| 1. |
- Wijns, W, et al.
(författare)
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Myocardial revascularization
- 2011
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Ingår i: REVISTA PORTUGUESA DE CARDIOLOGIA. - : Elsevier BV. - 0870-2551 .- 2174-2049. ; 30:12, s. 951-1005
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Fieblinger, T., et al.
(författare)
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Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats
- 2018
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Dendritic regression of striatal spiny projection neurons (SPNs) is a pathological hallmark of Parkinson's disease (PD). Here we investigate how chronic dopamine denervation and dopamine replacement with L-DOPA affect the morphology and physiology of direct pathway SPNs (dSPNS) in the rat striatum. We used a lentiviral vector optimized for retrograde labeling (FuG-B-GFP) to identify dSPNs in rats with 6-hydroxydopamine (6-OHDA) lesions. Changes in morphology and physiology of dSPNs were assessed through a combination of patch-clamp recordings and two photon microscopy. The 6-OHDA lesion caused a significant reduction in dSPN dendritic complexity. Following chronic L-DOPA treatment, dSPNs segregated into two equal-sized clusters. One group (here called "cluster-1"), showed sustained dendritic atrophy and a partially normalized electrophysiological phenotype. The other one ("cluster-2") exhibited dendritic regrowth and a strong reduction of intrinsic excitability. Interestingly, FosB/ΔFosB induction by L-DOPA treatment occurred preferentially in cluster-2 dSPNs. Our study demonstrates the feasibility of retrograde FuG-B-GFP labeling to study dSPNs in the rat and reveals, for the first time, that a subgroup of dSPNs shows dendritic sprouting in response to chronic L-DOPA treatment. Investigating the mechanisms and significance of this response will greatly improve our understanding of the adaptations induced by dopamine replacement therapy in PD.
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| 6. |
- Lockowandt, C., et al.
(författare)
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The stratospheric balloon mission PoGO+ from Esrange to Victoria Island, Canada
- 2017
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Ingår i: AIAA Balloon Systems Conference, 2017. - Reston, Virginia : American Institute of Aeronautics and Astronautics.
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Konferensbidrag (refereegranskat)abstract
- PoGO is a stratospheric balloon project with a cosmic ray experiment from KTH, Stockholm, Sweden. The PoGO+ mission was launched on July 12th, 2016 for a 7 day flight from Sweden to Canada. The payload mass was 1728 kg and an Aerostar SF-39.57 balloon was used to reach the float altitude of 40 km. In 2013 a similar experiment flew from Esrange to Norilsk in Russia in a circumpolar flight that lasted 2 weeks. That balloon mission was called PoGOLite. The experiment on PoGO+ was a balloon-borne hard X-ray polarimeter operating in the 25 - 240 keV energy band from a stabilized observation platform. Observations were conducted from a stabilized stratospheric balloon platform at an altitude of approximately 40 km. The primary targets were the Crab - a pulsar and associated wind nebula in the constellation of Taurus, 6500 light years from Earth, and Cygnus X-1 - a black hole binary system. A custom attitude control system kept the polarimeter field-of-view aligned to targets of interest, compensating for sidereal motion and perturbations such as torsional forces in the balloon rigging. After a launch at 03:17 UTC, the balloon reached float altitude after more than 5 hours, due to a cold stratosphere with slow ascent. A slower than anticipated wind took the balloon over the Atlantic for a landing in Canada on July 18th at 22:26 UTC. Landing latitude was 71.84747 N, longitude 110.885 E on Victoria Island. The mission was very successful with all systems both scientific and support and balloon systems working nominal during the complete flight. A huge amount of scientific data was collected during the flight that are analyzed. The landing and recovery was performed nominal and the scientific data were recovered and delivered to the science team within 12 days after landing. The mission was managed by SSC and SSC was also responsible for the gondola structure, housekeeping and communication systems, power systems and of the balloon flight systems. SSC was handling the launch, flight and recovery operations. KTH was responsible for the instrument, X-ray polarimeter, including all subsystems for controlling and monitoring the systems including thermal management. DST Control was responsible for the dual axis pointing system. New Mexico State University, USA, was delivering part of the balloon flight systems.
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| 7. |
- Nashef, SAM, et al.
(författare)
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EuroSCORE II
- 2012
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Ingår i: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. - : Oxford University Press (OUP). - 1873-734X. ; 41:4, s. 734-745
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Tidskriftsartikel (refereegranskat)
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| 8. |
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| 10. |
- Pecz, B, et al.
(författare)
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Structural investigation of SiC epitaxial layers grown under microgravity and on-ground conditions
- 1999
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Ingår i: Thin Solid Films. - 0040-6090 .- 1879-2731. ; 357:2, s. 137-143
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Tidskriftsartikel (refereegranskat)abstract
- Thick 4H-, and 6H-SiC epitaxial layers have been grown by LPE from Si-Sc-C solvent at microgravity conditions during a space experiment, as well as on-ground. The samples are characterised by cross-sectional TEM and HRXRD. Layers grown at microgravity are relatively defect free, although their surfaces are always stepped. Control samples grown on-ground have similar surface appearance, but contain scandium carbide precipitates, nanopipes, micropipes and/or cavities as verified by TEM. However, none of the aforementioned defects was traced in the layers grown at microgravity conditions. So, samples grown at space microgravity conditions are superior in their defect structure to those ones grown on the ground. The defects called nanopipes can be described as empty pipes of about 200 nm diameter traversing the layer in the [0001] (growth) direction. The steps in the microgravity and on-ground samples have facets of {104} type crystallographic planes both in 6H-, and 4H-SiC. We suggest, that those facets are formed and preferred during growth due to a possible mechanism of decreasing the high energy of the growing Si terminated (0001) surface. (C) 1999 Elsevier Science S.A. All rights reserved.
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| 11. |
- Pecz, B, et al.
(författare)
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Structure of SiC layers grown by LPE in microgravity and on-ground conditions
- 1999
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Ingår i: Institute of Physics Conference Series. - 0951-3248 .- 2154-6630. ; :164, s. 243-246
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Tidskriftsartikel (refereegranskat)abstract
- High quality, hexagonal SiC layers have been grown in microgravity conditions and on-ground as well. The surface of the layers is always stepped. The dislocation density of the layers is increased closer to the surface. Scandium carbide precipitates, nanopipes and cavities were found in the SiC layers grown on-ground, but none of them were traced in the layers grown under microgravity conditions.
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| 12. |
- Yakimova, R, et al.
(författare)
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Silicon carbide grown by liquid phase epitaxy in microgravity
- 1998
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Ingår i: Journal of Materials Research. - 0884-2914 .- 2044-5326. ; 13, s. 1812-1815
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Tidskriftsartikel (refereegranskat)abstract
- 6H and 4H polytype silicon carbide (SiC) layers have been grown on ground and under microgravity conditions by liquid phase epitaxy (LPE) from a solution of SiC in Si-Se solvent at 1750 degrees C. The effects of gravity on the growth parameters and material characteristiques have been studied. The growth rate, Sc incorporation, and the structural defects are modified in reduced gravity conditions, while the polytype reproduction of the substrate is not affected. The results obtained are intriguing as to further experiments providing objects for carrier lifetime measurements.
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