| 1. |
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| 2. |
- Cabrera, C., et al.
(författare)
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Relationship between iron deficiency and expression of genes involved in iron metabolism in human myocardium and skeletal muscle
- 2023
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Ingår i: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 379, s. 82-88
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Tidskriftsartikel (refereegranskat)abstract
- Background: Iron deficiency (ID) is associated with adverse prognosis in patients with heart failure. This study aims to investigate the relationship between ID and expression of genes involved in iron metabolism in human myocardium and skeletal muscle, focusing on Transferrin 1 receptor (TfR1), the main pathway of cellular iron uptake.Methods: Patients undergoing elective CABG were assessed prior to surgery with echocardiography and serum iron parameters. Core needle biopsies were collected from the left and right ventricle (LV, RV), the right atrium and intercostal skeletal muscle (SM). Gene expression analyses were done by mRNA sequencing.Results: Of 69 patients (median age 69 years, 91% men), 28% had ID. 26% had HFrEF, 25% had HFpEF phys-iology according to echocardiographic findings and NT-proBNP levels, and 49% had normal LV function. The expression of TfR1 was increased in patients with ID compared to patients without ID in ventricular tissue (p = 0.04) and in intercostal SM (p = 0.01). The increase in TfR1 expression in LV and RV was more pronounced when analysing patients with absolute ID (S-Ferritin<100 mu g/L). Analysing the correlation between various iron pa-rameters, S-Ferritin levels showed the strongest correlation with TfR1 expression. There was no correlation with NT-proBNP levels and no difference in TfR1 expression between different HF phenotypes.Conclusions: In patients undergoing elective CABG we found an association between ID and increased TfR1 expression in myocardium regardless of LV function, indicating physiologically upregulated TfR1 expression in the presence of ID to restore intracellular iron needs.
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| 3. |
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| 4. |
- Cacciani, P., et al.
(författare)
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Lifetime measurements of the e1II, v = 0 and v = 1 states of12C16O, 13C16O, and13C18O
- 1998
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Ingår i: Astrophysical Journal. - 0004-637X. ; 499:2 PART II, s. 223-226
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Tidskriftsartikel (refereegranskat)abstract
- In a laboratory investigation using tunable picosecond lasers in a pump-probe configuration, lifetimes of the E 1u, v = 0 and v = 1 states of CO are experimentally determined. For E 'D, v = 1, the lifetime is found to vary significantly for the isotopomers. Combining the data with existing oscillator strengths, predissociation probabilities within the range of 93.6%-98.6% result for 12C16O, 13C16O, and 13C18O in the case of the E 1u, v = I state, which is the state that predominantly influences the isotopic fractionation of CO in interstellar clouds.
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| 5. |
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| 6. |
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| 7. |
- Cacciani, P, et al.
(författare)
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Lifetime measurements of the E (1)Pi, upsilon=0 and upsilon=1 states of (CO)-C-12-O-16, (CO)-C-13-O-16, and (CO)-C-13-O-18
- 1998
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X. ; 499
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Tidskriftsartikel (refereegranskat)abstract
- In a laboratory investigation using tunable picosecond lasers in a pump-probe configuration, lifetimes of the E (II)-I-1, v = O and v = 1 states of CO are experimentally determined. For E (II)-I-1, v = 1, the lifetime is found to vary significantly for the isotopomers. Combining the data with existing oscillator strengths, predissociation probabilities within the range of 93.6%-98.64% result for (CO)-C-12-O-16, (CO)-C-13-O-16, and (CO)-C-13-O-18 in, the case of the E (II)-I-1, v=1 state, which is the state that predominantly influences the isotopic fractionation of CO in interstellar clouds.
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| 8. |
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| 9. |
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| 10. |
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| 11. |
- Lynga, C, et al.
(författare)
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Temporal coherence of high-order harmonics
- 1999
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 60:6, s. 4823-4830
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Tidskriftsartikel (refereegranskat)abstract
- Systematic studies of the temporal coherence properties of high-order harmonic radiation are presented. These complement our previous investigations [Bellini et at, Phys. Rev. Lett. 81, 297 (1998)], where we showed the separation of the far-field pattern of high-order harmonics into two distinct spatial regions with different coherence times. Here we show how the coherence time of the inner and outer regions changes as a function of the harmonic order, the laser intensity, and the focusing conditions. Good agreement with the predictions of the semiclassical model of harmonic generation is obtained. [S1050-2947(99)10312-3].
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| 12. |
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| 13. |
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| 14. |
- Sikstrom, C. M, et al.
(författare)
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New Zr II oscillator strengths and the zirconium conflict in the HgMn star chi Lupi
- 1999
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Ingår i: Astronomy & Astrophysics. - 0004-6361. ; 343:1, s. 297-302
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes on the sub-nanosecond scale for the levels v(2)D(3/2), v(2)F(3/2) and v(2)F(5/2) in the 4d5s5p configuration in Zr II have been measured, using the method of laser-induced fluorescence. Combined with branching fractions obtained with the Lund Ultraviolet (UV) Fourier Transform Spectrometer (FTS), experimental oscillator strengths have been derived. From Hubble Space Telescope/Goddard High-Resolution Spectrograph spectra, the zirconium abundance in the HgMn star chi Lupi has been determined from Zr II and Zr III lines. More than an order of magnitude difference in the Zr II abundance has been derived from these ionization stages. The difference is much too large to be explained by uncertainties in the oscillator strengths. Possible explanations of this difference have to be found in the stellar models, such as the influence of non-LTE or diffusion.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Zerne, R, et al.
(författare)
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Phase-locked high-order harmonic sources
- 1997
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Ingår i: Physical Review Letters. - 1079-7114. ; 79:6, s. 1006-1009
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate that two harmonic sources generated independently in a xenon gas jet using the same picosecond Nd:YAG laser are locked in phase. The experiment is performed by separating a laser beam into two parallel beams focused at different locations under the nozzle of a gas jet, and therefore producing two independent sources of harmonic radiation, and studying the pattern obtained in the far field when the radiations from these sources interfere. A high and robust fringe visibility is obtained.
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| 19. |
- Bellini, M, et al.
(författare)
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Temporal coherence of ultrashort high-order harmonic pulses
- 1998
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Ingår i: Physical Review Letters. - 1079-7114. ; 81:2, s. 297-300
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Tidskriftsartikel (refereegranskat)abstract
- We have studied the temporal coherence of high-order harmonics (up to the 15th order) produced by focusing 100 fs laser pulses into an argon gas jet. We measure the visibility of the interference fringes, produced when two spatially separated harmonic sources interfere in the far field, as a function of the time delay between the two sources. In general, we find long coherence times, comparable to the expected pulse durations of the harmonics. For some of the harmonics, the interference pattern exhibits two regions, with significantly different coherence times. These results are interpreted in terms of different electronic trajectories contributing to harmonic generation. [S0031-9007(98)05569-7].
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| 20. |
- Biemont, E, et al.
(författare)
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Radiative lifetimes, branching fractions and transition probabilities in Ge I - solar implications
- 1999
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 1365-2966 .- 0035-8711. ; 303:4, s. 721-726
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Tidskriftsartikel (refereegranskat)abstract
- New radiative lifetimes have been measured for the 5s (3)P(0,1,2)degrees and 5s (1)P(1)degrees levels of Ge I using a laser-produced plasma subject to selective laser excitation. A diffraction grating based emission spectrometer of moderately high resolution has been used to remeasure the branching ratios of the 4p-5s depopulating transitions. The oscillator strengths of astrophysical interest, which have been derived from these new data, are compared with theoretical values calculated within a pseudo-relativistic Hartree-Fock approach. The new set of f-values has been compared with the few results available in the literature, which are generally characterized by a large scatter and a low accuracy. The solar photospheric abundance of germanium deduced from the new atomic data of the present work is A(Ge) = 3.58 +/- 0.05, on the usual logarithmic scale, in agreement with the meteoritic value.
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| 21. |
- Cabrera, Carin C., et al.
(författare)
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Increased iron absorption in patients with chronic heart failure and iron deficiency
- 2020
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Ingår i: Journal of Cardiac Failure. - : Elsevier BV. - 1071-9164 .- 1532-8414. ; 26:5, s. 440-443
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Tidskriftsartikel (refereegranskat)abstract
- Background: Iron deficiency (ID) is common in patients with chronic heart failure (CHF), but the underlying causes are not fully understood. We investigated whether ID is associated with decreased iron absorption in patients with CHF.Methods and Results: We performed an oral iron-absorption test in 30 patients and 12 controls. The patients had CHF with reduced (n = 15) or preserved (n = 15) ejection fraction and ID, defined as s- ferritin < 100 mu g/L, or s-ferritin 100-299 mu g/L and transferrin saturation < 20%. The controls had no HF or ID and were of similar age and gender. Blood samples were taken before and 2 hours after ingestion of 100 mg ferroglycin sulphate. The primary endpoint was the delta plasma iron at 2 hours. The delta plasma iron was higher in the group with HF than in the control group (median increase 83.8 [61.5;128.5] mu g/dL in HF vs 47.5 [ 30.7;61.5] mu g/dL in controls, P = 0.001), indicating increased iron absorption. There was no significant difference between the groups with preserved or reduced ejection fraction (P = 0.46).Conclusion: We found increased iron absorption in patients with CHF and ID compared to controls without ID and HF, indicating that reduced iron absorption is not a primary cause of the high prevalence of ID in patients with CHF.
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| 22. |
- Cacciani, P, et al.
(författare)
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Isotope dependent predissociation in the C-1 Sigma(+) ,v=0 and v=1 states of CO
- 2001
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Ingår i: European Physical Journal D. Atomic, Molecular, Optical and Plasma Physics. - : Springer Science and Business Media LLC. - 1434-6060. ; 15:1, s. 47-56
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Tidskriftsartikel (refereegranskat)abstract
- Rotationally resolved spectral lines in the C-X(1,0) band of carbon monoxide are investigated under high resolution using a coherent vacuum ultraviolet laser source, continuously tunable near 107 nm. Transition frequencies are determined by calibrating against a reference standard of iodine lines, recorded with saturation spectroscopy in the visible range, yielding an absolute accuracy of 0.003 cm(-1) in the vacuum ultraviolet. Improved molecular constants for the excited state are clarified and Mo effects of perturbation are found at the present level of accuracy. Line broadening measurements result in information on the excited state lifetime of the (CC)-C-1 Sigma (+),v = 1 state fur five natural isotopomers: of cal bon monoxide: tau((CO)-C-12-O-17) = 280 ps, tau((CO)-C-12-O-18) = 210 ps. tau((CO)-C-13-O-16) = 295 ps, tau((OO)-O-13-O-17) = 160 ps and tau((CO)-C-13-O-18) = 150 Ps. Within the accuracy of the present measurements: Ilo effects: of J-dependent lifetimes: were observed, for neither of the isotopomers. In addition direct time domain measurements: of the lifetime of the C(1)Sigma (+),v = 0 and v = 1 states of the main isotopomer are performed ill a pump-mode experiment using a picosecond VUV-laser, yielding tau((CO)-C-12-O-16) = 1780 ps for v = 0 and tau((CC)-C-12-C-16)) = 625 ps for v = 1. For C(1)Sigma (+), v = 0 in (CO)-C-12-O-16 and (CO)-C-13-O-16 the same lifetime is found; this lifetime matches experimental values of the oscillator strength and hence supports previous results showing pure radiative decay ill this state; the error margins however do not exclude some low level of predissociation. The measurements indicate that the C(1)Sigma (+),v = 0 state of the (CO)-C-13-O-18 isotopomer is predissociated with an estimated yield of 17% (i.e. above the level of predissociation for (CO)-C-12-O-16.) From the combined data predissociation yields: upon excitation of the C(1)Sigma (+),v = 1 state are derived, lying in the range 0.84-0.91. for the five less abundant isotopomers; for the main (CO)-C-12-O-16 isotopomer a strongly deviating predissociation yield of 0.65 is deduced.
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| 23. |
- Descamps, D, et al.
(författare)
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Extreme ultraviolet interferometry measurements with high-order harmonics
- 2000
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Ingår i: Optics Letters. - 0146-9592. ; 25:2, s. 135-137
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate that high-order harmonics generated by short, intense laser pulses in gases provide an interesting radiation source for extreme ultraviolet interferometry, since they are tunable, coherent, of short pulse duration, and simple to manipulate. Harmonics from the 9th to the 15th are used to measure the thickness of an aluminum layer. The 11th harmonic is used to determine the spatial distribution of the electron density of a plasma produced by a 300-ps laser. Electronic densities higher than 2-10(20) electrons/cm(3) are measured. (C) 2000 Optical Society of America. OCIS codes: 190.0190, 190.4160, 190.7110, 120.3180, 140.7240, 350.4500.
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| 24. |
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| 25. |
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| 26. |
- Johansson, Allan, et al.
(författare)
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Two-color pump-probe experiments in helium using high-order harmonics
- 2003
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Ingår i: European Physical Journal D. Atomic, Molecular, Optical and Plasma Physics. - : Springer Science and Business Media LLC. - 1434-6060 .- 1434-6079. ; 22:1, s. 3-11
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Tidskriftsartikel (refereegranskat)abstract
- A pump-probe technique has been applied for measuring the lifetimes and absolute photoionization cross-sections of excited He states. The 1s2p P-1 and 1s3p P-1 states of He are excited by using the 13th and the 14th harmonic, respectively, of a tunable 70 ps dye laser generated in a Kr gas jet. The states are ionized after a varying time delay, by absorption of probe photons with energies between 1.6 and 4.5 eV. Lifetimes of tau(1s2p) = 0.57 ns and tau(1s3p) = 1.76 ns are determined with a precision of about 15%. A significant enhancement of the number of ions present in the lifetime curves at zero time delay for pressures above 6 x 10(-5) mbar is attributed to direct two-photon ionization of He in combination with AC Stark broadening of the excited state and absorption of the XUV light in the medium. Absolute photoionization cross-sections from the He 1s2p P-1 and He 1s3p P-1 states in the threshold region are determined by measuring the saturation of the ionization process with a precision of similar to 25%. In addition, the variation of the relative orientation between the polarization vectors of the pump and probe beams enables the determination of partial photoionization cross-sections.
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| 27. |
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| 28. |
- Lynga, C, et al.
(författare)
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A laser system providing tunable, narrow-band radiation from 35 nm to 2 mu m
- 2001
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Ingår i: Applied Physics B. - : Springer Science and Business Media LLC. - 0946-2171 .- 1432-0649. ; 72:8, s. 913-920
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Tidskriftsartikel (refereegranskat)abstract
- We describe a laser system that readily provides radiation tunable from 2 mum in the infra-red to 35 nm in the extreme ultraviolet spectral range. The broad spectral range is covered through a range of non-linear processes such as Raman shifting and high-order harmonic generation. Pulses with duration of tens of picoseconds are obtained. The relative bandwidth of the radiation is delta lambda/lambda = 10(-4), comparable with what can be achieved by using high-resolution monochromators at state-of-the-art synchrotron beamlines. We discuss different methods for characterising the radiation in this wide wavelength regime. We also discuss the capabilities of the system from the measured parameters.
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| 29. |
- Lynga, C, et al.
(författare)
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High-order harmonic generation in molecular gases
- 1996
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Ingår i: Journal of Physics B: Atomic, Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 29:14, s. 3293-3302
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Tidskriftsartikel (refereegranskat)abstract
- We present an experimental study of harmonic generation in molecular gases, using the fundamental (800 nm) and the second harmonic (400 nm) of a 150 fs titanium - sapphire laser at an intensity of ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img1.gif] . We compare the conversion efficiency and the maximum energy obtained in different species: rare gases (Ar, Xe), diatomic molecules ( ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img2.gif] , ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img3.gif] , ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img4.gif] , CO) and polyatomic molecules ( ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img5.gif] , ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img2.gif] O, ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img7.gif] , ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img8.gif] , ##IMG## [http://ej.iop.org/images/0953-4075/29/14/032/img9.gif] ). The harmonic spectra from molecular gases are very similar to those obtained in the atomic gases, with a plateau and a cutoff whose location is strongly correlated to the value of the ionization potential. The conversion efficiency is not higher than that of the rare gases.
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