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- Dantuma, NP, et al.
(författare)
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Stressing the ubiquitin-proteasome system
- 2010
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Ingår i: Cardiovascular research. - : Oxford University Press (OUP). - 1755-3245 .- 0008-6363. ; 85:2, s. 263-271
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Giwercman, YL, et al.
(författare)
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Response to treatment in patients with partial androgen insensitivity due to mutations in the DNA-binding domain of the androgen receptor
- 2000
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Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 53:2, s. 83-88
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Tidskriftsartikel (refereegranskat)abstract
- The androgen insensitivity syndrome is a disorder caused by deficient function of the androgen receptor, characterized by varying degrees of undermasculinization in karyotypic males. We have identified four mutations in the androgen receptor gene, in the region encoding the DNA-binding domain of the protein. Two mutations, R607X and R615G, were found in patients with complete insensitivity to androgens, whereas the other two, S578T and A596T, were found in patients with partial insensitivity. The functional consequences of the three missense mutations were assayed in vitro after transient expression of the receptors in COS cells. All mutants showed normal androgen binding but abnormal abilities to stimulate transcription of an androgen-responsive reporter gene. R615G abolished transactivation whereas S578T and A596T were partially malfunctional. The function of A596T, but not of S578T, was normalized at high androgen concentrations in vitro, reflecting the in vivo situation. Thus, patients with specific mutations in the DNA-binding domain of the androgen receptor may benefit from androgen treatment.
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- Lindsten, K, et al.
(författare)
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GFP reporter mouse models of UPS proteolytic function
- 2006
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Ingår i: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - : Wiley. - 1530-6860. ; 20:7, s. 1027-author
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 15. |
- Lindsten, K, et al.
(författare)
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GFP reporter mouse models of UPS proteolytic function
- 2006
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Ingår i: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - : Wiley. - 1530-6860. ; 20:7, s. 1027-1027
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Lindsten, K, et al.
(författare)
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Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
- 2002
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Ingår i: The Journal of cell biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 157:3, s. 417-427
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Tidskriftsartikel (refereegranskat)abstract
- Loss of neurons in neurodegenerative diseases is usually preceded by the accumulation of protein deposits that contain components of the ubiquitin/proteasome system. Affected neurons in Alzheimer's disease often accumulate UBB+1, a mutant ubiquitin carrying a 19–amino acid C-terminal extension generated by a transcriptional dinucleotide deletion. Here we show that UBB+1 is a potent inhibitor of ubiquitin-dependent proteolysis in neuronal cells, and that this inhibitory activity correlates with induction of cell cycle arrest. Surprisingly, UBB+1 is recognized as a ubiquitin fusion degradation (UFD) proteasome substrate and ubiquitinated at Lys29 and Lys48. Full blockade of proteolysis requires both ubiquitination sites. Moreover, the inhibitory effect was enhanced by the introduction of multiple UFD signals. Our findings suggest that the inhibitory activity of UBB+1 may be an important determinant of neurotoxicity and contribute to an environment that favors the accumulation of misfolded proteins.
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- Molina Gomez, Andrea, et al.
(författare)
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Emergency power flow re-routing in a distribution system by using dynamic line rating
- 2020
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Ingår i: 2020 International Conference on Probabilistic Methods Applied to Power Systems, PMAPS 2020 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc..
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Konferensbidrag (refereegranskat)abstract
- Dynamic rating is a technology which allows loading power lines above their rated limits. More often, dynamic rating is used to transport new power and connect additional generators to the grid using existing infrastructure. However, this study explores the possibility to use dynamic rating for improving the security of supply and assisting fast reconnection of disconnected customers during emergency and fault situations occurring at other lines. DLR allows improving power system reliability during emergency conditions using Optimal Power Flow (OPF), which additionally helps to minimize costs of system operation. Large costs involving investment for new infrastructure and penalties for interruptions in the power supply can be considerably reduced by implementing DLR. Also, DLR can improve the reliability of the system by providing real-Time information on the status of power lines. Using Optimal Power Flow ensures that the lines loading, bus voltage magnitudes and angles as well as generation injections are within the acceptable limits as per the utility regulations. Faults are modelled as cases when one of the lines becomes disconnected. The bottlenecks in the system during post-fault situations are identified to determine optimal lines in the system on which DLR could be implemented.
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- Zasčiurinskienė, Eglė, et al.
(författare)
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Orthodontic treatment in periodontitis-susceptible subjects: a systematic literature review
- 2016
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Ingår i: Clinical and Experimental Dental Research. - : Wiley. - 2057-4347. ; 2:2, s. 162-173
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Tidskriftsartikel (refereegranskat)abstract
- The aim is to evaluate the literature for clinical scientific data on possible effects of orthodontic treatment on periodontal status in periodontitis-susceptible subjects. A systematic literature review was performed on studies in English using PubMed, MEDLINE, and Cochrane Library central databases (1965-2014). By manually searching reference lists of selected studies, we identified additional articles; then we searched these publications: Journal of Periodontology, Periodontology 2000, Journal of Clinical Periodontology, American Journal of Orthodontics and Dentofacial Orthopedics, Angle Orthodontist, International Journal of Periodontics & Restorative Dentistry, and European Journal of Orthodontics. Search terms included randomized clinical trials, controlled clinical trials, prospective and retrospective clinical studies, case series > 5 patients, periodontitis, orthodontics, alveolar bone loss, tooth migration, tooth movement, orthodontic extrusion, and orthodontic intrusion. Only studies on orthodontic treatment in periodontally compromised dentitions were included. One randomized controlled clinical trial, one controlled clinical trial, and 12 clinical studies were included. No evidence currently exists from controlled studies and randomized controlled clinical trials, which shows that orthodontic treatment improves or aggravates the status of periodontally compromised dentitions.
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- Zasčiurinskienė, Eglė, et al.
(författare)
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Orthodontic treatment simultaneous to or after periodontal cause-related treatment in periodontitis susceptible patients. Part I: Clinical outcome. A randomized clinical trial
- 2018
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Ingår i: Journal of Clinical Periodontology. - : Wiley. - 0303-6979 .- 1600-051X. ; 45:2, s. 213-224
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Tidskriftsartikel (refereegranskat)abstract
- AimTo compare two treatment strategies regarding the effect of orthodontic treatment on periodontal status in patients with plaque-induced periodontitis. Subjects and MethodsThis was a randomized clinical trial. Fifty periodontal patients were randomly assigned to the test or control groups according to periodontal treatment timing. All patients received supra- and subgingival debridement following baseline examination. Control group patients received cause-related periodontal treatment before the start of orthodontic treatment and which was performed simultaneous to orthodontic treatment for the test group patients. ResultsNo difference between the test and control groups was found regarding change of clinical attachment level (CAL) after periodontal-orthodontic treatment. Fewer sites with initial pocket depth (PD) of 4-6mm healed after periodontal-orthodontic treatment in the test group (20.5%, IQR=11.9%) in comparison with controls (30.4%, IQR=27.1%) (p=.03). Anterior teeth [OR 2.5] and teeth in male patients [OR 1.6] had a greater chance for PD improvement 2mm. Total periodontal-orthodontic treatment duration was significantly longer for the control group (p<.01). ConclusionsBoth groups showed a gain of CAL and a reduction in sites with PD 4mm. Orthodontic treatment, simultaneously to the periodontal treatment, could be used in the routine treatment of patients with plaque-induced periodontitis.
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