| 1. |
- van Bragt, JJMH, et al.
(författare)
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Characteristics and treatment regimens across ERS SHARP severe asthma registries
- 2020
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 55:1
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Tidskriftsartikel (refereegranskat)abstract
- Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m−2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day−1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day−1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.
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| 2. |
- Lønborg, C., et al.
(författare)
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A global database of dissolved organic matter (DOM) concentration measurements in coastal waters (CoastDOM v1)
- 2024
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Ingår i: Earth System Science Data. - : Copernicus Publications. - 1866-3508 .- 1866-3516. ; 16:2, s. 1107-1119
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) concentrations are used to characterize the dissolved organic matter (DOM) pool and are important components ofbiogeochemical cycling in the coastal ocean. Here, we present the first edition of a global database (CoastDOMv1; available at https://doi.org/10.1594/PANGAEA.964012, Lønborg et al., 2023) compiling previously published and unpublished measurements of DOC, DON, and DOP in coastal waters. These data are complementedby hydrographic data such as temperature and salinity and, to the extent possible, other biogeochemical variables(e.g. chlorophyll a, inorganic nutrients) and the inorganic carbon system (e.g. dissolved inorganic carbon andtotal alkalinity). Overall, CoastDOM v1 includes observations of concentrations from all continents. However,most data were collected in the Northern Hemisphere, with a clear gap in DOM measurements from the SouthernHemisphere. The data included were collected from 1978 to 2022 and consist of 62 338 data points for DOC,20 356 for DON, and 13 533 for DOP. The number of measurements decreases progressively in the sequenceDOC > DON > DOP, reflecting both differences in the maturity of the analytical methods and the greater focuson carbon cycling by the aquatic science community. The global database shows that the average DOC concentration in coastal waters (average ± standard deviation (SD): 182±314 µmolC L−1; median: 103 µmolC L−1) is13-fold higher than the average coastal DON concentration (13.6 ± 30.4 µmol N L−1; median: 8.0 µmol N L−1),which is itself 39-fold higher than the average coastal DOP concentration (0.34 ± 1.11 µmol P L−1; median:0.18 µmol P L−1). This dataset will be useful for identifying global spatial and temporal patterns in DOM and willhelp facilitate the reuse of DOC, DON, and DOP data in studies aimed at better characterizing local biogeochemical processes; closing nutrient budgets; estimating carbon, nitrogen, and phosphorous pools; and establishing abaseline for modelling future changes in coastal waters.
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| 5. |
- Contessotto, P., et al.
(författare)
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Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model
- 2023
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study of possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small and large animal models of MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, and hence cater only for an investigation into therapeutics and interventions directed at this subset of MI. Thus, we develop an ovine model of NSTEMI by ligating the myocardial muscle at precise intervals parallel to the left anterior descending coronary artery. Upon histological and functional investigation to validate the proposed model and comparison with STEMI full ligation model, RNA-seq and proteomics show the distinctive features of post-NSTEMI tissue remodelling. Transcriptome and proteome-derived pathway analyses at acute (7 days) and late (28 days) post-NSTEMI pinpoint specific alterations in cardiac post-ischaemic extracellular matrix. Together with the rise of well-known markers of inflammation and fibrosis, NSTEMI ischaemic regions show distinctive patterns of complex galactosylated and sialylated N-glycans in cellular membranes and extracellular matrix. Identifying such changes in molecular moieties accessible to infusible and intra-myocardial injectable drugs sheds light on developing targeted pharmacological solutions to contrast adverse fibrotic remodelling. The study of the pathophysiology and possible interventions for non-ST-segment elevation myocardial infarction is hindered by the lack of a reproducible pre-clinical model. Here, authors develop an ovine model to reproduce post-ischemic remodeling in non-ST myocardial infarction and reveal distinct complex sugar moieties in cellular membranes and extracellular matrix patterns in infarcted tissue.
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| 8. |
- Draganidis, D., et al.
(författare)
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Recovery Kinetics of Knee Flexor and Extensor Strength after a Football Match
- 2015
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 10:6
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Tidskriftsartikel (refereegranskat)abstract
- We examined the temporal changes of isokinetic strength performance of knee flexor (KF) and extensor (KE) strength after a footballmatch. Players were randomly assigned to a control (N = 14, participated only in measurements and practices) or an experimental group (N = 20, participated also in a football match). Participants trained daily during the two days after the match. Match and training overload was monitored with GPS devices. Venous blood was sampled and muscle damage was assessed pre-match, post-match and at 12h, 36h and 60h post-match. Isometric strength as well as eccentric and concentric peak torque of knee flexors and extensors in both limbs (dominant and non-dominant) were measured on an isokinetic dynamometer at baseline and at 12h, 36h and 60h after the match. Functional (KFecc/KEcon) and conventional (KFcon/KEcon) ratios were then calculated. Only eccentric peak torque of knee flexors declined at 60h after the match in the control group. In the experimental group: a) isometric strength of knee extensors and knee flexors declined (P<0.05) at 12h (both limbs) and 36h (dominant limb only), b) eccentric and concentric peak torque of knee extensors and flexors declined (P<0.05) in both limbs for 36h at 60 degrees/s and for 60h at 180 degrees/s with eccentric peak torque of knee flexors demonstrating a greater (P<0.05) reduction than concentric peak torque, c) strength deterioration was greater (P<0.05) at 180 degrees/s and in dominant limb, d) the functional ratio was more sensitive tomatch-induced fatigue demonstrating a more prolonged decline. Discriminant and regression analysis revealed that strength deterioration and recovery may be related to the amount of eccentric actions performed during the match and athletes' football-specific conditioning. Our data suggest that recovery kinetics of knee flexor and extensor strength after a football match demonstrate strength, limb and velocity specificity and may depend on match physical overload and players' physical conditioning level.
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| 10. |
- Kueppers, Michael, et al.
(författare)
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Triple F-a comet nucleus sample return mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 809-847
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Tidskriftsartikel (refereegranskat)abstract
- The Triple F (Fresh From the Fridge) mission, a Comet Nucleus Sample Return, has been proposed to ESA's Cosmic Vision program. A sample return from a comet enables us to reach the ultimate goal of cometary research. Since comets are the least processed bodies in the solar system, the proposal goes far beyond cometary science topics (like the explanation of cometary activity) and delivers invaluable information about the formation of the solar system and the interstellar molecular cloud from which it formed. The proposed mission would extract three sample cores of the upper 50 cm from three locations on a cometary nucleus and return them cooled to Earth for analysis in the laboratory. The simple mission concept with a touch-and-go sampling by a single spacecraft was proposed as an M-class mission in collaboration with the Russian space agency ROSCOSMOS.
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| 13. |
- Poulios, A., et al.
(författare)
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Post-Game High Protein Intake May Improve Recovery of Football-Specific Performance during a Congested Game Fixture: Results from the PRO-FOOTBALL Study
- 2018
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- The effects of protein supplementation on performance recovery and inflammatory responses during a simulated one-week in-season microcycle with two games (G1, G2) performed three days apart were examined. Twenty football players participated in two trials, receiving either milk protein concentrate (1.15 and 0.26 g/kg on game and training days, respectively) (PRO) or an energy-matched placebo (1.37 and 0.31 g/kg of carbohydrate on game and training days, respectively) (PLA) according to a randomized, repeated-measures, crossover, double-blind design. Each trial included two games and four daily practices. Speed, jump height, isokinetic peak torque, and muscle soreness of knee flexors (KF) and extensors (KE) were measured before G1 and daily thereafter for six days. Blood was drawn before G1 and daily thereafter. Football-specific locomotor activity and heart rate were monitored using GPS technology during games and practices. The two games resulted in reduced speed (by 3-17%), strength of knee flexors (by 12-23%), and jumping performance (by 3-10%) throughout recovery, in both trials. Average heart rate and total distance covered during games remained unchanged in PRO but not in PLA. Moreover, PRO resulted in a change of smaller magnitude in high-intensity running at the end of G2 (75-90 min vs. 0-15 min) compared to PLA (P = 0.012). KE concentric strength demonstrated a more prolonged decline in PLA (days 1 and 2 after G1, P = 0.014-0.018; days 1, 2 and 3 after G2, P = 0.016-0.037) compared to PRO (days 1 after G1, P = 0.013; days 1 and 2 after G2, P = 0.014-0.033) following both games. KF eccentric strength decreased throughout recovery after G1 (PLA: P=0.001-0.047-PRO: P =0.004-0.22) in both trials, whereas after G2 it declined throughout recovery in PLA (P = 0.000-0.013) but only during the first two days (P = 0.000-0.014) in PRO. No treatment effect was observed for delayed onset of muscle soreness, leukocyte counts, and creatine kinase activity. PRO resulted in a faster recovery of protein and lipid peroxidation markers after both games. Reduced glutathione demonstrated a more short-lived reduction after G2 in PRO compared to PLA. In summary, these results provide evidence that protein feeding may more efficiently restore football-specific performance and strength and provide antioxidant protection during a congested game fixture.
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| 14. |
- Rago, V., et al.
(författare)
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Contextual Variables and Training Load Throughout a Competitive Period in a Top-Level Male Soccer Team
- 2021
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Ingår i: Journal of Strength and Conditioning Research. - 1064-8011. ; 35:11, s. 3177-3183
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Tidskriftsartikel (refereegranskat)abstract
- Rago, V, Rebelo, A, Krustrup, P, and Mohr, M. Contextual variables and training load throughout a competitive period in a top-level male soccer team. J Strength Cond Res 35(11): 3177-3183, 2021-The aim of the present study was to investigate and quantify the weekly training load (TL) according to different match-related contextual factors in a professional male soccer team (n = 23). Training load was quantified using a 10-Hz global positioning system with integrated 100-Hz accelerometer and heart rate recordings over a 3-month competitive period. Total distance (TD) covered and high-speed running (HSR, >16 km center dot h(-1)) during training were higher in the week after playing against a bottom-level or top-level opponent compared to a medium-level opponent (p < 0.05; effect size [ES] = 0.30-1.04). TD was also higher when preparing for a match against a bottom-level opponent (p < 0.05; ES = 0.39-0.76). In addition, the percentage of HSR was higher after playing a bottom-level compared to a medium-level opponent (p < 0.001; ES = 0.49 [0.27; 0.71]). TD covered was higher in the week following a draw or a win, and higher before a loss compared to a draw (p < 0.05, ES = 0.32-0.81). Both absolute HSR and HSR expressed as percentage of TD were higher before losing and winning a match compared to a draw (p < 0.05; ES = 0.72-0.98). Weekly TL seems to be slightly affected by match-related contextual variables, with special emphasis on the opponent standard and match outcome. Higher training volume was observed before and after playing against a top-level opponent, and after losing a match, whereas the volume of high-intensity training seems to be higher when preparing for a game against a top-level opponent. Future experimental research should clarify the interaction between match-related contextual variables (e.g., cause) and weekly TL (e.g., effect).
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| 15. |
- Rago, V., et al.
(författare)
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Influence of opponent standard on activity profile and fatigue development during preseasonal friendly soccer matches: a team study
- 2018
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Ingår i: Research in Sports Medicine. - : Informa UK Limited. - 1543-8627 .- 1543-8635. ; 26:4, s. 413-424
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Tidskriftsartikel (refereegranskat)abstract
- We examined the influence of competitive standard of the opponent on activity profile and fatigue during preseason friendly soccer matches. Time motion analysis was performed in a male professional soccer team (N=14) during six friendly games played against professional, semi-professional and amateur-level opponents (PL, SPL and AL). The reference team covered higher acceleration distance, acceleration and deceleration 2ms(-2) distance against PL than AL (ES=0.77 to 0.91). Acceleration and deceleration distance 2ms(-2) was also higher (ES=0.66 to 0.84) against SPL than AL. Greater decreases in total distance, distance 16kmh(-1) and >22kmh(-1), total acceleration and deceleration, acceleration and deceleration distance 2ms(-2) (ES=0.84 to 2.20) were also observed during PL compared to AL opponent. Playing against a stronger opponent seems to be more physically demanding, with special emphasis on events related with change of velocity (accelerations and decelerations). Declines in physical performance appear more evident against a higher opponent.
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| 16. |
- Rago, V., et al.
(författare)
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The inter-individual relationship between training status and activity pattern during small-sided and full-sized games in professional male football players
- 2018
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Ingår i: Science and Medicine in Football. - : Informa UK Limited. - 2473-3938 .- 2473-4446. ; 2:2, s. 115-122
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: We analysed the inter-individual relationship between training status and activity pattern in small-sided games (SSG) and full-sized games (FG). Methods: Fourteen Italian elite male senior football players were monitored during four training sessions incorporating SSG, and six FG, during the pre-season. Baseline measurements included, countermovement jump (CMJ), 5-m sprint time and Yo-Yo intermittent recovery test level 1 distance (YYIR1). Activity pattern was collected via 15-Hz global positioning system with 100-Hz accelerometer integrated. Results: Maximum accelerations (Accmax) and maximum decelerations (Decmax) showed moderate correlations (P < 0.05; r = 0.49 and 0.52) between SSG and FG. YYIR1 correlated with total distance covered (TD) in both SSG and FG (P < 0.05; r = 0.42 to 0.57) and with high-intensity distance (HIR) during FG (P < 0.05; r = 0.46 ± 0.38). CMJ showed positive correlations with TD, Accmax, Decmax, total accelerations (Acctot) and total decelerations (Dectot) during FG (P < 0.05; r = 0.40 ± 0.38, 0.41 ± 0.40, 0.46 ± 0.38, 0.65 ± 0.29, 0.57 ± 0.33). Multiple regression analysis revealed Decmax during SSG, as significant predictor of physical performance during FG, explaining a significant amount of variation in HIR, very-high speed running, Accmax and Decmax (P < 0.05; R2 = 0.49, 0.44, 0.26 and 0.49) during FG. Conclusions: SSG seems more effective to enhance muscular efforts occurring during FG, such as accelerations and decelerations, rather than speed patterns. Specifically, Decmax distance imposed during SSG was identified as the predictor of players’ movement patterns during FG. Thus, importance of eccentric strength (i.e. imposed when decelerating) to achieve football-specific fitness is emphasised. These findings may assist coaches and any football practitioners for pre-season programming. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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| 17. |
- Rago, V., et al.
(författare)
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Training load and submaximal heart rate testing throughout a competitive period in a top-level male football team
- 2020
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Ingår i: Journal of Sports Sciences. - : Informa UK Limited. - 0264-0414 .- 1466-447X. ; 38:11-12, s. 1408-1415
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate training load and cardiorespiratory fitness in a top-level Spanish (LaLiga) football team (n = 17). The submaximal Yo-Yo intermittent recovery test level 1 (Yo-Yo IR1(SUB)) was performed in four moments of the competitive period from early February (E1) to early May (E4). Training load was quantified using a 10-Hz global positioning system and heart rate (HR) recording (n = 837 individual training sessions), while match load was quantified using semi-automated cameras (n = 216 individual match observations). Cardiorespiratory fitness moderately improved as the season progressed (P < 0.05; effect sizes = 0.8 to 1.2). Cumulative total distance covered during training between E1 and E4 was negatively correlated with percentage of changes in mean HR during the last 30 s of Yo-Yo IR1(SUB) (P = 0.049; r = -0.47 [-0.71; -0.14]; moderate). HR during the last 30 s of Yo-Yo IR1(SUB) was negatively correlated to total distance covered during the match (P = 0.024; r = -0.56 [-0.80; -0.17]; moderate). Yo-Yo IRSUB can be used to monitor seasonal changes in cardiorespiratory fitness without the need to have players work until exhaustion. Cardiorespiratory fitness given by mean HR during the last 30 s of the test seems meaningful in relation to match performance.
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