| 1. |
- Chen, Ping, et al.
(författare)
-
A Linear Relation between the Color Stretch sBV and the Rising Color Slope s0*(B – V) of Type Ia Supernovae
- 2023
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 946:2
-
Tidskriftsartikel (refereegranskat)abstract
- Using data from the Complete Nearby (redshift zhost < 0.02) sample of Type Ia Supernovae (CNIa0.02), we find a linear relation between two parameters derived from the B − V color curves of Type Ia supernovae: the color stretch sBV and the rising color slope s0*(B – V) after the peak, and this relation applies to the full range of sBV. The sBV parameter is known to be tightly correlated with the peak luminosity, especially for fast decliners (dim Type Ia supernovae), and the luminosity correlation with sBV is markedly better than with the classic light-curve width parameters such as Δm15(B). Thus, our new linear relation can be used to infer peak luminosity from s0*. Unlike sBV (or Δm15(B)), the measurement of s0*(B – V) does not rely on a well-determined time of light-curve peak or color maximum, making it less demanding on the light-curve coverage than past approaches.
|
|
| 2. |
- Dahm-Kähler, Pernilla, 1964, et al.
(författare)
-
Population-based study of survival for women with serous cancer of the ovary, fallopian tube, peritoneum or undesignated origin - on behalf of the Swedish gynecological cancer group (SweGCG)
- 2017
-
Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 144:1, s. 167-173
-
Tidskriftsartikel (refereegranskat)abstract
- Objective. The aim of the study was to determine survival outcome in patients with serous cancer in the ovary, fallopian tube, peritoneum and of undesignated origin. Methods. Nation-wide population-based study of women 18 years with histologically verified non-uterine serous cancer, included in the Swedish Quality Registry for primary cancer of the ovary, fallopian tube and peritoneum diagnosed 2009-2013. Relative survival (RS) was estimated using the Ederer II method. Simple and multivariable analyses were estimated by Poisson regression models. Results. Of 5627 women identified, 1246 (22%) had borderline tumors and 4381 had malignant tumors. In total, 2359 women had serous cancer; 71% originated in the ovary (OC), 9% in the fallopian tube (FTC), 9% in the peritoneum (PPC) and 11% at an undesignated primary site (UPS). Estimated RS at 5-years was 37%; for FTC 54%, 40% for OC, 34% for PPC and 13% for UPS. In multivariable regression analyses restricted to women who had undergone primary or interval debulldng surgery for OC, FTC and PPC, site of origin was not independently associated with survival. Significant associations with worse survival were found for advanced stages (RR 2.63, P<0.001), moderate (RR 1.90, P<0.047) and poor differentiation (RR 2.20, P<0.009), neoadjuvant chemotherapy (RR1.33, P<0.022), residual tumor (RR 2.65, P<0.001) and platinum single (2.34, P<0.001) compared to platinum combination chemotherapy. Conclusion. Survival was poorer for serous cancer at UPS than for ovarian, fallopian tube and peritoneal cancer. Serous cancer at UPS needs to be addressed when reporting and comparing survival rates of ovarian cancer. (C) 2016 Elsevier Inc. All rights reserved.
|
|
| 3. |
- Olsson, Cecilia, 1971-, et al.
(författare)
-
Adaption of the Quality From the Patient’s Perspective Instrument for Use in Assessing Gynecological Cancer Care and Patients’ Perceptions of Quality Care Received
- 2022
-
Ingår i: Cancer Care Research Online. - : Wolters Kluwer. - 2691-3623. ; 2:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Research focusing on patients’ perceptions of the quality of gynecological cancer care is needed.Objective: To adapt the Quality from the Patient’s Perspective instrument for use in gynecological cancer care (QPP-GynCa) and describe patients’ perceptions of their quality of care in terms of the care received and the subjective importance of the aspects of care.Methods: A cross-sectional study 6–8 months after diagnosis was conducted, involving 1511 patients (response rate of 50.4%) included in the Swedish quality registry for gynecologic cancer.Results: The exploratory factor analysis (n = 1431) resulted in the QPP-GynCa with a 5-factor structure and an eigenvalue of ≥1, explaining 73.1% of the total scale variance. The final 27-item version of the QPP-GynCa consisted of 18 items with 8 additional single items and 1 global single item. The Cronbach’s alpha was acceptable for most factors (>.80). Subjective importance scores were higher than corresponding quality of care scores for care received (P ≤ .01)in all dimensions, factors, and items.Conclusions: The QPP-GynCa instrument reflects all 4 dimensions of the theoretical model of quality of care and achieved good validity as a reliable instrument in assessing the quality of gynecological cancer care.Implication for Practice: Information related to self-care, aspects of sexuality, and reducing patient waiting times need improvement.What Is Foundational: This study contributes to a better understanding of quality of gynecological cancer treatment and care. The validated QPP-GynCa instrument will be a platform for more research on how this group of patients experience their received care, as well as importance of each aspect of care.
|
|
| 4. |
- Radestad, A. F., et al.
(författare)
-
Long-term incidence of endometrial cancer after endometrial resection and ablation: A population based Swedish gynecologic cancer group (SweGCG) study
- 2022
-
Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 101:8, s. 923-930
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction Minimally invasive methods to reduce menorrhagia were introduced in the 1980s and 1990s. Transcervical endometrial resection (TCRE) and endometrial ablation (EA) are two of the most frequently used methods. As none of them can guarantee a complete removal of the endometrium, there are concerns that the remaining endometrium may develop to endometrial cancer (EC) later in life. The primary aim was to analyze the long-term incidence of EC after TCRE and EA in a nationwide population. The secondary aim was to assess the two treatment modalities separately. Material and Methods The Swedish National Patient Registry and National Quality Registry for Gynecological Surgery were used for identification of women who had TCRE or EA performed between 1997-2017. The cohort was followed from the first TCRE or EA until hysterectomy, diagnosis of EC, or death. Follow-up data were retrieved from the National Cancer Registry and the National Death Registry. Expected incidence for EC in Swedish women was calculated using Swedish data retrieved from the NORDCAN project after having taken into account differences of age and follow-up time. Cumulative incidence of EC after TCRE and EA, was calculated. A standardized incidence ratio was calculated based on the expected and observed incidence, stratified by age and year of diagnosis. Results In total, 17 296 women (mean age 45.1 years) underwent TCRE (n = 8626) or EA (n = 8670). Excluded were 3121 who had a hysterectomy for benign causes during follow up. During a median follow-up time of 7.1 years (interquartile range 3.1-13.3 years) the numbers of EC were 25 (0.3%) after TCRE and 2 (0.02%) after EA, respectively. The observed incidence was significantly lower than expected (population-based estimate) after EA but not after TCRE, giving a standardized incidence ratio of 0.13 (95% confidence interval [CI] 0.03-0.53) after EA and 1.27 (95% CI 0.86-1.88) after TCRE. Median times to EC were 3.0 and 8.3 years after TCRE and EA, respectively. Conclusions There was a significant reduction of EC after EA, suggesting a protective effect, whereas endometrial resection showed an incidence within the expected rate.
|
|
| 5. |
- de Blanche, Andreas, 1975-, et al.
(författare)
-
Disallowing Same-program Co-schedules to Improve Efficiency in Quad-core Servers
- 2017
-
Ingår i: Proceedings of the Joined Workshops COSH 2017 and VisorHPC 2017. - 9783000555640 ; , s. 1-7
-
Konferensbidrag (refereegranskat)abstract
- Programs running on different cores in a multicore server are often forced to share resources like off-chip memory,caches, I/O devices, etc. This resource sharing often leads to degraded performance, a slowdown, for the program sthat share the resources. A job scheduler can improve performance by co-scheduling programs that use different resources on the same server. The most common approachto solve this co-scheduling problem has been to make job schedulers resource aware, finding ways to characterize and quantify a program’s resource usage. We have earlier suggested a simple, program and resource agnostic, scheme as a stepping stone to solving this problem: Avoid Terrible Twins, i.e., avoid co-schedules that contain several instances from the same program. This scheme showed promising results when applied to dual-core servers. In this paper, we extend the analysis and evaluation to also cover quad-core servers. We present a probabilistic model and empirical data that show that execution slowdowns get worse as the number of instances of the same program increases. Our scheduling simulations show that if all co-schedules containing multiple instances of the same program are removed, the average slowdown is decreased from 54% to 46% and that the worst case slowdown is decreased from 173% to 108%.
|
|
| 6. |
- de Blanche, Andreas, 1975-, et al.
(författare)
-
Initial Formulation of Why Disallowing Same Program Co-schedules Improves Performance
- 2017. - 1
-
Ingår i: Co-Scheduling of HPC Applications. - Netherlands : IOS Press. - 9781614997290 - 9781614997306 ; , s. 95-113
-
Bokkapitel (refereegranskat)abstract
- Co-scheduling processes on different cores in the same server might leadto excessive slowdowns if they use the same shared resource, like a memory bus. Ifpossible, processes with a high shared resource use should be allocated to differentserver nodes to avoid contention, thus avoiding slowdown. This article proposesthe more general principle that twins, i.e. several instances of the same program,should be allocated to different server nodes. The rational for this is that instancesof the same program use the same resources and they are more likely to be eitherlow or high resource users. High resource users should obviously not be combined,but a bit non-intuitively, it is also shown that low resource users should also notbe combined in order to not miss out on better scheduling opportunities. This isverified using both a probabilistic argument as well as experimentally using tenprograms from the NAS parallel benchmark suite running on two different systems.By using the simple rule of forbidding these terrible twins, the average slowdownis shown to decrease from 6.6% down to 5.9% for System A and from 9.5% to8.3% for System B. Furthermore, the worst case slowdown is lowered from 12.7%to 9.0% and 19.5% to 13% for systems A and B, respectively. Thus, indicating aconsiderable improvement despite the rule being program agnostic and having noinformation about any program’s resource usage or slowdown behavior.
|
|
| 7. |
- de Blanche, Andreas, et al.
(författare)
-
Terrible Twins : A Simple Scheme to Avoid Bad Co-Schedule
- 2016
-
Ingår i: Proceedings of the 1st COSH Workshop on Co-Scheduling of HPC Applications. - Munchen. ; , s. 1-6
-
Konferensbidrag (refereegranskat)abstract
- Co-scheduling processes on different cores in the same server might lead to excessive slowdowns if they use a shared resource,like the memory bus. If possible, processes with a high shared resource use should be allocated to different server nodes to avoid contention, thus avoiding slowdown.This paper introduces the simple scheme of avoiding to coschedule twins, i.e., several instances of the same program.The rational for this is that instances of the same program use the same resources and they are more likely to be either low or high resource users − high resource users should obviously not be combined, but a bit non-intuitively, it is also shown that low resource users should also not be combined in order to not miss out on better scheduling opportunities.This is verified using both a statistical argument as well as experimentally using ten programs from the NAS parallel benchmark suite. By using the simple rule of forbidding twins, the average slowdown is shown to decrease from 6.6% down to 5.9%, and the worst case slowdown is lowered from 12.7% to 9.0%, indicating a considerable improvement despite having no information about any programs' resource usage or slowdown behavior.
|
|
| 8. |
- Hjerpe, Elisabet, et al.
(författare)
-
Lymph node metastases as only qualifier for stage IV serous ovarian cancer confers longer survival than other sites of distant disease - a Swedish Gynecologic Cancer Group (SweGCG) study.
- 2018
-
Ingår i: Acta oncologica (Stockholm, Sweden). - : TAYLOR & FRANCIS LTD. - 1651-226X .- 0284-186X. ; 57:3, s. 331-337
-
Tidskriftsartikel (refereegranskat)abstract
- The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer.This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between 2009-2014. We compare overall survival (OS) in women with LN as only distant metastatic site to those with pleural metastases only and to patients with other/multiple stage IV manifestations. Cox regression models were used for uni- and multivariable estimations.Of 551stage IV cases, distant metastatic site was registered in 433. Median OS for women with LN (n=51) was 41.4 months, compared to 25.2 and 26.8 months for patients with pleural (n=195) or other/multiple (n=187) distant metastases (p=.0007). The corresponding five-year survival rates were 32, 11 and 22%, respectively. Multivariable analyzes confirmed shorter survival for women with pleural (HR 2.99, p=.001) or other/multiple distant sites (HR 2.67, p=.007), as compared to LN cases. LN only patients lived 9.1 months longer after primary than after interval surgery, but this difference was not significant (p=.245).Women with stage IV serous ovarian cancer having lymph nodes as only distant metastatic site live longer than other stage IV patients.
|
|
| 9. |
- Kool, Erik C., et al.
(författare)
-
A radio-detected type Ia supernova with helium-rich circumstellar material
- 2023
-
Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 617:7961, s. 477-482
-
Tidskriftsartikel (refereegranskat)abstract
- Type Ia supernovae (SNe Ia) are thermonuclear explosions of degenerate white dwarf stars destabilized by mass accretion from a companion star1, but the nature of their progenitors remains poorly understood. A way to discriminate between progenitor systems is through radio observations; a non-degenerate companion star is expected to lose material through winds2 or binary interaction3 before explosion, and the supernova ejecta crashing into this nearby circumstellar material should result in radio synchrotron emission. However, despite extensive efforts, no type Ia supernova (SN Ia) has ever been detected at radio wavelengths, which suggests a clean environment and a companion star that is itself a degenerate white dwarf star4,5. Here we report on the study of SN 2020eyj, a SN Ia showing helium-rich circumstellar material, as demonstrated by its spectral features, infrared emission and, for the first time in a SN Ia to our knowledge, a radio counterpart. On the basis of our modelling, we conclude that the circumstellar material probably originates from a single-degenerate binary system in which a white dwarf accretes material from a helium donor star, an often proposed formation channel for SNe Ia (refs. 6,7). We describe how comprehensive radio follow-up of SN 2020eyj-like SNe Ia can improve the constraints on their progenitor systems.
|
|
| 10. |
- Lindemann, Kristina, et al.
(författare)
-
Chemotherapy vs tamoxifen in platinum-resistant ovarian cancer: a phase III, randomised, multicentre trial (Ovaresist)
- 2017
-
Ingår i: British Journal of Cancer. - : NATURE PUBLISHING GROUP. - 0007-0920 .- 1532-1827. ; 116:4, s. 455-463
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Chemotherapy in platinum-resistant ovarian cancer (PROC) aims for palliation and prolonging of progression-free survival (PFS). This study compares Health-related Quality of Life (HRQoL) and efficacy between single-agent chemotherapy and tamoxifen in PROC. Methods: Patients with PROC were randomised (2 : 1) to chemotherapy (weekly paclitaxel 80 mg m(-2) or four weekly pegylated liposomal doxorubicin 40 mg m(-2)) or tamoxifen 40mg daily. The primary end point was HRQoL. Secondary end points were PFS by RECIST and overall survival (OS). Results: Between March 2002 and December 2007, 156 and 82 patients were randomised to chemotherapy and tamoxifen, respectively. In the chemotherapy arm, a significantly larger proportion of patients experienced a worsening in their social functioning. There was no difference in the proportion of patients experiencing improvement of gastrointestinal symptoms. Median PFS on tamoxifen was 8.3 weeks (95% CI, 8.0-10.4) compared with 12.7 weeks (95% CI, 9.0-16.3) on chemotherapy (HR, 1.54; 95% CI, 1.16-2.05; log-rank P = 0.003). There was no difference in OS between the treatment arms. Conclusions: Patients on chemotherapy had longer PFS but experienced more toxicity and poorer HRQoL compared with tamoxifen. Control over gastrointestinal symptoms was not better on chemotherapy. These data are important for patient counselling and highlight the need to incorporate HRQoL end points in studies of PROC.
|
|
| 11. |
- Rosenberg, Per, et al.
(författare)
-
Data quality in the Swedish Quality Register of Gynecologic Cancer - a Swedish Gynecologic Cancer Group (SweGCG) study
- 2018
-
Ingår i: Acta Oncologica. - : TAYLOR & FRANCIS LTD. - 0284-186X .- 1651-226X. ; 57:3, s. 346-353
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this study is to evaluate the quality of data on endometrial (EC) and ovarian, fallopian tube, peritoneal, abdominal or pelvic cancers (OC) registered in the Swedish Quality Register of Gynecologic Cancer (SQRGC).Method: A random sample of 500 patients was identified in the SQRGC and their medical charts were reviewed for re-abstraction of 31 selected core variables by an independent validator. The data in the SQRGC and the re-abstracted data were compared. The data were collected from 25 hospitals evenly distributed throughout Sweden. The main outcomes were comparability, timeliness, completeness and validity. Coverage was compared with the National Cancer Register (NCR). Timeliness was defined as the speed of registration i.e. when patients were registered in the SQRGC relative to date of diagnosis. Internationally accepted coding systems for stage, grading and histologic type were used ensuring a high degree of comparability. Correlations were estimated using Pearson’s correlation coefficient and Cohen´s kappa coefficient.Results: The completeness was 95%. The timeliness was 88–91% within 12 months of diagnosis. The median degree of agreement between re-abstracted data and data in the SQRGC was 82.1%, with a median kappa value of 0.73 for ordinate variables and a median Pearson’s correlation coefficient of 0.96. The agreements for the type of surgery were 76% (95% CI 70–81%; kappa 0.49) and type of primary treatment 90% (95% CI 87–94%; kappa 0.85) in OC and in EC 88% (95% CI 84–93%; kappa 0.84). The agreements for the FIGO stage were in OC and EC 74% (95% CI 68–80%; kappa 0.69) and 87% (95% CI 82–91%; kappa 0.79), respectively.Conclusions: The data in the Swedish Quality Register for Gynecologic Cancer are of adequate quality in order to be used as a basis for research and to evaluate possible differences in treatment, lead times and treatment results.
|
|
