| 1. |
- Li, Yifei, et al.
(författare)
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Can Nup88 expression be associated with atypical endometrial hyperplasia and endometrial cancer? A preliminary study
- 2016
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Ingår i: Pathology, Research and Practice. - : ELSEVIER GMBH, URBAN & FISCHER VERLAG. - 0344-0338 .- 1618-0631. ; 212:4, s. 274-278
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Tidskriftsartikel (refereegranskat)abstract
- Background: Nup88 is overexpressed in a number of types of carcinomas and is associated with myometrial invasion, but its exact expression pattern in endometrial cancer and premalignant lesions is unknown. Aims: To evaluate the role of Nup88 in endometrial cancers and atypical endometrial hyperplasia and its clinicopathological significance. Methods: Nup88 expression was examined by immunohistochemistry in samples from 104 endometrial cancers, 21 atypical endometrial hyperplasia lesions, and 40 normal endometria. All samples were from patients who underwent surgery at the First Hospital of Hebei Medical University (Shijiazhuang, China) between April 2006 and December 2009. Nup88 expression was compared between the groups and associations were assessed between Nup88 and clinicopathological characteristics of the subjects. Results: Nup88 expression in cancer (76% of samples) and atypical hyperplasia (91%) was significantly higher compared to normal endometrium (33%, both P < 0.001), but there was no significant difference between endometrial cancer and atypical hyperplasia (P = 0.237). The expression of Nup88 increased significantly with increasing exposure time to estrogen (P = 0.033). Conclusions: Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions. Nup88 might be a useful biomarker for pre-malignant lesions and early-stage endometrial cancer. (C) 2016 Elsevier GmbH. All rights reserved.
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| 2. |
- Li, Rui, et al.
(författare)
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Twisted or Planar? Side-Chain Tailoring of Fluorene-based Hole-Transport Materials for Efficient and Stable Perovskite Solar Cells
- 2023
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Ingår i: Solar RRL. - 2367-198X. ; 7:18
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Tidskriftsartikel (refereegranskat)abstract
- The functionalization of small-molecule hole-transport materials (HTMs) heavily relies on the rational design of molecular geometry, which can optimize both intrinsic HTM properties and interfacial properties for realizing high-performance and stable lead halide perovskite solar cells (LHPSCs). Herein, two fluorene-based donor–π linker–donor HTMs are seen, FL01 and FL02, whose side chains are tailored with planar phenyl-carbazole groups and twisted triphenylamine groups, respectively. Benefiting from the high conformational flexibility of twisted side chains, the strong and oriented interaction via PbO bonding is well coordinated at the perovskite and FL02 interface, which favors the interfacial charge transfer as well as the protection of perovskite layer by effectively blocking or mitigating the diffusion of hygroscopic dopants toward the perovskite surface. Consequently, the performance of FL02 HTM-based n–i–p LHPSCs is significantly enhanced by achieving a power conversion efficiency of 17.8%, which is twice higher than that (8.6%) of FL01 HTM-based ones and comparable with the case (18.8%) of conventional spiro-OMeTAD HTM-based devices. More importantly, the FL02-based devices exhibit impressively high operation and storage stabilities with T80 and TS80 lifetimes of >98 h and ≈270 days, respectively, which are among the longest lifespans for the type of hygroscopically doped LHPSCs.
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| 3. |
- Li, Yifei, et al.
(författare)
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Expression and clinical significance of FXYD3 in endometrial cancer
- 2014
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Ingår i: Oncology Letters. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 8:2, s. 517-522
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Tidskriftsartikel (refereegranskat)abstract
- FXYD3 expression is upregulated in numerous cancer cell types. The present study compared the FXDY3 expression in normal endometrium, premalignant lesion and endometrial cancer tissue samples, and investigated the correlation between FXDY3 expression and clinicopathological features. FXYD3 expression was analyzed by streptavidin-peroxidase immunohistochemistry in 21 normal endometrial tissue samples, 18 atypical endometrial hyperplasia samples and 50 tissues obtained from patients diagnosed with endometrial cancer. The percentage of FXYD3-positive cell expression in the normal endometrium, atypical hyperplasia and endometrial cancer tissues samples was 0, 22, and 26%, respectively. The differences between the atypical hyperplasia and endometrial cancer groups were statistically significant when compared with the normal group (P=0.007 and P=0.037, respectively). There was no significant difference between the atypical hyperplasia and endometrial cancer groups. The percentage of FXYD3-positive cells correlated with the fertility frequency (Pless than0.05). In conclusion, FXYD3 is a potential biomarker for endometrial cancer, and its upregulation may be an early event in endometrial carcinoma progression. In addition, FXYD3 expression in endometrial carcinoma correlates with fertility frequency.
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| 4. |
- Luo, Hongzhen, et al.
(författare)
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Prediction of phenolic compounds and glucose content from dilute inorganic acid pretreatment of lignocellulosic biomass using artificial neural network modeling
- 2021
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Ingår i: Bioresources and Bioprocessing. - : Springer Science and Business Media Deutschland GmbH. - 2197-4365. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Dilute inorganic acids hydrolysis is one of the most promising pretreatment strategies with high recovery of fermentable sugars and low cost for sustainable production of biofuels and chemicals from lignocellulosic biomass. The diverse phenolics derived from lignin degradation during pretreatment are the main inhibitors for enzymatic hydrolysis and fermentation. However, the content features of derived phenolics and produced glucose under different conditions are still unclear due to the highly non-linear characteristic of biomass pretreatment. Here, an artificial neural network (ANN) model was developed for simultaneous prediction of the derived phenolic contents (CPhe) and glucose yield (CGlc) in corn stover hydrolysate before microbial fermentation by integrating dilute acid pretreatment and enzymatic hydrolysis. Six processing parameters including inorganic acid concentration (CIA), pretreatment temperature (T), residence time (t), solid-to-liquid ratio (RSL), kinds of inorganic acids (kIA), and enzyme loading dosage (E) were used as input variables. The CPhe and CGlc were set as the two output variables. An optimized topology structure of 6–12-2 in the ANN model was determined by comparing root means square errors, which has a better prediction efficiency for CPhe (R2 = 0.904) and CGlc (R2 = 0.906). Additionally, the relative importance of six input variables on CPhe and CGlc was firstly calculated by the Garson equation with net weight matrixes. The results indicated that CIA had strong effects (22%-23%) on CPhe or CGlc, then followed by E and T. In conclusion, the findings provide new insights into the sustainable development and inverse optimization of biorefinery process from ANN modeling perspectives. Graphical Abstract: [Figure not available: see fulltext.]. © 2021, The Author(s).
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| 5. |
- Wang, Zheng, et al.
(författare)
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Trade-off effect of hydrogen-bonded dopant-free hole transport materials on performance of inverted perovskite solar cells
- 2024
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Ingår i: Nano Energy. - 2211-2855. ; 128
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Tidskriftsartikel (refereegranskat)abstract
- Benefiting from their ordered orientation and superior stability compared to traditional conjugated materials, hydrogen bonding (HB)-induced H-aggregates in organic small molecule hole-transport materials (HTMs) hold a big potential for high-performance inverted perovskite solar cells (IPSCs). However, H-aggregates can also lead to excessive face-aggregation by forming the gaps between aggregates, which is in turn unfavorable for charge mobility and thus for the overall device performance. Herein, we design and synthesize a new set of HB-containing triphenylamine-based small molecules to tailor the degree of H-aggregation, namely O1 (without HB), O2 (unilateral HB unit), and O3 (bilateral HB units). These HTMs make a clear trade-off effect on the charge mobility within the HTM and the interfacial properties of perovskite and HTM. Although the interfacial hole extraction process is promoted upon the HB-functionalized interface, the best performance of IPSCs is still achieved by O1 HTM, which is mainly influenced by the higher hole mobility without HB-induced H-aggregates. Nevertheless, the photo stability of as-fabricated devices is effectively improved upon the HB passivation effect on the interface of HTM (O2 or O3) and perovskite, as well as the better quality of atop perovskite layers with less grain boundary compared to the reference case (O1).
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| 6. |
- Wu, Xiujuan, et al.
(författare)
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Exploration of electrocatalytic water oxidation properties of NiFe catalysts doped with nonmetallic elements (P, S, Se)
- 2021
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Ingår i: International journal of hydrogen energy. - : Elsevier BV. - 0360-3199 .- 1879-3487. ; 46:79, s. 38992-39002
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Tidskriftsartikel (refereegranskat)abstract
- The introduction of non-metallic atoms (P, S, Se) has emerged as an effective way to improve the catalytic activity of transition metal based layered double hydroxides (LDHs) for oxygen evolution reaction. However, objective comparisons of the performance of heteroelement-doped catalysts are complicated by the lack of standardization both in the electrochemical tests and physicochemical analysis. Herein, we use a unified protocol for evaluating the catalytic activities of heteroelement-doped NiFe-LDHs and explore the reasons for the differences in their catalytic performance. Some regular results are found from comparing the properties of the heteroelement-doped catalysts: (1) the introduction of P/S/Se can optimize the redox behaviors of Ni species, which is conducive to regulating adsorption energy of intermediates and the formation of high-valent active sites; (2) the specific area of catalysts was expanded after heteroelements doping, ensuring a more favorable structure for heterogeneous catalysis; (3) All P/S/Se-doped catalysts showed better activities when compared to the original NiFe LDHs in alkaline solutions, and the catalysts doped with S showed the best performance (Se < P < S).
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| 7. |
- Wu, Xiujuan, et al.
(författare)
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Metalloid Te-Doped Fe-Based Catalysts Applied for Electrochemical Water Oxidation
- 2021
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Ingår i: CHEMISTRYSELECT. - : Wiley. - 2365-6549. ; 6:24, s. 6154-6158
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Tidskriftsartikel (refereegranskat)abstract
- Metal telluride nanocatalysts have been widely used in the catalytic reactions. However, there are few examples of electrocatalytic water oxidation with metal telluride as catalysts, especially Fe-based telluride, to the best of our knowledge, has not yet been reported. In this work, the Te-doped Fe-based catalysts (FeTex) with crystalline and amorphous nanosheet structures have been successfully synthesized by chemical vapor deposition (CVD) as well as electrodeposition (ED) on the iron foam (IF), where the latter exhibited more remarkable electrocatalytic performance towards the oxygen evolution reaction (OER) in the alkaline electrolyte, requiring the overpotential (eta) of only 264.4 mV to reach a current density of 10 mA cm(-2) with a Tafel slope of 54.2 mV dec(-1). The electrochemical study confirmed that the residual Te in ED-FeTex does play a role in promoting the catalytic activity for the electrocatalytic water oxidation.
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| 8. |
- Wu, Xingqiang, et al.
(författare)
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NiCo/Ni/CuO nanosheets/nanowires on copper foam as an efficient and durable electrocatalyst for oxygen evolution reaction
- 2020
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Ingår i: International journal of hydrogen energy. - : Elsevier BV. - 0360-3199 .- 1879-3487. ; 45:41, s. 21354-21363
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Tidskriftsartikel (refereegranskat)abstract
- Electrochemical water splitting for hydrogen production is a promising solution for the production of renewable and environmentally friendly energy sources, but it is hindered by the sluggish kinetic process of oxygen evolution reaction (OER). Here, a novel hierarchical core-shell nanoarray NiCo/Ni/CuO/CF was synthesized by assembling Ni-Co hydroxide nanosheets directly on the metallic nickel coated CuO nanowires, as a highly efficient electrocatalyst for alkaline OER. This NiCo/Ni/CuO/CF anode exhibited low overpotentials of 246 mV and 286 mV at current densities of 10 mA cm(-2) and 100 mA cm(-2), respectively, and a small Tafel slope of 37.9 mV dec(-1). Moreover, NiCo/Ni/CuO/CF showed robust durability at least 60 h at a current density of 100 mA cm(-2). Detailed investigations verified that the unique nanosheets/nanowires architecture with high conductivity metallic nickel layer can expand the exposure of active sites and accelerate the transport of electrons.
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| 9. |
- Ye, Qilun, et al.
(författare)
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Urchin-Like Cobalt-Copper (Hydr)oxides as an Efficient Water Oxidation Electrocatalyst
- 2020
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Ingår i: ChemPlusChem. - : Wiley. - 2192-6506. ; 85:6, s. 1339-1346
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Tidskriftsartikel (refereegranskat)abstract
- The development of e & xfb03;cient and low-cost oxygen evolution reaction (OER) catalysts is essential for the generation of clean hydrogen energy from water splitting. Herein, a novel hierarchical urchin-like cobalt-copper (hydr)oxide in situ grown on copper foam (CoCuOxHy(S)/CF) was synthesized through the electrochemical transformation of cobalt-copper sulfides (Co9S8-Cu1.81S) via anodization process. This CoCuOxHy(S)/CF anode exhibited a low overpotential (eta) of 274 mV at a current density of 100 mA cm(-2)with a robust durability over a period of 40 h when operated at 10 mA cm(-2). Further investigations imply that the unique nanowires aggregated urchin-like structure of CoCuOxHy(S) derived from the in situ anion exchange process could facilitate the exposure of active sites and accelerate electron transfer. More importantly, the incorporation of copper resulted in an electronic delocalization around the cobalt species, which contributed to reach a high-valent catalytically active cobalt species and further improved the OER performance.
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