| 1. |
- Deubner, Nikolas, et al.
(författare)
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Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study.
- 2010
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Ingår i: European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology. - : Wiley. - 1879-0844. ; 12:7, s. 753-62
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Tidskriftsartikel (refereegranskat)abstract
- Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot studies have shown their prognostic significance in human 'idiopathic' cardiomyopathy.
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| 2. |
- Geijer, Håkan, 1961-, et al.
(författare)
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Temperature measurements with a temporal scanner : systematic review and meta-analysis
- 2016
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Ingår i: BMJ Open. - London, United Kingdom : BMJ Group. - 2044-6055. ; 6:3
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Forskningsöversikt (refereegranskat)abstract
- Objectives: Systematic review and meta-analysis on the diagnostic accuracy of temporal artery thermometers (TAT).Design: Systematic review and meta-analysis. The index test consisted of temperature measurement with TAT. The reference test consisted of an estimation of core temperature.Participants: Clinical patients as well as healthy participants, with or without fever.Interventions: Literature search in PubMed, Embase, Cinahl and Web of Science. Three reviewers selected articles for full-text reading after which a further selection was made. Risk of bias was assessed with QUADAS-2. Pooled difference and limits of agreement (LoA) were estimated with an inverse variance weighted approach. Subgroup and sensitivity analyses were performed. Sensitivity and specificity were estimated using hierarchical models. Quality of evidence was assessed according to the GRADE system.Primary and secondary outcome measures: The primary outcome was measurement accuracy expressed as mean difference ±95% LoA. A secondary outcome was sensitivity and specificity to detect fever. If tympanic thermometers were assessed in the same population as TAT, these results were recorded as well.Results: 37 articles comprising 5026 participants were selected. Pooled difference was -0.19°C (95% LoA -1.16 to 0.77°C), with moderate quality of evidence. Pooled sensitivity was 0.72 (95% CI 0.61 to 0.81) with a specificity of 0.94 (95% CI 0.87 to 0.97). The subgroup analysis revealed a trend towards underestimation of the temperature for febrile patients. There was a large heterogeneity among included studies with wide LoA which reduced the quality of evidence.Conclusions: TAT is not sufficiently accurate to replace one of the reference methods such as rectal, bladder or more invasive temperature measurement methods. The results are, however, similar to those with tympanic thermometers, both in our meta-analysis and when compared with others. Thus, it seems that TAT could replace tympanic thermometers with the caveat that both methods are inaccurate.Trial registration number: CRD42014008832.
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| 4. |
- Jansson, Stefan P. O., 1959-, et al.
(författare)
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Interventions for lifestyle changes to promote weight reduction, a randomized controlled trial in primary health care
- 2013
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Ingår i: BMC Research Notes. - UK : BioMed Central Ltd.. - 1756-0500. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Overweight and obesity are growing public health problems in high income countries and is now growing at a dramatic pace in low and middle income countries, particularly in urban settings. The aim of this trial was to examine the effects of a weight reduction program in adults and to determine whether or not a more extensive intervention was superior to ordinary care.Methods: Patients seeking advice for overweight/obesity or illness related to overweight/obesity at eight primary health care centers in Sweden were randomized either to intervention or control care groups with both groups given dietary advice and individualized information on increased regular physical activity. In the intervention group advice was more extensive and follow-up more frequent than in the control group during the study period of two years. Main outcome measure was reduction in body weight of five percent or more from study start.Results: From October 2004 to April 2006, 133 patients, 67 in the intervention group and 66 in the control group, were randomized over a period of 18 months. Target weight was achieved at 12 months by 26.7% of the patients in the intervention group compared with 18.4% in the control group (p = 0.335). There was an average absolute weight loss of 2.5 kg in the intervention group and 0.8 kg in the control group at 12 months as compared with the weight at study entry. There were no significant differences between the groups in quality of life, blood glucose and lipids. At 24 months target weight was achieved in 21.9% versus 15.6%, with an average weight reduction of 1.9 kg and 1.2 kg in the two groups, respectively.Conclusions: Promotion of a diet with limited energy intake, appropriate composition of food and increased physical activity had limited effects on body weight in a Swedish primary care setting. More extensive advice and more frequent visits made no significant difference to the outcome.
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| 5. |
- Nilsagård, Ylva, et al.
(författare)
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Evidence-based physiotherapy: A survey of knowledge, behaviour, attitudes and prerequisites
- 2010
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Ingår i: Advances in Physiotherapy. - : Informa UK Limited. - 1403-8196 .- 1651-1948. ; 12:4, s. 179-186
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Tidskriftsartikel (refereegranskat)abstract
- The purpose was to describe knowledge, attitude, behaviour, and prerequisites regarding evidence-based physiotherapy(EBPT) and to evaluate potential differences related to employment sectors and levels of education. A cross-sectional studywas conducted using a web-based questionnaire to a random sample of 2,160 physiotherapists (PTs). Self-rated knowledgeof evidence-based medicine (EBM) was rather high (median69; IQ1;IQ3 50 – 77), although only 12 – 36% correctly identified all EBM components. Approximately 70% reported good ability to formulate clinical questions and critically appraisescientifi c literature. Only 28% performed database searches weekly or monthly. Eighty-six per cent reported using evidencebasedguidelines in clinical practice. Lack of time (86%), advisors (80%), knowledge (55%) and superiors ’ lack of interestin EBM (46%) were common barriers. EBM was considered important (median82, IQ1;IQ3 75 – 91) and believed toimprove the quality of care (median80, IQ1;IQ3 74 – 90). Employment sector differences were most obvious for behaviourand prerequisites with a disadvantage for municipality-employed PTs. The higher the level of education, the greater theknowledge, the more positive the attitudes, the better the prerequisites and the fewer the barriers reported.
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