| 1. |
- Moberg, Christina, et al.
(författare)
-
De unga gör helt rätt när de stämmer staten
- 2022
-
Ingår i: Aftonbladet. - 1103-9000.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
|
|
| 2. |
|
|
| 3. |
- Bergengren, Jakob, et al.
(författare)
-
A recent Dreissena invasion in an old canal system in northern Europe
- 2015
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The Göta Canal was opened in 1832 and connects the Baltic and the Atlantic Sea via the large lakes Vänern and Vättern in south Sweden. Originally used for commercial transport, the canal is today one of the most popular tourist attractions in Sweden with canal cruises, pleasure boating and canoeing. Inventories in 2013 showed that Dreissena mussels recently have invaded lakes, streams and canals in the Motala River drainage basin, i.e. the eastern part of the Göta Canal. According to interviews with local people the mussels may have been there since 2012. During the late summer in 2013 and in 2014 we monitored mussels by scuba diving and we sampled planktonic larval populations in locks and the canal. Dreissena has not dispersed to the western part of the canal system, i.e. west of lake Vättern, where most lakes are oligotrophic with low Ca- andMg-levels. In the eastern part, where several lakes are eutrophic and Ca- and Mg-levels higher, populations have increased very fast. The inventories showed local densities of 10 000 adults m-2 in some eutrophic lakes and larval densities of up to 70 individuals L-1 in the canal water. In Europe, the large range expansion of Dreissena occurred during the late 19th and early 20th century. Why have they dispersed so late into the Göta Canal, i.e. some 170 years after the canal was constructed and some 80 years after they had dispersed to other lakes in Swedennorth of Göta Canal? We can not dismiss dispersal as a a limiting factor but given the historically sustained boat traffic in the region it seems likely that ecological factors may have been important. Freshwaters in Scandinavia are usually low in Ca and Mg and many lakes are characterized by oligotrophic conditions poor in food for filter-feeding Dreissena. In the Göta Canal, changes in biological factors affecting relationships between Dreissena and the regional biota needs to be studied, however. Although we can not explain the delayed invasion we conclude that Dreissena is now established in one of the largest canal system in northern Europe.
|
|
| 4. |
- Bergengren, Jakob, et al.
(författare)
-
Nationell musselövervakning : Förslag till val av nationella musselvatten
- 2009
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Ett grundläggande förslag ; Miljöövervakningsstrategi för stormusslor ”Utveckling av nationell miljöövervakning för sötvattenslevande stormusslor 2008” har tagits fram under 2008-2009 av Stefan Lundberg, Naturhistoriska riksmuseet, i samarbete med Jakob Bergengren, Länsstyrelsen i Jönköping enligt uppdrag 216 0740. Den 2 oktober 2008 anordnades ett referensgruppsmöte på Naturhistoriska riksmuseet. Deltagare var Jakob Bergengren, Lst-F, Stefan Lundberg och Thomas Lyrholm (del av mötet), NRM, Marie Eriksson, Lst-M, Cecilia Journath-Pettersson, Lst-T, Erik Årnfelt, Lst- E, Oskar Norrgrann, Håkan Söderberg och Frans Olofsson, Lst-Y, samt Håkan Marklund,NV. Vid detta möte beslutades att ta fram ett förslag till val av nationella musselvatten för övervakning utifrån ett upplägg med både trendstationer (undersökning enligt den kompletta undersökningstypen) samt screening (undersökning enligt den s.k. förenklade statusbedömningen). Den 15 januari 2009 träffades referensgruppen igen. Deltagare vid mötet var Jakob Bergengren, Lst-F, Stefan Lundberg, NRM, Marie Eriksson, Lst-M, Cecilia Journath- Pettersson, Lst-T, Helena Herngren, Lst-D, Håkan Söderberg, och Frans Olofsson, Lst-Y,Lena Tranvik, ADb, samt Håkan Marklund och Ulrika Stensdotter-Blomberg, NV. Föreliggande förslag har tagits fram efter synpunkter av ovanstående referensgrupp. Nedan, under ’Förslag – Nationella vatten’, redovisas förslag enligt Trend+Screening. Även det tidigare förslaget (enligt avtal 216 0740), bakgrund till detta, samt urvalskriterier, redovisas.
|
|
| 5. |
- Bergengren, Jakob, et al.
(författare)
-
Stormusselprojektet 2001 : UTVECKLING AV METODIK OCH UNDERSÖKNINGSTYP - BESKRIVNING AV HABITATVAL-FÖREKOMST I FEM LÄN I SÖDRA SVERIGE
- 2001
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- SammanfattningMål med stormusselprojektetHuvudmålet med detta projekt är att ta fram förslagpå lämpliga undersökningstyper för övervakningav målarmusslor och dammusslor. Ett delmålär att utröna i vilka sötvattensmiljöer de tre arternaav dammusslor respektive de tre arterna avmålarmusslor förekommer. Arbetet har också gettmycket värdefull kunskap om stormusslornas förekomstoch status i de undersökta länen.Undersökta arterUndersökningarna har koncentrerats till lokalermed de nationellt rödlistade arterna tjockskaligmålarmussla,Unio crassus [starkt hotad (EN),även upptagen i Natura 2000] samt flat dammmusslaPseudanodonta complanata[missgynnad(NT)]. Flodpärlmusslan [sårbar (VU), samt Natura2000 art] är idag den mest kända av de totaltåtta i Sverige förekommande större arterna avsötvattensmusslor. Flodpärlmusslan är nationelltsett väl undersökt och ägnades därför mindre intressei detta arbete. De övriga sju omfattar:Unio(målarmusslor, tre arter),Anodonta/Pseudanodonta(dammusslor, tre arter) ochDreissena polymorpha(vandrarmussla). De arter som undersöktslistas i Tabell 1 nedan.Tabell 1. Undersökta arter i stormusselprojektet.Vetenskapligt namn Svenskt namnMargaritifera margaritiferaFlodpärlmusslaUnio pictorumAllmän målarmusslaUnio tumidusSpetsig målarmusslaUnio crassusTjockskalig målarmusslaAnodonta anatinaAllmän dammusslaAnodonta cygneaStor dammusslaPseudanodonta complanataFlat dammusslaUndersökningarnas omfattningUndersökningarna har genomförts i fem län (Södermanland,Östergötland, Kalmar, Jönköpingoch Skåne). Totalt har 56 lokaler i vattendragsamt 32 lokaler i sjöar undersökts. Fältarbetet harutförts av Jakob Bergengren med assistans av personalfrån länsstyrelserna i de berörda länen. Planeringenav arbetet och analysen av materialet harutförts i samarbete med Stefan Lundberg frånNaturhistoriska riksmuseet i Stockholm och Tedvon Proschwitz vid Naturhistoriska museet i Göteborg.Utveckling av metodik ochframtagande av nyundersökningstypVid metodutvecklingen har undersökningar av lokalermed tjockskalig målarmussla (U. crassus)och flat dammussla (P. complanata) prioriterats,men även lokaler med de andra musselarterna harundersökts. Nedan beskrivs föreslagna undersökningsmetoderi sjöar respektive vattendrag.Metodik i sjöarAtt undersöka ett musselbestånd i en sjö är svårareän att arbeta på en avgränsad sträcka i ett vattendrag.Att skaffa sig en total uppfattning om ettmusselbestånd, inte sällan med förekomst av fleraarter, i en sjö är arbetsmässigt tidskrävande. Denofta skiftande karaktären när det gäller bottensubstrat,bottenvegetation och djupförhållanden gördet omöjligt att undersöka en hel sjö.Följande metoder föreslås att användas i sjöar:?Undersökning med vattenkikare i sjöarsin- och utlopp.Dessa är lätta att avgränsaoch undersöks och övervakas i ett första skededå de ofta hyser flest arter. Kvalitativ ochkvantitativ övervakning.?Linjetaxering används om förhållandenamedger (siktdjup, bottenförhållanden mm).Denna metod medger övervakning av en avgränsad,subjektivt vald, sträcka. Kvalitativoch kvantitativ övervakning. Särskilda ansträngningarskall alltid göras för att finnajuSt o r m u s s e l p r o j e k t e t 2 0 0 1 , D e l 112venila musslor, då dessa indikerar att populationenreproducerar sig.?Luttnerräfsa används om förhållandena ärså svåra att ingen av ovanstående metoderfungerar. Inventering med Luttnerräfsa gerenbart en kvalitativ uppfattning om musselfaunan.Metodik i vattendragAtt undersöka ett musselbestånd i ett vattendragär ofta, men inte alltid, lättare än undersökningar ien sjö. Följande metoder föreslås att användas vidundersökningar av stormusslor i vattendrag:?Undersökning med vattenkikare. Om vattendragetär relativt grunt, vadbart och siktförhållandenagoda, är det ofta möjligt att användaen något modifierad variant av den befintligametodiken för undersökning av flodpärlmussla.De förekommande arterna räknasseparat för att en populationsuppskattning förrespektive art ska kunna göras. Vid användandeav flodpärlmusselmetodiken skall 15lokaler avgränsas och noggrant undersökas.Särskilda ansträngningar skall alltid göras föratt finna juvenila musslor, då dessa indikeraratt populationen reproducerar sig.?Fridykning. Om vattendraget innehållersträckor som är svåra att undersöka (stortvattendjup, dåliga siktförhållanden, högastrandbrinkar etc.), är undersökning medvattenkikare inte möjligt. I dessa fall rekommenderasfridykning. Denna metod är kvalitativoch semikvantitativ. En fördel med fridykningär att sökandet efter juvenila musslorblir effektivare.?Luttnerräfsa. Används då förhållandena ärsådana att ingen av de båda ovanståendemetoderna kan användas (obefintligt siktdjup,låg vattentemperatur). Metoden ger enbart enkvalitativ bild av musselfaunan.Stormusslornas habitatvalI Stormusselprojektet har musslornas val av habitatundersökts genom att typ av bottensubstratsamt vattendjup noterats för varje lokal under inventeringen.Undersökningarna har utförts på enavgränsad sträcka (en lokal) i ett vattendrag ellerinom ett bestämt område (en lokal) i en sjö.Bottensubstrat – VattendragStormusslornas val av bottensubstrat i vattendragenkan sammanfattas i följande punkter:?Mjäla/ler dominerar som det mest prefereradesubstratet för samtliga arter.?De subdominerande substraten består till stordel av grövre material huvudsakligen grus.?Det substrat som uppvisar högst frekvens pålokalerna är grus/fin sten/grov sten. Detta ärlogiskt då dessa fraktioner är de mest förekommandei vattendrag överlag.Bottensubstrat – SjöarArternas val av bottensubstrat i sjöar kan sammanfattasi följande punkter?Mjäla/ler dominerar, liksom i vattendragen,som det mest prefererade substratet. Dettagäller samtliga arter utom den allmännadammusslan (A. anatina). Denna tycks föredrasand som bottensubstrat.?De subdominerande substraten består tillstörsta delen av fraktioner med sand och finsten.?Det bottensubstrat som uppvisar högst frekvenspå lokalerna är findetritus. Detta är logiskteftersom findetritus är det dominerandesubstratet i sjöar med kraftig sedimentation.Djupintervall – VattendragArternas förekomst i olika djupintervall i undersöktavattendrag kan sammanfatts i följandepunkter:?Medeldjupet som arterna återfanns på varieradei liten utsträckning, både mellan de olikaarterna samt mellan de olika vattendragen.?Den tjockskaliga målarmusslan (U. crassus)finns på de grundare (strömmande) partierna ide undersökta vattendragen. Medeldjupet förarten var 0,55 m.?Den stora dammusslan (A. cygnea) finns oftarepå djupare (lugnflytande) partier och förekommerpå ett medeldjup av 0,75 m.?Övriga arter har förekomster i djupintervallet0,55 - 0,75 m.Anmärkning: i vattendragen undersöktes stormusslornasutbredning ner till ca 3 meters djup.Djupintervall – SjöarArternas förekomst i olika djupintervall i undersöktasjöar kan sammanfatts i följande punkter:?Medeldjupet som arterna återfanns på varieradei större utsträckning i sjöarna än i vattendragen.?De två arter av målarmusslor (U. pictorumochU. tumidus) som förekom i sjöarna fannsS t o r m u s s e l p r o j e k t e t 2 0 0 1 , D e l 113på större djup än de tre undersökta dammusselarterna.?Den allmänna målarmusslan (U. pictorum)förekom på störst djup (medeldjup 1,5 m)medan den stora dammusslan (A. cygnea)fanns på ett medeldjup som enbart var 0,55m. Här bör dock beaktas att endast sex respektiveåtta lokaler ligger till grund för dettapåstående.Anmärkning: i sjöarna undersöktes stormusslornasutbredning ner till ca 4 meters djup.Stormusslornas utbredning ochförekomst skiftarStormusselfynd – totalt settDen allmänna dammusslan (A. anatina) visade sigvara den vanligaste arten och hittades på flest lokaler(Tabell 2). Flodpärlmusslan (M. margaritifera),som ej var prioriterad i detta projekt då dentidigare varit föremål för många undersökningar,hittades endast på fem lokaler (Tabell 2).Tabell 2. Stormussellokaler i respektive län (D = Södermanland, E = Östergötland, , H = Kalmar, F = Jönköping, M = Skåne).Fynd LänVetenskapligt namn Svenskt namn Samtliga fyndlokaler D E H F MM. margaritiferaFlodpärlmussla 5 0 1 0 1 3U. pictorumAllmän målarmussla 13 2 3 2 0 6U. tumidusSpetsig målarmussla 40 6 12 9 4 9U. crassusTjockskalig målarmussla 24 6 3 5 1 9A. anatinaAllmän dammussla 52 3 11 9 16 13A. cygneaStor dammussla 21 2 5 4 6 4P. complanataFlat dammussla 10 4 3 1 0 2Totalt antal undersökta lokaler:88 9 15 16 25 23Sjö eller vattendrag?Det är svårt att jämföra antalet fynd från de olikalänen med varandra då antalet undersökta sjöaroch vattendrag varierar både inom och mellan länen.Vid undersökningen kunde de olika arternasförekomst i sjöarna och vattendragen visas generellt.Utifrån hela inventeringsunderlaget kan följandeslutsatser dras (Tabell 3):?Tjockskalig målarmussla (U. crassus) (ochflodpärlmussla) påträffades enbart i vattendrag.?Stor dammussla (A. cygnea) förekommerfrämst i sjöar. Arten påträffades enbart i 8vattendrag.?Flat dammussla (P. complanata) förekommerfrämst i vattendrag. Den påträffades endast i2 sjöar.?Spetsig målarmussla (U. tumidus), allmänmålarmussla (U. pictorum) och allmän dammussla(A. anatina) förekommer lika ofta isjöar som i vattendrag.Tabell 3. Förekomst av arterna i sjöar och vattendrag i hela materialet i absolut och relativ (%) frekvens.Sjö eller Vattendrag (antal) Antal %Vetenskapligt namn Svenskt namn Lokaler Sjöar Vattendrag Sjöar VattendragM. margaritiferaFlodpärlmussla 5 0 5 0 100U. pictorumAllmän målarmussla 13 6 7 46 54U. tumidusSpetsig målarmussla 40 21 19 52 48U. crassusTjockskalig målarmussla 24 0 24 0 100A. anatinaAllmän dammussla 52 24
|
|
| 6. |
- Björklund, Johanna, 1961-, et al.
(författare)
-
Ecosystem-based agriculture combining production and conservation : a viable way to feed the world in the long term?
- 2012
-
Ingår i: Journal of Sustainable Agriculture. - : Taylor & Francis. - 1044-0046 .- 1540-7578. ; 36:7, s. 824-855
-
Tidskriftsartikel (refereegranskat)abstract
- This study analyzed examples of sustainable ecosystem-based agriculture where management methods supported livelihoods of smallholders while at the same time local ecosystem services were enhanced in Ethiopia, Brazil, and the Philippines. Participation by farmers and collective actions were found to be a crucial driving force, as local specific knowledge and “learning by doing” were main components of the development. Social cohesion, particularly through associations and cooperatives, and improved marketing opportunities were also important drivers. Furthermore, recognition by authorities at all levels was perceived as crucial. Effects of climate change, insecure property rights, and political instability were potential threats. The possibilities of such systems to be scaled up beyond self-sufficiency raised further questions.
|
|
| 7. |
|
|
| 8. |
- Bodin, Örjan, et al.
(författare)
-
The value of small size: loss of forest patches and ecological thresholds in southern Madagascar
- 2006
-
Ingår i: Ecological Applications. - : the Ecological Society of America. - 1051-0761 .- 1939-5582. ; 16:2, s. 440-451
-
Tidskriftsartikel (refereegranskat)abstract
- Many services generated by forest ecosystems provide essential support for human well-being. However, the vulnerability of these services to environmental change such as forest fragmentation are still poorly understood. We present spatial modeling of the generation of ecosystem services in a human-dominated landscape where forest habitat patches, protected by local taboos, are located in a matrix of cultivated land in southern Madagascar. Two ecosystem services dependent on the forest habitats were addressed: (1) crop pollination services by wild and semidomesticated bees (Apoidea), essential for local crop production of, for example, beans, and (2) seed dispersal services based on the presence of ring-tailed lemurs (Lemur catta). We studied the vulnerability of these ecosystem services to a plausible scenario of successive destruction of the smallest habitat patches. Our results indicate that, in spite of the fragmented nature of the landscape, the fraction of the landscape presently covered by both crop pollination and seed dispersal services is surprisingly high. It seems that the taboo system, though indirectly and unintentionally, contributes to upholding the generation of these services by protecting the forest patches. Both services are, however, predicted to be very vulnerable to the successive removal of small patches. For crop pollination, the rate of decrease in cover was significant even when only the smallest habitat patches were removed. The capacity for seed dispersal across the landscape displayed several thresholds with habitat patch removal. Our results suggest that, in order to maintain capacity for seed dispersal across the landscape and crop pollination cover in southern Androy, the geographical location of the remaining forest patches is more crucial than their size. We argue that in heavily fragmented production landscapes, small forest patches should increasingly be viewed as essential for maintaining ecosystem services, such as agricultural production, and also should be considered in the ongoing process of tripling the area of protected habitats in Madagascar.
|
|
| 9. |
- Brokken, Leon, et al.
(författare)
-
Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer.
- 2013
-
Ingår i: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 4:Feb.,14
-
Tidskriftsartikel (refereegranskat)abstract
- In the Western world, testicular germ cell cancer (TGCC) is the most common malignancy of young men. The malignant transformation of germ cells is thought to be caused by developmental and hormonal disturbances, probably related to environmental and lifestyle factors because of rapidly increasing incidence of TGCC in some countries. Additionally, there is a strong genetic component that affects susceptibility. However, genetic polymorphisms that have been identified so far only partially explain the risk of TGCC. Many of the persistent environmental pollutants act through the aryl hydrocarbon receptor (AHR). AHR signaling pathway is known to interfere with reproductive hormone signaling, which is supposed to play a role in the pathogenesis and invasive progression of TGCC. The aim of the present study was to identify whether AHR-related polymorphisms were associated with risk as well as histological and clinical features of TGCC in 367 patients and 537 controls. Haplotype-tagging single-nucleotide polymorphisms (SNPs) were genotyped in genes encoding AHR and AHR repressor (AHRR). Binary logistic regression was used to calculate the risk of TGCC, non-seminoma versus seminoma, and metastasis versus localized disease. Four SNPs in AHRR demonstrated a significant allele association with risk to develop metastases (rs2466287: OR = 0.43, 95% CI 0.21-0.90; rs2672725: OR = 0.49, 95% CI: 0.25-0.94; rs6879758: OR = 0.27, 95% CI: 0.08-0.92; rs6896163: OR = 0.34, 95% CI: 0.12-0.98). This finding supports the hypothesis that compounds acting through AHR may play a role in the invasive progression of TGCC, either directly or through modification of reproductive hormone action.
|
|
| 10. |
- Börjesson, Karl, 1982, et al.
(författare)
-
Soft-Surface DNA Nanotechnology: DNA Constructs Anchored and Aligned to Lipid Membrane
- 2011
-
Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 50:36, s. 8312-8315
-
Tidskriftsartikel (refereegranskat)abstract
- No strings attached: At least three attachment points are needed to align a two-dimensional DNA nanoconstruct to a soft lipid membrane surface with a porphyrin nucleoside as membrane anchor (see picture). The resulting freely diffusing DNA constructs can be reversibly assembled on the surface thus enabling the possibility of a self-repairing system. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
|
|
| 11. |
- Chang, Yun Chien, et al.
(författare)
-
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
- 2024
-
Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 43:6
-
Tidskriftsartikel (refereegranskat)abstract
- Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action (MoA) and substantial toxicity are not well understood. To shed more light on how KDACis elicit cellular responses, we systematically measured dose-dependent changes in acetylation, phosphorylation, and protein expression in response to 21 clinical and pre-clinical KDACis. The resulting 862,000 dose-response curves revealed, for instance, limited cellular specificity of histone deacetylase (HDAC) 1, 2, 3, and 6 inhibitors; strong cross-talk between acetylation and phosphorylation pathways; localization of most drug-responsive acetylation sites to intrinsically disordered regions (IDRs); an underappreciated role of acetylation in protein structure; and a shift in EP300 protein abundance between the cytoplasm and the nucleus. This comprehensive dataset serves as a resource for the investigation of the molecular mechanisms underlying KDACi action in cells and can be interactively explored online in ProteomicsDB.
|
|
| 12. |
- Colding, Johan, et al.
(författare)
-
Incorporating Green-Area User Groups in Urban Ecosystem Management
- 2006
-
Ingår i: Ambio. - 0044-7447 .- 1654-7209. ; 35:5, s. 237-244
-
Tidskriftsartikel (refereegranskat)abstract
- We analyze the role of urban green areas managed by local user groups in their potential for supporting biodiversity and ecosystem services in growing city-regions, with focus on allotment areas, domestic gardens, and golf courses. Using Stockholm, Sweden, as an example city-region, we compile GIS data of its spatial characteristics and relate these data to GIS data for protected areas and "green wedges" prioritized in biodiversity conservation. Results reveal that the three land uses cover 18% of the studied land area of metropolitan Stockholm, which corresponds to more than twice the land set aside as protected areas. We review the literature to identify ecosystem functions and services provided by the three green areas and discuss their potential in urban ecosystem management. We conclude that the incorporation of locally managed lands, and their stewards and institutions, into comanagement designs holds potential for improving conditions for urban biodiversity, reducing transaction costs in ecosystem management, and realizing local Agenda 21.
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
- Costa, Adriana, et al.
(författare)
-
PLS3 Mutations in X-Linked Osteoporosis : Clinical and Genetic Features in Five New Families
- 2023
-
Ingår i: Calcified Tissue International. - : Springer. - 0171-967X .- 1432-0827. ; 114, s. 157-170
-
Tidskriftsartikel (refereegranskat)abstract
- Childhood-onset osteoporosis is a rare but clinically significant condition. Studies have shown pathogenic variants in more than 20 different genes as causative for childhood-onset primary osteoporosis. The X-chromosomal PLS3, encoding Plastin-3, is one of the more recently identified genes. In this study, we describe five new families from four different European countries with PLS3-related skeletal fragility. The index cases were all hemizygous males presenting with long bone and vertebral body compression fractures. All patients had low lumbar spine bone mineral density (BMD). The age at the first clinical fracture ranged from 1.5 to 13 years old. Three of the identified PLS3 variants were stop-gain variants and two were deletions involving either a part or all exons of the gene. In four families the variant was inherited from the mother. All heterozygous women reported here had normal BMD and no bone fractures. Four patients received bisphosphonate treatment with good results, showing a lumbar spine BMD increment and vertebral body reshaping after 10 months to 2 years of treatment. Our findings expand the genetic spectrum of PLS3-related osteoporosis. Our report also shows that early treatment with bisphosphonates may influence the disease course and reduce the progression of osteoporosis, highlighting the importance of early diagnosis for prompt intervention and appropriate genetic counseling.
|
|
| 16. |
- Dandotiya, Rajiv, et al.
(författare)
-
A systematic evaluation of devices for measuring abrasive wear of mill liners
- 2009
-
Ingår i: 22nd International Congress on Condition Monitoring and Diagnostic Engineering Management. - Eibar : Fundaci n Tekniker. - 9788493206468 ; , s. 419-427
-
Konferensbidrag (refereegranskat)abstract
- Inspection of the liner wear in the mill of an ore dressing plant is one of the critical parameters in the context of mill downtime and production performance. The total downtime cost during measurement can be reduced by a significant fraction by using appropriate measurement devices. Due to the different quality dimensions of a measuring device, e.g. the cost, accuracy, reliability and accessibility, it is necessary to select an appropriate device based on the specific needs of the industry. Customer satisfaction is perhaps the most important performance measure for the service quality of the device, and therefore this paper provides an approach to define the customer satisfaction with reference to the mentioned quality dimensions. The main aim of this paper is to determine a unified measure or quality index for the service quality of the measurement device across all the dimensions. Each quality index will then correspond to the total predicted usability of the particular measurement method based on the industry needs. Furthermore, this study also discusses the advantages and disadvantages of existing measurement methods and proposes an indirect measurement method to reduce the downtime during inspection.
|
|
| 17. |
- Dengjel, Joern, et al.
(författare)
-
Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens
- 2012
-
Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 11:3
-
Tidskriftsartikel (refereegranskat)abstract
- Autophagy is one of the major intracellular catabolic pathways, but little is known about the composition of autophagosomes. To study the associated proteins, we isolated autophagosomes from human breast cancer cells using two different biochemical methods and three stimulus types: amino acid deprivation or rapamycin or concanamycin A treatment. The autophagosome- associated proteins were dependent on stimulus, but a core set of proteins was stimulus- independent. Remarkably, proteasomal proteins were abundant among the stimulus- independent common autophagosome- associated proteins, and the activation of autophagy significantly decreased the cellular proteasome level and activity supporting interplay between the two degradation pathways. A screen of yeast strains defective in the orthologs of the human genes encoding for a common set of autophagosome- associated proteins revealed several regulators of autophagy, including subunits of the retromer complex. The combined spatiotemporal proteomic and genetic data sets presented here provide a basis for further characterization of autophagosome biogenesis and cargo selection.
|
|
| 18. |
- Elmqvist, Thomas, et al.
(författare)
-
The Dynamics of Social-Ecological Systems in Urban Landscapes
- 2004
-
Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. ; 1023, s. 308-322
-
Tidskriftsartikel (refereegranskat)abstract
- This study addresses social-ecological dynamics in the greater metropolitan area of Stockholm County, Sweden, with special focus on the National Urban Park (NUP). It is part of the Millennium Ecosystem Assessment (MA) and has the following specific objectives: (1) to provide scientific information on biodiversity patterns, ecosystem dynamics, and ecosystem services generated; (2) to map interplay between actors and institutions involved in management of ecosystem services; and (3) to identify strategies for strengthening social-ecological resilience. The green areas in Stockholm County deliver numerous ecosystem services, for example, air filtration, regulation of microclimate, noise reduction, surface water drainage, recreational and cultural values, nutrient retention, and pollination and seed dispersal. Recreation is among the most important services and NUP, for example, has more than 15 million visitors per year. More than 65 organizations representing 175,000 members are involved in management of ecosystem services. However, because of population increase and urban growth during the last three decades, the region displays a quite dramatic loss of green areas and biodiversity. An important future focus is how management may reduce increasing isolation of urban green areas and enhance connectivity. Comanagement should be considered where locally managed green space may function as buffer zones and for management of weak links that connect larger green areas; for example, there are three such areas around NUP identified. Preliminary results indicate that areas of informal management represent centers on which to base adaptive comanagement, with the potential to strengthen biodiversity management and resilience in the landscape.
|
|
| 19. |
- Enlund, Mats, et al.
(författare)
-
Survival after primary breast cancer surgery following propofol or sevoflurane general anesthesia-A retrospective, multicenter, database analysis of 6305 Swedish patients
- 2020
-
Ingår i: Acta Anaesthesiologica Scandinavica. - : John Wiley & Sons. - 0001-5172 .- 1399-6576. ; 64:8, s. 1048-1054
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Retrospective studies indicate that the choice of anesthetic can affect long-term cancer survival. Propofol seems to have an advantage over sevoflurane. However, this is questioned for breast cancer. We gathered a large cohort of breast cancer surgery patients from seven Swedish hospitals and hypothesized that general anesthesia with propofol would be superior to sevoflurane anesthesia regarding long-term breast cancer survival.Methods: We identified all patients who were anaesthetized for breast cancer surgery between 2006 and 2012. The patients were matched to the Swedish Breast Cancer Quality Register, to retrieve tumor characteristics, prognostic factors, and adjuvant treatment as well as date of death. Overall survival between patients undergoing sevoflurane and propofol anesthesia was analyzed with different statistical approaches: (a) multiple Cox regression models adjusted for demographic, oncological, and multiple control variables, (b) propensity score matching on the same variables, but also including the participating centers as a cofactor in a separate analysis.Results: The database analysis identified 6305 patients. The 5-year survival rates were 91.0% and 81.8% for the propofol and sevoflurane group, respectively, in the final model (P = .126). Depending on the statistical adjustment method used, different results were obtained, from a non-significant to a "proposed" and even a "determined" difference in survival that favored propofol, with a maximum of 9.2 percentage points higher survival rate at 5 years (hazard ratio 1.46, 95% CI 1.10-1.95).Conclusions: It seems that propofol may have a survival advantage compared with sevoflurane among breast cancer patients, but the inherent weaknesses of retrospective analyses were made apparent.
|
|
| 20. |
- Leandersson Bogefors, Karolina, et al.
(författare)
-
Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment
- 2017
-
Ingår i: Asian Journal of Andrology. - 1008-682X .- 1745-7262. ; 19:5, s. 538-542
-
Tidskriftsartikel (refereegranskat)abstract
- Spermatogenesis is an androgen-regulated process that depends on the action of androgen receptor (AR). Sperm production may be affected in men treated for testicular cancer (TC), and it is important to identify the factors influencing the timing of spermatogenesis recovery following cancer treatment. It is known that the CAG and GGN repeat numbers affect the activity of the AR; therefore, the aim of this study is to investigate if the CAG and GGN polymorphisms in the AR gene predict recovery of sperm production after TC treatment. TC patients (n = 130) delivered ejaculates at the following time points: postorchiectomy and at 6, 12, 24, 36, and 60 months posttherapy (T0, T6, T12, T24, T36, and T60). The CAG lengths were categorized into three groups, <22 CAG, 22-23 CAG, and >23 CAG, and the GGN tracts were also categorized into three groups, <23 GGN, 23 GGN, and >23 GGN. At T12, men with 22-23 CAG presented with a statistically significantly (P = 0.045) lower sperm concentration than those with other CAG numbers (8.4 × 10 6 ml-1 vs 16 × 10 6 ml-1 ; 95% CI: 1.01-2.65). This association was robust to omitting adjustment for treatment type and sperm concentration at T0 (P = 0.021; 3.7 × 10 6 ml-1 vs 10 × 10 6 ml-1 ; 95% CI: 1.13-4.90). The same trends were observed for total sperm number. The least active AR variant seems to be associated with a more rapid recovery of spermatogenesis. This finding adds to our understanding of the biology of postcancer therapy recovery of fertility in males and has clinical implications.
|
|
| 21. |
|
|
| 22. |
- Lundberg, Jakob, et al.
(författare)
-
Linkages beyond borders : targeting spatial processes in fragmented urban landscapes
- 2008
-
Ingår i: Landscape Ecology. - : Springer Science and Business Media LLC. - 0921-2973 .- 1572-9761. ; 23:6, s. 717-726
-
Tidskriftsartikel (refereegranskat)abstract
- Management of ecosystems often focuses on specific species chosen for their habitat demand, public appeal, or levels of threat. We propose a complementary framework for choosing focal species, the mobile link concept, which allows managers to focus on spatial processes and deal with multi-scale ecological dynamics. Spatial processes are important for three reasons: maintenance, re-organization, and restoration of ecological values. We illustrate the framework with a case study of the Eurasian Jay, a mobile link species of importance for the oak forest regeneration in the Stockholm National Urban Park, Sweden, and its surroundings. The case study concludes with a conceptual model for how the framework can be applied in management. The model is based on a review of published data complemented with a seed predation experiment and mapping of Jay territories to reduce the risk of applying non-urban site-specific information in an urban setting. Our case study shows that the mobile link approach has several advantages: (1) Reducing the vulnerability of ecological functions to disturbances and fluctuations in resources allocated to management, (2) Reducing management costs by maintaining natural processes, and (3) Maintaining gene flow and genetic diversity at a landscape level. We argue that management that includes mobile link organisms is an important step towards the prevention of ecosystem degradation and biodiversity loss in increasingly fragmented landscapes. Identifying and managing mobile links is a way to align management with the ecologically relevant scales in any landscape.
|
|
| 23. |
|
|
| 24. |
- Lundberg, Jakob, 1967-
(författare)
-
Rethinking Urban Nature : Maintaining Capacity for Ecosystem Service Generation in a Human Dominated World
- 2006
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Human action has transformed the major part of the Earth’s ecosystems. A growing human population puts further pressure on dynamic landscapes and resources. Crucially, for the first time in history, most people live in cities and environmental change has become truly global. Developed as part of the sub-global assessments of The Millennium Ecosystem Assessment, this thesis examines anthropogenic effects on our life-support systems, and their altered capacity to generate goods and services of socio-economic value. It incorporates humans into the analysis of ecosystem dynamics and explores new ways to restore, create, and enhance ecosystem services in urban and other fragmented landscapes.The concept of mobile link organisms, i.e. key species that connect habitats and uphold their capacity to generate ecosystem services, is elaborated in relation to ecosystem dynamics and functioning. They are classified into resource, genetic and process linkers (Paper I). One such species, the Eurasian Jay (Garralus glandarius) and its role in oak tree regeneration across habitats, is empirically studied in a park of Stockholm (Paper II). The Jay is found to be pivotal in safeguarding the desired oak dominated landscape but its seed dispersal function requires active management, including of surrounding non-protected habitats. Potentially, a process oriented management approach could reduce costs and vulnerability to disturbances as well as preserve gene flow and diversity on a landscape level. Critical functions for ecosystem resilience performed by mobile links are likely to grow in importance as human impacts increase.The next focus is on ecosystems that are seldom considered in biological conservation and urban green space management. Ecosystem functions and services are identified in three types of culturally maintained land areas: golf courses, residential gardens, and allotments (Paper III). By GIS-assessment, it is established that they amount to 18% of the studied land area in metropolitan Stockholm, i.e. over twice the size of land set aside as protected areas. When these lands are taken into account, the cityscape appears to be greener than indicated by prevailing conservation maps. Focusing on the rapid expansion of golf courses in urban regions, the first major assessment of amphibian and macroinvertebrate fauna confined to golf courses is presented in Paper IV. Threatened species and those more sensitive to eutrophication, tended to be associated with golf ponds relative to ponds of other lands, including nature-protected areas. As to fauna, there was no significant difference between ponds of these different lands.Paper V further investigates culturally maintained areas such as sacred groves and military zones and considers them as under-explored assets for ecosystem and landscape management. They can perform essential complementary ecological functions and may even be instrumental in securing ecosystem services in fragmented landscapes. The social dimension of their sustenance is emphasized and it is argued that such lands and their steward groups should be explicitly incorporated into management through adaptive co-management schemes. Finally, the benefits of planting and managing an introduced alien cacti species (Opuntia spp.) in a highly fragmented landscape are examined by a case study from Madagascar (Paper VI). The cacti provide a range of ecosystem services vital to human subsistence in a location of scarce food and water supplies. Its extensive network of hedges reinforces landscape connectivity, e.g. exchanges between disconnected patches of sacred forest, rich in endemic plant species, and may support endemic wildlife. The thesis demonstrates the need for rethinking current conceptions in ecosystem management. Biotic linkages and the land uses researched may generate biodiversity benefits and ecosystem services rarely recognized in conservation, science or policy. The results imply that identifying and strengthening essential ecosystem processes could reduce the conflict between biodiversity conservation and societal development in urban and other human dominated landscapes. New avenues can be created that contribute to sustainable use of the human life-support systems.
|
|
| 25. |
|
|
| 26. |
- Lundberg, Stefan, et al.
(författare)
-
Miljöövervakningsstrategi för stormusslor : Utveckling av nationell miljöövervakning för sötvattenslevande stormusslor 2008
- 2008
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Naturhistoriska riksmuseet har tillsammans med Länsstyrelsen i Jönköpings län fått Naturvårdsverketsuppdrag att utreda och presentera en sammanställning om kunskapen kringstormusslorna i svenska sjöar och vattendrag, samt ge förslag på tillämpning inom nationellmiljöövervakning. Föreliggande utredning redovisar även hittills genomförd miljöövervakningsverksamhetavseende stormusslor i landet. Utredningen har genomförts under tidenaugusti 2007 till mars 2008.
|
|
| 27. |
- Manni, Giovanni Li, et al.
(författare)
-
The OpenMolcas Web : A Community-Driven Approach to Advancing Computational Chemistry
- 2023
-
Ingår i: Journal of Chemical Theory and Computation. - : American Chemical Society (ACS). - 1549-9618 .- 1549-9626. ; 19:20, s. 6933-6991
-
Tidskriftsartikel (refereegranskat)abstract
- The developments of the open-source OpenMolcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic structure theory, electronic spectroscopy simulations, analytic gradients and molecular structure optimizations, ab initio molecular dynamics, and other new features. This report offers an overview of the chemical phenomena and processes OpenMolcas can address, while showing that OpenMolcas is an attractive platform for state-of-the-art atomistic computer simulations.
|
|
| 28. |
- Muftee, Mehek
(författare)
-
“That will be your home” : Resettlement preparations for children and youth from the Horn of Africa
- 2014
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis analyzes how children and youth being resettled from Kenya and Sudan were prepared for their upcoming resettlement to Sweden, through cultural orientation programs (COPs). COPs are held for refugees who have been granted permanent Swedish residence and are undergoing resettlement to Sweden. The Swedish Migration Board, in charge of resettlement, carries out COPs as a means to inform and prepare refugees for the move to Sweden. This thesis is based on ethnographic work carried out during COPs held in Kenya and Sudan in 2011. Through video-based observation of the meetings between the Swedish delegations and children and youth, current thesis examines what notions of resettlement and refugeeness inform the delegations work, and how does the children’s agency come about during these meetings? The thesis includes three articles. Article 1 examines how the delegations make use of images in order to establish certain ideas of Sweden and the ideal citizen specifically tailored for the group being resettled. Article 2 explores children’s agency within the COPs, focusing on how the children and youth manage the meetings and sometimes resisting being positioned in certain ways by the delegations. Article 3 analyzes how notions of gender equality are drawn upon by the delegations during their work, a topic frequently highlighted by the delegations in various implicit and dilemmatic ways. The thesis shows how the delegations’ work is carried out in paradoxical ways. Their quest to bring forth the ideal future as a means to instill hope among the children simultaneously ends up categorizing them as different and as others. The representatives draw n ideas that the children need to be socialized in order to be incorporated into another “us”.
|
|
| 29. |
- Nordström, Jakob, et al.
(författare)
-
Crack detection methods and ranking for mining mill machinery
- 2009
-
Ingår i: 22nd International Congress on Condition Monitoring and Diagnostic Engineering Management. - Eibar : Fundaci n Tekniker. - 9788493206468 ; , s. 313-321
-
Konferensbidrag (refereegranskat)abstract
- The mining industry is severely exposed to various effects of the dynamic global business scenario today. The main issue for the mining industry is to maximize the availability of its machinery. Fatigue cracking in rotating mill machines is one of many critical factors in the context of function, safety, reliability and increased maintenance cost due to related unpredictable mill failures. There are several reasons for the appearance of cracks in mills. Several detection methods and technologies are available today, which are crack specific, depending on size and location. It is essential to select an appropriate crack detection method to fulfil the needs of the industries and the operational conditions, because each method has its own particular advantages and disadvantages. The main aim of this paper is to highlight the scopes and limitations of these methods. In this paper also the Analytical Hierarchical Process (AHP) is applied to determine the rank or unified measure for the selected crack detection methods. The aim of this analysis is to assist maintenance personnel in selecting the appropriate crack detection device.
|
|
| 30. |
|
|
| 31. |
- Sountoulidis, Alexandros, et al.
(författare)
-
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
- 2023
-
Ingår i: Nature Cell Biology. - : Springer Nature. - 1465-7392 .- 1476-4679.
-
Tidskriftsartikel (refereegranskat)abstract
- Sountoulidis et al. provide a spatial gene expression atlas of human embryonic lung during the first trimester of gestation and identify 83 cell identities corresponding to stable cell types or transitional states. The lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a comprehensive topographic atlas of early human lung development. Here we report 83 cell states and several spatially resolved developmental trajectories and predict cell interactions within defined tissue niches. We integrated single-cell RNA sequencing and spatially resolved transcriptomics into a web-based, open platform for interactive exploration. We show distinct gene expression programmes, accompanying sequential events of cell differentiation and maturation of the secretory and neuroendocrine cell types in proximal epithelium. We define the origin of airway fibroblasts associated with airway smooth muscle in bronchovascular bundles and describe a trajectory of Schwann cell progenitors to intrinsic parasympathetic neurons controlling bronchoconstriction. Our atlas provides a rich resource for further research and a reference for defining deviations from homeostatic and repair mechanisms leading to pulmonary diseases.
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
- Västermark, Åke, et al.
(författare)
-
Polymorphic variation in the androgen receptor gene : association with risk of testicular germ cell cancer and metastatic disease
- 2011
-
Ingår i: European Journal of Cancer. - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 47:3, s. 413-419
-
Tidskriftsartikel (refereegranskat)abstract
- Increasing incidence of testicular germ cell cancer (TGCC) is most probably related to environment and lifestyle. However, an underlying genetic predisposition may play a role and since sex steroids are assumed to be important for the rise and progression of TGCC, a study of androgen receptor (AR) gene polymorphisms in relation to the risk, histological type and progression of TGCC was undertaken. In 367 TGCC cases and 214 controls, AR CAG and GGN repeat lengths were determined and 11 haplotype-tagging single nucleotide polymorphisms (SNPs) were genotyped. By binary logistic regression, odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the risk of TGCC, non-seminoma versus seminoma and metastatic versus localised (stage I) disease. For the non-coding SNP, rs12014709, the minor genotype (G) was found in 10% of the cases and in 5.1% of the controls, conferring an OR of 2.07 (95% CI: 1.03-4.15) for having TGCC. Furthermore, short GGN (<23) was associated with an increased risk of metastatic disease (OR: 2.15; 95% CI: 1.04-4.45). The AR polymorphisms found by us might be involved in gene-environment interaction by increasing the susceptibility to the effect of endocrine disruptors. From a biological point of view, our findings strengthen the hypothesis of the importance of androgen action in the aetiology and pathogenesis of testicular malignancy. Future studies should focus on the impact of sex hormones on foetal germ cell development and the interaction between environmental factors and androgen receptor variants in relation to the risk of testicular malignancy.
|
|
