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- Buondonno, A., et al.
(författare)
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A Hub and Spoke Learning Program in Bariatric Surgery in a Small Region of Italy
- 2022
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Ingår i: Frontiers in Surgery. - : Frontiers Media SA. - 2296-875X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundMetabolic and bariatric surgery (BS) are considered life-changing and life-saving treatments for obese patients. The Italian Society of Obesity Surgery (SICOB) requires at least 25 operations per year to achieve the standard of care in the field. Despite the increasing need to treat obese patients, some small southern regions of Italy, such as Molise, do not have enough experience in bariatric procedures to be allowed to perform them. Therefore, our aim was to run a Hub and Spoke Program with a referral center in BS to treat obese patients and provide a proper learning curve in BS in Molise. MethodsIn 2020, the "A. Cardarelli Hospital" in Campobasso, Molise, started a formal "Learning Model of Hub and Spoke Collaboration" with the Hub center "Ospedale Del Mare", Naples. A multidisciplinary approach was achieved. Patients were supervised and operated under the supervision and tutoring of the referral center. We retrospectively reviewed our prospectively collected database from February 2020 to August 2021 in order to analyze the safety and effectiveness of our learning program. ResultsIn total, 13 (3 men and 10 women) patients underwent BS with the mean age of 47.08 years and a presurgery BMI of 41.79. Seven (53.84%) patients were the American Society of Anesthesiologist (ASA) II, and 6 (46.16%) patients were ASA III. Twelve (92.31%) procedures were laparoscopic sleeve gastrectomies, 1 (7.69%) patient underwent endoscopic BioEnterics Intragastric Balloon (BIB) placement. One (8.33%) sleeve gastrectomy was associated to gastric band removal. Mean surgical time was 110.14 +/- 23.54 min. The mean length of stay was 4.07 +/- 2.40 days. No Clavien-Dindo >= III and mortality were reported. The follow-up program showed a mean decrease of 11.82 in terms of body mass index (BMI) value. The last 5 procedures were performed by the whole equips from "A. Cardarelli" under external tutoring without any impact on complication rate. ConclusionThe setup of a proper Hub and Spoke Program may allow to perform BS to provide the standard of care. This approach may reduce health costs and related patient migration.
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- El-Gebali, Sara, et al.
(författare)
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The Pfam protein families database in 2019
- 2019
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 47:D1, s. D427-D432
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Tidskriftsartikel (refereegranskat)abstract
- The last few years have witnessed significant changes in Pfam (https://pfam.xfam.org). The number of families has grown substantially to a total of 17,929 in release 32.0. New additions have been coupled with efforts to improve existing families, including refinement of domain boundaries, their classification into Pfam clans, as well as their functional annotation. We recently began to collaborate with the RepeatsDB resource to improve the definition of tandem repeat families within Pfam. We carried out a significant comparison to the structural classification database, namely the Evolutionary Classification of Protein Domains (ECOD) that led to the creation of 825 new families based on their set of uncharacterized families(EUFs). Furthermore, we also connected Pfam entries to the Sequence Ontology (SO) through mapping of the Pfam type definitions to SO terms. Since Pfam has many community contributors, we recently enabled the linking between authorship of all Pfam entries with the corresponding authors' ORCID identifiers. This effectively permits authors to claim credit for their Pfam curation and link them to their ORCID record.
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- Del Curto, D., et al.
(författare)
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Energy efficiency and preservation of 20th century architecture : The case of the Urbino University Colleges
- 2018
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Ingår i: Conference Report. - : Uppsala University. ; , s. 401-412
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Konferensbidrag (refereegranskat)abstract
- This paper follows the discussion on the energy efficiency of heritage buildings by dealing with the task of preserving 20th century buildings and making them more sustainable. It is confirmed that a thorough analysis of each case is needed, since the cultural value of modern heritage risks being overwhelmed by the effort to improve its energy efficiency. The Urbino University Colleges are a masterpiece of the 20th century. They were designed by architect Giancarlo de Carlo, built between 1962 and 1983 and still host 1000 students. A conservation plan was outlined in 2016 with the aim of developing the long-term and sustainable preservation of such a huge complex. A specific goal in terms of sustainability was lowering the heating costs to save funds for conservation activities. The efforts were thus to balance building conservation, energy efficiency and users’ comfort. A thermal analysis, an energy retrofit design, a test on a pilot site, a comparison between before and after, are the tools that have been used to achieve this objective. Results provide some operational indications to merge conservation and sustainability in a 20th century heritage building.
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- Guellil, Meriam, et al.
(författare)
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A genomic and historical synthesis of plague in 18th century Eurasia.
- 2020
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 117:45, s. 28328-28335
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Tidskriftsartikel (refereegranskat)abstract
- genomes from nine individuals covering four Eurasian sites and placed them into an historical context within the established phylogeny. CHE1 (Chechnya, Russia, 18th century) is now the latest Second Plague Pandemic genome and the first non-European sample in the post-Black Death lineage. Its placement in the phylogeny and our synthesis point toward the existence of an extra-European reservoir feeding plague into Western Europe in multiple waves. By considering socioeconomic, ecological, and climatic factors we highlight the importance of a noneurocentric approach for the discussion on Second Plague Pandemic dynamics in Europe.
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