SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lofman Owe) "

Sökning: WFRF:(Lofman Owe)

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Helmfrid, Ingela, et al. (författare)
  • Health effects and exposure to polychlorinated biphenyls (PCBs) and metals in a contaminated community
  • 2012
  • Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 44, s. 53-58
  • Tidskriftsartikel (refereegranskat)abstract
    • Environmental measurements carried out by local authorities during the 1970s, 80s and 90s in an area contaminated by hundreds of years of industrial activities have revealed high levels of zinc (Zn), copper (Cu), lead (Pb) and cadmium (Cd) in soil, vegetables, root crops, berries and mushrooms. In 1972, a large quantity of oil contaminated with polychlorinated biphenyls (PCBs) was accidentally spilled into the river running through the village. To investigate the possible health effects of exposure from local sources, all cancer diagnoses, registered in 1960-2003 for individuals living in the study area, were collected from the regional cancer register of southeast Sweden. The total cancer incidence was non-significantly decreased both among males and females as compared to national rates (SIR = 0.91) for each gender. Among males, increased risks, of border-line significance, were seen for testicular cancer and lymphomas as well as significantly decreased risks for cancer in the rectum, respiratory system and brain. Information on lifetime residence, occupation, smoking habits, diseases, childbirth and food consumption, was collected via questionnaires from cancer cases and randomly selected controls. In both genders combined, significant associations were found for total cancer and high consumption of local perch, and for lymphomas and high consumption of both perch and pikeperch. Female breast cancer was significantly associated with high consumption of local perch and pike as well as with work in metal production. Mothers residing in the parish before the age of five reported significantly more preterm child deliveries. In spite of study limitations, the results indicate that residing in a rural contaminated area may contribute to the development of certain cancers and reproductive effects. In females, high consumption of local fish was shown to be the strongest determinant for total cancer, while in males, the strongest determinant was residing in the study area the first five years of life. Further research including validation of exposure using biomarkers is required to verify the findings as well as future studies in other polluted areas in Sweden with larger population bases.
  •  
2.
  •  
3.
  • Sandblom, Gabriel, et al. (författare)
  • Randomised prostate cancer screening trial: 20 year follow-up
  • 2011
  • Ingår i: BRITISH MEDICAL JOURNAL. - : B M J PUBLISHING GROUP, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND. - 0959-535X. ; 342:d1539
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective To assess whether screening for prostate cancer reduces prostate cancer specific mortality. Design Population based randomised controlled trial. Setting Department of Urology, Norrkoping, and the South-East Region Prostate Cancer Register. Participants All men aged 50-69 in the city of Norrkoping, Sweden, identified in 1987 in the National Population Register (n=9026). Intervention From the study population, 1494 men were randomly allocated to be screened by including every sixth man from a list of dates of birth. These men were invited to be screened every third year from 1987 to 1996. On the first two occasions screening was done by digital rectal examination only. From 1993, this was combined with prostate specific antigen testing, with 4 mu g/L as cut off. On the fourth occasion (1996), only men aged 69 or under at the time of the investigation were invited. Main outcome measures Data on tumour stage, grade, and treatment from the South East Region Prostate Cancer Register. Prostate cancer specific mortality up to 31 December 2008. Results In the four screenings from 1987 to 1996 attendance was 1161/1492 (78%), 957/1363 (70%), 895/1210 (74%), and 446/606 (74%), respectively. There were 85 cases (5.7%) of prostate cancer diagnosed in the screened group and 292 (3.9%) in the control group. The risk ratio for death from prostate cancer in the screening group was 1.16 (95% confidence interval 0.78 to 1.73). In a Cox proportional hazard analysis comparing prostate cancer specific survival in the control group with that in the screened group, the hazard ratio for death from prostate cancer was 1.23 (0.94 to 1.62; P=0.13). After adjustment for age at start of the study, the hazard ratio was 1.58 (1.06 to 2.36; P=0.024). Conclusions After 20 years of follow-up the rate of death from prostate cancer did not differ significantly between men in the screening group and those in the control group.
  •  
4.
  • Tondel, Martin, 1962, et al. (författare)
  • Risk of malignancies in relation to terrestrial gamma radiation in a Swedish population cohort
  • 2011
  • Ingår i: SCIENCE OF THE TOTAL ENVIRONMENT. - : Elsevier Science B.V., Amsterdam.. - 0048-9697 .- 1879-1026. ; 409:3, s. 471-477
  • Tidskriftsartikel (refereegranskat)abstract
    • Results of epidemiological studies on terrestrial gamma radiation (TGR) and related malignancies have not been consistent. This study is a thorough examination of this relationship. Records on all individuals living in two Swedish counties in 1973, along with their annual dwelling coordinates during the 28-year follow-up period, were retrieved from the National Archives and Statistics Sweden. We used Geographical Information System (GIS) to match the individuals dwelling coordinates annually to the TGR given in 200 x 200 m grids produced by the Geological Survey of Sweden. Cases of malignancies and deaths were retrieved from the Swedish Cancer Register. During the follow-up period 61,503 incident cases were included in the analyses and in total 11 million person-years were recorded. Cox regression was used both in a linear continuous model and analyses of six exposure categories. Adjustments were made for sex, age, and population density. The hazard ratio (HR) per 100 nanoGray/hour (nGy/h) was significantly increased for total malignancies and for several sites: however, contrary to expectations, an obvious and anticipated linear exposure-response relationship could not be identified. With the lowest exposure category (0-60 nGy/h) as reference, a statistically significantly increased HR for total malignancies was seen in all exposure categories, except in the highest category 96-366 nGy/h. For breast cancer, thyroid cancer and leukaemia an obvious exposure-response could not be seen.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy