| 1. |
- Alm Mårtensson, Anna, et al.
(författare)
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Ansvarsområden för olika samhällsfunktioner
- 2022
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Ingår i: Äldre personers utsatthet för våld i nära relationer. - Lund : Studentlitteratur AB. - 9789144155142 ; , s. 91-112
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Alm Mårtensson, Anna, et al.
(författare)
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Ansvarsområden för olika samhällsfunktioner
- 2022
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Ingår i: Äldre personers utsatthet för våld i nära relationer. - : Studentlitteratur AB. - 9789144155142 ; , s. 91-112
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Frågor om våld i nära relationer är numera vanligt förekommande i media, politiska debatter, offentliga utredningar och lagändringar. Men trots detta uppmärksammas sällan äldre personers utsatthet för våld. Anledningarna kan vara flera, men tanken på att äldre kan utsättas för våld i en nära relation är för många avlägsen.Äldre personers utsatthet för våld i nära relationer vill synliggöra att olika typer av våld förekommer mot och bland äldre personer. Men det allra viktigaste är att ge kunskap om hur omgivningen kan uppmärksamma detta och förhindra våld, samt ge hjälp och stöd. Boken belyser det ansvar som olika myndigheter, såsom socialtjänst, hälso- och sjukvård samt tandvård, har. Ett kapitel beskriver rättsprocessen vid en anmälan och ett annat belyser vilka svårigheter en äldre person kan ha när det gäller att söka hjälp och att bryta upp från en relation. Flera kapitel innehåller konkreta råd för hur exempelvis personal kan ge hjälp och stöd.Äldre personers utsatthet för våld i nära relationer är i första hand skriven för högskoleutbildningar inom socialt arbete, vård, omsorg och medicin. Boken kan också vara till nytta för alla som vill öka sin kunskap om äldre personers utsatthet för våld i nära relationer.
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| 3. |
- Alm Mårtensson, Anna, et al.
(författare)
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Att möta våldsutsatta äldre personer
- 2022
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Ingår i: Äldre personers utsatthet för våld i nära relationer. - Lund : Studentlitteratur AB. - 9789144155142 ; , s. 183-220
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Alm Mårtensson, Anna, et al.
(författare)
-
Att möta våldsutsatta äldre personer
- 2022
-
Ingår i: Äldre personers utsatthet för våld i nära relationer. - : Studentlitteratur AB. - 9789144155142 ; , s. 183-220
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Frågor om våld i nära relationer är numera vanligt förekommande i media, politiska debatter, offentliga utredningar och lagändringar. Men trots detta uppmärksammas sällan äldre personers utsatthet för våld. Anledningarna kan vara flera, men tanken på att äldre kan utsättas för våld i en nära relation är för många avlägsen.Äldre personers utsatthet för våld i nära relationer vill synliggöra att olika typer av våld förekommer mot och bland äldre personer. Men det allra viktigaste är att ge kunskap om hur omgivningen kan uppmärksamma detta och förhindra våld, samt ge hjälp och stöd. Boken belyser det ansvar som olika myndigheter, såsom socialtjänst, hälso- och sjukvård samt tandvård, har. Ett kapitel beskriver rättsprocessen vid en anmälan och ett annat belyser vilka svårigheter en äldre person kan ha när det gäller att söka hjälp och att bryta upp från en relation. Flera kapitel innehåller konkreta råd för hur exempelvis personal kan ge hjälp och stöd.Äldre personers utsatthet för våld i nära relationer är i första hand skriven för högskoleutbildningar inom socialt arbete, vård, omsorg och medicin. Boken kan också vara till nytta för alla som vill öka sin kunskap om äldre personers utsatthet för våld i nära relationer.
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| 5. |
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| 6. |
- Bejerholm, Ulrika, et al.
(författare)
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Rasch Analysis of the Profiles of Occupational Engagement in people with Severe mental illness (POES) instrument
- 2015
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Ingår i: Health and Quality of Life Outcomes. - : Springer Science and Business Media LLC. - 1477-7525. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The Profiles of Occupational Engagement in people with Severe mental illness (POES) instrument was developed to study time use profiles of occupations and measure the extent they are characterized by engagement. However, the dimensional factors are not known. The aim of the present study was to establish the internal construct validity of the POES using the Rasch measurement model. Methods: A sample of 192 outpatients in Sweden was administered the POES and data were subjected to Rasch analysis. Results: The POES showed good fit to the Rasch model after accommodation for local dependency. The nine items had high reliability as measured by person separation index, and no threshold disordering was present. Differential item functioning analysis showed no significant differences across groups of age, sex, diagnosis, or country of origin. Conclusion: The POES is a unidimensional scale that represents a continuum of occupational engagement. The transformed POES sum score can be used on an interval scale to measure status and changes in occupational engagement in mental health practice and research.
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| 7. |
- Björklund, Patrik, et al.
(författare)
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Västerås slott : Slott och borgar
- 2000
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Rapport (populärvet., debatt m.m.)abstract
- En majoritet av dagens byggnadsuppgifter gäller att hantera det redan byggda. När vi står inför situationen att restaurera en befintlig byggnad är det viktigt att förstå olika tidsperioders stilideal liksom byggnadsteknik och material. Först då kan vi göra en väl avvägd analys, som tar tillvara och utvecklar de kvaliteter som byggnaderna själva besitter. Därför är utbildningen upplagd som ett växelspel mellan föreläsningar, seminarier, exkursioner och en för året vald studieuppgift.Slott och borgar har varit läsårets tema. Vi har valt att arbeta med Västerås och Örebro slott - två ganska bortglömda Vasaslott som är väl värda att lyfta fram. Särskilt har vi studerat de senaste 300 årens förändringar, som inte tidigare ägnats lika stora forskarmöda som medelitden och Vasatiden. I dessa två exempel finns en provkarta på estetiska, praktiska och tekniska ingrepp från Carl Hårlemans tid och fram till idag.Studierna har således omfattat både gestaltning, funktion och byggnadsteknik. Avsikten är att visa på kvaliteter i de omvandlingar och restaureringar som skett, men också att peka på problem och analysera olika möjligheter inför framtiden. Arbetet har skett i samarbete med Statens fastighetsverk och är tänkt att utgöra ett underlag till vårdprogram och framtida restaureringsinsatser.
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| 8. |
- Bärring, Maja, 1988, et al.
(författare)
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5G Enabled Manufacturing Evaluation for Data-Driven Decision-Making
- 2018
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Ingår i: Procedia CIRP. - : Elsevier BV. - 2212-8271. ; 27, s. 266-271
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Konferensbidrag (refereegranskat)abstract
- Manufacturing industries are experiencing a technical paradigm shift that will change how they run their operations. Equipment and personnel generate an ever-increasing amount of data, and connectivity enables to utilize data to a larger extent. Connecting a machine is not a technical obstacle anymore, but with all available data, the challenge is to understand the requirements of data to support efficient decision-making. This paper will address the requirements of data by domain experts, in the context of more real-time data available. A focus group interview was performed, assessing the key factors of big data; volume, velocity, and variety of data.
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| 9. |
- Dezfouli, Mahya, et al.
(författare)
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Newborn Screening for Presymptomatic Diagnosis of Complement and Phagocyte Deficiencies
- 2020
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Ingår i: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- The clinical outcomes of primary immunodeficiencies (PIDs) are greatly improved by accurate diagnosis early in life. However, it is not common to consider PIDs before the manifestation of severe clinical symptoms. Including PIDs in the nation-wide newborn screening programs will potentially improve survival and provide better disease management and preventive care in PID patients. This calls for the detection of disease biomarkers in blood and the use of dried blood spot samples, which is a part of routine newborn screening programs worldwide. Here, we developed a newborn screening method based on multiplex protein profiling for parallel diagnosis of 22 innate immunodeficiencies affecting the complement system and respiratory burst function in phagocytosis. The proposed method uses a small fraction of eluted blood from dried blood spots and is applicable for population-scale performance. The diagnosis method is validated through a retrospective screening of immunodeficient patient samples. This diagnostic approach can pave the way for an earlier, more comprehensive and accurate diagnosis of complement and phagocytic disorders, which ultimately lead to a healthy and active life for the PID patients.
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| 10. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 11. |
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| 12. |
- Hellström, Ann, 1959, et al.
(författare)
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Association of Docosahexaenoic Acid and Arachidonic Acid Serum Levels With Retinopathy of Prematurity in Preterm Infants
- 2021
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Ingår i: Jama Network Open. - : American Medical Association (AMA). - 2574-3805. ; 4:10
-
Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Supplementing preterm infants with long-chain polyunsaturated fatty acids (LC-PUFA) has been inconsistent in reducing the severity and incidence of retinopathy of prematurity (ROP). Furthermore, few studies have measured the long-term serum lipid levels after supplementation. OBJECTIVE To assess whether ROP severity is associated with serum levels of LC-PUFA, especially docosahexaenoic acid (DHA) and arachidonic acid (AA), during the first 28 postnatal days. DESIGN, SETTING, AND PARTICIPANTS This cohort study analyzed the Mega Donna Mega study, a randomized clinical trial that provided enteral fatty acid supplementation at 3 neonatal intensive care units in Sweden. Infants included in this cohort study were born at a gestational age of less than 28 weeks between December 20, 2016, and August 6, 2019. MAIN OUTCOMES AND MEASURES Severity of ROP was classified as no ROP, mild or moderate ROP (stage 1-2), or severe ROP (stage 3 and type 1). Serum phospholipid fatty acids were measured through gas chromatography-mass spectrometry. Ordinal logistic regression, with a description of unadjusted odds ratio (OR) as well as gestational age- and birth weight-adjusted ORs and 95% CIs, was used. Areas under the curve were used to calculate mean daily levels of fatty acids during postnatal days 1 to 28. Blood samples were obtained at the postnatal ages of 1, 3, 7, 14, and 28 days. RESULTS A total of 175 infants were included in analysis. Of these infants, 99 were boys (56.6%); the median (IQR) gestational age was 25 weeks 5 days (24 weeks 3 days to 26 weeks 6 days), and the median (IQR) birth weight was 785 (650-945) grams. A higher DHA proportion was seen in infants with no ROP compared with those with mild or moderate ROP or severe ROP (OR per 0.5-molar percentage increase, 0.49 [95% CI, 0.36-0.68]; gestational age- and birth weight-adjusted OR, 0.66 [95% CI, 0.46-0.93]). The corresponding adjusted OR for AA levels per 1-molar percentage increase was 0.83 (95% CI, 0.66-1.05). The association between DHA levels and ROP severity appeared only in infants with sufficient AA levels, suggesting that a mean daily minimum level of 7.8 to 8.3 molar percentage of AA was necessary for a detectable association between DHA level and less severe ROP. CONCLUSIONS AND RELEVANCE This cohort study found that higher mean daily serum levels of DHA during the first 28 postnatal days were associated with less severe ROP even after adjustment for known risk factors, but only in infants with sufficiently high AA levels. Further studies are needed to identify LC-PUFA supplementation strategies that may prevent ROP and other morbidities.
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| 13. |
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| 14. |
- Klevebro, Susanna, et al.
(författare)
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Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care
- 2021
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Ingår i: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 49:7, s. 707-712
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Tidskriftsartikel (refereegranskat)abstract
- We aimed to assess prevalence of IgG antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and factors associated with seropositivity in a large cohort of healthcare workers (HCWs). Methods: From 11 May until 11 June 2020, 3981 HCWs at a large Swedish emergency care hospital provided serum samples and questionnaire data. Presence of IgG antibodies to SARS-CoV-2 was measured as an indicator of SARS-CoV-2 exposure. Results: The total seroprevalence was 18% and increased during the study period. Among the seropositive HCWs, 11% had been entirely asymptomatic. Participants who worked with COVID-19 patients had higher odds for seropositivity: adjusted odds ratio 1.96 (95% confidence intervals 1.59–2.42). HCWs from three of the departments managing COVID-19 patients had significantly higher seroprevalences, whereas the prevalence among HCWs from the intensive care unit (also managing COVID-19 patients) was significantly lower. Conclusions: HCWs in contact with SARS-CoV-2 infected patients had a variable, but on average higher, likelihood for SARS-CoV-2 infections.
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| 15. |
- Leimalm, Ulrika, et al.
(författare)
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Off-gas dust in an experimental blast furnace part 1: Characterization of flue dust, sludge and shaft fines
- 2010
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Ingår i: ISIJ International. - : Iron and Steel Institute of Japan. - 0915-1559 .- 1347-5460. ; 50:11, s. 1560-1569
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Tidskriftsartikel (refereegranskat)abstract
- In blast furnace (BF) ironmaking, efforts are made to decrease coke consumption, which can be done by increasing the pulverized coal injection rate (PCR). This will cause changes in ¡n-furnace reduction conditions, burden distribution, demands on raw material strength, etc. In order to maintain stable operation, but also to obtain low amounts of material losses through the off-gas, it is important to understand fines generation and behaviour in the BF Off-gas dust and shaft fines generated in the LKAB Experimental Blast Furnace (EBF) were sampled during operation with olivine pellets and mixtures of acid pellets and sinter as iron-bearing materials. Characterization using XRD, SEM and LOM was focused on fines from iron-bearing materials, coke and slag formers. The results showed that flue dust, mainly <0.5 mm, was mechanically formed and created in the same manner for all investigated samples. Carbon-containing particles dominated in the fractions >0.075 mm and consisted mainly of coke particles from the shaft. Fe-containing particles, as Fe2O 3 from the top of the shaft, formed the major part of flue dust fractions <0.063 mm. Particles from slag formers such as quartzite and limestone were observed in flue dust when slag formers were utilized in the feed. Sludge consisted mainly of chemically formed spherical particles <1 μm precipitated from the ascending gas as the temperature decreased. © 2010 ISIJ.
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| 16. |
- Llona-Minguez, Sabin, et al.
(författare)
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Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
- 2017
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 60:5, s. 2148-2154
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Tidskriftsartikel (refereegranskat)abstract
- The dCTP pyrophosphatase 1 (dCTPase) is involved in the regulation of the cellular dNTP pool and has been linked to cancer progression. Here we report on the discovery of a series of 3,6-disubstituted triazolothiadiazoles as potent dCTPase inhibitors. Compounds 16 and 18 display good correlation between enzymatic inhibition and target engagement, together with efficacy in a cellular synergy model, deeming them as a promising starting point for hit -to-lead development.
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| 17. |
- Lundgren, Camilla, 1989, et al.
(författare)
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Challenges Building a Data Value Chain to Enable Data-Driven Decisions: A Predictive Maintenance Case in 5G-Enabled Manufacturing
- 2018
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Ingår i: Procedia Manufacturing. - : Elsevier BV. - 2351-9789. ; 17, s. 411-418
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Konferensbidrag (refereegranskat)abstract
- Improvements in data storage and processing technologies have led many managers to change how they make decisions, relying less on intuition and more on data. This trend is especially notable for the manufacturing industry where Big Data applications, i.e. data analytics, are mentioned as an important enabler of value creation with the event of the fourth industrial revolution. Designing and building the entire data value chain that enables Big Data applications in manufacturing requires new knowledge about digital technologies combined with already established knowledge about the specific manufacturing processes. This paper focuses on the convergence of these different knowledge spaces applied to a specific case of implementing a Big Data application for predictive maintenance. Every step of building the data value chain from data acquisition to system feedback is presented and discussed in terms of the major challenges that were observed during the project. Results show that, just as the literature suggests, the knowledge gaps between different domains is a key component to manage for succeeding when building Big Data applications in the context of future manufacturing and maintenance.
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| 18. |
- Lundgren, Dan, et al.
(författare)
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Changes in perceived psychosocial work environment in old age carefrom 2007 to 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This study examines changes in nursing assistants’ perceived psychosocial work environment 2007-2015 and whether there are differences between nursing homes and home care. Repeated cross-sectional surveys were conducted (summed sample N = 9400) in nursing homes and home care units. Mixed linear models with random intercept, slope and variance were used. Nursing assistants in nursing homes assess their psychosocial work environment better than nursing assistants in home care do. When analysing linear trends for the entire time period (2007-2015), we found a decline in control at work (p < .001) in both nursing homes and home care and positive trends for stimulus from work itself (nursing homes, p < .001 and home care, p = .004). This indicates that nursing assistants perceived decreasing control of their work situation and increasing stimulus from work itself over the period 2007-2015. The results indicated shifting trends when the municipality introduced different reforms, such as the act of a system of choice in the public sector and the implementation of home health care. These findings suggest that it is important for old-age care organisations to consider long-term consequences for nursing assistants’ psychosocial work environment when implementing new reforms and organizational changes.
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| 19. |
- Lundgren, Dan
(författare)
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Leadership, psychosocial work environment, and satisfaction with elder care among care recipients : Analysing their associations and the structural differences between nursing homes and home care
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundMunicipal elder care has become increasingly multifaceted, and the quest for quality is a continuing discussion in Swedish elder care. In recent decades, municipalities have prioritized older adults with severe needs. There is also a trend of more elderly individuals receiving care in their own homes. The number of persons 80 years and older will increase by approximately 75 percent between 2015 and 2035. During the same period, the numbers of nursing assistants are likely to decrease. Furthermore, health and social care services have the highest rates of sick leave in Sweden, and the psychosocial work environment plays an important role in reducing sick leave. Perceived support from an organization, leaders and colleagues has been shown to have a positive effect on nursing assistants’ perceptions of the psychosocial work environment in elder care settings. Leadership characteristics or attributes and behaviours have been associated with a healthy work environment. Thus, knowledge regarding the associations between leadership, the psychosocial work environment, and recipient satisfaction in elder care is insufficient.AimsThe overall aim of this thesis was to explore and describe the associations between leadership, the psychosocial work environment, and recipient satisfaction in municipal elder care, the changes over time in psychosocial work environment, and the difference between nursing homes and home care.Design and methodsThis thesis is based on four cross-sectional studies (I-IV) and one study based on repeated cross-sectional analyses (V). Data from three different surveys were used: the Developmental Leadership Questionnaire (DLQ), the Questionnaire for Psychological and Social Factors at Work (QPS), and a recipient satisfaction survey (based on a National Board of Health and Welfare recipient satisfaction survey). Study I analyses first-line managers’ assessments of their leadership and nursing assistants’ assessments of their first-line managers. Study II analyses the associations between leadership and the psychosocial work environment, study III the associations between psychosocial work environment and recipient satisfaction, and study IV encompasses all three levels, leadership and the psychosocial work environment, and recipient satisfaction. Study V describes changes in the psychosocial work environment between 2007 and 2015.Results There are structural differences between nursing homes and home care in the assessments of leadership, the psychosocial work environment, and satisfaction among older people. Linear trends for the period 2007-2015 demonstrate a decline in control at work in both nursing homes and home care and positive trends for stimulus from the work itself. The results also show that nursing assistants in nursing homes rate their psychosocial work environment higher than nursing assistants in home care. Older adults receiving home care report higher satisfaction than those receiving care in nursing homes. In contrast, nursing assistants in home care rate their first-line managers’ leadership and their perceived psychosocial work environment lower than those working in nursing homes. Process-related factors, for example, the association between leadership and the psychosocial work environment, showed that interpersonal factors, such as support from superiors, empowering leadership, human resource primacy, and direct leadership, may impact nursing assistants’ psychosocial work environment in both nursing homes and home care. A better psychosocial work environment among nursing assistants was associated with higher satisfaction among recipients of elder care, except for the recipient satisfaction item staff knowledge, which had negative associations with the psychosocial work environment.Conclusions and implications for practiceTo influence nursing assistants’ performance, to increase recipient satisfaction and to increase quality in eldercare in the long term, appropriate leadership and a healthy psychosocial work environment are necessary. To make the most out of the available resources and to meet future challenges (among others) in elder care require organizational attention so that leadership and psychosocial work environments continue to develop in both nursing homes and home care. Therefore, structural differences in elder care must be considered to create a better psychosocial work environment for nursing assistants and, in turn, to create higher care satisfaction for those who are receiving elder care in two different social contexts.
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| 20. |
- Lundgren, Dan, et al.
(författare)
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The Association Between Psychosocial Work Environment and Satisfaction With Old Age Care Among Care Recipients
- 2020
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Ingår i: Journal of Applied Gerontology. - : SAGE Publications. - 0733-4648 .- 1552-4523. ; 39:7, s. 785-794
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the association between nursing assistants' perceptions of their psychosocial work environment and satisfaction among older people receiving care in nursing homes and home care. Cross-sectional surveys were conducted among people receiving care (N= 1,535) and nursing assistants (N= 1,132) in 45 nursing homes and 21 home care units within municipal old-age care. Better psychosocial work environment was related to higher satisfaction in old-age care among the recipients. Significant and stronger associations were more common in nursing homes than in home care. Perception of mastery and positive challenges at work were associated with higher recipient satisfaction both in home care and in nursing homes: social climate, perception of group work, perception of mastery, and positive challenges at work only in nursing homes. Findings suggest that recipient satisfaction may be increased by improving the psychosocial work environment for nursing assistants, both in nursing homes and in home care.
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| 21. |
- Lundgren, Dan, et al.
(författare)
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The Impact of Leadership and Psychosocial Work Environment on Recipient Satisfaction in Nursing Homes and Home Care
- 2019
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Ingår i: Gerontology and geriatric medicine. - : SAGE Publications. - 2333-7214. ; 5, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the association between nursing assistants' assessment of leadership, their psychosocial work environment, and satisfaction among older people receiving care in nursing homes and home care. Cross-sectional surveys were conducted with nursing assistants (n = 1,132) and people receiving care (n = 1,535) in 45 nursing homes and 21 home care units. Direct leadership was associated with the psychosocial work environment in nursing homes and home care. Furthermore, better leadership was related to higher satisfaction among nursing assistants and older people in nursing homes. Thus, indirect leadership had no effect on recipients' satisfaction in either nursing homes or home care. The path analysis showed an indirect effect between leadership factors and recipient satisfaction. The findings suggest that the psychosocial work environment of nursing assistants and recipient satisfaction in nursing homes can be increased by improving leadership.
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| 22. |
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| 23. |
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| 24. |
- Lundgren, Maria, et al.
(författare)
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Off-gas dust in an experimental blast furnace part 2: Relation to furnace conditions
- 2010
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Ingår i: ISIJ International. - : Iron and Steel Institute of Japan. - 0915-1559 .- 1347-5460. ; 50:11, s. 1570-1580
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Tidskriftsartikel (refereegranskat)abstract
- In the blast furnace process, material losses are caused by particles that are blown out of the furnace by the off-gas. In order to reduce these losses, it is important to understand the correlations between furnace conditions and off-gas dust formation. Off-gas dust, as flue dust and sludge, were collected during shaft probe sampling in LKAB Experimental Blast Furnace (EBF). Process data was used to evaluate the relationship between off-gas dust amounts and furnace conditions. The graphitization degree (Lc value) of shaft coke and coke in flue dust was determined using XRD measurements. Solution loss in the shaft had a negligible effect on coke degradation and the coke particles which ended up in the flue dust were mainly derived from abrasion at low temperatures. The amount of alkali and SiO2 in sludge increased with higher PCR and flame temperature, which confirmed that submicron spherical particles in sludge originated from the high temperature area around the raceway. Theoretical critical particle diameters of materials, which could be blown out with the off-gas, were estimated. Flow conditions in the top of the shaft as well as and the properties of fine particles in terms of size and density are important when outflow of mechanical dust, such as flue dust, is concerned. Low off-gas temperatures, and thus lower off-gas velocities, are favourable for low flue dust amounts expelled from the blast furnace. © 2010 ISIJ.
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| 25. |
- Mesfun, Sennai, et al.
(författare)
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Black liquor fractionation for biofuels production : A techno-economic assessment
- 2014
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Ingår i: Bioresource Technology. - : Elsevier BV. - 0960-8524 .- 1873-2976. ; 166, s. 508-517
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Tidskriftsartikel (refereegranskat)abstract
- The hemicelluloses fraction of black liquor is an underutilized resource in many chemical pulp mills. It is possible to extract and separate the lignin and hemicelluloses from the black liquor and use the hemicelluloses for biochemical conversion into biofuels and chemicals. Precipitation of the lignin from the black liquor would consequently decrease the thermal load on the recovery boiler, which is often referred to as a bottleneck for increased pulp production. The objective of this work is to techno-economically evaluate the production of sodium-free lignin as a solid fuel and butanol to be used as fossil gasoline replacement by fractionating black liquor. The hydrolysis and fermentation processes are modeled in Aspen Plus to analyze energy and material balances as well as to evaluate the plant economics. A mathematical model of an existing pulp and paper mill is used to analyze the effects on the energy performance of the mill subprocesses.
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| 26. |
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| 27. |
- Micke, Patrick, et al.
(författare)
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The prognostic impact of the tumour stroma fraction : A machine learning-based analysis in 16 human solid tumour types
- 2021
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 65
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Tidskriftsartikel (refereegranskat)abstract
- Background: The development of a reactive tumour stroma is a hallmark of tumour progression and pronounced tumour stroma is generally considered to be associated with clinical aggressiveness. The variability between tumour types regarding stroma fraction, and its prognosis associations, have not been systematically analysed.Methods: Using an objective machine-learning method we quantified the tumour stroma in 16 solid cancer types from 2732 patients, representing retrospective tissue collections of surgically resected primary tumours. Image analysis performed tissue segmentation into stromal and epithelial compartment based on pan-cytokeratin staining and autofluorescence patterns.Findings: The stroma fraction was highly variable within and across the tumour types, with kidney cancer showing the lowest and pancreato-biliary type periampullary cancer showing the highest stroma proportion (median 19% and 73% respectively). Adjusted Cox regression models revealed both positive (pancreato-biliary type periampullary cancer and oestrogen negative breast cancer, HR(95%CI)=0.56(0.34-0.92) and HR (95%CI)=0.41(0.17-0.98) respectively) and negative (intestinal type periampullary cancer, HR(95%CI)=3.59 (1.49-8.62)) associations of the tumour stroma fraction with survival.Interpretation: Our study provides an objective quantification of the tumour stroma fraction across major types of solid cancer. Findings strongly argue against the commonly promoted view of a general associations between high stroma abundance and poor prognosis. The results also suggest that full exploitation of the prognostic potential of tumour stroma requires analyses that go beyond determination of stroma abundance.
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| 28. |
- Nettelbladt, Ulrika, et al.
(författare)
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Barn med språkliga svårigheter
- 2017. - 1
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Ingår i: Barnneurologi. - 9789144078885 ; , s. 615-617
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Bokkapitel (refereegranskat)
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| 29. |
- Nilsson, Anders K., 1982, et al.
(författare)
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Sphingolipidomics of serum in extremely preterm infants : Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
- 2021
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Ingår i: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. - : Elsevier. - 1388-1981 .- 1879-2618. ; 1866:7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP) that can cause impaired vision or blindness. Changes in blood lipids have been associated with ROP. This study aimed to monitor longitudinal changes in the serum sphingolipidome of extremely preterm infants and investigate the relationship to severe ROP development.METHODS: This is a prospective study that included 47 infants born <28 gestational weeks. Serum samples were collected from cord blood and at postnatal days 1, 7, 14, and 28, and at postmenstrual weeks (PMW) 32, 36, and 40. Serum sphingolipids and phosphatidylcholines were extracted and analyzed by LC-MS/MS. Associations between sphingolipid species and ROP were assessed using mixed models for repeated measures.RESULTS: The serum concentration of all investigated lipid classes, including ceramide, mono- di- and trihexosylceramide, sphingomyelin, and phosphatidylcholine displayed distinct temporal patterns between birth and PMW40. There were also substantial changes in the lipid species composition within each class. Among the analyzed sphingolipid species, sphingosine-1-phosphate showed the strongest association with severe ROP, and this association was independent of gestational age at birth and weight standard deviation score change.CONCLUSIONS: The serum phospho- and sphingolipidome undergoes significant remodeling during the first weeks of the preterm infant's life. Low postnatal levels of the signaling lipid sphingosine-1-phosphate are associated with the development of severe ROP.
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| 30. |
- Nilsson, Robert, et al.
(författare)
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Techno-economics of carbon preserving butanol production using a combined fermentative and catalytic approach
- 2014
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Ingår i: Bioresource Technology. - : Elsevier BV. - 0960-8524 .- 1873-2976. ; 161, s. 263-269
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a novel process for n-butanol production which combines a fermentation consuming carbon dioxide (succinic acid fermentation) with subsequent catalytic reduction steps to add hydrogen to form butanol. Process simulations in Aspen Plus have been the basis for the techno-economic analyses performed. The overall economy for the novel process cannot be justified, as production of succinic acid by fermentation is too costly. Though, succinic acid price is expected to drop drastically in a near future. By fully integrating the succinic acid fermentation with the catalytic conversion the need for costly recovery operations could be reduced. The hybrid process would need 22% less raw material than the butanol fermentation at a succinic acid fermentation yield of 0.7 g/g substrate. Additionally, a carbon dioxide fixation of up to 13 ktonnes could be achieved at a plant with an annual butanol production of 10 ktonnes
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| 31. |
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| 32. |
- Olofsson, Roger, 1978, et al.
(författare)
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Isolated hepatic perfusion as a treatment for uveal melanoma liver metastases (the SCANDIUM trial) : study protocol for a randomized controlled trial
- 2014
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Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 15, s. 317-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the primary tumor, metastatic disease will ultimately develop in approximately 50% of patients, with the liver being the most common site for metastases. The median survival for patients with liver metastases is between 6 and 12 months, and no treatment has in randomized trials ever been shown to prolong survival. A previous phase II trial using isolated hepatic perfusion (IHP) has suggested a 14-month increase in overall survival compared with a historic control group consisting of the longest surviving patients in Sweden during the same time period (26 versus 12 months). Methods/Design: This is the protocol for a multicenter phase III trial randomizing patients with isolated liver metastases of uveal melanoma to IHP or best alternative care (BAC). Inclusion criteria include liver metastases (verified by biopsy) and no evidence of extra-hepatic tumor manifestations by positron emission tomography-computed tomography (PET-CT). The primary endpoint is overall survival at 24 months, with secondary endpoints including response rate, progression-free survival, and quality of life. The planned sample size is 78 patients throughout five years. Discussion: Patients with isolated liver metastases of uveal melanoma origin have a short expected survival and no standard treatment option exists. This is the first randomized clinical trial to evaluate IHP as a treatment option with overall survival being the primary endpoint.
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| 33. |
- Smedberg, Carl-Filip, 1992-
(författare)
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Klassriket : Socialgruppsindelningen som skillnadsteknologi under 1900-talet
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- During the 20th century, a number of actors and institutions set out to develop taxonomies of the Swedish population. This thesis examines the most important social classification system, the social group, which despite its great importance in administrative, scientific, commercial, political and media contexts has received little attention in historical research. Invented by the Central Bureau of Statistics in 1911 to map voters according to their social position, the division enabled Swedes to be hierarchized under the categories of social group I, II or III. The taxonomy became a standard for a number of knowledge-producing institutions in their studies of the Swedish class structure: for the nascent market research companies and their assessments of consumers from the 1930s onwards; for the polling companies’ surveys of public opinion from the 1940s onwards; and for the post-war social science research and government committees’ statistical production about higher education.The thesis analyses classification systems in use and in movement between actors and contexts. Social taxonomies are understood as difference technologies: by which I mean ways of mapping and studying populations. They link populations together, quantify concepts into precise classifications and enable specific overviews of social structures – knowledge that can then be used as a basis for action and societal interventions. Moreover, the social group division was widely discussed in post-war Swedish press and mediated into images and tables. Actors within media interpreted and used it differently, and as a result, new meaning was created around it. The division was presented by some as cultural communities, while others pointed to it as evidence of a new social phase, characterised by declining class conflicts. Finally, it became the focus for meta-reflections on the societal place and impact of social divisions. Through these mediated engagements, the taxonomy became a given yet contested part of the Swedish public sphere.
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| 34. |
- Tegner, Cecilia, et al.
(författare)
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Alpha-chloralose poisoning in cats : clinical findings in 25 confirmed and 78 suspected cases
- 2022
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Ingår i: Journal of feline medicine and surgery. - : SAGE Publications. - 1098-612X .- 1532-2750. ; 24:10, s. E324-E329
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Tidskriftsartikel (refereegranskat)abstract
- Objectives The aim of this study was to describe the clinical picture in cats with alpha-chloralose (AC) intoxication and to confirm AC in serum from suspected cases of AC poisoning. Methods Suspected cases of AC poisoning were identified in patient records from a small animal university hospital from January 2014 to February 2020. Clinical signs of intoxication described in respective records were compiled, the cats were graded into four intoxication severity scores and hospitalisation time and mortality were recorded. Surplus serum from select cases in late 2019 and early 2020 was analysed to detect AC with a quantitative ultra-high performance liquid chromatography tandem mass spectrometry analysis, and the AC concentration was compared with the respective cat's intoxication severity score. Results Serum from 25 cats was available for analysis and AC poisoning was confirmed in all. Additionally, 78 cats with a clinical suspicion of AC intoxication were identified in the patient records, most of which presented from September to April. The most common signs of intoxication were ataxia, tremors, cranial nerve deficits and hyperaesthesia. The prevalence of clinical signs and intoxication severity differed from what has previously been reported, with our population presenting with less severe signs and no deaths due to intoxication. The majority had a hospitalisation time <48 h, irrespective of intoxication severity score. Conclusions and relevance This study describes the clinical signs and prognosis in feline AC intoxication. There were no mortalities in confirmed cases, indicating that AC-poisoned cats have an excellent prognosis when treated in a timely manner. Recognition of AC intoxication as a differential diagnosis for acute onset of the described neurological signs in areas where AC exposure is possible may influence clinical decision-making and help avoid excessive diagnostic procedures. A severe clinical picture upon presentation could be misinterpreted as a grave prognosis and awareness about AC poisoning may avoid unnecessary euthanasia.
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| 35. |
- Warne, Maria, 1957-, et al.
(författare)
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Supported Education som pedagogiskt stöd när studenters psykiska ohälsa ökar
- 2024
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Konferensbidrag (refereegranskat)abstract
- Bakgrund: Psykisk ohälsa är den vanligaste formen av funktionsnedsättning eller ohälsa bland studenter (UHR, 2018). Mellan 2022 och 2023 har andelen kvinnor i åldern 16–29 år som upplever stress ökat från redan höga nivåer, medan den sjunkit för män (FHM, 2023). I denna ålder studerar många. Psykisk ohälsa kan leda till ökade problem att genomföra studierna, fortsatt psykisk ohälsa och långvarig marginalisering kopplat till oförmåga att etablera sig som självständig vuxen (Patel et al., 2007). Universitet och högskolor ska enligt högskolelagen och dess förordningar skapa likvärdiga villkor och arbeta i linje med krav på breddad rekrytering. Tidigare studier har visat att studenter som får stöd under sin studietid har förutsättningar att fullfölja studierna, men att det behövs flera olika insatser (Kim, Kathy & Anthony, 2010). Supported Education (SEd) är en metod som avser att stötta studenter med psykisk ohälsa att söka, erhålla och genomföra studier utifrån egna preferenser (Hofstra & Korevaar, 2016). Effektstudier pågår (Hofstra et al., 2021). Metoden har ursprungligen utvecklats för personer med allvarlig psykisksjukdom men har under senare tid avänts både preventivt och promotivt. Stödet ges ovillkorat till studenter som upplever problem att välja, skaffa och behålla utbildning. Mellan 2020 och 2023 har Supported Education prövats vid Mittuniversitetet med fokus på att behålla utbildning. Sedan hösten 2023 är metoden en permanent verksamhet vid universitetet.Syftet: Att presentera metoden Supported Education, vägen från projekt till permanent SEd-verksamhetvid Mittuniversitetet samt studenters syn på detta stöd.Metod: Data utgjordes av enkäter, minnesanteckningar, workshops och intervjuer. Deltagare var studenter och universitetspersonal. En kvalitativ analys genomfördes av utgångsläge, process och upplevelser.Resultat: Studenter som erhållit stöd via Supported Education upplever bättre struktur, ökad insikt om hinder, behov och resurser samt ökad känsla av sammanhang och trygghet i att stöd finns att få. Bred förankring, där representanter från fakulteterna, studenthälsan, studentkårerna och förvaltningen ingick, gav ett universitetsövergripande stöd för metoden. Verksamhetens placering i organisationen upplevdes som en utmanande process. SEd går emot gängse praxis om pedagogiskt stöd till studenter med funktionsnedsättning genom att ges utan krav på diagnosticering till dem som erfar stödbehov utifrån sin studiesituation. Detta upplevs positivt av både studenter och personal. SEd är en kostnadseffektiv metod som bidrar till att öka tillgängligheten till studier för fler och möjlighet att både fullfölja studier och må rimligt bra under tiden.
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| 36. |
- Windahl, Ulrika, et al.
(författare)
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Alpha-chloralose poisoning in cats in three Nordic countries-the importance of secondary poisoning
- 2022
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Ingår i: BMC Veterinary Research. - : Springer Nature. - 1746-6148. ; 18:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Alpha-chloralose (AC) is a compound known to be toxic to various animal species and humans. In 2018 and 2019 an increase in suspected cases of AC poisoning in cats related to the use of AC as a rodenticide was reported to national veterinary and chemical authorities in Finland, Norway and Sweden by veterinarians working in clinical practices in respective country. The aims of this study were to prospectively investigate AC poisoning in cats, including possible secondary poisoning by consuming poisoned mice, and to study metabolism and excretion of AC in cats through analysis of feline urine. Methods Data on signalment, history and clinical findings were prospectively collected in Finland, Norway and Sweden from July 2020 until March of 2021 using a questionnaire which the attending veterinarian completed and submitted together with a serum sample collected from suspected feline cases of AC-poisoning. The diagnosis was confirmed by quantification of AC in serum samples. Content of AC was studied in four feline urine samples, including screening for AC metabolites by UHPLC-HRMS/MS. Bait intake and amount of AC consumed by mice was observed in wild mice during an extermination of a rodent infestation. Results In total, 59 of 70 collected questionnaires and accompanying serum samples were included, with 127 to 70 100 ng/mL AC detected in the serum. Several tentative AC-metabolites were detected in the analysed feline urine samples, including dechlorinated and oxidated AC, several sulfate conjugates, and one glucuronic acid conjugate of AC. The calculated amount of AC ingested by each mouse was 33 to 106 mg with a mean of 61 mg. Conclusions Clinical recognition of symptoms of AC poisoning in otherwise healthy cats roaming free outdoors and known to be rodent hunters strongly correlated with confirmation of the diagnosis through toxicological analyses of serum samples. The collected feline exposure data regarding AC show together with the calculation of the intake of bait and subsequent AC concentrations in mice that secondary poisoning from ingestion of mice is possible. The results of the screening for AC metabolites in feline urine confirm that cats excrete AC both unchanged and metabolized through dechlorination, oxidation, glucuronidation and sulfatation pathways.
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| 37. |
- Windahl, Ulrika, et al.
(författare)
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Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning
- 2022
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Ingår i: Journal of Analytical Toxicology. - : Oxford University Press. - 0146-4760 .- 1945-2403. ; 46:6, s. 651-657
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Tidskriftsartikel (refereegranskat)abstract
- Alpha-chloralose (AC) is used as a rodenticide as well as an anesthetic agent in laboratory animals. It was previously also used as an avicide. Detection of AC in blood samples or in body tissues collected postmortem is key for the diagnosis of clinical cases and a requirement for surveillance of secondary toxicosis, including potential cases in wild animals. Reports on poisoning of humans and non-laboratory animals confirmed by the detection of AC or its metabolites are available, however poisoning of domestic animals are rarely available. Furthermore, reports on clinical cases in domestic animals rarely report quantifications of AC in blood or body tissues. The present study describes the validation of a quantitative Ultrahigh Performance Liquid Chromatography tandem Mass Spectrometry (UHPLC-MS-MS) method that can be used in cases of suspected AC poisoning in cats. The validation study showed the method to be fit for purpose. In serum, the limit of quantification was 100 ng/mL and the limit of detection was 30 ng/mL. The new analytical method was applied on blood samples collected from 20 individual cats with a preliminary clinical diagnosis of acute AC poisoning. AC was confirmed in all 20 feline blood samples, and the concentration range of AC was 538-17,500 ng/mL. The quantitative method developed in this study was found to be a fast and selective method for confirmation of AC poisoning using blood samples from cats.
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| 38. |
- Åkerman, Magnus, 1978, et al.
(författare)
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Technical Interoperability for Machine Connectivity on the Shop Floor
- 2018
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Ingår i: Technologies. - : MDPI AG. - 2227-7080. ; 6:3
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a generic technical solution that can increase Industry 4.0 maturity by collecting data from sensors and control systems on the shop floor. Within the research project “5G-Enabled Manufacturing”, an LTE (Long-Term Evolution) network with 5G technologies was deployed on the shop floor to enable fast and scalable connectivity. This network was used to connect a grinding machine to a remote private cloud where data was stored and streamed to a data analytics center. This enabled visibility and transparency of the production data, which is the basis for Industry 4.0 and smart manufacturing. The solution is described with a focus on high-level communication technologies above wireless communication standards. These technologies are discussed regarding technical interoperability, focusing on the system layout, communication standards, and open systems. From the discussion, it can be derived that generic solutions such as this are possible, but manufacturing end-users must expand and further internalize knowledge of future information and communication technologies to reduce their dependency on equipment and technology providers.
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