| 1. |
- Lewis, Cathryn M, et al.
(författare)
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Genome scan meta-analysis of schizophrenia and bipolar disorder, part II : Schizophrenia
- 2003
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Ingår i: American Journal of Human Genetics. - 0002-9297 .- 1537-6605. ; 73:1, s. 34-48
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk<.000417). Two aggregate criteria for linkage were also met (clusters of nominally significant P values that did not occur in 1,000 replicates of the entire data set with no linkage present): 12 consecutive bins with both P(AvgRnk) and P(ord)<.05, including regions of chromosomes 5q, 3p, 11q, 6p, 1q, 22q, 8p, 20q, and 14p, and 19 consecutive bins with P(ord)<.05, additionally including regions of chromosomes 16q, 18q, 10p, 15q, 6q, and 17q. There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
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| 2. |
- Akrami, Y., et al.
(författare)
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Planck 2018 results : XI. Polarized dust foregrounds
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 641
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Tidskriftsartikel (refereegranskat)abstract
- The study of polarized dust emission has become entwined with the analysis of the cosmic microwave background (CMB) polarization in the quest for the curl-like B-mode polarization from primordial gravitational waves and the low-multipole E-mode polarization associated with the reionization of the Universe. We used the new Planck PR3 maps to characterize Galactic dust emission at high latitudes as a foreground to the CMB polarization and use end-to-end simulations to compute uncertainties and assess the statistical significance of our measurements. We present PlanckEE, BB, and TE power spectra of dust polarization at 353 GHz for a set of six nested high-Galactic-latitude sky regions covering from 24 to 71% of the sky. We present power-law fits to the angular power spectra, yielding evidence for statistically significant variations of the exponents over sky regions and a difference between the values for the EE and BB spectra, which for the largest sky region are alpha (EE)=-2.42 +/- 0.02 and alpha (BB)=-2.54 +/- 0.02, respectively. The spectra show that the TE correlation and E/B power asymmetry discovered by Planck extend to low multipoles that were not included in earlier Planck polarization papers due to residual data systematics. We also report evidence for a positive TB dust signal. Combining data from Planck and WMAP, we have determined the amplitudes and spectral energy distributions (SEDs) of polarized foregrounds, including the correlation between dust and synchrotron polarized emission, for the six sky regions as a function of multipole. This quantifies the challenge of the component-separation procedure that is required for measuring the low-l reionization CMB E-mode signal and detecting the reionization and recombination peaks of primordial CMB B modes. The SED of polarized dust emission is fit well by a single-temperature modified black-body emission law from 353 GHz to below 70 GHz. For a dust temperature of 19.6 K, the mean dust spectral index for dust polarization is beta (P)(d) = 1.53 +/- 0.02 beta d P = 1.53 +/- 0.02 . The difference between indices for polarization and total intensity is beta (P)(d)-beta (I)(d) = 0.05 +/- 0.03 beta d P - beta d I =0.05 +/- 0.03 . By fitting multi-frequency cross-spectra between Planck data at 100, 143, 217, and 353 GHz, we examine the correlation of the dust polarization maps across frequency. We find no evidence for a loss of correlation and provide lower limits to the correlation ratio that are tighter than values we derive from the correlation of the 217- and 353 GHz maps alone. If the Planck limit on decorrelation for the largest sky region applies to the smaller sky regions observed by sub-orbital experiments, then frequency decorrelation of dust polarization might not be a problem for CMB experiments aiming at a primordial B-mode detection limit on the tensor-to-scalar ratio r similar or equal to 0.01 at the recombination peak. However, the Planck sensitivity precludes identifying how difficult the component-separation problem will be for more ambitious experiments targeting lower limits on r.
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| 3. |
- Andersson, Urban, et al.
(författare)
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Författaridentifikatorer och publiceringsdatabaser – scenarier och utvecklingsmöjligheter : slutrapport
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med projektet är att ge underlag för att införa författaridentifikatorer i svenska tjänster och system inom vetenskaplig kommunikation. ORCID (Open Researcher and Contributor ID) är en internationell de-facto standard under uppbyggnad med många viktiga aktörer involverade. Implementering av ORCID kräver samverkan mellan flera aktörer, både nationellt och på lärosätena.
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| 4. |
- Andersson, Urban, 1965, et al.
(författare)
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Författaridentifikatorer och publiceringsdatabaser – scenarier och utvecklingsmöjligheter
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med projektet är att ge underlag för att införa författaridentifikatorer i svenska tjänster och system inom vetenskaplig kommunikation. ORCID (Open Researcher and Contributor ID) är en internationell de-facto standard under uppbyggnad med många viktiga aktörer involverade. Implementering av ORCID kräver samverkan mellan flera aktörer, både nationellt och på lärosätena. Projektgruppen lämnar ett antal rekommendationer baserade på de uppgifter som redovisas i rapporten.
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| 5. |
- Gyllenberg, A, et al.
(författare)
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Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes
- 2012
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Ingår i: Genes and Immunity. - Stockholm : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 76:2, s. 202-203
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Tidskriftsartikel (refereegranskat)abstract
- The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to celiac disease at genome-wide level. However, attempts to replicate association have been inconclusive. Previously, we have observed linkage to the CIITA region in Scandinavian type 1 diabetes (T1D) families. Here we analyze five Swedish T1D cohorts and a combined control material from previous studies of CIITA. We investigate how the genotype distribution within the CIITA gene varies depending on age, and the association to T1D. Unexpectedly, we find a significant difference in the genotype distribution for markers in CIITA (rs11074932, P=4 × 10(-5) and rs3087456, P=0.05) with respect to age, in the collected control material. This observation is replicated in an independent cohort material of about 2000 individuals (P=0.006, P=0.007). We also detect association to T1D for both markers, rs11074932 (P=0.004) and rs3087456 (P=0.001), after adjusting for age at sampling. The association remains independent of the adjacent T1D risk gene CLEC16A. Our results indicate an age-dependent variation in CIITA allele frequencies, a finding of relevance for the contrasting outcomes of previously published association studies.
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| 6. |
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| 7. |
- Hansen, Tomas, et al.
(författare)
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Normal radiological lymph node appearance in the thorax
- 2019
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Ingår i: Diseases of the esophagus. - : OXFORD UNIV PRESS INC. - 1120-8694 .- 1442-2050. ; 32:10, s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- Modern treatment of esophageal cancer is multimodal and highly dependent on a detailed diagnostic assessment of clinical stage, which includes nodal stage. Clinical appraisal of nodal stage is highly dependent on knowledge of normal radiological appearance, information of which is scarce. We aimed to describe lymph node appearance on computed tomography (CT) investigations in a randomly selected cohort of healthy subjects. In a sample of the Swedish Cardiopulmonary bioimage study, which investigates a sample of the Swedish population aged 50-64 years, the CT scans of 426 subjects were studied in detail concerning intrathoracic node stations relevant in clinical staging of esophageal cancer. With stratification for sex, the short axis of visible lymph nodes was measured and the distribution of lymph node sizes was calculated as well as proportion of patients with visible nodes above 5 and 10 millimeters for each station. Probability of having any lymph node station above 5 and 10 millimeters was calculated with a logistic regression model adjusted for age and sex. In the 214 men (aged: 57.3 +/- 4.1 years) and 212 women (aged: 57.8 +/- 4.4 years) included in this study, a total of 309 (72.5%) had a lymph node with a short axis of 5 mm or above was seen in at least one of the node stations investigated. When using 10 mm as a cutoff, nodes were visible in 29 (6.81%) of the subjects. Men had higher odds of having any lymph node with short axis 5 mm or above (OR 3.03 95% CI 1.89-4.85, P < 0.001) as well as 10 mm or above (OR 2.31 95% CI 1.02-5.23, P = 0.044) compared to women. Higher age was not associated with propensity for lymph nodes above 5 or 10 millimeters in this sample. We conclude that, in a randomly selected cohort of patients between 50 and 64 years, almost 10% of the men and 4% of the women had lymph nodes above 10 millimeters, most frequently in the subcarinal station (station 107). More than half of the patients had nodes above 5 millimeters on CT and men were much more prone to have this finding. The probability of finding lymph nodes in specific stations relevant of esophageal cancer is now described.
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| 8. |
- Jernberg, Tomas, et al.
(författare)
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Impact of ischaemic heart disease severity and age on risk of cardiovascular outcome in diabetes patients in Sweden : A nationwide observational study
- 2019
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 9:4
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Tidskriftsartikel (refereegranskat)abstract
- Objectives To compare short-term cardiovascular (CV) outcome in type 2 diabetes (T2D) patients without ischaemic heart disease (IHD), with IHD but no prior myocardial infarction (MI), and those with prior MI; and assess the impact on risk of age when initiating first-time glucose-lowering drug (GLD). Design Cohort study linking morbidity, mortality and medication data from Swedish national registries. Participants First-time users of GLD during 2007-2016. Outcomes Predicted cumulative incidence for the CV outcome (MI, stroke and CV mortality) was estimated. A Cox model was developed where age at GLD start and CV risk was modelled. Results 260 070 first-time GLD users were included, 221 226 (85%) had no IHD, 16 294 (6%) had stable IHD-prior MI and 22 550 (9%) had IHD+MI. T2D patients without IHD had a lower risk of CV outcome compared with the IHD populations (±prior MI), (3-year incidence 4.78% vs 5.85% and 8.04%). The difference in CV outcome was primarily driven by a relative greater MI risk among the IHD patients. For T2D patients without IHD, an almost linear association between age at start of GLD and relative risk was observed, whereas in IHD patients, the younger (<60 years) patients had a relative greater risk compared with older patients. Conclusions T2D patients without IHD had a lower risk of the CV outcome compared with the T2D populations with IHD, primarily driven by a greater risk of MI. For T2D patients without IHD, an almost linear association between age at start of GLD and relative risk was observed, whereas in IHD patients, the younger patients had a relative greater risk compared with older patients. Our findings suggest that intense risk prevention should be the key strategy in the management of T2D patients, especially for younger patients.
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| 9. |
- Johansson, Åsa, et al.
(författare)
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Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome
- 2016
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 25:7, s. 1447-1456
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Tidskriftsartikel (refereegranskat)abstract
- N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a strong predictor of mortality in coronary artery disease and is widely employed as a prognostic biomarker. However, a causal relationship between NT-proBNP and clinical endpoints has not been established. We have performed a genome-wide association and Mendelian randomization study of NT-proBNP. We used a discovery set of 3740 patients from the PLATelet inhibition and patient Outcomes (PLATO) trial, which enrolled 18 624 patients with acute coronary syndrome (ACS). A further set of 5492 patients, from the same trial, was used for replication. Genetic variants at two novel loci (SLC39A8 and POC1B/GALNT4) were associated with NT-proBNP levels and replicated together with the previously known NPPB locus. The most significant SNP (rs198389, pooled P = 1.07 x 10(-15)) in NPPB interrupts an E-box consensus motif in the gene promoter. The association in SLC39A8 is driven by a deleterious variant (rs13107325, pooled P = 5.99 x 10(-10)), whereas the most significant SNP in POC1B/GALNT4 (rs11105306, pooled P = 1.02 x 10(-16)) is intronic. The SLC39A8 SNP was associated with higher risk of cardiovascular (CV) death (HR = 1.39, 95% CI: 1.08-1.79, P = 0.0095), but the other loci were not associated with clinical endpoints. We have identified two novel loci to be associated with NT-proBNP in patients with ACS. Only the SLC39A8 variant, but not the NPPB variant, was associated with a clinical endpoint. Due to pleotropic effects of SLC39A8, these results do not suggest that NT-proBNP levels have a direct effect on mortality in ACS patients. PLATO Clinical Trial Registration: ; NCT00391872.
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| 10. |
- Lexén, Jenny, et al.
(författare)
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ProScale - A life cycle oriented method to assess toxicological potentials of product systems (2017) : Guidance Document version 1.5
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The ProScale method was developed in an industrial consortium with expertise both from the Life Cycle Assessment and Risk Assessment areas. ProScale is intended as an easy-to-use and widely applicable method that can cover both human and eco-toxicity aspects. Currently available in this report is a module for assessing direct exposure related Human Toxicity Potentials in a life cycle perspective compatible with Life Cycle Assessments including Product Environmental Footprint (PEF).The ProScale methodology is based on chemical hazard described by substance classification (H-phrases) in the GHS/CLP classification system, occupational exposure limits (OEL) or Derived No Effect Levels (DNEL), and an exposure dose based on ECETOC Tiered Risk Assessment (TRA). ProScale scores are derived separately for inhalative, oral and dermal exposure routes. The document provides scientific background as well as practical guidance to the practitioner to carry out a ProScale assessment.
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| 11. |
- Lindholm, Daniel, et al.
(författare)
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Combined association of key risk factors on ischaemic outcomes and bleeding in patients with myocardial infarction
- 2019
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Ingår i: Heart. - : BMJ PUBLISHING GROUP. - 1355-6037 .- 1468-201X. ; 105:15, s. 1175-1181
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Tidskriftsartikel (refereegranskat)abstract
- Objective: In patients with myocardial infarction (MI), risk factors for bleeding and ischaemic events tend to overlap, but the combined effects of these factors have scarcely been studied in contemporary real-world settings. We aimed to assess the combined associations of established risk factors using nationwide registries.Methods: Using the Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry, patients with invasively managed MI in 2006-2014 were included. Six factors were assessed in relation to cardiovascular death (CVD)/MI/stroke, and major bleeding: age >= 65, chronic kidney disease, diabetes, multivessel disease, prior bleeding and prior MI.Results: We studied 100 879 patients, of whom 20 831 (20.6%) experienced CVD/MI/stroke and 5939 (5.9%) major bleeding, during 3.6 years median follow-up. In adjusted Cox models, all factors were associated with CVD/MI/stroke, and all but prior MI were associated with major bleeding. The majority (53.5%) had >= 2 risk factors. With each added risk factor, there was a marked but gradual increase in incidence of the CVD/MI/stroke. This was seen also for major bleeding, but to a lesser extent, largely driven by prior bleeding as the strongest risk factor.Conclusions: The majority of patients with MI had two or more established risk factors. Increasing number of risk factors was associated with higher rate of ischaemic events. When excluding patients with prior major bleeding, bleeding incidence rate increased only minimally with increasing number of risk factors. The high ischaemic risk in those with multiple risk factors highlights an unmet need for additional preventive measures.
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| 12. |
- Lindholm, Tomas, et al.
(författare)
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Expression of Semaphorins, Neuropilins, VEGF, and Tenascins in Rat and Human Primary Sensory Neurons after a Dorsal Root Injury
- 2017
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Ingår i: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Dorsal root injury is a situation not expected to be followed by a strong regenerative growth, or growth of the injured axon into the central nervous system of the spinal cord, if the central axon of the dorsal root is injured but of strong regeneration if subjected to injury to the peripherally projecting axons. The clinical consequence of axonal injury is loss of sensation and may also lead to neuropathic pain. In this study, we have used in situ hybridization to examine the distribution of mRNAs for the neural guidance molecules semaphorin 3A (SEMA3A), semaphorin 3F (SEMA3F), and semaphorin 4F (SEMA4F), their receptors neuropilin 1 (NP1) and neuropilin 2 (NP2) but also for the neuropilin ligand vascular endothelial growth factor (VEGF) and Tenascin J1, an extracellular matrix molecule involved in axonal guidance, in rat dorsal root ganglia (DRG) after a unilateral dorsal rhizotomy (DRT) or sciatic nerve transcetion (SNT). The studied survival times were 1-365 days. The different forms of mRNAs were unevenly distributed between the different size classes of sensory nerve cells. The results show that mRNA for SEMA3A was diminished after trauma to the sensory nerve roots in rats. The SEMA3A receptor NP1, and SEMA3F receptor NP2, was significantly upregulated in the DRG neurons after DRT and SNT. SEMA4F was upregulated after a SNT. The expression of mRNA for VEGF in DRG neurons after DRT showed a significant upregulation that was high even a year after the injuries. These data suggest a role for the semaphorins, neuropilins, VEGF, and J1 in the reactions after dorsal root lesions.
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| 13. |
- Lindholm, Tomas
(författare)
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On traumatic lesion to the spinal cord and dorsal spinal roots : factors influencing axonal regrowth across the border between the central and peripheral nervous system in the rat and man
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Nerve cells are depending on their environment. Glial cells, astrocytes and oligodendrocytes in the central nervous system (CNS) make up a totally different milieu and characteristics than the distinguishing qualities of the peripheral nervous system (PNS), where the nerve cells are surrounded by Schwann cells. The surrounding cells in the CNS and PNS give the tissues different reaction patterns following a nerve trauma situation. Traumatised axons in the PNS can most often be healed compared to the fact that this seldom is seen in the CNS. To enhance the understanding concerning the matter of the environment it could be of interest to thoroughly study the reaction after injury to the parts of the nervous system that has its course both in the CNS and in the PNS. To gain insight in how the adhesion modulating molecule tenascin might influence neuronal regeneration, the expression patterns of tenascin-R, tenascin-J1, tenascin-C and tenascin-X mRNA were analyzed in the perinatal adult rat spinal cord and olfactory system, as well as after a ventral funiculus lesion (VFL) of the spinal cord. All tenascin forms were up regulated in the scar tissue after VFL of the spinal cord. Thus tenascin expression in the adult primary olfactory pathway could not be correlated to tenascin expression in the scar tissue after spinal cord lesion. The data collected in this study showed that there was an early down-regulation of mRNAs for TN-R and J1 in the alpha-motoneurons in the ventral cord after a VFL. The data did also support a macroscopic up-regulation of macrophages in the ventral funiculus of the spinal cord. Our findings suggest that inflammatory cells invading the nerve tissue in the CNS may down-regulate TN mRNAs in axotomized motoneurons as a result of a persisting BBB dysfunction following a traumatic injury close to the motor nuclei. In order to gain further insight of the interplay between neuronally derived NRGs and Erb receptors we have examined the distribution of mRNA for NRG1, ErbB3 and ErbB4-receptor tyrosine kinases after a VFL, in two situations where growth of axons can occur across the CNS/PNS border. Regenerative sprouts from injured motor axons penetrate the CNS-type scar tissue and reach the supportive Schwann cells in the ventral root. The results in the present study indicated that NRG1 mRNA is constitutively expressed by adult spinal alfa-motoneurons. Our data show that ErbB3 in the ventral roots was upregulated after a VFL and that NRG1 mRNA was initially downregulated in the motoneurons. The lesion-induced changes in the expression of NRG l and ErbB3 in the injured spinal cord and denervated ventral root can be assumed to be of importance for axonal growth and the regulation of glial cell survival. To further elucidate the complex interactions between the action as a family of chemorepellents and/or chemoattracants, the semaphorins; Sema3A, SEMA3F, SEMA4F,and NP1, NP2 and VEGF mRNA, was analyzed after VFL as well as their expression in the ventral roots in adult rats. This study shows that an involvement of semaphorins and their receptors are involved in the posttraumatic response in spinal motoneurons after central axon injury. Though, the results suggest that the response in motoneuron expression of Sema3A and its receptor neuropilin 1 is dissimilar after lesions in the central and peripheral nervous systems. If the presence of VEGF, binding and blocking NP1, can have inhibiting effects on the chemorepulsive actions of Sema3A, it might imply a new incitament for VEGF as a positive molecule for nerve growth and regeneration. This study also shows that semaphorins and their receptors are involved in the posttraumatic response in rat and human dorsal root ganglia (DRG) neurons. The Sema3A receptor NP1, and SEMA3F receptor NP2, was significantly upregulated in the rat DRG neurons after dorsal rooot transection (DRT), sciatic nerve transection (SNT) and sciatic nerve crush (SNC). SEMA4F was upregulated after a SNT/SNC. The expression of mRNA for VEGF in rat DRG'S after DRT showed a significant upregulation that was high even a year after the injuries. These data suggest a significant role for the semaphorins, neuropilins, VEGF and J1 in the reactions after dorsal root lesions.
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| 14. |
- Olsson, Bertil, et al.
(författare)
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Förmaksflimmer - ny kunskap ger nya behandlingsmöjligheter
- 1999
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Ingår i: Läkartidningen. - 0023-7205. ; 96:36, s. 3796-3803
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation (AF) is the most common cardiac arrhythmia prompting treatment. Advances in our knowledge of the pathophysiology of AF provide the basis for new and improved treatment modalities. Thus, focal excitation and localised impulse conduction defects are possible trigger factors which can be counteracted by focal ablation and pacing synchronisation, respectively. Perpetuation of AF, caused by continuous multisite re-entry, is promoted by successive shortening of repolarisation. Internal defibrillation and anatomical limitation of re-entry are treatments that counteract perpetuation of the arrhythmia. Current knowledge of AF and the application of new treatments are discussed by the Lund AF research group.
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| 15. |
- Rydberg, Tomas, 1962, et al.
(författare)
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Environmental and socio-economic benefits of circularity in real estate management
- 2022
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Ingår i: E3S Web of Conferences. - : EDP Sciences. - 2555-0403 .- 2267-1242. ; 349
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Konferensbidrag (refereegranskat)abstract
- The environmental potential of reusing interior and building products (notably furniture, lighting, doors, windows, flooring and ceilings) has been calculated by a rather basic model based on life cycle approach. By making a calculation model available to housing and renovation companies in Sweden, a total of over 43000 items have been included in calculations as objects for reuse, stemming from about 130 renovation projects with a total waste saving of 800 tonnes of waste in the renovation stage. The first calculations of the corresponding avoided climate impact, from avoided waste management and avoided new product extraction and manufacturing, corresponds to around 1600 tonnes of CO2-equivalents. Translating this and other environmental aspects to monetary values with the EPS system, socioeconomic savings is around 2.3 million Euro. Assuming the same composition of items for potential reuse from all renovation activities in Sweden and extrapolating to the total annual amount of building waste, the potential annual savings on the national scale is estimated to be 900000 tons of building waste and 1.3 million tons of CO2 equivalents, corresponding to around 7% of the total annual greenhouse gas emissions of the Swedish building sector. With the EPS evaluation, the total annual environmental benefit adds up to 600 million Euro. The calculation model is currently being refined to include a better coverage of logistics and refurbishment activities.
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| 16. |
- Shev, Steven, et al.
(författare)
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Herpes simplex virus-2 may increase susceptibility of the sexual transmission of hepatitis C
- 1995
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Ingår i: Sexually Transmitted Diseases. - 1537-4521. ; 22:4, s. 210-216
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Antibodies against herpes simplex viruses-1 and -2, cytomegalovirus, and syphilis were determined in six heterosexual couples with strong indications of having sexually transmitted hepatitis C virus infection and in 17 other heterosexual couples in which one partner was hepatitis C virus viremic (source partner), but the other had remained hepatitis C virus uninfected (exposed partner). STUDY DESIGN. Antibody testing was done with an enzyme-linked immunosorbent assay. Anti-herpes simplex virus 2 and anti-hepatitis C virus findings were further confirmed by immunoblotting. Hepatitis C virus RNA was determined by polymerase chain reaction and genotyped with type-specific primers. RESULTS. Five of six anti-hepatitis C virus-positive exposed heterosexual partners without parenteral risk factors, compared with three of 17 anti-hepatitis C virus-negative exposed partners, had antibodies to herpes simplex virus-2. On the other hand, no statistically significant difference was found regarding the frequency of herpes simplex virus-2 seropositivity when source partners in the anti-hepatitis C virus concordant and discordant couples were compared. The presence of antibodies to herpes simplex virus-1, cytomegalovirus, and syphilis did not significantly differ between source or exposed partners in anti-hepatitis C virus concordant and discordant couples, respectively. No predominance of any one hepatitis C virus genotype or liver morphology in couples concordant compared with discordant for anti-hepatitis C virus was found. CONCLUSIONS. The findings support the role of herpes simplex virus-2 in the heterosexual transmission of hepatitis C virus infections, and more specifically an increase in susceptibility to hepatitis C virus infections in exposed heterosexual partners with antibodies to herpes simplex virus-2.
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| 17. |
- Xu, Hong, et al.
(författare)
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Outcomes associated to serum phosphate levels in patients with suspected acute coronary syndrome
- 2017
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Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We investigated the association between phosphate and the risk of adverse clinical outcomes in patients with manifest cardiovascular disease (CVD).METHODS: Observational study of patients hospitalized during 2006-2011 in Stockholm, Sweden, because of suspected acute coronary syndrome (ACS). The exposure was serum phosphate during the hospitalization. We modeled the association between phosphate and in-hospital death or in-hospital events (composite of myocardial infarction, cardiogenic shock, resuscitated cardiac arrest, atrial fibrillation, or atrioventricular block) as well as the one-year post-discharge risk of death or cardiovascular event (composite of myocardial re-infarction, heart failure and stroke). Confounders included demographics, comorbidities, kidney function, diagnoses, in-hospital procedures and therapies.RESULTS: Included were 2547 patients (68% men, mean age 67±14years) with median phosphate of 1.10 (range 0.14-4.20) mmol/L. During hospitalization, 198 patients died and 328 suffered an adverse event. Within one year post-discharge, further 381 deaths and 632 CVD events occurred. The associations of phosphate with mortality and CVD were J-shaped, with highest risk magnitudes at higher phosphate levels. For instance, compared to patients in the 50th percentile of phosphate distribution, those above the 75th percentile (1.3mmol/L, normal range) had significantly higher odds for in-hospital death [odds ratio 1.36, 95% confidence interval (CI) (1.08-1.71)] and of CVD post-discharge [sub-hazard ratios 1.17 (1.03-1.33)].CONCLUSIONS: In patients with suspected ACS, both higher and lower phosphate levels associated with increased risk of adverse outcomes during the index hospitalization and within one year post-discharge. The risk association was present already within normal-range serum phosphate values.
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