| 1. |
- Deans, Andrew R, et al.
(författare)
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Finding Our Way through Phenotypes.
- 2015
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Ingår i: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.
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| 2. |
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| 3. |
- Lundberg, Hans, et al.
(författare)
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High-gain Soft-x-ray Pumped Photoionization Laser in Zinc Vapor
- 1984
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 45:4
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Tidskriftsartikel (refereegranskat)abstract
- Large inversion densities in Zn+ have been produced by photoionizing inner #x2010;shell d electrons with the broadband soft #x2010;x #x2010;ray flux from a 1.06 #x2010; #x3bc;m laser #x2010;produced plasma. This pumping scheme is an effective technique for rapidly producing large population densities (5 #xd7;1013 cm-3) in the 3d9 #x2009;4s2 #x2009;2D5/2 upper laser level. These large densities (a) produced laser action on a two #x2010;electron transition from the d #x2010;electron manifold to the outer #x2010;electron manifold at 7478 #xc5;, (b) allowed the isotope shifts on this relatively weak transition to be measured, and (c) may eventually be transferred to other high lying states in Zn+ to produce vacuum ultraviolet lasers.
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| 4. |
- Sanders, Luciana M., et al.
(författare)
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Carbon accumulation in Amazonian floodplain lakes : A significant component of Amazon budgets?
- 2017
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Ingår i: Limnology and Oceanography Letters. - : Wiley. - 2378-2242. ; 2:1, s. 29-35
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Tidskriftsartikel (refereegranskat)abstract
- The Amazon floodplains cover approximately 10% of the Amazon Basin and are composed of predominantly anoxic sediments that may store large amounts of carbon. Our study combines Pb-210 derived sedimentation rates from four recently analyzed sediment cores (n = 4) with previously published organic carbon (OC) burial estimates (n = 18) to provide a broad, first order estimate of carbon accumulation in Amazon floodplain lakes. The OC burial rates were 266 +/- 57 g C m(-2) yr(-1). This rate is several folds greater than those reported for lakes in arctic, boreal, temperate, and tropical regions. The large amount and spatial variation of OC burial rates in these floodplain lakes highlights the need for increased sampling efforts to better measure these potentially important components of the Amazon Basin carbon budget.
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| 5. |
- Silfvast, W. T., et al.
(författare)
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Stimulated emission in the ultraviolet by optical pumping from photoionization-produced inner-shell states in Cd$+$
- 1985
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Ingår i: Optics Letters. - 0146-9592. ; 10:3, s. 122-124
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Tidskriftsartikel (refereegranskat)abstract
- Stimulated emission on three UV transitions in Cd$+$ has been observed by transferring population from inner-shell d-electron states, populated by photoionization, to outer-shell p-electron states using the output from a narrow-frequency dye laser. The use of similar techniques in other elements could eventually result in a number of new lasers in the UV and VUV.
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| 6. |
- Wilkinson, M. E., et al.
(författare)
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A cloud based tool for knowledge exchange on local scale flood risk
- 2015
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Ingår i: Journal of Environmental Management. - : Elsevier BV. - 0301-4797 .- 1095-8630. ; 161, s. 38-50
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Tidskriftsartikel (refereegranskat)abstract
- There is an emerging and urgent need for new approaches for the management of environmental challenges such as flood hazard in the broad context of sustainability. This requires a new way of working which bridges disciplines and organisations, and that breaks down science-culture boundaries. With this, there is growing recognition that the appropriate involvement of local communities in catchment management decisions can result in multiple benefits. However, new tools are required to connect organisations and communities. The growth of cloud based technologies offers a novel way to facilitate this process of exchange of information in environmental science and management; however, stakeholders need to be engaged with as part of the development process from the beginning rather than being presented with a final product at the end. Here we present the development of a pilot Local Environmental Virtual Observatory Flooding Tool. The aim was to develop a cloud based learning platform for stakeholders, bringing together fragmented data, models and visualisation tools that will enable these stakeholders to make scientifically informed environmental management decisions at the local scale. It has been developed by engaging with different stakeholder groups in three catchment case studies in the UK and a panel of national experts in relevant topic areas. However, these case study catchments are typical of many northern latitude catchments. The tool was designed to communicate flood risk in locally impacted communities whilst engaging with landowners/farmers about the risk of runoff from the farmed landscape. It has been developed iteratively to reflect the needs, interests and capabilities of a wide range of stakeholders. The pilot tool combines cloud based services, local catchment datasets, a hydrological model and bespoke visualisation tools to explore real time hydrometric data and the impact of flood risk caused by future land use changes. The novel aspects of the pilot tool are; the co-evolution of tools on a cloud based platform with stakeholders, policy and scientists; encouraging different science disciplines to work together; a wealth of information that is accessible and understandable to a range of stakeholders; and provides a framework for how to approach the development of such a cloud based tool in the future. Above all, stakeholders saw the tool and the potential of cloud technologies as an effective means to taking a whole systems approach to solving environmental issues. This sense of community ownership is essential in order to facilitate future appropriate and acceptable land use management decisions to be co-developed by local catchment communities. The development processes and the resulting pilot tool could be applied to local catchments globally to facilitate bottom up catchment management approaches.
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| 7. |
- van den Berg, Leonard H., et al.
(författare)
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Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials
- 2019
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Ingår i: Neurology. - : Wolters Kluwer. - 0028-3878 .- 1526-632X. ; 92:14, s. E1610-E1623
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS).Methods: A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patient representatives, research funding representatives, industry, and regulatory agencies) addressed 9 areas of need within ALS research: (1) preclinical studies; (2) biological and phenotypic heterogeneity; (3) outcome measures; (4) disease-modifying and symptomatic interventions; (5) recruitment and retention; (6) biomarkers; (7) clinical trial phases; (8) beyond traditional trial designs; and (9) statistical considerations. Assigned to 1 of 8 sections, committee members generated a draft set of guidelines based on a “background” of developing a (pre)clinical question and a “rationale” outlining the evidence and expert opinion. Following a 2-day, face-to-face workshop at the Airlie House Conference Center, a modified Delphi process was used to develop draft consensus research guidelines, which were subsequently reviewed and modified based on comments from the public. Statistical experts drafted a separate document of statistical considerations (section 9).Results: In this report, we summarize 112 guidelines and their associated backgrounds and rationales. The full list of guidelines, the statistical considerations, and a glossary of terms can be found in data available from Dryad (appendices e-3–e-5, doi.org/10.5061/dryad.32q9q5d). The authors prioritized 15 guidelines with the greatest potential to improve ALS clinical research.Conclusion: The revised Airlie House ALS Clinical Trials Consensus Guidelines should serve to improve clinical trial design and accelerate the development of effective treatments for patients with ALS.
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