| 1. |
- Berg, Elisabeth Gräslund, et al.
(författare)
-
Praktiker som gör skillnad : Om den verb-inriktade metoden
- 2013
-
Ingår i: Historisk Tidskrift. - 0345-469X .- 2002-4827. ; 133:3, s. 335-354
-
Tidskriftsartikel (refereegranskat)abstract
- This article discusses the so-called verb-oriented method and its role in the research project Gender and Work in early modern Sweden (GaW), which is based at Uppsala University. It provides a presentation of the GaW-database, which has been designed to allow analysis according to the verb-method. Finally, the article points out that this method can be combined with a number of different theoretical approaches as long as the focus is on practices. It is therefore compatible with the approaches of e.g., Judith Butler, Michel de Certeau, and Amartya Sen. Work is defined as "time-use with the purpose of making a living" and the article discusses why data on time-use, or actual work activities, are better suited for research into early modern Swedish working life than other types of data. It shows that activities are usually described in the sources by verb-phrases, and explains how and from what sources verb-phrases are collected and analyzed within the project. In order to allow for generalizations the verb-method presupposes large amounts of data. This is the rationale for the GaW-database, which at present includes around 5000 verb-phrases and 75000 data posts.
|
|
| 2. |
|
|
| 3. |
- Dahrén, Börje, fil.dr, 1984-, et al.
(författare)
-
Transformation or consolidation : Evaluating transformative agreements at Uppsala University with an eye to the future
- 2021
-
Konferensbidrag (refereegranskat)abstract
- In the last few years, we have seen how publishing agreements have become increasingly common across Europe. At Uppsala University, the traditional subscription agreements now represent a minority of our agreements with the publishers and we suspect they will be phased out. Currently, our most common type of publishing agreements are the transformative agreements negotiated on the national level by the Bibsam consortia and offered to all Swedish higher education institutions. These transformative agreements currently cover most major international publishers and could be considered the new normal.Uppsala University is one of the largest and oldest universities in northern Europe. We are a truly multidisciplinary university, covering the humanities, social sciences, medicine, science and technology. This means that the university library should ideally be able to provide the same level of publishing support for theologists as well as geologists. With that in mind, the library was tasked to evaluate our portfolio of publishing agreements, with a special focus on the impact of the transformative ones. We wanted specifically to look at these new agreements in regards to 1) the impact for the individual researchers 2) economic aspects on various levels, and 3) the paradigm shift towards open science that is taking place in scholarly communication.–We have identified a few key effects and aspects of the transformative agreements:• They remove thresholds and provide a smooth transition to OA publishing• They are arguably very expensive. Are these just the latest iteration of the “Big Deals”?• The coverage is not equal for all parts of the university. Great coverage for STEM, not so much for the arts and humanities.• Other publishing actors are unfairly and disproportionally disadvantaged. Non-commercial OA publishers, diamond OA and small scale society publishing lose much of their advantage on the already dysfunctional publishing market.–What to do next?• A local strategy for publishing agreements is needed to complement what is provided by national consortia.• Libraries should divert more energy towards support for DIY publishing and other researcher-led initiatives.• The time for OA advocacy is in the past. It is time for global and holistic open science perspectives.In conclusion, our view is that transformative agreements are highly useful for us at this point in time, but need to be managed and complemented. It is essential that we keep monitoring the costs, provide alternatives and develop our services portfolio. Above all, we need to recognise that these agreements are a stepping stone on the path towards open science. They are, however, not the final solution.
|
|
| 4. |
- Herbertsson, Lina, et al.
(författare)
-
Bees increase seed set of wild plants while the proportion of arable land has a variable effect on pollination in European agricultural landscapes
- 2021
-
Ingår i: Plant Ecology and Evolution. - : Societe Royale de Botanique de Belgique. - 2032-3913 .- 2032-3921. ; 154:3, s. 341-350
-
Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Agricultural intensification and loss of farmland heterogeneity have contributed to population declines of wild bees and other pollinators, which may have caused subsequent declines in insect-pollinated wild plants.Material and methods: Using data from 37 studies on 22 pollinator-dependent wild plant species across Europe, we investigated whether flower visitation and seed set of insect-pollinated plants decline with an increasing proportion of arable land within 1 km.Key results: Seed set increased with increasing flower visitation by bees, most of which were wild bees, but not with increasing flower visitation by other insects. Increasing proportion of arable land had a strongly variable effect on seed set and flower visitation by bees across studies.Conclusion:Factors such as landscape configuration, local habitat quality, and temporally changing resource availability (e.g. due to mass-flowering crops or honey bee hives) could have modified the effect of arable land on pollination. While our results highlight that the persistence of wild bees is crucial to maintain plant diversity, we also show that pollen limitation due to declining bee populations in homogenized agricultural landscapes is not a universal driver causing parallel losses of bees and insect-pollinated plants.
|
|
| 5. |
- Ivarsson, Lina Birgitta, et al.
(författare)
-
Treatment of Urethral Pain Syndrome (UPS) in Sweden
- 2019
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:11
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Urethral Pain Syndrome (UPS) in women is a recurrent urethral pain without any proven infection or other obvious pathology. There are few studies on UPS, and evidence-based treatment is lacking. The primary aim was to study what treatments are used, and to compare the treatment tradition of UPS in Sweden in 2018, with what was used in 2006.METHODS: A questionnaire on the treatment of women with UPS was sent to all public gynecology, urology, gynecologic oncology and venereology clinics, and one public general practice in each county in Sweden in 2018. Private practice clinics in gynecology responded to the survey in 2017. Comparisons were made with the same survey sent to gynecology and urology clinics in 2006.FINDINGS: Of 137 invited clinics in 2018, 99 (72.3%) responded to the survey. Seventy-seven (77.8%) of them saw women with UPS and 79.2% (61/77) of these clinics treated the patients using 19 different treatment methods. Local corticosteroids and local estrogens were the methods most used. Treatments were similar in gynecology and urology clinics in 2006 and 2018, although strong corticosteroids had increased in use in the treatment regimens of 2018. More than half of the clinics used antibiotics.INTERPRETATION: Since there is no evidence-based treatment of UPS, a wide spectrum of treatments is used, and different specialties use different treatment strategies. Despite the lack of proven infection, a large number of clinics also treated the syndrome with antibiotics. There is thus a need for well-designed randomized controlled clinical trials to find evidence-based treatments of UPS.
|
|
| 6. |
- Lind, Erik, et al.
(författare)
-
A resonant tunneling permeable base transistor with Al-free tunneling barriers
- 2002
-
Ingår i: Device Research Conference (Cat. No.02TH8606). - 0780373170 ; , s. 155-156
-
Konferensbidrag (refereegranskat)abstract
- Summary form only given. Resonant tunneling based devices are an intriguing set of devices with promising high speed, low power and high functionality capabilities. We have developed an technology to embed metallic features on the nm-scale inside a semiconductor. By combining such metallic features and heterostructures we have developed a new type of tunneling transistor, the so called Resonant Tunneling Permeable Base Transistor (RT-PBT), where a double barrier heterostructure is placed in close vicinity to a metal grating. A three step fabrication process is described
|
|
| 7. |
- Lind, Erik, et al.
(författare)
-
Resonant tunneling permeable base transistor based pulsed oscillator
- 2004
-
Ingår i: Device Research Conference - Conference Digest, DRC. - 1548-3770. ; , s. 129-130
-
Konferensbidrag (refereegranskat)abstract
- A technology was developed to embed nm-sized metallic features in close vicinity to semiconductor heterostructures, which allows a direct integration of resonant tunneling diodes (RTD) inside the channel of permeable base transistor. A AlGaAs/InGaAs based RTD was grown by molecular beam epitaxy (MBE), with peak current density either 70 or 120 kA/cm2. A fundamental oscillation frequency of 800 MHz was detected, with higher harmonics up to 2.6 GHz, using a spectrum analyzer. It was found that the oscillations could be quenched by applying a large (-1.5V) negative gate bias. The results indicate that a three terminal resonant tunneling transistor can be used to obtain pulsed operation of a resonant tunneling based oscillator.
|
|
| 8. |
- Lind, Erik, et al.
(författare)
-
Resonant Tunneling Permeable Base Transistor for RF applications
- 2003
-
Ingår i: 2003 International Semiconductor Device Research Symposium (IEEE Cat. No.03EX741). - 0780381394 ; , s. 487-488
-
Konferensbidrag (refereegranskat)abstract
- A technique is developed to embed tungsten inside semiconductors, with the possibility to combine the metallic elements and semiconductor heterostructure with nm-precision. This technique enables to fabricate a very high quality permeable base type of transistor. A resonant tunneling permeable base transistor, RT-PBT is fabricated by directly integrating a tungsten grating 30 nm above a pseudomorphic RTD. Double barrier heterostructure (AlGaAs/InGaAs) is grown by molecular beam epitaxy and the wafer is patterned by e-beam lithography to form the grating. Common collector current-voltage characteristics were measured at room temperature
|
|
| 9. |
- Lind, Erik, et al.
(författare)
-
Resonant tunneling permeable base transistors with high transconductance
- 2004
-
Ingår i: IEEE Electron Device Letters. - 0741-3106. ; 25:10, s. 678-680
-
Tidskriftsartikel (refereegranskat)abstract
- A GaAs-based resonant tunneling permeable base transistor has been developed and evaluated at room temperature. The transistor is fabricated by overgrowing a tungsten gate placed next to an AlGaAs-GaAs-InGaAs resonant tunneling heterostructure. By changing the gate voltage, the effective conducting area of the tunnel diode can be modulated and the collector-emitter current thus controlled. Peak currents above 300 mA/mm and a maximum transconductance of 270 mS/mm have been obtained.
|
|
| 10. |
- Lind, Erik, et al.
(författare)
-
Stacking of heterostructures and metallic elements for a submicron resonant tunneling transistor
- 2002
-
Ingår i: 7th International Conference on Nanometer-Scale Science and Technology and 21st European Conference on Surface Science.
-
Konferensbidrag (refereegranskat)abstract
- We have successfully embedded a metal gate in-between two resonant tunneling double barrier heterostructures (RTD), thus realizing a three dimensional resonant tunneling transistor. The gate is placed 30 nm above and 100 below the two RTD's, respectively. The asymmetric gate allows for a unique control of the current-voltage characteristics, not only controlling the peak current but also the peak voltage. We have modeled the transistor with Cadence, a standard simulation package for circuit simulations, achieving good agreement with experimental data
|
|
| 11. |
- Lind, Erik, et al.
(författare)
-
Three-dimensional integrated resonant tunneling transistor with multiple peaks
- 2002
-
Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 81:10, s. 1905-1907
-
Tidskriftsartikel (refereegranskat)abstract
- A resonant tunneling transistor was manufactured by integrating a self-aligned metallic gate 30 nm above and 100 nm below resonant tunneling diodes. The Schottky depletion around the gate controls the current to a confined vertical channel with a conduction area in the range of 100x100 nm. Due to the three-dimensional asymmetric placement of the gate with respect to the tunneling diodes, modulation of both the peak voltage and peak current was achieved.
|
|
| 12. |
|
|
| 13. |
- Lindström, Peter, et al.
(författare)
-
Design of resonant tunneling permeable base transistors
- 2004
-
Ingår i: 2003 International Symposium on Compound Semiconductors: Post-Conference Proceedings (IEEE Cat. No.03TH8767). - 0780386140 ; , s. 158-163
-
Konferensbidrag (refereegranskat)abstract
- We evaluate the performance of resonant tunneling permeable base transistors (RT-PBTs) by numerical simulations. Since the current is limited by the barriers, a design with a low doping level around the embedded gate wires is chosen to improve the transconductance. We evaluate the influence of the various geometrical parameters, to optimize the design for high frequency operation. We obtain a performance comparable to conventional PBTs, to which we have incorporated the tunneling characteristics
|
|
| 14. |
- Moberg, Christina, et al.
(författare)
-
De unga gör helt rätt när de stämmer staten
- 2022
-
Ingår i: Aftonbladet. - 1103-9000.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
|
|
| 15. |
- Nilsson, Sara, 1990-
(författare)
-
How requirements development could support design of effective and resource-efficient offerings
- 2017
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- What a company offers its customers has to fulfil several different needs, desires, constraints, which can originate from multiple different sources that affect the offering throughout its life cycle. All these criteria have to come together and be translated into statements that can support the designer’s understanding of the offering’s purpose. This translation is done through a requirements development process to provide a controlled process to define statements that describe what the offering is supposed to fulfil.This research provides insights on key challenges and success factors in requirements development to support the design of effective and resource-efficient offerings. Namely, it identifies crucial sources and aspects to be considered, and a requirements development process demonstrating how to overcome identified challenges. By getting the requirements right from the beginning, sub-optimisation and unnecessary time and risks can be avoided. The consideration of accurate sources and aspects is considered to be one of the most important factors for the successful design of offerings. It is also in the earliest phases of design, that is to say requirements development, where one has the greatest possibility to affect the environmental impact of the offering. What is missing, however, is sufficient and appropriate support in industry on how to do so.The gap between the three areas of effectiveness and resource efficiency, design of integrated offerings, and requirements development has been investigated. Results are based on findings in the literature and in industry, identified primarily by qualitative studies. In the research, 15 different companies have been included through a number of interviews and discussions.Key sources and aspects to consider in the requirements development process are identified along with challenges, and success factors that can be utilised to overcome the identified challenges. This research’s final results include an adapted requirements development process that considers the earlier-mentioned sources and aspect, challenges, and success factors. Such a requirements development process should support the design of effective and resource-efficient offerings.
|
|
| 16. |
- Smith, Henrik G., et al.
(författare)
-
Slututvärdering av det svenska landsbygdsprogrammet 2007–2013 : Delrapport II: Utvärdering av åtgärder för bättre miljö
- 2016
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- SammanfattningRapporten är en del av slututvärderingen av Landsbygdsprogram för Sverige 2007-2013 och har tagits fram på uppdrag av Jordbruksverket. Den redovisar resultat och effekter som uppnåddes genom miljö- och klimatåtgärderna inom landsbygdsprogrammet, vilket omfattar samtliga insatser och ersättningar i axel 2, samt miljö- och klimatrelaterade utvärderingsfrågor för en del åtgärder i axel 1 och 3.Med hjälp av vetenskapliga analyser, kunskapsbaserade resonemang och de för varje insats i landsbygdsprogrammet specificerade indikatorerna har bland annat följande EU-gemensamma (QEC) och programspecifika (PSEQ) utvärderingsfrågor besvarats:• QEC 16: I vilken utsträckning har åtgärden bidragit till att förbättra miljösituationen?• CEQ 20: Vilka andra effekter, bl.a. de som rör andra mål/axlar, är kopplade tillgenomförandet av denna åtgärd?• PSEQ 16A: Hur ändamålsenlig och effektiv har den geografiska styrningen avmiljöåtgärden i programmet varit?• PSEQ 20A: I vilken utsträckning har kompetensutvecklingsåtgärderna bidragittill programmets miljömål?• PSEQ 20B: Vad kan man lära sig av hur klimatåtgärderna fungerat när det gällerutformningen och utvärderingen av klimatåtgärder i framtida program?• PSEQ 20C: Vilka sysselsättningseffekter ger miljöåtgärderna?Utredarnas generella slutsats är att landsbygdsprogrammet spelat en stor och i många fall avgörande roll för miljön, t.ex. genom att förhindra nedläggning av jordbruk i områden med svåra förutsättningar för jordbruk, bevara betes- och slåttermarker av värde för biologisk mångfald och skapa och restaurera våtmarker för biologisk mångfald och näringsretention. Detta bidrar till uppfyllelsen av de svenska miljömålen och internationella åtaganden. Även de klimatrelaterade åtgärderna bidrar i viss mån till att uppfylla miljömålen, men en låg anslutning till vissa åtgärder och programmets ensidiga fokus på produktion av förnybar energi (som bortser från ur klimatsynvinkel mycket större biogena utsläppskällor) gör att effekten på miljömålen bedöms som relativt små. Bedömningen av kompetensutvecklingens effekter på miljömålen har försvårats av brist på tillämpningsbart underlag, men utvärderingen av rådgivningsprogrammet Greppa näringen visar att det bidragit till att reducerakvävetillförseln till Östersjön. För en del andra åtgärder är det empiriska underlaget för vilken effekt de har mycket svagt. Detta behöver i sig inte innebära att dessa åtgärder saknar effekt, men gör det svårt att bedöma deras bidrag till uppfyllelsen av miljömålen och begränsar kunskapen om huruvida alternativa utformningar av insatserna skulle ge större effekt.Den explicita geografiska styrningen som förekommer i programmet bedöms generellt som relevant, men dess effekt varierar stort mellan olika åtgärder/insatser och är i vissa fall svårt att utreda. Det finns dock en del åtgärder/insatser som idag saknar explicit geografisk styrning, men där vi bedömer att kostnadseffektiviteten skulle kunna öka markant om man införde en sådan (t.ex. Certifierad ekologisk produktion).Miljöåtgärdernas sysselsättningseffekter har endast kunnat bedömas för ett fåtalåtgärder/insatser (kompensationsbidraget samt ersättningarna för Extensiv vallodling och Skötsel av betesmarker och slåtterängar) och anses generellt vara marginellt positiv. Detta bör dock tolkas med stor försiktighet eftersom bedömningen gjordes enbart via dessa åtgärders effekt på markanvändningen.Miljö- och klimatåtgärders effekterUnder programperioden 2007-2013 innehöll landsbygdsprogrammet en mängd olika åtgärder med syfte att gynna miljö och klimat. Utvärderingen visar att det finns en stor variation i såväl upptaget av de olika åtgärderna som deras effekt. Miljöåtgärdernas syften fokuserar huvudsakligen på att gynna bevarandet av biologisk mångfald, minskat växtnäringsläckage och giftfri miljö. De flesta miljöåtgärder bidrar generellt till att uppnå sitt syfte, men om de gör det på ett kostnadseffektivt sätt har ofta varit svårt och ibland omöjligt att utvärdera. För syftet giftfri miljö har det inte funnits resurser till en djupare utvärdering.Ersättningarna för Skötsel av betesmarker och slåtterängar samt för Certifieradekologisk och kretsloppsinriktad produktion är exempel på insatser med konstaterad positiv effekt på biologisk mångfald. Andra ersättningar, såsom ersättningen för Värdefulla natur- och kulturmiljöer, adresserar visserligen för biologisk mångfald viktiga livsmiljöer, men deras utformning och skötselvillkor har visat sig inte vara anpassade till detta syfte med insatsen. För en del ersättningar saknas tillräckligt kunskap eller dataunderlag för att kunna göra tillfredställande utvärderingar av effekterna på biologisk mångfald. Bland dessa finns exempelvis ersättningarna för Extensiv vallodling och Skötsel av våtmarker.Minskat näringsämnesläckage och miljömålet Ingen övergödning fanns som syfte för flera insatser inom åtgärden Miljövänligt jordbruk och den generella bedömningen är att insatserna bidrar till att uppfylla detta syfte. Det finns dock stor skillnad i hur effektiva insatserna är. Minskat kväveläckage anses ha en god kostnadseffektivitet, särskilt efter att ersättningsnivåerna anpassades under senare delen av programperioden. Även reduceringen av fosfor genom skyddszoner bedöms ha en högre kostnadseffektivitet jämfört med förra programperioden på grund av regionala skillnader i anslutning. När det gäller Extensiv vallodling visar utvärderingen stora regionala skillnader, och för andra insatser, såsom Restaurering och anläggning av våtmarker och Certifierad ekologisk odling, har det varit svårt att bedöma om de på ett kostnadseffektivt sätt bidragit till att uppfylla miljömålen.Miljöåtgärdernas effekter på miljömålet Giftfri miljö har inom ramen för dennautvärdering inte kunnat analyseras specifikt på grund av bristande underlag ochbegränsade resurser. Eftersom det generellt är svårt att utvärdera det specifika bidraget av de berörda ersättningarna till en giftfri miljö, kan utvärderingen därför inte på ett tillfredställande sätt svara på hur stor deras bidrag till detta miljökvalitetsmål har varit.När det gäller klimatåtgärder har programmet ett tydligt fokus på produktion ochanvändning av energi och relaterade emissioner av växthusgaser. Samtidigt konstateras det att emissionerna av växthusgaser från jordbrukssektorn primärt härrör från biogena processer i form av metan från idisslarnas matsmältning och lustgas från det kväve som tillförs åkermarken. För en fortsatt reduktion av jordbrukssektorns emissioner av växthusgaser bör satsningarna på en minskad användning av fossila bränslen fortsätta, men det är samtidigt nödvändigt att lägga ett större fokus på de biogena emissionerna. För att tydliggöra vikten av klimatåtgärder och satsningar på förnybar energi bör dessa insatser också lyftas fram som egna åtgärder istället för att finnas insprängda bland åtgärder som har annat huvudfokus.För ett fåtal åtgärder och ersättningar har det gått att härleda möjliga sysselsättningseffekter via de markanvändningseffekter som estimerats med modeller. Även om dessa resultat bör tolkas med stor försiktighet, bedöms sysselsättningseffekten av miljöåtgärderna generellt vara marginellt positiv. Ersättningen Skötsel av betesmarker och slåtterängar har i beräkningar som bygger på kontrafaktiska markanvändningsscenarier lett till en märkbar förändring av markanvändningen (ökad areal betesmarker med stöd) vilket, eftersom animalieproduktion generellt anses vara mer tidskrävande än spannmålsproduktion, bedöms leda till högre sysselsättning. Extensiv vallodling och kompensationsbidrag har däremot en mycket begränsad påverkanpå markanvändningen, varför sysselsättningseffekten bedöms som marginell.Generella förbättringsförslag inför utformningen av kommande programÄven om utvärderarnas samlade bedömning är att landsbygdsprogrammets upplägg, d.v.s. dess syften och motiv, ingående medel och val av åtgärder, är relevant och generellt bidrar till att förbättra situationen för miljö och klimat, så finns det en hel del som kan och bör förbättras för att möjliggöra kostnadseffektiva program i framtiden. De enstaka insatsernas syften och mål bör preciseras och kopplas till tydliga indikatorer som på ett relevant sätt kan mäta måluppfyllandet. Detta är avgörande för att man ska kunna utforma ett kostnadseffektivt landsbygdsprogram och utvärdera det på ett adekvat sätt. Dessutom behöver beskrivningarna för syften och motiv för många av ersättningarna ses över och anpassas till det aktuella kunskapsläget. Exempelvis skulle syftet ”bevara biologisk mångfald” leda till helt olika åtgärder beroende på om man vill bevara sällsynta arter eller ekosystemtjänstgynnare.Det empiriska underlaget för utvärdering behöver stärkas inför utvärderingen avframtida landsbygdsprogram. Detta kan exempelvis göras genom systematiskaöversikter och empirisk primärforskning som undersöker konsekvenser av olikaåtgärder. För att optimera detta bör utvärderingen byggas in som en organisk del av landsbygdsprogrammet. Utredarna föreslår att en procent av programmets budget används till att utforma och implementera relevanta metoder för kontinuerlig insamling av lämplig data under hela programperioden.För att i högre grad kunna utvärdera landsbygdsprogrammets kostnadseffektivitetkrävs en fortsatt utveckling av metoder för att studera konsekvenserna för målet av att åtgärden/insatsen/delinsatsen finns eller inte finns (eller var annorlunda utformad) (kontrafaktiska scenarier) och modeller som föruts
|
|
| 17. |
- Sturkell, Erik, 1962, et al.
(författare)
-
Concentric impact structures in the Palaeozoic of Sweden - the Lockne and Siljan craters
- 2010
-
Ingår i: GFF. - : Informa UK Limited. - 1103-5897 .- 2000-0863. ; 132:1, s. 65-70
-
Tidskriftsartikel (refereegranskat)abstract
- The Ordovician age Lockne and Devonian Siljan craters are two of the largest impact structures in northern Europe. Both formed in targets with a thick, low-strength upper layer. This target configuration is known to generate concentric crater structures with an outer, shallow crater in the low-strength layer, surrounding a central, deeper crater in the more resistant substrate. The concentric craters of Lockne and Siljan are excellent models for studies of similar concentric craters on Earth and elsewhere in the Solar system. Several structural issues remain, and drilling through the craters within the Swedish Deep Drilling Program intends to address the following: the extent of the craters with respect to the time of impact; the effects of cratering on the basement; and the role of basement structure for the crater formation. A problem for the Lockne crater is the relation to the Caledonian orogeny and the lateral extension of the ejecta blanket - the rim is interrupted by a radial depression that has been interpreted both as primary and secondary, tectonically induced. A second feature to study is the deeper and older (1.82-1.80 Ga) NNW-SSE shear zones that cut the basement. In the Siljan area the development of mega block associations comprising the infilling of the graben is disputed. The blocks may either be formed by sagging of peripheral parts of the fault blocks or alternatively by major radial movement involving kilometre long transport.
|
|
| 18. |
|
|
| 19. |
- Tufvesson, Oscar, et al.
(författare)
-
Spatial Statistical Modeling of Insurance Risk An epidemiologist approach to car insurance
- 2017
-
Konferensbidrag (refereegranskat)abstract
- Spatial models, such as the Besag, York and Mollie (BYM)model, have long been used in epidemiology and disease mapping. A commonproblem in these subjects is the modelling of number of disease eventsper region; here the BYM models provides a holistic framework for bothcovariates and dependencies between regions.We use these tools to assess the relative insurance risk associated withthe policyholders geographical location. The models are placed in a Bayesianframework, and inference is made using Integrated Nested Laplace Approximation(INLA).The model is applied to car insurance data from If P&C Insurance togetherwith spatial referenced covariate data of high resolution, provided byInsightone. Including spatially dependence in the modelling of number ofclaims signicantly improves on the result obtained using ordinary generalisedlinear models. However, the support for adding a spatial componentto the model for claims cost is weaker.
|
|
| 20. |
- Tufvesson, Oskar, et al.
(författare)
-
Spatial statistical modelling of insurance risk : a spatial epidemiological approach to car insurance
- 2019
-
Ingår i: Scandinavian Actuarial Journal. - : Informa UK Limited. - 0346-1238 .- 1651-2030. ; 2019:6, s. 508-522
-
Tidskriftsartikel (refereegranskat)abstract
- Spatial models, such as the Besag, York and Mollie (BYM) model, have long been used in epidemiology and disease mapping. A common research question in these subjects is modelling the number of disease events per region; here the BYM models provides a holistic framework for both covariates and dependencies between regions. We use these tools to assess the relative insurance risk associated with the policyholders geographical location. A Bayesian modelling approach is presented and an elastic net is used to reduce the large number of possible geographic covariates. The final inference is performed using Integrated Nested Laplace Approximation. The model is applied to car insurance data from If P&C Insurance together with spatially referenced covariate data of high resolution, provided by Insightone. The entire analysis is performed using freely available R-packages. Including spatial dependence when modelling the number of claims significantly improves on the result obtained using ordinary generalised linear models. However, the support for adding a spatial component to the model for claims cost is weaker.
|
|
| 21. |
- Wernersson, Lars-Erik, et al.
(författare)
-
Circuits and devices with integrated VFETs and RTDs
- 2002
-
Ingår i: 2002 IEEE International Symposium on Circuits and Systems. Proceedings (Cat. No.02CH37353). - 0780374487 ; , s. 205-208
-
Konferensbidrag (refereegranskat)abstract
- We have realised a new technology for the integration of VFETs and RTDs. For these tunnelling transistors (so called resonant tunnelling permeable base transistors) we have developed large signal models which have been implemented in a Cadence simulation environment. The DC I-V characteristics are reproduced to a very high degree in these models. The models are further used for simulations of the behaviour of simple small-scale circuits including resonant tunnelling transistors. Examples of circuits studied are a monostable-bistable logic element and a ternary quantiser, where the later is based on a new 3D architecture of RTDs and VFETs
|
|
| 22. |
- Wernersson, Lars-Erik, et al.
(författare)
-
Highly functional tunnelling devices integrated in 3D
- 2003
-
Ingår i: International Journal of Circuit Theory and Applications. - : Wiley. - 1097-007X .- 0098-9886. ; 31:1, s. 105-117
-
Tidskriftsartikel (refereegranskat)abstract
- We present a new technology for integrating tunnelling devices in three dimensions. These devices are fabricated by the combination of the growth of semiconductor heterostructures with the controlled introduction of metallic elements into an epitaxial layer by an overgrowth technique. First, we use a new type of tunnelling transistor, namely a resonant-tunnelling permeable base transistor. A simple model based on a piece-wise linear approximation is used in Cadence to describe the current-voltage characteristics of the transistor. This model is further introduced into a small signal equivalent circuit in order to optimize the performance of the device. In addition to the tunnelling structure below the grating, these transistors may be integrated in 3D by the introduction of another tunnelling structure directly over the metal grating. In the integrated device structure, the gate acts simultaneously on both tunnelling structures and the obtained characteristics are the result of the interplay between the two tunnelling structures and the gate. An equivalent circuit model is developed and we show how this interaction influences the current-voltage characteristics. The gate may be used to adjust the peak voltage of certain peaks in a controlled fashion, which creates a highly functional tunnelling device. These results show the need for a strong interaction between the development of circuit models and processing technology to develop new nano-electronic devices and circuits.
|
|
| 23. |
- Wernersson, Lars-Erik, et al.
(författare)
-
Nanoelectronic pulse generators based on gated resonant tunnelling diodes
- 2004
-
Ingår i: International Journal of Circuit Theory and Applications. - : Wiley. - 1097-007X .- 0098-9886. ; 32:5, s. 431-437
-
Tidskriftsartikel (refereegranskat)abstract
- We study the operation of a gated resonant tunnel diode placed in an oscillator tank circuit for application as a pulse generator. The gated diode is realized by a metal gate placed 30nm away from a resonant tunnelling double barrier heterostructure, where the gate is used to control the current of the tunnelling diode. A large signal model is developed for the gated resonant tunnelling diode and we use this model to study the operation of the pulsed oscillator. It is demonstrated that the gate can be used to switch the oscillations on and off and to tune the oscillation frequency via changes in the internal capacitances in the gated diode. A modulation in the oscillation frequency of 7.6 GHz around 220 GHz is obtained for a change in the gate bias from 0.2 to -0.6 V. Short pulses applied to the gate results in only four periods of oscillation with a broad power spectrum.
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
- Almbjär, Martin, 1982-
(författare)
-
The voice of the people? : Supplications submitted to the Swedish Diet in the Age of Liberty, 1719–1772
- 2016
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation is devoted to the study of who used the formal channels of interaction in the early modern era and why. It examines the full range of the political conversation in early modern Sweden, as seen in the supplications to the Diet in the Age of Liberty (1719–1772), and more specifically the supplications submitted to the parliamentary committee tasked with handling them, the Screening Deputation. The literature yields few systematic studies of this official channel, and supplications have long been terra incognita in the early modern political landscape. Their exact importance is uncertain, to say the least.Using a database built on three samples from the beginning, middle, and end of the Age of Liberty, the Diet's supplication channel is shown to have been used by two groups: supplicants from state-affiliated households primarily tried to use it to pursue their claims on the state, to settle various issues related to employment, or to receive some sort of support through hard times; and, increasingly, commoners, especially delegates in the Estate of the Burghers, used the channel for their gravamina concerning commerce, taxation, and the like, and state support for public amenities, a group for whom the Screening Deputation offered an alternative route to getting their grievances heard by the Diet. Both groups increasingly used the Diet's supplication channel was appeal the verdicts of the King in Council (Kungl. Maj:t). Although most were not appeals against the Judicial Audit, the results reveal an active use of appeals, and thus a de facto erosion of Kungl. Maj:t's supremacy. The results also show that as many as three-fifths of all supplicants had their supplications accepted by the Screening Deputation for further examination by the Diet. Although the acceptance rate was definitely lower in the 1730s and 1740s, the committee seems to have been fairly benevolent in its interpretation of the rules on petitioning.The results, lastly, show that although the Diet's supplication channel allowed excluded groups direct access to the Diet - including women of all classes, commoners of rank, and unrepresented groups - it mainly catered to men with the social status or wealth that put them in the middle and upper strata of society. Although this supplication channel stood open to anyone, its egalitarian potential was seemingly never realized. The use of March and Olsen's institutional theory about the logic of appropriateness, has revealed that certain institutional templates and norms that would have enabled these groups more access to the channel succumbed and made room for other institutional foundations.Supplications were part of the medieval and early modern centralization of legal and political power, the formation of the state, the protection of the privileges of Swedish subjects, and, during the Age of Liberty, the power struggle between the Diet and the kings. Each supplication viewed by itself might seem trivial, but nonetheless played a part in each and every one of these major processes. An ordinary Swede could have an impact on early modern politics when acting in concert with other supplicants, like rain eating away at rock.
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
- Andrén, Samuel, et al.
(författare)
-
Assessing Alignment Between Business and IT Strategy : A Case Study
- 2020
-
Ingår i: Proceedings of the Forum at Practice of Enterprise Modeling 2020 co-located with the 13th IFIP WG 8.1 Working Conference on the Practice of Enterprise Modeling (PoEM 2020). - : CEUR-WS. ; , s. 1-12
-
Konferensbidrag (refereegranskat)abstract
- Strategic alignment between business and IT is a topic of high importance to modern businesses, but it remainsproblematic to implement structured methods to improve and assess alignment in many organisations. Thisstudy investigates how organisations can better leverage published strategic alignment theory and methods,finding that previous research has not sufficiently considered the different dimensions of strategy and thatsuch considerations would help enterprises improve strategic alignment. The study proposes a framework forunderstanding strategic alignment in hierarchical business-led organisations, exemplified in a case study ofTrafikförvaltningen, the Stockholm public transport authority.
|
|
| 33. |
- Asp, Vendela, et al.
(författare)
-
Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells
- 2010
-
Ingår i: Toxicology and Applied Pharmacology. - : Elsevier BV. - 0041-008X .- 1096-0333. ; 242:3, s. 281-289
-
Tidskriftsartikel (refereegranskat)abstract
- The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO(2)-DDE) has been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) treatment. ACC is a rare malignant disorder with poor prognosis, and the current pharmacological therapy o,p'-DDD (mitotane) has limited efficacy and causes severe adverse effects. 3-MeSO(2)-DDE is bioactivated by cytochrome P450 (CYP) 11B1 in mice and causes formation of irreversibly bound protein adducts, reduced glucocorticoid secretion, and cell death in the adrenal cortex of several animal species. The present study was carried out to assess similarities and differences between mice and humans concerning the adrenocorticolytic effects of 3-MeSO(2)-DDE. The results support previous indications that humans are sensitive to the adrenocorticolytic actions of 3-MeSO(2)-DDE by demonstrating protein adduct formation and cytotoxicity in the human adrenocortical cell line H295R. However, neither the irreversible binding nor the cytotoxicity of 3-MeSO(2)-DDE in H295R cells was inhibited by the CYP11B1 inhibitor etomidate. We also report biphasic responses to 3-MeSO(2)-DDE in cortisol and aldosterone secretion as well as in mRNA levels of the steroidogenic genes StAR, CYP11B1 and CYP11B2. Hormone levels and mRNA levels were increased at lower concentrations of 3-MeSO(2)-DDE, while higher concentrations decreased hormone levels. These biphasic responses were not observed with o,p'-DDD or with the precursor DDT metabolite p,p'-DDE. Based on these results, 3-MeSO(2)-DDE remains a viable lead compound for drug design, although the adrenocorticolytic effects of 3-MeSO(2)-DDE in human cells seem more complex than in murine cells.
|
|
| 34. |
- Aulin, Christian, et al.
(författare)
-
Self-Organized Films from Cellulose I Nanofibrils Using the Layer-by-Layer Technique
- 2010
-
Ingår i: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 11:4, s. 872-882
-
Tidskriftsartikel (refereegranskat)abstract
- The possibility of forming self-organized films using only charge-stabilized dispersions of cellulose I nanofibrils with opposite charges is presented, that is, the multilayers were composed solely of anionically and cationically modified microfibrillated cellulose (MFC) with a low degree of substitution. The build-up behavior and the properties of the layer-by-layer (LbL)-constructed films were studied using a quartz crystal microbalance with dissipation (QCM-D) and stagnation point adsorption reflectometry (SPAR). The adsorption behavior of cationic/anionic MFC was compared with that of polyethyleneimine (PEI)/anionic MFC. The water contents of five bilayers of cationic/anionic MFC and PEI/anionic MFC were approximately 70 and 50%, respectively. The MFC surface coverage was studied by atomic force microscopy (AFM) measurements, which clearly showed a more dense fibrillar structure in the five bilayer PEI/anionic MFC than in the five bilayer cationic/anionic MFC. The forces between the cellulose-based multilayers were examined using the AFM colloidal probe technique. The forces on approach were characterized by a combination of electrostatic and steric repulsion. The wet adhesive forces were very long-range and were characterized by multiple adhesive events. Surfaces covered by PEU/anionic MFC multilayers required more energy to be separated than surfaces covered by cationic/anionic MFC multilayers.
|
|
| 35. |
- Bah Rösman, Jessica, 1975, et al.
(författare)
-
Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters
- 2008
-
Ingår i: Psychiatry Research: Neuroimaging. - : Elsevier BV. - 0925-4927 .- 0165-1781. ; 162:3, s. 221-229
-
Tidskriftsartikel (refereegranskat)abstract
- The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using I-123-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters.
|
|
| 36. |
|
|
| 37. |
- Bergqvist, Erik, et al.
(författare)
-
Health care utilisation two years prior to suicide in Sweden: a retrospective explorative study based on medical records
- 2022
-
Ingår i: BMC Health Services Research. - : Springer Science and Business Media LLC. - 1472-6963. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Objective Previous literature has suggested that identifying putative differences in health care seeking patterns before death by suicide depending on age and gender may facilitate more targeted suicide preventive approaches. The aim of this study is to map health care utilisation among individuals in the two years prior to suicide in Sweden in 2015 and to examine possible age and gender differences. Methods Design: A retrospective explorative study with a medical record review covering the two years preceding suicide. Setting: All health care units located in 20 of Sweden's 21 regions. Participants: All individuals residing in participating regions who died by suicide during 2015 (n = 949). Results Almost 74% were in contact with a health care provider during the 3 months prior to suicide, and 60% within 4 weeks. Overall health care utilisation during the last month of life did not differ between age groups. However, a higher proportion of younger individuals (< 65 years) were in contact with psychiatric services, and a higher proportion of older individuals (>= 65 years) were in contact with primary and specialised somatic health care. The proportion of women with any type of health care contact during the observation period was larger than the corresponding proportion of men, although no gender difference was found among primary and specialised somatic health care users within four weeks and three months respectively prior to suicide. Conclusion Care utilisation before suicide varied by gender and age. Female suicide decedents seem to utilise health care to a larger extent than male decedents in the two years preceding death, except for the non-psychiatric services in closer proximity to death. Older adults seem to predominantly use non-psychiatric services, while younger individuals seek psychiatric services to a larger extent.
|
|
| 38. |
|
|
| 39. |
- Björklund, Lars-Erik, 1953-
(författare)
-
Från novis till expert : förtrogenhetskunskap i kognitiv och didaktisk belysning
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med den här avhandlingen är att bidra till förståelsen av beprövad erfarenhetsbaserad kunskap, det vi förknippar med fårdigheter, förmågor och förtrogenhet. Avhandlingen är enintegrerande forskningsöversikt, fntegrative research review. Genom att sammanställa, jämföra och integrera resultat från psykologins, beteendevetenskapens, neuromedicinens och neurofysiologins forskningsfålt synliggör författaren en neurodidaktisk modell för hur experters egenskaper och förmågor byggs upp under praktisk erfarenhet i en specifik kontext.När en engagerad individ utsätts för en upprepad variation av upplevelser skapas kunskap som består av utfallsmärkta sensoriska mönster i framför allt de basala ganglierna men även i amygdala och cerebellum. Dessa sammantaget utgör ett implicit, omedvetet inlärningssystem parallellt med det medvetna explicita. Det implicita systemet jämför det vi betraktar med tidigare lagrade mönster vilket gör att vi snabbt kan upptäcka vad som är relevant i komplexa, stressade situationer. Med dess hjälp blir vi mer kompetenta i vår roll som lärare, hantverkare, läkare etc. Den här kunskapen blir omedveten, dold och tyst, det som Polanyi kallar Tacit knowledge och som bröderna Dreyfus refererar till som holistic pattern recognition. När vårt medvetande uppmärksammar ett igenkännande i det implicita systemet upplever vi en känsla, intuition eller gut feeling. Det implicita bedömningssystemet hämmas inte av arbetsminnets begränsningar i hastighet och antal detaljer och blir med tiden en resurs som visar sig som förtrogenhet inom en praktik. Mycket talar för att de mönster och erfarenheter som lagras i det implicita systemet används vid problemlösning. Detta leder till implikationer för hur undervisning och lärandemiljöer i exempelvis teknikämnet ska planeras för att befrämja en kreativ utveckling hos den lärande.Det implicita systemet ger oss en omedveten kapacitet att tolka andra människors kroppsspråk och aktiveras av kända kontexter och artefakter. Detta påverkar de svar vi som forskare får från våra informanter i en intervjusituation. För att nå expertens tysta kunskap om t.ex. bedömningskriterier kan en speciell intervjumetod; Repertory Grid Technique, användas.
|
|
| 40. |
- Björkman, Mattias, et al.
(författare)
-
A New Concept for Motion Control of Industrial Robots
- 2008
-
Ingår i: Proceedings of the 17th IFAC World Congress. - Linköping : Linköping University Electronic Press. - 9783902661005
-
Konferensbidrag (refereegranskat)abstract
- This paper gives a short summary of an industrial development work on model-based motion control. This development has resultet in high robot motion performance simultaneously with an efficient use of the installed drive system of the robot.
|
|
| 41. |
- Björkqvist, Maria, et al.
(författare)
-
Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca(2+) channels.
- 2005
-
Ingår i: Regulatory Peptides. - : Elsevier BV. - 1873-1686 .- 0167-0115. ; 130:1-2, s. 81-90
-
Tidskriftsartikel (refereegranskat)abstract
- The oxyntic mucosa is rich in ECL cells. They secrete histamine and chromogranin A-derived peptides, such as pancreastatin, in response to gastrin and pituitary adenylate cyclase-activating peptide (PACAP). Secretion is initiated by Ca2+ entry. While gastrin stimulates secretion by opening L-type and N-type Ca2+ channels, PACAP stimulates secretion by activating L-type and receptor-operated Ca2+ channels. Somatostatin, galanin and prostaglandin E2 (PGE2) inhibit gastrin- and PACAP-stimulated secretion from the ECL cells. In the present study, somatostatin and the PGE2 congener misoprostol inhibited gastrin- and PACAP-stimulated secretion 100%, while galanin inhibited at most 60–65%. Bay K 8644, a specific activator of L-type Ca2+ channels, stimulated ECL-cell secretion, an effect that was inhibited equally effectively by somatostatin, misoprostol and galanin (75–80% inhibition). Pretreatment with pertussis toxin, that inactivates inhibitory G-proteins, prevented all three agents from inhibiting stimulated secretion (regardless of the stimulus). Pretreatment with nifedipine (10 μM), an L-type Ca2+ channel blocker, reduced PACAP-evoked pancreastatin secretion by 50–60%, gastrin-evoked secretion by not, vert, similar 80% and abolished the response to Bay K 8644. The nifedipine-resistant response to PACAP was abolished by somatostatin and misoprostol but not by galanin. Gastrin and PACAP raised the intracellular Ca2+ concentration in a biphasic manner, believed to reflect mobilization of internal Ca2+ followed by Ca2+ entry. Somatostatin and misoprostol blocked Ca2+ entry (and histamine and pancreastatin secretion) but not mobilization of internal Ca2+. The present observations on isolated ECL cells suggest that Ca2+ entry rather than mobilization of internal Ca2+ triggers exocytosis, that gastrin and PACAP activate different (but over-lapping) Ca2+ channels, that somatostatin, misoprostol and galanin interact with inhibitory G-proteins to block Ca2+ entry via L-type Ca2+ channels, and that somatostatin and misoprostol (but not galanin) in addition block N-type and/or receptor-operated Ca2+ channels.
|
|
| 42. |
- Bobbio, Emanuele, et al.
(författare)
-
Diagnosis, management, and outcome of cardiac sarcoidosis and giant cell myocarditis: a Swedish single center experience.
- 2022
-
Ingår i: BMC cardiovascular disorders. - : Springer Science and Business Media LLC. - 1471-2261. ; 22
-
Tidskriftsartikel (refereegranskat)abstract
- Cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) are rare diseases that share some similarities, but also display different clinical and histopathological features. We aimed to compare the demographics, clinical presentation, and outcome of patients diagnosed with CS or GCM.We compared the clinical data and outcome of all adult patients with CS (n=71) or GCM (n=21) diagnosed at our center between 1991 and 2020.The median (interquartile range) follow-up time for patients with CS and GCM was 33.5 [6.5-60.9] and 2.98 [0.6-40.9] months, respectively. In the entire cohort, heart failure (HF) was the most common presenting manifestation (31%), followed by ventricular arrhythmias (25%). At presentation, a left ventricular ejection fraction of<50% was found in 54% of the CS compared to 86% of the GCM patients (P=0.014), while corresponding proportions for right ventricular dysfunction were 24% and 52% (P=0.026), respectively. Advanced HF (NYHA≥IIIB) was less common in CS (31%) than in GCM (76%). CS patients displayed significantly lower circulating levels of natriuretic peptides (P<0.001) and troponins (P=0.014). Eighteen percent of patients with CS included in the survival analysis reached the composite endpoint of death or heart transplantation (HTx) compared to 68% of patients with GCM (P<0.001).GCM has a more fulminant clinical course than CS with severe biventricular failure, higher levels of circulating biomarkers and an increased need for HTx. The histopathologic diagnosis remained key determinant even after adjustment for markers of cardiac dysfunction.
|
|
| 43. |
- Bommarco, Riccardo, et al.
(författare)
-
Bees increase seed set of wild plants while the proportion of arable land has a variable effect on pollination in European agricultural landscapes
- 2021
-
Ingår i: Plant Ecology and Evolution. - : Agentschap Plantentuin Meise. - 2032-3913 .- 2032-3921. ; 154, s. 341-350
-
Tidskriftsartikel (refereegranskat)abstract
- Background and aims - Agricultural intensification and loss of farmland heterogeneity have contributed to population declines of wild bees and other pollinators, which may have caused subsequent declines in insect-pollinated wild plants. Material and methods - Using data from 37 studies on 22 pollinator-dependent wild plant species across Europe, we investigated whether flower visitation and seed set of insect-pollinated plants decline with an increasing proportion of arable land within 1 km. Key results - Seed set increased with increasing flower visitation by bees, most of which were wild bees, but not with increasing flower visitation by other insects. Increasing proportion of arable land had a strongly variable effect on seed set and flower visitation by bees across studies. Conclusion - Factors such as landscape configuration, local habitat quality, and temporally changing resource availability (e.g. due to mass-flowering crops or honey bee hives) could have modified the effect of arable land on pollination. While our results highlight that the persistence of wild bees is crucial to maintain plant diversity, we also show that pollen limitation due to declining bee populations in homogenized agricultural landscapes is not a universal driver causing parallel losses of bees and insect-pollinated plants.
|
|
| 44. |
- Brain, Cecilia, 1969, et al.
(författare)
-
Drug attitude and other predictors of medication adherence in schizophrenia : 12 months of electronic monitoring (MEMS (R)) in the Swedish COAST-study
- 2013
-
Ingår i: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 23:12, s. 1754-1762
-
Tidskriftsartikel (refereegranskat)abstract
- The aim was to investigate clinical predictors of adherence to antipsychotics. Medication use was electronically monitored with a Medication Event Monitoring System (MEMS (R)) for 12 months in 112 outpatients with schizophrenia and schizophrenia-like psychosis according to DSM-IV. Symptom burden, insight, psychosocial function (PSP) and side effects were rated at baseline. A comprehensive neuropsychological test battery was administered and a global composite score was calculated. The Drug Attitude Inventory (DAI-10) was filled in. A slightly modified DAI-10 version for informants was distributed as a postal questionnaire. Nonadherence (MEMS (R) adherence <= 0.80) was observed in 27%. In univariate regression models low scores on DAI-10 and DAI-10 informant, higher positive symptom burden, poor function, psychiatric side effects and lack of insight predicted non-adherence. No association was observed with global cognitive function. In multivariate regression models, low patient-rated DAI-10 and PSP scores emerged as predictors of non-adherence. A ROC analysis showed that DAI-10 had a moderate ability to correctly identify non-adherent patients (AUC=0.73, p<0.001). At the most "optimal" cut-off of 4, one-third of the adherent would falsely be. identified as non-adherent. A somewhat larger AUC (0.78, p<0.001) was observed when the ROC procedure was applied to the final regression model including DAI-10 and PSP. For the subgroup with informant data, the AUC for the DAI-10 informant version was 0.68 (p=0.021). Non-adherence cannot be properly predicted in the clinical setting on the basis of these instruments alone. The DAI-10 informant questionnaire needs further testing.
|
|
| 45. |
- Brain, Cecilia, 1969, et al.
(författare)
-
Stigma, discrimination and medication adherence in schizophrenia: Results from the Swedish COAST study
- 2014
-
Ingår i: Psychiatry Research. - : Elsevier BV. - 0165-1781 .- 1872-7123. ; 2014:220(3), s. 811-817
-
Tidskriftsartikel (refereegranskat)abstract
- The aims of thisn aturalistic non-interventional study were to quantify the level of stigma and discrimination in persons with schizophrenia and to test for potential associations between different types of stigma and adherence to antipsychotics. Antipsychotic medication use was electronically monitored with a Medication Event Monitoring System (MEMS) for 12 months in 111 outpatients with schizophrenia and schizophrenia-like psychosis (DSM-IV). Stigma was assessed at endpoint using the Discrimination and Stigma Scale (DISC). Single DISC items that were most frequently reported included social relationships in making /keeping friends (71%) and in the neighborhood (69%). About half of the patients experienced discrimination by their families, in intimate relationships, regarding employment and by mental health staff. Most patients (88%) wanted to conceal their mental health problems from others; 70% stated that anticipated discrimination resulted in avoidance of close personal relationships. Non-adherence (MEMS adherencer 0.80) was observed in 30 (27.3%). When DISC subscale scores (SD) were entered in separate regression models, neither experienced nor anticipated stigma was associated with adherence. Our data do not support an association between stigma and non-adherence. Further studies in other settings are needed as experiences of stigma and levels of adherence and their potential associations might vary by health care system or cultural and sociodemographic contexts.
|
|
| 46. |
- Burnett, J., et al.
(författare)
-
PC2: Identifying noise processes in superconducting resonators
- 2013
-
Ingår i: 2013 IEEE 14th InternationalSuperconductive Electronics Conference, ISEC 2013. - 9781467363716 ; , s. Art. no. 6604284-
-
Konferensbidrag (refereegranskat)abstract
- Extensive studies of dielectric loss due to two level fluctuators (TLFs) in superconducting resonators have provided routes for low loss resonators. The research is motivated not only by the use of resonators as detectors and in quantum information processing, but more generally due to TLFs being a source of noise and decoherence in all quantum devices. In this work a frequency locked loop was used to measure frequency fluctuations at timescales in excess of 104 seconds, thereby accurately probing the TLF induced low- frequency noise of the resonator. Our measurement method lead to very high statistical confidence even for very long timescales, and here we can therefore present results explicitly identifying power dependent flicker frequency noise (S = 1/fa where a=1) persisting down to the mHz level.
|
|
| 47. |
- Christopeit, Tony, et al.
(författare)
-
A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane
- 2011
-
Ingår i: Analytical Biochemistry. - : Elsevier BV. - 0003-2697 .- 1096-0309. ; 414:1, s. 14-22
-
Tidskriftsartikel (refereegranskat)abstract
- A surface plasmon resonance (SPR) biosensor-based assay for membrane-embedded full-length BACE1 (β-site amyloid precursor protein cleaving enzyme 1), a drug target for Alzheimer's disease, has been developed. It allows the analysis of interactions with the protein in its natural lipid membrane environment. The enzyme was captured via an antibody recognizing a C-terminal His6 tag, after which a lipid membrane was reconstituted on the chip using a brain lipid extract. The interaction between the enzyme and several inhibitors confirmed that the surface was functional. It had slightly different interaction characteristics as compared with a reference surface with immobilized ectodomain BACE1 but had the same inhibitor characteristic pH effect. The possibility of studying interactions with BACE1 under more physiological conditions than assays using truncated enzyme or conditions dictated by high enzyme activity is expected to increase our understanding of the role of BACE1 in Alzheimer's disease and contribute to the discovery of clinically efficient BACE1 inhibitors. The strategy exploited in the current study can be adapted to other membrane-bound drug targets by selecting suitable capture antibodies and lipid mixtures for membrane reconstitution.
|
|
| 48. |
- Cortese, Federico, et al.
(författare)
-
GENERALIZED INFORMATION CRITERIA FOR SPARSE STATISTICAL JUMP MODELS
- 2023
-
Ingår i: Symposium i anvendt statistik 2023. - 9788798937036 ; , s. 68-78
-
Bokkapitel (refereegranskat)abstract
- We extend the generalized information criteria for high-dimensional penalizedmodels to sparse statistical jump models, a new class of statistically robust and computationally efficient alternatives to hidden Markov models. In a simulation study, we demonstrate that the new generalized information criteria selects the correct hyperparameters with high probability. Finally, providing an empirical application, we infer the key features that drive the return dynamics of the largest cryptocurrencies. We find that a four-state model best describes the dynamics of cryptocurrency returns. The states have natural market-based interpretations as they correspond to bull, bull-neutral, bear-neutral, and bear market regimes, respectively.
|
|
| 49. |
- Cortese, Federico P., et al.
(författare)
-
What drives cryptocurrency returns? A sparse statistical jump model approach
- 2023
-
Ingår i: Digital Finance. - 2524-6984.
-
Tidskriftsartikel (refereegranskat)abstract
- We apply the statistical sparse jump model, a recently developed, interpretable and robust regime-switching model, to infer key features that drive the return dynamics of the largest cryptocurrencies. The algorithm jointly performs feature selection, parameter estimation, and state classification. Our large set of candidate features are based on cryptocurrency, sentiment and financial market-based time series that have been identified in the emerging literature to affect cryptocurrency returns, while others are new. In our empirical work, we demonstrate that a three-state model best describes the dynamics of cryptocurrency returns. The states have natural market-based interpretations as they correspond to bull, neutral, and bear market regimes, respectively. Using the data-driven feature selection methodology, we are able to determine which features are important and which ones are not. In particular, out of the set of candidate features, we show that first moments of returns, features representing trends and reversal signals, market activity and public attention are key drivers of crypto market dynamics.
|
|
| 50. |
- Cortese, Federico, et al.
(författare)
-
What drives cryptocurrency returns? A sparse statistical jump model approach
- 2023
-
Konferensbidrag (refereegranskat)abstract
- The statistical sparse jump model, a recently developed, robust and interpretable regime-switching model, is used to analyze the factors driving the return dynamics of the largest cryptocurrencies. This method simultaneously incorporates feature selection, parameter estimation, and state classification. A wide range of candidate features is considered, including cryptocurrency, sentiment, and financial market-based time series that are known to influence cryptocurrency returns. The empirical analysis demonstrates that a three-state model provides a good representation of the cryptocurrency return dynamics. The latent states are interpreted as a bull, neutral, and bear market regimes, respectively. Through the data-driven feature selection approach, the significant factors are identified, and insignificant ones are excluded. The results indicate that within the candidate features, the first moments of returns, features indicating trends and reversal signals, market activity, and public attention are key drivers of crypto market dynamics.
|
|
