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Sökning: WFRF:(Lukehart Sheila A)

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1.
  • Roberts, Frank A, et al. (författare)
  • Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.
  • 2004
  • Ingår i: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 72:2, s. 1166-1168
  • Tidskriftsartikel (refereegranskat)abstract
    • Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.
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2.
  • Currier, Russell W, et al. (författare)
  • The evolution of infectious agents in relation to sex in animals and humans: brief discussions of some individual organisms.
  • 2011
  • Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 1749-6632 .- 0077-8923. ; 1230, s. 74-107, s. 74-107
  • Forskningsöversikt (refereegranskat)abstract
    • The following series of concise summaries addresses the evolution of infectious agents in relation to sex in animals and humans from the perspective of three specific questions: (1) what have we learned about the likely origin and phylogeny, up to the establishment of the infectious agent in the genital econiche, including the relative frequency of its sexual transmission; (2) what further research is needed to provide additional knowledge on some of these evolutionary aspects; and (3) what evolutionary considerations might aid in providing novel approaches to the more practical clinical and public health issues facing us currently and in the future?
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