| 1. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
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| 3. |
- Borges, A. H., et al.
(författare)
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Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials
- 2016
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1058-4838 .- 1537-6591. ; 63:2, s. 268-280
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Tidskriftsartikel (refereegranskat)abstract
- Background. Previous studies suggest that nonnucleoside reverse-transcriptase inhibitors (NNRTIs) cause faster virologic suppression, while ritonavir-boosted protease inhibitors (PI/r) recover more CD4 cells. However, individual trials have not been powered to compare clinical outcomes. Methods. We searched databases to identify randomized trials that compared NNRTI-vs PI/r-based initial therapy. A meta-analysis calculated risk ratios (RRs) or mean differences (MDs), as appropriate. Primary outcome was death or progression to AIDS. Secondary outcomes were death, progression to AIDS, and treatment discontinuation. We calculated RR of virologic suppression and MD for an increase in CD4 cells at week 48. Results. We included 29 trials with 9047 participants. Death or progression to AIDS occurred in 226 participants in the NNRTI arm and in 221 in the PI/r arm (RR, 1.03; 95% confidence interval, .87-1.22; 12 trials; n = 3825), death in 205 participants in the NNRTI arm vs 198 in the PI/r arm (1.04; 0.86-1.25; 22 trials; n = 8311), and progression to AIDS in 140 participants in the NNRTI arm vs 144 in the PI/r arm (1.00; 0.80-1.25; 13 trials; n = 4740). Overall treatment discontinuation (1.12; 0.93-1.35; 24 trials; n = 8249) and from toxicity (1.21; 0.87-1.68; 21 trials; n = 6195) were comparable, but discontinuation due to virologic failure was more common with NNRTI (1.58; 0.91-2.74; 17 trials; n = 5371). At week 48, there was no difference between NNRTI and PI/r in virologic suppression (RR, 1.03; 0.98-1.09) or CD4(+) recovery (MD, -4.7 cells; -14.2 to 4.8). Conclusions. We found no difference in clinical and viro-immunologic outcomes between NNRTI-and PI/r-based therapy.
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| 4. |
- Gunell, H., et al.
(författare)
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Plasma penetration of the dayside magnetopause
- 2012
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Ingår i: Physics of Plasmas. - Melville, NY : AIP Publishing. - 1070-664X .- 1089-7674. ; 19:7, s. 072906-
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Tidskriftsartikel (refereegranskat)abstract
- Data from the Cluster spacecraft during their magnetopause crossing on 25 January 2002 are presented. The magnetopause was in a state of slow non-oscillatory motion during the observational period. Coherent structures of magnetosheath plasma, here typified as plasmoids, were seen on closed magnetic field lines on the inside of the magnetopause. Using simultaneous measurements on two spacecraft, the inward motion of the plasmoids is followed from one spacecraft to the next, and it is found to be in agreement with the measured ion velocity. The plasma characteristics and the direction of motion of the plasmoids show that they have penetrated the magnetopause, and the observations are consistent with the concept of impulsive penetration, as it is known from theory, simulations, and laboratory experiments. The mean flux across the magnetopause observed was 0.2%-0.5% of the solar wind flux at the time, and the peak values of the flux inside the plasmoids reached approximately 20% of the solar wind flux.
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| 5. |
- Mailyan, B., et al.
(författare)
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Transpolar arc observation after solar wind entry into the high-latitude magnetosphere
- 2015
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 120:5, s. 3525-3534
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Tidskriftsartikel (refereegranskat)abstract
- Recently, Cluster observations have revealed the presence of new regions of solar wind plasma entry at the high-latitude magnetospheric lobes tailward of the cusp region, mostly during periods of northward interplanetary magnetic field. In this study, observations from the Global Ultraviolet Imager (GUVI) experiment on board the TIMED spacecraft and Wideband Imaging Camera imager on board the IMAGE satellite are used to investigate a possible link between solar wind entry and the formation of transpolar arcs in the polar cap. We focus on a case when transpolar arc formation was observed twice right after the two solar wind entry events were detected by the Cluster spacecraft. In addition, GUVI and IMAGE observations show a simultaneous occurrence of auroral activity at low and high latitudes after the second entry event, possibly indicating a two-part structure of the continuous band of the transpolar arc.
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| 6. |
- Echim, M. M., et al.
(författare)
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A Method to Estimate the Physical Properties of Magnetospheric Generators From Observations of Quiet Discrete Auroral Arcs
- 2019
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 124:12, s. 10283-10293
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Tidskriftsartikel (refereegranskat)abstract
- We discuss a method to estimate the properties of a magnetospheric generator using a quasi-electrostatic magnetosphere-ionosphere coupling model and in situ or remote sensing observations of discrete quiet arcs. We first construct an ensemble of Vlasov equilibrium solutions for generator structures formed at magnetospheric plasma interfaces. For each generator solution, we compute the ionospheric electric potential from the current continuity equation. Thus, we estimate the field-aligned potential drop that allows us to assess several properties of the discrete auroral arc, such as the field-aligned potential difference, the field-aligned current density, the flux of precipitating energy, and the height-integrated Pedersen conductance. A minimization procedure based on comparing the numerical results with observations is defined and applied to find which solution of the current continuity equation and which generator model give auroral arc properties that best fit the observations. The procedure is validated in a case study with observations by DMSP and Cluster and can be generalized to other types of data.
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| 7. |
- Gunell, H, et al.
(författare)
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Acceleration of ions and nano dust at a comet in the solar wind
- 2015
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Ingår i: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 119, s. 13-23
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Tidskriftsartikel (refereegranskat)abstract
- A quasi-neutral hybrid simulation of the interaction of the solar wind with the atmosphere of a comet is used together with a test particle simulation of cometary ions and dust to compute trajectories and velocity distribution functions of charged particles, starting outside the diamagnetic cavity at 150 km cometocentric distance. The simulations are run with parameters suited to make predictions for comet 67P/Churyumov-Gerasimenko when it is at a heliocentric distance of 1.45 AU. It is found that the shape of the ion trajectories depends on the location of the source, and that a velocity distribution that is observed at a given point in space is influenced by the spatial structure of the source. Charged dust grains with radii in the 1-10 nm range are accelerated from the nucleus to a distance of 2.9 x 104 km in between 15 min and 2 h approximately. Dust particles smaller than 10 nm in radius are accelerated to speeds over 10 km/s.
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| 8. |
- Gunell, H., et al.
(författare)
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Ion acoustic waves at comet 67P/Churyumov-Gerasimenko : Observations and computations
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 600
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Tidskriftsartikel (refereegranskat)abstract
- Context. On 20 January 2015 the Rosetta spacecraft was at a heliocentric distance of 2.5 AU, accompanying comet 67P/Churyumov-Gerasimenko on its journey toward the Sun. The Ion Composition Analyser (RPC-ICA), other instruments of the Rosetta Plasma Consortium, and the ROSINA instrument made observations relevant to the generation of plasma waves in the cometary environment.Aims. Observations of plasma waves by the Rosetta Plasma Consortium Langmuir probe (RPC-LAP) can be explained by dispersion relations calculated based on measurements of ions by the Rosetta Plasma Consortium Ion Composition Analyser (RPC-ICA), and this gives insight into the relationship between plasma phenomena and the neutral coma, which is observed by the Comet Pressure Sensor of the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis instrument (ROSINA-COPS).Methods. We use the simple pole expansion technique to compute dispersion relations for waves on ion timescales based on the observed ion distribution functions. These dispersion relations are then compared to the waves that are observed. Data from the instruments RPC-LAP, RPC-ICA and the mutual impedance probe (RPC-MIP) are compared to find the best estimate of the plasma density.Results. We find that ion acoustic waves are present in the plasma at comet 67P/Churyumov-Gerasimenko, where the major ion species is H2O+. The bulk of the ion distribution is cold, k(B)T(i) = 0.01 eV when the ion acoustic waves are observed. At times when the neutral density is high, ions are heated through acceleration by the solar wind electric field and scattered in collisions with the neutrals. This process heats the ions to about 1 eV, which leads to significant damping of the ion acoustic waves.Conclusions. In conclusion, we show that ion acoustic waves appear in the H2O+ plasmas at comet 67P/Churyumov-Gerasimenko and how the interaction between the neutral and ion populations affects the wave properties.
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| 9. |
- Gunell, Herbert, et al.
(författare)
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Plasma waves confined to the diamagnetic cavity of comet 67P/Churyumov-Gerasimenko
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press. - 0035-8711 .- 1365-2966. ; 469, s. S84-S92
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Tidskriftsartikel (refereegranskat)abstract
- Ion acoustic waves were observed in the diamagnetic cavity of comet 67P/Churyumov-Gerasimenko by the Rosetta spacecraft on 2015 August 3, when the comet was 1.25 au from the Sun. Wave spectra recorded by the Langmuir probe (RPC-LAP), peak near 200 Hz, decrease for higher frequencies and reach the noise floor at approximately 1.5 kHz. These waves were observed only when the spacecraft was in the diamagnetic cavity or at its boundary, which is identified as a sharp drop in magnetic field magnitude, measured by RPC-MAG. The plasma, on both sides of the boundary, is dominated by a cold (a few hundred K) water group ion population, one cold (k(B)T(e) similar to 0.1 eV) and one warm (k(B)T(e) similar to 10 eV) electron population. The observations are interpreted in terms of current-driven ion acoustic waves, generated by currents that flow through bulges on the boundary of the diamagnetic cavity.
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| 10. |
- Gunell, H., et al.
(författare)
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Waves in high-speed plasmoids in the magnetosheath and at the magnetopause
- 2014
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 32:8, s. 991-1009
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Tidskriftsartikel (refereegranskat)abstract
- Plasmoids, defined here as plasma entities with a higher anti-sunward velocity component than the surrounding plasma, have been observed in the magnetosheath in recent years. During the month of March 2007 the Cluster spacecraft crossed the magnetopause near the subsolar point 13 times. Plasmoids with larger velocities than the surrounding magnetosheath were found on seven of these 13 occasions. The plasmoids approach the magnetopause and interact with it. Both whistler mode waves and waves in the lower hybrid frequency range appear in these plasmoids, and the energy density of the waves inside the plasmoids is higher than the average wave energy density in the magnetosheath. When the spacecraft are in the magnetosphere, Alfvenic waves are observed. Cold ions of ionospheric origin are seen in connection with these waves, when the wave electric and magnetic fields combine with the Earth's dc magnetic field to yield an E x B/B-2 drift speed that is large enough to give the ions energies above the detection threshold.
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| 11. |
- Li, Kun, et al.
(författare)
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Estimating the Kinetic Energy Budget of the Polar Wind Outflow
- 2018
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 123:9, s. 7917-7929
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Tidskriftsartikel (refereegranskat)abstract
- Ionospheric outflow from the polar cap through the polar wind plays an important role in the evolution of the atmosphere and magnetospheric dynamics. Both solar illumination and solar wind energy input are known to be energy sources of the polar wind. However, observational studies of the energy transfer from these two energy sources to the polar wind are difficult. Because of their low energy, polar wind ions are invisible to regular ion detectors onboard a positively charged spacecraft. Using a new technique that indirectly measures these low-energy ions, we are able to estimate the energy budget of the polar wind. Our results show that solar illumination provides about 10(7) W of the kinetic energy of the polar wind, in addition to the energy transferred from the solar wind with a maximum rate of about 10(8) W. The energy transfer efficiency of solar illumination to the kinetic energy of the polar wind is about 6 to 7 orders of magnitude lower than that of the solar wind. Moreover, daily and seasonal changes in the orientation of the geomagnetic dipole axis control solar illumination over the polar cap, modulating both energies of the polar wind and energy transfer efficiencies from the two energy sources.
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| 12. |
- Maes, L., et al.
(författare)
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Solar Illumination Control of the Polar Wind
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 122:11, s. 11468-11480
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Tidskriftsartikel (refereegranskat)abstract
- Polar wind outflow is an important process through which the ionosphere supplies plasma to the magnetosphere. The main source of energy driving the polar wind is solar illumination of the ionosphere. As a result, many studies have found a relation between polar wind flux densities and solar EUV intensity, but less is known about their relation to the solar zenith angle at the ionospheric origin, certainly at higher altitudes. The low energy of the outflowing particles and spacecraft charging means it is very difficult to measure the polar wind at high altitudes. We take advantage of an alternative method that allows estimations of the polar wind flux densities far in the lobes. We analyze measurements made by the Cluster spacecraft at altitudes from 4 up to 20 RE. We observe a strong dependence on the solar zenith angle in the ion flux density and see that both the ion velocity and density exhibit a solar zenith angle dependence as well. We also find a seasonal variation of the flux density.
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| 13. |
- Maggiolo, R., et al.
(författare)
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Effect of the Surface Roughness of Icy Grains on Molecular Oxygen Chemistry in Molecular Clouds
- 2019
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Ingår i: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 882:2
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Tidskriftsartikel (refereegranskat)abstract
- Molecular cloud and protosolar nebula chemistry involves a strong interaction between the gas phase and the surface of icy grains. The exchanges between the gas phase and the solid phase depend not only on the adsorption and desorption rates but also on the geometry of the surface of the grains. Indeed, for sufficient levels of surface roughness, atoms and molecules have a significant probability to collide with the grain icy mantle several times before being potentially captured. In consequence, their net sticking probability may differ from their sticking probability for a single collision with the grain surface. We estimate the effectiveness of the recapture on uneven surfaces for the various desorption processes at play in astrophysical environments. We show that surface roughness has a significant effect on the desorption rates. We focus in particular on the production of O-2 since unexpectedly large amounts of it, probably incorporated in the comet when it formed, have been detected in the coma of comet 67P by the Rosetta probe. Our results suggest that the higher escape probability of hydrogen compared to heavier species on rough surfaces can contribute to enhancing the production of O-2 in the icy mantles of grains while keeping its abundance low in the gas phase and may significantly decrease the desorption probability of molecules involved in the O-2 chemical network.
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| 14. |
- Maggiolo, R., et al.
(författare)
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The Delayed Time Response of Geomagnetic Activity to the Solar Wind
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 122:11, s. 109-127
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the lagged correlation between a selection of geomagnetic indices and solar wind parameters for a complete solar cycle, from 2000 to 2011. We first discuss the mathematical assumptions required for such a correlation analysis. The solar wind parameters and geomagnetic indices have inherent timescales that smooth the variations of the correlation coefficients with time lag. Furthermore, the solar wind structure associated with corotating interaction regions and coronal mass ejections, and the compression regions ahead of them, strongly impacts the lagged correlation analysis results. This work shows that such bias must be taken into account in a correct interpretation of correlations. We then evidence that the magnetospheric response time to solar wind parameters involves multiple timescales. The simultaneous and quick response of the PC and AE indices to solar wind dynamic pressure with a delay of similar to 5 min suggests that magnetospheric compression by solar wind can trigger substorm activity. We find that the PC and AE indices respond to interplanetary magnetic field (IMF) B-Z with a response time of respectively similar to 20 and similar to 35 min. The response of the SYM-H index takes longer (similar to 80 min) and is less sharp, SYM-H being statistically significantly correlated to the IMF B-Z observed up to more than similar to 10 h before. Our results suggest that the solar wind velocity's dominant impact on geomagnetic activity is caused by the compression regions at the interface of fast/slow solar wind regimes, which are very geo-effective as they are associated with high solar wind pressure and strong interplanetary magnetic field.
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| 15. |
- Maggiolo, R., et al.
(författare)
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The earth's magnetic field enhances solar energy deposition in the upper atmosphere
- 2022
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Ingår i: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 127:12
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Tidskriftsartikel (refereegranskat)abstract
- The presence of a large-scale planetary magnetic field is thought to be a protective factor for atmospheres, preventing them from being blown off by the solar wind. We focus on one key aspect of atmospheric escape: how does a planetary magnetic fields affect the energy transfer from the Sun to the atmosphere? We estimate the solar wind energy currently dissipated in the Earth's atmosphere using empirical formulas derived from observations. We show that it is significantly higher than the energy dissipated in the atmosphere of a hypothetical unmagnetized Earth. Consequently, we conclude that the Earth's magnetic field enhances the solar energy dissipation in the Earth's atmosphere and that, contrary to the old paradigm, an intrinsic magnetic field does not necessarily reduces atmospheric loss.
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| 16. |
- Maggiolo, R., et al.
(författare)
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The Effect of Cosmic Rays on Cometary Nuclei. II. Impact on Ice Composition and Structure
- 2020
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Ingår i: Astrophysical Journal. - : IOP PUBLISHING LTD. - 0004-637X .- 1538-4357. ; 901:2
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Tidskriftsartikel (refereegranskat)abstract
- Since their formation in the protosolar nebula some similar to 4.5 billion years ago, comets are in storage in cold distant regions of the solar system, the Kuiper Belt/scattered disk or Oort Cloud. Therefore, they have been considered as mostly unaltered samples of the protosolar nebula. However, a significant dose of energy is deposited by galactic cosmic rays (GCRs) into the outermost tens of meters of cometary nuclei during their stay in the Oort Cloud or Kuiper Belt. We investigate the impact of energy deposition by GCRs on cometary nuclei. We use experimental results from laboratory experiments and the energy deposition by GCRs estimated by Gronoff et al. (2020), to discuss the depth down to which the cometary nucleus is altered by GCRs. We show that GCRs do not significantly change the isotopic composition of cometary material but modify the chemical composition and the ice structure in the outer layers of the nucleus, which cannot be considered as pristine solar nebula material. We discuss the effect of the collisional history of comets on the distribution of processed material inside the nucleus and its implication on the observation of comets.
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| 17. |
- Pitkänen, Timo, et al.
(författare)
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Response of magnetotail twisting to variations in IMF B-y : a THEMIS case study 1-2 January 2009
- 2016
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Ingår i: Geophysical Research Letters. - : Wiley-Blackwell. - 0094-8276 .- 1944-8007. ; 43:15, s. 7822-7830
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Tidskriftsartikel (refereegranskat)abstract
- Theoretical considerations, observations, and simulations have shown that the B-y component of the interplanetary magnetic field (IMF) may cause twisting of the magnetotail. However, the fundamental issues, the temporal and spatial responses of the magnetotail in the twisting process, are still unresolved. We report unique multipoint observations of the response of the magnetotail to the variations in IMF B-y on 1-2 January 2009. For the first time, estimates of the tail twisting response time at different (Time History of Events and Macroscale Interactions during Substorms, THEMIS) distances in the same event are inferred. Using cross-correlation and timing analyses, we find that the tail twisting propagates from farther out toward the Earth and the response time increases significantly to the inner magnetosphere.
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