| 1. |
- Heijnsdijk, Eveline A M, et al.
(författare)
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Quality-of-life effects of prostate-specific antigen screening.
- 2012
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Ingår i: The New England journal of medicine. - 1533-4406. ; 367:7, s. 595-605
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Tidskriftsartikel (refereegranskat)abstract
- After 11 years of follow-up, the European Randomized Study of Screening for Prostate Cancer (ERSPC) reported a 29% reduction in prostate-cancer mortality among men who underwent screening for prostate-specific antigen (PSA) levels. However, the extent to which harms to quality of life resulting from overdiagnosis and treatment counterbalance this benefit is uncertain.
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| 2. |
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| 3. |
- Rajan-Sithamparanadarajah, R, et al.
(författare)
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Patterns of dermal exposure to hazardous substances in European union workplaces.
- 2004
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Ingår i: Annals of Occupational Hygiene. - : Oxford University Press (OUP). - 0003-4878 .- 1475-3162. ; 48:3, s. 285-97
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Tidskriftsartikel (refereegranskat)abstract
- Workplace dermal exposure assessment is a complex task that aims to understand the dynamic interaction between the skin and the hazardous substances present in the surrounding environment. A European project known as RISKOFDERM gathered dermal exposure data in 85 workplaces (industrial and other types) in five countries in Europe. In order to optimize data collection and to develop a representative picture of dermal exposure, scenarios (tasks made up of a series of activities) were grouped together into dermal exposure operation units (DEOs). The allocation of scenarios to relevant DEOs was achieved on the basis of similarities of exposure routes, tasks and professional judgement. Sampling and quantification procedures were based on the approaches recommended by the OECD protocol. The laboratories involved in the analysis of the samples participated in quality assurance programmes. This exercise resulted in 419 body measurements and 437 measurements on hands expressed in terms of formulation (product) in use. Exposures for a given scenario varied by several orders of magnitude. The extent and patterns of exposure were found to be dependent on various exposure determinants, including inter- and intra-scenario variations. Hands were found to be the most contaminated parts of the body. Exposure patterns for liquid and solid contaminants were different. On the basis of the analysis of the data presented here, the averaged results (median and 95th percentile) for a given DEO unit should not be used as a representative measure of dermal exposure for all scenarios within that DEO without taking the exposure determinants into account. However, the data could be used to develop an exposure matrix (indicative exposure distributions) for different types of scenario and workplace, using determinants of exposure and a Bayesian approach to integrating expert opinion.
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| 4. |
- Harri, A.-M., et al.
(författare)
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Mars Science Laboratory relative humidity observations: Initial results
- 2014
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Ingår i: Journal of Geophysical Research - Planets. - 2169-9097 .- 2169-9100. ; 119:9, s. 2132-2147
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Tidskriftsartikel (refereegranskat)abstract
- The Mars Science Laboratory (MSL) made a successful landing at Gale crater early August 2012. MSL has an environmental instrument package called the Rover Environmental Monitoring Station (REMS) as a part of its scientific payload. REMS comprises instrumentation for the observation of atmospheric pressure, temperature of the air, ground temperature, wind speed and direction, relative humidity (REMS-H), and UV measurements. We concentrate on describing the REMS-H measurement performance and initial observations during the first 100 MSL sols as well as constraining the REMS-H results by comparing them with earlier observations and modeling results. The REMS-H device is based on polymeric capacitive humidity sensors developed by Vaisala Inc., and it makes use of transducer electronics section placed in the vicinity of the three humidity sensor heads. The humidity device is mounted on the REMS boom providing ventilation with the ambient atmosphere through a filter protecting the device from airborne dust. The final relative humidity results appear to be convincing and are aligned with earlier indirect observations of the total atmospheric precipitable water content. The water mixing ratio in the atmospheric surface layer appears to vary between 30 and 75 ppm. When assuming uniform mixing, the precipitable water content of the atmosphere is ranging from a few to six precipitable micrometers.
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| 5. |
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| 6. |
- Chen, Chiu-Yu, et al.
(författare)
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Blood flow reprograms lymphatic vessels to blood vessels.
- 2012
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Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 122:6
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Tidskriftsartikel (refereegranskat)abstract
- Human vascular malformations cause disease as a result of changes in blood flow and vascular hemodynamic forces. Although the genetic mutations that underlie the formation of many human vascular malformations are known, the extent to which abnormal blood flow can subsequently influence the vascular genetic program and natural history is not. Loss of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) resulted in a vascular malformation that directed blood flow through mesenteric lymphatic vessels after birth in mice. Mesenteric vessels in the position of the congenital lymphatic in mature Slp76-null mice lacked lymphatic identity and expressed a marker of blood vessel identity. Genetic lineage tracing demonstrated that this change in vessel identity was the result of lymphatic endothelial cell reprogramming rather than replacement by blood endothelial cells. Exposure of lymphatic vessels to blood in the absence of significant flow did not alter vessel identity in vivo, but lymphatic endothelial cells exposed to similar levels of shear stress ex vivo rapidly lost expression of PROX1, a lymphatic fate-specifying transcription factor. These findings reveal that blood flow can convert lymphatic vessels to blood vessels, demonstrating that hemodynamic forces may reprogram endothelial and vessel identity in cardiovascular diseases associated with abnormal flow.
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| 7. |
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| 8. |
- Lepäntalo, M., et al.
(författare)
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PTFE bypass or thrupass for superficial femoral artery occlusion? : A randomised controlled trial
- 2009
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Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier BV. - 1078-5884 .- 1532-2165. ; 37:5, s. 578-584
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Tidskriftsartikel (refereegranskat)abstract
- Early results of a thrupass endograft in the treatment of femoral lesions are promising. Less morbidity and better cost-effectiveness are suggested to be achieved in the treatment of chronic lower limb ischaemia with endovascular treatment compared to surgical treatment. PATIENTS AND METHODS: This randomised multicentre trial aimed to enroll a group of 60+60 patients for the treatment of 5-25-cm occlusions of superficial femoral artery (SFA) to be followed up for 3 years. Patients were treated either with endoluminal PTFE thrupass (WL Gore & Ass) or with surgical polytetrafluoroethylene (PTFE) bypass to proximal popliteal artery. Primary patency at 3 years was scheduled to be the primary end-point and secondary patency, functional success, costs and quality of life the secondary end-points. RESULTS: A sample of 100 consecutive SFA occlusions in one of the centres revealed that only 4% of the lesions were amenable for the study. The trial was prematurely terminated due to the results of an interim analysis at the time when 44 patients were recruited: the 1-year primary patency (excluding technical failures) was 48% for thrupass and 95% for bypass (p=0.02). The patency difference in favour of surgical bypass over endovascular thrupass was also sustained after completion of 1-year follow-up, the primary patencies being 46% and 84% at 1 year with grossly equilinear life-table curves thereafter (p=0.18), respectively. The corresponding secondary patencies were 63% and 100% (p=0.05) when excluding technical failures and 58% and 100% (p=0.02) according to intention-to-treat analysis. Secondary outcomes were thus not analysed. CONCLUSION: Treatment of SFA occlusions (TASC IIB and C or Imelda Ia and II) should be done by PTFE bypass rather than by PTFE thrupass, as thrupass is connected with worse early outcome. These results represent only a small category of femoral disease.
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| 9. |
- Nordman, M., et al.
(författare)
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Crustal loading in vertical GPS time series in Fennoscandia
- 2009
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Ingår i: Journal of Geodynamics. - : Elsevier BV. - 0264-3707. ; 48:3-5, s. 144-150
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Tidskriftsartikel (refereegranskat)abstract
- We compare time series of vertical position from GPS with modelled vertical deformation caused by variation in continental water storage, variation in the level of the Baltic Sea, and variation in atmospheric pressure. Monthly time series are used. The effect of continental water storage was calculated from three different global models. The effect of non-tidal variation in Baltic Sea level was calculated using tide gauge observations along the coasts. Atmospheric loading was computed from a numerical weather model. The loading time series are then compared with three different GPS time series at seven stations in Fennoscandia. A more detailed analysis is computed at three coastal stations. When the monthly GPS time series are corrected using the load models, their root-mean-square scatter shows an improvement between 40 and 0%, depending on the site and on the GPS solution. The modelled load effect shows a markedly seasonal pattern of 15 mm peak-to-peak, of which the uncorrected GPS time series reproduce between 60 and 0%.
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| 10. |
- Rouhani, Sherin J., et al.
(författare)
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Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction
- 2015
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules, suggesting they might also tolerize CD4 T cells. We demonstrate that when beta-galactosidase (beta-gal) is expressed in LECs, beta-gal-specific CD8 Tcells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways. In contrast, LECs do not present endogenous b-gal in the context of MHC-II molecules to b-gal-specific CD4 T cells. Lack of presentation is independent of antigen localization, as membrane-bound haemagglutinin and I-Ea are also not presented by MHC-II molecules. LECs express invariant chain and cathepsin L, but not H2-M, suggesting that they cannot load endogenous antigenic peptides onto MHC-II molecules. Importantly, LECs transfer b-gal to dendritic cells, which subsequently present it to induce CD4 T-cell anergy. Therefore, LECs serve as an antigen reservoir for CD4 T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 T-cell tolerance via LAG-3.
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| 11. |
- Saari, Ulla A., et al.
(författare)
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Designing green marketing across industries : A conceptual framework and implications for consumers and transdisciplinary research
- 2018
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Ingår i: Handbook of sustainability science and research. - Cham : Springer. - 9783319630069 - 9783319630076 ; , s. 581-596
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Bokkapitel (refereegranskat)abstract
- Understanding what marketing messages trigger sustainable consumer behavior is one of the key issues for companies to be able to design effective green marketing. The goal of this paper is to present a conceptual framework for a green marketing approach that includes product, industry, production processes, and supply chain specific considerations to be utilized in the design of green product marketing for the mass markets. Based on a literature review, we have created a conceptual framework with industry-specific aspects on the basis of unique features in seven industrial sectors that are of relevance to the personal needs of consumers from an environmental perspective, but are focusing on the product-specific aspects of the marketed products. The originality of this study lies in the proposition that green marketing should use the actual product features as a starting point and not focus only on green consumers. The greenness of a product should be an additional dimension that adds to the competitiveness of the product when compared to conventional products. Theoretically, we propose that a transdisciplinary approach that integrates sustainable supply chain management perspectives to green marketing would benefit companies designing green marketing approaches and consumers making green product choices.
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| 12. |
- Saari, Ulla A., et al.
(författare)
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Eco-friendly brands to drive sustainable development : Replication and extension of the brand experience scale in a cross-national context
- 2017
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 9:7
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study is to explore how consumers perceive eco-friendliness in their brand experiences and how this can be measured cross-nationally. This is a replication-extension study based on an existing brand experience scale. Data were collected in India and Finland from smartphone users (N = 1008). The fitness of the brand experience model is validated cross-nationally with structural equation modeling. The empirical data consisting of consumers' responses on the Apple, Samsung, and Nokia brands confirm that there is a unique dimension of eco-friendliness in the general brand experiences of consumers, and it is generalizable cross-nationally in India and Finland. The study presents a consumer-focused measure of sustainable development that could be used to track how consumers perceive the eco-friendliness of brands. The paper links consumer experiences that guide sustainable consumption behavior to the macro-level management of sustainable development. This paper extends previous research on brand experience measurement by testing cross-nationally a scale including a dimension for measuring eco-friendliness. The brand experience measurement scale could aid companies in tracking the success of their sustainable development initiatives on the brand level.
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| 13. |
- Saari, Ulla A., et al.
(författare)
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How consumers’ respect for nature and environmental self-assets influence their car brand experiences
- 2020
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Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786. ; 261
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Tidskriftsartikel (refereegranskat)abstract
- This paper provides a novel perspective on sustainability research by exploring how two pro-environmental characteristics of consumers – respect for nature and environmental self-assets – influence their brand experiences. The study uses survey data collected on a car brand that incorporated eco-friendly advances. The results show that respect for nature has an impact on how respondents experience the eco-friendliness of brands and that eco-friendly brand experiences in turn influence general brand experiences. The findings also suggest that the effects of the two pro-environmental characteristics depend on the education level of the consumer: eco-friendly brand experiences of highly educated consumers are affected by their respect for nature, whereas those of consumers with lower education levels are affected by environmental self-assets.
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| 14. |
- Saari, Ulla A., et al.
(författare)
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Is eco-friendliness driving customer product choice in technology markets?
- 2016
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Konferensbidrag (refereegranskat)abstract
- The goal of this study is to examine how eco-friendliness in the brand experience impacts product selection, and how product selection induces green brand loyalty among customers and consumers. A conceptual model is tested with empirical data collected with a web survey on mobile phone brands. The findings of this research indicate that eco-friendliness in the brand experience influences positively product selection and green brand loyalty for some global brands. Thefindings also point out that technology firms should seriously consider their sustainability and eco-friendliness strategies in their technology commercialization activities.
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| 15. |
- Singhal, Dhruv, et al.
(författare)
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Mapping the lymphatic system across body scales and expertise domains : A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium
- 2023
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Ingår i: Frontiers in Physiology. - : Frontiers Media S.A.. - 1664-042X. ; 14
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Forskningsöversikt (refereegranskat)abstract
- Enhancing our understanding of lymphatic anatomy from the microscopic to the anatomical scale is essential to discern how the structure and function of the lymphatic system interacts with different tissues and organs within the body and contributes to health and disease. The knowledge of molecular aspects of the lymphatic network is fundamental to understand the mechanisms of disease progression and prevention. Recent advances in mapping components of the lymphatic system using state of the art single cell technologies, the identification of novel biomarkers, new clinical imaging efforts, and computational tools which attempt to identify connections between these diverse technologies hold the potential to catalyze new strategies to address lymphatic diseases such as lymphedema and lipedema. This manuscript summarizes current knowledge of the lymphatic system and identifies prevailing challenges and opportunities to advance the field of lymphatic research as discussed by the experts in the workshop.
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| 16. |
- Uebbing, Severin, et al.
(författare)
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Divergence in gene expression within and between two closely related flycatcher species
- 2016
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Ingår i: Molecular Ecology. - : Wiley. - 0962-1083 .- 1365-294X. ; 25:9, s. 2015-2028
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Tidskriftsartikel (refereegranskat)abstract
- Relatively little is known about the character of gene expression evolution as species diverge. It is for instance unclear if gene expression generally evolves in a clock-like manner (by stabilizing selection or neutral evolution) or if there are frequent episodes of directional selection. To gain insights into the evolutionary divergence of gene expression, we sequenced and compared the transcriptomes of multiple organs from population samples of collared (Ficedula albicollis) and pied flycatchers (F. hypoleuca), two species which diverged less than one million years ago. Ordination analysis separated samples by organ rather than by species. Organs differed in their degrees of expression variance within species and expression divergence between species. Variance was negatively correlated with expression breadth and protein interactivity, suggesting that pleiotropic constraints reduce gene expression variance within species. Variance was correlated with between-species divergence, consistent with a pattern expected from stabilizing selection and neutral evolution. Using an expression PST approach, we identified genes differentially expressed between species and found 16 genes uniquely expressed in one of the species. For one of these, DPP7, uniquely expressed in collared flycatcher, the absence of expression in pied flycatcher could be associated with a ≈ 20 kb deletion including 11 out of 13 exons. This study of a young vertebrate speciation model system expands our knowledge of how gene expression evolves as natural populations become reproductively isolated.
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| 17. |
- Aagaard, Annabeth, et al.
(författare)
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Mapping the types of business experimentation in creating sustainable value : A case study of cleantech start-ups
- 2021
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Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786. ; 279
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Tidskriftsartikel (refereegranskat)abstract
- In this study, business experimentation for sustainable value creation is explored through seven cleantech start-ups by applying the systemic combining approach. The findings reveal novel descriptions of six different business experimentation types. The study also advances our theoretical understanding of how the specific roles of learning, signaling, and convincing dominate each of the experimentation types differently and how each type of business experimentation has a distinct purpose. Furthermore, our findings propose how business experimentation types can be applied as a continuum as part of the cleantech start-ups’ sustainable value creation process. Hence, our study contributes theoretically to our understanding of business experimentation for sustainable value creation and how the different types are applied in cleantech start-ups. We conclude our treatise with managerial implications and outline fruitful future research avenues.
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| 18. |
- Aho, Sonja, et al.
(författare)
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Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study)
- 2024
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 16:5
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Tidskriftsartikel (refereegranskat)abstract
- Simple Summary The location of the primary tumor in the right colon, left colon, or rectum affects the efficacy of biological drugs used in the treatment of metastatic colorectal cancer, but how? We examined how the primary tumor location affects disease characteristics, treatability, quality of life, and outcome in a real-life study population of 1080 Finnish patients in the RAXO study. The primary tumor location correlates with the location of metastases, the frequency of gene mutations, how often metastases can be operated upon, long-term survival after curative surgery or palliative chemotherapy, and the quality of life during the disease trajectory. The primary tumor location is a helpful surrogate for clinicians working with metastatic colorectal cancer patients in estimating the clinical course of the disease. This study cannot identify the reasons for the associations, i.e., whether it is the primary location per se, the different mutations, or other reasons.Abstract The primary tumor location (PTL) is associated with the phenotype, metastatic sites, mutations, and outcomes of metastatic colorectal cancer (mCRC) patients, but this has mostly been studied according to sidedness (right vs. left sided). We studied right colon vs. left colon vs. rectal PTL in a real-life study population (n = 1080). Health-related quality of life (HRQoL) was assessed multi-cross-sectionally with QLQ-C30, QLQ-CR29, EQ-5D, and 15D. A chi-square, Kaplan-Meier, and Cox regression were used to compare the groups. The PTL was in the right colon in 310 patients (29%), the left colon in 396 patients (37%), and the rectum in 375 patients (35%). The PTL was associated with distinct differences in metastatic sites during the disease trajectory. The resectability, conversion, and resection rates were lowest in the right colon, followed by the rectum, and were highest in the left colon. Overall survival was shortest for right colon compared with left colon or rectal PTL (median 21 vs. 35 vs. 36 months), with the same trends after metastasectomy or systemic therapy only. PTL also remained statistically significant in a multivariable model. The distribution of symptoms varied according to PTL, especially between the right colon (with general symptoms of metastases) and rectal PTL (with sexual- and bowel-related symptoms). mCRC, according to PTL, behaves differently regarding metastatic sites, resectability of the metastases, outcomes of treatment, and HRQoL.
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| 19. |
- Ahokangas, E., et al.
(författare)
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Seismic Imaging of Esker Sediments within the Satakunta Sandstone Depression in Köyliö, SW Finland
- 2016
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Konferensbidrag (refereegranskat)abstract
- The Satakunta sandstone depression infilled by the Pori-Koski interlobate esker sediments hosts a major high-quality groundwater reservoir in Köyliö, SW Finland. These up to 100 m thick sediments were delineated for the first time down to bedrock level by high-resolution reflection seismic method using a newly developed landstreamer consisting of 80-3C MEMs (micro electro mechanical) broadband sensors together with 50 wireless recorders connected to 10 Hz geophones to obtain greater depth penetrations. The 5-day survey resulted in about 5 km long seismic data (2-4 m receiver and shot spacing) and two profiles. Indications of crystalline basement are lacking in the tomography sections, implying that the (fractured) Rapakivi granite area extends further southeast than expected. The sandstone contact position was also ca. 500 m further to the east than expected. The sandstone depression and infilling esker sediments and the bedrock level were shown with good accuracy in both tomographic model and the reflection section. The hydraulically conductive esker core does not follow the sandstone contact and is underlain by older sediments. This case study illustrates the capability of high-resolution seismic surveys with the parameters used in this study for hydrogeological investigations and in particular in thick glacial sediments.
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| 20. |
- Bianchi, Roberta, et al.
(författare)
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A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research
- 2015
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- The lymphatic vascular system plays an active role in immune cell trafficking, inflammation and cancer spread. In order to provide an in vivo tool to improve our understanding of lymphatic vessel function in physiological and pathological conditions, we generated and characterized a tdTomato reporter mouse and crossed it with a mouse line expressing Cre recombinase under the control of the lymphatic specific promoter Prox1 in an inducible fashion. We found that the tdTomato fluorescent signal recapitulates the expression pattern of Prox1 in lymphatic vessels and other known Prox1-expressing organs. Importantly, tdTomato co-localized with the lymphatic markers Prox1, LYVE-1 and podoplanin as assessed by whole-mount immunofluorescence and FACS analysis. The tdTomato reporter was brighter than a previously established red fluorescent reporter line. We confirmed the applicability of this animal model to intravital microscopy of dendritic cell migration into and within lymphatic vessels, and to fluorescence-activated single cell analysis of lymphatic endothelial cells. Additionally, we were able to describe the early morphological changes of the lymphatic vasculature upon induction of skin inflammation. The Prox1-Cre-tdTomato reporter mouse thus shows great potential for lymphatic research.
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| 21. |
- Brändström, B. U. E., et al.
(författare)
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Results from the intercalibration of optical low-light calibration sources 2011
- 2012
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Ingår i: Geoscientific Instrumentation, Methods and Data Systems. - : European Geosciences Union (EGU). - 2193-0856 .- 2193-0864. ; 1, s. 43-51
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Tidskriftsartikel (refereegranskat)abstract
- Following the 38th Annual European Meeting on Atmospheric Studies by Optical Methods in Siuntio in Finland, an intercalibration workshop for optical low light calibration sources was held in Sodankylä, Finland. The main purpose of this workshop was to provide a comparable scale for absolute measurements of aurora and airglow. All sources brought to the intercalibration workshop were compared to the Fritz Peak reference source using the Lindau Calibration Photometer built by Wilhelm Barke and Hans Lauche in 1984. The results were compared to several earlier intercalibration workshops. It was found that most sources were fairly stable over time, with errors in the range of 5–25%. To further validate the results, two sources were also intercalibrated at UNIS, Longyearbyen, Svalbard. Preliminary analysis indicates agreement with the intercalibration in Sodankylä within about 15–25%.
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| 22. |
- Dixelius, Johan, et al.
(författare)
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Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
- 2003
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 278, s. 40973-
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Tidskriftsartikel (refereegranskat)abstract
- Vascular endothelial growth factors (VEGFs) regulate the development and growth of the blood and lymphatic vascular systems. Of the three VEGF receptors (VEGFR), VEGFR-1 and -2 are expressed on blood vessels; VEGFR-2 is found also on lymphatic vessels. VEGFR-3 is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Although VEGFR-3 is essential for proper lymphatic development, its signal transduction mechanisms are still incompletely understood. Trans-phosphorylation of activated, dimerized receptor tyrosine kinases is known to be critical for the regulation of kinase activity and for receptor interaction with signal transduction molecules. In this study, we have identified five tyrosyl phosphorylation sites in the VEGFR-3 carboxyl-terminal tail. These sites were used both in VEGFR-3 overexpressed in 293 cells and when the endogenous VEGFR-3 was activated in lymphatic endothelial cells. Interestingly, VEGF-C stimulation of lymphatic endothelial cells also induced the formation of VEGFR-3/VEGFR-2 heterodimers, in which VEGFR-3 was phosphorylated only at three of the five sites while the two most carboxyl-terminal tyrosine residues appeared not to be accessible for the VEGFR-2 kinase. Our data suggest that the carboxyl-terminal tail of VEGFR-3 provides important regulatory tyrosine phosphorylation sites with potential signal transduction capacity and that these sites are differentially used in ligand-induced homo- and heterodimeric receptor complexes.
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| 23. |
- Frye, Maike, et al.
(författare)
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Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
- 2018
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known. Here we show that matrix stiffness controls lymphatic vascular morphogenesis. Atomic force microscopy measurements in mouse embryos reveal that venous lymphatic endothelial cell (LEC) progenitors experience a decrease in substrate stiffness upon migration out of the cardinal vein, which induces a GATA2-dependent transcriptional program required to form the first lymphatic vessels. Transcriptome analysis shows that LECs grown on a soft matrix exhibit increased GATA2 expression and a GATA2-dependent upregulation of genes involved in cell migration and lymphangiogenesis, including VEGFR3. Analyses of mouse models demonstrate a cell-autonomous function of GATA2 in regulating LEC responsiveness to VEGF-C and in controlling LEC migration and sprouting in vivo. Our study thus uncovers a mechanism by which ECM stiffness dictates the migratory behavior of LECs during early lymphatic development.
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| 24. |
- Georgitsi, Marianthi, et al.
(författare)
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Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia.
- 2007
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 92:8, s. 3321-5
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Germline mutations in the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome, but in up to 20-25% of clinical MEN1 cases, no MEN1 mutations can be found. Recently, a germline mutation in the CDKN1B gene, encoding p27(Kip1), was reported in one suspected MEN1 family with two acromegalic patients.OBJECTIVE: Our objective was to evaluate the role of CDKN1B/p27(Kip1) in human tumor predisposition in patients clinically suspected of MEN1 but testing negative for MEN1 germline mutation as well as in familial and sporadic acromegaly/pituitary adenoma patients.DESIGN: Genomic DNA was analyzed for germline mutations in the CDKN1B/p27(Kip1) gene by PCR amplification and direct sequencing.SETTING: The study was conducted at nonprofit academic research and medical centers.PATIENTS: Thirty-six Dutch and one German suspected MEN1 patient, who previously tested negative for germline MEN1 gene mutations, were analyzed. In addition, 19 familial and 50 sporadic acromegaly/pituitary adenoma patients from Europe and the United States were included in the study.MAIN OUTCOME MEASURES: We analyzed germline CDKN1B/p27(Kip1) mutations in individuals with pituitary adenoma and MEN1-like features.RESULTS: A heterozygous 19-bp duplication (c.59_77dup19) leading to a truncated protein product was identified in one Dutch patient with suspected MEN1 phenotype, pituitary adenoma, carcinoid tumor, and hyperparathyroidism (one of 36, 2.8%). No mutations were detected in either familial or sporadic acromegaly/pituitary adenoma patients.CONCLUSIONS: Our results support the previous finding that germline CDKN1B/p27(Kip1) mutations predispose to a human MEN1-like condition. However, such mutations appear uncommon in suspected MEN1 cases and rare or nonexistent in familial or sporadic acromegaly/pituitary adenoma patients.
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| 25. |
- Haiko, Paula, et al.
(författare)
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Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.
- 2008
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Ingår i: Molecular and Cellular Biology. - 0270-7306 .- 1098-5549. ; 28:15
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Tidskriftsartikel (refereegranskat)abstract
- Lymphatic vessels play an important role in the regulation of tissue fluid balance, immune responses, and fat adsorption and are involved in diseases including lymphedema and tumor metastasis. Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) is necessary for development of the blood vasculature during early embryogenesis, but later, VEGFR-3 expression becomes restricted to the lymphatic vasculature. We analyzed mice deficient in both of the known VEGFR-3 ligands, VEGF-C and VEGF-D. Unlike the Vegfr3(-/-) embryos, the Vegfc(-/-); Vegfd(-/-) embryos displayed normal blood vasculature after embryonic day 9.5. Deletion of Vegfr3 in the epiblast, using keratin 19 (K19) Cre, resulted in a phenotype identical to that of the Vegfr3(-/-) embryos, suggesting that this phenotype is due to defects in the embryo proper and not in placental development. Interestingly, the Vegfr3(neo) hypomorphic mutant mice carrying the neomycin cassette between exons 1 and 2 showed defective lymphatic development. Overexpression of human or mouse VEGF-D in the skin, under the K14 promoter, rescued the lymphatic hypoplasia of the Vegfc(+/-) mice in the K14-VEGF-D; Vegfc(+/-) compound mice, suggesting that VEGF-D is functionally redundant with VEGF-C in the stimulation of developmental lymphangiogenesis. Our results suggest VEGF-C- and VEGF-D-independent functions for VEGFR-3 in the early embryo.
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| 26. |
- He, Yulong, et al.
(författare)
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Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.
- 2004
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 64:11
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Tidskriftsartikel (refereegranskat)abstract
- Endothelial progenitor cells have been shown to contribute to angiogenesis in various tumor models. Here, we have studied the relative contributions of bone marrow (BM)-derived endothelial progenitors and pre-existing lymphatic vessels to tumor lymphangiogenesis. We did not find significant incorporation of genetically marked BM-derived cells in lymphatic vessels during tumor- or vascular endothelial growth factor C-induced lymphangiogenesis. The degree of tumor lymphangiogenesis correlated with lymphatic vessel density in the peritumoral area, and despite tumor lymphangiogenesis, lymphatic metastasis failed to occur in gene-targeted vascular endothelial growth factor C(+/-) mice that have hypoplasia of the lymphatic network. Our data demonstrate that during tumor lymphangiogenesis and cancer cell dissemination via the lymphatics, the newly formed lymphatic vessels sprout from the pre-existing local lymphatic network with little if any incorporation of BM-derived endothelial progenitor cells.
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| 27. |
- Karkkainen, Marika J, et al.
(författare)
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Lymphatic endothelium : a new frontier of metastasis research.
- 2002
-
Ingår i: Nature Cell Biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- The vascular endothelium is a dynamic tissue with many active functions. Until recently, endothelial cell (EC) biology studies have used cultured ECs from various organs; these cell lines are considered representative of the blood vascular endothelium. Very few lymphatic EC lines have been available, and these were derived from lymphatic tumours or large collecting lymphatic ducts. In the past, lymphatic vessels were defined largely by the lack of erythrocytes in their lumen, a lack of junctional complexes and the lack of a well-defined basement membrane. Now that lymphatic-specific vascular endothelial growth factors (VEGF-C and VEGF-D) and molecular cell surface markers such as the VEGFR-3 receptor have been identified, this definition needs to be updated. Recent developments have highlighted the importance of lymphatic ECs, and they could become the next focus for angiogenesis and metastasis research.
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| 28. |
- Karpanen, Terhi, et al.
(författare)
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Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
- 2006
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Ingår i: American Journal of Pathology. - : Elsevier BV. - 0002-9440 .- 1525-2191. ; 169:2
-
Tidskriftsartikel (refereegranskat)abstract
- Lymphatic vessel plasticity and stability are of considerable importance when attempting to treat diseases associated with the lymphatic vasculature. Development of lymphatic vessels during embryogenesis is dependent on vascular endothelial growth factor (VEGF)-C but not VEGF-D. Using a recombinant adenovirus encoding a soluble form of their receptor VEGFR-3 (AdVEGFR-3-Ig), we studied lymphatic vessel dependency on VEGF-C and VEGF-D induced VEGFR-3 signaling in postnatal and adult mice. Transduction with AdVEGFR-3-Ig led to regression of lymphatic capillaries and medium-sized lymphatic vessels in mice under 2 weeks of age without affecting collecting lymphatic vessels or the blood vasculature. No effect was observed after this period. The lymphatic capillaries of neonatal mice also regressed partially in response to recombinant VEGFR-3-Ig or blocking antibodies against VEGFR-3, but not to adenovirus-encoded VEGFR-2-Ig. Despite sustained inhibitory VEGFR-3-Ig levels, lymphatic vessel regrowth was observed at 4 weeks of age. Interestingly, whereas transgenic expression of VEGF-C in the skin induced lymphatic hyperplasia even during embryogenesis, similar expression of VEGF-D resulted in lymphangiogenesis predominantly after birth. These results indicate considerable plasticity of lymphatic vessels during the early postnatal period but not thereafter, suggesting that anti-lymphangiogenic therapy can be safely applied in adults.
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| 29. |
- Kotilainen, Kirsi, et al.
(författare)
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Exploring the microfoundations of end-user interests toward co-creating renewable energy technology innovations
- 2019
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Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786. ; 229, s. 203-212
-
Tidskriftsartikel (refereegranskat)abstract
- Energy market transition, which is enabled by new affordable energy technologies and digitalization, opens novel opportunities for developing innovative energy solutions. These new technologies facilitate energy consumers to become local energy prosumers i.e. consumers and producers of energy using renewable energy sources. Hence, a central question for innovating new solutions emerges: how energy consumers and prosumers would engage in co-creating value and novel solutions with industry players? This article explores the microfoundations of energy consumers' and prosumers’ interest to participate in co-creation activities with energy industry actors. Using survey data from five European countries and by applying variance-based structural equation modeling, we find that rewards and personal characteristics influence the interest to engage in co-creation activities. Specifically, the microfoundations of the interest are built upon the need for improvements, the intrinsic rewards, and the personal adopter characteristics. Additionally, we find differing microfoundations of interest for energy consumers and prosumers. We further discuss managerial and theoretical implications of our findings and highlight avenues for future research.
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| 30. |
- Mellor, Russell H, et al.
(författare)
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Lymphatic dysfunction, not aplasia, underlies Milroy disease.
- 2010
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Ingår i: Microcirculation. - : Wiley. - 1073-9688 .- 1549-8719. ; 17:4
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Milroy disease is an inherited autosomal dominant lymphoedema caused by mutations in the gene for vascular endothelial growth factor receptor-3 (VEGFR-3, also known as FLT4). The phenotype has to date been ascribed to lymphatic aplasia. We further investigated the structural and functional defects underlying the phenotype in humans.METHODS: The skin of the swollen foot and the non-swollen forearm was examined by (i) fluorescence microlymphangiography, to quantify functional initial lymphatic density in vivo; and (ii) podoplanin and LYVE-1 immunohistochemistry of biopsies, to quantify structural lymphatic density. Leg vein function was assessed by colour Doppler duplex ultrasound.RESULTS: Milroy patients exhibited profound (86-91%) functional failure of the initial lymphatics in the foot; the forearm was unimpaired. Dermal lymphatics were present in biopsies but density was reduced by 51-61% (foot) and 26-33% (forearm). Saphenous venous reflux was present in 9/10 individuals with VEGFR3 mutations, including two carriers.CONCLUSION: We propose that VEGFR3 mutations in humans cause lymphoedema through a failure of tissue protein and fluid absorption. This is due to a profound functional failure of initial lymphatics and is not explained by microlymphatic hypoplasia alone. The superficial venous valve reflux indicates the dual role of VEGFR-3 in lymphatic and venous development.
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| 31. |
- Mellor, Russell H, et al.
(författare)
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Mutations in FOXC2 in humans (lymphoedema distichiasis syndrome) cause lymphatic dysfunction on dependency.
- 2011
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Ingår i: Journal of Vascular Research. - : S. Karger AG. - 1018-1172 .- 1423-0135. ; 48:5
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human lymphoedema distichiasis syndrome (LDS) results from germline mutations in transcription factor FOXC2. In a mouse model, lack of lymphatic and venous valves is observed plus abnormal smooth muscle cell recruitment to initial lymphatics. We investigated the mechanism of lymphoedema in humans with FOXC2 mutations, specifically the effect of gravitational forces on dermal lymphatic function.METHODS: We performed (1) quantitative fluorescence microlymphangiography (FML) on the skin of the forearm (non-swollen region) at heart level, and the foot (swollen region) below heart level (dependent) and then at heart level, and (2) immunohistochemical staining of microlymphatics in forearm and foot skin biopsies, using antibodies to podoplanin, LYVE-1 and smooth muscle actin.RESULTS: FML revealed a marked reduction in fluid uptake by initial lymphatics in the LDS foot during dependency, yet normal uptake (similar to controls) in the same foot at heart level and in LDS forearms. In control subjects, dependency did not impair initial lymphatic filling. Immunohistochemical microlymphatic density in forearm and foot did not differ between LDS and controls.CONCLUSIONS: FOXC2 mutations cause a functional failure of dermal initial lymphatics during gravitational stress (dependency), but not hypoplasia. The results reveal a pathophysiological mechanism contributing to swelling in LDS.
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| 32. |
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| 33. |
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| 34. |
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| 35. |
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| 36. |
- Mäkinen, Saku J., et al.
(författare)
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Prosumers’ digital business models for electric vehicles : Exploring microfoundations for a balanced policy approach
- 2019
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Ingår i: Digital business models. - Cham : Palgrave Macmillan. - 9783319969015 - 9783319969022 ; , s. 227-254
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Mäkinen et al. provide an indispensable view of business model opportunities for electric vehicle (EV) prosumers in the future energy market. The digitalization of energy markets has started a transformation to smart grids where information flows bi-directionally end to end between energy production and consumption. The chapter explores how prosumers can create, deliver, and capture value with EVs in future energy systems. Focusing on prosumers’ digital business models (DBMs), the chapter illustrates the complex interdependencies between various activities and actors needed in the development of an energy system. In addition to demonstrating prosumers’ EV DBMs and the current state of readiness in value creation, delivery, and capture, Mäkinen et al. develop a balanced policy approach that is based on these DBM microfoundations.
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| 37. |
- Mäkinen, Taija, et al.
(författare)
-
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
- 2001
-
Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 7:2
-
Tidskriftsartikel (refereegranskat)abstract
- The lymphatic vasculature transports extravasated tissue fluid, macromolecules and cells back into the blood circulation. Recent reports have focused on the molecular mechanisms regulating the lymphatic vessels. Vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to stimulate lymphangiogenesis and their receptor, VEGFR-3, has been linked to human hereditary lymphedema. Here we show that a soluble form of VEGFR-3 is a potent inhibitor of VEGF-C/VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal. Transgenic mice develop a lymphedema-like phenotype characterized by swelling of feet, edema and dermal fibrosis. They survive the neonatal period in spite of a virtually complete lack of lymphatic vessels in several tissues, and later show regeneration of the lymphatic vasculature, indicating that induction of lymphatic regeneration may also be possible in humans.
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| 38. |
- Olofsson, Anders D., 1973-, et al.
(författare)
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Digital competence across boundaries - beyond a common Nordic model of the digitalisation of K-12 schools?
- 2021
-
Ingår i: Education Inquiry. - : Taylor & Francis Group. - 2000-4508. ; 12:4, s. 317-328
-
Tidskriftsartikel (refereegranskat)abstract
- This paper explores policy related to digital competence and the digitalisation of Nordic K-12 schools. Anchored in some key transnational policies on digital competence, it describes some current Nordic movements in the national policies of Denmark, Finland, Norway and Sweden. The concept of boundary objects is used as an analytical lens, for understanding digital competence as a plastic and temporal concept that can be used to discuss the multi-dimensional translation of this concept in these Nordic countries. The paper ends with a discussion of the potential to view digital competence as a unifying boundary object that, with its plasticity, temporality and n-dimensionality, can show signs of common Nordic efforts in the K-12 school policy.
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| 39. |
- Ostergaard, Pia, et al.
(författare)
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Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).
- 2011
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:10
-
Tidskriftsartikel (refereegranskat)abstract
- We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia. GATA2 is a transcription factor that plays an essential role in gene regulation during vascular development and hematopoietic differentiation. Our findings indicate that haploinsufficiency of GATA2 underlies primary lymphedema and predisposes to acute myeloid leukemia in this syndrome.
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| 40. |
- Partanen, T A, et al.
(författare)
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Endothelial growth factor receptors in human fetal heart.
- 1999
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Ingår i: Circulation. - 0009-7322 .- 1524-4539. ; 100:6
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Endothelial receptor tyrosine kinases include 3 members of the vascular endothelial growth factor receptor (VEGFR) family and 2 members of the angiopoietin receptor (Tie) family. In addition, the VEGF(165) isoform binds to neuropilin-1 (NP-1), a receptor for collapsins/semaphorins. The importance of these receptors for vasculogenesis and angiogenesis has been shown in gene-targeted mice, but so far, little is known about their exact expression patterns in the human vasculature.METHODS AND RESULTS: Frozen sections of human fetal heart were stained immunohistochemically with receptor-specific monoclonal (VEGFR, Tie) or polyclonal (NP-1) antibodies. The following patterns were observed: The endocardium was positive for VEGFR-1, VEGFR-2, NP-1, Tie-1, and Tie-2 but negative for VEGFR-3. The coronary vessels were positive for Tie-1, Tie-2, VEGFR-1, and NP-1 and negative for VEGFR-2 and VEGFR-3. Myocardial capillaries and epicardial blood vessels stained for VEGFR-1, VEGFR-2, NP-1, and Tie-1; myocardial capillaries and epicardial veins weakly for Tie-2; and epicardial lymphatic vessels for VEGFR-2 and VEGFR-3, weakly for Tie-1 and Tie-2, but not for VEGFR-1 or NP-1.CONCLUSIONS: The results demonstrate differential expression of the endothelial growth factor receptors in distinct types of vessels in the human heart. This information is useful for the understanding of their roles in physiological and pathological processes and for their diagnostic and therapeutic application in cardiovascular medicine.
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| 41. |
- Saari, Ulla A., et al.
(författare)
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Assessing engineering students’ attitudes towards corporate social responsibility principles
- 2024
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Ingår i: European Journal of Engineering Education. - : Taylor & Francis. - 0304-3797 .- 1469-5898.
-
Tidskriftsartikel (refereegranskat)abstract
- Ethical and sustainable thinking is an important competence in the engineering education to support students’ abilities to act and perform in a responsible manner in corporate contexts, and consequently contribute to a sustainable future. This paper investigates engineering students’ attitudes towards ethical and sustainable thinking focusing on the corporate social responsibility (CSR) principles in the context of entrepreneurship courses as a part of larger research project. Engineering students from a Finnish and an Estonian university (N = 342) responded to a self-assessment survey. The students’ attitudes towards CSR principles were assessed both on the enterprise level and the individual level as expectations of potential future employees. The findings indicate that engineering students acknowledge the need to take into account responsible thinking and that it is important for enterprises to be both socially and environmentally responsible in their activities. The self-assessment tool of ethical and sustainable thinking associated with the entrepreneurship competence model and CSR principles can be helpful in practice when university teachers wish to support and assess their students’ attitudes towards CSR principles among other entrepreneurship competencies when creating new course content.
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| 42. |
- Saari, Ulla A., et al.
(författare)
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Engaging students in cross-disciplinary research and education—A processual approach to educational development
- 2019
-
Ingår i: Handbook of sustainability science and research. - Cham : Springer. - 9783319630069 - 9783319630076 ; , s. 353-363
-
Bokkapitel (refereegranskat)abstract
- The creation of future sustainable and efficient energy systems requires a cross-disciplinary approach in engineering education. In order for energy-related engineering students to be prepared for real-world situations after their studies, it is important that, while they are still studying, they obtain the basic skills for handling different concepts, theoretical frameworks and solution types created in the various disciplines involved. At the Tampere University of Technology (TUT), a cross-disciplinary team was formed from four different departments in three different faculties to create a platform for research and education purposes on the university campus. The purpose was to coordinate research and provide students with a wider picture and a concrete implementation of the different layers and aspects that need to be taken into account when creating innovative solutions for future digital energy systems. The creation of the platform started from a successful student ideation competition that produced many viable solutions. This paper describes the bottom-up incremental process by which the cross-disciplinary platform was created. The innovative solutions created in the student ideation competition convinced the university organization that the cross-disciplinary collaboration should have a more permanent platform on the university campus, allowing researchers and students to incorporate more sustainability and systemic aspects into their work, and having a positive impact on the sustainable energy consumption on the campus.
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| 43. |
- Saari, Ulla A., et al.
(författare)
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Exploring factors influencing the acceptance of social robots among early adopters and mass market representatives
- 2022
-
Ingår i: Robotics and Autonomous Systems. - : Elsevier. - 0921-8890 .- 1872-793X. ; 151
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Tidskriftsartikel (refereegranskat)abstract
- When designing social robots, it is crucial to understand the diverse expectations of different kinds of innovation adopters. Different factors influence early adopters of innovations and mass market representatives’ perceptions of the usefulness of social robots. The first aim of the study was to test how applicable the technology acceptance model 3 (TAM3) is in the context of social robots. Participants’ acceptance of social robotics in a workplace environment in the fuzzy front-end (FFE) innovation phase of a robot development project was examined. Based on the findings for the model, we developed a reduced version of the TAM3 that is more applicable for social robots. The second objective was to analyze how early adopters’ and mass market representatives’ acceptance of social robots differs. Quantitative research methods were used. For early adopters, result demonstrability has a significant influence on perceived usefulness of social robots, while for mass market representatives, perceived enjoyment has a more significant influence on perceived usefulness. The findings indicate that users’ innovation adoption style influences the factors that users consider important in the usefulness of social robots. Robot developers should take these into account during the FFE innovation phase.
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| 44. |
- Saari, Ulla A., et al.
(författare)
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From replication to further scale development : A case study of incorporating an eco-friendliness dimension in an existing consumer experience scale
- 2019
-
Ingår i: SAGE research methods cases. - London : Sage Publications.
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This case study describes how we developed a new dimension for measuring eco-friendliness in an existing brand experience measurement scale. We also replicated the original scale to test its generalizability in other countries. Extensions and replications of existing frameworks are important for validating current theories and testing their reliability, even though these research approaches are not yet commonly applied in marketing and business research. In this case study, we describe the research stages that we went through when replicating and extending the scale in two different countries: a small Western country and a large non-Western country. This case study also briefly presents the statistical methods we used (e.g., principal components analysis, confirmatory factor analysis, and structural equation modeling). Replications and extensions of existing frameworks with new dimensions for sustainability-related constructs could aid the field of business and management to further develop more theories on advancing sustainable business.
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| 45. |
- Saari, Ulla A., et al.
(författare)
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Measuring brand experiences cross-nationally
- 2017
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Ingår i: Journal of Brand Management. - : Springer. - 1350-231X .- 1479-1803. ; 24:1, s. 86-104
-
Tidskriftsartikel (refereegranskat)abstract
- The need for reliable and valid metrics for tracking consumers' experiences of products and brands cross-nationally is becoming ever more important as companies are increasingly operating in international markets. Brand experiences associated with global brands can manifest themselves very differently in different parts of the world; thus, the scales developed to track brand experiences should be validated cross-nationally. This research tests and revises an existing brand experience measurement scale cross-nationally in two countries that have very different cultural settings. Based on the findings from a survey with a sample of 1008 respondents, the authors propose a revised and shortened scale that provides more reliable and valid measurement results of brand experiences of global high-tech brands. In general, the results demonstrate the need for tests on the cross-national applicability of measurement scales and, even further, they underline the importance of replication research.
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| 46. |
- Saari, Ulla A., et al.
(författare)
-
Sustainable business model ideation and development of early ideas for sustainable business models : Analyzing a new tool facilitating the ideation process
- 2019
-
Ingår i: Sustainable business models. - Cham : Palgrave Macmillan. - 9783319932743 - 9783319932750 ; , s. 119-150
-
Bokkapitel (refereegranskat)abstract
- This chapter presents an early ideation tool, the Impact Canvas® (IC), that has been specifically designed to involve different kinds of stakeholders in the early stages of the business and research ideation process. The authors discuss how a tool can support the ideation process and how the IC tool has been designed to incorporate different elements for the development of sustainable and impactful ideas. The usefulness of the tool when cooperating in a multidisciplinary team is described. The authors report feedback from users of the tool that supports the perception of the user-friendliness and usefulness of the tool. The chapter concludes with a description of how the IC tool is being further developed to support a more multidisciplinary approach to research and business ideation.
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| 47. |
- Saari, Ulla A., et al.
(författare)
-
The vegan trend and the microfoundations of institutional change : A commentary on food producers’ sustainable innovation journeys in Europe
- 2021
-
Ingår i: Trends in Food Science & Technology. - : Elsevier. - 0924-2244 .- 1879-3053. ; 107, s. 161-167
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundToday's meat and dairy industry has a vast environmental footprint. To reach the UN sustainable development goals (SDGs) of ending hunger globally (SDG #2) and achieving sustainable consumption and production (SDG #12), this food production system needs to change. Recent years have seen the rise in popularity of the vegan or plant-based diet among consumers, which can go some way to reducing the environmental burden. This trend has motivated pioneering food producers to develop innovative vegan food products for niche markets, thus driving the sustainability transition of the food sector.Scope and approach This commentary tracks how three pioneering food companies have responded to the vegan trend in Europe. From the analysis of the sustainable innovation journeys of these innovative food producers, we propose a framework that presents a multi-level perspective on the socio-technical transition of the food production and consumption system.Key findings and conclusions The findings show how food producers, incumbents, and new entrants progress through an early phase of planning a direction and establishing a goal, followed by pivoting and experimenting in response to changes in the business environment. This innovation journey concludes as the company moves from experimentation and learning activities onto innovation implementation. The paper postulates a model that describes how regime level changes arise from the microfoundations of the food production and consumption system, as the innovation journeys of companies drive institutional change towards sustainability. The paper identifies future research avenues to explore the sustainable development of vegan food production in more depth.
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| 48. |
- Sabine, Amelie, et al.
(författare)
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FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature
- 2015
-
Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 125:10, s. 3861-3877
-
Tidskriftsartikel (refereegranskat)abstract
- Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell biology. In blood vessels, disturbed flow is associated with vascular diseases, such as atherosclerosis, and promotes endothelial cell proliferation and apoptosis. Here, we identified an important role for disturbed flow in lymphatic vessels, in which it cooperates with the transcription factor FOXC2 to ensure lifelong stability of the lymphatic vasculature. In cultured lymphatic endothelial cells, FOXC2 inactivation conferred abnormal shear stress sensing, promoting junction disassembly and entry into the cell cycle. Loss of FOXC2-dependent quiescence was mediated by the Hippo pathway transcriptional coactivator TAZ and, ultimately, led to cell death. In murine models, inducible deletion of Foxc2 within the lymphatic vasculature led to cell-cell junction defects, regression of valves, and focal vascular lumen collapse, which triggered generalized lymphatic vascular dysfunction and lethality. Together, our work describes a fundamental mechanism by which FOXC2 and oscillatory shear stress maintain lymphatic endothelial cell quiescence through intercellular junction and cytoskeleton stabilization and provides an essential link between biomechanical forces and endothelial cell identity that is necessary for postnatal vessel homeostasis. As FOXC2 is mutated in lymphedema-distichiasis syndrome, our data also underscore the role of impaired mechanotransduction in the pathology of this hereditary human disease.
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| 49. |
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| 50. |
- Timmen, Ludger, et al.
(författare)
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Observing Fennoscandian Gravity Change by Absolute Gravimetry
- 2006
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Ingår i: International Association of Geodesy Symposia, Vol. 131, Geodetic Deformation Monitoring: From Geophysical to Engineering Roles. ; , s. 193-199
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The Nordic countries Norway, Sweden, Denmark and Finland are a key study region for the research of glacial isostasy, and, in addition, it offers a unique opportunity for validating and testing the results of the GRACE experiment. Over a period of five years, the expected life time of GRACE, a temporal geoid variation of 3.0 mm is expected in the centre of the Fennoscandian land uplift area, corresponding to a gravity change of about 100 nm/s2. This is expected to be within the detection capabilities of GRACE. With terrestrial absolute gravimetry, the gravity change due to the land uplift can be observed with an accuracy of ±10 to 20 nm/s2 for a 5-year period. Thus, the terrestrial insitu observations (ground-truth) may be used to validate and test the GRACE results.Since 2003, absolute gravity measurements have been performed in Fennoscandia at about 30 stations covering Norway, Sweden, Finland and Denmark. Four groups with FG5 absolute gravimeters (BKG, FGI, IfE, UMB) are engaged to survey the uplift network annually by a mutually controlled procedure. Nearly all absolute stations are colocated with permanent GPS stations. From the 2003 and 2004 comparisons between the instruments, an overall accuracy of ±30 nm/s2 is indicated for a single absolute gravimeter and a single station determination. This is in full agreement with the project goal.
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