles and the RSU (Road Side Unit) are unresolvable, thus causing outage for at least tens of symbol durations. We apply power-domain NOMA in this scenario, where these two users are paired by a threshold derived with the QoS of each user, to alleviate this problem and achieve low outage probability.
|
|
| 19. |
- Wang, Xiaolin, et al.
(författare)
-
Elevated CO2 effects on Zn and Fe nutrition in vegetables: A meta-analysis
- 2024
-
Konferensbidrag (refereegranskat)abstract
- The atmospheric carbon dioxide (CO2) concentration has been progressively increasing since the onset of the Industrial Revolution and has already reached at around 420 μmol mol⁻¹ nowadays. It is well recognized that elevated CO2 concentration stimulates the yield for C3 crops, but it also simultaneously changes the essential nutrients. However, compared with the main crops, far less attention has been devoted to the effects of elevated CO2 concentration on vegetable growth and quality. Vegetables are highly recommended in daily diets due to their diverse range of beneficial compounds, such as vitamins, antioxidants, minerals, and dietary fiber. In controlled greenhouse vegetable cultivation, elevated CO2 has been widely adopted as an agricultural practice for enhancing plant growth. Thus, understanding both vegetable growth and nutrient status is crucial to assess the potential impacts of elevated CO2 on future food security in both natural and controlled environments. However, much more attention has been paid to biomass enhancement, and elevated CO2 effects on nutrient quality are less recognized. Among the nutrients, Zinc (Zn) and Iron (Fe) are essential elements in humans. Previous studies have demonstrated a decreasing trend of Zn and Fe in main crops such as wheat and rice with increased CO2, while less is known about whether this alleviation effect on Zn and Fe can apply to vegetables. Therefore, a meta-analysis was conducted in this study to evaluate the influence of elevated CO2 concentration in the atmosphere on vegetable Fe and Zn status, and quantify the potential impact of future climate on nutrition security.
|
|
| 20. |
- Wang, Xin-Xin, et al.
(författare)
-
What is the Role of Nb on Preferential Hydriding of Double-Phased Uranium, Stabilizing gamma-U, or Avoiding Hydrogen Aggregation?
- 2021
-
Ingår i: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 125:17, s. 9364-9370
-
Tidskriftsartikel (refereegranskat)abstract
- Uranium as the heaviest naturally occurring element plays important roles in nuclear industries. Hydrogen-caused corrosions and irradiation-caused structural damages are two critical degradations that threaten the safe storage and practical applications of uranium. Through alloying with transition metals like Nb, the gamma-phase of U can be stabilized at room temperature, which shows better performance against hydrogen-caused corrosions than the ground-state alpha-U. The underlying mechanisms have not been fully understood yet. To explain the preferential hydriding phenomenon observed on a specially fabricated double-phase U-2.5 wt % Nb alloy, we perform multiscale ab initio calculations and kinetic Monte Carlo (KMC) simulations. We find that because of different diffusion mechanisms, intrinsic alpha-U and gamma-U already show different hydrogen accumulation behaviors. The existence of random Nb atoms further inhibits hydrogen accumulation in gamma-U. Our work declares its contribution by pointing out the important role of crystal lattice architectures on hydrogen accumulations in metals.
|
|
| 21. |
- Xie, Yi, et al.
(författare)
-
Novel Mesoscale Electrothermal Modeling for Lithium-Ion Batteries
- 2020
-
Ingår i: IEEE Transactions on Power Electronics. - 0885-8993 .- 1941-0107. ; 35:3, s. 2595-2614
-
Tidskriftsartikel (refereegranskat)abstract
- This paper devises an innovative mesoscale electrothermal model for Li-ion batteries. This model manipulates the mesoscale calculation grid in finite element analysis as independent small cell sandwiches and establishes a lumped equivalent circuit model for each cell sandwich. Then, such electrical models are arranged in parallel to form a multilayer equivalent circuit to simulate electrical characteristics of a whole battery, through capturing the current and terminal voltage of each constituent cell sandwich. This modeling idea overcomes the entrenched disadvantage of heat generation models with lumped parameters, i.e., the unavailability of heat generation distribution inside a battery. Besides the current and terminal voltage, the temperature and state of charge dependent open-circuit voltage and entropy coefficient are incorporated into a Newman's heat generation model to estimate the heat generated in the calculation grid. The battery temperature distribution is eventually derived by solving the heat conduction equation with thermal conductivity as a function of the battery temperature. We leverage the developed electrothermal model to track the temperature evolution of an 18650 Li-ion battery at different ambient temperatures and discharge rates, for the first time. Experimental results demonstrate that the electrothermal model can precisely emulate the battery thermal dynamics with an average error of 0.72 °C. Moreover, a comparative study shows that the proposed model outperforms common resistance-based thermal models that do not consider the heat generation distribution and the interdependence between the battery temperature and thermal conductivity.
|
|
| 22. |
- Yi, Peng, et al.
(författare)
-
Late Holocene pathway of Asian Summer Monsoons imprinted in soils and societal implications
- 2019
-
Ingår i: Quaternary Science Reviews. - : Elsevier. - 0277-3791 .- 1873-457X. ; 215, s. 35-44
-
Tidskriftsartikel (refereegranskat)abstract
- The Asian Summer Monsoons (ASM) represent the main source of precipitation in China and East Asia with about one third of the world population and a region of widespread civilizations. Identifying the temporal and spatial patterns (pathways) of these monsoonal events during the Late Holocene to today has been a matter of debate amongst the scientific community. Here we show that the distribution patterns of the cosmogenic isotope Be-10 and oceanic I-127 in the topsoil across China exhibit imprints of the main ASM pathways. Our results indicate the monsoon pathway pattern persisted for several millennia or more and suggest a strong bond between Be-10 and water vapor transport patterns. Our data also reveal a(127)I distribution pattern controlled by the ASM pathways, rather than proximity to the sea or bedrock weathering. The persistent pathway of the ASM during the late Holocene, together with higher than average global soil iodine concentration, may have further strengthened the development of civilizations in this region of the world through reduction of iodine deficiency related diseases. (C) 2019 Elsevier Ltd. All rights reserved.
|
|
| 23. |
- Yu, Lili, et al.
(författare)
-
GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease : Mendelian Randomization and Polygenic Risk Score Analysis
- 2022
-
Ingår i: Frontiers in Genetics. - : Frontiers Media S.A.. - 1664-8021. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- Growth differentiation factor 15 (GDF-15) levels have been revealed as a robust biomarker for metformin use. We conducted Mendelian randomization (MR) analysis to explore the association between GDF-15 and gallstone disease to inform potential therapeutic effects targeting GDF-15. Four genetic variants associated with GDF-15 levels at p < 5 x 10(-8) were selected as instrumental variables from a genome-wide association meta-analysis including 21,758 individuals. Two-sample MR analysis was conducted using summary-level data from UK Biobank (10,520 gallstone cases and 350,674 controls) and FinnGen consortium (19,023 gallstone cases and 195,144 controls). Polygenic risk score analysis using individual-level data in UK biobank was performed to complement the MR findings by examining the non-linearity of the association. Diabetic complications were taken as positive controls to validate the therapeutic effect of targeting GDF-15. Linear and nonlinear associations between genetically predicted GDF-15 levels and gallstones were estimated with stratification by the diabetic status. In the two-sample MR analysis, the odds ratio (OR) of gallstones was 1.09 (95% confidence interval (CI), 1.03-1.15; p = 0.001) for one standard deviation increase in genetically predicted GDF-15 levels in the meta-analysis of two datasets. Polygenic risk score analysis found this association to be U-shaped (p = 0.037). The observed association was predominantly seen in nondiabetic population (OR = 1.11, 95% CI: 1.01-1.21; p = 0.003). An inverse association between genetically predicted GDF-15 levels and diabetic complications (OR = 0.77, 95% CI: 0.62-0.96; p = 0.023) was observed, validating the potential therapeutic effects of targeting GDF-15 levels. This MR study indicates that the increased risk of gallstone disease should be taken into account when considering GDF-15 as a therapeutic target for diabetic complications.
|
|
| 24. |
- Yu, Xiaolin, et al.
(författare)
-
Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity
- 2024
-
Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- Secreted chemokines form concentration gradients in target tissues to control migratory directions and patterns of immune cells in response to inflammatory stimulation; however, how the gradients are formed is much debated. Heparan sulfate (HS) binds to chemokines and modulates their activities. In this study, we investigated the roles of HS in the gradient formation and chemoattractant activity of CCL5 that is known to bind to HS. CCL5 and heparin underwent liquid-liquid phase separation and formed gradient, which was confirmed using CCL5 immobilized on heparin-beads. The biological implication of HS in CCL5 gradient formation was established in CHO-K1 (wild-type) and CHO-677 (lacking HS) cells by Transwell assay. The effect of HS on CCL5 chemoattractant activity was further proved by Transwell assay of human peripheral blood cells. Finally, peritoneal injection of the chemokines into mice showed reduced recruitment of inflammatory cells either by mutant CCL5 (lacking heparin-binding sequence) or by addition of heparin to wild-type CCL5. Our experimental data propose that co-phase separation of CCL5 with HS establishes a specific chemokine concentration gradient to trigger directional cell migration. The results warrant further investigation on other heparin-binding chemokines and allows for a more elaborate insight into disease process and new treatment strategies.
|
|
| 25. |
- Yu, Xiaoshuang, et al.
(författare)
-
Organic Eu3+-complex-anchored porous diatomite channels enable UV protection and down conversion in hybrid material
- 2020
-
Ingår i: Science and Technology of Advanced Materials. - : TAYLOR & FRANCIS LTD. - 1468-6996 .- 1878-5514. ; 21:1, s. 726-736
-
Tidskriftsartikel (refereegranskat)abstract
- The organic Eu3+-complex [Eu(TTA)(3)Phen] has been incorporated into the channels of surface-modified frustules from diatoms as a key material to absorb and convert UV-photons to visible luminescence. Systematic investigation results indicate that the organic Eu3+-complex encapsulated in the functionalized diatomite channels exhibits enhanced luminescence and longer lifetime, owning to the Eu(TTA)(3)Phen complex interacting with its surrounding silylating agents. The organic Eu3+-complex-anchored porous diatomite hybrid luminescent material was compounded with polyethylene terephthalate (PET) by using a mini-twin screw extruder to prepare a self-supporting film of the hybrid material. Besides, the UV absorption properties of the composite films were investigated. These films will potentially be related to the UV protection of photovoltaic devices.
|
|
| 26. |
- Yuan, Shuai, et al.
(författare)
-
Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
- 2023
-
Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 89
-
Tidskriftsartikel (refereegranskat)abstract
- Background: To explore the associations of genetically proxied TYK2 inhibition with a wide range of disease outcomes and biomarkers to identify therapeutic repurposing opportunities, adverse effects, and biomarkers of efficacy.Methods: The loss-of-function missense variant rs34536443 in TYK2 gene was used as a genetic instrument to proxy the effect of TYK2 inhibition. A phenome-wide Mendelian randomization (MR) study was conducted to explore the associations of genetically-proxied TYK2 inhibition with 1473 disease outcomes in UK Biobank (N = 339,197). Identified associations were examined for replication in FinnGen (N = 260,405). We further performed tissue -specific gene expression MR, colocalization analyses, and MR with 247 blood biomarkers. A systematic review of randomized controlled trials (RCTs) on TYK2 inhibitor was performed to complement the genetic evidence.Findings: PheWAS-MR found that genetically-proxied TYK2 inhibition was associated with lower risk of a wide range of autoimmune diseases. The associations with hypothyroidism and psoriasis were confirmed in MR analysis of tissue-specific TYK2 gene expression and the associations with systemic lupus erythematosus, psoriasis, and rheumatoid arthritis were observed in colocalization analysis. There were nominal associations of genetically-proxied TYK2 inhibition with increased risk of prostate and breast cancer but not in tissue-specific expression MR or colocalization analyses. Thirty-seven blood biomarkers were associated with the TYK2 loss-of-function mutation. Evidence from RCTs confirmed the effectiveness of TYK2 inhibitors on plaque psoriasis and reported several adverse effects.Interpretation: This study supports TYK2 inhibitor as a potential treatment for psoriasis and several other autoim-mune diseases. Increased pharmacovigilance is warranted in relation to the potential adverse effects.
|
|
| 27. |
- Zhang, Xiaolin, et al.
(författare)
-
Non-conjugated natural alginate as electron-transport layer for high performance polymer solar cells after modification
- 2021
-
Ingår i: Journal of Power Sources. - : ELSEVIER. - 0378-7753 .- 1873-2755. ; 510
-
Tidskriftsartikel (refereegranskat)abstract
- The search for the alternatives to expensive synthesized conjugated polymers as interfaces in polymer solar cells (PSCs), which could largely decrease the cost and promote the commercialization process of PSCs, is now highly relevant. To introduce natural polymer as the interface layer for the high-efficiency PSCs would be a potential choice. In this study, a purely natural polysaccharide from ocean without any conjugated structure, sodium alginate (SA), is utilized as efficient electron transport layer (ETL) to replace the conjugated star molecule, poly [(9,9-bis(3-(N,NdiMethyl)-NethylaMMoiniuM-propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)]dibroMide (PFN-Br), and modify the aluminum (Al) electrode in conventional PSCs. The reduction of the work function of Al is successfully achieved by SA forming a dipole and keeping the ohmic contact at the interface. Meantime, the ideal charge transfer and exciton dissociation are realized, along with decreasing charge recombination, resulting in a comparable power conversion efficiency (PCE) with devices of PFN-Br as ETL. For poly([2,6-4,8-di(5-ethylhexylthienyebenzo[1,2-b; 3,3-b]dithiophene]3-fluoro-2[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl):[6,6]-phenyl-C-71-butyric acid methyl ester (PTB7-Th:PC71BM) system, PCE is increased to 9.5% and for Poly [(2,6-(4,8-bis(5-(2-ethylhexyl-3-fluoro)thiophen-2-yl)-benzo[1,2-b:4,5-b]dithio-phene))-alt-(5,5-(1,3-di-2-thienyl-5,7-bis(2-ethylhexyl)benzo[1,2-c:4,5-c]dithio-phene-4,8-dione)]:3,9-bis(2methylene-((3-(1,1-dicyanomethylene)-6,7-difluoro)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2,3-d]-s-inda-ceno[1,2-b:5,6-b] dithiophene (PM6:IT-4F) system, PCE 13.4%, respectively, which illustrates a promising future for photovoltaic research of natural alginate non-conjugated polyelectrolyte in conventional PSCs.
|
|
