| 1. |
- Surakka, Ida, et al.
(författare)
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The impact of low-frequency and rare variants on lipid levels.
- 2015
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:6, s. 589-597
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Tidskriftsartikel (refereegranskat)abstract
- Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, including 79 previously identified loci with new lead SNPs and 10 new loci, 15 loci with a low-frequency lead SNP and 10 loci with a missense lead SNP, and 2 loci with an accumulation of rare variants. In six loci, SNPs with established function in lipid genetics (CELSR2, GCKR, LIPC and APOE) or candidate missense mutations with predicted damaging function (CD300LG and TM6SF2) explained the locus associations. The low-frequency variants increased the proportion of variance explained, particularly for low-density lipoprotein cholesterol and total cholesterol. Altogether, our results highlight the impact of low-frequency variants in complex traits and show that imputation offers a cost-effective alternative to resequencing.
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| 2. |
- Andersson, Ulrika, 1977, et al.
(författare)
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Sprickor i fasaden (inledningskapitel)
- 2018
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Ingår i: Sprickor i fasaden. - Göteborg : Göteborgs iniversitet. - 0284-4788. ; , s. 11-40
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Bokkapitel (refereegranskat)abstract
- Det råder på sina håll en oro och ett mörker i debatten och föreställningarna om samhällets tillstånd. Bilder målas av en värld av kollapsande system och spruckna fasader, där de folkvalda fattar beslut som utarmar människors trygghet och livsvillkor. Det talas om det förljugna etablissemanget, om politisk korrekthet som ödelägger och förstör. Andra ser hur antidemokratiska krafter, likt början av förra seklet, växer sig större och tar allt mer plats på gator och torg. Somliga beskriver en demokrati i kris, om obönhörligt växande sprickbildningar i samhällsbygget. Och i spåren av dessa skeenden berättas hur otrygghetens och rädslans landskap breder ut sig. Världen som vi en gång kände den tycks långsamt glida ur våra händer. Den välputsade fasaden spricker. Samtidigt finns indikationer på att beskrivningen av samhällets förestående krackelering har chimäriska drag, en illusion framvuxen i en tid då det som tidigare varit etablerade normer och ideal på olika sätt utmanas och ifrågasätts. Kanhända är det så att samhällets palett skiftar i långt fler nyanser än mörkaste grått? Kanhända spirar det mitt ibland oss en värld fylld av möjligheter och förutsättningar för människor att leva, bo och utvecklas – tillsammans och sida vid sida? För i konstrast till bilden av samhällets rämnande grundvalar, kan skymtas skriftningar i den gemensamma värdegrunden i riktning mot ökad tolerans, öppenhet och jämlikhet. Kanske är dessa skiftningar tecken på att det förekommer en hel del sprickor också i föreställningen om den spruckna fasaden? Sprickor i fasaden är den sjuttioandra forskarantologin från SOM-institutet vid Göteborgs universitet. Titeln refererar till den sprickbildning i samhällsbygget som på olika håll har lyfts fram i den allmänna debatten. En del av de frågor som analyseras i boken påvisar också tydliga sprickor och polariseringstendenser – inte sällan i frågor som sträcker sig bortom den klassiska vänsterhögerdimensionen. Det är inte längre bara frågor som rör skatter, välfärdsstatens finansiering eller förhållandet mellan offentligt och privat som står för den största sprickbildningen. I många fall handlar det också om sociala och kulturella frågor som skapar skiljelinjer i befolkningen.
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| 3. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 4. |
- Damstra, Alyt, et al.
(författare)
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Knowledge and the News: An Investigation of the Relation Between News Use, News Avoidance, and the Presence of (Mis)beliefs
- 2023
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Ingår i: The International Journal of Press/Politics. - : SAGE Publications. - 1940-1612 .- 1940-1620. ; 28:1, s. 29-48
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Tidskriftsartikel (refereegranskat)abstract
- While increasing scholarly attention has been devoted to news avoidance, there are only few studies taking the distinction between intentional and unintentional news avoidance into consideration, and none that has investigated the linkage between the two types of news avoidance and knowledge about politics and society. To fill this void, this study explores this relationship while distinguishing between knowledge related to uncontested issues and knowledge related to issues that have been subject to public controversies (climate change, vaccination, genetically modified organisms, crime, and immigration). Relying on a large-scale survey among Swedish citizens conducted in 2020 (N = 2,160), we find that the relationship with patterns of news use is substantially different across these types of beliefs. Among other things, the results suggest that knowledge of uncontested issue domains is positively related to news use, but knowledge of contested issue domains is not. The intentional avoidance of news is only negatively related to knowledge of contested issues. Taken together, the results suggest that the mechanisms driving beliefs related to uncontested versus contested issues are substantially different.
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| 5. |
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| 6. |
- Damstra, Alyt, et al.
(författare)
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What does fake look like? A review of the literature on intentional deception in the news and on social media
- 2021
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Ingår i: Journalism Studies. - 1461-670X. ; 22:14, s. 1947-1963
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Tidskriftsartikel (refereegranskat)abstract
- This paper focuses on the content features of intentional deceptive information in the news (i.e., fake news) and on social media. Based on an extensive review of relevant literature (i.e., political journalism and communication, computational linguistics), we take stock of existing knowledge and present an overview of the structural characteristics that are indicative of intentionally deceptive information. We discuss the strength of underlying empirical evidence and identify underdeveloped areas of research. With this paper, we aim to contribute to the systematic study of intentional deception in the news and on social media and to help setting up new lines of research in which intentionally deceptive news items can be operationalized in consistent ways.
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| 7. |
- Do, Ron, et al.
(författare)
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Common variants associated with plasma triglycerides and risk for coronary artery disease
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1345-
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Tidskriftsartikel (refereegranskat)abstract
- Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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| 8. |
- Fall, Tove, et al.
(författare)
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The Role of Adiposity in Cardiometabolic Traits : A Mendelian Randomization Analysis
- 2013
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Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 10:6, s. e1001474-
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Tidskriftsartikel (refereegranskat)abstract
- Background: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. Methods and Findings: We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a Mendelian randomization design. Thirty-six population-based studies of individuals of European descent contributed to the analyses. Age-and sex-adjusted regression models were fitted to test for association between (i) rs9939609 and BMI (n = 198,502), (ii) rs9939609 and 24 traits, and (iii) BMI and 24 traits. The causal effect of BMI on the outcome measures was quantified by IV estimators. The estimators were compared to the BMI-trait associations derived from the same individuals. In the IV analysis, we demonstrated novel evidence for a causal relationship between adiposity and incident heart failure (hazard ratio, 1.19 per BMI-unit increase; 95% CI, 1.03-1.39) and replicated earlier reports of a causal association with type 2 diabetes, metabolic syndrome, dyslipidemia, and hypertension (odds ratio for IV estimator, 1.1-1.4; all p<0.05). For quantitative traits, our results provide novel evidence for a causal effect of adiposity on the liver enzymes alanine aminotransferase and gamma-glutamyl transferase and confirm previous reports of a causal effect of adiposity on systolic and diastolic blood pressure, fasting insulin, 2-h post-load glucose from the oral glucose tolerance test, C-reactive protein, triglycerides, and high-density lipoprotein cholesterol levels (all p<0.05). The estimated causal effects were in agreement with traditional observational measures in all instances except for type 2 diabetes, where the causal estimate was larger than the observational estimate (p = 0.001). Conclusions: We provide novel evidence for a causal relationship between adiposity and heart failure as well as between adiposity and increased liver enzymes.
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| 9. |
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| 10. |
- Horikoshi, Momoko, et al.
(författare)
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Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
- 2015
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), supplemented by 1000G imputation, for four quantitative glycaemic and obesity-related traits, in up to 87,048 individuals of European ancestry. We identified two loci for body mass index (BMI) at genome-wide significance, and two for fasting glucose (FG), none of which has been previously reported in larger meta-analysis efforts to combine GWAS of European ancestry. Through conditional analysis, we also detected multiple distinct signals of association mapping to established loci for waist-hip ratio adjusted for BMI (RSPO3) and FG (GCK and G6PC2). The index variant for one association signal at the G6PC2 locus is a low-frequency coding allele, H177Y, which has recently been demonstrated to have a functional role in glucose regulation. Fine-mapping analyses revealed that the non-coding variants most likely to drive association signals at established and novel loci were enriched for overlap with enhancer elements, which for FG mapped to promoter and transcription factor binding sites in pancreatic islets, in particular. Our study demonstrates that 1000G imputation and genetic fine-mapping of common and low-frequency variant association signals at GWAS loci, integrated with genomic annotation in relevant tissues, can provide insight into the functional and regulatory mechanisms through which their effects on glycaemic and obesity-related traits are mediated.
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| 11. |
- Ikram, M. Arfan, et al.
(författare)
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Common variants at 6q22 and 17q21 are associated with intracranial volume
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 539-544
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Tidskriftsartikel (refereegranskat)abstract
- During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
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| 12. |
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| 13. |
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| 14. |
- Lindgren, Elina
(författare)
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Campaigning in Poetry, Governing in Prose: Pre- and Post-Election Effects of Election Pledge Rhetoric
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In election campaigns, parties often use value-laden words such as freedom and competitiveness, to reach out to voters with their election pledges and policy proposals. While it is well known that the presence of such words in election pledges can impact voters’ support for policy proposals, we know less about what makes these words effective. In her dissertation, Elina Lindgren presents and tests a linguistic explanation of how value-laden words can affect, not only the extent to which voters appreciate a policy proposal, but also how they perceive the actual content of the policy. Through a series of survey experiments, she shows that the presence of words such as freedom and competitiveness in election pledges can elicit substantive beliefs about policies that go beyond the actual content of the proposals outlined in the pledges. This, in turn, may lead to (mis)interpretations of how the policies and their future outcomes align with the voters’ policy preferences. Lindgren also shows how these interpretations can make it more difficult for politicians to meet the voters’ expectations of the election pledges post-election, and how they may lead to perceptions that the pledges have been broken. These results raise questions about the well-being of a central part of a representative democracy. If value-laden words in election pledges can create expectations of policy proposals beyond what is actually being pledged, it may become more difficult for voters to predict which parties will best represent their policy preferences – something that is crucial to a representative democracy.
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| 15. |
- Lindgren, Elina
(författare)
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Changing Policy With Words: How Persuasive Words in Election Pledges Influence Voters’ Beliefs About Policies
- 2018
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Ingår i: Mass Communication & Society. - : Informa UK Limited. - 1520-5436 .- 1532-7825. ; 21:4, s. 425-449
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Tidskriftsartikel (refereegranskat)abstract
- Parties often frame their election pledges with value-laden words such as freedom and equality, and it is well known that this can influence voters’ support for policies. However, research is not conclusive about why as of yet. This article adds to common explanations of value-framing effects by proposing a linguistic explanation to how citizens are influenced by value words in election pledges. Drawing on what linguistic theory says about persuasive words, this article hypothesizes that value-laden words elicit different beliefs about policy content, beyond what has actually been pledged. To support this assertion, a survey experiment (N = 739) shows that such words do provoke different beliefs about policies and that this, in turn, influences the extent to which individuals support the policies. The findings have implications for representative democracy, as they indicate that voters’ outspoken support for policy pledges do not necessarily reflect their true policy preferences.
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| 16. |
- Lindgren, Elina, et al.
(författare)
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Election pledge rhetoric: Selling policy with words.
- 2015
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Ingår i: Paper presented at the Annual Meeting of the American Political Science Association (APSA), San Francisco, 3-6 September 2015. Division 36: Elections and voting behavior. Panel: Voters and Mandates: Evaluating Specific Accountability Processes..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 17. |
- Lindgren, Elina, et al.
(författare)
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Election Pledge Rhetoric: Selling Policy with Words
- 2017
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Ingår i: International Journal of Communication. - 1321-6597. ; 11, s. 2198-2219
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Tidskriftsartikel (refereegranskat)abstract
- This article investigates the possibilities that political parties have to sell specific policies to a broad electorate by use of persuasive words in election pledges. Prior research has shown that parties can increase their electoral support by targeting different groups of voters with different policies or by moderating policy platforms to the center. We investigate whether voters’ appreciation of specific policy pledges increases when rhetoric is used to appeal broadly. Inspired by literature on philosophy of language and linguistic semantics, we designed a survey experiment in which 1,960 Swedish citizens evaluated election pledges. We randomized whether the policy was described using universal persuasive words. Results showed that universal persuasive words increase the appreciation of specific policy pledges, particularly among individuals oriented close to and at the center of the ideological left–right scale (the median voters). The effects decrease with ideological (left and right) extremity. In times when center voters become increasingly important for election outcomes, indications that they are susceptible to universal, but left–right ideology-neutral, rhetoric are interesting both for parties and scholars of the same.
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| 18. |
- Lindgren, Elina, et al.
(författare)
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Invitation Timing and Participation Rates in Online Panels: Findings From Two Survey Experiments
- 2020
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Ingår i: Social Science Computer Review. - : SAGE Publications. - 0894-4393 .- 1552-8286. ; 38:2, s. 225-244
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Tidskriftsartikel (refereegranskat)abstract
- Falling participation rates is one of the most significant challenges facing survey research today. To curb this negative trend, scholars have searched for factors that can increase and decrease citizens’ willingness to participate in surveys. In this article, we investigate the timing effects of survey invitation e-mails on participation rates in a university-based online panel with members of the Swedish public. Through two large-scale experimental studies, we examine whether the day of week (N = 11,294) and time of day (N = 47,279) for sending out survey invitations impact participation rates. We also ask respondents when they prefer to answer surveys. We find that the timing of survey invitations affects participation rates, however, the effects are small, short-lived, and even out within a week. We also find that the effects of timing vary by employment status and age. The results have implications for scholars and practitioners who utilize online panels for web surveys. When quick answers are important, there may be some limited gains of tailoring the timing of the survey invitation to different individuals. In surveys with more extended field periods, however, such efforts seem less warranted.
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| 19. |
- Lindgren, Elina, et al.
(författare)
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Trusting the Facts: The Role of Framing, News Media as a (Trusted) Source and Opinion Resonance for Perceived Truth in Statistical Statements
- 2022
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Ingår i: Journalism & Mass Communication Quarterly. - : SAGE Publications. - 1077-6990 .- 2161-430X.
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Tidskriftsartikel (refereegranskat)abstract
- Scholars have raised concerns that on many issues, citizens are reluctant to trust factual evidence and statistics. One factor that has been shown to impact the perceived truth in statistics is how they are presented, where negatively framed statistics are perceived as truer than positive. This study explores when this bias applies and not. Results from a survey experiment confirm the presence of a negativity bias in truth perceptions, but also that effects are heterogeneous and moderated by, in particular, the recipients’ preexisting opinions. These findings provide valuable information to public actors responsible for disseminating factual information to diverse publics.
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| 20. |
- Lindgren, Elina, et al.
(författare)
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Trusting the facts: The role of framing, news media as a (trusted) source, and opinion resonance on perceived truth in statistical statements.
- 2022
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Ingår i: Paper presented at the International Communication Association annual conference.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Scholars have raised concerns that on many issues, citizens are reluctant to trust factual evidence and statistics. One factor that has been shown to impact the perceived truth in statistics is how they are presented, where negatively framed statistics are perceived truer than positive. This study explores when this bias may apply and not. Results from a survey experiment confirm the presence of a negativity bias in truth perceptions, but also that effects are heterogeneous and moderated by, in particular, the recipients’ pre-existing opinions. These findings provide valuable information to public actors responsible for disseminating factual information to diverse publics.
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| 21. |
- Lindgren, Elina
(författare)
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(Un)Expected effects of policy rhetoric: value framing of policy proposals and voters’ reactions to subsequent information
- 2022
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Ingår i: Acta Politica. - : Springer Science and Business Media LLC. - 0001-6810 .- 1741-1416. ; 57, s. 836-863
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Tidskriftsartikel (refereegranskat)abstract
- It is well-established that value framing can be a powerful rhetorical tool for politicians to influence voters’ expectations of policies and muster support. The effects that such policy framing may have on people’s reactions to subsequent policy information, however, remain largely unexplored. This paper addresses this question by investigating whether value framing of policy proposals can influence the aspects that people consider important when they receive (and evaluate) information regarding policy outcomes, as well as their satisfaction with them. A survey experiment (N=2378) demonstrates that, when individuals have been exposed to information on outcomes, they sometimes consider the framed values more important than the actual policy measures. The experiment also indicates that value framing may sometimes influence satisfaction with the outcomes. However, these effects are in the positive rather than the hypothesized (negative) direction. Both effects primarily appear when the frames are charged with humanitarian values. Implications of the findings are discussed.
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| 22. |
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| 23. |
- Lindgren, Elina
(författare)
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Är det skillnad på invandring och invandring? Attityder till arbetskrafts- och flyktinginvandring i Sverige : Is there a difference between immigration and immigration? Attitudes to labor- and refugee immigration in Sweden
- 2018
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Ingår i: Sprickor i fasaden. - Göteborg : Göteborgs universitet.
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Bokkapitel (refereegranskat)abstract
- Efter att ha varit relativt frånvarande i den politiska debatten i början av 2000-talet har invandringspolitiken de senaste åren seglat upp som en av de hetaste frågorna i Sverige. I den här rapporten undersöks sambandet mellan attityder till invandring och ett antal faktorer som tidigare visat sig ligga till grund för sådana attityder, såsom oro för ekonomin, välfärdssystemet och den nationella sammanhållningen, samt sambandet med partisympati. Hur dessa faktorer återspeglas i attityder till arbetskraftsinvandring respektive flyktinginvandring hos svenska folket testas genom analyser av 2017 (arbetskraftsinvandring) respektive 2016 (flyktinginvandring) års nationella SOM-undersökning. Resultaten visar att det finns samband mellan olika orosaspekter såväl som partisympati, och attityder till invandring. Det framkommer också att det, trots att förklaringsmönstren ofta liknar varandra, finns vissa skillnader när det gäller attityder till arbetskraftsinvandring respektive flyktinginvandring – något som indikerar att det ibland görs en skillnad mellan olika former av invandring.
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| 24. |
- Lindgren, Elina
(författare)
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Ökad arbetskraftsinvandring: Är löntagare och arbetsgivare överens? : Increased labor migration: Do employees and employers agree?
- 2019
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Ingår i: Storm och stiltje (ISSN: 0284-4788). - Bohus : Ale Tryckteam. - 0284-4788. - 9789189673441 ; , s. 373-393
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Under 2000-talet har ett flertal politiska reformer genomförts för att underlätta för arbetsgivare i Sverige att rekrytera personer från andra länder – något som också lett till en ökning av arbetskraftsinvandringen. Trots att det skett stora förändringar på det politiska planet inom detta område under senare år finns förvånansvärt få studier gjorda på medborgarnas attityder till arbetskraftsinvandring. I det här kapitlet undersöks därför svenska folkets attityder till arbetskraftsinvandring 2018, samt vilka faktorer som kan påverka om en individ är positiv respektive negativ till en ökad arbetskraftsinvandring. I fokus för studien står löntagares och arbetsgivares attityder till arbetskraftsinvandring, samt hur attityder kan påverkas av individens uppfattningar om samhällsekonomin, välfärdsinstitutionerna, och situationen på arbetsmarknaden. Resultaten visar att attityder till arbetskraftsinvandring varierar både när det gäller uppfattningar kring landets välfärdsinstitutioner och ekonomi, och individens egen position på arbetsmarknaden.
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| 25. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 26. |
- Middeldorp, Christel M., et al.
(författare)
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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia : design, results and future prospects
- 2019
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 34:3, s. 279-300
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Tidskriftsartikel (refereegranskat)abstract
- The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
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| 27. |
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| 28. |
- Nakeva von Mentzer, Cecilia, et al.
(författare)
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Coputer based phonological intervention : Effects on phonological processing
- 2012
-
Konferensbidrag (refereegranskat)abstract
- Children with mild to profound hearing impairment (HI) using cochlear implants (CI) and/or hearingaids (HA), and children with normal hearing (NH) participated in a phonological intervention study, bymeans of a computer‐based intervention program (Graphogame, Lyytinen et al., 2009). Children were 5,6 and 7 years of age. Thirty‐two of the children used CI and/or HA. 16 children with NH served as thecontrol group. The main design was a quasi‐experimental 3 x 3 design. Each test session was separatedin time with four weeks. All children were asked to practice 10 minutes per day at home supported bytheir parents, with an intervention program primarily developed to enhance phonemic differentiation.Results showed that the children with HI displayed a heterogeneous pattern of results, specifically withrespect to their performance on the phonological tasks. Approximately 20 percent performed within therange of NH children; these were all children with HA except one child with CI/HA. Children with CIdisplayed considerable difficulty with phonological working memory whereas children with HAshowed less knowledge in letter tasks. Intervention revealed positive effects on accuracy of phonemegraphemecorrespondence for all children and a significant positive change on phonological processingskills for children with weak initial phonological skills. Enhanced phoneme‐grapheme connections maybuild associations between the phonological lexicon and the sub‐lexical phonological representations,thereby improving underlying skills essential for word learning and the development of literacy. Implicationsof this are discussed within theoretical models of phonological and lexical processing (Goswami,2000; Ramus, 2001).
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| 29. |
- Pervjakova, Natalia, et al.
(författare)
-
Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes
- 2022
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 31:19, s. 3377-3391
-
Tidskriftsartikel (refereegranskat)abstract
- Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy (GenDIP) Consortium assembled genome-wide association studies (GWAS) of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. Through multi-ancestry meta-analysis, we identified five loci with genome-wide significant association (p < 5x10-8) with GDM, mapping to/near MTNR1B (p = 4.3x10-54), TCF7L2 (p = 4.0x10-16), CDKAL1 (p = 1.6 × 10-14), CDKN2A-CDKN2B (p = 4.1x10-9) and HKDC1 (p = 2.9x10-8). Multiple lines of evidence pointed to the shared pathophysiology of GDM and T2D: (i) four of the five GDM loci (not HKDC1) have been previously reported at genome-wide significance for T2D; (ii) significant enrichment for associations with GDM at previously reported T2D loci; (iii) strong genetic correlation between GDM and T2D; and (iv) enrichment of GDM associations mapping to genomic annotations in diabetes-relevant tissues and transcription factor binding sites. Mendelian randomisation analyses demonstrated significant causal association (5% false discovery rate) of higher body mass index on increased GDM risk. Our results provide support for the hypothesis that GDM and T2D are part of the same underlying pathology but that, as exemplified by the HKDC1 locus, there are genetic determinants of GDM that are specific to glucose regulation in pregnancy.
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| 30. |
- Pilemalm, Sofie, et al.
(författare)
-
Emerging forms of inter-organizational and cross-sector collaborations in e-government initiatives : Implications for participative development of information systems
- 2016
-
Ingår i: Transforming Government. - : Emerald Group Publishing Limited. - 1750-6166 .- 1750-6174. ; 10:4, s. 605-636
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose – This study aims to explore recent public sector trends, inter-organizational and cross-sectorcollaborations, and analyzes these in terms of implications for participative development of informationsystems (IS). These trends are understood as being part of emerging forms of e-government. Initialsuggestions for how to develop IS in the new contexts are provided.Design/methodology/approach – Three cases involving the trends described above, taking place inthe Swedish emergency response system, are studied and used as basis for identified participative ISdevelopment challenges and suggested adaptation needs. Data collection involves semi-structuredinterviews, focus groups and future workshops.Findings – The identified challenges concern balancing ideological versus practical needs, lack ofresources, lack of know-how and design techniques and tool challenges. Some practical implications forparticipative IS development include more extensive focus on stakeholder and legal analysis, need forinterdisciplinary design teams, merging of task and needs analysis for yet-undefined user tasks andusing on-line alternatives for interacting with users.Research implications/limitations – The study is exploratory where the three cases are indifferent, but at the same time interrelated, collaboration contexts. The identified implications andchallenges provide proposals that in future research can be applied, formalized and integrated whendeveloping practically feasible participative IS development approaches.Originality/value – It is argued that the results point toward a current emerging form ofe-government initiatives directed toward certain demarcated groups of citizens actually carrying outcertain tasks for their co-citizens and society rather than the broad masses, having far-reachingpractical implications and complicating the issue of IS development.
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| 31. |
- Pilemalm, Sofie, et al.
(författare)
-
Fourth Generation of User-centered Design : eveloping for E-government and Cross-sector Collaborations.
- 2015
-
Ingår i: In Electronic Government and Electronic Participation. - : IOS Press. ; , s. 178-192
-
Konferensbidrag (refereegranskat)abstract
- This study explores the need for user-centered design (UCD) approaches to adapt to recent societal trends of cross-sector collaborations, civil citizen involvement and e-government initiatives affecting the public sector. This is achieved by studying three cases involving such trends, taking place in the Swedish Emergency Response System. Using results from the cases, information systems development related challenges are identified and related to adaption needs for current UCD approaches. Suggestions of such adaption are provided and a number of inherent challenges for the fourth generation of UCD are discussed, including challenges concerning (a) balancing ideological versus practical needs; (b) resources; (c) lack of know-how; and (d) design techniques and tool challenges.
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| 32. |
- Ramsell, Elina, 1981-
(författare)
-
Toward ICT-enabled Co-production for Effective Crisis and Emergency Response
- 2021
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In contemporary society, public services struggle to maintain a high quality of service if the authority responsible for the service delivery experiences resource deficit and increased uncertainties and vulnerabilities. This thesis explores how information and communication technology (ICT) can enable new types of network collaborations – co-production – between government (municipalities) and citizens, for a more effective crisis and emergency response. This is explored in the light of digitalization and taking an end-user perspective. The thesis’s first objective is to describe the transformation toward ICT-enabled co-production. The second objective is to identify opportunities and challenges involved in ICT-enabled co-production. The thesis’s method includes two case studies supported by various theories and approaches: network collaboration (including co-production), sociotechnical systems, and end-user involvement. The data collection is conducted using semi-structured interviews, focus groups, user participation techniques, and document reviews. The intended audience is practitioners (local government and national agencies) and researchers within crisis and emergency response, information systems (IS), and public administration research disciplines and domains (e.g. co-production). The description of the transformation toward ICT-enabled coproduction in crisis and emergency response is a result in its own right. Here, the citizen volunteers become involved in the actual delivery of the response, despite non-specific competence and non-organizational affiliation. In relation to the transformation toward co-production, the thesis concludes that digitalization facilitates end-user involvement in the ICT development process and increases their influence. If open systems as mobile technologies are used, end-users can adapt the technology on their own and add technologies, without the support of the formal developer or local government. The thesis also identifies opportunities and challenges of ICT-enabled co-production. Examples of opportunities include citizen volunteers having a high degree of engagement, being an effective complement to professional responders, and increasing perceived safety in the community. This informal structure of co-production enabled by ICT minimizes the need for local governments to spend resources on managing collaboration. Examples of challenges include the lack of organizational affiliation of volunteers (e.g. integration of citizen volunteers, i.e. end-users with non-organizational affiliation in the technology of the ICT system) and aspects of formal and social control (regulation, and moral and privacy issues). The thesis’s contributions include enriched knowledge of essential aspects to consider when developing ICT-enabled co-production with an end-user perspective, and an understanding of the transformation of the application domain over time and the implications of ICT-enabled coproduction. This makes it easier to comprehend and develop contemporary and future co-productions. The thesis is perceived to have high originality and value since it studies time periods in which local government, technology, and crisis and emergency response have undergone dramatic changes, and explores one of the first Swedish empirical initiatives involving citizen volunteers as responders.
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| 33. |
- Sayeed, Asad, 1980, et al.
(författare)
-
The utility of (political) dogwhistles – a life cycle perspective
- 2024
-
Ingår i: Journal of Language and Politics. - 1569-2159.
-
Tidskriftsartikel (refereegranskat)abstract
- The term dogwhistle refers to an expression conveying a message to a subset of an audience which is not perceived by the rest of the group, in addition to a primary meaning directed at the group at large. We follow up on previous work in linguistics and political communication on defining dogwhistles, taking into account how they likely function in real-life political contexts. We consider the utility of dogwhistles in terms of their sensitivity and their specificity, which allows us to consider dogwhistles in terms of an idealized “life cycle”, whose phases we describe in terms of a multi-dimensional utility tradeoff, described in terms of dogwhistle users, the benefit they expect to receive from dogwhistling, and the deniability of controversial dogwhistle meanings. We propose an approach for the longitudinal study of dogwhistles, and describe the first stages of an experiment to characterize dogwhistles in terms of their lexical properties.
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| 34. |
- Shungin, Dmitry, et al.
(författare)
-
New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
-
Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 35. |
- Smith, Jennifer A, et al.
(författare)
-
Genome-wide association study identifies 74 loci associated with educational attainment
- 2016
-
Ingår i: Nature (London). - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 533:7604, s. 539-542
-
Tidskriftsartikel (refereegranskat)abstract
- Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
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| 36. |
-
Sprickor i fasaden
- 2018
-
Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Det råder på sina håll en oro och ett mörker i dagens Sverige. Några grupper ser en värld av kollapsande system och spruckna fasader, där folkvalda fattar beslut som utarmar människors trygghet och livsvillkor. Andra ser hur antide-mokratiska krafter, likt början av förra seklet, växer sig allt större och på sina håll ges legitimitet av världsledare. Somliga går så långt som att tala om en demokrati i kris, om obönhörligt växande sprickbildningar i samhällsbygget i spåren av vilka otrygghetens och rädslans landskap breder ut sig. Sprickor i fasaden knyter an till denna rådande debatt och föreställningar om samhällets tillstånd.Världen som vi en gång kände den tycks långsamt glida ur våra händer. Den välputsade fasaden spricker. Eller gör den det? Kanske skiftar samhällets palett i långt fler nyanser än mörkaste grått? Kanske spirar det rent av en värld med allt godare möjligheter för människor att leva och utvecklas? För i kontrast till bilden av samhällets rämnande grundvalar, kan också skymtas skiftningar i värdegrunden i riktning mot ökad tolerans, öppenhet och jämlikhet. Måhända är dessa skiftningar tecken på sprickor också i föreställningen om den spruck-na fasaden? Sprickor i fasaden är den 72:e forskarantologin från SOM-institutet och bygger på 2017 års nationella SOM-undersökning – den trettioandra i ordningen. Bokens innehåll knyter på många sätt an till frågan om sprickor i det svenska samhällsbygget. Flera kapitel belyser tilltagande polarisering och politisering inom (S)amhälle, (O)pinion och (M)edier. Samtidigt pekar resultaten i andra kapitel på en påtaglig stabilitet och förstärkt uppslutning kring centrala värde-ringar, samhällsfrågor och samhällsinstitutioner.Sprickor i fasaden är skriven av ett 30-tal forskare från olika discipliner vid universitet och högskolor i Sverige.
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| 37. |
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| 38. |
- Strömbäck, Jesper, 1971, et al.
(författare)
-
Conspiracy thinking and the role of media use: Exploring the antecedents of conspiratorial predispositions
- 2023
-
Ingår i: European Journal of Communication. - : SAGE Publications. - 0267-3231 .- 1460-3705. ; 38:3, s. 255-271
-
Tidskriftsartikel (refereegranskat)abstract
- In contrast to beliefs in specific conspiracy theories, conspiratorial predispositions refer to people's propensity to view the world in conspiratorial terms. As such, they are one of the most important antecedents of beliefs in specific conspiracy theories. Understanding the antecedents of conspiratorial predispositions is hence important. Despite this, there is still only limited research on the antecedents of conspiratorial predispositions. Previous research has also not taken the role of media use into account, even though media constitute the most important source of politically and societally information. To remedy this, in the current study we use a large-scale panel study in Sweden to investigate the antecedents of conspiratorial predispositions, with a particular focus on the role of media use. Among other things, the results show that use of right-wing political alternative media is one of the most important antecedents of conspiratorial predispositions, even when accounting for ideological leaning and ideological extremity.
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| 39. |
- Strömbäck, Jesper, 1971, et al.
(författare)
-
Conspiracy thinking and the role of media use: Exploring the antecedents of generic conspiracist beliefs
- 2022
-
Ingår i: Paper presented at the annual International Communication Association conference.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- While conspiracy thinking has become a more pressing social problem, thus far, most research has focused on beliefs in specific conspiracy theories. Less attention has been paid to generic conspiracist beliefs, despite findings that such beliefs are among the most important predictors of beliefs in specific conspiracy theories. There is also very limited research on how media use may impact generic conspiracist beliefs. The purpose of this paper is hence to investigate the antecedents of generic conspiracist beliefs, with a particular focus on the role of media use. Utilizing a large-scale representative panel survey in Sweden, we find that media use matters, and that use of right-wing political alternative media is one of the strongest predictors of generic conspiracist beliefs.
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| 40. |
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| 41. |
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| 42. |
- Strömbäck, Jesper, 1971, et al.
(författare)
-
News media trust and its impact on media use : toward a framework for future research
- 2020
-
Ingår i: Annals of the International Communication Association. - : Informa UK Limited. - 2380-8985 .- 2380-8977. ; 44:2, s. 139-156
-
Tidskriftsartikel (refereegranskat)abstract
- In contemporary high-choice media environments, the issue of media trust and its impact on people's media use has taken on new importance. At the same time, the extent to which people trust the news media and how much it matters for their use of different types of media is not clear. To lay the groundwork for future research, in this article we offer a focused review of (a) how news media trust has been conceptualized and operationalized in previous research and (b) research on the extent to which news media trust influences media use, and (c) offer a theoretically derived framework for future research on news media trust and its influence on media use.
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| 43. |
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| 44. |
- Strömbäck, Jesper, 1971, et al.
(författare)
-
Political Opinion Leaders in High-Choice Information Environments: Are They More Informed Than Others?
- 2023
-
Ingår i: Mass Communication & Society. - 1520-5436.
-
Tidskriftsartikel (refereegranskat)abstract
- One implication of the transition to high-choice media environments is that what information people are exposed to depend less on journalistic curation and more on social, algorithmic, and personal curation. This has sparked a renewed interest in the concept of political opinion leaders, who are often assumed to be more interested in and informed about politics and society. Theoretically, political opinion leaders could hence help disseminate information to less interested and informed. At the same time, there are theoretical reasons for why political opinion leaders may be more prone to politically motivated reasoning, which may lead them to believe in and disseminate misinformation. Thus far, there is only limited research on whether political opinion leaders are more informed than others that also takes into consideration that some facts are contested, whereas other facts are uncontested. Hence, this paper seeks to investigate the relationship between political opinion leadership and knowledge, distinguishing between (a) uncontested and (b) contested facts. Among other things, findings show that those who score high in political opinion leadership traits in general are not more knowledgeable about contested and uncontested facts.
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| 45. |
- Taal, H. Rob, et al.
(författare)
-
Common variants at 12q15 and 12q24 are associated with infant head circumference
- 2012
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 532-538
-
Tidskriftsartikel (refereegranskat)abstract
- To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
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| 46. |
- Tsfai, Yariv, et al.
(författare)
-
Causes and consequences of mainstream media dissemination of fake news: literature review and synthesis
- 2020
-
Ingår i: Annals of the International Communication Association. - : Informa UK Limited. - 2380-8985 .- 2380-8977. ; 44:2, s. 157-173
-
Tidskriftsartikel (refereegranskat)abstract
- Research indicates that the reach of fake news websites is limited to small parts of the population. On the other hand, data demonstrate that large proportions of the public know about notable fake news stories and believe them. These findings imply the possibility that most people hear about fake news stories not from fake news websites but through their coverage in mainstream news outlets. Thus far, only limited attention has been directed to the role of mainstream media in the dissemination of disinformation. To remedy this, this article synthesizes the literature pertaining to understand the role mainstream media play in the dissemination of fake news, the reasons for such coverage and its influences on the audience.
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| 47. |
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| 48. |
- Tsfati, Yariv, et al.
(författare)
-
Going Beyond General Media Trust: An Analysis of Topical Media Trust, its Antecedents and Effects on Issue (Mis) perceptions
- 2022
-
Ingår i: International Journal of Public Opinion Research. - : Oxford University Press (OUP). - 0954-2892 .- 1471-6909. ; 34:2
-
Tidskriftsartikel (refereegranskat)abstract
- A key problem with research on news media trust is that it has mostly focused on general media trust and that there is limited research on how media trust might vary across levels of analysis. In this paper, we seek to remedy this by investigating whether news media trust differs depending on the topic of news coverage and whether topical trust can be distinguished from general media trust. We also investigate the antecedents of trust in news coverage of different topics and the effects of topical trust on issue (mis)perceptions. Among other things, findings show that topical media trust can be distinguished from general media trust and is a better predictor of correct perceptions on political matters.
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| 49. |
- Tsfati, Yariv, et al.
(författare)
-
What news outlets do people have in mind when they answer survey questions about trust in "media"?
- 2023
-
Ingår i: International journal of public opinion research. - 0954-2892 .- 1471-6909. ; 35:2
-
Tidskriftsartikel (refereegranskat)abstract
- While ample research on audience trust in the news media uses survey questions that ask respondents about their trust in a generic “news media,” only scant research has investigated what types of news outlets respondents have in mind when answering such questions. These previous investigations originated mostly in the US and resulted in inconsistent findings. To further investigate this question, we use data from a large-scale survey (N = 2,337), collected in Sweden, including both general media trust measures and specific measures about trust in 20 mainstream and nonmainstream news outlets. The results demonstrate that our respondents seemingly averaged across all mainstream sources when they formed their general evaluations of the news media’s trustworthiness.
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| 50. |
- Vliegenthart, Rens, et al.
(författare)
-
Taking Political Alternative Media into Account: Investigating the Linkage Between Media Repertories and (Mis)perceptions.
- 2023
-
Ingår i: Mass Communication & Society. - 1520-5436.
-
Tidskriftsartikel (refereegranskat)abstract
- In most studies on news repertoires and the linkage between media use and (mis)perceptions of social and political matters, the use of political alternative media has not been included. In this paper, we therefore investigate how people combine both traditional and political alternative media into different media repertoires, and how these media repertoires are related to misperceptions. We rely on a two-wave panel survey, conducted in 2020 and 2021, with a probability-recruited sample of the Swedish population. Measures on the use of a wide range of media, including political alternative ones, are used to conduct a Latent Profile Analysis. This analysis distinguishes five media repertoires in the data. The results show that these repertoires coincide with different levels of misperceptions, with those dominated by TV use showing higher levels of misperceptions and those with higher newspaper and alternative media use showing lower levels of misperceptions. Results also show that media repertoires do not affect over-time changes in misperceptions.
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