| 1. |
|
|
| 2. |
|
|
| 3. |
- Deetjen, P, et al.
(författare)
-
Säure-Base-Haushalt aus der Perspektive von P. Stewart : [Interpreting acid-base balance using the Stewart approach.]
- 2007
-
Ingår i: Anaesthesist. - : Springer Science and Business Media LLC. - 0003-2417 .- 1432-055X. ; 56:11, s. 1185-1200
-
Tidskriftsartikel (refereegranskat)abstract
- We have used the Stewart approach to typical acute and compensated acid-base disorders here. Dedicated software developed by the author is available with this article and will be of help to anyone considering analyzing his or her own patients using the Stewart approach. The Stewart approach shares analytical steps with the more traditional Siggard-Andersen method, and in most cases the two methods arrive at the same therapeutic solutions. The Stewart approach is, however, more than merely a biophysical appendix to the traditional clinical model, since metabolic acid-base disorders in particular are understood within a completely different pathophysiological framework; this results in a fresh and sometimes unexpectedly helpful perspective that highlights the functional relevance of seemingly forgotten components such as the chloride ion or albumin.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Lichtwarck-Aschoff, Michael, et al.
(författare)
-
Static versus dynamic respiratory mechanics for setting the ventilator.
- 2000
-
Ingår i: British Journal of Anaesthesia. - 0007-0912 .- 1471-6771. ; 85:4, s. 577-86
-
Tidskriftsartikel (refereegranskat)abstract
- The lower inflection point (LIP) of the inspiratory limb of a static pressure-volume (PV) loop is assumed to indicate the pressure at which most lung units are recruited. The LIP is determined by a static manoeuvre with a PV-history that is different from the PV-history of the actual ventilation. In nine surfactant-deficient piglets, information to allow setting PEEP and VT was obtained, both from the PV-curve and also during ongoing ventilation from the dynamic compliance relationship. According to LIP, PEEP was set at 20 (95% confidence interval 17-22) cm H2O. Volume-dependent dynamic compliance suggested a PEEP reduction (to 15 (13-18) cm H2O). Pulmonary gas exchange remained satisfactory and this change resulted in reduced mechanical stress on the respiratory system, indirectly indicated by volume-dependent compliance being consistently great during the entire inspiration.
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Schumann, S., et al.
(författare)
-
Determination of respiratory system mechanics during inspiration and expiration by FLow-controlled EXpiration (FLEX) : a pilot study in anesthetized pigs
- 2014
-
Ingår i: Minerva Anestesiologica. - 0375-9393 .- 1827-1596. ; 80:1, s. 19-28
-
Tidskriftsartikel (refereegranskat)abstract
- Background. Differences between inspiratory and expiratory lung mechanics result in the hysteresis of the pressure volume-loop. While hysteresis area is a global parameter describing the difference between inspiration and expiration in mechanics under quasi-static conditions, a detailed analysis of this difference under the dynamic conditions of mechanical ventilation is feasible once inspiratory and expiratory compliance (C-in/C-ex) are determined separately. This requires uncoupling of expiratory flow rate and volume (V). Methods. Five piglets were mechanically ventilated at positive end-expiratory pressure (PEEP) levels ranging from 0 to 15 cmH(2)O. Expiratory flow rate was linearized by a computer-controlled resistor (flow-controlled expiration). The volume-dependent C-in(V) and C-ex(V) profiles were calculated from the tracheal pressure volume-loops. Results. The intratidal curve-progression of C-ex(V) was altogether higher with a steeper slope compared to C-in(V). With increasing positive end-expiratory pressure (PEEP) dynamic hysteresis area decreased and C-ex(V) tended to run more parallel to C-in(V), Conclusion. The relation between inspiratory and expiratory compliance profiles is associated with the hysteresis area and behaves PEEP dependent. Analysing the C-in-C-ex-relation might therefore potentially offer a new approach to titrate PEEP and tidal volume.
|
|
| 22. |
|
|
| 23. |
|
|
