| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Dahlstedt, Magnus, et al.
(författare)
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Inledning : Förhandlingar och spänningsfält
- 2023
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Ingår i: De sociala rättigheternas politik. - 9789151109855 ; , s. 9-9
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Det sociala arbetets praktik handlar om att ge hjälp och stöd och förhindra exkludering och främja delaktighet. Socialt arbete handlar till stor del om att tillämpa befintliga lagar utifrån det tolkningsutrymme som finns. I varje enskilt fall vägs en rad individuella omständigheter samman med tolkningar av denna lagstiftning. Det är bl.a. inom ramen för detta handlingsutrymme som de sociala rättigheterna görs tillgängliga och blir till. Därför har kopplingen mellan rättigheter och socialt arbete stor betydelse för det sociala arbetet, både som praktik och som forskningsfält. I den här antologin riktar författarna uppmärksamhet mot sociala rättigheter utifrån olika teoretiska infallsvinklar, metoder och empiriska fokuspunkter. Med stöd i exempel från en svensk kontext behandlar författarna tolkning och tillämpning av sociala rättigheter. Hur får de olika innebörder beroende på vilket system som ska säkerställa dem? Hur återskapas de och ges delvis nytt innehåll när en domstol uttolkar ett begrepp? Bokens avslutande kapitel handlar om förhandlingar om olika sociala rättigheter, t.ex. rätten till meningsfulla fritidsaktiviteter för barn och unga med intellektuell funktionsnedsättning, ansvar och rätten till vård och omsorg när det gäller anhörigvård samt rätten till språkutbildning för nyanlända. Magnus Dahlstedt (red.) är professor i socialt arbete vid Linköpings universitet. Hans forskning rör frågor om välfärd och medborgarskapande, med särskilt fokus på unga, inkludering och exkludering i migrationens tid. Anna Lundberg (red.) är professor i välfärdsrätt vid Linköpings universitet och professor i rättssociologi vid Lunds universitet. Hennes forskning rör rätten och välfärden i migrationens tidsålder med särskilt fokus på rättigheter. Dimitris Michailakis (red.) är professor emeritus i socialt arbete vid Linköpings universitet. Hans forskning är inriktad mot exkluderingsmekanismer i det moderna samhället och politisk styrning.Kristin Alfredsson Ågren är universitetslektor i arbetsterapi vid Linköpings universitet. David Ekholm är docent och universitetslektor i socialt arbete vid Centrum för kommunstrategiska studier, Linköpings universitet. Erik Eriksson är doktor i socialt arbete och verksam vid Socialhögskolan på Lunds universitet. Marie Gustavsson är universitetslektor i socialt arbete vid Linköpings universitet. Jenny My Johansson är doktorand i socialt arbete och adjunkt i välfärdsrätt vid Linköpings universitet. Pia Kjellbom är doktor i socialt arbete och verksam som lektor i välfärdsrätt vid Linköpings universitet. Anna Olaison är biträdande professor i socialt arbete vid Linköpings universitet. Sofia Nordmark är universitetslektor i sociologi vid socialt arbete, Linköpings universitet. Maria Persdotter är fil dr. i urbana studier och postdoktor i välfärdsrätt vid Linköpings universitet. Annika Taghizadeh Larsson är biträdande professor i socialt arbete vid Linköpings universitet. Viktor Vesterberg är universitetslektor i pedagogik vid Linköpings universitet. Veronika Wallroth är lektor i socialt arbete vid Linköpings universitet. Ulrika Wernesjö är universitetslektor i socialt arbete vid Linköpings universitet. Axel Ågren är lektor i socialt arbete vid Linköpings universitet. Johannes H. Österholm är universitetslektor i arbetsterapi vid Linköpings universitet.
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| 3. |
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| 4. |
- Kapferer-Seebacher, Ines, et al.
(författare)
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Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement
- 2016
-
Ingår i: American Journal of Human Genetics. - : Cell Press. - 0002-9297 .- 1537-6605. ; 99:5, s. 1005-1014
-
Tidskriftsartikel (refereegranskat)abstract
- Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal-dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, joint hypermobility, and mild skin findings. A locus was mapped to an approximately 5.8 Mb region at 12p13.1 but no candidate gene was identified. In an international consortium we recruited 19 independent families comprising 107 individuals with pEDS to identify the locus, characterize the clinical details in those with defined genetic causes, and try to understand the physiological basis of the condition. In 17 of these families, we identified heterozygous missense or in-frame insertion/deletion mutations in C1R (15 families) or C1S (2 families), contiguous genes in the mapped locus that encode subunits C1r and C1s of the first component of the classical complement pathway. These two proteins form a heterotetramer that then combines with six C1q subunits. Pathogenic variants involve the subunit interfaces or inter-domain hinges of C1r and C1s and are associated with intracellular retention and mild endoplasmic reticulum enlargement. Clinical features of affected individuals in these families include rapidly progressing periodontitis with onset in the teens or childhood, a previously unrecognized lack of attached gingiva, pretibial hyperpigmentation, skin and vascular fragility, easy bruising, and variable musculoskeletal symptoms. Our findings open a connection between the inflammatory classical complement pathway and connective tissue homeostasis.
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| 5. |
- Lundberg, Anna, et al.
(författare)
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De mänskliga rättigheternas framväxt
- 2023
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Ingår i: De sociala rättigheternas politik. - 9789151109855 ; , s. 49-49
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Det är viktigt att förstå att rättigheter kan etableras och utvecklas i en viss tid, för att i en annan tid utmanas, urholkas och ersättas av skyldigheter. Olika rättighetskategorier kan få olika tyngd i förhållande till varandra. Ett exempel belyses i detta kapitel, om de mänskliga rättigheternas framväxt i ett internationellt sammanhang. Bland annat behandlar kapitlet hur det kommer sig att ekonomiska och sociala rättigheter har fått en svagare ställning än politiska och medborgerliga rättigheter rent juridiskt. Skillnaden i juridisk tyngd mellan olika rättighetskategorier har på olika sätt betydelse för hur rättigheter institutionaliseras, och i förlängningen även för hur de används i det sociala arbetet och dess vardagliga praktik. Det är till exempel svårare att driva frågor i rättsliga processer som inte har en tydlig juridisk tyngd att falla tillbaka på.
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| 6. |
- Malmquist, Anna, et al.
(författare)
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Hbtq+ och psykologi i en historisk tillbakablick
- 2017
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Ingår i: HBTQ+ : Psykologiska perspektiv och bemötande - Psykologiska perspektiv och bemötande. - 9789127147430 ; , s. 13-34
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Bokkapitel (refereegranskat)abstract
- De individer, identiteter, uttryck och samlevnadsformer som idag kan sammanfogas under akronymen hbtq+ har genom historien betraktas på många olika vis. Psykologin har varit central för hur hbtq+ har förståtts, definierats och behandlats. I detta kapitel betraktas hbtq+historien därför med psykologiska glasögon.
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| 7. |
- Persdotter, Maria, et al.
(författare)
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Rätten till en skälig levnadsnivå i förhandling
- 2023
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Ingår i: De sociala rättigheternas politik. - 9789151109855 ; , s. 85-85
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Ett detta kapitel som behandlar sociala rättigheter i ett domstolssammanhang analyseras domstolars betydelsefulla roll när det gäller att uttolka och använda begreppet skälig levnadsnivå, som ett sätt att både omförhandla och utveckla rättigheter.
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| 8. |
- Semb, Gunvor, et al.
(författare)
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A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
- 2017
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Ingår i: Journal of Plastic Surgery and Hand Surgery. - : Taylor & Francis. - 2000-656X .- 2000-6764. ; 51:1, s. 2-13
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: Longstanding uncertainty surrounds the selection of surgical protocols for the closure of unilateral cleft lip and palate, and randomised trials have only rarely been performed. This paper is an introduction to three randomised trials of primary surgery for children born with complete unilateral cleft lip and palate (UCLP). It presents the protocol developed for the trials in CONSORT format, and describes the management structure that was developed to achieve the long-term engagement and commitment required to complete the project.METHOD: Ten established national or regional cleft centres participated. Lip and soft palate closure at 3-4 months, and hard palate closure at 12 months served as a common method in each trial. Trial 1 compared this with hard palate closure at 36 months. Trial 2 compared it with lip closure at 3-4 months and hard and soft palate closure at 12 months. Trial 3 compared it with lip and hard palate closure at 3-4 months and soft palate closure at 12 months. The primary outcomes were speech and dentofacial development, with a series of perioperative and longer-term secondary outcomes.RESULTS: Recruitment of 448 infants took place over a 9-year period, with 99.8% subsequent retention at 5 years.CONCLUSION: The series of reports that follow this introductory paper include comparisons at age 5 of surgical outcomes, speech outcomes, measures of dentofacial development and appearance, and parental satisfaction. The outcomes recorded and the numbers analysed for each outcome and time point are described in the series.TRIAL REGISTRATION: ISRCTN29932826.
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| 9. |
- Uhlén, Mathias, et al.
(författare)
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The human secretome
- 2019
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Ingår i: Science Signaling. - : American Association for the Advancement of Science (AAAS). - 1945-0877 .- 1937-9145. ; 12:609
-
Tidskriftsartikel (refereegranskat)abstract
- The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we present a comprehensive analysis of proteins predicted to be secreted in human cells, which provides information about their final localization in the human body, including the proteins actively secreted to peripheral blood. The analysis suggests that a large number of the proteins of the secretome are not secreted out of the cell, but instead are retained intracellularly, whereas another large group of proteins were identified that are predicted to be retained locally at the tissue of expression and not secreted into the blood. Proteins detected in the human blood by mass spectrometry-based proteomics and antibody-based immuno-assays are also presented with estimates of their concentrations in the blood. The results are presented in an updated version 19 of the Human Protein Atlas in which each gene encoding a secretome protein is annotated to provide an open-access knowledge resource of the human secretome, including body-wide expression data, spatial localization data down to the single-cell and subcellular levels, and data about the presence of proteins that are detectable in the blood.
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| 10. |
- Wernesjö, Ulrika, et al.
(författare)
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Omfördelning, erkännande, representation : – Nancy Frasers teori om rättvisa
- 2023
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Ingår i: De sociala rättigheternas politik. - 9789151109855 ; , s. 33-33
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Nancy Frasers arbete är ett exempel på kritik som en rad teoretiker har riktat mot Marshall, och inte minst mot hans förgivettagande att nationen är den givna ram inom vilken medborgarskap, det vill säga rättigheter av olika slag, anordnas och tillhandahålls. Även om vi i dag lever i en tid av globalisering och världsomspännande migration där rörlighet är mer regel än undantag, så är nationalismens ideal om tillhörighet till gemenskapen – grundad på kultu- rell homogenitet och enhetlighet – inte på något vis överspelade. Tvärtom lever sådana ideal fortfarande kvar, tas ofta för givna och är i många länder på frammarsch. Nationalstaten sätter på så sätt fortsatt prägel på samtida politiska debatter och bidrar på olika vis till att forma medborgarskap och dess rättigheter – både i Sverige och i många andra länder runt om i världen
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| 11. |
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| 12. |
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| 13. |
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| 14. |
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| 15. |
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| 16. |
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| 17. |
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| 18. |
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| 19. |
- Aspholm-Hurtig, Marina, et al.
(författare)
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Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
- 2004
-
Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5683, s. 519-22
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Tidskriftsartikel (refereegranskat)abstract
- Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.
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| 20. |
- Barbe, Laurent, et al.
(författare)
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Toward a confocal subcellular atlas of the human proteome
- 2008
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Ingår i: Molecular and cellular proteomics. - 1535-9476 .- 1535-9484. ; 7:3, s. 499-508
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Tidskriftsartikel (refereegranskat)abstract
- Information on protein localization on the subcellular level is important to map and characterize the proteome and to better understand cellular functions of proteins. Here we report on a pilot study of 466 proteins in three human cell lines aimed to allow large scale confocal microscopy analysis using protein-specific antibodies. Approximately 3000 high resolution images were generated, and more than 80% of the analyzed proteins could be classified in one or multiple subcellular compartment(s). The localizations of the proteins showed, in many cases, good agreement with the Gene Ontology localization prediction model. This is the first large scale antibody-based study to localize proteins into subcellular compartments using antibodies and confocal microscopy. The results suggest that this approach might be a valuable tool in conjunction with predictive models for protein localization.
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| 21. |
- Bexelius, Maria, et al.
(författare)
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27 forskare : Så kan EU:s murar rivas
- 2015
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Ingår i: Dagens samhälle. - : Sveriges kommuner och landsting. - 1652-6511. ; :20150923
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 22. |
- Bruce, Anna, et al.
(författare)
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Jämlikhet och icke-diskriminering
- 2010
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Ingår i: Mänskliga rättigheter : juridiska perspektiv - juridiska perspektiv. - 9789147090747
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 23. |
- Dåderman, Anna Maria, 1953-
(författare)
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Personality traits and psychopathy (PCL-R) in male juvenile delinquents
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Abstract State-administered correctional institutions in Sweden take care of approximately 600 juvenile delinquents every year. The treatment for these institutionalized young people is based mainly on environmental programs and milieu therapy.Fifty-six conduct-disordered juvenile delinquents (mean age 17 years) from four institutions were studied with respect to their personality traits, and the prevalence of psychopathy (measured by the Hare Psychopathy Checklist – Revised, PCL-R). One objective was to study the reliability and validity of commonly used personality inventories. In particular, the validity of psychopathy-related personality traits, included in Schalling’s psychopathy model (1978), was examined by studying the relationships between personality traits and psychopathy (PCL-R), the occurrence of previous treatment occasions, and relapse into crime. Four groups, the delinquent participants, a group of high sensation-seekers (air force pilot recruits), normal male adolescent participants, and another group of normal young males, completed a number of personality inventories, which enabled us to obtain measures of personality traits. The personality inventories used were the Karolinska Scales of Personality (KSP), the Eysenck Personality Questionnaire, and the Zuckerman Sensation-Seeking Scales. In addition, the delinquent participants were rated on psychopathy according to the modified version of the PCL-R, designed to be used with young people (Fort, Hart, & Hare, 1990). Both variable-oriented (factor analysis, MANOVA) and person-oriented statistical methods (cluster analysis) were applied.As expected, most personality traits in the delinquent participants deviated from published norms and from our control groups. The delinquent participants showed a high level of pathology or vulnerability for developing mental disorders (such as substance abuse). About 60% of the delinquent participants had scores above 30 on the PCL-R, and were thus classified as psychopaths according to the manual. Further, 73% had scores between 27 and 40, indicating a high level of psychopathy. Delinquent participants showed a different pattern of sensation-seeking behavior than air force pilot recruits and normal adolescent participants, and differed also in other personality traits. They had a low level of socialization, indicating a lack of ability to take the role of the generalized other, and a tendency to impulsiveness, somatic anxiety and extraversion-sociability. The construct validity (convergent and divergent) of the KSP scales was found to be adequate. Some of the personality traits in delinquent participants, however, showed a different correlation pattern than that found in noncriminal people. Some of the basic scales from the KSP had high reliability, but many were not reliable when used on delinquent participants. Four factors were extracted using the maximum likelihood method. No significant correlations were found between the personality scale scores and the PCL-R scores. Finally, cluster analysis of the reliable and valid psychopathy-related personality scales from the KSP (Impulsiveness, Monotony avoidance, Socialization, Verbal aggression, and Somatic anxiety) identified seven different clusters of delinquent participants.The uncertain validity of some personality traits (e.g., psychoticism or detachment), the poor reliability of many of the KSP scales (e.g., Guilt, Suspicion, and Inhibition of aggression) when used on this population, together with some minor limitations of the studies (e.g., sample size) are discussed.In conclusion, the high prevalence of psychopathy in the present sample of male delinquent participants may have important clinical treatment implications, particularly since some researchers have suggested that milieu therapy increases relapse rates into crime in adult psychopaths. Hopefully, appropriate assessment of personality traits and psychopathy (in addition to obvious routine assessments of mental disorders, such as substance abuse or disabilities such as dyslexia), supervision, and the implementation of effective correctional programs, may prevent young people with deviant personalities from aggravating their deviant style of living. Key words: Personality traits, psychopathy (PCL-R), juvenile delinquents, reliability, validity, assessment.
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| 24. |
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| 25. |
- Eriksson, Kaja, et al.
(författare)
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Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis
- 2019
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:5
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.
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| 26. |
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| 27. |
- Kvarnung, Malin, et al.
(författare)
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Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
- 2019
-
Ingår i: Frontiers in Genetics. - : Frontiers Media SA. - 1664-8021. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- The etiology of hereditary ataxia syndromes is heterogeneous, and the mechanisms underlying these disorders are often unknown. Here, we utilized exome sequencing in two siblings with progressive ataxia and muscular weakness and identified a novel homozygous splice mutation (c.3020-1G > A) in neurofascin (NFASC). In RNA extracted from fibroblasts, we showed that the mutation resulted in inframe skipping of exon 26, with a deprived expression of the full-length transcript that corresponds to NFASC isoform NF186. To further investigate the disease mechanisms, we reprogrammed fibroblasts from one affected sibling to induced pluripotent stem cells, directed them to neuroepithelial stem cells and finally differentiated to neurons. In early neurogenesis, differentiating cells with selective depletion of the NF186 isoform showed significantly reduced neurite outgrowth as well as fewer emerging neurites. Furthermore, whole-cell patch-clamp recordings of patient-derived neuronal cells revealed a lower threshold for openings, indicating altered Na+ channel kinetics, suggesting a lower threshold for openings as compared to neuronal cells without the NFASC mutation. Taken together, our results suggest that loss of the full-length NFASC isoform NF186 causes perturbed neurogenesis and impaired neuronal biophysical properties resulting in a novel early-onset autosomal recessive ataxia syndrome.
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| 28. |
- Landtblom, Anna Ravn, et al.
(författare)
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Childbirth rates in women with myeloproliferative neoplasms
- 2024
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Ingår i: Leukemia. - : SPRINGERNATURE. - 0887-6924 .- 1476-5551.
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Tidskriftsartikel (refereegranskat)abstract
- Myeloproliferative neoplasms (MPN) are associated with inferior pregnancy outcome, however, little is known about fertility and childbearing potential in women with MPN. In this study we aimed to describe reproductive patterns, as well as to quantify risk of miscarriage and stillbirth. Women aged 15-44 years with an MPN diagnosis 1973-2018, were identified in Swedish health care registers, and age-matched 1:4 to population controls. We identified 1141 women with MPN and 4564 controls. Women with MPN had a lower rate of childbirth (hazard ratio [HR] with 95% confidence interval was 0.78 (0.68-0.90)). Subgroup analysis showed that the rate was not significantly reduced in essential thrombocythemia, HR 1.02 (0.86-1.22) while the HR was 0.50 (0.33-0.76) in PV and 0.45 (0.28-0.74) in PMF. The risk of miscarriage was not significantly increased before MPN diagnosis, the HR during follow-up after diagnosis was 1.25 (0.89-1.76). Women with MPN were more likely to have had a previous stillbirth. Women with MPN had fewer children at diagnosis, and fewer children in total. In conclusion, the childbirth rate was lower among women with MPN than controls, but not among women with essential thrombocythemia.
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| 29. |
- Landtblom, Anna Ravn, et al.
(författare)
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Pregnancy and childbirth outcomes in women with myeloproliferative neoplasms-a nationwide population-based study of 342 pregnancies in Sweden
- 2022
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Ingår i: Leukemia. - : SPRINGER NATURE. - 0887-6924 .- 1476-5551. ; 36:10, s. 2461-2467
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Tidskriftsartikel (refereegranskat)abstract
- Pregnancy and childbirth in women with myeloproliferative neoplasms (MPN) are reported to be associated with maternal thrombosis, hemorrhage, and placental dysfunction. To assess the risks of adverse events in pregnancy in women with MPN, we performed a large population-based study using Swedish health care registers, and included all pregnancies that had reached gestational week 22 (prior to 2008, week 28) during the years 1973-2017 in women with MPN. Control pregnancies were matched 1:1 for age, calendar year, and parity. We identified 342 pregnancies in 229 women with MPN. Preterm birth was significantly increased in pregnancies in MPN, 14% compared to 4% of pregnancies in controls (p < 0.001). Correspondingly, low birth weight (<2500 g) was also significantly increased in MPN pregnancies (p = 0.042). Stillbirth was rare, with two events (0.6%) in MPN, none in controls. Maternal thrombotic complications occurred in three (1%) of the pregnancies in MPN patients, compared to none in controls. Pregnancy-related bleeding affected 14% of pregnancies in MPN and 9% in controls (p < 0.110). Cesarean section was significantly more common in pregnancies in MPN. Incidence was 12.2 per 100.000 pregnancies. In summary, preterm birth was an important complication in MPN pregnancies, while maternal complications were less common than previously reported.
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| 30. |
- Levin, Malin, 1973, et al.
(författare)
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Rip2 deficiency leads to increased atherosclerosis despite decreased inflammation.
- 2011
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Ingår i: Circulation research. - 1524-4571. ; 109:11, s. 1210-8
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Tidskriftsartikel (refereegranskat)abstract
- The innate immune system and in particular the pattern-recognition receptors Toll-like receptors have recently been linked to atherosclerosis. Consequently, inhibition of various signaling molecules downstream of the Toll-like receptors has been tested as a strategy to prevent progression of atherosclerosis. Receptor-interacting protein 2 (Rip2) is a serine/threonine kinase that is involved in multiple nuclear factor-κB (NFκB) activation pathways, including Toll-like receptors, and is therefore an interesting potential target for pharmaceutical intervention.
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| 31. |
- Lindberg, Anna, et al.
(författare)
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Barnens tid och framtid : En studie av den svenska asylbyråkratin efter 2015
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna studie är att analysera asylbyråkratins tidssyn, tidsanvändning och tidsstyrning samt peka på konsekvenserna av detta för skyddssökande familjer och rätten till asyl:Hur används tid och vilka perspektiv på tid tonar fram i asylprövningen på Migrationsverket, den myndighet som genomför svensk asylpolitik?Hur fördelas makten över tiden, mellan myndigheter och domstolar som fattar beslut i asylärenden, å ena sidan, och de skyddssökande familjerna vars framtid står på spel, å den andra?Vilka rättigheter följer med tiden?Vilken betydelse får tiden som barnen och deras föräldrar fått vänta för utfallet i ärendena?Hur samspelar tidsanvändningen och dess konsekvenser med barns rättigheter, nu när FN:s barnkonvention blivit svensk lag?
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| 32. |
- Lundberg, Anna, Professor, 1972-, et al.
(författare)
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En analys av tio barnfamiljers asylutredningar
- 2021
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Ingår i: Artikel 14. - Stockholm, Sweden : Flyktiggruppernas riksråd – FARR. - 1104-1846. ; :2, s. 15-19
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Anna Lindberg, Anna Lundberg och Mehek Muftee har läst och analyserat barnfamiljers asylakter. I denna artikel visar de med hjälp av olika exempel hur tid ges en central roll i Migrationsverkets utredningsarbete, som närmast låter sig beskrivas som en frenetisk jakt på kronologiska berättelser. Glapp i tidskronologin och tveksamma svar på frågor som rör tid resulterar i att den asylsökande misstänkliggörs och bedöms som icke-trovärdig, med konsekvens att hen får avslag på sin ansökan.
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| 33. |
- Lundberg, Anna, et al.
(författare)
-
Even if you are illiterate, I assume you still have a sense of time like everyone else." A qualitative analysis of temporal contradictions in Swedish asylum bureaucracy
- 2022
-
Ingår i: Sociologisk forskning. - : SOCIOLOGISK FORSKNING. - 0038-0342 .- 2002-066X. ; 59:3, s. 253-278
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Tidskriftsartikel (refereegranskat)abstract
- The article examines temporal governing in the Swedish asylum bureaucracy through a qualitative analysis of the case files of ten asylum-seeking families. The documents studied include more than 5,000 pages of asylum investigation protocols, decisions, court judgments, certificates, appeals, submissions, personal letters, memos, and other material. The study focuses on decisions made by the Swedish Migration Agency and the oral investigations documented by the agencys officers. Three inherent and overlapping contradictions related to the temporal governance of the Migration Agency are identified: 1) migration officials insist that asylum seekers provide a strict chronological narrative, whereas what they have lived through has been chaotic, 2) migration officials rush asylum seekers through the asylum process, but the applicant is then subjected to a stressful period of prolonged waiting, and 3) migration officials discount any speculation by asylum seekers when they explain why they are seeking protection, although speculation is unavoidable when conveying fears for the future. The contradictions affect the procedure for judging the asylum claim as well as the outcome of the assessment. The article also highlights consequences of time management paradoxes for asylum seekers and on the societal level in general
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| 34. |
- Lundberg, Anna, et al.
(författare)
-
"Även Om Du är Analfabet Så Antar Jag Att Du ändå Har En Tidsuppfattning Som Alla andra." : En Kvalitativ Analys Av Temporala motsättningar I Svensk asylbyråkrati
- 2022
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Ingår i: Sociologisk Forskning. - : Sociologisk Forskning, Swedish Sociological Association. - 2002-066X .- 0038-0342. ; 59:3, s. 253-278
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Tidskriftsartikel (refereegranskat)abstract
- Artikeln undersöker temporal styrning i den svenska asylbyråkratin genom en kvalitativ analys av tio familjers asylakter. Dessa består av över 5 000 sidors dokumentation: asylutredningsprotokoll, beslut, domar, intyg, överklaganden, inlagor, personliga brev, minnesnoteringar med mera. Studien fokuserar särskilt på Migrationsverkets beslut och de muntliga utredningar som myndighetens handläggare har protokollfört. Tre inneboende och överlappande motsättningar, som är relaterade till Migrationsverkets temporala styrning, identifieras i studien: 1) jakten på den kronologiska berättelsen i asylutredningen å ena sidan och ett kaosartat förflutet å den andra, 2) en frenetisk tidsanvändning som tar sig uttryck i en hetsig process samtidigt som den asylsökande är försatt i långvarig väntan, 3) en framåtsyftande redogörelse som inte får vara spekulativ samtidigt som spekulation, åtminstone delvis, är en ofrånkomlig del av att försöka göra sannolikt att man är i behov av skydd. Motsättningarna har anknytning till såväl proceduren för bedömning av asylansökan som utfallet i ärendet. Artikeln pekar även på några av konsekvenserna av tidsstyrningens paradoxer såväl för de asylsökande i Sverige som på samhällsnivå.
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| 35. |
- Magnusson, Cecilia, et al.
(författare)
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Migration and autism-spectrum disorder : population-based study
- 2012
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Ingår i: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 201:2, s. 109-115
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Tidskriftsartikel (refereegranskat)abstract
- Background: Migration has been implicated as a risk factor for autism, but evidence is limited and inconsistent. Aims: To investigate the relationship between parental migration status and risk of autism spectrum disorder, taking into consideration the importance of region of origin, timing of migration and possible discrepancies in associations between autism subtypes. Method: Record-linkage study within the total child population of Stockholm County between 2001 and 2007. Individuals with high- and low-functioning autism were defined as having autism spectrum disorder with and without comorbid intellectual disability, and ascertained via health and habilitation service registers. Results: In total, 4952 individuals with autism spectrum disorder were identified, comprising 2855 children with high-functioning autism and 2097 children with low-functioning autism. Children of migrant parents were at increased risk of low-functioning autism (odds ratio (OR) = 1.5, 95% CI 1.3-1.7); this risk was highest when parents migrated from regions with a low human development index, and peaked when migration occurred around pregnancy (OR=2.3, 95% CI 1.7-3.0). A decreased risk of high-functioning autism was observed in children of migrant parents, regardless of area of origin or timing of migration. Parental age, income or obstetric complications did not fully explain any of these associations. Conclusions: Environmental factors associated with migration may contribute to the development of autism presenting with comorbid intellectual disability, especially when acting in utero. High- and low-functioning autism may have partly different aetiologies, and should be studied separately.
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| 36. |
- Månsdotter, Anna, et al.
(författare)
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Parental share in public and domestic spheres: a population study on gender equality, death, and sickness.
- 2006
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Ingår i: Journal of epidemiology and community health. - : BMJ. - 0143-005X .- 1470-2738. ; 60:7, s. 616-20
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Tidskriftsartikel (refereegranskat)abstract
- STUDY OBJECTIVE: Examine the relation between aspects of gender equality and population health based on the premise that sex differences in health are mainly caused by the gender system. SETTING/ PARTICIPANTS: All Swedish couples (98 240 people) who had their first child together in 1978. DESIGN: The exposure of gender equality is shown by the parents' division of income and occupational position (public sphere), and parental leave and temporary child care (domestic sphere). People were classified by these indicators during 1978-1980 into different categories; those on an equal footing with their partner and those who were traditionally or untraditionally unequal. Health is measured by the outcomes of death during 1981-2001 and sickness absence during 1986-2000. Data are obtained by linking individual information from various national sources. The statistical method used is multiple logistic regressions with odds ratios as estimates of relative risks. MAIN RESULTS: From the public sphere is shown that traditionally unequal women have decreased health risks compared with equal women, while traditionally unequal men tend to have increased health risks compared with equal men. From the domestic sphere is indicated that both women and men run higher risks of death and sickness when being traditionally unequal compared with equal. CONCLUSIONS: Understanding the relation between gender equality and health, which was found to depend on sex, life sphere, and inequality type, seems to require a combination of the hypotheses of convergence, stress and expansion.
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| 37. |
- Proletov, Ian, et al.
(författare)
-
Primary and secondary glomerulonephritides 1.
- 2014
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 29 Suppl 3:May, s. 186-200
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Tidskriftsartikel (refereegranskat)
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| 38. |
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| 39. |
- Robba, Chiara, et al.
(författare)
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Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
- 2022
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535 .- 1466-609X. ; 26, s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods: Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO2 < 60 mmHg and severe hyperoxemia as PaO2 > 300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results: 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO2-AUC), for hyperoxemia was significantly associated with mortality (p = 0.003). Conclusions: In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration: clinicaltrials.gov NCT02908308, Registered September 20, 2016.
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| 40. |
- Robba, Chiara, et al.
(författare)
-
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients : a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
- 2022
-
Ingår i: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 48:8, s. 1024-1038
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Methods: Preplanned sub-analysis of the Target Temperature Management-2 trial. Clinical outcomes were mortality and functional status (assessed by the Modified Rankin Scale) 6 months after randomization. Results: A total of 1848 patients were included (mean age 64 [Standard Deviation, SD = 14] years). At 6 months, 950 (51%) patients were alive and 898 (49%) were dead. Median tidal volume (VT) was 7 (Interquartile range, IQR = 6.2–8.5) mL per Predicted Body Weight (PBW), positive end expiratory pressure (PEEP) was 7 (IQR = 5–9) cmH20, plateau pressure was 20 cmH20 (IQR = 17–23), driving pressure was 12 cmH20 (IQR = 10–15), mechanical power 16.2 J/min (IQR = 12.1–21.8), ventilatory ratio was 1.27 (IQR = 1.04–1.6), and respiratory rate was 17 breaths/minute (IQR = 14–20). Median partial pressure of oxygen was 87 mmHg (IQR = 75–105), and partial pressure of carbon dioxide was 40.5 mmHg (IQR = 36–45.7). Respiratory rate, driving pressure, and mechanical power were independently associated with 6-month mortality (omnibus p-values for their non-linear trajectories: p < 0.0001, p = 0.026, and p = 0.029, respectively). Respiratory rate and driving pressure were also independently associated with poor neurological outcome (odds ratio, OR = 1.035, 95% confidence interval, CI = 1.003–1.068, p = 0.030, and OR = 1.005, 95% CI = 1.001–1.036, p = 0.048). A composite formula calculated as [(4*driving pressure) + respiratory rate] was independently associated with mortality and poor neurological outcome. Conclusions: Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.
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| 41. |
- Thul, Peter J., et al.
(författare)
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A subcellular map of the human proteome
- 2017
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Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 356:6340
-
Tidskriftsartikel (refereegranskat)abstract
- Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we present a comprehensive image-based map of subcellular protein distribution, the Cell Atlas, built by integrating transcriptomics and antibody-based immunofluorescence microscopy with validation by mass spectrometry. Mapping the in situ localization of 12,003 human proteins at a single-cell level to 30 subcellular structures enabled the definition of the proteomes of 13 major organelles. Exploration of the proteomes revealed single-cell variations in abundance or spatial distribution and localization of about half of the proteins to multiple compartments. This subcellular map can be used to refine existing protein-protein interaction networks and provides an important resource to deconvolute the highly complex architecture of the human cell.
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| 42. |
- Vadeby, Anna, 1969-, et al.
(författare)
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Säker framkomlighet : sammanfattande slutrapport 2015
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Föreliggande rapport redovisar övergripande resultat av fyra olika åtgärder som implementerats inomTrafikverkets projekt ”Säker framkomlighet” vilket haft som syfte att förbättra framkomlighet ochtrafiksäkerhet på främst befintliga tvåfältsvägar med hastighetsgräns 90 km/tim. Åtgärderna somstuderats är: frästa mitträfflor på 2-fältsvägar, vägrensräffling på motorväg, smala mötesfria vägar(”gles 2+1-väg med räcke”) och riktningsseparerade vägar (2+1 med målad/räfflad mitt).Resultaten visar att för samtliga åtgärder har trafiksäkerhetseffekterna varit positiva med minskningarav de dödade och svårt skadade trafikanterna. Vad gäller spårdjupstillväxt visar resultaten att mitträfflinginte har en kanaliserande effekt på trafiken och därmed påverkas inte heller spårbildningen.För mötesfria vägar är den årliga spårdjupsutvecklingen cirka 25 procent högre för mötesfri väg än förmotsvarande vanlig väg för årsdygnstrafik (ÅDT) > 8 000 fordon/dygn. För lägre ÅDT är skillnaden 10–15 procent.För riktningsseparerade vägar visar resultaten endast på högre spårdjupstillväxt för ÅDT över 8 000fordon/dygn. En studie om effekter och konsekvenser av olika räffeltyper avseende buller visar att detinte finns kända argument för att inte använda sinusräffla, men ytterligare studier kring effekten förförare av tunga fordon rekommenderas. Studien avseende framkomlighetseffekter visar att andelentung trafik är en viktig faktor att beakta i utformningen av mötesfria vägar.
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| 43. |
- Aad, G., et al.
(författare)
-
- 2015
-
Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 92:3
-
Tidskriftsartikel (refereegranskat)
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| 44. |
- Aad, G., et al.
(författare)
-
- 2015
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :8
-
Tidskriftsartikel (refereegranskat)
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| 45. |
- Aad, G., et al.
(författare)
-
- 2015
-
Tidskriftsartikel (refereegranskat)
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| 46. |
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| 47. |
- Abbasian, Saeid, 1961-, et al.
(författare)
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Between Fire and Ice : Experiences of the Persian Fire Festival in a Nordic Setting
- 2020
-
Ingår i: Sustainability. - Schweiz : MDPI. - 2071-1050. ; 12:24
-
Tidskriftsartikel (refereegranskat)abstract
- This exploratory research seeks to gain insight into the visitors of Persian Fire Festival in Stockholm, their motivation, level of satisfaction and loyalty to the festival. The overall methodology is mixed methods consisting of participant observation and 280 completed online surveys including close-ended and open-ended questions. A Grounded theory analysis has been employed. The most important reason behind the participation has been to strive for the recognition of ethnic cultural identity; to keep the ancient culture alive; to maintain their ancestors’ legacy and transfer it to the next generation. Most of the visitors experienced positive feelings, showed satisfaction and loyalty, believed that the festival fulfilled their expectations and it should be celebrated officially every year. A minority showed dissatisfaction mostly due to the lack of accessibility to the event venue and might are not loyal to the festival. The first conclusion here is that these motivators are totally different than those mentioned by earlier research (e.g., escape, socialization, novelty, rest, prestige, excitement). Even though the desire to preserve the ancient culture and tradition is very strong, a lack of accessibility to the venue would constitute disloyalty and a barrier to re-attend in such a festival.
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| 48. |
- Abbasian, Saeid, 1961-, et al.
(författare)
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Festival Venue that makes sense : A study of Skansen arena in Stockholm
- 2021
-
Ingår i: Cogent Social Sciences. - : Cogent OA. - 2331-1886. ; 7:1, s. 1-15
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study is to investigate how the open-air museum ofSkansen in Stockholm as venue for celebration of Persian Fire Festival is assessed by thefestival’s visitors. The study is based on a delimited part of a larger online survey with280 completed questionnaires including both close-ended and open-ended questions,and a qualitative thematic analysis method has been used in this paper. The resultsshow a high level of appreciation of the Skansen venue that gives the visitors positiveemotions, meanings, place attachment, place identity and a sense of place. Contributingfactors have been the high status of the venue that has given the visitors pride anddignity; security and safety of the venue; size of the venue; and the natural beauty of thevenue. The most important disadvantage factor has been the lack of accessibilitycombined with lack of sufficient public transport. The results have implications for theSwedish society, for the policy makers in Stockholm city and for both the host and theorganiser of the festival and gives rise to new debates on immigrants’ socio-culturalintegration into Swedish society. This paper gives a contribution to existing literature onfestival venue and its impact on the visitor’s overall assessment of the festival.
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| 49. |
- Abbasian, Saeid, 1961-, et al.
(författare)
-
How the Iranian Fire Festival in Stockholm is perceived by the visitors?
- 2019
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Ingår i: 28th Nordic Symposium on Tourism and Hospitality Research 23rd to 25th October 2019. - Roskilde, Denmark : Roskilde University. ; , s. 45-
-
Konferensbidrag (refereegranskat)abstract
- Every year, a Tuesday in the middle of March and after 5:00 pm the Iranian Fire Festival (Eldfesten in Swedish, Chaharshanbe Suri in Persian) is celebrated outdoors in the center of Stockholm and ends before 10:00 pm. This event has its roots in ancient Persia, but now it is celebrated by several nations in the Middle East, Caucasus, and Central Asia. The Stockholm festival is arranged and financed by The Swedish National Theatre and several times earlier it has been opened by Swedish ministers. The event visitors are mostly of Middle Eastern background coming from Stockholm area. Since 2016 it can also be watched live through Swedish and foreign TV stations and through Social media. During the earlier years the event was held in Kungsträdgården (The Royal Garden) but this year it was arranged in the amusement park of Skansen. Ethnic cultural events in major urban areas create good images for cities and countries but also for immigrants and their neighborhoods in the city of issue (McClinchey, 2008; Loukaitou-Sideris and Soureli, 2012), and a sense of belonging among immigrants (Chacko, 2013). Many stakeholders are involved in such events (Getz et al 2007; Getz And Andersson, 2010) but perhaps the most important stakeholder is the visitors of the event. Therefore, it is of high relevance to study the visitors’ visit motivations, their perceived experience in terms of satisfaction level and their level of loyalty i.e. if they intend to visit the event next year (Savinovic et al, 2012). The aim of this research is to get insights on the visitors of the Fire Festival, their motives behind participation and how they perceive their participation afterwards. The main methods chosen in this research is participant observation and 257 completed surveys online until April 11th, 2019. Preliminary results The respondents are 63% men and 37% women, and they are mostly older than 40 (44% are older than 50). More than half of them have been living in Sweden less than 21 years of which 17% less than 5 years. 83% of the respondents call themselves Swedish-Iranians. More than 80% of the respondents have academic education (of which 7% with PhD education) and most of them are employed either by public or private sector. A considerable number of them are also either self- employed, students or retirees. They have come from different districts of Greater Stockholm while a minor part has come from municipalities outside the county. A pre-dominant majority of them have come there with friends and family members, and most of them have been participating in the festival for third times or more. Also, more than half of them have visited the Skansen park three or more times earlier. The main reasons why they celebrate the festival is to keep the old tradition and culture alive. The celebration creates feelings like happiness, pride, community, belonging, nostalgia, childhood, the Spring. Concerning the question what the place or arena means to you they either like Skansen or prefer other places in Greater Stockholm or do not care about the place but the festival and other issues such as security and safety. To the question “what do you think about celebrating the festival at Skansen” they give positive answers and to the question “are your expectations on the festival fulfilled” the majority are totally or partly agreed. They also believe that this event must be celebrated every year and give many improvement suggestions and additional critical comments such as more food trucks, better and cheaper food, more professional artists and happy songs and music.
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| 50. |
- Abelsson, Anna, et al.
(författare)
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Cardiopulmonary resuscitation quality during CPR practice versus during a simulated life-saving event
- 2018
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Ingår i: International Journal of Occupational Safety and Ergonomics. - : Taylor & Francis. - 1080-3548 .- 2376-9130. ; 24:4, s. 652-655
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction. As a part of the emergency medical services, the Swedish fire brigade can increase the survival rate in out-of-hospital cardiac arrests.Aim. To compare the quality of cardiopulmonary resuscitation (CPR) performed by firefighters at a routine CPR practice versus when involved in a simulated life-saving event.Methods. In this study, 80 firefighters divided into two groups performed CPR according to guidelines: one group indoors during a routine training session; the other group outdoors during a smoke diving exercise wearing personal protective clothing and self-contained breathing apparatus. Descriptive and inferential statistics were used to analyze the data.Results. The results showed a tendency for the outdoor group to perform CPR with better ventilation and compression quality, as compared to the indoor group. The ventilation of the manikin was not hampered by the firefighters wearing personal protective clothes and self-contained breathing apparatus, as the Swedish firefighters remove their facial mask and ventilate the patient with their mouth using a pocket mask.Conclusions. Overall, the results in both groups showed a high quality of CPR which can be related to the fire brigade training and education traditions. CPR training is regularly performed, which in turn helps to maintain CPR skills.
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