| 1. |
- Wang, H. D., et al.
(författare)
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Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016
- 2017
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Ingår i: Lancet. - 0140-6736 .- 1474-547X. ; 390:10100, s. 1084-1150
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Tidskriftsartikel (refereegranskat)abstract
- Background Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0.5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Sociodemographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates-a measure of relative inequality-increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86.9 years (95% UI 86.7-87.2), and for men in Singapore, at 81.3 years (78.8-83.7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled. Copyright (C) The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 2. |
- Aaltonen, T., et al.
(författare)
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Combination of Tevatron Searches for the Standard Model Higgs Boson in the W+W- Decay Mode
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061802-
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Tidskriftsartikel (refereegranskat)abstract
- We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L.
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| 3. |
- Abazov, V. M., et al.
(författare)
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b-Jet identification in the D0 experiment
- 2010
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 620:2-3, s. 490-517
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Tidskriftsartikel (refereegranskat)abstract
- Algorithms distinguishing jets originating from b quarks from other jet flavors are important tools in the physics program of the D0 experiment at the Fermilab Tevatron p (p) over bar collider. This article describes the methods that have been used to identify b-quark jets, exploiting in particular the long lifetimes of b-flavored hadrons, and the calibration of the performance of these algorithms based on collider data.
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| 4. |
- Abazov, V. M., et al.
(författare)
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Dependence of the t(t)over-bar production cross section on the transverse momentum of the top quark
- 2010
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 693:5, s. 515-521
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the differential cross section for t (t) over bar events produced in p (p) over bar collisions at root s = 1.96 TeV as a function of the transverse momentum (p(T)) of the top quark. The selected events contain a high-p(T) lepton (l), a large imbalance in p(T). four or more jets with at least one candidate for a b jet, and correspond to 1 fb(-1) of integrated luminosity recorded with the D0 detector. Objects in the event are associated through a constrained kinematic fit to the t (t) over bar -> WbW (b) over bar -> lvbq (q) over bar' (b) over bar process. Results from next and next-to-next-to-leading-order perturbative QCD calculations agree with the measured differential cross section. Comparisons are also provided to predictions from Monte Carlo event generators using QCD calculations at different levels of precision. (C) 2010 Elsevier B.V. All rights reserved.
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| 5. |
- Abazov, V. M., et al.
(författare)
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Determination of the strong coupling constant from the inclusive jet cross section in pp collisions at s=1.96 TeV
- 2009
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Ingår i: PHYS REV D. - 1550-7998 .- 1550-2368. ; 80, s. 111107-
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Tidskriftsartikel (refereegranskat)abstract
- We determine the strong coupling constant alpha(s) and its energy dependence from the p(T) dependence of the inclusive jet cross section in pp collisions at s=1.96 TeV. The strong coupling constant is determined over the transverse momentum range 50 < p(T)< 145 GeV. Using perturbative QCD calculations to order O(alpha(3)(s)) combined with O(alpha(4)(s)) contributions from threshold corrections, we obtain alpha(s)(M-Z)=0.1161(-0.0048)(+0.0041). This is the most precise result obtained at a hadron-hadron collider.
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| 6. |
- Abazov, V. M., et al.
(författare)
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Determination of the Width of the Top Quark
- 2011
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 106:2, s. 022001-
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Tidskriftsartikel (refereegranskat)abstract
- We extract the total width of the top quark, Gamma(t), from the partial decay width Gamma(t -> Wb) measured using the t-channel cross section for single top-quark production and from the branching fraction B(t -> Wb) measured in t (t) over bar t events using up to 2.3 fb(-1) of integrated luminosity collected by the D0 Collaboration at the Tevatron p (p) over bar Collider. The result is Gamma(t) = 1.99(-0.55)(+0.69) GeV, which translates to a top-quark lifetime of tau(t) = (3.3-(+1.3)(0.9)) x 10(-25) s. Assuming a high mass fourth generation b' quark and unitarity of the four-generation quark-mixing matrix, we set the first upper limit on vertical bar V-tb'vertical bar < 0.63 at 95% C.L.
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| 7. |
- Abazov, V. M., et al.
(författare)
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Double parton interactions in gamma+3 jet events in p(p)over-bar collisions at root s=1.96 TeV
- 2010
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 81:5, s. 052012-
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Tidskriftsartikel (refereegranskat)abstract
- We have used a sample of gamma + 3 jets events collected by the D0 experiment with an integrated luminosity of about 1 fb(-1) to determine the fraction of events with double parton scattering (f(DP)) in a single p (p) over bar collision at root s = 1.96 TeV. The DP fraction and effective cross section (sigma(eff)), a process-independent scale parameter related to the parton density inside the nucleon, are measured in three intervals of the second (ordered in p(T)) jet transverse momentum p(T)(jet2) within the range 15 <= p(T)(jet2) <= 30 GeV. In this range, f(DP) varies between 0.23 <= f(DP) <= 0.47, while sigma(eff) has the average value sigma(ave)(eff) = 16.4 +/- 0.3(stat) +/- 2.3(syst) mb.
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| 8. |
- Abazov, V. M., et al.
(författare)
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Evidence for an anomalous like-sign dimuon charge asymmetry
- 2010
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Ingår i: Physical Review D. - 1550-7998. ; 82:13, s. 032001-
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Tidskriftsartikel (refereegranskat)abstract
- We measure the charge asymmetry A of like-sign dimuon events in 6.1 fb(-1) of p (p) over bar collisions recorded with the D0 detector at a center-of-mass energy root s = 1.96 TeV at the Fermilab Tevatron collider. From A, we extract the like-sign dimuon charge asymmetry in semileptonic b-hadron decays: A(sl)(b) = -0.00957 +/- 0.00251 (stat) +/- 0.00146 (syst). This result differs by 3.2 standard deviations from the standard model prediction A(sl)(b)(SM) = (-2.3(0.6)(+0.5)) x 10(-4) and provides first evidence of anomalous CP violation in the mixing of neutral B mesons.
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| 9. |
- Abazov, V. M., et al.
(författare)
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Evidence for an Anomalous Like-Sign Dimuon Charge Asymmetry
- 2010
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:8, s. 081801-
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Tidskriftsartikel (refereegranskat)abstract
- We measure the charge asymmetry A =(N++ -N--)/(N++ + N--) of like-sign dimuon events in 6.1 fb(-1) of p (p) over bar collisions recorded with the D0 detector at a center-of-mass energy root s = 1: 96 TeV at the Fermilab Tevatron collider. From A we extract the like-sign dimuon charge asymmetry in semileptonic b-hadron decays: A(sl)(b) = -0.009 57 +/- 0.00251(stat) +/- 0.001 46(sys). It differs by 3.2 standard deviations from the standard model prediction A(sl)(b)(SM) = (-2.3(-0.6)(+0.5)) x 10(-4), and provides first evidence of anomalous CP violation in the mixing of neutral B mesons.
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| 10. |
- Abazov, V. M., et al.
(författare)
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Evidence for the Decay B-s(0)->(DsDs(*))-D-(*) and a Measurement of Delta Gamma(CP)(s)/Gamma(s)
- 2009
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:9, s. 091801-
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Tidskriftsartikel (refereegranskat)abstract
- We search for the semi-inclusive process B-s(0)->(DsDs(*))-D-(*) using 2.8 fb(-1) of pp collisions at s=1.96 TeV recorded by the D0 detector operating at the Fermilab Tevatron Collider. We observe 26.6 +/- 8.4 signal events with a significance above background of 3.2 standard deviations yielding a branching ratio of B(B-s(0)->(DsDs(*))-D-(*))=0.035 +/- 0.010(stat.)+/- 0.011(syst.). Under certain theoretical assumptions, these double-charm final states saturate CP-even eigenstates in the B-s(0) decays resulting in a width difference of Delta Gamma(CP)(s)/Gamma(s)=0.072 +/- 0.021(stat.)+/- 0.022(syst.).
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| 11. |
- Abazov, V. M., et al.
(författare)
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High mass exclusive diffractive dijet production in p(p)over-bar collisions at root s=1.96 TeV
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 705:3, s. 193-199
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Tidskriftsartikel (refereegranskat)abstract
- We present evidence for diffractive exclusive dijet production with an invariant dijet mass greater than 100 GeV in data collected with the DO experiment at the Fermilab Tevatron Collider. A discriminant based on calorimeter information is used to measure a significant number of events with little energy (typically less than 10 GeV) outside the dijet system, consistent with the diffractive exclusive dijet production topology. The probability for these events to be explained by other dijet production processes is 2 x 10(-6), corresponding to a 4.7 standard deviation significance.
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| 12. |
- Abazov, V. M., et al.
(författare)
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Measurement of direct photon pair production cross sections in p(p)over-bar collisions at root s=1.96 TeV
- 2010
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 690:2, s. 108-117
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of direct photon pair production cross sections using 4.2 fb(-1) of data collected with the DO detector at the Fermilab Tevatron p (p) over bar Collider. We measure single differential cross sections as a function of the diphoton mass, the transverse momentum of the diphoton system, the azimuthal angle between the photons, and the polar scattering angle of the photons. In addition, we measure double differential cross sections considering the last three kinematic variables in three diphoton mass bins. The results are compared with different perturbative QCD predictions and event generators. (C) 2010 Elsevier B.V. All rights reserved.
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| 13. |
- Abazov, V. M., et al.
(författare)
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Measurement of sigma(p(p)over-bar -> Z plus X)Br(Z -> tau(+)tau(-)) at root s=1.96 TeV
- 2009
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 670:4-5, s. 292-299
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the cross section for Z boson production times the branching fraction to tau lepton pairs sigma(p (p) over bar -> Z + X)Br(Z -> tau(+)tau(-)) in p (p) over bar collisions at root s = 1.96 TeV. The measurement is performed in the channel in which one tau lepton decays into a muon and neutrinos. and the other tau lepton decays hadronically or into an electron and neutrinos. The data sample corresponds to an integrated luminosity of 1.0 fb(-1) collected with the DO detector at the Fermilab Tevatron Collider. The sample contains 1511 candidate events with an estimated 20% background from jets or muons misidentified as tau leptons. We obtain sigma . Br = 240 +/- 8 (star) +/- 12 (sys) +/- 15 (lum) pb, which is consistent with the standard model prediction.
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| 14. |
- Abazov, V. M., et al.
(författare)
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Measurement of t(t)over-bar production in the tau plus jets topology using p(p)over-bar collisions root s=1.96 TeV
- 2010
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Ingår i: PHYS REV D. - 1550-7998. ; 82:7, s. 071102-
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the t (t) over bar production cross section multiplied by the branching ratio to tau lepton decaying semihadronically (tau(h)) plus jets, sigma(p (p) over bar -> t (t) over bar + X) center dot BR(t (t) over bar -> tau(h) + jets), at a center of mass energy root s = 1.96 TeV using 1 fb(-1) of integrated luminosity collected with the D0 detector. Assuming a top quark mass of 170 GeV, we measure sigma(t (t) over bar) center dot BR tau h (+ j) = 0.60(-0.22)(+0.23)(stat)(-0.14)(+0.15)(syst) +/- 0.04(lumi) pb. In addition, we extract the t (t) over bar production cross section using the t (t) over bar -> tau(h) + jets topology, with the result sigma(t (t) over bar) = 6.9(-1.2)(+1.2)(stat)(-0.7)(+0.8)(syst) +/- 0.4(lumi) pb. These findings are in good agreement with standard model predictions and measurements performed using other top quark decay channels.
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| 15. |
- Abazov, V. M., et al.
(författare)
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Measurement of the Angular and Lifetime Parameters of the Decays B-d(0) -> J/psi K*(0) and B-s(0) -> J/psi phi
- 2009
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:3, s. 032001-:102, s. 032001-
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the linear polarization amplitudes and the strong relative phases that describe the flavor-untagged decays B-d(0) --> J/psi K*(0) and B-s(0) --> J/psi phi in the transversity basis. We also measure the mean lifetime (tau) over bar (s) of the B-s(0) mass eigenstates and the lifetime ratio (tau) over bar (s)/tau(d). The analyses are based on approximately 2.8 fb(-1) of data recorded with the D0 detector. From our measurements of the angular parameters we conclude that there is no evidence for a deviation from flavor SU( 3) symmetry for these decays and that the factorization assumption is not valid for the B-d(0) --> J/psi K*(0) decay.
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| 16. |
- Abazov, V. M., et al.
(författare)
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Measurement of the dijet invariant mass cross section in p(p)over-bar collisions at root s=1.96 TeV
- 2010
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 693:5, s. 531-538
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Tidskriftsartikel (refereegranskat)abstract
- The inclusive dijet production double differential cross section as a function of the dijet invariant mass and of the largest absolute rapidity of the two jets with the largest transverse momentum in an event is measured in p (p) over bar collisions at root s = 1.96 TeV using 0.7 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron Collider. The measurement is performed in six rapidity regions up to a maximum rapidity of 2.4. Next-to-leading order perturbative QCD predictions are found to be in agreement with the data. (C) 2010 Elsevier B.V. All rights reserved.
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| 17. |
- Abazov, V. M., et al.
(författare)
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Measurement of the normalized Z/gamma* -> mu(+)mu(-) transverse momentum distribution in p(p)over-bar collisions at root s=1.96 TeV
- 2010
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 693:5, s. 522-530
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Tidskriftsartikel (refereegranskat)abstract
- We present a new measurement of the Z/gamma* transverse momentum distribution in the range 0-330 GeV, in proton-antiproton collisions at root s = 1.96 TeV. The measurement uses 0.97 fb(-1) of integrated luminosity recorded by the D0 experiment and is the first using the Z/gamma* -> mu(+)mu(-) + X channel at this center-of-mass energy. This is also the first measurement of the Z/gamma* transverse momentum distribution that presents the result at the level of particles entering the detector, minimizing dependence on theoretical models. As any momentum of the Z/gamma* in the plane transverse to the incoming beams must be balanced by some recoiling system, primarily the result of QCD radiation in the initial state, this variable is an excellent probe of the underlying process. Tests of the predictions of QCD calculations and current event generators show they have varied success in describing the data. Using this measurement as an input to theoretical predictions will allow for a better description of hadron collider data and hence it will increase experimental sensitivity to rare signals. (C) 2010 Elsevier B.V. All rights reserved.
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| 18. |
- Abazov, V. M., et al.
(författare)
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Measurement of the t-channel single top quark production cross section
- 2010
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:4-5, s. 363-369
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Tidskriftsartikel (refereegranskat)abstract
- The DO Collaboration reports direct evidence for electroweak production of single top quarks through the t-channel exchange of a virtual W boson. This is the first analysis to isolate an individual single top quark production channel. We select events containing an isolated electron or muon, missing transverse energy, and two, three or four jets from 2.3 fb(-1) of p (p) over bar collisions at the Fermilab Tevatron Collider. One or two of the jets are identified as containing a b hadron. We combine three multivariate techniques optimized for the t-channel process to measure the t- and s-channel cross sections simultaneously. We measure cross sections of 3.14(-0.80)(+0.94) pb for the t-channel and 1.05 +/- 0.81 pb for the s-channel. The measured t-channel result is found to have a significance of 4.8 standard deviations and is consistent with the standard model prediction.
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| 19. |
- Abazov, V. M., et al.
(författare)
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Measurement of the t(t)over-bar cross section using high-multiplicity jet events
- 2010
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 82, s. 032002-
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the t (t) over bar cross section using high-multiplicity jet events produced in p (p) over bar collisions at root s = 1.96 TeV. These data were recorded at the Fermilab Tevatron Collider with the D0 detector. Events with at least six jets, two of them identified as b jets, were selected from a 1 fb(-1) data set. The measured cross section, assuming a top quark mass of 175 GeV/c(2), is 6.9 +/- 2.0 pb, in agreement with theoretical expectations.
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| 20. |
- Abazov, V. M., et al.
(författare)
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Measurement of the top quark mass in final states with two leptons
- 2009
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 80, s. 092006-
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the top quark mass (m(t)) in tt candidate events with two final state leptons using 1 fb(-1) of data collected by the D0 experiment. Our data sample is selected by requiring two fully identified leptons or by relaxing one lepton requirement to an isolated track if at least one jet is tagged as a b jet. The top quark mass is extracted after reconstructing the event kinematics under the tt hypothesis using two methods. In the first method, we integrate over expected neutrino rapidity distributions, and in the second we calculate a weight for the possible top quark masses based on the observed particle momenta and the known parton distribution functions. We analyze 83 candidate events in the data and obtain m(t)=176.2 +/- 4.8(stat)+/- 2.1(sys) GeV and m(t)=173.2 +/- 4.9(stat)+/- 2.0(sys) GeV for the two methods, respectively. Accounting for correlations between the two methods, we combine the measurements to obtain m(t)=174.7 +/- 4.4(stat)+/- 2.0(sys) GeV.
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| 21. |
- Abazov, V. M., et al.
(författare)
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Measurement of the WZ -> lvll cross section and limits on anomalous triple gauge couplings in p(p)over-bar collisions at root s=1.96 TeV
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 695:1-4, s. 67-73
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Tidskriftsartikel (refereegranskat)abstract
- We present a new measurement of the WZ -> lvll (l = e, mu) cross section and limits on anomalous triple gauge couplings. Using 4.1 fb(-1) of integrated luminosity of p (p) over bar collisions at root s = 1.96 TeV, we observe 34 WZ candidate events with an estimated background of 6.0 +/- 0.4 events. We measure the WZ production cross section to be 3.89(-0.90)(+1.07) pb, in good agreement with the standard model prediction. We find no evidence for anomalous WWZ couplings and set 95% C.L. limits on the coupling parameters, -0.077 < lambda(z) < 0.093 and -0.029 < Delta kappa(z) < 0.080 in the HISZ parameterization for a Lambda = 2 TeV form factor scale. These are the best limits to date obtained from the direct measurement of the WWZ vertex.
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| 22. |
- Abazov, V. M., et al.
(författare)
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Measurement of Z/gamma* plus jet plus X angular distributions in p(p)over-bar collisions at root s=1.96 TeV
- 2010
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:4-5, s. 370-380
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Tidskriftsartikel (refereegranskat)abstract
- We present the first measurements at a hadron collider of differential cross sections for Z/gamma* + jet + X production in Delta phi(Z. jet), vertical bar Delta y(Z, jet)vertical bar and vertical bar y(boost)(Z + jet)vertical bar. Vector boson production in association with jets is an excellent probe of QCD and constitutes the main background to many small cross section processes, such as associated Higgs production. These measurements are crucial tests of the predictions of perturbative QCD and current event generators, which have varied success in describing the data. Using these measurements as inputs in tuning event generators will increase the experimental sensitivity to rare signals.
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| 23. |
- Abazov, V. M., et al.
(författare)
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Observation of ZZ Production in p(p)over-bar Collisions at root s=1.96 TeV
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 101:17, s. 171803-:101, s. 171803-
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Tidskriftsartikel (refereegranskat)abstract
- We present an observation for ZZ -> l(+) l(-) l'(+) l'(-) (l, l' =e or mu) production in p (p) over bar collisions at a center-of-mass energy of root s = 1.96 TeV. Using 1.7 fb(-1) of data collected by the D0 experiment at the Fermilab Tevatron Collider, we observe three candidate events with an expected background of 0.14(-0.02)(+0.03) events. The significance of this observation is 5.3 standard deviations. The combination of D0 results in this channel, as well as in ZZ -> l(+) l(-) v (v) over bar yields a significance of 5.7 standard deviations and a combined cross section of sigma(ZZ) = 1.60 +/- 0.63(stat)(-0.17)(+0.16)(syst) pb.
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| 24. |
- Abazov, V. M., et al.
(författare)
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Precise Study of the Z/gamma* Boson Transverse Momentum Distribution in p(p)over-bar Collisions Using a Novel Technique
- 2011
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 106:12, s. 122001-
-
Tidskriftsartikel (refereegranskat)abstract
- Using 7.3 fb(-1) of p (p) over bar collisions collected by the D0 detector at the Fermilab Tevatron, we measure the distribution of the variable phi(eta)*, which probes the same physical effects as the Z/gamma* boson transverse momentum, but is less susceptible to the effects of experimental resolution and efficiency. A QCD prediction is found to describe the general features of the phi(eta)* distribution, but is unable to describe its detailed shape or dependence on boson rapidity. A prediction that includes a broadening of transverse momentum for small values of the parton momentum fraction is strongly disfavored.
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| 25. |
- Abazov, V. M., et al.
(författare)
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Search for a heavy neutral gauge boson in the dielectron channel with 5.4 fb(-1) of p(p)over-bar collisions at root s=1.96 TeV
- 2011
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 695:1-4, s. 88-94
-
Tidskriftsartikel (refereegranskat)abstract
- We report the results of a search for a heavy neutral gauge boson Z' decaying into the dielectron final state using data corresponding to an integrated luminosity of 5.4 fb(-1) collected by the D0 experiment at the Fermilab Tevatron Collider. No significant excess above the standard model prediction is observed in the dielectron invariant-mass spectrum. We set 95 sigma(p (p) over bar -> Z') x BR(Z' -> ee) depending on the dielectron invariant mass. These cross section limits are used to determine lower mass limits for bosons in a variety of models. For the sequential standard model boson a lower mass limit of 1023 GeV is obtained.
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| 26. |
- Abazov, V. M., et al.
(författare)
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Search for a Resonance Decaying into WZ Boson Pairs in p(p)over-bar Collisions
- 2010
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061801-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first search for an electrically charged resonance W' decaying to a WZ boson pair using 4.1 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron p (p) over bar collider. The WZ pairs are reconstructed through their decays into three charged leptons (l = e, mu). A total of 9 data events is observed in good agreement with the background prediction. We set 95% C.L. limits on the W'WZ coupling and on the W' production cross section multiplied by the branching fractions. We also exclude W' masses between 188 and 520 GeV within a simple extension of the standard model and set the most restrictive limits to date on low-scale technicolor models.
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| 27. |
- Abazov, V. M., et al.
(författare)
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Search for Anomalous Top-Quark Couplings with the D0 Detector
- 2009
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:9, s. 092002-
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Tidskriftsartikel (refereegranskat)abstract
- Anomalous Wtb couplings modify the angular correlations of the top-quark decay products and change the single top-quark production cross section. We present limits on anomalous top-quark couplings by combining information from W boson helicity measurements in top-quark decays and anomalous coupling searches in the single top-quark final state. We set limits on right-handed vector couplings as well as left-handed and right-handed tensor couplings based on about 1 fb(-1) of data collected by the D0 experiment.
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| 28. |
- Abazov, V. M., et al.
(författare)
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Search for Associated W and Higgs Boson Production in p(p)over-bar Collisions at root s=1.96 TeV
- 2009
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:5, s. 051803-:102, s. 051803-
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Tidskriftsartikel (refereegranskat)abstract
- We present results of a search for WH -> l nu b (b) over bar production in p (p) over bar collisions based on the analysis of 1.05 fb(-1) of data collected by the D0 experiment at the Fermilab Tevatron, using a neural network for separating the signal from backgrounds. No signal-like excess is observed, and we set 95% C. L. upper limits on the WH production cross section multiplied by the branching ratio for H -> b (b) over bar for Higgs boson masses between 100 and 150 GeV. For a mass of 115 GeV, we obtain an observed (expected) limit of 1.5 (1.4) pb, a factor of 11.4 (10.7) times larger than the standard model prediction.
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| 29. |
- Abazov, V. M., et al.
(författare)
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Search for charged Higgs bosons in top quark decays
- 2009
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:3, s. 278-286
-
Tidskriftsartikel (refereegranskat)abstract
- We present a search for charged Higgs bosons in top quark decays. We analyze the e + jets, mu + jets, ee, e mu, mu mu, tau e and tau mu final states from top quark pair production events, using data from about 1 fb (1) of integrated luminosity recorded by the DO experiment at the Fermilab Tevatron Collider. We consider different scenarios of possible charged Higgs boson decays, one where the charged Higgs boson decays purely hadronically into a charm and a strange quark, another where it decays into a tau lepton and a tau neutrino and a third one where both decays appear. We extract limits on the branching ratio B(t -> H(+)b) for all these models. We use two methods, one where the t (t) over bar production cross section is fixed, and one where the cross section is fitted simultaneously with B(t -> H(+)b). Based on the extracted limits, we exclude regions in the charged Higgs boson mass and tan beta parameter space for different scenarios of the minimal supersymmetric standard model.
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| 30. |
- Abazov, V. M., et al.
(författare)
-
Search for CP violation in B-s(0) -> mu(+) D-s(-) X decays in p(p)over-bar collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 82:1, s. 012003-
-
Tidskriftsartikel (refereegranskat)abstract
- We have performed a search for CP violation in a sample of B-s(0) -> mu+Ds-X decays corresponding to 5 fb(-1) of proton-antiproton collisions collected by the D0 detector in Run II at the Fermilab Tevatron Collider. New physics in B-s(0) mixing could contribute a significant CP violating weak phase, which would be observed as a difference in the decay-time distribution for B-s(0) -> (B) over bar (0)(s) oscillated states versus that for (B) over bar (0)(s) -> B-s(0). A fit to the decay-time distributions of the B-s(0)/(B) over bar (0)(s) candidates yields the flavor-specific asymmetry as a(fs)(s) = [-1.7 +/- 9.1(stat)(-1.5)(+1.4)(syst) x 10(-3), which excludes CP violation due to new physics within the experimental sensitivity.
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| 31. |
- Abazov, V. M., et al.
(författare)
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Search for Diphoton Events with Large Missing Transverse Energy in 6.3 fb(-1) of p(p)over-bar Collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:22, s. 221802-
-
Tidskriftsartikel (refereegranskat)abstract
- We report a search for diphoton events with large missing transverse energy produced in p (p) over bar collisions at root s = 1.96 TeV. The data were collected with the D0 detector at the Fermilab Tevatron Collider and correspond to 6.3 fb(-1) of integrated luminosity. The observed missing transverse energy distribution is well described by the standard model prediction, and 95% C.L. limits are derived on two realizations of theories beyond the standard model. In a gauge-mediated supersymmetry breaking scenario, the breaking scale Lambda is excluded for Lambda < 124 TeV. In a universal extra dimension model including gravitational decays, the compactification radius R-c is excluded for R-c(-1) < 477 GeV.
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| 32. |
- Abazov, V. M., et al.
(författare)
-
Search for Events with Leptonic Jets and Missing Transverse Energy in p(p)over-bar Collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:21, s. 211802-
-
Tidskriftsartikel (refereegranskat)abstract
- We present the first search for pair production of isolated jets of charged leptons in association with a large imbalance in transverse energy in p (p) over bar collisions using 5: 8 fb(-1) of integrated luminosity collected by the D0 detector at the Fermilab Tevatron Collider. No excess is observed above the standard model background, and the result is used to set upper limits on the production cross section of pairs of supersymmetric chargino and neutralino particles as a function of "dark-photon'' mass, where the dark photon is produced in the decay of the lightest supersymmetric particle.
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| 33. |
- Abazov, V. M., et al.
(författare)
-
Search for flavor changing neutral currents via quark-gluon couplings in single top quark production using 2.3 fb(-1) of p(p)over-bar collisions
- 2010
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 693:2, s. 81-87
-
Tidskriftsartikel (refereegranskat)abstract
- We present a search for flavor changing neutral currents via quark-gluon couplings in a sample of single top quark final states corresponding to 2.3 fb(-1) of integrated luminosity collected with the DO detector at the Fermilab Tevatron Collider. We select events containing a single top quark candidates with an additional jet, and obtain separation between signal and background using Bayesian neural networks. We find consistency between background expectation and observed data, and set limits on flavor changing neutral current gluon couplings of the top quark to up quarks (tgu) and charm quarks (tgc). The cross section limits at the 95% C.L. are sigma(tgu) < 0.20 pb and sigma(tgc) < 0.27 pb. These correspond to limits on the top quark decay branching fractions of B(t -> gu) < 2.0 x 10(-4) and B(t -> gc) < 3.9 x 10(-3).
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| 34. |
- Abazov, V. M., et al.
(författare)
-
Search for Higgs Boson Production in Dilepton and Missing Energy Final States with 5.4 fb(-1) of p(p)over-bar Collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061804-
-
Tidskriftsartikel (refereegranskat)abstract
- A search for the standard model Higgs boson is presented using events with two charged leptons and large missing transverse energy selected from 5.4 fb(-1) of integrated luminosity in p ($) over bar collisions at root s = 1.96 TeV collected with the D0 detector at the Fermilab Tevatron collider. No significant excess of events above background predictions is found, and observed (expected) upper limits at 95% confidence level on the rate of Higgs boson production are derived that are a factor of 1.55 (1.36) above the predicted standard model cross section at m(H) = 165 GeV.
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| 35. |
- Abazov, V. M., et al.
(författare)
-
Search for Large Extra Spatial Dimensions in the Dielectron and Diphoton Channels in p(p)over-bar Collisions at root s=1.96 TeV
- 2009
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:5, s. 051601-:102, s. 051601-
-
Tidskriftsartikel (refereegranskat)abstract
- We report on a search for large extra spatial dimensions in the dielectron and diphoton channels using a data sample of 1: 05 fb(-1) of p (p) over bar collisions at a center-of-mass energy of 1.96 TeV collected by the D0 detector at the Fermilab Tevatron Collider. The invariant mass spectrum of the data agrees well with the prediction of the standard model. We find the most restrictive 95% C. L. lower limits on the effective Planck scale between 2.1 and 1.3 TeV for 2 to 7 extra dimensions.
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| 36. |
- Abazov, V. M., et al.
(författare)
-
Search for Neutral Higgs Bosons at High tan beta in the b(h/H/A) -> b tau(+)tau(-) Channel
- 2009
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:5, s. 051804-:102, s. 051804-
-
Tidskriftsartikel (refereegranskat)abstract
- The first search in p (p) over bar collisions at root s = 1.96 TeV for the production of neutral Higgs bosons in association with bottom quarks and decaying in two tau leptons is presented. The cross section for this process is enhanced in many extensions of the standard model, such as its minimal supersymmetric extension (MSSM) at large tan beta. The data, corresponding to an integrated luminosity of 328 pb(-1), were collected with the D0 detector at the Fermilab Tevatron Collider. An upper limit is set on the production cross section of neutral Higgs bosons in the mass range of 90 to 150 GeV, and this limit is used to exclude part of the MSSM parameter space.
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| 37. |
- Abazov, V. M., et al.
(författare)
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Search for New Fermions ("Quirks'') at the Fermilab Tevatron Collider
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:21, s. 211803-
-
Tidskriftsartikel (refereegranskat)abstract
- We report results of a search for particles with anomalously high ionization in events with a high transverse energy jet and large missing transverse energy in 2: 4 fb(-1) of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron p (p) over bar collider. Production of such particles (quirks) is expected in scenarios with extra QCD-like SU(N) sectors, and this study is the first dedicated search for such signatures. We find no evidence of a signal and set a lower mass limit of 107, 119, and 133 GeV for the mass of a charged quirk with strong dynamics scale Lambda in the range from 10 keV to 1 MeV and N = 2, 3, and 5, respectively.
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| 38. |
- Abazov, V. M., et al.
(författare)
-
Search for pair production of second generation scalar leptoquarks
- 2009
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 671:2, s. 224-232
-
Tidskriftsartikel (refereegranskat)abstract
- We report on a search for the pair production of second generation scalar leptoquarks (LQ) in p (p) over bar collisions at the center of mass energy root s- = 1.96 TeV using a data set corresponding to an integrated luminosity of 1.0 fb(-1) collected with the D empty set experiment at the Fermilab Tevatron Collider. Topologies arising from the LQ (LQ) over bar -> mu q nu q and LQ (LQ) over bar -> mu q mu q decay modes are investigated. No excess of data over the standard model prediction is observed and upper limits on the leptoquark pair production cross section are derived at the 95% C.L. as a function of the leptoquark mass and the branching fraction beta for the decay LQ -> mu q. These are interpreted as lower limits on the leptoquark mass as a function of beta. For beta = 1 (0.5), scalar second generation leptoquarks with masses up to 316 GeV (270 GeV) are excluded.
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| 39. |
- Abazov, V. M., et al.
(författare)
-
Search for pair production of the scalar top quark in the electron plus muon final state
- 2011
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 696:4, s. 321-327
-
Tidskriftsartikel (refereegranskat)abstract
- We report the result of a search for the pair production of the lightest supersymmetric partner of the top quark ((t) over tilde (1)) in p (p) over bar collisions at a center-of-mass energy of 1.96 TeV at the Fermilab Tevatron collider corresponding to an integrated luminosity of 5.4 fb(-1). The scalar top quarks are assumed to decay into a b quark, a charged lepton, and a scalar neutrino ((nu) over bar). and the search is performed in the electron plus muon final state. No significant excess of events above the standard model prediction is detected, and substantially improved exclusion limits at the 95% C.L. are set in the the (M-(t) over tilde1, M-(nu) over tilde mass plane.
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| 40. |
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| 41. |
- Abazov, V. M., et al.
(författare)
-
Search for scalar bottom quarks and third-generation leptoquarks in p(p)over-bar collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 693:2, s. 95-101
-
Tidskriftsartikel (refereegranskat)abstract
- We report the results of a search for pair production of scalar bottom quarks ((b) over bar (1)) and scalar third-generation leptoquarks (LQ(3)) in 5.2 fb(-1) of p (p) over bar collisions at the D0 experiment of the Fermilab Tevatron Collider. Scalar bottom quarks are assumed to decay to a neutralino ((chi) over bar (1)(0)) and a b quark, and we set 95% C.L. lower limits on their production in the (m((b) over bar1), m((chi) over bar 10)) mass plane such as m((b) over bar1) > 247 GeV for m(<(chi)over) (bar>10) = 0 and m((chi) over bar 10) > 110 GeV for 160 m(<(b) over bar1) < 200 GeV. The leptoquarks are assumed to decay to a tau neutrino and a b quark, and we set a 95% C.L. lower limit of 247 GeV on the mass of a charge-1/3 third-generation scalar leptoquark.
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| 42. |
- Abazov, V. M., et al.
(författare)
-
Search for single top quarks in the tau plus jets channel using 4.8 fb(-1) of p(p)over-bar collision data
- 2010
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 690:1, s. 5-14
-
Tidskriftsartikel (refereegranskat)abstract
- We present the first direct search for single top quark production using reconstructed tau leptons in the final state. The search is based on 4.8 fb(-1) of integrated luminosity collected in p (p) over bar collisions at root s= 1.96 TeV with the D0 detector at the Fermilab Tevatron Collider. We select events with a final state including an isolated tau lepton. missing transverse energy, two or three jets, one or two of them being identified as b quark jet. We use a multivariate technique to discriminate signal from background. The number of events observed in data in this final state is consistent with the signal plus background expectation. We set in the tau + jets channel an upper limit on the single top quark cross section of 7.3 pb at the 95% C.L. This measurement allows a gain of 4% in expected sensitivity for the observation of single top production when combining it with electron + jets and muon + jets channels already published by the DO Collaboration with 2.3 fb(-1) of data. We measure a combined cross section of 3.84(-0.83)(+0.89) pb, which is the most precise measurement to date.
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| 43. |
- Abazov, V. M., et al.
(författare)
-
Search for Sneutrino Production in e mu Final States in 5.3 fb(-1) of p(p)over-bar Collisions at root s = 1.96 TeV
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:19, s. 191802-
-
Tidskriftsartikel (refereegranskat)abstract
- We report the results of a search for R parity violating (RPV) interactions leading to the production of supersymmetric sneutrinos decaying into e mu final states using 5.3 fb(-1) of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. Having observed no evidence for production of e mu resonances, we set direct bounds on the RPV couplings lambda'(311) and lambda(312) as a function of sneutrino mass.
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| 44. |
- Abazov, V. M., et al.
(författare)
-
Search for the Associated Production of a b Quark and a Neutral Supersymmetric Higgs Boson that Decays into τ Pairs
- 2010
-
Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 104:15
-
Tidskriftsartikel (refereegranskat)abstract
- We report results from a search for production of a neutral Higgs boson in association with a b quark. We search for Higgs decays to tau pairs with one tau subsequently decaying to a muon and the other to hadrons. The data correspond to 2: 7 fb(-1) of p (p) over bar collisions recorded by the D0 detector at.. root s = 1.96 TeV. The data are found to be consistent with background predictions. The result allows us to exclude a significant region of parameter space of the minimal supersymmetric model.
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| 45. |
- Abazov, V. M., et al.
(författare)
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Search for the rare decay B-s(0) -> mu(+)mu(-)
- 2010
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 693:5, s. 539-544
-
Tidskriftsartikel (refereegranskat)abstract
- We present the results of a search for the flavor changing neutral current decay B-s(0) -> mu(+)mu(-) using 6.1 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV collected by the D0 experiment at the Fermilab Tevatron Collider. The observed number of B-s(0) candidates is consistent with background expectations. The resulting upper limit on the branching fraction is B(B-s(0) -> mu(+)mu(-)) < 5.1 x 10(-8) at the 95% C.L. This limit is a factor of 2.4 better than that of the previous DO analysis and the best limit to date. Published by Elsevier B.V.
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| 46. |
- Abazov, V. M., et al.
(författare)
-
Search for the Standard Model Higgs Boson in the ZH -> v(v)over-barb(b)over-bar Channel in 5.2 fb(-1) of p(p)over-bar Collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:7, s. 071801-
-
Tidskriftsartikel (refereegranskat)abstract
- A search is performed for the standard model Higgs boson in 5.2 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV, collected with the D0 detector at the Fermilab Tevatron Collider. The final state considered is a pair of b jets and large missing transverse energy, as expected from p (p) over bar -> ZH -> v (v) over barb (b) over bar production. The search is also sensitive to the WH -> lvb (b) over bar channel when the charged lepton is not identified. For a Higgs boson mass of 115 GeV, a limit is set at the 95% C.L. on the cross section multiplied by branching fraction for [p (p) over bar -> (Z/W)H](H -> b (b) over bar) that is a factor of 3.7 larger than the standard model value, consistent with the factor of 4.6 expected.
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| 47. |
- Abazov, V. M., et al.
(författare)
-
Search for ZH -> l(+)l(-) b(b)over-bar Production in 4.2 fb(-1) of p(p)over-bar Collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:25, s. 251801-
-
Tidskriftsartikel (refereegranskat)abstract
- We present a search for the standard model Higgs boson produced in association with a Z boson in 4: 2 fb(-1) of p (p) over bar collisions, collected with the D0 detector at the Fermilab Tevatron at root s = 1.96 TeV. Selected events contain one reconstructed Z -> e(+) e(-) or Z -> mu(+) mu(-) candidate and at least two jets, including at least one b-tagged jet. In the absence of an excess over the background expected from other standard model processes, limits on the ZH cross section multiplied by the branching ratios are set. The limit at M-H = 115 GeV is a factor of 5.9 larger than the standard model prediction.
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| 48. |
- Fitzmaurice, C., et al.
(författare)
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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015. A Systematic Analysis for the Global Burden of Disease Study
- 2017
-
Ingår i: Jama Oncology. - : American Medical Association (AMA). - 2374-2445 .- 2374-2437. ; 3:4, s. 524-548
-
Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Cancer is the second leading cause of death worldwide. Current estimates on the burden of cancer are needed for cancer control planning. OBJECTIVE To estimate mortality, incidence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 32 cancers in 195 countries and territories from 1990 to 2015. EVIDENCE REVIEW Cancer mortality was estimated using vital registration system data, cancer registry incidence data (transformed to mortality estimates using separately estimated mortality to incidence [MI] ratios), and verbal autopsy data. Cancer incidence was calculated by dividing mortality estimates through the modeled MI ratios. To calculate cancer prevalence, MI ratios were used to model survival. To calculate YLDs, prevalence estimates were multiplied by disability weights. The YLLs were estimated by multiplying age-specific cancer deaths by the reference life expectancy. DALYs were estimated as the sum of YLDs and YLLs. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Countries were categorized by SDI quintiles to summarize results. FINDINGS In 2015, there were 17.5 million cancer cases worldwide and 8.7 million deaths. Between 2005 and 2015, cancer cases increased by 33%, with population aging contributing 16%, population growth 13%, and changes in age-specific rates contributing 4%. For men, the most common cancer globallywas prostate cancer (1.6 million cases). Tracheal, bronchus, and lung cancerwas the leading cause of cancer deaths and DALYs in men (1.2 million deaths and 25.9 million DALYs). For women, the most common cancerwas breast cancer (2.4 million cases). Breast cancerwas also the leading cause of cancer deaths and DALYs forwomen (523000 deaths and 15.1 million DALYs). Overall, cancer caused 208.3 million DALYs worldwide in 2015 for both sexes combined. Between 2005 and 2015, age-standardized incidence rates for all cancers combined increased in 174 of 195 countries or territories. Age-standardized death rates (ASDRs) for all cancers combined decreased within that timeframe in 140 of 195 countries or territories. Countries with an increase in the ASDR due to all cancers were largely located on the African continent. Of all cancers, deaths between 2005 and 2015 decreased significantly for Hodgkin lymphoma (-6.1%[95% uncertainty interval (UI), -10.6% to -1.3%]). The number of deaths also decreased for esophageal cancer, stomach cancer, and chronic myeloid leukemia, although these results were not statistically significant. CONCLUSION AND RELEVANCE As part of the epidemiological transition, cancer incidence is expected to increase in the future, further straining limited health care resources. Appropriate allocation of resources for cancer prevention, early diagnosis, and curative and palliative care requires detailed knowledge of the local burden of cancer. The GBD 2015 study results demonstrate that progress is possible in the war against cancer. However, the major findings also highlight an unmet need for cancer prevention efforts, including tobacco control, vaccination, and the promotion of physical activity and a healthy diet.
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| 49. |
- Vos, T., et al.
(författare)
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Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
- 2017
-
Ingår i: Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 390:10100, s. 1211-1259
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Tidskriftsartikel (refereegranskat)abstract
- Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57.6 million (95% uncertainty interval [UI] 40.8-75.9 million [7.2%, 6.0-8.3]), 45.1 million (29.0-62.8 million [5.6%, 4.0-7.2]), 36.3 million (25.3-50.9 million [4.5%, 3.8-5.3]), 34.7 million (23.0-49.6 million [4.3%, 3.5-5.2]), and 34.1 million (23.5-46.0 million [4.2%, 3.2-5.3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2.7% (95% UI 2.3-3.1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10.4% (95% UI 9.0-11.8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862-11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018-19 228). Interpretation The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-todate information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. Copyright (C) The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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- Fullman, N., et al.
(författare)
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Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016
- 2018
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Ingår i: Lancet. - : Elsevier BV. - 0140-6736. ; 391:10136, s. 2236-2271
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Tidskriftsartikel (refereegranskat)abstract
- Background A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess personal health-care access and quality with the Healthcare Access and Quality (HAQ) Index for 195 countries and territories, as well as subnational locations in seven countries, from 1990 to 2016. Methods Drawing from established methods and updated estimates from GBD 2016, we used 32 causes from which death should not occur in the presence of effective care to approximate personal health-care access and quality by location and over time. To better isolate potential effects of personal health-care access and quality from underlying risk factor patterns, we risk-standardised cause-specific deaths due to non-cancers by location-year, replacing the local joint exposure of environmental and behavioural risks with the global level of exposure. Supported by the expansion of cancer registry data in GBD 2016, we used mortality-to-incidence ratios for cancers instead of risk-standardised death rates to provide a stronger signal of the effects of personal health care and access on cancer survival. We transformed each cause to a scale of 0-100, with 0 as the first percentile (worst) observed between 1990 and 2016, and 100 as the 99th percentile (best); we set these thresholds at the country level, and then applied them to subnational locations. We applied a principal components analysis to construct the HAQ Index using all scaled cause values, providing an overall score of 0-100 of personal health-care access and quality by location over time. We then compared HAQ Index levels and trends by quintiles on the Socio-demographic Index (SDI), a summary measure of overall development. As derived from the broader GBD study and other data sources, we examined relationships between national HAQ Index scores and potential correlates of performance, such as total health spending per capita. Findings In 2016, HAQ Index performance spanned from a high of 97.1 (95% UI 95.8-98.1) in Iceland, followed by 96.6 (94.9-97.9) in Norway and 96.1 (94.5-97.3) in the Netherlands, to values as low as 18.6 (13.1-24.4) in the Central African Republic, 19.0 (14.3-23.7) in Somalia, and 23.4 (20.2-26.8) in Guinea-Bissau. The pace of progress achieved between 1990 and 2016 varied, with markedly faster improvements occurring between 2000 and 2016 for many countries in sub-Saharan Africa and southeast Asia, whereas several countries in Latin America and elsewhere saw progress stagnate after experiencing considerable advances in the HAQ Index between 1990 and 2000. Striking subnational disparities emerged in personal health-care access and quality, with China and India having particularly large gaps between locations with the highest and lowest scores in 2016. In China, performance ranged from 91.5 (89.1-936) in Beijing to 48.0 (43.4-53.2) in Tibet (a 43.5-point difference), while India saw a 30.8-point disparity, from 64.8 (59.6-68.8) in Goa to 34.0 (30.3-38.1) in Assam. Japan recorded the smallest range in subnational HAQ performance in 2016 (a 4.8-point difference), whereas differences between subnational locations with the highest and lowest HAQ Index values were more than two times as high for the USA and three times as high for England. State-level gaps in the HAQ Index in Mexico somewhat narrowed from 1990 to 2016 (from a 20.9-point to 17.0-point difference), whereas in Brazil, disparities slightly increased across states during this time (a 17.2-point to 20.4-point difference). Performance on the HAQ Index showed strong linkages to overall development, with high and high-middle SDI countries generally having higher scores and faster gains for non-communicable diseases. Nonetheless, countries across the development spectrum saw substantial gains in some key health service areas from 2000 to 2016, most notably vaccine-preventable diseases. Overall, national performance on the HAQ Index was positively associated with higher levels of total health spending per capita, as well as health systems inputs, but these relationships were quite heterogeneous, particularly among low-to-middle SDI countries. Interpretation GBD 2016 provides a more detailed understanding of past success and current challenges in improving personal health-care access and quality worldwide. Despite substantial gains since 2000, many low-SDI and middle-SDI countries face considerable challenges unless heightened policy action and investments focus on advancing access to and quality of health care across key health services, especially non-communicable diseases. Stagnating or minimal improvements experienced by several low-middle to high-middle SDI countries could reflect the complexities of re-orienting both primary and secondary health-care services beyond the more limited foci of the Millennium Development Goals. Alongside initiatives to strengthen public health programmes, the pursuit of universal health coverage upon improving both access and quality worldwide, and thus requires adopting a more comprehensive view and subsequent provision of quality health care for all populations. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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