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1.	Agnarsson, Björn, 1977, et al. (författare) Evanescent Light-Scattering Microscopy for Label-Free Interfacial Imaging: From Single Sub-100 nm Vesicles to Live Cells 2015 Ingår i: ACS Nano. - : American Chemical Society (ACS). - 1936-086X .- 1936-0851. ; 9:12, s. 11849-11862 Tidskriftsartikel (refereegranskat)abstract Advancement in the understanding of biomolecular interactions has benefited greatly from the development of surface-sensitive bioanalytical sensors. To further increase their broad impact, significant efforts are presently being made to enable label-free and specific biomolecule detection with high sensitivity, allowing for quantitative interpretation and general applicability at low cost. In this work, we have addressed this challenge by developing a waveguide chip consisting of a flat silica core embedded in a symmetric organic cladding with a refractive index matching that of water. This is shown to reduce stray light (background) scattering and thereby allow for label-free detection of faint objects, such as individual sub-20 rim gold nanoparticles as well as sub-100 nm lipid vesicles. Measurements and theoretical analysis revealed that light-scattering signals originating from single surface-bound lipid vesicles enable characterization of their sizes without employing fluorescent lipids as labels. The concept is also demonstrated for label-free measurements of protein binding to and enzymatic (phospholipase A2) digestion of individual lipid vesicles, enabling an analysis of the influence on the measured kinetics of the dye-labeling of lipids required in previous assays. Further, diffraction-limited imaging of cells (platelets) binding to a silica surface showed that distinct subcellular features could be visualized and temporally resolved during attachment, activation, and spreading. Taken together, these results underscore the versatility and general applicability of the method, which due to its simplicity and compatibility with conventional microscopy setups may reach a widespread in life science and beyond.
2.	Agnarsson, Björn, 1977, et al. (författare) Waveguide structure 2018 Patent (övrigt vetenskapligt/konstnärligt)abstract A waveguide structure for evanescent wave microscopy and/or spectroscopy, comprising an optically transparent core layer, a lower dielectric cladding layer and an upper dielectric cladding layer arranged on opposite sides of the core layer. The core layer has a refractive index higher than the refractive indices of the cladding layers. The upper cladding layer is made of an organic material. A sample well is arranged on an upper surface of the core layer formed by a cavity in the upper cladding layer, the sample well being adapted to contain a sample medium with one or more sample objects. The core layer is made of a first dielectric inorganic material, and the upper cladding layer has a refractive index which closely matches the refractive index of the sample medium. A method for manufacturing such waveguide structure, and a measurement system comprising the waveguide structure are also disclosed.
3.	Blom, Björn, 1965-, et al. (författare) Register data in the evaluation and program planning of addiction treatment programs : using Sweden as an example 2015 Ingår i: Evaluation and Program Planning. - : Elsevier. - 0149-7189 .- 1873-7870. ; 49, s. 185-191 Tidskriftsartikel (refereegranskat)abstract Data from large-scale registers is often underutilized when evaluating addiction treatment programs. Since many programs collect register data regarding clients and interventions, there is a potential to make greater use of such records for program evaluation. The purpose of this article is to discuss the value of using large-scale registers in the evaluation and program planning of addiction treatment systems and programs. Sweden is used as an example of a country where register data is both available and is starting to be used in national evaluation and program planning efforts. The article focuses on possibilities, limitations and practicalities when using large-scale register data to conduct evaluations and program planning of addiction treatment programs. Main conclusions are that using register data for evaluation provides large amounts of data at low cost, limitations associated to the use of register data may be handled statistically, register data can answer important questions in planning of addiction treatment programs, and more accurate measures are needed to account for the diversity of client populations.
4.	Carlsson, Per-Anders, 1972, et al. (författare) Methane oxidation over supported noble metals-mechanistic consequences of transient operation 2011 Ingår i: Proceedings of the 22st North American Meeting Detroit, USA, June 5-11. Konferensbidrag (refereegranskat)
5.	Carlsson, Per-Anders, 1972, et al. (författare) Sulfur promoted methane oxidation over supported platinum catalysts 2012 Ingår i: Proceedings of the 9th International Congress on Catalysis and Automotive Pollution Control (CAPoC9), Brussels, Belgium, August 29-31. Konferensbidrag (refereegranskat)
6.	Dellmuth, Lisa, et al. (författare) State interests and bargaining power in the reform of the eurozone 2020 Rapport (övrigt vetenskapligt/konstnärligt)
7.	Dick Thelander, Kimberly, et al. (författare) Improving InAs nanotree growth with composition-controlled Au-In nanoparticles 2006 Ingår i: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 17:5, s. 1344-1350 Tidskriftsartikel (refereegranskat)abstract Au nanoparticles are commonly used as seeds for epitaxial growth of III-V semiconductor nanowires. However, the interaction between Au and In-containing III-V materials makes it difficult to control the growth of more complex nanowire structures in materials such as InAs. Here we report the growth of InAs nanowires and branched nanotrees using Au and Au-In nanoparticles. We show that the initial composition of the particle does not affect the morphology of the first-generation nanowires, nor does it affect the final composition of the particle after growth. However, when the Au-In particles were used to seed a second generation of nanowires, producing nanotrees, the branches exhibited a 2-3 times higher growth rate and more regular shape than those seeded by pure Au particles. This result is attributed to the decreased interaction between the seed particle and the trunk nanowires when Au-In particles are used. Thus the incorporation of In into the seed particle during particle production allows for modification of the particle-wire interaction.
8.	Engström, Terese, et al. (författare) Hormone receptor mRNA and protein levels as predictors of premenopausal tamoxifen benefit 2024 Ingår i: Acta Oncologica. - : Medical Journal Sweden AB. - 0284-186X .- 1651-226X. ; 63, s. 125-136 Tidskriftsartikel (refereegranskat)abstract Background and purpose: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomised tamoxifen trial, to evaluate their performance in identifying patients that benefit from tamoxifen. Patients and Methods: Premenopausal patients (n=564) were randomised to 2 years of tamoxifen or no systemic treatment. Estrogen receptor (ER) and progesterone receptor (PR) status by protein expression measured by cytosol-based methods and IHC, and mRNA by GEX analysis were compared in 313 patients with available data from all methods. Kaplan Meier estimates and Cox regression were used to evaluate the treatment-predictive value for recurrence-free interval (RFi) and overall survival (OS). Median follow-up for event-free patients was 26 (RFi) and 33 (OS) years. Results: The mRNA data of ESR1 and PGR distributed bimodally, patterns confirmed in an independent cohort. Kappa-values between all methods were 0.76 and 0.79 for ER and PR, respectively. Tamoxifen improved RFi in patients with ER-positive (ER+) or PR-positive (PR+) tumours (Hazard Ratio [HR] and 95% confidence interval [CI]), cytosol-ER+ 0.53 [0.36–0.79]; IHC-ER+ 0.55 [0.38–0.79]; GEX-ER+ 0.54 [0.37–0.77]; cytosol-PR+ 0.49 [0.34–0.72]; IHC-PR+ 0.58 [0.40–0.85]; GEX-PR+ 0.55 [0.38–0.80]). Results were similar for OS. Interpretation: These methods can all identify patients that benefit from 2 years of tamoxifen with equal performance, indicating that GEX data might be used to guide adjuvant tamoxifen therapy.
9.	Evertsson, Jonas, et al. (författare) Anodization of Al(100), Al(111) and Al Alloy 6063 studied in situ with X-ray reflectivity and electrochemical impedance spectroscopy 2017 Ingår i: Journal of Electroanalytical Chemistry. - : Elsevier BV. - 1572-6657. ; 799, s. 556-562 Tidskriftsartikel (refereegranskat)abstract We present results from the anodization of single crystal Al(100) and Al(111) surfaces and the aluminum alloy AA 6063 studied in situ by X-ray reflectivity and electrochemical impedance spectroscopy. We observe that the anodic oxide layer grows linearly with the anodization potential and that the thicknesses are similar for all samples. However, the thicknesses obtained from X-ray reflectivity are higher than that obtained from electrochemical impedance spectroscopy. We attribute the higher thicknesses to an outer porous oxide layer, which is not detected by electrochemical impedance spectroscopy. Both, electrochemical impedance spectroscopy and X-ray reflectivity suggests that a more heterogeneous and rough oxide is formed on AA 6063 due to the influence of the alloying elements and intermetallic particles during the growth.
10.	Evertsson, Jonas, et al. (författare) Self-organization of porous anodic alumina films studied in situ by grazing-incidence transmission small-angle X-ray scattering 2018 Ingår i: RSC Advances. - 2046-2069. ; 8:34, s. 18980-18991 Tidskriftsartikel (refereegranskat)abstract Self-ordered porous anodic alumina (PAA) films are studied extensively due to a large number of possible applications in nanotechnology and low cost of production. Whereas empirical relationships between growth conditions and produced oxides have been established, fundamental aspects regarding pore formation and self-organization are still under debate. We present in situ structural studies of PAA films using grazing-incidence transmission small-angle X-ray scattering. We have considered the two most used recipes where the pores self-organize: 0.3 M H2SO4 at 25 V and 0.3 M C2H2O4 at 40 V. During anodization we have followed the evolution of the structural parameters: average interpore distance, length of ordered pores domains, and thickness of the porous oxide layer. Compared to the extensively used ex situ investigations, our approach gives an unprecedented temporal accuracy in determination of the parameters. By using of Al(100), Al(110) and Al(111) surfaces, the influence of surface orientation on the structural evolution was studied, and no significant differences in the interpore distance and domain length could be observed. However, the rate of oxide growth in 0.3 M C2H2O4 at 40 V was significantly influenced by the surface orientation, where the slowest growth occurs for Al(111). In 0.3 M H2SO4 at 25 V, the growth rates were higher, but the influence of surface orientation was not obvious. The structural evolution was also studied on pre-patterned aluminum surfaces. These studies show that although the initial structures of the oxides are governed by pre-patterning geometry, the final structures are dictated by the anodization conditions.
11.	Evertsson, Jonas, et al. (författare) The thickness of native oxides on aluminum alloys and single crystals 2015 Ingår i: Applied Surface Science. - : Elsevier BV. - 1873-5584 .- 0169-4332. ; 349, s. 826-832 Tidskriftsartikel (refereegranskat)abstract We present results from measurements of the native oxide film thickness on four different industrial aluminum alloys and three different aluminum single crystals. The thicknesses were determined using X-ray reflectivity, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy. In addition, atomic force microscopy was used for micro-structural studies of the oxide surfaces. The reflectivity measurements were performed in ultra-high vacuum, vacuum, ambient, nitrogen and liquid water conditions. The results obtained using X-ray reflectivity and X-ray photoelectron spectroscopy demonstrate good agreement. However, the oxide thicknesses determined from the electrochemical impedance spectroscopy show a larger discrepancy from the above two methods. In the present contribution the reasons for this discrepancy are discussed. We also address the effect of the substrate type and the presence of water on the resultant oxide thickness.
12.	Furukawa, Toshi A., et al. (författare) Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression : a systematic review and component network meta-analysis using individual data 2021 Ingår i: Lancet psychiatry. - London, United Kingdom : Elsevier. - 2215-0374 .- 2215-0366. ; 8:6, s. 500-511 Forskningsöversikt (refereegranskat)abstract Findings We identified 76 RCTs, including 48 trials contributing individual participant data (11 704 participants) and 28 trials with aggregate data (6474 participants). The participants' weighted mean age was 42.0 years and 12 406 (71%) of 17 521 reported were women. There was suggestive evidence that behavioural activation might be beneficial (iMD -1.83 [95% credible interval (CrI) -2.90 to -0.80]) and that relaxation might be harmful (1.20 [95% CrI 0.17 to 2.27]). Baseline severity emerged as the strongest prognostic factor for endpoint depression. Combining human and automated encouragement reduced dropouts from treatment (incremental odds ratio, 0.32 [95% CrI 0.13 to 0.93]). The risk of bias was low for the randomisation process, missing outcome data, or selection of reported results in most of the included studies, uncertain for deviation from intended interventions, and high for measurement of outcomes. There was moderate to high heterogeneity among the studies and their components. 511
13.	Garcia-Martinez, Fernando, et al. (författare) Structure Matters: Asymmetric CO Oxidation at Rh Steps with Different Atomic Packing 2022 Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 144:33, s. 15363-15371 Tidskriftsartikel (refereegranskat)abstract Curved crystals are a simple but powerful approach to bridge the gap between single crystal surfaces and nanoparticle catalysts, by allowing a rational assessment of the role of active step sites in gas-surface reactions. Using a curved Rh(111) crystal, here, we investigate the effect of A-type (square geometry) and B-type (triangular geometry) atomic packing of steps on the catalytic CO oxidation on Rh at millibar pressures. Imaging the crystal during reaction ignition with laser-induced CO2 fluorescence demonstrates a two-step process, where B-steps ignite at lower temperature than A-steps. Such fundamental dissimilarity is explained in ambient pressure X-ray photoemission (AP-XPS) experiments, which reveal partial CO desorption and oxygen buildup only at B-steps. AP-XPS also proves that A-B step asymmetries extend to the active stage: at A-steps, low-active O-Rh-O trilayers buildup immediately after ignition, while highly active chemisorbed O is the dominant species on B-type steps. We conclude that B-steps are more efficient than A-steps for the CO oxidation.
14.	Gericke, Sabrina M., et al. (författare) Effect of Different In 2 O 3 (111) Surface Terminations on CO 2 Adsorption 2023 Ingår i: ACS Applied Materials & Interfaces. - 1944-8252 .- 1944-8244. ; 15:38, s. 45367-45377 Tidskriftsartikel (refereegranskat)abstract In2O3-based catalysts have shown high activity and selectivity for CO2 hydrogenation to methanol; however, the origin of the high performance of In2O3 is still unclear. To elucidate the initial steps of CO2 hydrogenation over In2O3, we have combined X-ray photoelectron spectroscopy and density functional theory calculations to study the adsorption of CO2 on the In2O3(111) crystalline surface with different terminations, namely, the stoichiometric, reduced, and hydroxylated surface. The combined approach confirms that the reduction of the surface results in the formation of In adatoms and that water dissociates on the surface at room temperature. A comparison of the experimental spectra and the computed core-level shifts (using methanol and formic acid as benchmark molecules) suggests that CO2 adsorbs as a carbonate on all three surface terminations. We find that the adsorption of CO2 is hindered by hydroxyl groups on the hydroxylated surface.
15.	Gericke, Sabrina M., et al. (författare) Effect of Different In2O3(111) Surface Terminations on CO2 Adsorption 2023 Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 15:38, s. 45367-45377 Tidskriftsartikel (refereegranskat)abstract In2O3-based catalysts have shown high activity and selectivity for CO2 hydrogenation to methanol; however, the origin of the high performance of In2O3 is still unclear. To elucidate the initial steps of CO2 hydrogenation over In2O3, we have combined X-ray photoelectron spectroscopy and density functional theory calculations to study the adsorption of CO2 on the In2O3(111) crystalline surface with different terminations, namely, the stoichiometric, reduced, and hydroxylated surface. The combined approach confirms that the reduction of the surface results in the formation of In adatoms and that water dissociates on the surface at room temperature. A comparison of the experimental spectra and the computed core-level shifts (using methanol and formic acid as benchmark molecules) suggests that CO2 adsorbs as a carbonate on all three surface terminations. We find that the adsorption of CO2 is hindered by hydroxyl groups on the hydroxylated surface.
16.	Ghadami Yazdi, Milad, et al. (författare) Structure dependent effect of silicon on the oxidation of Al(111) and Al(100) 2019 Ingår i: Surface Science. - : Elsevier. - 0039-6028 .- 1879-2758. ; 684, s. 1-11 Tidskriftsartikel (refereegranskat)abstract The effect of sub-monolayer silicon on the oxidation of Al(111) and Al(100) surfaces was investigated using X-ray Photoelectron Spectroscopy (XPS) and density functional theory (DFT) calculations. On both surfaces the adatom site is preferred over substituting Si into the Al-lattice; on Al(100) the four fold hollow site is vastly favored whereas on Al(111) bridge and hollow sites are almost equal in energy. Upon O 2 exposure, Si is not oxidized but buried at the metal/oxide interface under the growing aluminum oxide. On Al(111), Si has a catalytic effect on both the initial oxidation by aiding in creating a higher local oxygen coverage in the early stages of oxidation and, in particular, at higher oxide coverages by facilitating lifting Al from the metal into the oxide. The final oxide, as measured from the Al2p intensity, is 25–30% thicker with Si than without. This observation is valid for both 0.1 monolayer (ML) and 0.3 ML Si coverage. On Al(100), on the other hand, at 0.16 ML Si coverage, the initial oxidation is faster than for the bare surface due to Si island edges being active in the oxide growth. At 0.5 ML Si coverage the oxidation is slower, as the islands coalesce and he amount of edges reduces. Upon oxide formation the effect of Si vanishes as it is overgrown by Al 2 O 3 , and the oxide thickness is only 6% higher than on bare Al(100), for both Si coverages studied. Our findings indicate that, in addition to a vanishing oxygen adsorption energy and Mott potential, a detailed picture of atom exchange and transport at the metal/oxide interface has to be taken into account to explain the limiting oxide thickness.
17.	Grooten, Liset, et al. (författare) A scaling-up strategy supporting the expansion of integrated care : a study protocol 2019 Ingår i: Journal of Integrated Care. - : Emerald Group Publishing Limited. - 1476-9018. ; 27:3, s. 215-231 Tidskriftsartikel (refereegranskat)abstract PurposeTo ensure that more people will benefit from integrated care initiatives, scaling-up of successful initiatives is the way forward. However, new challenges present themselves as knowledge on how to achieve successful large-scale implementation is scarce. The EU-funded project SCIROCCO uses a step-based scaling-up strategy to explore what to scale-up, and how to scale-up integrated care initiatives by matching the complementary strengths and weaknesses of five European regions involved in integrated care. The purpose of this paper is to describe a multi-method evaluation protocol designed to understand what factors influence the implementation of the SCIROCCO strategy to support the scaling-up of integrated care.Design/methodology/approachThe first part of the protocol focuses on the assessment of the implementation fidelity of the SCIROCCO step-based strategy. The objective is to gain insight in whether the step-based strategy is implemented as it was designed to explore what works and does not work when implementing the scaling-up strategy. The second part concerns a realist evaluation to examine what it is about the SCIROCCO’s strategy that works for whom, why, how and in which circumstances when scaling-up integrated care.FindingsThe intended study will provide valuable information on the implementation of the scaling-up strategy which will help to explain for what specific reasons the implementation succeeds and will facilitate further improvement of project outcomes.Originality/valueThe expected insights could be useful to guide the development, implementation and evaluation of future scaling-up strategies to advance the change towards more sustainable health and care systems.
18.	Hall, Taylor, et al. (författare) Mortality among a national population sentenced to compulsory care for substance use disorders in Sweden : Descriptive study 2015 Ingår i: Evaluation and Program Planning. - : Elsevier. - 0149-7189 .- 1873-7870. ; 49, s. 153-162 Tidskriftsartikel (refereegranskat)abstract Sweden's compulsory addiction system treats individuals with severe alcohol and narcotics use disorders. Merging data from three national level register databases of those sentenced to compulsory care from 2001 to 2009 (n = 4515), the aims of this study were to: (1) compute mortality rates to compare to the general Swedish population; (2) identify leading cause of mortality by alcohol or narcotics use; and (3) identify individual level characteristics associated with mortality among alcohol and narcotics users. In this population, 24% were deceased by 2011. The most common cause of death for alcohol users was physical ailments linked to alcohol use, while narcotics users commonly died of drug poisoning or suicide. Average age of death differed significantly between alcohol users (55.0) and narcotics users (32.5). Multivariable logistic regression analysis identified the same three factors predicting mortality: older age (alcohol users OR = 1.28, narcotic users OR = 1.16), gender [males were nearly 3 times more likely to die among narcotics users (p < .000) acid 1.6 times more likely to die among alcohol users (p < .01)] and reporting serious health problems (for alcohol users p < .000, for narcotics users p < .05). Enhanced program and government efforts are needed to implement overdose-prevention efforts and different treatment modalities for both narcotic and alcohol users. (C) 2014 Elsevier Ltd. All rights reserved.
19.	Johansson, Helena, et al. (författare) Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome in clinical islet transplantation 2005 Ingår i: Diabetes. ; 54:6, s. 1755-62 Tidskriftsartikel (refereegranskat)
20.	Johansson, Helena, et al. (författare) Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation 2005 Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 54:6, s. 1755-62 Tidskriftsartikel (refereegranskat)abstract There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced by the endocrine cells. In the present study, we show that islets intended for islet transplantation produce tissue factor in both the transmembrane and the alternatively spliced form and that the membrane-bound form is released as microparticles often associated with both insulin and glucagon granules. A low-molecular mass factor VIIa (FVIIa) inhibitor that indirectly blocks both forms of tissue factor was shown in vitro to be a promising drug to eliminate the IBMIR. Thrombin-antithrombin complex (TAT) and FVIIa-antithrombin complex (FVIIa-AT) were measured in nine patients who together received 20 infusions of isolated human islets. Both the TAT and FVIIa-AT complexes increased rapidly within 15-60 min after infusion. When the initial TAT and FVIIa-AT levels were plotted against the increase in C-peptide concentration after 7 days, patients with an initially strong IBMIR showed no significant increase in insulin synthesis after 7 days. In conclusion, tissue factor present in both the islets and the culture medium and elicits IBMIR, which affects the function of the transplanted islets.
21.	Kashioulis, Pavlos, 1980, et al. (författare) Adenine-Induced Chronic Renal Failure in Rats: A Model of Chronic Renocardiac Syndrome with Left Ventricular Diastolic Dysfunction but Preserved Ejection Fraction 2018 Ingår i: Kidney & Blood Pressure Research. - : S. Karger AG. - 1420-4096 .- 1423-0143. ; 43:4, s. 1053-1064 Tidskriftsartikel (refereegranskat)abstract Background/Aims: Cardiovascular disease is the major cause of death in patients with chronic kidney disease (CKD). Rats with adenine-induced chronic renal failure (ACRF) develop severe renal insufficiency and metabolic abnormalities that closely resemble those in patients with uremia. The aim of the present study was to determine left ventricular (LV) morphology and function in rats with ACRF. Methods: Male Sprague-Dawley rats received either chow containing adenine or were pair-fed an identical diet without adenine (controls, C). After 9-13 weeks animals were anesthetized with isoflurane and cardiac function was assessed both by echocardiography and by LV catheterization. Results: Rats with ACRF showed increases in serum creatinine (323 +/- 107 vs. 33 +/- 5 pM, P<0.05), mean arterial pressure (115 +/- 6 vs. 106 +/- 7 mmHg, P<0.05) and LV weight (3.4 +/- 0.3 vs. 2.5 +/- 0.2 mg/kg, P<0.05) vs. controls. Rats with ACRF had reduced early diastolic tissue Doppler velocities in the LV, enlarged left atrial diameter (4.8 +/- 0.8 vs. 3.5 +/- 0.4 mm, P<0.05) and elevated LV end-diastolic pressure (15 +/- 5 vs. 8 +/- 1 mmHg, P <0.01). Cardiac output was increased in ACRF rats (211 +/- 66 vs. 149 +/- 24 ml/min, P <0.05) and systolic function preserved. In the LV of ACRF rats there were statistically significant (P<0.05) increases in cardiomyocyte diameter, proliferation and apoptosis, while there was no difference between groups in fibrosis. Conclusion: Rats with ACRF develop LV hypertrophy and diastolic dysfunction while systolic performance was preserved. There was an increased hypertrophy and apoptosis of cardiomyocytes in the LV of ACRF rats. The cardiac abnormalities in ACRF rats resemble those in patients with CKD in which heart failure with preserved ejection fraction is common. Hence, this experimental model is well suited for studying pathophysiological mechanisms in chronic renocardiac syndromes. (C) 2018 The Author(s) Published by S. Karger AG, Basel
22.	Kotze, Shelley, 1986, et al. (författare) Trusting constructive madness 2019 Ingår i: Dymitrow, M. and Ingelhag, K. (eds.), Anatomy of a 21st-century sustainability project: The untold stories. - Gothenburg : Mistra Urban Futures / Chalmers University of Technology. - 9789198416633 ; , s. 116-120 Bokkapitel (refereegranskat)
23.	Kuklane, Kalev, et al. (författare) Evaluation of BARRIER® EasyWarm on healthy volunteers in three different climates 2016 Ingår i: ; , s. 53-55 Konferensbidrag (refereegranskat)
24.	Kuklane, Kalev, et al. (författare) Evaluation of BARRIER® EasyWarm on Healthy Volunteers in Three Different Climates and Verification of the Degree of Correlation Between Tests Performed on Healthy Volunteers and in a standardized bench test 2015 Rapport (övrigt vetenskapligt/konstnärligt)abstract INTRODUCTION Anaesthesia induced hypothermia is a common serious but preventable condition associated with increased bleeding and blood transfusion, increased risk for surgical site infections and increased risk for morbid cardiac events. Active warming is effective in preventing hypothermia but there is a need for more easy to use cost-effective products making active warming available to more patients. Establishing how the environment affects skin temperature and total body heat content (TBHC) as well as the correlation between standardized bench tests and healthy volunteer skin temperature is an important aspect in developing new, more effective warming products to prevent or treat hypothermia as this means fewer healthy volunteers are needed as changes to skin temperature could be estimated based on data from bench tests. OBJECTIVES This investigation was undertaken in order to investigate the safety and efficacy of Active warming with BARRIER® EasyWarm when used in three different climate settings and using different test methods; standardized bench test T-1127 measuring temperatures on a wooden board and measuring skin and core temperature on healthy volunteers. An additional objective in this investigation was to determine the degree of correlation between these test methods. OUTCOME A statistically significant increase in TBHC is seen when comparing TBHC over time in all three climates, respectively. With this investigation design we cannot show that there is a difference in TBHC between the different climates though, i.e. the heat generated from the blanket to the subject is not significantly different in the different climates. Based on this investigation the active warming blanket managed to maintain or increase the temperature of the subjects without any adverse thermal effects. Thermal comfort and the mean thermal sensation were maintained between slightly cold and warm throughout the whole exposure length. The active self-warming blanket was well tolerated in healthy male volunteers. None of the six Adverse Events (AE) reported were serious and none of them were related to the investigational device but rather to the immobilisation or the tension of participating in the investigation. All AEs were resolved at end of test. Skin temperature reached maximally 42.2°C, and thus, it never reached the lowest pain threshold of 43°C under any conditions. Increase of core temperature over time in climate 18°C and 24°C was in average 0.1°C to 0.2°C leading to mean final core temperatures of 36.9 (SD 0.2) and 37.1 (SD 0.4) °C for 18°C and 24°C exposures, respectively.
25.	Larsson, Alfred, et al. (författare) In situ scanning x-ray diffraction reveals strain variations in electrochemically grown nanowires 2021 Ingår i: Journal of Physics D: Applied Physics. - : IOP Publishing. - 0022-3727 .- 1361-6463. ; 54:23 Tidskriftsartikel (refereegranskat)abstract Templated electrochemical growth in nanoporous alumina can be used to fabricate nanowires with applications in magnetic storage devices, hydrogen sensors, and electrocatalysis. It is known that nanowires, grown in such templates, are strained. The strain in nanoscale materials can influence their performance in applications such as catalysts and electronic devices. However, it is not well established how the nanoporous template affects the lattice strain in the nanowires and how this develops during the growth process due to the lack of non-destructive in situ studies with spatial resolution. We have measured the strain and grain size of palladium nanowires in nanoporous templates during the growth process. For this, we performed in situ scanning x-ray diffraction with a submicron focused x-ray beam. We found a tensile strain in the nanowires and that it is more pronounced along the growth direction than in the confined direction of the templates. The tensile strain measured in situ is higher than previous ex situ reports, possibly due to hydrogen absorption during the growth. With the spatial information made possible with the focused synchrotron x-ray beam, we could observe local variations in the strain as a function of height. A region of local strain variation is found near the bottom of the nanowires where growth is initiated in branches at the pore bottoms. Knowledge of how nanoporous templates influences the strain of the nanowires may allow for atomic scale tailoring of the catalytic activity of such nanowires or minimizing strain to optimize electronic device performance.
26.	Larsson, Anna Maria, et al. (författare) Longitudinal enumeration and cluster evaluation of circulating tumor cells improve prognostication for patients with newly diagnosed metastatic breast cancer in a prospective observational trial 2018 Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 20:1, s. 1-14 Tidskriftsartikel (refereegranskat)abstract Background: Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic information to CTC enumeration alone but their significance is unknown in patients with newly diagnosed MBC. We aimed to evaluate whether longitudinal enumeration of circulating tumor cells (CTCs) and CTC clusters could improve prognostication and monitoring of patients with metastatic breast cancer (MBC) starting first-line therapy. Methods: This prospective study included 156 women with newly diagnosed MBC. CTCs and CTC clusters were detected using CellSearch technology at baseline (BL) and after 1, 3, and 6months of systemic therapy. The primary end point was progression-free survival (PFS) and the secondary end point overall survival (OS). Median follow-up time was 25 (7-69) months. Results: There were 79 (52%) and 30 (20%) patients with ≥5 CTCs and≥1 CTC cluster at baseline, respectively; both factors were significantly associated with impaired survival. Landmark analyses based on follow-up measurements revealed increasing prognostic hazard ratios for ≥5 CTCs and CTC clusters during treatment, predicting worse PFS and OS. Both factors added value to a prognostic model based on clinicopathological variables at all time points and ≥5 CTCs and presence of CTC clusters enhanced the model's C-index to >0.80 at 1, 3, and 6months. Importantly, changes in CTCs during treatment were significantly correlated with survival and patients with a decline from ≥5 CTCs at BL to <5 CTCs at 1month had a similar odds ratio for progression to patients with <5 CTCs at BL and 1month. Stratification of patients based on CTC count and CTC clusters into four groups (0 CTCs, 1-4 CTCs, ≥5 CTCs, and ≥1 CTC+CTC clusters) demonstrated that patients with CTC clusters had significantly worse survival compared to patients without clusters. Conclusions: Longitudinal evaluation of CTC and CTC clusters improves prognostication and monitoring in patients with MBC starting first-line systemic therapy. The prognostic value increases over time, suggesting that changes in CTC count are clinically relevant. The presence of CTC clusters adds significant prognostic value to CTC enumeration alone.
27.	Lindén, Anna-Lisa, et al. (författare) Från ord till handling. Individuella möjligheter och samhälleliga restriktioner 1996 Ingår i: Livsstil och miljö. Fråga, forska, förändra.. - 9162011693 ; , s. 67-99 Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract I dagens läge finns en hel del kunskap om olika aspekter av miljöanpassade handlingssätt. Samtidigt har forskningen givit upphov till insikter om nya, ofta komplicerade frågor om förhållandet mellan människors värderingar, attityder i miljöfrågor och omställning till mera miljöanpassat beteende. I det här kapitlet kommer den kunskap om människors miljöhandlingar som finns i dag att diskuteras och knytas samman både med ”gamla” frågor som är obesvarade och sådana som aktualiserats av forskningen. Fyra huvudrubriker disponerar framställningen, nämligen livsstil; miljömedvetande, attityder och kunskap; miljöhandlingars sociala och demografiska kontext samt samhällens organisering och miljöhandlingars stabilitet.
28.	Lindén, Anna-Lisa, et al. (författare) Livsstil, miljö och miljöhandlingar - ett teoretiskt persepktiv 1992 Ingår i: Livsstil och miljö. På väg mot ett miljövänligt beteende?. - 9162011227 ; , s. 65-80 Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract Inom psykologi och sociologi har forskning kring människors livsstil sin bakgrund i klassiska forskningsfält. Ändå finner man att när man lämnar de inom ämnena klassiska beteendeområdena för livsstil saknas en helt täckande teoribildning. Klassiska teorier har dessutom i många fall blivit så väl kända även utanför forskarsamhället att de fått en mera allmän och ofta vag betydelse för att vara användbara som utgångspunkter för forskning. Precis så är det med både begreppet livsstil och teorier kring livsstil. Den teoretiska ramen måste preciseras på nytt för nya problem i en ny tid. Problemområdet för det här aktuella forskningsområdet är förhållandet mellan människors livsstil - miljö - miljöhandlingar. Vid en närmare granskning av de tre begreppen finner man att alla tre behöver precsieras och sättas in i ett större teoretiskt sammanhang för att bli användbara redskap i en empirisk analys.
29.	Linpé, Weronica, et al. (författare) Revisiting Optical Reflectance from Au(111) Electrode Surfaces with Combined High-Energy Surface X-ray Diffraction 2021 Ingår i: Journal of the Electrochemical Society. - : Electrochemical Society. - 0013-4651 .- 1945-7111. ; 168:9 Tidskriftsartikel (refereegranskat)abstract We have combined high-energy surface X-ray diffraction (HESXRD) with 2D surface optical reflectance (2D-SOR) to perform in situ electrochemical measurements of a Au(111) electrode in 0.1 M HClO4 electrolyte. We show that electrochemically induced changes to Au(111) surface during cyclic voltammetry can be simultaneously observed with 2D-SOR and HESXRD. We discuss how small one atom high 1x1 islands, accommodating excess atoms after the lifting of the surface reconstruction, can lead to discrepancies between the two techniques. The use of HESXRD allows us to simultaneously detect parts of the truncation rods from the (1 x 1) surface termination and the p x root 3 electrochemically induced surface reconstruction, during cyclic voltammetry. The presence of reconstruction phenomena is shown to not depend on having an ideally prepared surface and can in fact be observed after going to very oxidizing potentials. 2D-SOR can also detect the oxidation of the Au surface, however no oxide peaks are detected in the HESXRD signal, which is evidence that any Au oxide is X-ray amorphous.
30.	Lundgren, Christine, et al. (författare) Agreement between molecular subtyping and surrogate subtype classification : a contemporary population-based study of ER-positive/HER2-negative primary breast cancer 2019 Ingår i: Breast Cancer Research and Treatment. - : SPRINGER. - 0167-6806 .- 1573-7217. ; 178:2, s. 459-467 Tidskriftsartikel (refereegranskat)abstract Purpose: Oestrogen receptor-positive (ER+) and human epidermal receptor 2-negative (HER2-) breast cancers are classified as Luminal A or B based on gene expression, but immunohistochemical markers are used for surrogate subtyping. The aims of this study were to examine the agreement between molecular subtyping (MS) and surrogate subtyping and to identify subgroups consisting mainly of Luminal A or B tumours.Methods: The cohort consisted of 2063 patients diagnosed between 2013-2017, with primary ER+/HER2- breast cancer, analysed by RNA sequencing. Surrogate subtyping was performed according to three algorithms (St. Gallen 2013, Maisonneuve and our proposed Grade-based classification). Agreement (%) and kappa statistics (kappa) were used as concordance measures and ROC analysis for luminal distinction. Ki67, progesterone receptor (PR) and histological grade (HG) were further investigated as surrogate markers.Results: The agreement rates between the MS and St. Gallen 2013, Maisonneuve and Grade-based classifications were 62% (kappa = 0.30), 66% (kappa = 0.35) and 70% (kappa = 0.41), respectively. PR did not contribute to distinguishing Luminal A from B tumours (auROC = 0.56). By classifying HG1-2 tumours as Luminal A-like and HG3 as Luminal B-like, agreement with MS was 80% (kappa = 0.46). Moreover, by combining HG and Ki67 status, a large subgroup of patients (51% of the cohort) having > 90% Luminal A tumours could be identified.Conclusions: Agreement between MS and surrogate classifications was generally poor. However, a post hoc analysis showed that a combination of HG and Ki67 could identify patients very likely to have Luminal A tumours according to MS.
31.	Lundgren, Christine, et al. (författare) PAM50 subtyping and ROR score add long-term prognostic information in premenopausal breast cancer patients 2022 Ingår i: Npj Breast Cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 8:1 Tidskriftsartikel (refereegranskat)abstract PAM50 intrinsic subtyping and risk of recurrence (ROR) score are approved for risk profiling in postmenopausal women. We aimed to examine their long-term prognostic value in terms of breast cancer-free interval (BCFi) and overall survival (OS) (n = 437) in premenopausal women randomised to 2 years of tamoxifen versus no systemic treatment irrespective of hormone-receptor status. Intrinsic subtyping added independent prognostic information in patients with oestrogen receptor-positive/human epidermal growth factor 2-negative tumours for BCFi and OS after maximum follow-up (overall P-value 0.02 and 0.006, respectively) and those with high versus low ROR had worse prognosis (maximum follow-up: hazard ratio (HR)(BCFi): 1.70, P 0.04). The prognostic information by ROR was similar regarding OS and in multivariable analysis. These results support that PAM50 subtyping and ROR score provide long-term prognostic information in premenopausal women. Moreover, tamoxifen reduced the incidence of breast cancer events only in patients with Luminal A(PAM50) tumours (0-10 years: HRBCFi(Luminal A): 0.41, HRBCFi(Luminal B): 1.19, P-interaction = 0.02).
32.	Lundgren, Christine, et al. (författare) Tamoxifen-predictive value of gene expression signatures in premenopausal breast cancer : data from the randomized SBII:2 trial 2023 Ingår i: Breast Cancer Research. - : BMC. - 1465-5411 .- 1465-542X. ; 25:1 Tidskriftsartikel (refereegranskat)abstract Background: Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and prognostic effects of different GEX signatures in premenopausal women with early breast cancer. Methods: RNA from formalin-fixed paraffin-embedded tumor tissue from premenopausal women randomized between two years of tamoxifen treatment and no systemic treatment was extracted and successfully subjected to GEX profiling (n = 437, NanoString Breast Cancer 360™ panel). The median follow-up periods for a recurrence-free interval (RFi) and overall survival (OS) were 28 and 33 years, respectively. Associations between GEX signatures and tamoxifen effect were assessed in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+ /HER2−) tumors using Kaplan–Meier estimates and Cox regression. The prognostic effects of GEX signatures were studied in the entire cohort. False discovery rate adjustments (q-values) were applied to account for multiple hypothesis testing. Results: In patients with ER+/HER2− tumors, FOXA1 expression below the median was associated with an improved effect of tamoxifen after 10 years with regard to RFi (hazard ratio [HR] FOXA1(high) = 1.04, 95% CI = 0.61–1.76, HR FOXA1(low) = 0.30, 95% CI = 0.14–0.67, q interaction = 0.0013), and a resembling trend was observed for AR (HR AR(high) = 1.15, 95% CI = 0.60–2.20, HR AR(low) = 0.42, 95% CI = 0.24–0.75, q interaction = 0.87). Similar patterns were observed for OS. Tamoxifen was in the same subgroup most beneficial for RFi in patients with low ESR1 expression (HRRFi ESR1(high) = 0.76, 95% CI = 0.43–1.35, HRRFi, ESR1(low) = 0.56, 95% CI = 0.29–1.06, q interaction = 0.37). Irrespective of molecular subtype, higher levels of ESR1, Mast cells, and PGR on a continuous scale were correlated with improved 10 years RFi (HR ESR1 = 0.80, 95% CI = 0.69–0.92, q = 0.005; HRMast cells = 0.74, 95% CI = 0.65–0.85, q < 0.0001; and HR PGR = 0.78, 95% CI = 0.68–0.89, q = 0.002). For BC proliferation and Hypoxia, higher scores associated with worse outcomes (HRBCproliferation = 1.54, 95% CI = 1.33–1.79, q < 0.0001; HRHypoxia = 1.38, 95% CI = 1.20–1.58, q < 0.0001). The results were similar for OS. Conclusions: Expression of FOXA1 is a promising predictive biomarker for tamoxifen effect in ER+/HER2− premenopausal breast cancer. In addition, each of the signatures BC proliferation, Hypoxia, Mast cells, and the GEX of AR, ESR1, and PGR had prognostic value, also after adjusting for established prognostic factors. Trial registration This trial was retrospectively registered in the ISRCTN database the 6th of December 2019, trial ID: https://clinicaltrials.gov/ct2/show/ISRCTN12474687 .
33.	Lundgren, Christine, et al. (författare) Tumour-infiltrating lymphocytes as a prognostic and tamoxifen predictive marker in premenopausal breast cancer : data from a randomised trial with long-term follow-up 2020 Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 22:1 Tidskriftsartikel (refereegranskat)abstract Background: Tumour-infiltrating lymphocytes (TILs) are of important prognostic and predictive value in human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) and triple-negative breast cancer (TNBC), but their clinical relevance in oestrogen receptor-positive/HER2-negative (ER+/HER2−) remains unknown. The primary study aim was to analyse the prognostic effect of TILs on the BC-free interval (BCFi) in premenopausal patients stratified by BC subtypes. The secondary aim was to investigate if TILs are predictive of tamoxifen (TAM) benefit. Methods: Archival tissues from primary breast tumours were collected from patients from the SBII:2pre trial, in which 564 premenopausal women were randomised to 2 years of adjuvant TAM or no systemic treatment, regardless of hormone receptor status. TILs were scored on whole tissue sections from 447 patients with available ER status. Tumours were divided into ER+/HER2−, HER2+ and TNBC subtypes by immunohistochemistry and in situ hybridisation. The prognostic value of TILs was analysed in systemically untreated patients (n = 221); the predictive information was investigated in the ER+ subgroup (n = 321) by cumulative incidence curves and Cox regression analyses. The median follow-up was 28 years. Results: High (≥ 50%) infiltration of TILs was a favourable prognostic factor in terms of BCFi (univariable analysis: hazard ratioBCFi (HRBCFi) 0.40; 95% confidence interval (CI) 0.22–0.71; P = 0.002). Similar effects were observed across all BC subtypes. The effect of adjuvant TAM was stronger in patients with ER+ tumours and TILs < 50% (HRBCFi 0.63; 95% CI 0.47–0.84; P = 0.002) than in patients with high immune infiltration (≥ 50%) (HRBCFi 0.84; 95% CI (0.24–2.86); P = 0.77). However, evidence for differential effects of TAM in categories of TILs, i.e. interaction, was weak. Conclusions: We demonstrate a long-term favourable prognostic value of high infiltration of TILs in a cohort of premenopausal BC patients and the positive prognostic effect was extended to the ER+/HER2− subgroup. A beneficial effect of TAM in ER+ patients was observed in patients with tumours of low TIL infiltration, but evidence for a treatment predictive effect was weak. Trial registration: This trial is registered in the ISRCTN database, trial ID: ISRCTN12474687.
34.	Lundgren, Eva-Lisa (författare) Knowledge, familiarity and perceived quality of care : midwives' knowledge of and women's experience with population-based cervical screening programme in Stockholm 2006 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract The current study is part of an interdisciplinary project on population-based screening for cervical cancer, entitled "Between Sickness and Health: A Multidisciplinary Study of a Population-based Cervical Screening Programme in the Stockholm-Gotland Region". This interdisciplinary research project commenced in 1995 in order to generate a multi-facetted overview of cervical cancer screening. In this part of the research project, an investigation was made into midwives' knowledge of and familiarity with cancer and cancer prevention (subsidiary study I) and how women participating in screening evaluate the health care received at follow-up appointments with midwives (subsidiary study II). Subsidiary study I. The purpose of this article was to investigate how midwives describe their work with cervical cancer screening, their familiarity with the disease and it prevention. Twenty-one midwives from seven gynaecological clinics participated in a qualitative interview study. A semi-structured questionnaire was used to examine the attitudes of the midwives in regard to the risks and benefits of the screening programme, the at-risk factors for cervical cancer, test reliability, "sources" of information/knowledge relevant to cervical cancer and screening, and how the midwives describe their roll in the screening programme. The results showed that the midwives saw themselves as having an important role in regard to women's health, and their own confidence in their ability to receive patients also reflected a sense of having a central and important role within the screening programme. In regard to the midwives' assessment of risks and benefits of the work with cancer screening, it was revealed that they felt there were gaps in their knowledge of gynaecological cancer, the processes surrounding the test and that they lacked feedback. The midwives stated that they lacked relevant knowledge about cancer and cancer prevention, but felt they were very familiar with the testing technique. They felt that there was a lack of further professional development in these areas after completion of their midwifery training. Subsidiary study II. The purpose of this article was to describe the quality of care and patient satisfaction in a population-based cervical cancer screening programme for women with documented cell abnormality. The women in the screening programme whose pap-smear tests revealed varying degrees of cell abnormality were referred directly from the pathology/cytology lab to a gynaecological clinic. The women were then given an appointment for examination and further investigation. Many women had to wait for the test results and an appointment with the gynaecologist, the wait being anything from a couple of weeks to six months. In 1996, the Stockholm-Gotland Oncology Centre initiated a pilot scheme in which women with abnormal cell tests were contacted by a midwife at the maternity clinic. The midwife had an additional meeting with the women to give them information about their abnormal test results and they were given the opportunity to ask questions and continue to discuss health care. In order to evaluate the women's perceptions of this care, a follow-up survey was conducted using the questionnaire QPP (quality from a patient perspective). The model describes quality of care in four dimensions: medical-technical competence, physical-technical competence, identity-orientation in attitudes and actions, and socio-cultural atmosphere. In this study, questions related to physical-technical competence were excluded as they were not relevant. One context-specific factor with four questions was added. In total, the questionnaire contained twenty six questions measuring eight factors in three dimensions, plus the four context-specific questions. Seventy-five women with cell morphology answered the questionnaire. Thirty-seven of these women (the intervention group) had received one additional meeting with a midwife to enhance but not replace the information provided by the gynaecologist The remaining thirty-eight women (control group) only received standard appointments for examination and discussion with the gynaecologist. The results for the whole group of women showed that the most highly rated aspects of perceived reality were medical care, information prior to intervention, respect and privacy. The aspects of perceived reality that were most poorly rated were involvement, interest, empathy and post-intervention information. The factors that were most highly rated in relation to perceived reality also had the highest quality index, whereas those that were most poorly rated had the lowest quality index. The greatest difference between the groups (intervention and control groups) lay in the personal quality index, and only for the context-specific statement: "I had the opportunity to discuss my health with the midwife". The personal quality index for the intervention group indicated moderate satisfaction with care whilst for the control group, the index indicated less satisfaction. The women who had been offered an additional meeting with a midwife were more satisfied with the information received from the gynaecologist, their own level of self-care, the physical environment of the gynaecological clinic and the gynaecologist's knowledge of the test. The results also indicate that more attention can be given to psycho-social aspects such as participation in decision-making, empathy and being in control.
35.	Lundgren, Julie S, et al. (författare) Perceptions of facilitators, barriers and solutions when preparing to implement a home visiting program in Sweden: a mixed-methods study. 2024 Ingår i: Frontiers in health services. - 2813-0146. ; 4 Tidskriftsartikel (refereegranskat)abstract Although there is growing awareness that early childhood development programs are important for a sustainable society, there is a knowledge gap about how to implement such programs. Successful implementation requires attention to implementation drivers (competency, organization, and leadership) during all phases of the implementation. The purpose of this study was to describe cross-sectoral operational workgroups' perceptions of facilitators, barriers and solutions related to implementation drivers in the preparationphase of implementing an evidence-based early childhood home visiting program.Quantitative and qualitative data were collected from twenty-four participants, divided into 5 groups, during implementation planning workshops. The workshops were guided by a structured method informed by the principles of Motivational Interviewing and within a framework of implementation drivers. Groups sorted cards with statements representing implementation drivers according to perceptions of facilitators and barriers, and percentages were calculated for each type of implementation determinant, for each type of driver. The groups discussed their card sorting and wrote action plans to address barriers, yielding documentation that was analyzed using deductive qualitative content analysis.A mixed-methods analysis resulted identification of facilitators, barriers, unknowns and solutions in two to three subcategories under each main category of implementation driver. A competent and confident workforce, and enthusiasm and commitment were key facilitators. Key barriers were unclear roles and responsibilities, and insufficient articulation of local vision and goals. Many factors were described as yet unknown. Specific solutions were generated to support the implementation.Our study furthers the scientific understanding of how to take evidence-based early childhood programs from research to practice within an implementation drivers framework. Facilitators, barriers and solutions in key areas during the preparation phase were identified with the help of a novel tool. The results provide useful knowledge for decision makers and organizations preparing similar initiatives in communities striving to attain sustainable development goals.
36.	Lundgren, Katja, et al. (författare) Stromal Expression of beta-Arrestin-1 Predicts Clinical Outcome and Tamoxifen Response in Breast Cancer 2011 Ingår i: Journal of Molecular Diagnostics. - : American Society for Investigative Pathology (ASIP). - 1525-1578 .- 1943-7811. ; 13:3, s. 340-351 Tidskriftsartikel (refereegranskat)abstract The G-protein coupled receptor associated protein beta-arrestin-1 is crucial for the regulation of numerous biological processes involved in cancer progression, such as intracellular signaling and cell motility. The encoding gene ARRB1 is harbored in the same chromosomal region as the CCND1 gene (11q13). Amplification of CCND1, frequently encountered in breast cancer, often involves coamplification of additional oncogenes, as well as deletion of distal 11q genes. We investigated the clinical relevance of beta-arrestin-1 in breast cancer and elucidated a potential link between beta-arrestin-1 expression and CCND1 amplification. beta-Arrestin-1 protein expression was evaluated in two breast cancer patient cohorts, comprising 179 patients (cohort I) and 500 patients randomized to either tamoxifen or no adjuvant treatment (cohort H). Additionally, migration after beta-arrestin-1 overexpression or silencing was monitored in two breast cancer cell lines. Overexpression of beta-arrestin-1 reduced the migratory propensity of both cell lines, whereas silencing increased migration. In cohort I, high expression of stromal beta-arrestin-1 was linked to reduced patient survival, whereas in cohort II both high and absent stromal expression predicted a poor clinical outcome. Patients exhibiting low or moderate levels of stromal beta-arrestin-1 did not benefit from tamoxifen, in contrast to patients exhibiting absent or high expression. Furthermore, CCND1 amplification was inversely correlated with tumor cell expression of beta-arrestin-1, indicating ARRB1 gene deletion in CCND1-amplified breast cancers.
37.	Lundgren, Lina, et al. (författare) Biomechanics of extreme sports - a kite surfing scenario 2007 Ingår i: NES2007 Abstracts. - : Nordic Ergonomics Society. ; , s. s.169- Konferensbidrag (refereegranskat)abstract Do extreme sports contribute to higher biomechanical stress compared to other sports? Kite surfing is one of the upcoming popular extreme sports,where very few have studied the mechanical forces that act on the body. There are several factors that contribute to mechanical stress. For preventing injuries, it is of high interest to investigate how these forces affect the body and how the equipment can be further developed to prepare the athletes for making the sport as safe as possible. This project will study injury prevalence, motion analysis and mapping of forces and pressure during kite surfing. The outcome will be a better understanding of biomechanics of kite surfing and a construction for testing and training as well as ergonomic design ideas for the equipment.
38.	Lundgren, Lina, 1982-, et al. (författare) Comfort aspects important for the performance and safety of kitesurfing 2012 Ingår i: Work. - Amsterdam : IOS Press. - 1051-9815 .- 1875-9270. ; 41:Supplement: 1, s. 1221-1225 Tidskriftsartikel (refereegranskat)abstract Equipment used in sports is of great importance, especially when the equipment is in direct contact with the athlete or is important for safety. In the sport kitesurfing environmental factors and the equipment design are crucial for the comfort and safety. The participants' choice and opinion of equipment can show which factors are considered most important for the performance and to reduce risk for injury. This study has evaluated self-reported information from the participants about what equipment they use, comfort of the equipment and if the equipment has contributed to any injuries. The methods used were questionnaires (n-206) and interviews (n-17), which in combination allows to assess the problem both quantitatively and qualitatively. The results showed that supported leading edge kites are most frequently used, with a waist harness and foot straps to attach the feet. The choice of kite type was mainly based on the discipline of riding for the respondent. Some issues concerning comfort of riding and injury risk the respondents did relate to the design of harness and foot straps. The information from this study can be used for development strategies for industry manufacturers and for further studies in the area of equipment design and biomechanics.
39.	Lundgren, Lina, 1982-, et al. (författare) Effect of stance width on kinematics of laboratory landings with fixed feet on a kiteboard 2017 Konferensbidrag (refereegranskat)
40.	Lundgren, Lina, 1982-, et al. (författare) Implementation of usability analysis to detect problems in the management of kitesurfing equipment 2011 Ingår i: Procedia Engineering. - Amsterdam : Elsevier. - 1877-7058. ; 13, s. 525-530 Tidskriftsartikel (refereegranskat)abstract Equipment used for high-risk sports, such as kitesurfing, needs to be efficient for the intended use and the user, and thus meet the mechanical demands and provide sufficient safety. Accidents related to kitesurfing occur, and the consequences are sometimes catastrophic. One important factor is the equipment design, which can influence the type and number of injuries due to insufficient safety systems. The aim of this study was to investigate how the design of kitesurfing equipment can affect safety issues from a usability perspective in relation to the task of preparation. A focus group of 6 subjects analyzed the task of preparing kitesurfing equipment for riding, using the evaluation methods Enhanced Cognitive Walkthrough (ECW) and Predictive Use Error Analysis (PUEA). From the evaluation, a list of plausible usability problems was identified together with proposed design guidelines. The results showed that usability problems occur during preparation. In total 35 usability problems were found, of which 11 (4 from ECW and 7 from PUEA) have a great impact on safety. These 11 problems were hard to detect for the user and could result in serious consequences for the kitesurfers during rideing. The analysis resulted in some general guidelines that are possible to implement on different types of kites. To conclude, education and improved design of the equipment are essential to increase the safety of the sport.
41.	Lundgren, Lina, 1982, et al. (författare) Injuries related to injuries 2011 Ingår i: ICSMSS: VII. International Conference on Sport Medicine and Sport Science. Konferensbidrag (refereegranskat)
42.	Lundgren, Lina, 1982-, et al. (författare) Injuries related to kitesurfing 2011 Ingår i: World Academy of Science, Engineering and Technology. - Istanbul, Turkey : World Academy of Science, Engineering and Technology, WASET. - 2010-3778 .- 2010-376X. ; :77, s. 1132-1136 Tidskriftsartikel (refereegranskat)abstract Participation in sporting activities can lead to injury. Sport injuries have been widely studied in many sports including the more extreme categories of aquatic board sports. Kitesurfing is a relatively new water surface action sport, and has not yet been widely studied in terms of injuries and stress on the body. The aim of this study was to get information about which injuries that are most common among kitesurfing practitioners, where they occur, and their causes. Injuries were studied using an international open web questionnaire (n=206). The results showed that many respondents reported injuries, in total 251 injuries to knee (24%), ankle (17%), trunk (16%) and shoulders (10%), often sustained while doing jumps and tricks (40%). Among the reported injuries were joint injuries (n=101), muscle/tendon damages (n=47), wounds and cuts (n=36) and bone fractures (n=28). Also environmental factors and equipment can influence the risk of injury, or the extent of injury in a hazardous situation. Conclusively, the information from this retrospective study supports earlier studies in terms of prevalence and site of injuries. Suggestively, this information should be used for to build a foundation of knowledge about the sport for development of applications for physical training and product development.
43.	Lundgren, Lena M, et al. (författare) Beskriving av tre klientprofiler inom svensk missbruksvård 2012 Ingår i: Socialvetenskaplig tidskrift. - Umeå : Förbundet för forskning i socialt arbete (FORSA). - 1104-1420 .- 2003-5624. ; 19:3/4, s. 200-216 Tidskriftsartikel (refereegranskat)abstract En klusteranalys av intervjuarskattningar från ASI-intervjuns sju olika livsområden för 12833 klienter visade att klienterna kan delas in i tre olika klientprofiler: Narkotikaprofil, Avgränsade alkoholproblem och Alkohol och psykiska problem. I artikeln jämförs de tre profilerna med avseende på missbruksmönster, demografiska faktorer, sociala och psykiska problem, hälsa och immigrationsstatus.
44.	Lundgren, Lena M., et al. (författare) Mental Health, Substance Use, and Criminal Justice Characteristics of Males With a History of Abuse in a Swedish National Sample 2013 Ingår i: Journal of Dual Dignosis. - : Taylor & Francis Group. - 1550-4263 .- 1550-4271. ; 9:1, s. 47-60 Tidskriftsartikel (refereegranskat)abstract Objective: The primary goals of this study were to (a) provide the first estimate of prevalence of self-reported history of having been emotionally, physically, and/or sexually abused for men with a substance use disorder in Sweden and (b) identify, for men with a substance use disorder, mental health, substance use, and criminal justice characteristics associated with having a history of abuse. Methods: Assessment interviews for a substance use disorder were conducted in 50 out of 300 Swedish counties for the time period 2003 to 2008. Participants were a nationally representative sample of 9,571 Swedish men interviewed in county welfare offices. The Addiction Severity Index (ASI) was used as an assessment tool in these counties. From the ASI, answers to questions asking about lifetime history of emotional, physical, and sexual abuse were analyzed to provide this initial measure on history of abuse. Bivariate statistical analysis and multivariate logistic regression methods were used to explore the relationships between substance use severity, level of mental health problems reported, criminal justice history, and history of being abused. Results: Overall, 47.9% of the men in this sample reported having experienced abuse; specifically, 26.9% of clients reported a history of physical abuse, 4.5% reported a history of sexual abuse, and 40.7% reported a history of emotional abuse. Results from logistic regression modeling identified that higher ASI mental health symptomology scores were associated with 13times higher likelihood of having experienced any abuse. Further, results from logistic regression models identified that scoring higher on the ASI mental health symptoms core was associated with an 8times higher likelihood of having experienced physical abuse,14times higher likelihood of having experienced sexual abuse, and 13times higher likelihood of having experienced emotional abuse. Conclusions: Both the high prevalence of reporting a history of abuse among men with substance use disorders and the strong association between reporting more mental health symptoms and history of abuse indicate a need for Swedish substance use disorder treatment programs to start using more comprehensive and clinically appropriate trauma assessment tools and to provide empirically supported trauma treatments.
45.	Lundgren, Lina, 1982-, et al. (författare) Normalizing stance width 2012 Ingår i: Proceedings of the XIXth Congress of the International Society of Electrophysiology & Kinesiology. - Brisbane : NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health. - 9780646582283 ; , s. 221-221 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract INTRODUCTION: In previous studies, stance widths are most often determined as a percentage of shoulder width, where 70% of shoulder width is considered a narrow stance width and 140% of shoulder width is considered a wide stance width. A few studies have also normalized stance width to the width of the hips (distance between trochanters). However, there are also a possibility to normalize stance width in relation to the length of the lower extremities, since this variable might not change as much in dynamic situations and may correlate higher to the angle of the lower extremity in a frontal plane. AIM: This study aims to compare measurements of stance width when normalized to shoulder width, hip width and leg length for three different stance widths with feet attached to a board. METHOD: Motion capture (Qualisys, 16 Oqus-cameras) was used to measure 7 active male kitesurfers with their feet attached to a kiteboard (136 cm). They were 20-28 years old, in average 180 cm (SD=7 cm) and 78 kg (SD=7 kg). The subjects were standing with three different stance widths, using the same external rotation (20° bilaterally). Markers were attached to shoulders (acromion processes), knee joint lines, hips (trochanter major), heels (mid-posterior of calcaneus) and ankles (lateral and medial malleoli). Stance width was measured as the distance between the two medial ankle markers and normalized towards the distances between (1) the shoulder markers, (2) the hip markers and knee marker plus knee marker and lateral ankle marker and (3) the right and left hip marker. Furthermore, the angle of an extended lower extremity towards a vertical line in the frontal plane was measured. All measurements were done twice, and SPSS 20 was used for data analysis of correlation (Pearson’s r). RESULTS: The measured stance widths between ankles were 39.9 cm, 43.6 cm, and 48 cm (SD=1.2-1.4) for all subjects. The correlations (r) between the angle of the leg towards a vertical line and normalized stance width for the three normalization variables were: (1) 0.79, (2) 0.96 and (3) 0.93. All of the correlations were significant at a level of p>0.01. CONCLUSION: The results show that the variables hip or leg length would be preferred to use when normalizing stance width for young male athletes, standing in wide stance widths. Further studies using a greater number of subjects, more stance widths and a more heterogeneous group are suggested for the future.
46.	Lundgren, Lina, 1982-, et al. (författare) Sport performance and perceived musculoskeletal stress, pain and discomfort in kitesurfing 2011 Ingår i: International Journal of Performance Analysis in Sport. - Abingdon : Taylor & Francis. - 2474-8668 .- 1474-8185. ; 11:1, s. 142-158 Tidskriftsartikel (refereegranskat)abstract The purpose of this study was to obtain an overview of the specific movement patterns in kitesurfing, and the participants' perceptions of musculoskeletal stress, pain and discomfort. Task analysis and survey studies were used to provide an overview of the sport, and to identify problematic issues associated with the performance of the tasks. Three different methods were complimentary used for data collection: observations (n=8), a web questionnaire (n=206) and interviews (n=17). Participants were contacted through kitesurfing events and online forums. Their ages ranged from 16-62 years. The results showed that participants experienced high musculoskeletal stress for short times during a session (jumps, tricks and strong winds), and lower, static musculoskeletal stress over a longer time (crossing). High stress was most frequently perceived in abdominal muscles. Knees and feet were the sites most frequently experienced as painful, followed by the shoulders and elbows. This study provides additional information on the performance of kitesurfing and perceived musculoskeletal stress, pain and discomfort. The results can be used as input data to develop training methods and equipment for safe and comfortable performance. © 2017, Routledge. All rights reserved.
47.	Lundgren, Lina, 1982- (författare) System analysis of kitesurfing : Understanding performance and injury risk for on-water board sports 2011 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract Board sports are examples of sports where the interaction of the task, environment and the athlete are essential. As for other sports, there are injuries and other issues associated with these sports, which affect performance and that can be avoided by proper preparation and well- designed equipment. By focusing on kitesurfing as a system structure the complex interactions between factors can help reveal which variables that are of interest to study to increase the level of performance and safety. Lack of research on the board sport kitesurfing makes this area interesting to study regarding performance and musculoskeletal problems. The purpose of this licentiate thesis was to further the understanding of on-water board sports, and specifically study kitesurfing by using a system analysis to structure factors that influence performance and injury risk for this board sport. The specific aims were:To reveal the most common self-reported injuries related to kitesurfing and their causes (Paper I).To evaluate in which body parts participants perceive musculoskeletal stress, pain and discomfort related to the performance of kitesurfing (Paper II).To identify usability problems related to the preparation of kitesurfing equipment (Paper III).To provide a system analysis to describe the relations between and identify characteristics that influence performance and injury risk of kitesurfing.Methods used for these studies were hierarchical task analysis, observations (n=8), web- questionnaires (n=206), interviews (n=17) and a focus group (n=7). The system analysis was executed in six steps and based on ideas adopted from general systems theory, dynamical systems and ecological task analysis. Tasks performed in freestyle kitesurfing consist of riding a board and performing jumps and tricks, whereof the latter have sub-tasks involving take-off, acrobatic air movements and landings. Within the system of kitesurfing, there are the sub-systems athlete, kite system, board system and harness/protection. There are also external factors acting upon the system. All sub- systems have characteristics that are less changeable during execution of the task and which effect on the athlete can be represented by identified output measures, i.e. harness line force, board reaction force, steering force, pressure distribution, movement patterns, body temperature, fatigue level, comfort and pain, choice of sub-task, mood, stress level, concentration, motivation, experience and usability. The results show that the most frequent locations for injury are in the lower extremities, i.e. knee and ankle, and that about 50% of the injuries reported were associated with jumps and tricks. Equipment and environmental factors also contribute to injuries, as well as to musculoskeletal stress, pain and discomfort. The abdominal muscles were most frequently reported as exposed to high musculoskeletal stress, but also thighs and lower back were perceived as highly stressed throughout the tasks. Knees and feet were areas described as sometimes painful, especially in combination with landings from tricks or strong winds.Furthermore, the lower back was reported painful when kitesurfing in strong winds. When hooking out from the harness for performing tricks, the shoulders were perceived as highly stressed. Before the execution of on-water kitesurfing starts, the preparation of the kite system must be accomplished. The results from Study III showed that there are usability problems related to this kitesurfing task, meaning risk for use error to arise. If use errors occur, serious consequences can follow later in the process. The results emphasize improvement of the products from a usability perspective. Some of the identified output measures were partly answered from the results of Papers I-III, where numbers of injuries, perceived musculoskeletal stress, pain and discomfort, and usability issues were evaluated for kitesurfing. The structure motives the need for further research within the area of on-water board sports and reveals variables that are affecting the system.
48.	Lundgren, Lena, et al. (författare) Using register data to examine patterns of compulsory addiction treatment care in Sweden : program planning and methodological implications 2015 Ingår i: Evaluation and Program Planning. - : Elsevier. - 0149-7189 .- 1873-7870. ; 49, s. 149-152 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
49.	Lundgren, Markus, et al. (författare) Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity 2017 Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 17:1 Tidskriftsartikel (refereegranskat)abstract Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.
50.	Lundgren, Magnus, et al. (författare) Bargaining success in the reform of the Eurozone 2019 Ingår i: European Union Politics. - : SAGE Publications. - 1465-1165 .- 1741-2757. ; 20:1, s. 65-88 Tidskriftsartikel (refereegranskat)abstract This article provides a systematic assessment of bargaining success in the reform of the Eurozone 2010 to 2015. Theoretically, we develop an argument about preferences and institutions as determinants of bargaining success and contrast this argument with an alternative account privileging states’ power resources. Empirically, we conduct a statistical analysis of new data covering all key reform proposals. Our findings are three-fold. First, contrary to a conventional narrative of German dominance, the negotiations produced no clear winners and losers. Second, while power resources were of limited importance, holding preferences that were centrist or close to the European Commission favored bargaining success—particularly when adoption only required the support of a qualified majority. Third, these descriptive and explanatory results reflect dynamics of compromise and reciprocity.

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