| 1. |
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| 2. |
- Ghetti, R., et al.
(författare)
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Influence of multiple sources on the two-neutron correlation function in Ni-induced, intermediate energy, heavy ion reactions
- 2001
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Ingår i: Physical Review C. Nuclear Physics. - : American Physical Society. - 0556-2813 .- 1089-490X. ; 64:1
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Tidskriftsartikel (refereegranskat)abstract
- The strength of the neutron-neutron correlation function from the E=45AMeV58Ni+27Al, natNi, and 197Au reactions depends on the neutron parallel velocity. This indicates the presence of multiple sources of neutron emission. We find these sources consistent with a dissipative, binary reaction mechanism as it is described by, e.g., Boltzmann-Uehling-Uhlenbeck calculations.
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| 3. |
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| 4. |
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| 5. |
- Urrata, M, et al.
(författare)
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Neutron-neutron Intensity Interferometry in E/A = 45 MeV 58Ni + 27Al, 58Ni and 197Au Reactions
- 2000
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Ingår i: Physical Review C. Nuclear Physics. - : American Institute of Physics (AIP). - 0556-2813 .- 1089-490X. ; 62
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Tidskriftsartikel (refereegranskat)abstract
- Small angle neutron-neutron correlations have been measured for the E/A=45 MeV 58Ni+27Al, natNi, and 197Au reactions. Two-neutron correlation functions, both integrated and gated on the total momentum of the neutron pair, have been constructed. In order to explain these data, a fraction of fast "dynamical" emission is needed in addition to slower evaporative emission. The overall emission time scale is shorter for the symmetric system, indicating that the dynamical component is stronger in this case.
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| 6. |
- G., Aad, et al.
(författare)
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A search for the Zγ decay mode of the Higgs boson in pp collisions at s=13 TeV with the ATLAS detector
- 2020
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 809
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Tidskriftsartikel (refereegranskat)abstract
- A search for the Zγ decay of the Higgs boson, with Z boson decays into pairs of electrons or muons is presented. The analysis uses proton–proton collision data at s = 13 TeV corresponding to an integrated luminosity of 139 fb−1 recorded by the ATLAS detector at the Large Hadron Collider. The observed data are consistent with the expected background with a p-value of 1.3%. An upper limit at 95% confidence level on the production cross-section times the branching ratio for pp→H→Zγ is set at 3.6 times the Standard Model prediction while 2.6 times is expected in the presence of the Standard Model Higgs boson. The best-fit value for the signal yield normalised to the Standard Model prediction is 2.0−0.9 +1.0 where the statistical component of the uncertainty is dominant. © 2020 The Author
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| 7. |
- G., Aad, et al.
(författare)
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CP Properties of Higgs Boson Interactions with Top Quarks in the t t ¯ H and tH Processes Using H →γγ with the ATLAS Detector
- 2020
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Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 125:6
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Tidskriftsartikel (refereegranskat)abstract
- A study of the charge conjugation and parity (CP) properties of the interaction between the Higgs boson and top quarks is presented. Higgs bosons are identified via the diphoton decay channel (H→γγ), and their production in association with a top quark pair (tt¯H) or single top quark (tH) is studied. The analysis uses 139 fb-1 of proton-proton collision data recorded at a center-of-mass energy of s=13 TeV with the ATLAS detector at the Large Hadron Collider. Assuming a CP-even coupling, the tt¯H process is observed with a significance of 5.2 standard deviations. The measured cross section times H→γγ branching ratio is 1.64-0.36+0.38(stat)-0.14+0.17(sys) fb, and the measured rate for tt¯H is 1.43-0.31+0.33(stat)-0.15+0.21(sys) times the Standard Model expectation. The tH production process is not observed and an upper limit on its rate of 12 times the Standard Model expectation is set. A CP-mixing angle greater (less) than 43 (-43)° is excluded at 95% confidence level. © 2020 CERN.
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| 8. |
- G., Aad, et al.
(författare)
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Evidence for electroweak production of two jets in association with a Zγ pair in pp collisions at s=13 TeV with the ATLAS detector
- 2020
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 803
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Tidskriftsartikel (refereegranskat)abstract
- Evidence for electroweak production of two jets in association with a Zγ pair in s=13 TeV proton–proton collisions at the Large Hadron Collider is presented. The analysis uses data collected by the ATLAS detector in 2015 and 2016 that corresponds to an integrated luminosity of 36.1fb−1. Events that contain a Z boson candidate decaying leptonically into either e+e− or μ+μ−, a photon, and two jets are selected. The electroweak component is measured with observed and expected significances of 4.1 standard deviations. The fiducial cross-section for electroweak production is measured to be σZγjj−EW=7.8±2.0fb, in good agreement with the Standard Model prediction. © 2020 The Author(s)
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| 9. |
- G., Aad, et al.
(författare)
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Measurement of soft-drop jet observables in pp collisions with the ATLAS detector at s =13 TeV
- 2020
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 101:5
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Tidskriftsartikel (refereegranskat)abstract
- Jet substructure quantities are measured using jets groomed with the soft-drop grooming procedure in dijet events from 32.9 fb-1 of pp collisions collected with the ATLAS detector at s=13 TeV. These observables are sensitive to a wide range of QCD phenomena. Some observables, such as the jet mass and opening angle between the two subjets which pass the soft-drop condition, can be described by a high-order (resummed) series in the strong coupling constant αS. Other observables, such as the momentum sharing between the two subjets, are nearly independent of αS. These observables can be constructed using all interacting particles or using only charged particles reconstructed in the inner tracking detectors. Track-based versions of these observables are not collinear safe, but are measured more precisely, and universal nonperturbative functions can absorb the collinear singularities. The unfolded data are directly compared with QCD calculations and hadron-level Monte Carlo simulations. The measurements are performed in different pseudorapidity regions, which are then used to extract quark and gluon jet shapes using the predicted quark and gluon fractions in each region. All of the parton shower and analytical calculations provide an excellent description of the data in most regions of phase space. © 2020 CERN.
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| 10. |
- G., Aad, et al.
(författare)
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Measurement of the cross-section and charge asymmetry of W bosons produced in proton–proton collisions at √s=8TeV with the ATLAS detector
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:9
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents measurements of the W+→ μ+ν and W-→ μ-ν cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton–proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2fb-1. The precision of the cross-section measurements varies between 0.8 and 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 11. |
- G., Aad, et al.
(författare)
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Performance of the ATLAS muon triggers in Run 2
- 2020
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Ingår i: Journal of Instrumentation. - : IOP Publishing. - 1748-0221. ; 15:9
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Tidskriftsartikel (refereegranskat)abstract
- The performance of the ATLAS muon trigger system is evaluated with proton-proton (pp) and heavy-ion (HI) collision data collected in Run 2 during 2015-2018 at the Large Hadron Collider. It is primarily evaluated using events containing a pair of muons from the decay of Z bosons to cover the intermediate momentum range between 26 GeV and 100 GeV. Overall, the efficiency of the single-muon triggers is about 68% in the barrel region and 85% in the endcap region. The pT range for efficiency determination is extended by using muons from decays of Jψ mesons, W bosons, and top quarks. The performance in HI collision data is measured and shows good agreement with the results obtained in pp collisions. The muon trigger shows uniform and stable performance in good agreement with the prediction of a detailed simulation. Dedicated multi-muon triggers with kinematic selections provide the backbone to beauty, quarkonia, and low-mass physics studies. The design, evolution and performance of these triggers are discussed in detail. © 2020 CERN for the benefit of the ATLAS collaboration..
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| 12. |
- G., Aad, et al.
(författare)
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Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in s =13 TeV pp collisions with the ATLAS detector
- 2020
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 101:7
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Tidskriftsartikel (refereegranskat)abstract
- A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of s=13 TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb-1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015-2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV. © 2020 CERN. © 2020 CERN, for the ATLAS Collaboration.
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| 13. |
- G., Aad, et al.
(författare)
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Search for heavy diboson resonances in semileptonic final states in pp collisions at √s=13 TeV with the ATLAS detector
- 2020
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 80:12
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports on a search for heavy resonances decaying into WW, ZZ or WZ using proton–proton collision data at a centre-of-mass energy of s=13 TeV. The data, corresponding to an integrated luminosity of 139 fb 1, were recorded with the ATLAS detector from 2015 to 2018 at the Large Hadron Collider. The search is performed for final states in which one W or Z boson decays leptonically, and the other W boson or Z boson decays hadronically. The data are found to be described well by expected backgrounds. Upper bounds on the production cross sections of heavy scalar, vector or tensor resonances are derived in the mass range 300–5000 GeV within the context of Standard Model extensions with warped extra dimensions or including a heavy vector triplet. Production through gluon–gluon fusion, Drell–Yan or vector-boson fusion are considered, depending on the assumed model. © 2020, CERN for the benefit of the ATLAS collaboration.
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| 14. |
- G., Aad, et al.
(författare)
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Search for Heavy Higgs Bosons Decaying into Two Tau Leptons with the ATLAS Detector Using pp Collisions at s =13 TeV
- 2020
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 125:5
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Tidskriftsartikel (refereegranskat)abstract
- A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb-1 of proton-proton collisions at s=13 TeV recorded with the ATLAS detector. The search for heavy resonances is performed over the mass range 0.2-2.5 TeV for the τ+τ-decay with at least one τ-lepton decaying into final states with hadrons. The data are in good agreement with the background prediction of the standard model. In the Mh125 scenario of the minimal supersymmetric standard model, values of tanβ>8 and tanβ>21 are excluded at the 95% confidence level for neutral Higgs boson masses of 1.0 and 1.5 TeV, respectively, where tanβ is the ratio of the vacuum expectation values of the two Higgs doublets. © 2020 CERN.
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| 15. |
- G., Aad, et al.
(författare)
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Search for long-lived, massive particles in events with a displaced vertex and a muon with large impact parameter in pp collisions at s =13 TeV with the ATLAS detector
- 2020
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Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 1550-7998 .- 1550-2368. ; 102:3
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Tidskriftsartikel (refereegranskat)abstract
- A search for long-lived particles decaying into hadrons and at least one muon is presented. The analysis selects events that pass a muon or missing-transverse-momentum trigger and contain a displaced muon track and a displaced vertex. The analyzed dataset of proton-proton collisions at s=13 TeV was collected with the ATLAS detector and corresponds to 136 fb-1. The search employs dedicated reconstruction techniques that significantly increase the sensitivity to long-lived particle decays that occur in the ATLAS inner detector. Background estimates for Standard Model processes and instrumental effects are extracted from data. The observed event yields are compatible with those expected from background processes. The results are presented as limits at 95% confidence level on model-independent cross sections for processes beyond the Standard Model, and interpreted as exclusion limits in scenarios with pair production of long-lived top squarks that decay via a small R-parity-violating coupling into a quark and a muon. Top squarks with masses up to 1.7 TeV are excluded for a lifetime of 0.1 ns, and masses below 1.3 TeV are excluded for lifetimes between 0.01 ns and 30 ns. © 2020 CERN.
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| 16. |
- G., Aad, et al.
(författare)
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Search for long-lived neutral particles produced in pp collisions at s =13 TeV decaying into displaced hadronic jets in the ATLAS inner detector and muon spectrometer
- 2020
-
Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 101:5
-
Tidskriftsartikel (refereegranskat)abstract
- A search is presented for pair production of long-lived neutral particles using 33 fb-1 of s=13 TeV proton-proton collision data, collected during 2016 by the ATLAS detector at the LHC. This search focuses on a topology in which one long-lived particle decays in the ATLAS inner detector and the other decays in the muon spectrometer. Special techniques are employed to reconstruct the displaced tracks and vertices in the inner detector and in the muon spectrometer. One event is observed that passes the full event selection, which is consistent with the estimated background. Limits are placed on scalar boson propagators with masses from 125 GeV to 1000 GeV decaying into pairs of long-lived hidden-sector scalars with masses from 8 GeV to 400 GeV. The limits placed on several low-mass scalars extend previous exclusion limits in the range of proper lifetimes cτ from 5 cm to 1 m. © 2020 CERN.
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| 17. |
- G., Aad, et al.
(författare)
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Searches for electroweak production of supersymmetric particles with compressed mass spectra in s =13 TeV pp collisions with the ATLAS detector
- 2020
-
Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 101:5
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents results of searches for the electroweak production of supersymmetric particles in models with compressed mass spectra. The searches use 139 fb-1 of s=13 TeV proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider. Events with missing transverse momentum and two same-flavor, oppositely charged, low-transverse-momentum leptons are selected, and are further categorized by the presence of hadronic activity from initial-state radiation or a topology compatible with vector-boson fusion processes. The data are found to be consistent with predictions from the Standard Model. The results are interpreted using simplified models of R-parity-conserving supersymmetry in which the lightest supersymmetric partner is a neutralino with a mass similar to the lightest chargino, the second-to-lightest neutralino, or the slepton. Lower limits on the masses of charginos in different simplified models range from 193 to 240 GeV for moderate mass splittings, and extend down to mass splittings of 1.5 to 2.4 GeV at the LEP chargino bounds (92.4 GeV). Similar lower limits on degenerate light-flavor sleptons extend up to masses of 251 GeV and down to mass splittings of 550 MeV. Constraints on vector-boson fusion production of electroweak SUSY states are also presented. © 2020 CERN.
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| 18. |
- Mansoor, Rashid, et al.
(författare)
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Haematological consequences of acute uncomplicated falciparum malaria : a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data
- 2022
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Ingår i: BMC Medicine. - : Springer Nature. - 1741-7015. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundPlasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia.MethodsIndividual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multivariable logistic regression quantified risk factors for moderately severe anaemia (haemoglobin < 7 g/dL) at day 0, day 3 and day 7 as well as a fractional fall >= 25% at day 3 and day 7.ResultsA total of 70,226 patients, recruited into 200 studies between 1991 and 2013, were included in the analysis: 50,859 (72.4%) enrolled in Africa, 18,451 (26.3%) in Asia and 916 (1.3%) in South America. The median haemoglobin concentration at presentation was 9.9 g/dL (range 5.0-19.7 g/dL) in Africa, 11.6 g/dL (range 5.0-20.0 g/dL) in Asia and 12.3 g/dL (range 6.9-17.9 g/dL) in South America. Moderately severe anaemia (Hb < 7g/dl) was present in 8.4% (4284/50,859) of patients from Africa, 3.3% (606/18,451) from Asia and 0.1% (1/916) from South America. The nadir haemoglobin occurred on day 2 post treatment with a mean fall from baseline of 0.57 g/dL in Africa and 1.13 g/dL in Asia. Independent risk factors for moderately severe anaemia on day 7, in both Africa and Asia, included moderately severe anaemia at baseline (adjusted odds ratio (AOR) = 16.10 and AOR = 23.00, respectively), young age (age < 1 compared to >= 12 years AOR = 12.81 and AOR = 6.79, respectively), high parasitaemia (AOR = 1.78 and AOR = 1.58, respectively) and delayed parasite clearance (AOR = 2.44 and AOR = 2.59, respectively). In Asia, patients treated with an artemisinin-based regimen were at significantly greater risk of moderately severe anaemia on day 7 compared to those treated with a non-artemisinin-based regimen (AOR = 2.06 [95%CI 1.39-3.05], p < 0.001).ConclusionsIn patients with uncomplicated P. falciparum malaria, the nadir haemoglobin occurs 2 days after starting treatment. Although artemisinin-based treatments increase the rate of parasite clearance, in Asia they are associated with a greater risk of anaemia during recovery.
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| 19. |
- Blanco, A., et al.
(författare)
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Performance of timing resistive plate chambers with relativistic neutrons from 300 to 1500 MeV
- 2015
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Ingår i: Journal of Instrumentation. - : IOP Publishing. - 1748-0221. ; 10:2
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Tidskriftsartikel (refereegranskat)abstract
- A prototype composed of four resistive plate chamber layers has been exposed to quasi-monoenergetic neutrons produced from a deuteron beam of varying energy (300 to 1500 AMeV) in experiment S406 at GSI, Darmstad, Germany. Each layer, with an active area of about 2000 × 500 mm2, is made of modules containing the active gaps, all in multigap construction. Each gap is defined by 0.3 mm nylon mono-filaments positioned between 2.85 mm thick float glass electrodes. The modules are operated in avalanche mode with a non-flammable gas mixture composed of 90% C2H2F4 and 10% SF6. The signals are readout by a pick-up electrode formed by 15 copper strips (per layer), spaced at a pitch of 30 mm, connected at both sides to timing front end electronics. Measurements of the time of flight jitter of neutrons, in the mentioned energy range, point to a contribution of the resistive plate chamber in the order of 150 ps, independent of the neutron energy.
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| 20. |
- Bruxvoort, K. J., et al.
(författare)
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The Impact of Introducing Malaria Rapid Diagnostic Tests on Fever Case Management: A Synthesis of Ten Studies from the ACT Consortium
- 2017
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Ingår i: Am J Trop Med Hyg. - : American Society of Tropical Medicine and Hygiene. - 0002-9637 .- 1476-1645. ; 97:4, s. 1170-1179
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Tidskriftsartikel (refereegranskat)abstract
- Since 2010, the World Health Organization has been recommending that all suspected cases of malaria be confirmed with parasite-based diagnosis before treatment. These guidelines represent a paradigm shift away from presumptive antimalarial treatment of fever. Malaria rapid diagnostic tests (mRDTs) are central to implementing this policy, intended to target artemisinin-based combination therapies (ACT) to patients with confirmed malaria and to improve management of patients with nonmalarial fevers. The ACT Consortium conducted ten linked studies, eight in sub-Saharan Africa and two in Afghanistan, to evaluate the impact of mRDT introduction on case management across settings that vary in malaria endemicity and healthcare provider type. This synthesis includes 562,368 outpatient encounters (study size range 2,400-432,513). mRDTs were associated with significantly lower ACT prescription (range 8-69% versus 20-100%). Prescribing did not always adhere to malaria test results; in several settings, ACTs were prescribed to more than 30% of test-negative patients or to fewer than 80% of test-positive patients. Either an antimalarial or an antibiotic was prescribed for more than 75% of patients across most settings; lower antimalarial prescription for malaria test-negative patients was partly offset by higher antibiotic prescription. Symptomatic management with antipyretics alone was prescribed for fewer than 25% of patients across all scenarios. In community health worker and private retailer settings, mRDTs increased referral of patients to other providers. This synthesis provides an overview of shifts in case management that may be expected with mRDT introduction and highlights areas of focus to improve design and implementation of future case management programs.
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| 21. |
- Dahal, Prabin, et al.
(författare)
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Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria : a WorldWide Antimalarial Resistance Network individual participant data meta-analysis
- 2019
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Ingår i: Malaria Journal. - : BMC. - 1475-2875. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- Background: Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent recrudescence of persistent, sub-microscopic primary infections.Methods: Antimalarial studies typically report the risk of recrudescence derived using the Kaplan-Meier (K-M) method, which considers new infections acquired during the follow-up period as censored. Cumulative Incidence Function (CIF) provides an alternative approach for handling new infections, which accounts for them as a competing risk event. The complement of the estimate derived using the K-M method (1 minus K-M), and the CIF were used to derive the risk of recrudescence at the end of the follow-up period using data from studies collated in the WorldWide Antimalarial Resistance Network data repository. Absolute differences in the failure estimates derived using these two methods were quantified. In comparative studies, the equality of two K-M curves was assessed using the log-rank test, and the equality of CIFs using Gray's k-sample test (both at 5% level of significance). Two different regression modelling strategies for recrudescence were considered: cause-specific Cox model and Fine and Gray's sub-distributional hazard model.Results: Data were available from 92 studies (233 treatment arms, 31,379 patients) conducted between 1996 and 2014. At the end of follow-up, the median absolute overestimation in the estimated risk of cumulative recrudescence by using 1 minus K-M approach was 0.04% (interquartile range (IQR): 0.00-0.27%, Range: 0.00-3.60%). The overestimation was correlated positively with the proportion of patients with recrudescence [Pearson's correlation coefficient (rho): 0.38, 95% Confidence Interval (CI) 0.30-0.46] or new infection [rho: 0.43; 95% CI 0.35-0.54]. In three study arms, the point estimates of failure were greater than 10% (the WHO threshold for withdrawing antimalarials) when the K-M method was used, but remained below 10% when using the CIF approach, but the 95% confidence interval included this threshold.Conclusions: The 1 minus K-M method resulted in a marginal overestimation of recrudescence that became increasingly pronounced as antimalarial efficacy declined, particularly when the observed proportion of new infection was high. The CIF approach provides an alternative approach for derivation of failure estimates in antimalarial trials, particularly in high transmission settings.
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| 22. |
- Dahal, Prabin, et al.
(författare)
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Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy : an individual participant data meta-analysis
- 2022
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Ingår i: Malaria Journal. - : Springer Nature. - 1475-2875. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Background: The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria.Methods: Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide Antimalarial Resistance Network (WWARN) repository with at least 28 days follow-up were available. The temporal and cumulative distributions of recrudescence were characterized using a Cox regression model with shared frailty on study-sites. Fractional polynomials were used to capture non-linear instantaneous hazard. The area under the density curve (AUC) of the constructed distribution was used to estimate the optimal follow-up period for capturing a P. falciparum malaria recrudescence. Simulation studies were conducted based on the constructed distributions to quantify the absolute overestimation in efficacy due to sub-optimal follow-up.Results: Overall, 3703 recurrent infections were detected in 60 studies conducted in Africa (15,512 children aged < 5 years) and 23 studies conducted in Asia and South America (5272 patients of all ages). Using molecular genotyping, 519 (14.0%) recurrences were ascribed as recrudescent infections. A 28 day artemether-lumefantrine (AL) efficacy trial would not have detected 58% [95% confidence interval (CI) 47-74%] of recrudescences in African children and 32% [95% CI 15-45%] in patients of all ages in Asia/South America. The corresponding estimate following a 42 day dihydroartemisinin-piperaquine (DP) efficacy trial in Africa was 47% [95% CI 19-90%] in children under 5 years old treated with > 48 mg/kg total piperaquine (PIP) dose and 9% [95% CI 0-22%] in those treated with <= 48 mg/kg PIP dose. In absolute terms, the simulation study found that trials limited to 28 days follow-up following AL underestimated the risk of recrudescence by a median of 2.8 percentage points compared to day 63 estimates and those limited to 42 days following DP underestimated the risk of recrudescence by a median of 2.0 percentage points compared to day 42 estimates. The analysis was limited by few clinical trials following patients for longer than 42 days (9 out of 83 trials) and the imprecision of PCR genotyping which overcalls recrudescence in areas of higher transmission biasing the later distribution.Conclusions: Restricting follow-up of clinical efficacy trials to day 28 for AL and day 42 for DP will miss a proportion of late recrudescent treatment failures but will have a modest impact in derived efficacy. The results highlight that as genotyping methods improve consideration should be given for trials with longer duration of follow-up to detect early indications of emerging drug resistance.
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| 23. |
- del Rio, J. S., et al.
(författare)
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CEPA: A LaBr 3 (Ce)/LaCl 3 (Ce) phoswich array for simultaneous detection of protons and gamma radiation emitted in reactions at relativistic energies
- 2014
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Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 66
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Konferensbidrag (refereegranskat)abstract
- A prototype CEPA4, made of four optically isolated phoswich-crystals of LaBr3(Ce)+LaCl3(Ce) packed together in one can of Al, was tested with high energy protons (70-230 MeV) at the cyclotron of Krakow. Further, the response to different gamma radiation standard sources and cosmic muons was determined. Shape analysis of the pulses derived from the four individually coupled PM-tubes was performed and were used as input functions for Monte Carlo simulations in order to simulate the efficiencies and resolutions of a final detector design consisting of 750 such phoswich crystals arranged in a cylindrical disc. © Owned by the authors, published by EDP Sciences, 2014.
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| 24. |
- del Rio, J. S., et al.
(författare)
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CEPA: A LaBr3(Ce)/LaCl3(Ce) Phoswich array for simultaneous detection of protons and gamma radiation emitted in reactions at relativistic energies
- 2014
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Ingår i: International Journal of Modern Physics: Conference Series. Applications of Nuclear Techniques (CRETE13). - 2010-1945. ; 27, s. 1460143-
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Konferensbidrag (refereegranskat)abstract
- A sophisticated design of 750 LaBr3(Ce):LaCl3(Ce) phoswich crystals (CEPA10) with a segmentation determined by the Doppler correction and an energy resolution of 5% at 1 MeV is presented. Monte Carlo simulations have been performed for high energy protons (50–500 MeV) and gamma radiation (0.5–30 MeV) to determine the length and shape of the crystals for optimum performance of the detector. In the case of protons, the two-layer detector can be used as a ΔELaBr3 − ETot telescope or, for very high energies, as a double energy loss detector (ΔELaBr3 + ΔELaCl3), in order to determine the initial energy. In addition, an experimental test with high energy protons (70–230 MeV) was performed at the cyclotron center in Krakow, Poland with a first prototype of 2 x 2 phoswich rectangular crystals (CEPA4) packed in an aluminum can (0.5 mm case). To simulate CEPA10 efficiencies and resolutions, optical pulses detected in CEPA4 by photomultiplier tubes with a DAQ system were used as energy input functions in Monte Carlo simulations.
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| 25. |
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| 26. |
- Engdahl, Cecilia, 1983, et al.
(författare)
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Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: A potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women
- 2018
-
Ingår i: Arthritis Research and Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 20:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vanish with menopause. Fc sialylation is a crucial factor determining the inflammatory effector function of antibodies. We therefore analyzed whether E2 affects immunoglobulin G (IgG) sialylation. Methods: Postmenopausal (ovariectomized) mice were immunized with ovalbumin and treated with E2 or vehicle. Total and ovalbumin-specific IgG concentrations, sialylation, and Fcγ receptor expression were analyzed. Postmenopausal women with RA receiving hormone replacement therapy, including E2, or no treatment were analyzed for IgG sialylation. Furthermore, effects of E2 on the expression of the sialylation enzyme β-galactoside α2,6-sialyltransferase 1 (St6Gal1) were studied in mouse and human antibody-producing cells. Results: E2 treatment significantly increased Fc sialylation of total and ovalbumin-specific IgG in postmenopausal mice. Furthermore, E2 led to increased expression of inhibitory Fcγ receptor IIb on bone marrow leukocytes. Treatment with E2 also increased St6Gal1 expression in mouse and human antibody-producing cells, providing a mechanistic explanation for the increase in IgG-Fc sialylation. In postmenopausal women with RA, treatment with E2 significantly increased the Fc sialylation of IgG. Conclusions: E2 induces anti-inflammatory effector functions in IgG by inducing St6Gal1 expression in antibody-producing cells and by increasing Fc sialylation. These observations provide a mechanistic explanation for the increased risk of RA in conditions with low estrogen levels such as menopause. © 2018 The Author(s).
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| 27. |
- Hopkins, H., et al.
(författare)
-
Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings
- 2017
-
Ingår i: Bmj-British Medical Journal. - : BMJ. - 1756-1833 .- 0959-8138. ; 356
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES To examine the impact of use of rapid diagnostic tests for malaria on prescribing of antimicrobials, specifically antibiotics, for acute febrile illness in Africa and Asia. Analysis of nine preselected linked and codesigned observational and randomised studies (eight cluster or individually randomised trials and one observational study). Public and private healthcare settings, 2007-13, in Afghanistan, Cameroon, Ghana, Nigeria, Tanzania, and Uganda. Proportions of patients for whom an antibiotic was prescribed in trial groups who had undergone rapid diagnostic testing compared with controls and in patients with negative test results compared with patients with positive results. A secondary aim compared classes of antibiotics prescribed in different settings. Antibiotics were prescribed to 127 052/238 797 (53%) patients in control groups and 167 714/283 683 (59%) patients in intervention groups. Antibiotics were prescribed to 40% (35 505/89 719) of patients with a positive test result for malaria and to 69% (39 400/57 080) of those with a negative result. All but one study showed a trend toward more antibiotic prescribing in groups who underwent rapid diagnostic tests. Random effects meta-analysis of the trials showed that the overall risk of antibiotic prescription was 21% higher (95% confidence interval 7% to 36%) in intervention settings. In most intervention settings, patients with negative test results received more antibiotic prescriptions than patients with positive results for all the most commonly used classes: penicillins, trimethoprim-sulfamethoxazole (one exception), tetracyclines, and metronidazole. Introduction of rapid diagnostic tests for malaria to reduce unnecessary use of antimalarials-a beneficial public health outcome-could drive up untargeted use of antibiotics. That 69% of patients were prescribed antibiotics when test results were negative probably represents overprescription. This included antibiotics from several classes, including those like metronidazole that are seldom appropriate for febrile illness, across varied clinical, health system, and epidemiological settings. It is often assumed that better disease specific diagnostics will reduce antimicrobial overuse, but they might simply shift it from one antimicrobial class to another. Current global implementation of malaria testing might increase untargeted antibiotic use and must be examined.
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| 28. |
- Kundrat, J., et al.
(författare)
-
GNPy : Lessons Learned and Future Plans [Invited]
- 2022
-
Ingår i: 2022 European Conference on Optical Communication, ECOC 2022. - : Institute of Electrical and Electronics Engineers Inc.. - 9781957171159
-
Konferensbidrag (refereegranskat)abstract
- We discuss the history, past challenges and future plans of GNPy, an open source project for simulating physical impairments in contemporary DWDM network. The paper describes the unique interaction among network operators, equipment vendors, and standard bodies, as well as challenges in implementing the digital twin of an optical network.
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| 29. |
- Kundrat, J., et al.
(författare)
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GNPy YANG : Open APIs for End-to-End Service Provisioning in Optical Networks
- 2021
-
Ingår i: 2021 Optical Fiber Communications Conference and Exhibition, OFC 2021 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781943580866
-
Konferensbidrag (refereegranskat)abstract
- We demonstrate end-to-end service provisioning in a fully disaggregated optical network using open software interfaces. The GNPy quality-of-transmission estimator is extended with a YANG-based API. The YANG modeling work builds on the IETF standard schemas, and describes multiple layers of the network at once.
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| 30. |
- Machado, J., et al.
(författare)
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Performance of timing Resistive Plate Chambers with protons from 200 to 800 MeV
- 2015
-
Ingår i: Journal of Instrumentation. - 1748-0221. ; 10:1, s. C01043-
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Tidskriftsartikel (refereegranskat)abstract
- A prototype composed of four resistive plate chamber layers has been exposed to quasi-monoenergetic protons produced from a deuteron beam of varying energy (200 to 800 AMeV) in experiment S406 at GSI, Darmstadt, Germany. The aim of the experiment is to characterize the response of the prototype to protons in this energy range, which deposit from 1.75 to 6 times more energy than minimum ionizing particles. Each layer, with an active area of about 2000 × 500 mm 2 , is made of modules containing the active gaps, all in multigap construction. Each gap is defined by 0.3 mm nylon mono-filaments positioned between 2.85 mm thick float glass electrodes. The modules are operated in avalanche mode with a non-flammable gas mixture composed of 90% C 2 H 2 F 4 and 10% SF 6 . The signals are readout by a pick-up electrode formed by 15 copper strips (per layer), spaced at a pitch of 30 mm, connected at both sides to timing front end electronics. Results show an uniform efficiency close to 100% along with a timing resolution of around 60 ps on the entire 2000 × 500 mm 2 area.
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| 31. |
- Mullier, G.A., et al.
(författare)
-
A search for the dimuon decay of the Standard Model Higgs boson with the ATLAS detector
- 2021
-
Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 812
-
Tidskriftsartikel (refereegranskat)abstract
- A search for the dimuon decay of the Standard Model (SM) Higgs boson is performed using data corresponding to an integrated luminosity of 139 fb−1 collected with the ATLAS detector in Run 2 pp collisions at s=13 TeV at the Large Hadron Collider. The observed (expected) significance over the background-only hypothesis for a Higgs boson with a mass of 125.09 GeV is 2.0σ (1.7σ). The observed upper limit on the cross section times branching ratio for pp→H→μμ is 2.2 times the SM prediction at 95% confidence level, while the expected limit on a H→μμ signal assuming the absence (presence) of a SM signal is 1.1 (2.0). The best-fit value of the signal strength parameter, defined as the ratio of the observed signal yield to the one expected in the SM, is μ=1.2±0.6. © 2020 The Author(s)
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| 32. |
- Mullier, G.A., et al.
(författare)
-
Measurement of cross sections for production of a Z boson in association with a flavor-inclusive or doubly b-tagged large-radius jet in proton-proton collisions at Formula Presented with the ATLAS experiment
- 2023
-
Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 108:1
-
Tidskriftsartikel (refereegranskat)abstract
- We present measurements of cross sections for production of a leptonically decaying Z boson in association with a large-radius jet in 13 TeV proton-proton collisions at the LHC, using 36 fb - 1 of data from the ATLAS detector. Integrated and differential cross sections are measured at particle level in both a flavor inclusive and a doubly b -tagged fiducial phase space. The large-radius jet mass and transverse momentum, its kinematic relationship to the Z boson, and the angular separation of b -tagged small-radius track jets within the large-radius jet are measured. This measurement constitutes an important test of perturbative quantum chromodynamics in kinematic and flavor configurations relevant to several Higgs boson and beyond-Standard-Model physics analyses. The results highlight issues with modeling of additional hadronic activity in the flavor-inclusive selection, and a distinction between flavor-number schemes in the b -tagged phase space. © 2023 CERN, for the ATLAS Collaboration.
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| 33. |
- Mullier, G.A., et al.
(författare)
-
Measurement of the associated production of a Higgs boson decaying into b-quarks with a vector boson at high transverse momentum in pp collisions at s=13 TeV with the ATLAS detector
- 2021
-
Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 816
-
Tidskriftsartikel (refereegranskat)abstract
- The associated production of a Higgs boson with a W or Z boson decaying into leptons and where the Higgs boson decays to a bb¯ pair is measured in the high vector-boson transverse momentum regime, above 250 GeV, with the ATLAS detector. The analysed data, corresponding to an integrated luminosity of 139 fb−1, were collected in proton–proton collisions at the Large Hadron Collider between 2015 and 2018 at a centre-of-mass energy of s=13 TeV. The measured signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model, is 0.72−0.36 +0.39 corresponding to an observed (expected) significance of 2.1 (2.7) standard deviations. Cross-sections of associated production of a Higgs boson decaying into b quark pairs with a W or Z gauge boson, decaying into leptons, are measured in two exclusive vector boson transverse momentum regions, 250–400 GeV and above 400 GeV, and interpreted as constraints on anomalous couplings in the framework of a Standard Model effective field theory. © 2021 The Author
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| 34. |
- Mullier, G.A., et al.
(författare)
-
Measurement of the top-quark mass using a leptonic invariant mass in pp collisions at √s = 13 TeV with the ATLAS detector
- 2023
-
Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media Deutschland GmbH. - 1029-8479 .- 1126-6708. ; 2023:6
-
Tidskriftsartikel (refereegranskat)abstract
- A measurement of the top-quark mass (mt) in the tt¯ → lepton + jets channel is presented, with an experimental technique which exploits semileptonic decays of b-hadrons produced in the top-quark decay chain. The distribution of the invariant mass mℓμ of the lepton, ℓ (with ℓ = e, μ), from the W-boson decay and the muon, μ, originating from the b-hadron decay is reconstructed, and a binned-template profile likelihood fit is performed to extract mt. The measurement is based on data corresponding to an integrated luminosity of 36.1 fb−1 of s = 13 TeV pp collisions provided by the Large Hadron Collider and recorded by the ATLAS detector. The measured value of the top-quark mass is mt = 174.41 ± 0.39 (stat.) ± 0.66 (syst.) ± 0.25 (recoil) GeV, where the third uncertainty arises from changing the Pythia8 parton shower gluon-recoil scheme, used in top-quark decays, to a recently developed setup. [Figure not available: see fulltext.]. © 2023, The Author(s).
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| 35. |
- Mullier, G.A., et al.
(författare)
-
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √s=13TeV
- 2021
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 81:6
-
Tidskriftsartikel (refereegranskat)abstract
- The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb - 1 of s=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95-0.36+0.38 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon. © 2021, CERN for the benefit of the ATLAS collaboration.
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| 36. |
- Mullier, G.A., et al.
(författare)
-
Muon reconstruction and identification efficiency in ATLAS using the full Run 2 pp collision data set at √s=13 TeV
- 2021
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 81:7
-
Tidskriftsartikel (refereegranskat)abstract
- This article documents the muon reconstruction and identification efficiency obtained by the ATLAS experiment for 139 fb - 1 of pp collision data at s=13 TeV collected between 2015 and 2018 during Run 2 of the LHC. The increased instantaneous luminosity delivered by the LHC over this period required a reoptimisation of the criteria for the identification of prompt muons. Improved and newly developed algorithms were deployed to preserve high muon identification efficiency with a low misidentification rate and good momentum resolution. The availability of large samples of Z→ μμ and J/ ψ→ μμ decays, and the minimisation of systematic uncertainties, allows the efficiencies of criteria for muon identification, primary vertex association, and isolation to be measured with an accuracy at the per-mille level in the bulk of the phase space, and up to the percent level in complex kinematic configurations. Excellent performance is achieved over a range of transverse momenta from 3 GeV to several hundred GeV, and across the full muon detector acceptance of | η| < 2.7. © 2021, CERN for the benefit of the ATLAS collaboration.
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| 37. |
- Mullier, G.A., et al.
(författare)
-
Observation of photon-induced W+W− production in pp collisions at s=13 TeV using the ATLAS detector
- 2021
-
Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 816
-
Tidskriftsartikel (refereegranskat)abstract
- This letter reports the observation of photon-induced production of W-boson pairs, γγ→WW. The analysis uses 139 fb−1 of LHC proton–proton collision data taken at s=13 TeV recorded by the ATLAS experiment during the years 2015–2018. The measurement is performed selecting one electron and one muon, corresponding to the decay of the diboson system as WW→e±νμ∓ν final state. The background-only hypothesis is rejected with a significance of well above 5 standard deviations consistent with the expectation from Monte Carlo simulation. A cross section for the γγ→WW process of 3.13±0.31(stat.)±0.28(syst.) fb is measured in a fiducial volume close to the acceptance of the detector, by requiring an electron and a muon of opposite signs with large dilepton transverse momentum and exactly zero additional charged particles. This is found to be in agreement with the Standard Model prediction. © 2021 The Author(s)
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| 38. |
- Mullier, G.A., et al.
(författare)
-
Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector
- 2021
-
Ingår i: Nature Physics. - : Springer Science and Business Media LLC. - 1745-2473 .- 1745-2481. ; 17:7, s. 819-825
-
Tidskriftsartikel (refereegranskat)abstract
- Leptons with essentially the same properties apart from their mass are grouped into three families (or flavours). The number of leptons of each flavour is conserved in interactions, but this is not imposed by fundamental principles. Since the formulation of the standard model of particle physics, the observation of flavour oscillations among neutrinos has shown that lepton flavour is not conserved in neutrino weak interactions. So far, there has been no experimental evidence that this also occurs in interactions between charged leptons. Such an observation would be a sign of undiscovered particles or a yet unknown type of interaction. Here the ATLAS experiment at the Large Hadron Collider at CERN reports a constraint on lepton-flavour-violating effects in weak interactions, searching for Z-boson decays into a τ lepton and another lepton of different flavour with opposite electric charge. The branching fractions for these decays are measured to be less than 8.1 × 10−6 (eτ) and 9.5 × 10−6 (μτ) at the 95% confidence level using 139 fb−1 of proton–proton collision data at a centre-of-mass energy of s=13TeV and 20.3 fb−1 at s=8TeV. These results supersede the limits from the Large Electron–Positron Collider experiments conducted more than two decades ago. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
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| 39. |
- Mullier, G.A., et al.
(författare)
-
Search for quantum black hole production in lepton + jet final states using proton-proton collisions at vs = 13 TeV with the ATLAS detector
- 2024
-
Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 109:3
-
Tidskriftsartikel (refereegranskat)abstract
- A search for quantum black holes in electron + jet and muon + jet invariant mass spectra is performed with 140 fb-1 of data collected by the ATLAS detector in proton-proton collisions at √s = 13 TeV at the Large Hadron Collider. The observed invariant mass spectrum of lepton + jet pairs is consistent with Standard Model expectations. Upper limits are set at 95% confidence level on the production cross section times branching fractions for quantum black holes decaying into a lepton and a quark in a search region with invariant mass above 2.0 TeV. The resulting quantum black hole lower mass threshold limit is 9.2 TeV in the Arkani-Hamed-Dimopoulos-Dvali model, and 6.8 TeV in the Randall-Sundrum model. © 2024 CERN, for the ATLAS Collaboration.
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| 40. |
- Mullier, G.A., et al.
(författare)
-
Search for squarks and gluinos in final states with jets and missing transverse momentum using 139 fb−1 of √s = 13 TeV pp collision data with the ATLAS detector
- 2021
-
Ingår i: Journal of High Energy Physics. - : Springer Nature. - 1029-8479 .- 1126-6708. ; 2021:2
-
Tidskriftsartikel (refereegranskat)abstract
- A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing jets and missing transverse momentum, but no electrons or muons, is presented. The data used in this search were recorded by the ATLAS experiment in proton-proton collisions at a centre-of-mass energy of s = 13 TeV during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb−1. The results are interpreted in the context of various R-parity-conserving models where squarks and gluinos are produced in pairs or in association and a neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 2.30 TeV for a simplified model containing only a gluino and the lightest neutralino, assuming the latter is massless. For a simplified model involving the strong production of mass-degenerate first- and second-generation squarks, squark masses below 1.85 TeV are excluded if the lightest neutralino is massless. These limits extend substantially beyond the region of supersymmetric parameter space excluded previously by similar searches with the ATLAS detector. [Figure not available: see fulltext.] © 2021, The Author(s).
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| 41. |
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| 42. |
- Aaboud, M, et al.
(författare)
-
Measurement of lepton differential distributions and the top quark mass in tt¯ production in pp collisions at √s=8 TeV with the ATLAS detector
- 2017
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:11
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents single lepton and dilepton kinematic distributions measured in dileptonic tt¯ events produced in 20.2fb - 1 of s=8 TeV pp collisions recorded by the ATLAS experiment at the LHC. Both absolute and normalised differential cross-sections are measured, using events with an opposite-charge eμ pair and one or two b-tagged jets. The cross-sections are measured in a fiducial region corresponding to the detector acceptance for leptons, and are compared to the predictions from a variety of Monte Carlo event generators, as well as fixed-order QCD calculations, exploring the sensitivity of the cross-sections to the gluon parton distribution function. Some of the distributions are also sensitive to the top quark pole mass; a combined fit of NLO fixed-order predictions to all the measured distributions yields a top quark mass value of mtpole=173.2±0.9±0.8±1.2 GeV, where the three uncertainties arise from data statistics, experimental systematics, and theoretical sources. © 2017, CERN for the benefit of the ATLAS collaboration.
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| 43. |
- Aaboud, M, et al.
(författare)
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Measurements of top-quark pair differential cross-sections in the lepton+jets channel in pp collisions at √s=13 TeV using the ATLAS detector
- 2017
-
Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 2017:11
-
Tidskriftsartikel (refereegranskat)abstract
- Measurements of differential cross-sections of top-quark pair production in fiducial phase-spaces are presented as a function of top-quark and tt¯ system kinematic observables in proton-proton collisions at a centre-of-mass energy of s=13 TeV. The data set corresponds to an integrated luminosity of 3.2 fb−1, recorded in 2015 with the ATLAS detector at the CERN Large Hadron Collider. Events with exactly one electron or muon and at least two jets in the final state are used for the measurement. Two separate selections are applied that each focus on different top-quark momentum regions, referred to as resolved and boosted topologies of the tt¯ final state. The measured spectra are corrected for detector effects and are compared to several Monte Carlo simulations by means of calculated χ2 and p-values. © 2017, The Author(s).
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| 44. |
- Aaboud, M, et al.
(författare)
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Search for a Structure in the Bs0 π± Invariant Mass Spectrum with the ATLAS Experiment
- 2018
-
Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 1079-7114 .- 0031-9007. ; 120:20
-
Tidskriftsartikel (refereegranskat)abstract
- A search for the narrow structure, X(5568), reported by the D0 Collaboration in the decay sequence X→Bs0π±, Bs0→J/ψφ, is presented. The analysis is based on a data sample recorded with the ATLAS detector at the LHC corresponding to 4.9 fb-1 of pp collisions at 7 TeV and 19.5 fb-1 at 8 TeV. No significant signal was found. Upper limits on the number of signal events, with properties corresponding to those reported by D0, and on the X production rate relative to Bs0 mesons, ρX, were determined at 95% confidence level. The results are N(X)
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| 45. |
- Aaboud, M, et al.
(författare)
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Search for Dark Matter Produced in Association with a Higgs Boson Decaying to b b Using 36 fb-1 of pp Collisions at s =13 TeV with the ATLAS Detector
- 2017
-
Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 119:18
-
Tidskriftsartikel (refereegranskat)abstract
- Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb pair with the ATLAS detector using 36.1 fb-1 of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The observed data are in agreement with the standard model predictions and limits are placed on the associated production of dark-matter particles and a Higgs boson. © 2017 CERN, for the ATLAS Collaboration. Published by the American Physical Society.
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| 46. |
- Aaboud, M, et al.
(författare)
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Search for exclusive Higgs and Z boson decays to ϕγ and ργ with the ATLAS detector
- 2018
-
Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 2018:7
-
Tidskriftsartikel (refereegranskat)abstract
- A search for the exclusive decays of the Higgs and Z bosons to a ϕ or ρ meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of up to 35.6 fb−1 collected at s=13 TeV with the ATLAS detector at the CERN Large Hadron Collider. These decays have been suggested as a probe of the Higgs boson couplings to light quarks. No significant excess of events is observed above the background, as expected from the Standard Model. Upper limits at 95% confidence level were obtained on the branching fractions of the Higgs boson decays to ϕγ and ργ of 4.8 × 10−4 and 8.8 × 10−4, respectively. The corresponding 95% confidence level upper limits for the Z boson decays are 0.9 × 10−6 and 25 × 10−6 for ϕγ and ργ, respectively.[Figure not available: see fulltext.]. © 2018, The Author(s).
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| 47. |
- Aad, G, et al.
(författare)
-
Alignment of the ATLAS Inner Detector in Run 2
- 2020
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 80:12
-
Tidskriftsartikel (refereegranskat)abstract
- The performance of the ATLAS Inner Detector alignment has been studied using pp collision data at s=13TeV collected by the ATLAS experiment during Run 2 (2015–2018) of the Large Hadron Collider (LHC). The goal of the detector alignment is to determine the detector geometry as accurately as possible and correct for time-dependent movements. The Inner Detector alignment is based on the minimization of track-hit residuals in a sequence of hierarchical levels, from global mechanical assembly structures to local sensors. Subsequent levels have increasing numbers of degrees of freedom; in total there are almost 750,000. The alignment determines detector geometry on both short and long timescales, where short timescales describe movements within an LHC fill. The performance and possible track parameter biases originating from systematic detector deformations are evaluated. Momentum biases are studied using resonances decaying to muons or to electrons. The residual sagitta bias and momentum scale bias after alignment are reduced to less than ∼0.1TeV-1 and 0.9 × 10 - 3, respectively. Impact parameter biases are also evaluated using tracks within jets. © 2020, The Author(s).
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| 48. |
- Aad, G., et al.
(författare)
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Combination of searches for invisible decays of the Higgs boson using 139 fb−1 of proton-proton collision data at √s=13 TeV collected with the ATLAS experiment
- 2023
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 842
-
Tidskriftsartikel (refereegranskat)abstract
- Many extensions of the Standard Model predict the production of dark matter particles at the LHC. Sufficiently light dark matter particles may be produced in decays of the Higgs boson that would appear invisible to the detector. This Letter presents a statistical combination of searches for H→invisible decays where multiple production modes of the Standard Model Higgs boson are considered. These searches are performed with the ATLAS detector using 139 fb−1 of proton–proton collisions at a centre–of–mass energy of at the LHC. In combination with the results at √s=7TeV and 8TeV, an upper limit on the H→invisible branching ratio of 0.107 (0.077) at the 95% confidence level is observed (expected). These results are also interpreted in the context of models where the 125 GeV Higgs boson acts as a portal to dark matter, and limits are set on the scattering cross-section of weakly interacting massive particles and nucleons.
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| 49. |
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| 50. |
- Aad, G., et al.
(författare)
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Determination of the strong coupling constant from transverse energy-energy correlations in multijet events at √ s=13 TeV with the ATLAS detector
- 2023
-
Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479. ; 2023:7
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of transverse energy-energy correlations and their associated azimuthal asymmetries in multijet events are presented. The analysis is performed using a data sample corresponding to 139 fb-1 of proton-proton collisions at a centre-of-mass energy of root s = 13TeV, collected with the ATLAS detector at the Large Hadron Collider. The measurements are presented in bins of the scalar sum of the transverse momenta of the two leading jets and unfolded to particle level. They are then compared to next-to-next-to-leading-order perturbative QCD calculations for the first time, which feature a significant reduction in the theoretical uncertainties estimated using variations of the renormalisation and factorisation scales. The agreement between data and theory is good, thus providing a precision test of QCD at large momentum transfers Q. The strong coupling constant alpha(s) is extracted as a function of Q, showing a good agreement with the renormalisation group equation and with previous analyses. A simultaneous fit to all transverse energy-energy correlation distributions across different kinematic regions yields a value of alpha(s)( mZ) = 0.1175 +/- 0.0006 (exp.)(+0.0034) (-0.0017) (theo.), while the global fit to the asymmetry distributions yields alpha(s)(m(Z)) = 0.1185 +/- 0.0009 (exp.)(+0.0025)(-0.0012)(theo.).
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