| 1. |
- Stevens, Kristen N, et al.
(författare)
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19p13.1 is a triple negative-specific breast cancer susceptibility locus
- 2012
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 72, s. 1795-
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Tidskriftsartikel (refereegranskat)abstract
- The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways.
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| 2. |
- Kirchhoff, Tomas, et al.
(författare)
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Breast cancer risk and 6q22.33 : combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
- 2012
-
Ingår i: PLOS ONE. - : Public library of science. - 1932-6203. ; 7:6
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
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| 3. |
- Ahlsson, Anders, et al.
(författare)
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Atrial function after epicardial microwave ablation in patients with atrial fibrillation
- 2008
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Ingår i: Scandinavian Cardiovascular Journal. - : Taylor & Francis. - 1401-7431 .- 1651-2006. ; 42:3, s. 192-201
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To study epicardial microwave ablation of concomitant atrial fibrillation and its effects on heart rhythm and atrial function during follow-up. DESIGN: The study included 20 open-heart surgery patients with concomitant atrial fibrillation. Transthoracic echocardiography with flow and tissue Doppler recordings was performed preoperatively and at 6 months postoperatively. Blood samples were obtained preoperatively and postoperatively for analysis of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and amino terminal precursor of brain natriuretic peptide (NT-proBNP). RESULTS: Fourteen of 19 patients (74%) were in sinus rhythm with no antiarrhythmic drugs at 12 months. All patients in sinus rhythm had preserved left and right atrial-filling waves through atrioventricular valves during atrial contraction. Tissue velocity echocardiography on patients in sinus rhythm showed preserved atrial wall velocities, atrial strain, and atrial strain rate. Levels of natriuretic peptides tended to decrease in patients with stable sinus rhythm at one year compared to patients in atrial fibrillation. CONCLUSIONS: Epicardial microwave ablation results in sinus rhythm in a majority of patients and seems to preserve atrial mechanical function
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| 4. |
- Cole, Michelle J., et al.
(författare)
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Ten years of external quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in Europe elucidate high reliability of data
- 2019
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Ingår i: BMC Infectious Diseases. - : BioMed Central. - 1471-2334. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Confidence in any diagnostic and antimicrobial susceptibility testing data is provided by appropriate and regular quality assurance (QA) procedures. In Europe, the European Gonococcal Antimicrobial Susceptibility Programme (Euro-GASP) has been monitoring the antimicrobial susceptibility in Neisseria gonorrhoeae since 2004. Euro-GASP includes an external quality assessment (EQA) scheme as an essential component for a quality-assured laboratory-based surveillance programme. Participation in the EQA scheme enables any problems with the performed antimicrobial susceptibility testing to be identified and addressed, feeds into the curricula of laboratory training organised by the Euro-GASP network, and assesses the capacity of individual laboratories to detect emerging new, rare and increasing antimicrobial resistance phenotypes. Participant performance in the Euro-GASP EQA scheme over a 10 year period (2007 to 2016, no EQA in 2013) was evaluated.METHODS: Antimicrobial susceptibility category and MIC results from the first 5 years (2007-2011) of the Euro-GASP EQA were compared with the latter 5 years (2012-2016). These time periods were selected to assess the impact of the 2012 European Union case definitions for the reporting of antimicrobial susceptibility.RESULTS: dilutions of the modal MIC, respectively. The most common method used was Etest on GC agar base. There was a shift to using breakpoints published by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) in the latter 5 years, however overall impact on the validity of results was limited, as the percentage categorical agreement and MIC concordance changed very little between the two five-year periods.CONCLUSIONS: The high level of comparability of results in this EQA scheme indicates that high quality data are produced by the Euro-GASP participants and gives confidence in susceptibility and resistance data generated by laboratories performing decentralised testing.
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| 5. |
- Gustavsson, Anders, et al.
(författare)
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Cost of disorders of the brain in Europe 2010.
- 2011
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Ingår i: European Neuropsychopharmacology. - Amsterdam : Elsevier BV. - 0924-977X .- 1873-7862. ; 21:10, s. 718-79
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The spectrum of disorders of the brain is large, covering hundreds of disorders that are listed in either the mental or neurological disorder chapters of the established international diagnostic classification systems. These disorders have a high prevalence as well as short- and long-term impairments and disabilities. Therefore they are an emotional, financial and social burden to the patients, their families and their social network. In a 2005 landmark study, we estimated for the first time the annual cost of 12 major groups of disorders of the brain in Europe and gave a conservative estimate of €386 billion for the year 2004. This estimate was limited in scope and conservative due to the lack of sufficiently comprehensive epidemiological and/or economic data on several important diagnostic groups. We are now in a position to substantially improve and revise the 2004 estimates. In the present report we cover 19 major groups of disorders, 7 more than previously, of an increased range of age groups and more cost items. We therefore present much improved cost estimates. Our revised estimates also now include the new EU member states, and hence a population of 514 million people.AIMS: To estimate the number of persons with defined disorders of the brain in Europe in 2010, the total cost per person related to each disease in terms of direct and indirect costs, and an estimate of the total cost per disorder and country.METHODS: The best available estimates of the prevalence and cost per person for 19 groups of disorders of the brain (covering well over 100 specific disorders) were identified via a systematic review of the published literature. Together with the twelve disorders included in 2004, the following range of mental and neurologic groups of disorders is covered: addictive disorders, affective disorders, anxiety disorders, brain tumor, childhood and adolescent disorders (developmental disorders), dementia, eating disorders, epilepsy, mental retardation, migraine, multiple sclerosis, neuromuscular disorders, Parkinson's disease, personality disorders, psychotic disorders, sleep disorders, somatoform disorders, stroke, and traumatic brain injury. Epidemiologic panels were charged to complete the literature review for each disorder in order to estimate the 12-month prevalence, and health economic panels were charged to estimate best cost-estimates. A cost model was developed to combine the epidemiologic and economic data and estimate the total cost of each disorder in each of 30 European countries (EU27+Iceland, Norway and Switzerland). The cost model was populated with national statistics from Eurostat to adjust all costs to 2010 values, converting all local currencies to Euro, imputing costs for countries where no data were available, and aggregating country estimates to purchasing power parity adjusted estimates for the total cost of disorders of the brain in Europe 2010.RESULTS: The total cost of disorders of the brain was estimated at €798 billion in 2010. Direct costs constitute the majority of costs (37% direct healthcare costs and 23% direct non-medical costs) whereas the remaining 40% were indirect costs associated with patients' production losses. On average, the estimated cost per person with a disorder of the brain in Europe ranged between €285 for headache and €30,000 for neuromuscular disorders. The European per capita cost of disorders of the brain was €1550 on average but varied by country. The cost (in billion €PPP 2010) of the disorders of the brain included in this study was as follows: addiction: €65.7; anxiety disorders: €74.4; brain tumor: €5.2; child/adolescent disorders: €21.3; dementia: €105.2; eating disorders: €0.8; epilepsy: €13.8; headache: €43.5; mental retardation: €43.3; mood disorders: €113.4; multiple sclerosis: €14.6; neuromuscular disorders: €7.7; Parkinson's disease: €13.9; personality disorders: €27.3; psychotic disorders: €93.9; sleep disorders: €35.4; somatoform disorder: €21.2; stroke: €64.1; traumatic brain injury: €33.0. It should be noted that the revised estimate of those disorders included in the previous 2004 report constituted €477 billion, by and large confirming our previous study results after considering the inflation and population increase since 2004. Further, our results were consistent with administrative data on the health care expenditure in Europe, and comparable to previous studies on the cost of specific disorders in Europe. Our estimates were lower than comparable estimates from the US.DISCUSSION: This study was based on the best currently available data in Europe and our model enabled extrapolation to countries where no data could be found. Still, the scarcity of data is an important source of uncertainty in our estimates and may imply over- or underestimations in some disorders and countries. Even though this review included many disorders, diagnoses, age groups and cost items that were omitted in 2004, there are still remaining disorders that could not be included due to limitations in the available data. We therefore consider our estimate of the total cost of the disorders of the brain in Europe to be conservative. In terms of the health economic burden outlined in this report, disorders of the brain likely constitute the number one economic challenge for European health care, now and in the future. Data presented in this report should be considered by all stakeholder groups, including policy makers, industry and patient advocacy groups, to reconsider the current science, research and public health agenda and define a coordinated plan of action of various levels to address the associated challenges.RECOMMENDATIONS: Political action is required in light of the present high cost of disorders of the brain. Funding of brain research must be increased; care for patients with brain disorders as well as teaching at medical schools and other health related educations must be quantitatively and qualitatively improved, including psychological treatments. The current move of the pharmaceutical industry away from brain related indications must be halted and reversed. Continued research into the cost of the many disorders not included in the present study is warranted. It is essential that not only the EU but also the national governments forcefully support these initiatives.
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| 6. |
- Alam, Moudud, et al.
(författare)
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Utvärdering av det arbetsmarknadspolitiska projektet "Volvo Cars och dess underleverantörer"
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport är en utvärdering av det arbetsmarknadspolitiska projektet "Volvo Cars och dess underleverantörer", som har genomförts av Arbetsförmedlingen i samarbete med Skolverket och Svenska ESF-rådet. Den 5 juni 2009 ansökte Sveriges regering om medel hos den Europeiska globaliseringsfonen (EGF)2 för att kunna erbjuda åtgärder för personer som blivit uppsagda från Volvo Cars AB och dess underleverantörer. Syftet med projektet var att kunna erbjuda de som blivit uppsagda kompetensutveckling, nya yrkeskunskaper och möjlighet att etablera egna företag.På operativ nivå drevs projektet i samverkan mellan Arbetsförmedlingen och den kom-munala yrkesvuxenutbildningen ("Yrkesvux"). Yrkesvux i Göteborgs kommun fick i upp-drag av Skolverket att samordna den del av verksamheten som berörde kommunal yr-kesvuxenutbildning. Projektet startade 1 januari 2010 och avslutades 31 maj 2011. Enligt kommissionens beslut fick medel även användas retroaktivt för insatser som hade givits till de uppsagda i form av olika arbetsmarknadsutbildningar, det s.k. snabbspåret, under 2009 innan projektet hade startat.Av nästan 5 000 individer i målgruppen som registrerade sig vid Arbetsförmedlingen del-tog knappt en fjärdedel i projektets insatser (exkl. vägledning). Av dessa gick 55 procent i aktiviteter enbart genom Arbetsförmedlingen, 37 procent enbart genom Yrkesvux och åtta procent genom både Arbetsförmedlingen och Yrkesvux. De vanligaste förekommande utbildningsinriktningarna var industri och bygg, fordonsindustri, transport och magasine-ring, omvårdnad och handel.
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| 7. |
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| 8. |
- Andersen, Torben, et al.
(författare)
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An Integrated Model of the European Extremely Large Telescope
- 2008
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Ingår i: MODELLING, SYSTEMS ENGINEERING, AND PROJECT MANAGEMENT FOR ASTRONOMY III. - : SPIE. - 1996-756X .- 0277-786X. ; 7017, s. 216-227
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Konferensbidrag (refereegranskat)abstract
- Integrated models including optics, structures, control systems, and disturbances are important design tools for Extremely Large Telescopes (ELTs). An integrated model has keen formulated for the European ELT and it includes telescope structure, main servos, primary mirror segment control system, wind, optics, wavefront sensor, deformable mirror, and an AO reconstructor and controller. There are three model phases: Initialization, execution of a solver to determine time responses, and post-processing. In near future, the model will be applied for performance studies and design trade-offs for the European ELT.
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| 9. |
- Angelova, Milena, et al.
(författare)
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An Expertise Recommender System based on Data from an Institutional Repository (DiVA)
- 2019
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Ingår i: Connecting the Knowledge Common from Projects to sustainable Infrastructure. - : OpenEdition Press. - 9791036538018 - 9791036538025 ; , s. 135-149
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Bokkapitel (refereegranskat)abstract
- Finding experts in academics is an important practical problem, e.g. recruiting reviewersfor reviewing conference, journal or project submissions, partner matching for researchproposals, finding relevant M. Sc. or Ph. D. supervisors etc. In this work, we discuss anexpertise recommender system that is built on data extracted from the Blekinge Instituteof Technology (BTH) instance of the institutional repository system DiVA (DigitalScientific Archive). DiVA is a publication and archiving platform for research publicationsand student essays used by 46 publicly funded universities and authorities in Sweden andthe rest of the Nordic countries (www.diva-portal.org). The DiVA classification system isbased on the Swedish Higher Education Authority (UKÄ) and the Statistic Sweden's (SCB)three levels classification system. Using the classification terms associated with studentM. Sc. and B. Sc. theses published in the DiVA platform, we have developed a prototypesystem which can be used to identify and recommend subject thesis supervisors in academy.
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| 10. |
- Angelova, Milena, et al.
(författare)
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An Expertise Recommender SystemBased on Data from an Institutional Repository (DiVA)
- 2018
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Ingår i: Proceedings of the 22nd edition of the International Conference on ELectronic PUBlishing. - : OpenEdition Press.
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Konferensbidrag (refereegranskat)abstract
- Finding experts in academics is an important practical problem, e.g. recruiting reviewersfor reviewing conference, journal or project submissions, partner matching for researchproposals, finding relevant M. Sc. or Ph. D. supervisors etc. In this work, we discuss anexpertise recommender system that is built on data extracted from the Blekinge Instituteof Technology (BTH) instance of the institutional repository system DiVA (DigitalScientific Archive). DiVA is a publication and archiving platform for research publicationsand student essays used by 46 publicly funded universities and authorities in Sweden andthe rest of the Nordic countries (www.diva-portal.org). The DiVA classification system isbased on the Swedish Higher Education Authority (UKÄ) and the Statistic Sweden's (SCB)three levels classification system. Using the classification terms associated with studentM. Sc. and B. Sc. theses published in the DiVA platform, we have developed a prototypesystem which can be used to identify and recommend subject thesis supervisors inacademy.
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| 11. |
- Anthony, David B., et al.
(författare)
-
STRUCTURAL SUPERCAPACITOR COMPOSITE TECHNOLOGY DEMONSTRATOR
- 2022
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Ingår i: ECCM 2022 - Proceedings of the 20th European Conference on Composite Materials: Composites Meet Sustainability. ; 5, s. 253-259
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Konferensbidrag (refereegranskat)abstract
- Structural power composites, a class of multifunctional materials, have significant potential to facilitate lightweighting and accelerate widespread electrification in sustainable transportation. In civil aircraft, a bank of supercapacitors can provide power to open the doors in an emergency. Structural power composite fuselage components near the doors could provide this power and eliminate the mass and volume needed for the supercapacitors. To demonstrate this concept, we designed and manufactured a multifunctional component representative of a fuselage rib, which powered the opening and closing of a desktop scale composite aircraft door. This paper provides information about structural supercapacitor technology demonstrators, discusses the fabrication of this demonstrator and concludes by providing an insight into the future challenges that need to be addressed to realise structural power composite components.
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| 12. |
- Ardeberg, Arne, et al.
(författare)
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Clusters as probes of distance, evolution, and chemistry of galaxies
- 2003
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Ingår i: Proceedings of the SPIE - The International Society for Optical Engineering. - : SPIE. - 1996-756X .- 0277-786X. ; 5382:1, s. 47-56
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Konferensbidrag (refereegranskat)abstract
- Stellar clusters are highly useful as tools for determination of distances, ages and abundances of heavy elements of galaxies, also at larger distances. Their utility for these purposes has, so far, been severely limited, mainly due to image crowding. The introduction of Extremely Large Telescopes (ELTs) with full adaptive optics (AO) and near diffraction limited performance should imply a drastic improvement concerning the usefulness of clusters and the limiting distances of high quality data. We have made a study of stellar clusters as probes of distance, evolution and chemistry of galaxies at distances from one to twenty Mpc. From data on the Stromgren uvby system, partly from direct measurements taken from the literature, we have synthesized test clusters, one open and one globular, as well as galactic backgrounds. The clusters have been embedded in the backgrounds and located at distances between one and twenty Mpc. Here, vby data have been measured, reduced and analyzed. Color-magnitude diagrams (CMDs), metallicity diagrams (MDs) and luminosity functions (LFs) have been constructed. They have been evaluated absolutely and compared to the corresponding template data. We conclude that with a 50 m AO ELT, for open as well as globular clusters, MDs are of high quality for clusters out to and beyond 5 Mpc and useful out to 10 Mpc. CMDs are of very high quality well beyond 5 Mpc. They are of high scientific value out to and beyond 10 Mpc and valuable for clusters even out to 20 Mpc. LFs are highly informative well beyond 10 Mpc and still rather valuable at 20 Mpc. With sufficient measurement data available, LFs are useful for clusters in galaxies even beyond 20 Mpc
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| 13. |
- Ardeberg, Arne, et al.
(författare)
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ELTs, adaptive optics, and wavelengths
- 2008
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Ingår i: Proceedings of SPIE, the International Society for Optical Engineering. ; 6986, s. 1-698608
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Konferensbidrag (refereegranskat)
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| 14. |
- Ardeberg, Arne, et al.
(författare)
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ELTs, adaptive optics and wavelengths - art. no. 698608
- 2008
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Ingår i: Extremely Large Telescopes: Which Wavelengths? Retirement Symposium for Arne Ardeberg. - : SPIE. - 1996-756X .- 0277-786X. ; 6986, s. 98608-98608
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Konferensbidrag (refereegranskat)abstract
- A number of Extremely Large Telescopes for visual-infrared and adjacent wavelengths are in various degrees of progress. All have primary mirrors with equivalent diameters larger than 20 m and are intended for operation with adaptive optics systems. We discuss several ELT observing parameters as functions of wavelength. Stellar energy distributions and atomic line spectra are inspected as are the transmission of the Earth's atmosphere, the emissivity of the sky and telescope and instruments as well as detector sensitivity, resolution and signal-to-noise ratio. The spatial resolution depending on the size of the diffraction limited adaptive optics point spread function is discussed. We have evaluated the ELT efficiency in terms of Johnson V to N band photometry, simulating diffraction-limited ELT images of a stellar field at 4 Mpc and 4 kpc, respectively. We conclude that the information content at shorter wavelengths is of dominant nature and that there is every reason to do the utmost to include shorter wavelengths in the AO regime. We propose to adopt a short-wave length goal of 1 000 nm for first light AO with later updates reaching down to visual wavelengths.
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| 15. |
- Ardeberg, Ame, et al.
(författare)
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ELTs, AO wavelengths and science output
- 2008
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Ingår i: GROUND-BASED AND AIRBORNE TELESCOPES II, PTS 1-3. - 0277-786X .- 1996-756X. ; 7012, s. 121-121
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Konferensbidrag (refereegranskat)abstract
- A study is presented of the impact on science data from extremely large telescopes of a transformation of wavelength base for optimization of actuator architecture from 2 200 to 1250 nm. From the optical path difference (OPD) data for Euro50, we transform to E-ELT OPDs. We compute the corresponding power spectrum, in which we simulate a higher actuator density via high-pass filtering to convert from K to J band actuator-pitch optimization. From the modified power spectrum we derive the correspondingly modified OPDs, PSFs and Strehl ratios. A massive improvement is demonstrated resulting from converting from AO@K to AO@J. This result is followed up by model-based E-ELT imaging in a field in a galactic disc at a distance of 4 Mpc. The improvements in image quality, background and limiting magnitude are very large as are the increases in photometric precision derived from the field imaging. Further, the great science benefit and large opportunities provided by partial AO is demonstrated. In conclusion, while admittedly challenging, pushing AO optimization to wavelengths as short as possible is of prime concern for the science output of ELTs.
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| 16. |
- Ardeberg, Arne, et al.
(författare)
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Evolution of distant galaxies from cluster photometry: a program for a 50-m ELT
- 2004
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Ingår i: Proceedings of the SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 5489:1, s. 72-83
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Konferensbidrag (refereegranskat)abstract
- The formation, shaping and evolution of galaxies are processes of high interest but poorly known. This is true also for our closest galactic neighbours. Of key importance is a representative sample of all major types of galaxies with solid evolutionary parameters. Stellar clusters are excellent probes of galactic evolution, albeit so far useful at smaller distances only, mainly due to the limiting effects of image crowding. With extremely large telescopes (ELTs) with full adaptive optics (AO) and near diffraction limited performance, the effects of image crowding will be drastically reduced. Thus, the excellence of clusters of stars as evolutionary probes can be extended out to cosmological distances. We have studied this extension. With data on the Str
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| 17. |
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| 18. |
- Ardeberg, Arne, et al.
(författare)
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On the history of star formation in the bar of the Large Magellanic Cloud
- 1997
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Ingår i: ASTRONOMY AND ASTROPHYSICS. - : SPRINGER VERLAG. - 0004-6361. ; 322:2, s. L13-L16
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Tidskriftsartikel (refereegranskat)abstract
- With the HST PC and uvby photometry, we investigate evolutionary signatures in a field in the centre of the LMC Bar. Field stars close to the turn off point in the HR diagram are used for a study of ages and evolution of the stellar popu lations dominatin
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| 19. |
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| 20. |
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| 21. |
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| 22. |
- Austin, James D, et al.
(författare)
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Permanent Genetic Resources added to Molecular Ecology Resources Database 1 February 2011-31 March 2011.
- 2011
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Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 11:4, s. 757-758
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Tidskriftsartikel (refereegranskat)abstract
- This article documents the addition of 111 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Acipenser oxyrinchus desotoi, Anopheles nuneztovari sensu lato, Asellus aquaticus, Calopteryx splendens, Calopteryx virgo, Centaurea aspera, Centaurea seridis, Chilina dombeyana, Proctoeces cf. lintoni and Pyrenophora teres f. teres.
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| 23. |
- Bergman, Jakob, et al.
(författare)
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Är SD Sveriges största parti?
- 2016
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Ingår i: Symposium i anvendt statistik. - 9788750122104 ; , s. 95-99
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Den 20 augusti 2015 hävdade dagstidningen Metro att Sverigedemokraterna var Sveriges största parti. Detta baserade man på att partiet blivit det största i en opinions-undersökning av företaget YouGov. Men hur kan man testa påståendet att en specifik andel är den största? Vi tar vår utgångspunkt i andelarnas speciella parameterrum simplex och dess inbyggda restriktioner. Vi visar hur man kan konstruera ett test för att avgöra om en specifik andel är störst baserat på en likelihoodkvotansats, där vi utnyttjar en isometrisk logkvotstransformation för att underlätta de numeriska beräkningarna. Eftersom man vid denna typ av problem typiskt enbart har en enda observation av de relativa partipreferenser, diskuterar vi teststorhetens fördelning. Vi illustrerar våra resonemang med data från den ovan nämnda undersökningen av YouGov.
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| 24. |
- Bigagli, Lorenzo, et al.
(författare)
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Infrastructure and technology challenges
- 2014
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Rapport (refereegranskat)abstract
- In this deliverable, we report on our work on infrastructural and technological barriers to Open Access and preservation of research data as identified by key stakeholder groups. Through a mix of qualitative, quantitative and document review methods, we identified five key barriers to successfully implementing Open Access to research data in Europe: data heterogeneity and issues of standardisation; accessibility and discoverability issues; data preservation and curation; data quality and assessability; and data security. We explore these issues in detail and present existing good practice, and technical and infrastructural solutions used to mitigate such barriers. This work was conducted within the EU FP7 funded project RECODE, which focuses on developing policy recommendations for Open Access to Research Data in Europe. In particular, this work is coordinated by RECODE Work Package 2 (WP2), Infrastructure and technology.
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| 25. |
- Carlsson, Fredrik, 1968, et al.
(författare)
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Are Vietnamese Farmers Concerned with their Relative Position in Society?
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper examines the attitude towards relative position or status among rural households in Vietnam. On average, the respondents show weaker preferences for relative position than in comparable studies in Western countries. Possible explanations are the emphasis on the importance of equality and that villagers are very concerned with how the local community perceives their actions. We also investigate what influences the concern for relative position and find, among other things, that if anyone from the household is a member of the Peoples Committee then the respondent is more concerned with the relative position.
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| 26. |
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| 27. |
- Carlstedt, David, 1984, et al.
(författare)
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Conceptual design framework for laminated structural battery composites
- 2020
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Ingår i: ECCM 2018 - 18th European Conference on Composite Materials. - : Applied Mechanics Laboratory.
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Konferensbidrag (refereegranskat)abstract
- The structural battery composite is a class of composite materials with ability to provide mechanical integrity in a structural system while simultaneously store electrical energy (i.e. work as a battery). In this paper a framework to estimate the mechanical and electrical performance of laminated structural battery composites is proposed. The mechanical performance of the battery composite laminate is assessed by estimating the in-plane elastic properties of the laminate using Classical Laminate Theory. The electrical performance is assessed estimating the specific capacity and energy density of the component. The developed framework is applied on an A4 sized structural battery composite demonstrator, as part of the Clean Sky 2 project SORCERER [1] to demonstrate the capabilities of the framework. The design process for the demonstrator is presented and mechanical and electrical performance metrics are estimated for three laminate configurations, one promoting structural performance, one promoting electrical performance and one intermediate. As the material provides both load carrying and electrical energy storage capabilities, the laminate configuration can be alternated to provide suitable performance based on the purpose of the component.
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| 28. |
- Cortese, Federico, et al.
(författare)
-
GENERALIZED INFORMATION CRITERIA FOR SPARSE STATISTICAL JUMP MODELS
- 2023
-
Ingår i: Symposium i anvendt statistik 2023. - 9788798937036 ; , s. 68-78
-
Bokkapitel (refereegranskat)abstract
- We extend the generalized information criteria for high-dimensional penalizedmodels to sparse statistical jump models, a new class of statistically robust and computationally efficient alternatives to hidden Markov models. In a simulation study, we demonstrate that the new generalized information criteria selects the correct hyperparameters with high probability. Finally, providing an empirical application, we infer the key features that drive the return dynamics of the largest cryptocurrencies. We find that a four-state model best describes the dynamics of cryptocurrency returns. The states have natural market-based interpretations as they correspond to bull, bull-neutral, bear-neutral, and bear market regimes, respectively.
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| 29. |
- Davis, Michael, et al.
(författare)
-
BETEXT : Cross Institutional Cooperation in the Digitalization of Cultural Heritage Documents in XML
- 2002
-
Konferensbidrag (refereegranskat)abstract
- The following describes a digitalization and on-line publication project, led by members of Blekinge Institute of Technology, located in the south of Sweden. The project aimed to create the foundation for a regional network of small cultural institutions that would develop, support and utilize on-line full text archives in the service of tourism, marketing and education. Its pilot project, The Chapman Archive, involved the digitalization, encoding with the TEI DTD in XML and web-publication of two rare 18th century texts of both regional and international importance.
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| 30. |
- Dickstein, Kenneth, et al.
(författare)
-
CRT Survey II : a European Society of Cardiology survey of cardiac resynchronisation therapy in 11 088 patients-who is doing what to whom and how?
- 2018
-
Ingår i: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 20:6, s. 1039-1051
-
Tidskriftsartikel (refereegranskat)abstract
- Background Cardiac resynchronisation therapy (CRT) reduces morbidity and mortality in appropriately selected patients with heart failure and is strongly recommended for such patients by guidelines. A European Society of Cardiology (ESC) CRT survey conducted in 2008-2009 showed considerable variation in guideline adherence and large individual, national and regional differences in patient selection, implantation practice and follow-up. Accordingly, two ESC associations, the European Heart Rhythm Association and the Heart Failure Association, designed a second prospective survey to describe contemporary clinical practice regarding CRT. Methods and results A survey of the clinical practice of CRT-P and CRT-D implantation was conducted from October 2015 to December 2016 in 42 ESC member countries. Implanting centres provided information about their hospital and CRT service and were asked to complete a web-based case report form collecting information on patient characteristics, investigations, implantation procedures and complications during the index hospitalisation. The 11 088 patients enrolled represented 11% of the total number of expected implantations in participating countries during the survey period; 32% of patients were aged >= 75 years, 28% of procedures were upgrades from a permanent pacemaker or implantable cardioverter-defibrillator and 30% were CRT-P rather than CRT-D. Most patients (88%) had a QRS duration >= 130 ms, 73% had left bundle branch block and 26% were in atrial fibrillation at the time of implantation. Large geographical variations in clinical practice were observed. Conclusion CRT Survey II provides a valuable source of information on contemporary clinical practice with respect to CRT implantation in a large sample of ESC member states. The survey permits assessment of guideline adherence and demonstrates variations in patient selection, management, implantation procedure and follow-up strategy.
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| 31. |
- Enbom, Malin, et al.
(författare)
-
Antibodies to human herpesvirus 8 latent and lytic antigens in blood donors and potential high-risk groups in Sweden : variable frequencies found in a multicenter serological study
- 2000
-
Ingår i: Journal of Medical Virology. - 0146-6615 .- 1096-9071. ; 62:4, s. 498-504
-
Tidskriftsartikel (refereegranskat)abstract
- Human herpesvirus 8 (HHV-8) is a herpesvirus associated with Kaposi's sarcoma (KS). An immunofluorescence assay was used for detection of IgG, IgM, and IgA antibodies against lytic and latent HHV-8 antigens to analyse samples from KS patients (n = 8), healthy blood donors (n = 162), individuals with a high risk sexual behaviour (n = 114), and bone marrow transplant patients (with high risk for bloodborne infections) (n = 34) in Sweden. Of the KS patients, 88% had IgG antibodies to both lytic and latent antigens by immunofluorescence. In all other groups, antilatent antibodies were rare (0-2.6%). IgG antibodies to the lytic antigens were found, by immunofluorescence, in 20% of the blood donors, 31% of the high risk patients, and in 24 and 29% of the bone marrow transplant patients (pre- and post-transplant samples, respectively). For verification of the specificity of the anti-lytic antibodies, 170 of the samples were also tested blindly at different laboratories world-wide with five other assays shown previously to detect HHV-8 antibodies in most KS patients. By using two recombinant HHV-8 proteins (ORF65/vp17 and K8.1/gp 35-37) in ELISA, a whole-virion ELISA and two immunofluorescence assays confirmation of the reactivity against lytic viral antigens was sought. The comparison of the different methods suggested the K8.1 ELISA to be highly specific and also showed a good agreement between two of the immunofluorescence assays. However, generally there was a poor correlation for positive results, indicating the need of further methodological development.
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| 32. |
- Eriksson, Jörgen, et al.
(författare)
-
Parallellpublicering av konferensartiklar : principer, tillämpningar och tillgänglighet i svenska publiceringsdatabaser
- 2012
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektets huvudsyfte har varit att undersöka kvalitetsgranskade konferensartiklars tillgänglighet samt konferensers OA- och publiceringspolicies för att på så sätt klarlägga olika aspekter vad det gäller parallellpublicering i svenska publiceringsdatabaser. För ändamålet har projektdeltagarna undersökt ett urval konferenser och konferensartiklar via sina publiceringsdatabaser under ett specifikt tidsintervall och beskrivit dem utifrån ett gemensamt schema.Undersökningen har visat att publiceringsdatabaserna fyller en viktig funktion för att synliggöra konferenspublikationer. Vi har funnit att minst ca. 50 % av konferensartiklarna kan publiceras som post-prints i våra publiceringsdatabaser. Därför är det av stor vikt att fortsätta arbetet med att utnyttja de lokala publiceringsdatabaserna som publiceringskanal och att inte bara använda dem som ett verktyg för parallellpublicering och primärpublicerat material, som avhandlingar och rapporter, utan även som en källa framförallt för konferensartiklar ”utan hem”, som vi nu vet utgör en stor del av vårt undersökningsmaterial (ca. 15 %).Mellan 20-25 % av de undersökta artiklarna fanns i något slags öppet OA-arkiv; ca. hälften av dessa fanns i någon av projektdeltagarnas egen publiceringsdatabas. Detta talar för att den egna publiceringsdatabasen är en viktig faktor för öppen tillgänglighet.Ca. 10% av konferenserna i studien hade en uttrycklig OA-policy eller gav uttryck för en sådan genom att öppet tillgängliggöra konferensartiklar på sina konferenssajter. Ett stort problem när det gäller parallellpublicering av konferensartiklar är just bristen på information om OA-policy.Konferenspubliceringslandskapet är komplicerat och parallellpubliceringen av dokument härifrån är mycket tidskrävande. Vi skulle framför allt önska en liknande policy-resurs som SHERPA/RoMEO för konferenser. Men för närvarande finns inget annat alternativ än att lusläsa konferensernas upphovsrättsinformation till författarna och av denna försöka dra slutsatser om ev. parallellpublicering.För att underlätta framtida hantering och klassificering av konferensartiklar i svenska publicerings-databaser, framför allt med tanke på ev. framtida nationella bibliometriska analyser via SwePub, föreslås ett antal rekommendationer.
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| 33. |
- Faria, Daniel, et al.
(författare)
-
The usage of Stromgren photometry in studies of local group dwarf spheroidal galaxies - Application to Draco: a new catalogue of Draco members and a study of the metallicity distribution function and radial gradients
- 2007
-
Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 465:2, s. 28-357
-
Tidskriftsartikel (refereegranskat)abstract
- Aims. In this paper we demonstrate how Stromgren uvby photometry can be efficiently used to: 1. identify red giant branch stars that are members in a dwarf spheroidal galaxy; 2. derive age-independent metallicities for the same stars and quantify the associated errors. Methods. Stromgren uvby photometry in a 11 x 22 arcmin field centered on the Draco dwarf spheroidal galaxy was obtained using the Isaac Newton Telescope on La Palma. Members of the Draco dSph galaxy were identified using the surface gravity sensitive c(1) index which discriminates between red giant and dwarf stars. Thus enabling us to distinguish the (red giant branch) members of the dwarf spheroidal galaxy from the foreground dwarf stars in our galaxy. The method is evaluated through a comparison of our membership list with membership classifications in the literature based on radial velocities and proper motions. The metallicity sensitive m(1) index was used to derive individual and age-independent metallicities for the members of the Draco dSph galaxy. The derived metallicities are compared to studies based on high resolution spectroscopy and the agreement is found to be very good. Results. We present metallicities for 169 members of the red giant branch in the Draco dwarf spheroidal galaxy (the largest sample to date). The metallicity distribution function for the Draco dSph galaxy shows a mean [Fe/H] = -1.74 dex with a spread of 0.24 dex. The correlation between metallicity and colour for the stars on the red giant branch is consistent with a dominant old, and coeval population. There is a possible spatial population gradient over the field with the most metal-rich stars being more centrally concentrated than the metal-poor stars.
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| 34. |
- Furtado, Carolina, et al.
(författare)
-
Effects of ply thickness and architecture on the strength of composite sub-structures
- 2021
-
Ingår i: Composite Structures. - : Elsevier BV. - 0263-8223. ; 256
-
Tidskriftsartikel (refereegranskat)abstract
- This work presents an experimental study on the effect of: ply thickness; ply-level hybridization; and type of ply architecture on the damage mechanisms that dominate failure and strength of multidirectional laminates. Nine effectively equivalent 0°dominated multidirectional laminates made from unidirectional carbon fibre tapes (UD), non-crimp fabrics (NCF) and spread-tow fabrics (STF) with thickness ranging from 67 μm to 268 μm are defined and tested under plain strength tension and compression, open-hole tension and compression, filled-hole compression and tension-bearing. An overall improvement of the strengths with the decrease of ply thickness is observed for the UD and NCF laminates, but nearly no effect of ply thickness is detected for STF laminates. Ply-level hybridization, where thin off-axis plies are combined with thicker grade 0°plies contributes to the improvement of the laminate response, especially when thicker 0°plies are used. However, hybrid-ply laminates are more sensitive to the loading direction and are, therefore, only suitable in structures where highly oriented loadings are expected. Fabric-based laminates do not show especial susceptibility to early failure compared to UD laminates. Their use can, therefore, be an economical solution that does not compromise the structural response, ensuring the weight benefits of composite materials at lower processing costs.
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| 35. |
- Furtado, C., et al.
(författare)
-
Is there a ply thickness effect on the mode I intralaminar fracture toughness of composite laminates?
- 2020
-
Ingår i: Theoretical and Applied Fracture Mechanics. - : Elsevier BV. - 0167-8442. ; 107
-
Tidskriftsartikel (refereegranskat)abstract
- The apparent crack resistance curves associated with longitudinal tensile failure of carbon fibre reinforced epoxy composite systems with ply thicknesses of 0.075 mm, 0.134 mm and 0.268 mm are determined experimentally from the size effect law of geometrically similar double edge notch tension cross-ply specimens. An increase in notched strength as a function of the ply thickness and a corresponding increase of the measured intralaminar fracture toughness is observed. This increase is shown to be a consequence of the appearance of split cracks in the thicker 0 degrees plies in the vicinity of the notches. The numerical models developed demonstrate that if the notch blunting mechanisms are properly represented, the laminate strength is well predicted for a constant value of the ply intralaminar fracture toughness. This supports the hypothesis that these mechanisms are responsible for the higher strength of the thicker plies, and that the intralaminar fracture toughness of the 0 degrees plies should not be scaled with the ply thickness.
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| 36. |
- Furuland, Hans, 1956-
(författare)
-
Effects of Hemoglobin Normalization with Epoetin in Chronic Kidney Disease
- 2005
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Anemia is common in patients with chronic kidney disease (CDK), contributes to reduced Quality of Life (QoL) and is associated with cardiovascular disease, morbidity and mortality. Epoetin raises hemoglobin (Hb) and increases QoL and physical exercise capacity. Because of concerns about safety and economics, current anemia treatment with epoetin aims to achieve subnormal Hb (110-120 g/l). Normalization of Hb may be of additional benefit regarding QoL and cardiovascular effects. The present study examines the effects of Hb normalization with epoetin on safety variables, QoL, graft function after kidney transplantation, dialysis adequacy, hemorheology, hemodynamics and cardiac autonomic function in CKD patients. In a randomized, multicenter study comprising 416 pre-dialysis and dialysis patients no difference was observed between patients treated to a normal or a subnormal Hb level on mortality, thrombovascular events, serious adverse events, vascular access thrombosis and residual renal function. QoL was enhanced in a subgroup of hemodialysis patients. Pretransplant epoetin treatment directed toward normal Hb levels did not result in worse graft function during 6 postoperative months. Dialysis adequacy was reduced in a subgroup of hemodialysis patients after normalization of Hb. The blood flow properties of pre-dialysis patients were altered. The hemorheological investigation demonstrated that Hb normalization caused a parallel increase in hematocrit and blood viscosity without other hemorheological changes. While the total peripheral resistance index increased, the cardiac index (CI) decreased. In a separate study cardiac autonomic function, measured by heart rate variability, was decreased in pre-dialysis patients. It was improved, but not fully normalized, by Hb normalization. On the basis of this study, Hb normalization with epoetin appears to be safe and increases QoL in hemodialysis patients though may result in lower dialysis adequacy and increased blood pressure. A reduction in CI and improved cardiac autonomic function indicate a positive effect on cardiovascular function.
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| 37. |
- Greenhalgh, Emile S., et al.
(författare)
-
En route to “massless energy” with structural power composites
- 2019
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Structural power composites are structural composites with the additional functionality of storing electrical energy. This paper provides an overview of the recent developments in structural batteries and structural supercapacitors, and an industrial perspective on the future challenges for their introduction. Popular science paper in: JEC Composites Magazine / Special Issue Smart Cities / November 2019
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| 38. |
- Gustavsson, Anders, et al.
(författare)
-
Corrigendum to “Cost of disorders of the brain in Europe 2010” [Eur. Neuropsychopharmacol. 21 (2011) 718–779]
- 2012
-
Ingår i: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 22:3, s. 237-238
-
Tidskriftsartikel (refereegranskat)abstract
- The spectrum of disorders of the brain is large, covering hundreds of disorders that are listed in either the mental or neurological disorder chapters of the established international diagnostic classification systems. These disorders have a high prevalence as well as short- and long-term impairments and disabilities. Therefore they are an emotional, financial and social burden to the patients, their families and their social network. In a 2005 landmark study, we estimated for the first time the annual cost of 12 major groups of disorders of the brain in Europe and gave a conservative estimate of €386 billion for the year 2004. This estimate was limited in scope and conservative due to the lack of sufficiently comprehensive epidemiological and/or economic data on several important diagnostic groups. We are now in a position to substantially improve and revise the 2004 estimates. In the present report we cover 19 major groups of disorders, 7 more than previously, of an increased range of age groups and more cost items. We therefore present much improved cost estimates. Our revised estimates also now include the new EU member states, and hence a population of 514 million people.
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| 39. |
- Hedin, Katarina, et al.
(författare)
-
Initial symptoms and three months follow-up after acute COVID-19 in outpatients : An international prospective cohort study
- 2023
-
Ingår i: European Journal of General Practice. - : Informa UK Limited. - 1381-4788 .- 1751-1402. ; 29:2
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Most studies on long-term follow-up of patients with COVID-19 focused on hospitalised patients. No prospective study with structured follow-up has been performed in non-hospitalised patients with COVID-19. Objectives: To assess long-COVID and post-COVID (WHO definition: symptomatic at least 12 weeks), describe lingering symptoms, their impact on daily activities, and general practice visits and explore risk factors for symptom duration in outpatients. Methods: A prospective study of adult outpatients with confirmed SARS-CoV-2 infection and symptoms consistent with COVID-19 in 11 European countries, recruited during 2020 and 2021 from primary care and the community. Structured follow-up by phone interviews (symptom rating, symptom impact on daily activities and general practice visits) was performed at weeks 2, 4, 8, and 12 by study personnel. Data was analysed descriptively by using correlation matrixes and Cox regression. Results: Of 270 enrolled patients, 52% developed long-COVID and 32% post-COVID-syndrome. When only considering the presence of moderate or (very) severe symptoms at weeks 8 and 12, these percentages were 28% and 18%, respectively. Fatigue was the most often reported symptom during follow-up. The impact of lingering symptoms was most evident in sports and household activities. About half (53%) had at least one general practice contact during follow-up. Obese patients took twice as long to return to usual health (HR: 0.5, 95%CI: 0.3–0.8); no other risk profile could predict lingering symptoms. Conclusion: Long-COVID and post-COVID are also common in outpatients. In 32%, it takes more than 12 weeks to return to usual health.
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| 40. |
- Hernández, Francisca, et al.
(författare)
-
Xml for Libraries, Archives, and Museums : The Project Covax
- 2003
-
Ingår i: Applied Artificial Intelligence. - : Taylor & Francis. - 0883-9514 .- 1087-6545. ; 17:8-9, s. 797-816
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of COVAX is to analyze and create the technical solutions required to provide access through the Internet to homogeneously-encoded document descriptions of archive, library, and museum collections based in the application of XML. This paper describes the development of the project, and the main achievements in building an information system of distributed XML databases containing document descriptions from libraries, archives, and museums emphasizing the conversion processes needed to transform legacy data to an XML environment.
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| 41. |
- Husby, Simon, et al.
(författare)
-
miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator
- 2015
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 125:17, s. 2669-2677
-
Tidskriftsartikel (refereegranskat)abstract
- Recent studies show that mantle cell lymphoma (MCL) express aberrant microRNA (miRNA) profiles; however, the clinical effect of miRNA expression has not previously been examined and validated in large prospective homogenously treated cohorts. We performed genome-wide miRNA microarray profiling of 74 diagnostic MCL samples from the Nordic MCL2trial (screening cohort). Prognosticmi RNAs were validated in diagnostic MCL samples from 94 patients of the independent Nordic MCL3 trial (validation cohort). Three miRNAs (miR-18b, miR-92a, and miR-378d) were significantly differentially expressed in patients who died of MCL in both cohorts. MiR-18b was superior to miR-92a and miR-378d in predicting high risk. Thus, we generated a new biological MCL International Prognostic Index (MIPI-B)-miR prognosticator, combining expression levels of miR-18b with MIPI-B data. Compared to the MIPI-B, this prognosticator improved identification of high-risk patients with regard to cause-specific, overall, and progression free survival. Transfection of 2 MCL cell lines with miR-18b decreased their proliferation rate without inducing apoptosis, suggesting that miR-18b may render MCL cells resistant to chemotherapy by decelerating cell proliferation. We conclude that overexpression of miR-18b identifies patients with poor prognosis in 2 large prospective MCL cohorts and adds prognostic information to the MIPI-B. MiR-18b may reduce the proliferation rate of MCL cells as a mechanism of chemoresistance.
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| 42. |
- Hyde, K. D., et al.
(författare)
-
Global consortium for the classification of fungi and fungus-like taxa
- 2023
-
Ingår i: MYCOSPHERE. - : Mushroom Research Foundation. - 2077-7000 .- 2077-7019. ; 14:1, s. 1960-2012
-
Tidskriftsartikel (refereegranskat)abstract
- The Global Consortium for the Classification of Fungi and fungus-like taxa is an international initiative of more than 550 mycologists to develop an electronic structure for the classification of these organisms. The members of the Consortium originate from 55 countries/regions worldwide, from a wide range of disciplines, and include senior, mid-career and early-career mycologists and plant pathologists. The Consortium will publish a biannual update of the Outline of Fungi and fungus-like taxa, to act as an international scheme for other scientists. Notes on all newly published taxa at or above the level of species will be prepared and published online on the Outline of Fungi website (https://www.outlineoffungi.org/), and these will be finally published in the biannual edition of the Outline of Fungi and fungus-like taxa. Comments on recent important taxonomic opinions on controversial topics will be included in the biannual outline. For example, 'to promote a more stable taxonomy in Fusarium given the divergences over its generic delimitation', or 'are there too many genera in the Boletales?' and even more importantly, 'what should be done with the tremendously diverse 'dark fungal taxa?' There are undeniable differences in mycologists' perceptions and opinions regarding species classification as well as the establishment of new species. Given the pluralistic nature of fungal taxonomy and its implications for species concepts and the nature of species, this consortium aims to provide a platform to better refine and stabilise fungal classification, taking into consideration views from different parties. In the future, a confidential voting system will be set up to gauge the opinions of all mycologists in the Consortium on important topics. The results of such surveys will be presented to the International Commission on the Taxonomy of Fungi (ICTF) and the Nomenclature Committee for Fungi (NCF) with opinions and percentages of votes for and against. Criticisms based on scientific evidence with regards to nomenclature, classifications, and taxonomic concepts will be welcomed, and any recommendations on specific taxonomic issues will also be encouraged; however, we will encourage professionally and ethically responsible criticisms of others' work. This biannual ongoing project will provide an outlet for advances in various topics of fungal classification, nomenclature, and taxonomic concepts and lead to a community-agreed classification scheme for the fungi and fungus-like taxa. Interested parties should contact the lead author if they would like to be involved in future outlines.
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| 43. |
- Ishfaq, A., et al.
(författare)
-
Multifunctional design, feasibility and requirements for structural power composites in future electric air taxis
- 2023
-
Ingår i: Journal of composite materials. - : SAGE Publications. - 0021-9983 .- 1530-793X. ; 57:4, s. 817-827
-
Tidskriftsartikel (refereegranskat)abstract
- This study investigates the viability of implementing multifunctional structural power composites in a four-seater air taxi, the CityAirbus. For a given specific energy of the power source, the cruise endurance can be approximately doubled by using structural power composites as opposed to conventional batteries. Replacing all the eligible composite mass and batteries with structural power composites can reduce the CityAirbus weight by 25%. To achieve the current design performance, the minimum required elastic modulus, strength, specific energy and power for the structural power composite are 54 GPa, 203 MPa, 74 Wh/kg and 376 W/kg, respectively: current state-of-the-art structural power composites are now approaching this level of performance. Hence, structural power composites are considered feasible for adoption in the urban air mobility sector and have the potential to improve endurance and facilitate commercialization. This paper also discusses several key challenges that must be addressed to realize the adoption of structural power composites in future electric air taxis.
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| 44. |
- Jansson, Natascha, 1987-
(författare)
-
Analysis of Dynamic Flight Loads
- 2012
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals with the determination of loads on an aircraft struc- ture during flight. The focus is on flight conditions where the loads are significantly time-dependent. Analysis of flight loads is primarily motivated to ensure that structural failure is avoided. The ability to ac- curately determine the resulting structural loads which can occur during operation allows for a reduction of the safety margins in the structural design. Consequently it is then possible to decrease the aircraft struc- tural weight. The demand for safe and fuel efficient aircraft creates a desire for efficient and accurate methods for determining the structural loads. The first paper of this thesis discusses the use of control laws for robust atmospheric turbulence load alleviation in the time domain. A numerical aircraft model including structural elasticity and unsteady aerodynamic effects is used. A limited set of longitudinal flight mechanic degrees of freedom are considered and two methods for structural load analysis are compared for evaluation of the wing root bending moment. In the second paper a method to perform time domain simulation of both motion of center of gravity and elastic deformation is described. The intention with the development of this simulation method is to enable efficient analysis of dynamic flight loads. A third study is finally included, where steady and unsteady pressure measurements have been carried out during wind tunnel testing. The motivation for performing these experiments is that knowledge about the aerodynamic force distribution which affect an aircraft structure is needed to correctly determine the structural loads.
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| 45. |
- Johannisson, Wilhelm, et al.
(författare)
-
A screen-printing method for manufacturing of current collectors for structural batteries
- 2021
-
Ingår i: Multifunctional Materials. - : IOP Publishing. - 2399-7532. ; 4:3, s. 035002-
-
Tidskriftsartikel (refereegranskat)abstract
- Structural carbon fibre composite batteries are a type of multifunctional batteries that combine the energy storage capability of a battery with the load-carrying ability of a structural material. To extract the current from the structural battery cell, current collectors are needed. However, current collectors are expensive, hard to connect to the electrode material and add mass to the system. Further, attaching the current collector to the carbon fibre electrode must not affect the electrochemical properties negatively or requires time-consuming, manual steps. This paper presents a proof-of-concept method for screen-printing of current collectors for structural carbon fibre composite batteries using silver conductive paste. Current collectors are screen-printed directly on spread carbon fibre tows and a polycarbonate carrier film. Experimental results show that the electrochemical performance of carbon fibre vs lithium metal half-cells with the screen-printed collectors is similar to reference half-cells using metal foil and silver adhered metal-foil collectors. The screen-printed current collectors fulfil the requirements for electrical conductivity, adhesion to the fibres and flexible handling of the fibre electrode. The screen-printing process is highly automatable and allows for cost-efficient upscaling to large scale manufacturing of arbitrary and complex current collector shapes. Hence, the screen-printing process shows a promising route to realization of high performing current collectors in structural batteries and potentially in other types of energy storage solutions.
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| 46. |
- Jönsson, Anders, et al.
(författare)
-
Microwave Ablation in Mitral Valve Surgery for Atrial Fibrillation (MAMA)
- 2012
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Ingår i: Journal of Atrial Fibrillation. - : Cardiofront. - 1941-6911. ; 5:2, s. 13-22
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Microwave ablation in conjunction with open heart surgery is effective in restoring sinus rhythm (SR) in patients with atrial fibrillation (AF). In patients assigned for isolated mitral valve surgery no prospective randomized trial has reported its efficacy.Methods: 70 patients with longlasting AF where included from 5 different centres. They were randomly assigned to mitral valve surgery and atrial microwave ablation or mitral valve surgery alone.Results: Out of 70 randomized, 66 and 64 patients were available for evaluation at 6 and 12 months. At 12 months SR was restored and preserved in 71.0 % in the ablation group vs 36.4 % in the control group (P=0.006), corresponding figures at 6 months was 62.5 % vs 26.5 % (P=0.003). The 30-day mortality rate was 1.4 %, with one death in the ablation group vs zero deaths in the control group. At 12 months the mortality rate was 7,1 % (Ablation n=3 vs Control n=2). No significant differences existed between the groups with regard to the overall rate of serious adverse events (SAE) during the perioperative period or at the end of the study. 16 % of patients randomized to ablation were on antiarrhytmic drugs compared to 6 % in the control group after 1 year (p=0.22).Conclusion: Microwave ablation of left and right atrium in conjunction with mitral valve surgery is safe and effectively restores sinus rhythm in patients with longlasting AF as compared to mitral valve surgery alone.
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| 47. |
- Karadotcheva, Elitza, et al.
(författare)
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Structural power performance targets for future electric aircraft
- 2021
-
Ingår i: Energies. - : MDPI AG. - 1996-1073 .- 1996-1073. ; 14:19
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Tidskriftsartikel (refereegranskat)abstract
- The development of commercial aviation is being driven by the need to improve efficiency and thereby lower emissions. All-electric aircraft present a route to eliminating direct fuel burning emissions, but their development is stifled by the limitations of current battery energy and power densities. Multifunctional structural power composites, which combine load-bearing and energy-storing functions, offer an alternative to higher-energy-density batteries and will potentially enable lighter and safer electric aircraft. This study investigated the feasibility of integrating structural power composites into future electric aircraft and assessed the impact on emissions. Using the Airbus A320 as a platform, three different electric aircraft configurations were designed conceptually, incorporating structural power composites, slender wings and distributed propulsion. The specific energy and power required for the structural power composites were estimated by determining the aircraft mission performance requirements and weight. Compared to a conventional A320, a parallel hybrid-electric A320 with structural power composites >200 Wh/kg could potentially increase fuel efficiency by 15% for a 1500 km mission. For an all-electric A320, structural power composites >400 Wh/kg could halve the specific energy or mass of batteries needed to power a 1000 km flight.
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| 48. |
- Linde, Anna-Malin, et al.
(författare)
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Evolutionary History of the Marchantia polymorpha Complex
- 2020
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Ingår i: Frontiers in Plant Science. - : Frontiers Media SA. - 1664-462X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- The potential role of introgression in evolution has gained increased interest in recent years. Although some fascinating examples have been reported, more information is needed to generalize the importance of hybridization and introgression for adaptive divergence. As limited data exist on haploid dominant species, we analyzed genomes of three subspecies of the liverwort Marchantia polymorpha. We used available genomic data for subsp. ruderalis and carried out whole-genome (PacBio) sequencing for one individual each of subsp. montivagans and subsp. polymorpha as well as Illumina resequencing of additional genomes for all three subspecies. The three subspecies were compared against M. paleacea as outgroup. Our analyses revealed separation of the three taxa, but all three possible topologies were richly represented across the genomes, and the underlying divergence order less obvious. This uncertainty could be the result of the divergence of the three subspecies close in time, or that introgression has been frequent since divergence. In particular, we found that pseudo-chromosome 2 in subsp. montivagans was much more diverged than other parts of the genomes. This could either be explained by specific capture of chromosome 2 from an unknown related species through hybridization or by conservation of chromosome 2 despite intermittent or ongoing introgression affecting more permeable parts of the genomes. A higher degree of chromosomal rearrangements on pseudo-chromosome 2 support the second hypothesis. Species tree analyses recovered an overall topology where subsp. montivagans diverged first and subsp. ruderalis and subsp. polymorpha appeared as sister lineages. Each subspecies was associated with its own chloroplast and mitochondrial haplotype group. Our data suggest introgression but refute a previous hypothesis that subsp. ruderalis is a new stabilized hybrid between the other two subspecies.
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| 49. |
- Linde, Peter, et al.
(författare)
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Accessibility and self-archiving of conference articles : A study on a selection of Swedish institutional repositories
- 2011
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Ingår i: Information Services and Use. - Guimarães : IOS Press. - 0167-5265 .- 1875-8789. ; 31:3-4, s. 259-269, s. 123-
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Tidskriftsartikel (refereegranskat)abstract
- The main purpose of this project has been to examine the accessibility of refereed conference articles and the OA- and publishing policies of conferences in order to in this way elucidate different aspects concerning self-archiving in Swedish institutional repositories. For this purpose, the project participants have examined a number of conferences and references to conference articles via their institutional repositories during a specific time period and described these from the perspective of a common scheme. The study has showed that the local institutional repositories fill an important role to make conference publications visible. We have found that ca. 50% of the conference papers can be published as postprints in our institutional repositories. We have noticed that ca. 15% or the studied conference articles are not available at all. It is, therefore, of great importance to use local institutional repositories as a publishing channel, not only for primary published material such as dissertations and reports, but also as a source for finding these conference articles "without a home". Between 20-25% of the examined articles were found in some type of OA archive; ca. half of these were found in one of the project participants' own institutional repositories. This indicates that the publishing database of respective higher education institution is an important factor for open accessibility. Ca. 10% of the conferences in the study had an explicit OA policy or expressed such a policy by openly making conference articles accessible on their conference sites. A big problem when it comes to self-archiving of conference articles is the lack of information about OA policy. The landscape of conference publishing is complex and the self-archiving of documents from conferences is very time-consuming. Above all, we would wish a policy resource for conferences similar to the SHERPA/RoMEO. At present, however, there is no other alternative than scrutinizing the conferences' copyright information to the authors and from this attempt to draw conclusions about possible self-archiving. To facilitate the future handling and classification of conference articles in Swedish institutional repositories a number of recommendations are suggested.
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| 50. |
- Linde, Peter, 1956-
(författare)
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Berättare från Oz : Australiska roman- och novellförfattare under 200 år - en introduktion
- 2021
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Bok (populärvet., debatt m.m.)abstract
- På 200 år förvandlades Australien från att ha varit dåtidens mest outforskade kontinent till ökänd straffkoloni och vidare tillnybyggar- och guldgrävarsamhälle och till sist till modernindustristat av västerländskt snitt — vilket berättarstoff måste inte finnas här!Nobelpristagaren Patrick White är omgiven av enmånghövdad och otålig kör av fantastiska berättarröster somgestaltar allt detta. Rösterna spänner från kapten Tenchsdokumentära ögonvittnesskildringar av mötet med den jungfruligakontinenten på 1790-talet till Peter Careys allegoriskasamtidsvisioner av australiskt liv på 1990-talet. Det finns ingetbättre sätt att upptäcka Australien än i deras sällskap!Med denna bok hoppas jag tillhandahålla ett verktyg, enkartskiss och guide för den nyfikne och för den som själv villutforska rikedomen i den australiska roman- och novellitteraturen.Skatterna finns där!Berättare från Oz gavs ut 1995 och finns inte längre att köpa i bokhandeln. Därför gör jag nu boken tillgänglig i digitalt format i tron att här fortfarande finns intressant information för den som är nyfiken på australisk litteratur. Jag har inte uppdaterat innehållet förutom litteraturlistorna som nu speglar vad som finns översatt till svenska fram till sommaren 2021.
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