| 1. |
- Lindgren, Moa, et al.
(författare)
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Type IV Collagen in Human Colorectal Liver Metastases—Cellular Origin and a Circulating Biomarker
- 2022
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:14
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Tidskriftsartikel (refereegranskat)abstract
- Circulating type IV collagen (cCOL IV) is a potential biomarker for patients with colorectal liver metastases (CLM) who present with elevated levels of COL IV in both CLM tissue and circulation. This study aimed to establish the cellular origin of elevated levels of COL IV and analyze circulating COL IV in CLM patients. The cellular source was established through in situ hybridization, immunohistochemical staining, and morphological evaluation. Cellular expression in vitro was assessed by immunofluorescence. Tissue expression of COL IV-degrading matrix metalloproteinases (MMPs)-2, -7, -9, and -13 was studied with immunohistochemical staining. Plasma levels of COL IV in CLM patients and healthy controls were analyzed with ELISA. This study shows that cancer-associated fibroblasts (CAFs) express COL IV in the stroma of CLM and that COL IV is expressed in vitro by fibroblasts but not by tumor cells. MMP-2, -7, -9, and -13 are expressed in CLM tissue, mainly by hepatocytes and immune cells, and circulating COL IV is significantly elevated in CLM patients compared with healthy controls. Our study shows that stromal cells, not tumor cells, produce COL IV in CLM, and that circulating COL IV is elevated in patients with CLM.
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| 2. |
- Lindhe, Nike, et al.
(författare)
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Tailored internet-delivered cognitive behavioral therapy for individuals experiencing psychological distress associated with climate change: A pilot randomized controlled trial
- 2023
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Ingår i: Behaviour Research and Therapy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0005-7967 .- 1873-622X. ; 171
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Tidskriftsartikel (refereegranskat)abstract
- Even among people who are not directly impacted by the consequences of climate change, perceptions about the ongoing crisis can have a negative effect on mental health and well-being. However, empirical evidence on interventions aiming to provide support is currently scarce. In order to address this issue, a pilot-RCT was carried out to investigate the effects of a novel ICBT treatment program. Sixty participants (23-73 years) were recruited and randomly allocated to eight weeks of therapist-supported ICBT (n = 30) or a wait-list control condition (n = 30). Measures of depressive symptoms, stress, and quality of life were used as primary outcomes, while measures of anxiety, insomnia, climate change-related distress, pro-environmental behaviour, and alcohol use were used as secondary outcomes. The treatment group had moderate to large between-group effects compared to the waitlist group on measures of depression (d = 0.87), stress (d = 0.76), quality of life (d = 0.79) and climate change-related distress (d = 0.79). There were no significant between-group differences on the other outcome measures. The results from this pilot-RCT indicate that individually tailored ICBT can be an effective way to reduce psychological distress associated with climate change without reducing pro-environmental behaviour.
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| 3. |
- Lundin, Elin, 1976-, et al.
(författare)
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Experiences of rehabilitation services from the perspective of older adults with dual sensory loss : a qualitative study
- 2022
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Ingår i: International Journal of Qualitative Research on Health and Well-being.. - : Taylor & Francis. - 1748-2623 .- 1748-2631. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To describe the rehabilitation service experiences of older adults with dual sensoryloss (DSL).Methods: Twenty older adults aged ≥65 years with DSL participated in semistructuredinterviews. Inductive qualitative content analysis was conducted.Results: The participants’ experiences were classified into three main categories: 1.Maintaining and regaining function included experiences regarding interventions compensat-ing for loss of function and medical corrections; 2. Mastering the situation described theindividuals’ competence of DSL, skills acquisition and taking control; and 3. Delivery ofrehabilitation services included experiences of encounters with professionals, their attitudesand the organizational impact on accessibility and collaboration.Conclusions: It was important for participants to regain function and compensate for loss infunction and to meet others in group rehabilitation. The professionals’ attitudes were animportant factor that affected the participants’ approach to rehabilitation services.Rehabilitation services mainly focused on either VL or HL, not DSL. Based on the participants’experiences, the rehabilitation services seemed to contribute to the older adults’ well-being,participation in activities and life roles, which is consistent with the WHO’s definition ofhealthy ageing. The findings can contribute to the development of rehabilitation services forolder adults with DSL to meet the diversity of these individuals’ needs.
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| 4. |
- Lundin, Elin, 1976-
(författare)
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Older Adults with Dual Sensory Loss : Prevalence, Diagnoses & Rehabilitation Services
- 2022
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: Globally, the population aged 65 years and older are predicted to double within 30 years. The risk of developing vision loss in combination with hearing loss – dual sensory loss (DSL) increases with age. DSL affects older adults within several aspects, and the main areas are communication, information, participation and orientation and mobility. Aim: The overall aim was to describe older adults with DSL regardingprevalence, diagnoses, rehabilitation and experiences with rehabilitation services in the Swedish context.Methods: Quantitative and qualitative methods were used. Data were collected by using register data, mainly medical records (Study I), and by individual interviews with older adults with DSL (Study II). In the first study, data were analysed using descriptive statistics and chi square tests, and in the second study inductive qualitative content analysis was used. Results: Study I showed that the national prevalence of severe DSL was estimated to approximately 0.08%. The result also showed statisticallysignificant differences in prevalence of severe DSL between age groups and the prevalence of severe DSL increased with age. No statistically significant difference were found between women and men regarding prevalence. Older adults with DSL had been provided with several rehabilitation services and the focus of the services were mainly on one of the senses, not on the combination of sensory losses. Sensorineural hearing loss in combination with cataracts and age-related macular degeneration were the most common diagnoses. Study II presented older adults experiences of rehabilitation services and they described that several of the rehabilitation services were significant for them to be able to communicate, participate in social events and independently perform day-to-day activities.Conclusion: It is important that rehabilitation services provided to older adults with DSL are person-centred to promote healthy aging.
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| 5. |
- Lundin, Elin, 1976-, et al.
(författare)
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Prevalence, diagnoses and rehabilitation services related to severe dual sensory loss (DSL) in older persons : a cross-sectional study based on medical records
- 2020
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Ingår i: International Journal of Audiology. - : Taylor & Francis. - 1499-2027 .- 1708-8186. ; 59:12, s. 921-929
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To estimate the prevalence of severe dual sensory loss (DSL) among older persons (aged >= 65 years) in the Swedish population, to identify the diagnoses that cause severe DSL, and to identify rehabilitation services in which the participants have been involved.Design: A cross-sectional design was applied. Medical records from Audiological, Low Vision, and Vision clinics from two Swedish counties were used.Study sample: 1257 adults, aged >= 65 years with severe hearing loss (HL) (>= 70 dB HL) were included, whereof 101 had decimal visual acuity <= 0.3.Results: Based on the population size in the two counties (>= 65 years, n = 127,638), the prevalence of severe DSL was approximately 0.08% in the population. Within the group having DSL (n = 101), 61% were women and 71% were aged >= 85 years. Common diagnoses were cataract and/or age-related macular degeneration (AMD) in combination with HL. The rehabilitation services offered were mainly hearing aids and various magnifiers.Conclusions: The study confirmed previous results, indicating that the prevalence of severe DSL increases with age and that sensorineural HL and cataract, AMD or glaucoma coexist. The identified rehabilitation services mainly focussed on either vision loss or HL but not on severe DSL as a complex health condition.
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