| 1. |
- Bixby, H., et al.
(författare)
-
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- 2019
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
-
Tidskriftsartikel (refereegranskat)abstract
- Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
|
|
| 2. |
- Bentham, James, et al.
(författare)
-
A century of trends in adult human height
- 2016
-
Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
|
|
| 3. |
|
|
| 4. |
- Ekström, Erik, et al.
(författare)
-
The effects of microstructure, Nb content and secondary Ruddlesden-Popper phase on thermoelectric properties in perovskite CaMn1-xNbxO3 (x=0-0.10) thin films
- 2020
-
Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 10:13, s. 7918-7926
-
Tidskriftsartikel (refereegranskat)abstract
- CaMn1-xNbxO3 (x = 0, 0.5, 0.6, 0.7 and 0.10) thin films have been grown by a two-step sputtering/annealing method. First, rock-salt-structured (Ca,Mn1-x,Nb-x)O thin films were deposited on 11 & x304;00 sapphire using reactive RF magnetron co-sputtering from elemental targets of Ca, Mn and Nb. The CaMn1-xNbxO3 films were then obtained by thermally induced phase transformation from rock-salt-structured (Ca,Mn1-xNbx)O to orthorhombic during post-deposition annealing at 700 degrees C for 3 h in oxygen flow. The X-ray diffraction patterns of pure CaMnO3 showed mixed orientation, while Nb-containing films were epitaxially grown in [101] out of-plane-direction. Scanning transmission electron microscopy showed a Ruddlesden-Popper (R-P) secondary phase in the films, which results in reduction of the electrical and thermal conductivity of CaMn1-xNbxO3. The electrical resistivity and Seebeck coefficient of the pure CaMnO3 film were measured to 2.7 omega cm and -270 mu V K-1 at room temperature, respectively. The electrical resistivity and Seebeck coefficient were reduced by alloying with Nb and was measured to 0.09 omega cm and -145 mu V K-1 for x = 0.05. Yielding a power factor of 21.5 mu W K-2 m(-1) near room temperature, nearly eight times higher than for pure CaMnO3 (2.8 mu W K-2 m(-1)). The power factors for alloyed samples are low compared to other studies on phase-pure material. This is due to high electrical resistivity originating from the secondary R-P phase. The thermal conductivity of the CaMn1-xNbxO3 films is low for all samples and is the lowest for x = 0.07 and 0.10, determined to 1.6 W m(-1) K-1. The low thermal conductivity is attributed to grain boundary scattering and the secondary R-P phase.
|
|
| 5. |
- Green, Henrik, et al.
(författare)
-
Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer
- 2009
-
Ingår i: Basic & Clinical Pharmacology & Toxicology. - : Wiley-Blackwell Publishing Inc.. - 1742-7835 .- 1742-7843. ; 104:2, s. 130-137
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to evaluate the role of sequence variants in the CYP2C8, ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the pharmacokinetics and toxicity of paclitaxel in ovarian cancer patients. Thirty-eight patients were treated with paclitaxel and carboplatin. The genotypes of CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 and P404A, ABCB1 G2677T/A and C3435T, as well as CYP3A4*1B, were determined by pyrosequencing. Phenotyping of CYP3A4 was performed in vivo with quinine as a probe. The patients were monitored for toxicity and 23 patients underwent a more extensive neurotoxicity evaluation. Patients heterozygous for G/A in position 2677 in ABCB1 had a significantly higher clearance of paclitaxel than most other ABCB1 variants. A lower clearance of paclitaxel was found for patients heterozygous for CYP2C8*3 when stratified according to the ABCB1 G2677T/A genotype. In addition, the CYP3A4 enzyme activity in vivo affected which metabolic pathway was dominant in each patient, but not the total clearance of paclitaxel. The exposure to paclitaxel correlated to the degree of neurotoxicity. Our findings suggest that interindividual variability in paclitaxel pharmacokinetics might be predicted by ABCB1 and CYP2C8 genotypes and provide useful information for individualized chemotherapy.
|
|
| 6. |
|
|
| 7. |
- Gröningsson, Per, et al.
(författare)
-
Coronal emission from the shocked circumstellar ring of SN 1987A
- 2006
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 456:2, s. 581-589
-
Tidskriftsartikel (refereegranskat)abstract
- High resolution spectra with UVES/VLT of SN 1987A from December 2000 until November 2005 show a number of high ionization lines from gas with velocities of ± 350 km s-1, emerging from the shocked gas formed by the ejecta-ring collision. These include coronal lines from [Fe X], [Fe XI] and [Fe XIV] which have increased by a factor of 20 during the observed period. The evolution of the lines is similar to that of the soft X-rays, indicating that they arise in the same component. The line ratios are consistent with those expected from radiative shocks with velocity 310{-}390 km s-1, corresponding to a shock temperature of (1.6{-}2.5)× 106 K. A fraction of the coronal emission may, however, originate in higher velocity adiabatic shocks.
|
|
| 8. |
- Gröningsson, Per, et al.
(författare)
-
High resolution spectroscopy of the inner ring of SN 1987A
- 2008
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 479:3, s. 761-777
-
Tidskriftsartikel (refereegranskat)abstract
- We discuss high resolution VLT/UVES observations (FWHM similar to 6 kms(-1)) from October 2002 (day similar to 5700 past explosion) of the shock interaction of SN 1987A and its circumstellar ring. A large number of narrow emission lines from the unshocked ring, with ion stages from neutral up to Ne V and Fe VII, have been identified. A nebular analysis of the narrow lines from the unshocked gas indicates gas densities of (similar to 1.5 - 5.0) x 10(3) cm(-3) and temperatures of similar to 6.5 x 10(3) - 2.4 x 104 K. This is consistent with the thermal widths of the lines. From the shocked component we observe a large range of ionization stages from neutral lines to [FeXIV]. From a nebular analysis we find that the density in the low ionization region is 4 x 10(6) - 10(7) cm-3. There is a clear difference in the high velocity extension of the low ionization lines and that of lines from [Fe X - XIV], with the latter extending up to similar to- 390 km s(-1) in the blue wing for [Fe XIV], while the low ionization lines extend to typically similar to- 260 km s(-1). For H alpha a faint extension up to similar to- 450 km s(-1) can be seen probably arising from a small fraction of shocked high density clumps. We discuss these observations in the context of radiative shock models, which are qualitatively consistent with the observations. A fraction of the high ionization lines may originate in gas which has yet not had time to cool, explaining the difference in width between the low and high ionization lines. The maximum shock velocities seen in the optical lines are similar to 510 km s(-1). We expect the maximum width of especially the low ionization lines to increase with time.
|
|
| 9. |
- Gröningsson, Per, et al.
(författare)
-
High resolution spectroscopy of the line emission from the inner circumstellar ring of SN 1987A and its hot spots
- 2007
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We discuss high resolution VLT/UVES observations (FWHM ~ 6 km/s) from October 2002 (day ~5700 past explosion) of the shock interaction of SN 1987A and its circumstellar ring. A nebular analysis of the narrow lines from the unshocked gas indicates gas densities of (1.5-5.0)E3 cm-3 and temperatures of 6.5E3-2.4E4 K. This is consistent with the thermal widths of the lines. From the shocked component we observe a large range of ionization stages from neutral lines to [Fe XIV]. From a nebular analysis we find that the density in the low ionization region is 4E6-1E7 cm-3. There is a clear difference in the high velocity extension of the low ionization lines and that of lines from [Fe X-XIV], with the latter extending up to ~ -390 km/s in the blue wing for [Fe XIV], while the low ionization lines extend to typically ~ -260 km/s. For H-alpha a faint extension up to ~ -450 km/s can be seen probably arising from a small fraction of shocked high density clumps. We discuss these observations in the context of radiative shock models, which are qualitatively consistent with the observations. A fraction of the high ionization lines may originate in gas which has yet not had time to cool down, explaining the difference in width between the low and high ionization lines. The maximum shock velocities seen in the optical lines are ~ 510 km/s. We expect the maximum width of especially the low ionization lines to increase with time.
|
|
| 10. |
- Jideus, Lena, et al.
(författare)
-
Thoracic epidural anesthesia does not influence the occurrence of postoperative sustained atrial fibrillation
- 2001
-
Ingår i: Annals of Thoracic Surgery. - 0003-4975 .- 1552-6259. ; 72:1, s. 65-71
-
Tidskriftsartikel (refereegranskat)abstract
- Background. To evaluate whether thoracic epidural anesthesia (TEA) can reduce the incidence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG).Methods. Forty-one patients undergoing CABG were treated with TEA intraoperatively and postoperatively. Another 80 patients served as the control group. The sympathetic and parasympathetic activities were evaluated by analysis of neuropeptides, catecholamines and heart rate variability (HRV), preoperatively and postoperatively.Results. Postoperative AF occurred in 31.7% of the TEA-treated patients and in 36.3% of the untreated patients (p = 0.77). TEA significantly suppressed sympathetic activity, as indicated by a less pronounced increase of norepinephrine and epinephrine (p = 0.03, p = 0.02) and a significant decrease of neuropeptide Y (p = 0.01) postoperatively in TEA-treated patients compared to untreated patients. The HRV variable expressing sympathetic activity was significantly lower and the postoperative increase in heart rate was significantly less in the TEA group than in the control group after surgery (p = 0.01, p < 0.001). Among patients developing AF, the maximal number of supraventricular premature beats per minute increased significantly in untreated patients postoperatively but remained unchanged in TEA-treated patients (p = 0.004 versus p = 0.86).Conclusions. TEA has no effect on the incidence of postoperative sustained AF, despite a significant reduction in sympathetic activity.
|
|
| 11. |
- Lundqvist, Eva, 1985-
(författare)
-
Distal radius fractures AO type C : A clinical and radiographic investigation
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The function of the hand is of substantial importance, and injuries have an impact on daily life. Distal radius fracture (DRF) is the most common fracture among adults. The annual incidence is 26 per 10,000 inhabitants, and the incidence is increasing because of an aging population. There has been a shift from conservative and other operative treatments, toward volar plate fixation to restore the anatomy and improve results. Operative treatment is often considered for displaced and unstable fractures. The optimal choice of treatment and fixation is still debated. The aim of this thesis was to study results after internal fixation of DRF AO type C.Study I (retrospective study, n=74) assessed outcomes after combined plating (CP) of DRFs AO type C, with 1-year follow-up. CP restored the anatomy and achieved a good functional outcome. The radiographic outcome did not correspond to the clinical or functional outcome.Study II (prospective study, n=97) assessed the prevalence of post-traumatic arthritis (PA) following CP of DRFs AO type C. CP yielded a good clinical outcome 7 years postoperatively and the prevalence of PA was low (29%). The presence of PA did not correlate with fracture group, radio-graphic, clinical, or functional outcome. Study III (randomized controlled trial, n=147) assessed the radiographic and clinical outcome following surgical treatment of DRFs AO type C, comparing volar plating (VP) with CP. Fixation with VP yieldedthe same radiographic and functional results as CP, but with a lower frequency of complications in the VP group.Study IV (prospective pilot study, n=10) assessed fragment migration with CTMA (CT-based micromotion analysis) after osteosynthesis with VP after DRF AO type C. The CTMA technique indicated that variable angle volar locking plate fixation can yield and maintain a stable reduction of the fracture fragments. CT volume registration could be a valuable tool in the detailed assessment of fracture fragment migration following VP fixation of DRFs.
|
|
| 12. |
- Lundqvist, Eva, 1985-, et al.
(författare)
-
Posttraumatic Arthritis After Combined Plating of Distal Radius Fractures AO Type C : A 7-Year Follow-up of 97 Cases
- 2022
-
Ingår i: Hand (New York, N.Y.). - : Sage Publications. - 1558-9447 .- 1558-9455. ; :Sup. 1, s. 50S-59S
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Volar locking plate fixation is the most common method of operative fixation of distal radius fractures (DRFs). For more complex cases, combined plating is an option for stabilizing intra-articular fragments. The prevalence of posttraumatic arthritis (PA) after an intra-articular DRF, and its relation to patient-reported outcome measures (PROMs), remains unclear. The purpose of this study was to study the prevalence of PA and its correlation to clinical outcome measures.METHODS: We evaluated 97 consecutive patients with intra-articular DRF, operated with combined plating, 7 years postoperatively. The primary outcome measure was the prevalence of radiographic PA. Secondary outcome measures included visual analog scale (VAS) pain score, hand grip strength, wrist range of motion (ROM), Patient-Rated Wrist Evaluation (PRWE) score, and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score. Radiographic examination was performed between 1 and 7 years postoperatively.RESULTS: The prevalence of PA was 29% at the 7-year follow-up. No correlation was found between PA and ROM, hand grip strength, PRWE, QuickDASH, VAS pain scores, or radiographic reduction. Median wrist ROM and grip strength were significantly inferior compared with the uninjured side. Hardware removal was performed in 51.5% of cases. There were 2 cases of tendon ruptures.CONCLUSIONS: Combined plating can yield a good clinical outcome 7 years postoperatively and a low prevalence of PA. The presence of PA did not correlate to clinical outcome measures or to the accuracy of anatomical reduction 1 year postoperatively. The frequency of tendon ruptures was acceptable, but the high frequency of hardware removal is a concern.
|
|
| 13. |
- Lundqvist, Eva, 1985-, et al.
(författare)
-
Volar Locking Plate Compared With Combined Plating of AO Type C Distal Radius Fractures : A Randomized Controlled Study of 150 Cases
- 2022
-
Ingår i: Journal of Hand Surgery-American Volume. - : Elsevier. - 0363-5023 .- 1531-6564. ; 47:9, s. 813-822
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The optimal way to stabilize intra-articular distal radius fractures is unclear despite recent advances in surgical management. Volar plating is the most common treatment but may not be sufficient for more complex intra-articular AO type C fractures. The purpose of this randomized controlled study was to evaluate the radiographic and clinical outcomes following surgical treatment of AO type C distal radius fractures, comparing volar with combined plating.METHODS: In this study, 150 patients were randomized to volar locking plate (n = 75) or combined plating (n = 75) following a distal radius fracture AO type C. The 1-year follow-up included radiographic outcome (Batra score), visual analog scale pain score, hand grip strength, wrist range of motion, Patient-Rated Wrist Evaluation score, and Quick Disabilities of the Arm, Shoulder, and Hand score.RESULTS: Overall, 147 patients (median age 61 years) completed the 1-year follow-up (73 patients with volar plate and 74 with combined plating). No difference was found in radiographic outcome between the treatment groups. The volar plate group had significantly better Patient-Rated Wrist Evaluation scores, Quick Disabilities of the Arm, Shoulder, and Hand scores, hand grip strength, visual analog scale scores during activity, and flexion, extension, ulnar and radial deviation than the combined plate group. Hardware removal was performed in 10% in the volar plate group and in 31% in the combined plate group. There was no postoperative infection in the volar plate group but 3 cases in the combined plate group.CONCLUSIONS: In patients with complex AO type C intra-articular fractures, volar and combined plating yielded the same radiographic result. The differences in Patient-Rated Wrist Evaluation and Quick Disabilities of the Arm, Shoulder, and Hand scores between the groups did not reach the thresholds for minimal clinically important differences, suggesting similar clinical outcome. The combined plating group had a considerably higher frequency of hardware removal and postoperative infections.TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic I.
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Mölleryd, Bengt A, 1947-
(författare)
-
Governance of innovation - deploying an architectural framework for innovation of technological systems for energy, security and defence
- 2018
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Governance of innovation – deploying an architectural framework for innovation of technological systems for energy, security and defence Innovation has a great deal of attraction but is associated with serious uncertainties and downsides. It is potentially beneficial for growth, sector and industrial development and competitiveness. Innovation brings hope of solving societal challenges, such as climate change and environment protection, and could help secure a supply of energy. Furthermore, it improves resilience and strengthens security and defence.The downside of innovations of some magnitude concern severe transitions and disruptions. Digitisation, with associated net technologies, is an illustrative example of an innovation that creates new services, competitiveness and other benefits which is enormously positive and attractive, while simultaneously dismantles and destroys existing systems, firms and branches, and whole sectors and practices.The thesis deals with promoting innovations at large but specifically systemic, defined as a value-adding (to customers and users) set or convergence of new products/services from technological systems in processes which emerge by evolutionary association and integration of systems transforming businesses, industries and sectors (with disruptions as consequence). Innovations are distinguished by certain structural properties namely systemicitiness. The systemicitiness of innovations suggests a distinct architectural framework that determines the structure of innovations. The purpose of the proposal for an architectural framework for innovation is guidance to governance of innovation. Platform based ecosystems exemplifies an emulation of systemic innovation that aligns with the proposed framework. The framework is distilled from cases, events, patterns, landscapes and models of innovation in the literature, connected with examination of systemicitiness and governance approaches to innovation and innovation processes. The architectural framework is conjected as compatible and complementary to common policies and instruments for innovation and innovation processes as holistic systems engineering, standards and protocols (e.g. ISO/IEC 15288:2015, ISO/IEC 42010:2011, NISP).
|
|
| 17. |
- Nilsson, Kerstin, et al.
(författare)
-
54 forskare: Inte alla klarar höjd pensions-ålder
- 2017
-
Ingår i: Svenska Dagbladet, Stockholm. - 1101-2412.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Ett hållbart och acceptabelt pensionssystem måste utformas utifrån personliga förutsättningar och förhållanden i arbetslivet, så att fler klarar att arbeta i högre ålder. Att enbart genom ekonomiska åtgärder höja pensionsåldern är inte långsiktigt hållbart, skriver 54 forskare.DEBATT | PENSIONForskning visar att cirka var fjärde har en diagnos eller skada orsakad av sitt arbete. Detta gör arbetsorsakad sjukdom och skada till ett betydelsefullt folkhälsoproblem. Att då enbart genom ekonomiska åtgärder höja pensionsåldern för samtliga (yrkes)grupper utifrån deras kronologiska ålder är inte långsiktigt hållbart när individers biologiska ålder är så olika bland annat till följd av arbetslivet. Detta är en demokratifråga. Forskning om äldre i arbetslivet och hållbart arbete visar att man då främst flyttar individer från pensionssystemet till sjukförsäkringssystemet och ökar klyftorna i samhället.Debatt Det här är en argumenterande text med syfte att påverka. Åsikterna som uttrycks är skribentens egna.Vi är 54 forskare som nu gemensamt har skrivit denna debattartikel. Anledningen är att vi är oroade över att cirka var fjärde blir sjuk av sitt arbete samtidigt som man i det förslag som ligger om att senarelägga ålderspensionen i princip utgår ifrån att arbetskraftsdeltagande enbart styrs av ekonomin. Vi vill trycka på betydelsen av åtgärder i arbetslivet för att komma tillrätta med ohälsan, det vill säga inte enbart ekonomiska restriktioner som tvingar folk som inte kan, vill och orkar att stanna kvar i arbetslivet till en högre kronologisk ålder.Pensionssystemet bygger på att vi ska arbeta en viss del av våra liv för att förtjäna möjligheter till pension. Vi bör dock inte enbart utgå ifrån antalet år sedan en person föddes, då korttidsutbildade generellt träder in på arbetsmarknaden tidigare än långtidsutbildade. De har alltså varit en del av arbetskraften från en yngre ålder. Människor med kortare utbildning har oftare ett arbete som innebär påfrestningar som kan inverka negativt på hälsotillståndet och som till och med kan påskynda det biologiska åldrandet. Dessutom lever korttidsutbildade generellt sett inte lika länge som långtidsutbildade, vilket delvis även avspeglar skilda livs- och arbetsvillkor.Den svenska sjukförsäkringsreformen 2008 avsåg att få tillbaka människor i arbete. Men studien fann att den faktiskt bidrog till att fler gick i tidig ålderspension av dem som var i åldern 55–64 år. Ökningen var störst bland korttidsutbildade. Mer än 5 procent fler gick i tidig ålderspension då det blev svårare att få sjukpenning och sjukersättning. Vi kan notera att det är vanligare att manliga chefer tar ut tidig ålderspension, jämfört med kvinnliga maskinskötare inom tillverkningsindustrin. I vissa yrken är det dessutom vanligare att människor, trots pension, både orkar och faktiskt ges möjlighet att arbeta vidare om de har en specialkompetens som efterfrågas. Om vi endast kombinerar ekonomiska morötter med piskor finns en stor risk att vi ökar klyftan mellan grupper som både kan och vill fortsätta att yrkesarbeta och personer som av olika skäl inte längre kan eller orkar.Ta nytta av den forskning som vi har tagit fram. Ett hållbart och acceptabelt pensionssystem måste utformas utifrån personliga förutsättningar och förhållanden i arbetslivet. Ett hållbart arbetsliv för allt fler i vår åldrande befolkning fordrar att vi samtidigt beaktar faktorer som relaterar till biologisk/kroppslig ålder, mental/kognitiv ålder samt social ålder/livsloppsfas och våra attityder som är kopplade till ålder. Vi måste ta större hänsyn till olika förutsättningar och varierande funktionsförmåga och utifrån detta anpassa de åtgärder som gör att arbetslivet blir möjligt och hållbart för allt fler även i högre ålder.”Morötter” är viktigare för en god arbetshälsa och hög produktivitet än en piska i form av oron för en dålig ekonomi.Forskning visar att pedagogik som bygger på ”morötter” oftast är betydligt bättre än ”piskor” för att nå framgångsrika och långsiktiga mål. ”Morötter” i samhället, för organisationer, företag och individer är därför viktiga för god arbetshälsa och fortsatt produktivitet och kan bidra till ett längre arbetsliv även för grupper som tidigare inte ens klarat av att arbeta fram till pensionsåldern. Genom forskning inom området har bland annat swage-modellen utarbetats. Detta är ett verktyg som visar på komplexiteten i ett hållbart arbetsliv och tillsammans med systematiskt arbetsmiljöarbete, handlingsplaner och åtgärder syftar till ett mer hållbart arbetsliv. Morötter är enligt forskningen i detta sammanhang åtgärder för en god fysisk och mental arbetsmiljö, avpassad arbetsbelastning, stödjande teknik, att man kan anpassa arbetstakten, alternativa arbetstidsmodeller vid behov. Det är viktigt att man känner sig trygg och förväntas och tillåts vara delaktig, att man blir sedd av chefen och arbetskamraterna. Att de egna arbetsuppgifterna upplevs som meningsfulla och behövda av andra skapar självförverkligande och tillfredsställelse i arbetet. Att man känner att ens arbetsuppgifter och man själv är viktig för organisationen och företaget. Att man trots högre ålder inkluderas i olika nysatsningar och får tillgång till kompetensutveckling och inte blir åsidosatt eller åldersdiskriminerad. Utvärderingar visar att de äldre medarbetarna som fick några av dessa anpassningar och möjligheter var mer effektiva, utvilade, stimulerade när de var på arbetet samtidigt som sjukfrånvaron minskade. Vilket i sin tur bidrar till ett längre arbetsliv för grupper som tidigare inte klarat av att arbeta fram till pensionsåldern. I organisationer som bygger på en deltagar- och lärandekultur rustas de anställda för att klara omställningar, nya arbetsuppgifter och vid behov även yrkesbyten.Med en åldrande befolkning där allt fler lever allt längre behöver vi arbeta till en högre ålder i framtiden för att pensionssystemet ska hålla. Men ”morötter” är viktigare för en god arbetshälsa och hög produktivitet än en piska i form av oron för en dålig ekonomi. Det kräver också att vi ändrar våra attityder och förhållningssätt till äldre på arbetsmarknaden, vilket vi bäst gör genom att organisationer och företag får incitament till och erbjuder mer individanpassade arbetsvillkor, särskilt för personer i högre ålder. Låt oss därför använda den framtagna kunskapen i praktiken för att göra arbetslivet friskt och hållbart för alla åldrar.
|
|
| 18. |
- Nilsson, Kerstin, et al.
(författare)
-
Vi är oroade över senare ålderspension
- 2017
-
Ingår i: Dagens Samhälle. - 1652-6511.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Var fjärde person blir i dag sjuk till följd av sitt arbete. Att höja pensionsåldern för alla yrkesgrupper, utan konkreta åtgärder för att minska ohälsan, är därför problematiskt och mycket oroande. Det är, enligt forskarna, inte långsiktigt samhällsekonomiskt lönsamt att utan andra åtgärder höja pensionsåldern för alla. Vi – 54 forskare – är mycket oroade över konsekvenserna av att, som föreslagits, senarelägga ålderspensionen.Förslaget utgår i princip från arbetskraftsdeltagande i princip enbart styrs av ekonomin, medan forskningen visar att det bara är en av flera faktorer som styr hur länge och hur mycket människor väljer att arbeta.Det här sättet att lösa problemet med en åldrande befolkning och ett sviktande pensionssystem är inte samhällsekonomiskt lönsamt på lång sikt, utan riskerar bara att flytta runt folk mellan olika ersättningssystem. Pensionssystemet bygger på att vi ska arbeta en viss del av våra liv för att tjäna in vår pension. Vi bör dock inte enbart utgå ifrån ålder eller antalet år sedan en person föddes då korttidsutbildade generellt träder in på arbetsmarknaden tidigare än långtidsutbildade. De med kortare utbildningstid har alltså varit en del av arbetskraften från en yngre ålder. Människor med kortare utbildning har också oftare ett arbete som innebär påfrestningar som kan inverka negativt på hälsotillståndet och som till och med kan påskynda det biologiska åldrandet. Dessutom lever korttidsutbildade generellt sett inte lika länge som långtidsutbildade, vilket delvis även avspeglar skilda livs- och arbetsvillkor.Ta nytta av den forskning som vi har tagit fram. Ekonomin är självklart viktigt för att vi ska vilja arbeta, men den är som sagt enbart en av flera faktorer med betydelse vårt arbetsliv.Hälsotillståndet, både det fysiska och det mentala, har en avgörande betydelse för hur länge och hur mycket vi orkar arbeta. Ett fysiskt och mentalt belastande arbete är en stark riskfaktor för en nedsatt hälsa i slutet av arbetslivet. Arbetstid, arbetstakt och möjlighet till återhämtning spelar en allt större roll ju äldre vi blir. Andra aspekter är arbetsinnehåll, hur meningsfulla och stimulerande arbetsuppgifterna är, balansen mellan arbete och familjesituation och fritidsaktiviteter. Organisationskultur, ledarskapet, stöd i arbetet och kompetens har stor betydelse för om vi ska kunna och vilja arbeta till en högre ålder. Vi måste ta större hänsyn till olika förutsättningar och varierande funktionsförmåga och utifrån detta anpassa de åtgärder som gör att arbetslivet blir möjligt och hållbart för allt fler även i högre ålder.Ett hållbart och acceptabelt pensionssystem måste därför utformas utifrån personliga förutsättningar och förhållanden i arbetslivet. Ett hållbart arbetsliv för allt fler i vår åldrande befolkning fordrar att vi samtidigt beaktar faktorer som relaterar till biologisk/kroppslig ålder, mental/kognitiv ålder samt social ålder/livsloppsfas samt de attityder som är kopplade till ålder.
|
|
| 19. |
- Räftegård, Oskar, et al.
(författare)
-
Energin under mark ska upp till ytan : Strategisk innovationsagenda för geoenergi
- 2016
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The Swedish Strategic Innovation Agenda for Geoenergy develops a strategy for highlighting the need for geoenergy research, development and innovation in relation to the business community and authorities. Sweden has a strong global position in the field. Geothermal energy is the thirdlargest renewable energy source in Sweden, along with wind power. Currently, approximately 18 TWh of renewable heat per year is supplied to household, industrial and commercial buildings. In addition, there is 12 TWh of cooling. There is a great need for a longterm strategy and financial plan for geoenergy research and innovation in Sweden, in order to maintain and further develop research groups and the country's leading position in the field. Today, Swedish research in this field comprises about 14 fulltime positions at universities, institutes and companies. This is little compared to the existing use of geothermal energy, about 19 TWh, which is worth about 15 billion SEK in consumer sales. It is also little in relation to possible future contributions to sustainable development in Sweden and abroad. The agenda is divided into short independent chapters that are tailored to different target groups/ applications. Each chapter consists of an introduction to the current situation, how geoenergy can strategically contribute to a sustainable society, and what actions/needs are a priority.
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
|
|
| 23. |
- Abbes, Yacine
(författare)
-
Educational studies in heat and power technology : how students learn with multimedia tools and problem-based learning
- 2005
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Higher education is undergoing continuous changes and new learning tools and methods are implemented. Researchers in education do not always agree upon the effectiveness of some of the methods introduced into engineering education. The present thesis consists of two case studies on educational methods introduced at the Department of Energy Technology, at Royal Institute of Technology (KTH), Sweden. The qualitative research methodology has been used in case one and a combination of qualitative and quantitative methodology has been used in the second case. The sources of evidences consisted of: unstructured interviews, analysis of video recording, questionnaires, and analysis of a variety of documents. In the first case, an educational program in heat and power technology was analysed. The second case consists in an in-depth study of group dynamics in a Problem –Based Learning course. These studies showed that the learning approach adopted by students depends strongly on the way they view the particular learning tool or method. The first case study revealed the existence of two types of learners. Surfacelearners follow the structure suggested by the designers of the multimedia program. This category of learners focuses only on the material available in the program. Deep-learners go beyond the information and the structure suggested in the program and combine different learning tools in their learning. These students do not follow the structure of the tutorials’ of the multimedia program. This study showed that students who had a strong view how to learn with a multimedia program or a learning method benefited less from the learning tools available. Students with weak views on how to learn from educational program or leaning tool benefit less from the presentation and engage in more surface learning. Self-motivated learners use the multimedia presentation in novel ways and crosscheck the information given with other material. The second study showed that students have unclear and weak views on how to learn with student-directed Problem- Based Learning model. Four types of learners were identified in Problem-Based Learning project: Leaders, Key Actors, Common Students and Social Loafers. Leaders and Key Actors are self-motivated individuals and participate most in the projects. Students who viewed themselves or were viewed as leaders were held responsible to take most of the decisions and students expected them to work more than the average student. Students who viewed themselves as common team members expected a lower workload than leaders’. Key Actors are self-motivated students who do not view themselves as separate from other group members but who participate more than others. Leaders learned more group and social processes, that they did not fully take part in, while common students learned more from the project management aspects that they did not take part in. The study also found that Problem-Based Learning groups can become very cohesive, and can develop distorted views on how to learn with Problem-Based Learning, and un-common group dynamics phenomena such as groupthink can occur in Problem-Based Learning setting.
|
|
| 24. |
- Aberg, Fredrik, et al.
(författare)
-
A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease
- 2021
-
Ingår i: HEPATOLOGY COMMUNICATIONS. - : John Wiley & Sons. - 2471-254X. ; 5:6, s. 1021-1035
-
Tidskriftsartikel (refereegranskat)abstract
- The aspartate-to-alanine aminotransferase ratio (AAR) is associated with liver fibrosis, but its predictive performance is suboptimal. We hypothesized that the association between AAR and liver disease depends on absolute transaminase levels and developed and validated a model to predict liver-related outcomes in the general population. A Cox regression model based on age, AAR, and alanine aminotransferase (ALT) level (dynamic AAR [dAAR]) using restricted cubic splines was developed in Finnish population-based health-examination surveys (FINRISK, 2002-2012; n = 18,067) with linked registry data for incident liver-related hospitalizations, hepatocellular carcinoma, or liver death. The model was externally validated for liver-related outcomes in a Swedish population cohort (Swedish Apolipoprotein Mortality Risk [AMORIS] subcohort; n = 126,941) and for predicting outcomes and/or prevalent fibrosis/cirrhosis in biopsied patients with nonalcoholic fatty liver disease (NAFLD), chronic hepatitis C, or alcohol-related liver disease (ALD). The dynamic AAR model predicted liver-related outcomes both overall (optimism-corrected C-statistic, 0.81) and in subgroup analyses of the FINRISK cohort and identified persons with >10% risk for liver-related outcomes within 10 years. In independent cohorts, the C-statistic for predicting liver-related outcomes up to a 10-year follow-up was 0.72 in the AMORIS cohort, 0.81 in NAFLD, and 0.75 in ALD. Area-under-the-curve (AUC) for detecting prevalent cirrhosis was 0.80-0.83 in NAFLD, 0.80 in hepatitis C, but only 0.71 in ALD. In ALD, model performance improved when using aspartate aminotransferase instead of ALT in the model (C-statistic, 0.84 for outcome; AUC, 0.82 for prevalent cirrhosis). Conclusion: A dAAR score provides prospective predictions for the risk of incident severe liver outcomes in the general population and helps detect advanced liver fibrosis/cirrhosis. The dAAR score could potentially be used for screening the unselected general population and as a trigger for further liver evaluations.
|
|
| 25. |
- Abrahamsson, Maria, et al.
(författare)
-
Steric influence on the excited-state lifetimes of ruthenium complexes with bipyridyl-alkanylene-pyridyl ligands.
- 2008
-
Ingår i: Inorganic Chemistry. - : ACS. - 0020-1669 .- 1520-510X. ; 47:9, s. 3540-3548
-
Tidskriftsartikel (refereegranskat)abstract
- The structural effect on the metal-to-ligand charge transfer (MLCT) excited-state lifetime has been investigated in bis-tridentate Ru(II)-polypyridyl complexes based on the terpyridine-like ligands [6-(2,2'-bipyridyl)](2-pyridyl)methane (1) and 2-[6-(2,2'-bipyridyl)]-2-(2-pyridyl)propane (2). A homoleptic ([Ru(2)(2)](2+)) and a heteroleptic complex ([Ru(ttpy)(2)](2+)) based on the new ligand 2 have been prepared and their photophysical and structural properties studied experimentally and theoretically and compared to the results for the previously reported [Ru(1)(2)](2+). The excited-state lifetime of the homoleptic Ru-II complex with the isopropylene-bridged ligand 2 was found to be 50 times shorter than that of the corresponding homoleptic Ru-II complex of ligand 1, containing a methylene bridge. A comparison of the ground-state geometries of the two homoleptic complexes shows that steric interactions involving the isopropylene bridges make the coordination to the central Ru-II ion less octahedral in [Ru(2)(2)](2+) than in [Ru(1)(2))(2+). Calculations indicate that the structural differences in these complexes influence their ligand field splittings as well as the relative stabilities of the triplet metal-to-ligand charge transfer ((MLCT)-M-3) and metal-centered ((MC)-M-3) excited states. The large difference in measured excited-state lifetimes for the two homoleptic Ru-II complexes is attributed to a strong influence of steric interactions on the ligand field strength, which in turn affects the activation barriers for thermal conversion from (MLCT)-M-3 states to short-lived (MC)-M-3 states.
|
|
| 26. |
- Ademark, Pia, et al.
(författare)
-
Hydrolytic properties of a beta-mannosidase purified from Aspergillus niger. J. Biotechnol. 75: 281-289.
- 1999
-
Ingår i: Journal of Biotechnology. - 1873-4863. ; 75:2-3, s. 281-289
-
Tidskriftsartikel (refereegranskat)abstract
- A β-mannosidase was purified to homogeneity from the culture filtrate of Aspergillus niger. A specific activity of 500 nkat mg−1 and a 53-fold purification was achieved using ammonium sulfate precipitation, anion-exchange chromatography, and gel filtration. The isolated enzyme has an isoelectric point of 5.0 and appears to be a dimer composed of two 135-kDa subunits. It is a glycoprotein and contains 17% N-linked carbohydrate by weight. Maximal activity was observed at pH 2.4–5.0 and at 70°C. The β-mannosidase hydrolyzed β-1,4-linked manno-oligosaccharides of degree of polymerization (DP) 2–6 and also released mannose from polymeric ivory nut mannan and galactomannan. The Km and Vmax values for p-nitrophenyl-β-Image-mannopyranoside were 0.30 mM and 500 nkat mg−1, respectively. Hydrolysis of Image-galactose substituted manno-oligosaccharides showed that the β-mannosidase was able to cleave up to, but not beyond, a side group. An internal peptide sequence of 15 amino acids was highly similar to that of an Aspergillus aculeatus β-mannosidase belonging to family 2 of glycosyl hydrolases.
|
|
| 27. |
- Ahl, Amanda, et al.
(författare)
-
Balancing formal and informal success factors perceived by supply chain stakeholders : A study of woody biomass energy systems in Japan
- 2018
-
Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786. ; 175, s. 50-59
-
Tidskriftsartikel (refereegranskat)abstract
- Small-scale woody biomass energy systems have an inherent ability to aid in emissions reduction while stimulating local economies and, as collective energy systems, are strongly connected to supply chain design based on local conditions and stakeholder integration. Despite an abundance of forest area alongside the promotion of biomass in energy policies, however, woody biomass utilization still remains low in Japan. The woody biomass supply chain, considered as a socio-technical system, involves a complex, cross-sectoral stakeholder network in which inter-organizational dynamics necessitates well-organized management based on an understanding of formal factors such as technology, as well as informal factors such as social relations and culture. In this paper, success factor perceptions from across the woody biomass supply chain are investigated based on semi-structured interviews with four stakeholders in the Kyushu region of Japan. Identified success factors here are: 1) respect of values & traditions, 2) transportation infrastructure, 3) business model integration, 4) relationship & trust, 5) local vitalization and 6) biomass quality control. A convergence as well as divergence of perceptions are observed, involving both formal and informal dimensions. Aiming to balance perceptions and to enable long-term success of woody biomass in Japan, a series of policy implications are drawn, including cross-ministerial integration, knowledge building on wood logistics, forest certification, local coordinators, biomass quality control standards and a feed-in-tariff for heat. This paper suggests a new arena of policy-making based on the importance of considering both informal and formal dimensions in energy policy.
|
|
| 28. |
- Al Saad, Tamy, et al.
(författare)
-
Kunskap och lärande genom projektsamverkan : utmaningar och möjligheter. Följeforskning av ett samverkansprojekt i Vänersborgs kommun.
- 2022
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Under 2021 beviljades Vänersborgs kommun statsbidrag från Delegationen mot segregation (Delmos) för ett samverkansprojekt mellan det lokala brottsförebyggande rådet och den kommunala arbetsgruppen Samverkan för social inkludering. Projektet kallas Delmosprojektet och syftar till att skapa mer jämlika och jämställda förutsättningar för medborgarna i den socioekonomiskt utsatta stadsdelen Torpa att påverka sina liv. Samverkansarbete är ett nytt arbetssätt inom Vänersborgs kommun, där man hoppas hitta långsiktiga sätt att samverka kring det brottsförebyggande och trygghetsskapande arbetet.För att kvalitetssäkra arbetet i Delmosprojektet och ta fram underlag för fortsatt metodutveckling fick forskargruppen Samskapande hållbar samhällsutveckling (SHS) vid Högskolan Väst i uppdrag att genom observationer och intervjuer genomföra följeforskning. Forskningen genomfördes utifrån ett deltagarperspektiv och under projektets inledande fas, från september 2021 till januari 2022. Denna rapport är en både beskrivande och analytisk sammanfattning av projektet under den här tiden, med målet att illustrera utmaningar och möjligheter när det gäller kunskapsöverföring mellan de samverkansaktörer som representerar Vänersborgs kommun. Analysen är gjord utifrån ett arbetsintegrerat lärandeperspektiv och inkluderar faktorer som anses påverka lärprocesserna, såsom absorptionsförmåga, systematisk kommunikation, projektroller, gruppdynamik, gemensamma mål, tillit och relationer samt tidspress.Generellt uppfattas Delmosprojektet som positivt och dess mål som viktigt. Samarbetet i arbetsgrupperna beskrivs som väl fungerande med givande diskussioner i en trygg och inkluderande miljö. Genom medborgardialoger visar kommunen stort förtroende för och tillit till medborgarna och deras kunskaper och erfarenheter av området. Projektdeltagarna förstår vikten av medborgarperspektivet och önskar att det även fortsättningsvis är en del av kommunens arbete.Samtidigt uttrycker deltagarna att det finns utmaningar, framför allt i form av otydlighet kring projektstruktur, roller och gemensamma mål. De efterfrågar mer information kring projektet som helhet, men även en struktur för kommunikation mellan grupper och inom de olika förvaltningarna. Likt inom många andra kommunala projekt önskas också mer tid och resurser.Följeforskningen har funnit goda exempel att ta vara på inför framtida projekt men också möjligheter till utveckling. Att förankra kommande projekt är en viktig förutsättning för deras start och fortlevnad, och därtill krävs systematiska kommunikationsvägar, långsiktiga mål och ständiga utvärderingar. Att medborgarnas röster måste vara ledande i arbetet finns det inga tvivel om, men rapporten lämnar utrymme för frågor kring hur man bäst når medborgare som i vanliga fall inte kan eller vill nås.
|
|
| 29. |
- Alling, Christer, et al.
(författare)
-
Adaptation of signal transduction in brain
- 1994
-
Ingår i: EXS. - 1023-294X. ; 71, s. 19-28
-
Tidskriftsartikel (refereegranskat)abstract
- Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.
|
|
| 30. |
- Almstedt, Karin, 1980-, et al.
(författare)
-
Unfolding a folding disease: folding, misfolding and aggregation of the marble brain syndrome-associated mutant H107Y of human carbonic anhydrase II
- 2004
-
Ingår i: Journal of Molecular Biology. - Oxford : Elsevier. - 0022-2836 .- 1089-8638. ; 342:2, s. 619-633
-
Tidskriftsartikel (refereegranskat)abstract
- Most loss-of-function diseases are caused by aberrant folding of important proteins. These proteins often misfold due to mutations. The disease marble brain syndrome (MBS), known also as carbonic anhydrase II deficiency syndrome (CADS), can manifest in carriers of point mutations in the human carbonic anhydrase II (HCA II) gene. One mutation associated with MBS entails the His107Tyr substitution. Here, we demonstrate that this mutation is a remarkably destabilizing folding mutation. The loss-of-function is clearly a folding defect, since the mutant shows 64% of CO2 hydration activity compared to that of the wild-type at low temperature where the mutant is folded. On the contrary, its stability towards thermal and guanidine hydrochloride (GuHCl) denaturation is highly compromised. Using activity assays, CD, fluorescence, NMR, cross-linking, aggregation measurements and molecular modeling, we have mapped the properties of this remarkable mutant. Loss of enzymatic activity had a midpoint temperature of denaturation (Tm) of 16 °C for the mutant compared to 55 °C for the wild-type protein. GuHCl-denaturation (at 4 °C) showed that the native state of the mutant was destabilized by 9.2 kcal/mol. The mutant unfolds through at least two equilibrium intermediates; one novel intermediate that we have termed the molten globule light state and, after further denaturation, the classical molten globule state is populated. Under physiological conditions (neutral pH; 37 °C), the His107Tyr mutant will populate the molten globule light state, likely due to novel interactions between Tyr107 and the surroundings of the critical residue Ser29 that destabilize the native conformation. This intermediate binds the hydrophobic dye 8-anilino-1-naphthalene sulfonic acid (ANS) but not as strong as the molten globule state, and near-UV CD reveals the presence of significant tertiary structure. Notably, this intermediate is not as prone to aggregation as the classical molten globule. As a proof of concept for an intervention strategy with small molecules, we showed that binding of the CA inhibitor acetazolamide increases the stability of the native state of the mutant by 2.9 kcal/mol in accordance with its strong affinity. Acetazolamide shifts the Tm to 34 °C that protects from misfolding and will enable a substantial fraction of the enzyme pool to survive physiological conditions.
|
|
| 31. |
- Alänge, Sverker, 1951, et al.
(författare)
-
ISO 9000: Erfarenheter från certifierade företag
- 1993
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Idag har många svenska företag fått ISO 9000-certifikat genom tredjeparts bedömning, antingen via SIS, Norsk Veritas, Lloyd's eller British Standard Institute. De flesta företagen har antingen certifierats enligt ISO 9001 eller ISO 9002. I september 1992 hade 34 företag certifierats genom Norsk Veritas och det fanns 72 certifierade företag på SIS lista.Det finns dock många olika synpunkter angående värdet av en certifiering. Vissa anser att den är grundläggande för ett gott kvalitetsarbete och andra anser att det verkar vara en krånglig pappersexercis utan större inverkan på kvalitetsresultatet. Juran väckte en del uppståndelse och eftertanke när han 1989 sa "Se gärna till att uppfylla ISO 9000 men låt det inte störa kvalitetsarbetet".Denna rapport baseras på en undersökning för att ta reda på hur det verkligen förhåller sig i svenska företag. Den är utförd av teknologer som deltagit i en kurs i "Industriell kvalitetsteknik" vid Chalmers tekniska högskola. Var och en av teknologerna har haft som uppgift att ta kontakt med ett svenskt företag som certifierats enligt ISO 9001 eller ISO 9002. Uppgiften gällde att undersöka vilka positiva och negativa erfarenheter de certifierade företagen har av certifieringsprocessen och vilka resultat de uppnått internt och externt på grund av ISO 9000.Teknologerna delades in i grupper om 5-7 personer där var och en ringde ett företag under november-december 1992. Därefter sammanställde varje grupp en liten rapport baserad på 5-7 intervjuer. De analyserade de viktigaste positiva och negativa synpunkterna från dessa intervjuer. De undersökte om det fanns något gemensamt i svaren, eller om företagen hade olika erfarenheter och då försökte de komma fram till vad detta kunde bero på.Genom den egna direkta kontakten med ett företag och den gruppvisa diskussionen och författandet av en rapport har teknologerna kunna skaffa sig egna kunskaper om ISO 9000. I storgrupp presenterade därefter de olika smågrupperna sina rapporter och diskuterade resultaten. Baserat på denna diskussion, smågruppsrapporterna och ifyllda intervjuformulär har därefter tre teknologer sammanställt resultatet till föreliggande rapport.
|
|
| 32. |
- Andersson, Catrine, 1982-
(författare)
-
Hundra år av tvåsamhet : Äktenskapet i svenska statliga utredningar 1909-2009
- 2011
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the thesis is to study the concept of marriage and discursive constructions linked to marriage in Swedish policy documents, SOU, 1909-2009. Focusing on marriage as a formal institution, and on form, rather than content – marriage is considered one of several ways of regulating intimate relationships, and the analysis is thus centred on the intimate and erotic aspects of marriage as an institution. Using queer and sociological theories on late modern intimacy, state regulation and concepts of norms, theoretical tools which make possible exploring historical discursive shifts of heteronormativity and coupledom are developed. Policy documents (SOU) are analysed using discourse analysis inspired by archaeology and history of concepts. In three chapters, each covering a part of the period 1909-2009, the discursive landscape of state intervention in marital and other coupled relations is traced. Three themes emerge in this analysis. Firstly, a discursive movement can be seen, from marriage, as a morally superior form of relation, to family, as one of several more or less encouraged forms of relations. Secondly, in using the theoretical framework of heteronormativity, it is suggested that heteronormativity is reshaped in paradoxical ways. The seemingly non-heteronormative, gender neutral marriage law introduced in 2009 was built discursively on a concept of love used from the 1980s in these materials for motivating extended civil rights for homosexuals. It was, however, a logic of love based on difference and essentialised homosexual identity. A non-heteronormative law was thus introduced on a heteronormative discursive basis, enforcing extended norms of coupledom in the process. Thirdly, the question of what discursive role marriage plays in relation to society is explored. By enforcing differentiation between sexual and non-sexual, reproductive and non-reproductive, coupled and non-coupled relationships, social order is maintained. For one hundred years, despite major changes, coupledom is constant.
|
|
| 33. |
|
|
| 34. |
- Andersson, Linda, 1973, et al.
(författare)
-
Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.
- 2017
-
Ingår i: The international journal of biochemistry & cell biology. - : Elsevier BV. - 1878-5875 .- 1357-2725. ; 91:Pt A, s. 9-13
-
Tidskriftsartikel (refereegranskat)abstract
- Myocardial triglycerides stored in lipid droplets are important in regulating the intracellular delivery of fatty acids for energy generation in mitochondria, for membrane biosynthesis, and as agonists for intracellular signaling. Previously, we showed that deficiency in the lipid droplet protein perilipin 5 (Plin5) markedly reduces triglyceride storage in cardiomyocytes and increases the flux of fatty acids into phospholipids. Here, we investigated whether Plin5 deficiency in cardiomyocytes alters mitochondrial function. We found that Plin5 deficiency reduced mitochondrial oxidative capacity. Furthermore, in mitochondria from Plin5((-/)(-)) hearts, the fatty acyl composition of phospholipids in mitochondrial membranes was altered and mitochondrial membrane depolarization was markedly compromised. These findings suggest that mitochondria isolated from hearts deficient in Plin5, have specific functional defects.
|
|
| 35. |
- Andersson, Linda, 1973, et al.
(författare)
-
Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischemia
- 2015
-
Ingår i: Cardiovascular Research. - : Oxford University Press (OUP). - 0008-6363 .- 1755-3245. ; 107:4, s. 478-486
-
Tidskriftsartikel (refereegranskat)abstract
- In myocardial ischemia, vascular endothelial growth factor (VEGF) induces permeability by activating a signalling pathway that includes VEGF receptor 2 (VEGFR2), resulting in increased oedema and inflammation and thereby expanding the area of tissue damage. In this study, we investigated the role of receptor-interacting protein 2 (Rip2) in VEGF signalling and myocardial ischemia/reperfusion injury.
|
|
| 36. |
|
|
| 37. |
|
|
| 38. |
- Anthon, Carl Thomas, et al.
(författare)
-
Thrombocytopenia and platelet transfusions in ICU patients : an international inception cohort study (PLOT-ICU)
- 2023
-
Ingår i: Intensive Care Medicine. - 0342-4642. ; 49:11, s. 1327-1338
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Thrombocytopenia (platelet count < 150 × 10 9/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. METHODS: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.RESULTS: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).CONCLUSION: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.
|
|
| 39. |
- Anund Vogel, Jonas, 1981-, et al.
(författare)
-
Co-Creation in Living Labs to Accelerate Innovation
- 2020
-
Ingår i: Civil Engineering Research Journal. - Irvine California United States : Juniper Publishers. - 2575-8950. ; 10:1
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Innovation in the construction sector occurs as stepwise reconfigurations of subsystems, but sometimes the effect of many systems coincides and there is so called radical change. Stepwise reconfigurations of individual systems such as windows, insulation, and heat recovery systems have made it possible to heat buildings with preheated inlet air instead of water radiators. Thus, making building more sustainable, cheaper and resource-efficient; the potential for radical change has been achieved. The question is then why not every new building uses preheated inlet air? The reason is not the lack of innovation or new technologies. It is rather connected to malfunctioning structures related to incentives, collaboration, testing, and validation, resulting in norms and standards that aim to reproduce existing technologies, preferring incremental innovations over radical ones.This article argues that testbeds and Living Labs are a way to work on complex, multi-stakeholder and urgent problems in a co-creative way. In these labs there are possibilities to test technologies, in systems, in real buildings and cities. There are possibilities to follow-up, measure and adjust; to live, study, work and develop. The Living Labs have the potential of making new technologies standard to use in the course of years instead of decades and thus minimize unnecessary use of resources linked to the construction and use of buildings. In addition, it will help to make technologies more user-friendly, considering user needs, wishes and experiences, thus contributing to the effectiveness of the technologies developed and tested.
|
|
| 40. |
- Anund Vogel, Jonas, 1981-
(författare)
-
Incentivising Innovation in the Swedish Construction Industry
- 2020
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Almost 40 percent of global final energy use and CO2 emissions are connected to buildings and building-related activities; it is therefore important to incentivise the design and construction of resource-efficient buildings. Unfortunately, energy demand and associated emissions in the sector continue to grow. Such incentives will help achieve energy and environmental targets, reduce costs, and make smart and sustainable buildings and cities possible at a larger scale. Because novel technologies carry risks alongside their advantages, developers, contractors and consultants must have incentives to reduce and share those risks in a rational way if we are to meet the crucial long-term societal goals of reduced use of resources and emissions. I hypothesise that there are legal and institutional frameworks (rules, building codes, regulations, standard contracts, etc.) that result in weak or negative incentives for construction industry actors to invest in, propose, and install resource-efficient technologies. If the hypothesis holds true, then the goal is to identify ways to better incentivise construction industry actors to fully engage in the design and construction of smart and sustainable buildings. To tackle this, four studies were carried out using a mixed-method approach. Paper 1 identifies 38 barriers to energy efficiency in Swedish multifamily buildings. The next study (Paper 2) develops a categorisation framework in order to understand where to engage to overcome or bypass barriers to energy efficiency. Paper 3 and 4 are devoted to analysing two sets of barriers and propose possible solutions to overcome or avoid them: (1) how the current legal framework guiding start and operation of housing co-operatives (mainly the Co-operative Act) influences incentives for engaging in resource-efficient construction, and (2) how the legal instrument for collaboration between developers and consultants incentivises resource-efficient construction. In this case, the contract under investigation is the General Conditions of Contract for Consulting Agreements for Architectural and Engineering Assignments (ABK 09)”. Changes to these two sets of legal and institutional frameworks could have a significant impact on how buildings are designed, produced and used. The changes proposed could incentivise construction industry actors to fully pursue the creation of smart, sustainable buildings that deliver services to users and reduce negative environmental impacts stemming from both the building construction and operation phases.
|
|
| 41. |
- Anund Vogel, Jonas, 1981-, et al.
(författare)
-
Problem areas related to energy efficiency implementation in Swedish multifaily buildings
- 2015
-
Ingår i: Energy Efficiency. - : Springer. - 1570-646X .- 1570-6478.
-
Tidskriftsartikel (refereegranskat)abstract
- This paper investigates problem areas related to energy efficiency implementation in Swedish multifamily buildings. The paper first presents a generic list of (theoretical) problem areas identified through a literature survey. Using a qualitative approach, the paper also investigates if the problem areas identified in the literature also have an impact on the Swedish building sector. Results from the interview study reveal a strong coherence between problem areas in the literature and those expressed by the interviewees. However, this paper identifies seven novel challenges that cannot be derived from the list of barriers in the literature. Moreover, results reveal that as many as 12 problem areas have their origin in national factors such as agreement structures, incentive schemes, and cost calculation methods.
|
|
| 42. |
- Anund Vogel, Jonas, 1981-, et al.
(författare)
-
Who is Governing the Commons : Studying Swedish Housing Cooperatives
- 2016
-
Ingår i: Housing, Theory and Society. - : Taylor & Francis. - 1403-6096 .- 1651-2278. ; 33:4, s. 424-444
-
Tidskriftsartikel (refereegranskat)abstract
- This study examines current governance structures related to multifamily buildings designed by single actors (developers) and operated in cooperative forms. The study analyses the long-term sustainability of the resource regime of study (multifamily buildings) and inked governance structures by applying Ostrom’s eight design principles for long-term survival of self-organized resource regimes (Common-pool resources or CPR’s). The study also searches for signs of movement towards social innovation and collective action in current governance structures. We argue that the structures governing planning, production and operation of housing cooperatives in Sweden do not fulfil the eight design principles for the long-term survival of the resource regime of study, nor do they encourage movement towards social innovation or collective action. In order to ensure the long-term survival of the resource regime of study and to increase innovation in governance structures, five adjustments are proposed; changes in the structures governing risk/profit distribution, communication, collaboration and information between actors in the Swedish cooperative housing sector.
|
|
| 43. |
|
|
| 44. |
- Arias, Jaime, 1957-
(författare)
-
Energy Usage in Supermarkets - Modelling and Field Measurements
- 2005
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis investigates a special type of energy system, namely energy use in supermarkets through modelling, simulations and field studies. A user-friendly computer program, CyberMart, which calculates the total energy performance of a supermarket, is presented. The modelling method described in this thesis has four phases: the first phase is the de-velopment of a conceptual model that includes its objectives, the envi-ronment and the components of the system, and their interconnections. The second phase is a quantitative model in which the ideas from the conceptual model are transformed into mathematical and physical rela-tionships. The third phase is an evaluation of the model with a sensitivity analysis of its predictions and comparisons between the computer model and results from field measurements. The fourth phase is the model ap-plication in which the computer model answers questions identified in the beginning of the modelling process as well as other questions arising throughout the work. Field measurements in seven different supermarkets in Sweden were car-ried out to: (i) investigate the most important parameters that influence energy performance in supermarkets, (ii) analyse the operation of new system designs with indirect system implementation in Sweden during recent years, and (iii) validate the computer model. A thorough sensitivity analysis shows a total sensitivity of 5.6 %, which is a satisfactory result given a 10% change in the majority of input parame-ters and assumptions, with the exception of outdoor temperatures and solar radiation that were calculated as extreme values in METEO-NORM. Comparisons between measurements and simulations in five supermarkets also show a good agreement. Measurements and simula-tion results for a whole year were not possible due to lack of data. CyberMart opens up perspectives for designers and engineers in the field by providing innovative opportunities for assessment and testing of new energy efficient measures but also for evaluation of different already-installed system designs and components. The implementation of new energy-saving technologies in supermarkets requires an extensive inte-grated analysis of the energy performances of the refrigeration system, HVAC system, lighting, equipment, and the total energy usage. This analysis should be done over a long period, to evaluate and compare the real energy performance with the theoretical values calculated by Cyber-Mart.
|
|
| 45. |
|
|
| 46. |
- Arias, Jaime M., et al.
(författare)
-
Heat recovery and floating condensing in supermarkets
- 2006
-
Ingår i: Energy and Buildings. - : Elsevier BV. - 0378-7788 .- 1872-6178. ; 38:2, s. 73-81
-
Tidskriftsartikel (refereegranskat)abstract
- Supermarkets are great energy users in many countries. The potential for increased energy efficiency is large. One option is to utilize heat recovery (or heat reclaim) from condensers to heat the premises. Obviously this option is only interesting in relatively cold areas such as northern Europe, Canada, etc. An alternative to heat recovery is floating condensing pressure, which improves the coefficient of performance and decreases the energy consumption of the refrigeration system at lower outdoor temperature. Both heat recovery and floating condensing pressure can be utilized interchangeably depending on the heat requirements of the premises. A computer model that calculates the energy consumption in a supermarket with the possibility to simulate different system solutions for the refrigeration system has been developed at the Royal Institute of Technology, Department of Energy Technology. The software CyberMart is used in the present study to compare the potential of heat recovery and floating condensing in Swedish supermarkets. Measurements of different parameters such as temperatures, relative humidity and compressor power have been carried out in different supermarkets with heat recovery to validate the theoretical calculations. The present study shows that heating requirements can be covered completely by heat reclaim from the condenser. However, practical experiences show that installations are less efficient due to poor system solutions and/or control strategies. According to the results from CyberMart, the highest potential of energy saving is obtained from using a systems solution with both heat recovery and floating condensing.
|
|
| 47. |
- Arias, Jaime M., et al.
(författare)
-
Modelling and experimental validation of advanced refrigeration systems in supermarkets
- 2005
-
Ingår i: Proceedings of the Institution of mechanical engineers. Part E, journal of process mechanical engineering. - : SAGE Publications. - 0954-4089 .- 2041-3009. ; 219:E2, s. 149-156
-
Tidskriftsartikel (refereegranskat)abstract
- The effective use of energy and the replacement of CFC and HCFC refrigerants are two factors that have influenced the design and operation of refrigeration systems in supermarkets during recent years. The potential for increasing energy efficiency in refrigeration systems, indoor climate and refrigerated cabinets is large. Since the energy systems of a supermarket are relatively complex, improvements in one subsystem affect other systems, thus making analysis of potential improvements non-additive. A computer model, CyberMart, that predicts building heating and cooling loads, HVAC (heating, ventilation, and air conditioning), and refrigeration system performances of a supermarket, has been developed. The focus of the model is on energy use, environmental impact (TEWI), and life cycle cost (LCC) of the refngeration system. The refrigeration system solutions included in the model are: direct system, completely indirect system, partially indirect system, cascade system, parallel system with mechanical sub-cooling (where the refrigerant in the low-temperature system is sub-cooled with the brine of the intermediate temperature level), and district cooling (that cools the condenser of the refrigeration machines). Measurements of different parameters such as outdoor and indoor temperatures, relative humidity, and compressor power have been carried out in several stores to validate the model. A theoretical description of the model and results from the model and measurements are presented in this paper.
|
|
| 48. |
|
|
| 49. |
|
|
| 50. |
|
|
