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- Morales, J. C., et al.
(författare)
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A giant exoplanet orbiting a very-low-mass star challenges planet formation models
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 365:6460, s. 1441-1445
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Tidskriftsartikel (refereegranskat)abstract
- Surveys have shown that super-Earth and Neptune-mass exoplanets are more frequent than gas giants around low-mass stars, as predicted by the core accretion theory of planet formation. We report the discovery of a giant planet around the very-low-mass star GJ 3512, as determined by optical and near-infrared radial-velocity observations. The planet has a minimum mass of 0.46 Jupiter masses, very high for such a small host star, and an eccentric 204-day orbit. Dynamical models show that the high eccentricity is most likely due to planet-planet interactions. We use simulations to demonstrate that the GJ 3512 planetary system challenges generally accepted formation theories, and that it puts constraints on the planet accretion and migration rates. Disk instabilities may be more efficient in forming planets than previously thought.
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- Aguilar-Vazquez, A, et al.
(författare)
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Impaired muscle strength is associated with ultrastructure damage in myositis
- 2022
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1, s. 17671-
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Tidskriftsartikel (refereegranskat)abstract
- The muscle fiber ultrastructure in Idiopathic Inflammatory Myopathies (IIM) has been scarcely explored, especially in Inclusion Body Myositis. The aim of this study was to implement the Scanning Electron Microscopy (SEM) in a small cohort of IIM patients, together with the characterization of immunological profile for a better understanding of the pathophysiology. For immunological profile characterization, we identified the presence of autoantibodies (Ro-52, OJ, EJ, PL7, PL12, SRP, Jo-1, PMScl75, PMScl100, Ku, SAE1, NXP2, MDA5, TIF1γ, Mi-2α, Mi-2β) and quantified cytokines (IL-1β, IFN-α2, IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33) and chemokines (CCL2, CXCL8). The histological analysis was made by hematoxylin–eosin staining while the muscle fiber ultrastructure was characterized by SEM. We observed changes in the morphology and structure of the muscle fiber according to muscle strength and muscle enzymes. We were able to find and describe muscle fiber ultrastructure with marked irregularities, porosities, disruption in the linearity and integrity of the fascicle, more evident in patients with increased serum levels of muscle enzymes and diminished muscle strength. Despite the scarce reports about the use of SEM as a tool in all clinical phenotypes of IIM, our work provides an excellent opportunity to discuss and reframe the clinical usefulness of SEM in the diagnostic approach of IIM.
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- Parareda, S., et al.
(författare)
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Effect of heat treatment conditions on the fatigue resistance of press hardened 22MnB5 steel evaluated through rapid testing technique
- 2021
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Konferensbidrag (refereegranskat)abstract
- Fatigue strength is considered as a crucial parameter for automotive applications subjected to cyclic loads during their long service life, as chassis parts. The high yield stress of press hardened steels poses them as good candidates for lightweight solutions with improved fatigue resistance. However, their high strength leads to an increase in notch sensitivity which can ruin the whole part's integrity. This behaviour was observed in previous works on press hardened steels, where their high fatigue strength was significantly affected by the surface conditions and by heat treatment conditions. Nevertheless, press hardening steels are still good candidates to manufacture complex geometry parts reaching high performance.Aiming at increasing the existing knowledge on the fatigue behaviour of press hardened steels, this paper analyses the fatigue performance of boron steel (22MnB5) under different time austenitizing times. Fatigue resistance is evaluated using a novel rapid fatigue testing technique based on the stiffness evolution. The method permits a fast and reliable determination of the fatigue limit. Based on results obtained with this rapid testing method, the most suitable heat treatment to mitigate fatigue notch sensitivity and then achieving the best fatigue performance for chassis applications is discussed.
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