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Sökning: WFRF:(Liddle Jennifer)

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1.
  • Lengyel, Denise, et al. (författare)
  • Hands-On Workshop on Tabletop Role-Playing for Inclusive Design: Imagining Sustainable Futures for Older Adults'
  • 2023
  • Ingår i: ACM International Conference Proceeding Series. - 9798400708749 ; , s. 289-293
  • Konferensbidrag (refereegranskat)abstract
    • Older adults' are often seen as a homogeneous group, disregarding their actual diversity in attitudes, abilities, and needs. This stereotypical view can seep into the research and design of digital technologies when developing for this age group, which can lead to those technologies not matching up with actual needs and abilities and thus not being picked up or engaged with. The goal of this workshop is to explore Tabletop Role-Playing Games (TTRPGs) as a method for HCI/UX to promote reflection on the concept of older adults' and to raise awareness for the heterogeneity of this demographic. The TTRPG adventure will be set in a sustainable future where a socio-ecological transformation has taken place; a transformation that can be significantly aided by digital technologies, which additionally stresses the need for a deeper reflection on the heterogeneity of all demographics involved in such a transformation, including older adults'. This workshop will contribute to an improved understanding of TTRPG as an approach to understanding diversity, paving the way to further research into inclusive design of digital technology for sustainability and beyond.
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2.
  • Sawcer, Stephen, et al. (författare)
  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
  • 2011
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 476:7359, s. 214-219
  • Tidskriftsartikel (refereegranskat)abstract
    • Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis.
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