| 1. |
- Abbas, Muhammad, et al.
(författare)
-
Automated Reuse Recommendation of Product Line Assets Based on Natural Language Requirements
- 2020
-
Ingår i: Lecture Notes in Computer Science. - Cham : Springer Science and Business Media Deutschland GmbH. - 9783030646936 ; , s. 173-189, s. 173-189, s. 173-189
-
Konferensbidrag (refereegranskat)abstract
- Software product lines (SPLs) are based on reuse rationale to aid quick and quality delivery of complex products at scale. Deriving a new product from a product line requires reuse analysis to avoid redundancy and support a high degree of assets reuse. In this paper, we propose and evaluate automated support for recommending SPL assets that can be reused to realize new customer requirements. Using the existing customer requirements as input, the approach applies natural language processing and clustering to generate reuse recommendations for unseen customer requirements in new projects. The approach is evaluated both quantitatively and qualitatively in the railway industry. Results show that our approach can recommend reuse with 74% accuracy and 57.4% exact match. The evaluation further indicates that the recommendations are relevant to engineers and can support the product derivation and feasibility analysis phase of the projects. The results encourage further study on automated reuse analysis on other levels of abstractions.
|
|
| 2. |
- Abbas, Muhammad, et al.
(författare)
-
Product line adoption in industry : an experience report from the railway domain
- 2020
-
Ingår i: SPLC '20: Proceedings of the 24th ACM Conference on Systems and Software Product Line: Volume A. - New York, NY, USA : Association for Computing Machinery. - 9781450375696 ; , s. 130-141, s. 130-141
-
Konferensbidrag (refereegranskat)abstract
- The software system controlling a train is typically deployed on various hardware architectures and must process various signals across those deployments. The increase of such customization scenarios and the needed adherence of the software to various safety standards in different application domains has led to the adoption of product line engineering within the railway domain. This paper explores the current state-of-practice of software product line development within a team developing industrial embedded software for a train propulsion control system. Evidence is collected using a focus group session with several engineers and through inspection of archival data. We report several benefits and challenges experienced during product line adoption and deployment. Furthermore, we identify and discuss improvement opportunities, focusing mainly on product line evolution and test automation.
|
|
| 3. |
- Abdulla, Maysaa, et al.
(författare)
-
PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS
- 2021
-
Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 60:4, s. 531-538
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundProgrammed cell death 1 (PD-1) and its ligands PD-L1 and PD-L2, as well as Indoleamine 2,3-deoxygenase (IDO1) can be expressed both by tumor and microenvironmental cells and are crucial for tumor immune escape. We aimed to evaluate the role of PD-1, its ligands and IDO1 in a cohort of patients with primary diffuse large B-cell lymphoma of the CNS (PCNSL).Material and methodsTissue microarrays (TMAs) were constructed in 45 PCNSL cases. RNA extraction from whole tissue sections and RNA sequencing were successfully performed in 33 cases. Immunohistochemical stainings for PD-1, PD-L1/paired box protein 5 (PAX-5), PD-L2/PAX-5 and IDO1, and Epstein-Barr virus encoding RNA (EBER) in situ hybridization were analyzed.ResultsHigh proportions of PD-L1 and PD-L2 positive tumor cells were observed in 11% and 9% of cases, respectively. High proportions of PD-L1 and PD-L2 positive leukocytes were observed in 55% and 51% of cases, respectively. RNA sequencing revealed that gene expression of IDO1 was high in patients with high proportion of PD-L1 positive leukocytes (p = .01). Protein expression of IDO1 in leukocytes was detected in 14/45 cases, in 79% of these cases a high proportion of PD-L1 positive leukocytes was observed. Gene expression of IDO1 was high in EBER-positive cases (p = .0009) and protein expression of IDO1 was detected in five of six EBER-positive cases.ConclusionOur study shows a significant association between gene and protein expression of IDO1 and protein expression of PD-L1 in the tumor microenvironment of PCNSL, possibly of importance for prediction of response to immunotherapies.
|
|
| 4. |
- Gottwald, Janna M., et al.
(författare)
-
Infants prospectively control reaching based on the difficulty of future actions : To what extent can infants' multiple step actions be explained by Fitts' law?
- 2017
-
Ingår i: Developmental Psychology. - : American Psychological Association (APA). - 0012-1649 .- 1939-0599. ; 53:1, s. 4-12
-
Tidskriftsartikel (refereegranskat)abstract
- Prospective motor control, a key element of action planning, is the ability to adjust one's actions with respect to task demands and action goals in an anticipatory manner. The current study investigates whether 14-month-olds can prospectively control their reaching actions based on the difficulty of the subsequent action. We used a reach-to-place task, with difficulty of the placing action varied by goal size and goal distance. To target prospective motor control, we determined the kinematics of the prior reaching movements using a motion-tracking system. Peak velocity of the first movement unit of the reach served as indicator for prospective motor control. Both difficulty aspects (goal size and goal distance) affected prior reaching, suggesting that both these aspects of the subsequent action have an impact on the prior action. The smaller the goal size and the longer the distance to the goal, the slower infants were in the beginning of their reach toward the object. Additionally, we modeled movement times of both reaching and placing actions using a formulation of Fitts' law (as in heading). The model was significant for placement and reaching movement times. These findings suggest that 14-month-olds can plan their future actions and prospectively control their related movements with respect to future task difficulties.
|
|
| 5. |
- Lindskog, Claes E., et al.
(författare)
-
The Sky as Heterotopia in in Dickens, Gissing, and Woolf
- 2022
-
Ingår i: Re-Reading the Age of Innovation : Victorians, Moderns, and Literary Newness, 1830–1950 - Victorians, Moderns, and Literary Newness, 1830–1950. - New York : Routledge. - 9781003191629 - 9781032043593 ; , s. 23-35
-
Bokkapitel (refereegranskat)abstract
- Different aspects of the novel have changed at a different pace. If one compares modernist novels with those of a 100 years previously, not only is an inward turn noticeable but also an outward turn: the sky, for example, is much more present. This change does not, however, coincide with the Victorian-modernist divide but rather comes when the influence of romantic poetry reaches the novel. This chapter presents a statistical survey of mentionings of the sky in 240 representative British novels from the period 1719–1929. It also examines how Dickens’s Barnaby Rudge , Gissing’s Thyrza, and Woolf’s Mrs Dalloway in different ways use the sky to comment on the idea of the romantic. Together, these two parts demonstrate that in this respect, at least, the Victorian and the modernist novel have much more in common than either has with earlier novels.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Lindskog, Claes
(författare)
-
Spatial Structures in Conrad’s Universe : The Tension between Opening and Closing as a Literary Device
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Many attempts have been made to catch the essence of Joseph Conrad’s work by examining the contents of his ideas. This thesis argues instead that the important factor is the preferred spatial structures of his world-views and the interplay between them. Above all, Conrad’s work can be seen as a battle-ground between closing and opening structures. The former have a claustrophobic effect on the contemplating mind but are generally described by Conrad as having a greater truth-value. The latter give a sense of freedom and hope, but are also experienced as illusory and transient. In this context one should distinguish between an idea and the various attitudes that are taken towards it. An epistemological attitude, such as belief, concerns the truth value of an idea, while an axiological attitude is concerned with the value of an idea to a mind. This thesis contends that while Conrad’s basic ideas changed little during his writing career, the attitudes towards them vary greatly, partly in accordance with the literary needs of the text at hand. Chapter 1 presents a specific plot that recurs in many of Conrad’s works, including Heart of Darkness and Lord Jim. This plot describes a progression from a state of illusion to a new, claustrophobic, world-view that is valorised epistemologically as truth, but is also regarded as detrimental for an individual’s mental health. It is not possible to live with the new view and the individual is consequently forced to seek either a “saving dullness” or a new set of illusions. In chapter 2, the scanty descriptions of the horrifying new world-view are collated with Conrad’s descriptions of his own ideas in letters contemporary with the analysed texts. The famous Stein chapter in Lord Jim is singled out for special analysis in chapter 3, with specific focus on the opening techniques by which the closing of the world is challenged. For chapter 4 the focus shifts to an individual’s experience of a hopelessly claustrophobic life-situation and how the attempts to open this forms an important part of the plot in Under Western Eyes. In the last chapter, the opening possibilities of writing are considered, especially as regards the genre of romance which Conrad uses already in Lord Jim but especially towards the end of his career. By describing the necessity of romance, Conrad’s achieve the effect that they can be read as both romance and anti-romance, depending on the preferences of the reader.
|
|
| 9. |
- Lindskog, Claes
(författare)
-
The Spatial Experience of the Sky in Jane Eyre and Wuthering Heights
- 2020
-
Ingår i: Bronte Studies. - : Informa UK Limited. - 1474-8932 .- 1745-8226. ; 45:1, s. 63-70
-
Tidskriftsartikel (refereegranskat)abstract
- Discussions of the sky in the Brontës’ works have tended to limit themselves to the weather, making Jane Eyre and Wuthering Heights seem very similar to one another in this regard. If, however, attention instead turns to the sky as a spatial phenomenon, there is a considerable difference between the two novels, symptomatic of a greater difference in the possibility of personal freedom. Thus, while the sky represents a sense of liberation in both novels, in Jane Eyre it really provides a refuge for the mind and in Wuthering Heights it rather signals the impossibility of relief.
|
|
| 10. |
- Lindskog, Claes, et al.
(författare)
-
The Swedish Uses of Conrad
- 2022. - 1
-
Ingår i: The Reception of Joseph Conrad in Europe. - 9781474241083 - 9781474241113 - 9781474241106 ; , s. 363-380
-
Bokkapitel (refereegranskat)
|
|
| 11. |
- Selvin, Tove, et al.
(författare)
-
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs : an in vitro assessment
- 2024
-
Ingår i: BMC Pharmacology & Toxicology. - : BioMed Central (BMC). - 2050-6511. ; 25:1
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundIt has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunological effects of 46 standard anticancer agents and 22 commonly administered concomitant non-cancer drugs.MethodsWe utilized a miniaturized in vitro model system comprised of fluorescently labeled human colon and lung cancer cell lines grown as monocultures and co-cultured with activated peripheral blood mononuclear cells (PBMCs). The Bliss Independence Model was then applied to detect antagonism and synergy between the drugs and activated immune cells.ResultsAmong the standard anticancer agents, tyrosine kinase inhibitors (TKIs) stood out as the top inducers of both antagonism and synergy. Ruxolitinib and dasatinib emerged as the most notably antagonistic substances, exhibiting the lowest Bliss scores, whereas sorafenib was shown to synergize with activated PBMCs. Most concomitant drugs did not induce neither antagonism nor synergy. However, the statins mevastatin and simvastatin were uniquely shown to synergize with activated PBMC at all tested drug concentrations in the colon cancer model.ConclusionWe utilized a miniaturized tumor-immune model to enable time and cost-effective evaluation of a broad panel of drugs in an immuno-oncology setting in vitro. Using this approach, immunomodulatory effects exerted by TKIs and statins were identified.
|
|
