| 1. |
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| 2. |
- Magnusson, Peetra, et al.
(författare)
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Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development
- 2004
-
Ingår i: Journal of Cell Science. - : The Company of Biologists. - 0021-9533 .- 1477-9137. ; 117:Pt 8, s. 1513-1523
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Tidskriftsartikel (refereegranskat)abstract
- We have employed embryoid bodies derived from murine embryonal stem cells to study effects on vascular development induced by fibroblast growth factor (FGF)-2 and FGF receptor-1, in comparison to the established angiogenic factor vascular endothelial growth factor (VEGF)-A and its receptor VEGF receptor-2. Exogenous FGF-2 promoted formation of morphologically distinct, long slender vessels in the embryoid bodies, whereas VEGF-A-treated bodies displayed a compact plexus of capillaries. FGF-2 stimulation of embryonal stem cells under conditions where VEGF-A/VEGFR-2 function was blocked, led to formation of endothelial cell clusters, which failed to develop into vessels. FGFR-1(-/-) embryoid bodies responded to VEGF-A by establishment of the characteristic vascular plexus, but FGF-2 had no effect on vascular development in the absence of FGFR-1. The FGFR-1(-/-) embryoid bodies displayed considerably increased basal level of vessel formation, detected by immunohistochemical staining for platelet-endothelial cell adhesion molecule (PECAM)/CD31. This basal vascularization was blocked by neutralizing antibodies against VEGFR-2 or VEGF-A and biochemical analyses indicated changes in regulation of VEGFR-2 in the absence of FGFR-1 expression. We conclude that VEGF-A/VEGFR-2-dependent vessel formation occurs in the absence of FGF-2/FGFR-1, which, however, serve to modulate vascular development.
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| 3. |
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| 4. |
- Olsson, Anne-Charlotte, et al.
(författare)
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Jämförelse mellan järntilldelning via injektion alternativt järntorv (Torvojärn Extra) till smågrisar
- 2018
-
Ingår i: LTV-fakultetens faktablad.
-
Annan publikation (populärvet., debatt m.m.)abstract
- Grisar föds med en begränsad mängd järn och grisar som inte har tillgång till jord att böka i, måste ges järntillskott för att förebygga anemi och dålig tillväxt. Detta järntillskott kan ges på olika sätt. För att undersöka grisars järnstatus analyseras oftast blodets hemoglobinvärde (Hb). Värden kring 100-120 g/l anses normala, men rekommendationerna varierar. Att enbart använda Hb-värde som bedömningsgrund för grisens järnstatus är också något som kritiseras. Syftet i denna studie har varit att jämföra tillväxt och blodvärden (Hb) hos grisar som tilldelats järn antingen via injektion eller via produkten TorvoJärn Extra (Lantmännen Lantbruk). Tillväxt och Hb- värden hos tre grisar per kull (liten, medel och stor vid födelsen) har undersökts. Det konkluderas att resultaten genomgående visade på något lägre Hb-värden vid järntilldelning via TorvoJärn Extra jämfört med vid tilldelning av järn via injektion. För små och medelstora grisar kunde dock ingen signifikant negativ effekt på tillväxten av detta påvisas. För kategorin ”stora grisar” registrerades däremot en tendens (p=0,098) till något sämre tillväxt från födelse till utflyttning ur tillväxtavdelningen då grisarna inte fick järninjektion.
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| 5. |
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| 6. |
- Salihovic, Samira, Associate Senior Lecturer, 1985-, et al.
(författare)
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Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
- 2024
-
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.
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| 7. |
- Salihovic, Samira, Associate Senior Lecturer, 1985-, et al.
(författare)
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Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
- 2024
-
Ingår i: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-na & iuml;ve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making. Diagnostic blood-based biomarkers of pediatric IBD are limited. Here, the authors demonstrate a diagnostic lipidomic signature, comprising only of two molecular lipids. Translation of this signature into a scalable test has the potential to support clinical decision making.
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| 8. |
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| 9. |
- Brady, Alan C, et al.
(författare)
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Discrimination of tactile rendering on virtual surfaces
- 2006
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Ingår i: ; , s. 107-108
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Konferensbidrag (refereegranskat)abstract
- An array of vibrating contactors on the fingertip can provide information about virtual objects during active exploration of a virtual environment – for example, information about contact area, edges, corners and surface texture. For the operation of such a device, it is necessary to generate in real time an individually specified drive waveform for each contactor of the stimulator array. To reduce the complexity of the problem, a system has been developed at Exeter in which each drive signal is specified as a mixture of a small number of sinewaves. The aim of this study is to investigate the discrimination of the virtual textures which can be produced in this way, with the aim of developing a library of textures for use in virtual reality applications. Textures produced by mixtures of sinewaves are differentiated in terms of the mean amplitude and the spatial distribution at each sinewave frequency. Experimental questions include the number of categories (i.e., requency/amplitude/spatial combinations) that can be distinguished and the possible correspondence between virtual and real textures.
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| 10. |
- Böttcher, Johanna, et al.
(författare)
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Adding a smartphone app to internet-based self-help for social anxiety : A randomized controlled trial
- 2018
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Ingår i: Computers in human behavior. - : Elsevier BV. - 0747-5632 .- 1873-7692. ; 87, s. 98-108
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Tidskriftsartikel (refereegranskat)abstract
- Background: Increasing access to treatment via smartphone apps is an important topic in Social Anxiety Disorder (SAD). ‘Challenger’ is an app promoting exposure exercises in daily life. The present study evaluated the additional benefit of using the app as adjunct to Internet-based unguided self-help for SAD. In a second step, we also tested how the app and the self-help programme (SH) should best be combined.Method: 209 patients diagnosed with SAD were randomly allocated to three groups. Group 1 received the app and the self-help programme for six weeks (parallel treatment), group 2 first received SH for six weeks and then the app for six weeks (sequential treatment). Group 3 was a wait-list group. Comparisons were made at week 7 evaluating the potential add-on effect of the app (SH plus app versus SH only) and at week 14 comparing the parallel to the sequential treatment. Participants filled in questionnaires prior, during, and post treatment, and at 4- and 12- months follow-up.Results: Intention-to-treat analyses showed no significant effect of adding the app to Internet-based self-help. However, among participants actively using the app, adding Challenger to self-help resulted in significantly less social anxiety (d = 0.30). At week 14, decreases in social anxiety were large for both the parallel and the sequential group with no differences between the active groups (dwithin = 1.12–1.19). Changes were maintained throughout the follow-up period.Conclusion: Results of the current study cautiously support the notion of adding a smartphone app to unguided self-help for SAD. Future studies should investigate how patients can be motivated to use the app more frequently.
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| 11. |
- Caltenco, Héctor A., et al.
(författare)
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Designing interactive systems for balance rehabilitation after stroke
- 2017
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Ingår i: TEI 2017 - Proceedings of the 11th International Conference on Tangible, Embedded, and Embodied Interaction. - New York, NY, USA : ACM. - 9781450346764 ; , s. 511-516
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Konferensbidrag (refereegranskat)abstract
- This paper presents four different tangible interactive prototypes designed to support the continuation of balance rehabilitation at home. The interactive prototypes are designed to provide a more enjoyable and experience when performing balance rehabilitation exercises. Early results from preliminary tests with stroke survivors and rehabilitation professionals are promising. The aim of the designs is to allow people at different levels of rehabilitation to engage into balance training and perform the exercises according to their current skills.
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| 12. |
- Caltenco, Héctor, et al.
(författare)
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Co-designing wearable technology together with visually impaired children
- 2016
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Ingår i: International Journal of Mobile Human Computer Interaction. - 1942-390X. ; 8:4, s. 68-84
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the process and results of a set of studies within the ABBI EU project, with the general aim to co-design wearable technology (an audio bracelet) together with visually impaired children, starting at a young age. The authors discuss user preferences related to sounds and tactile materials and present the results of a focus group with very young visually-impaired children under the age of 5, together with their parents. They find that multisensory feedback (visual, tactile/haptic, auditory) is useful and that preferences vary - also the drastic and potentially unpleasant sounds and materials may have a role. Further studies investigate the possibilities of using the ABBI wearable technology for social contexts and games. In a series of game workshops children with and without visual impairments created games with wearable technology employing very simple interactivity. The authors report the created games, and note that even with this simple interactivity it is possible to create fun, inclusive and rich socially co-located games.
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| 13. |
- Caltenco, Héctor, et al.
(författare)
-
Co-Designing wearable technology together with visually impaired children
- 2018
-
Ingår i: Wearable Technologies : Concepts, Methodologies, Tools, and Applications - Concepts, Methodologies, Tools, and Applications. - : IGI Global. - 9781522554851 - 152255484X - 9781522554844 ; , s. 314-332
-
Bokkapitel (refereegranskat)abstract
- This paper presents the process and results of a set of studies within the ABBI EU project, with the general aim to co-design wearable technology (an audio bracelet) together with visually impaired children, starting at a young age. The authors discuss user preferences related to sounds and tactile materials and present the results of a focus group with very young visually-impaired children under the age of 5, together with their parents. They find that multisensory feedback (visual, tactile/haptic, auditory) is useful and that preferences vary - also the drastic and potentially unpleasant sounds and materials may have a role. Further studies investigate the possibilities of using the ABBI wearable technology for social contexts and games. In a series of game workshops children with and without visual impairments created games with wearable technology employing very simple interactivity. The authors report the created games, and note that even with this simple interactivity it is possible to create fun, inclusive and rich socially co-located games.
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| 14. |
- Casas Garcia, Belén, et al.
(författare)
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Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research
- 2022
-
Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 17:10
-
Tidskriftsartikel (refereegranskat)abstract
- Microphysiological systems (MPS) are powerful tools for emulating human physiology and replicating disease progression in vitro. MPS could be better predictors of human outcome than current animal models, but mechanistic interpretation and in vivo extrapolation of the experimental results remain significant challenges. Here, we address these challenges using an integrated experimental-computational approach. This approach allows for in silico representation and predictions of glucose metabolism in a previously reported MPS with two organ compartments (liver and pancreas) connected in a closed loop with circulating medium. We developed a computational model describing glucose metabolism over 15 days of culture in the MPS. The model was calibrated on an experiment-specific basis using data from seven experiments, where HepaRG single-liver or liver-islet cultures were exposed to both normal and hyperglycemic conditions resembling high blood glucose levels in diabetes. The calibrated models reproduced the fast (i.e. hourly) variations in glucose and insulin observed in the MPS experiments, as well as the long-term (i.e. over weeks) decline in both glucose tolerance and insulin secretion. We also investigated the behaviour of the system under hypoglycemia by simulating this condition in silico, and the model could correctly predict the glucose and insulin responses measured in new MPS experiments. Last, we used the computational model to translate the experimental results to humans, showing good agreement with published data of the glucose response to a meal in healthy subjects. The integrated experimental-computational framework opens new avenues for future investigations toward disease mechanisms and the development of new therapies for metabolic disorders.
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| 15. |
- Eftring, Håkan, et al.
(författare)
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Capturing better data: The potential for better insight into user's requirements through iterative prototyping
- 1995
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Ingår i: UserTalk. ; :6, s. 4-5
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Tidskriftsartikel (refereegranskat)abstract
- This article aims at introducing to a wider circle a complementary research approach in user oriented work. Its most fundamental part is the use of technology as a tool for capturing the needs, wishes and dreams of a user. The incitement for us to start developing this method was an experience based, serious, questioning of conventional methods such as interviews, questionnaires, etc, and their capability of revealing user requirements without the users and the researchers being familiar with the technology in question. Mental models developed through iterative prototyping is a key factor in our approach. We consider it necessary to focus on the mental models of the user as well as of the researcher, and on the interference between these models. Unless they produce similar predictions and observable results, their value is limited.
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| 16. |
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| 17. |
- Elam, Cecilia, et al.
(författare)
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Effects of age on muscle power, postural control and functional capacity after short-term immobilization and retraining.
- 2022
-
Ingår i: Journal of musculoskeletal & neuronal interactions. - 1108-7161. ; 22:4, s. 486-497
-
Tidskriftsartikel (refereegranskat)abstract
- This study investigated the effect of lower limb immobilization and retraining on postural control and muscle power in healthy old and young men.Twenty men, nine old (OM:67.3±4.4 years) and eleven young (YM:24.4±1.6 years) underwent 2 weeks of unilateral whole-leg casting, followed by 4 weeks of retraining. Measures included center of pressure (CoP) sway length and area during single- and double-leg stance, maximal leg extensor muscle power, habitual and maximal 10-m gait speed, sit-to-stand performance, and 2-min step test.After immobilization, leg extension muscle power decreased by 15% in OM (from 2.68±0.60 to 2.29±0.63 W/kg, p<0.05) and 17% in YM (4.37±0.76 to 3.63±0.69 W/kg, p<0.05). Double-leg CoP sway area increased by 45% in OM (218±82 to 317±145 mm2; p<0.05), with no change in YM (p=0.43). Physical function did not change after immobilization but sit-to-stand performance (+20%, p<0.05) and 2-min step test (+28%, p<0.05) increased in OM following retraining. In both groups, all parameters returned to baseline levels after retraining.Two weeks of lower limb immobilization led to decreases in maximal muscle power in both young and old, whereas postural control was impaired selectively in old men. All parameters were restored in both groups after 4 weeks of resistance-based retraining.
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| 18. |
- Ernberg, Emelie, 1989, et al.
(författare)
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Swedish Courts’ Evaluations of Interpreter-Mediated Child Investigative Interviews
- 2023
-
Ingår i: Child Maltreatment. - : SAGE Publications. - 1077-5595 .- 1552-6119. ; 28:3
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Tidskriftsartikel (refereegranskat)abstract
- Children can need the help of an interpreter if they are victims of a crime and need to be forensically interviewed in another language. Recent findings from practitioners raise concerns about the state of interpreter-mediated interviews with children. The current study aimed to explore how Swedish criminal courts reason when assessing interpreter-mediated and interpreter-absent (with children who are not fluent in Swedish) child investigative interviews. We conducted qualitative and descriptive analyses of written court verdicts involving 108 child victims who were evaluated to need an interpreter during their investigative interview. The courts frequently discussed issues regarding possible misinterpretations, language difficulties, and confusion. These perceived deficiencies in the interviews were often mentioned as a cause for assessing the child’s testimony with caution and, in some cases, as lowering the evidential value of the child interview. Possible implications for children’s legal rights are discussed.
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| 19. |
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| 20. |
- Freeman, Euan, et al.
(författare)
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Audible beacons and wearables in schools : Helping young visually impaired children play and move independently
- 2017
-
Ingår i: CHI 2017 - Proceedings of the 2017 ACM SIGCHI Conference on Human Factors in Computing Systems : Explore, Innovate, Inspire - Explore, Innovate, Inspire. - New York, NY, USA : ACM. - 9781450346559 ; 2017-May, s. 4146-4157
-
Konferensbidrag (refereegranskat)abstract
- Young children with visual impairments tend to engage less with their surroundings, limiting the benefits from activities at school. We investigated novel ways of using sound from a bracelet, such as speech or familiar noises, to tell children about nearby people, places and activities, to encourage them to engage more during play and help them move independently. We present a series of studies, the first two involving visual impairment educators, that give insight into challenges faced by visually impaired children at school and how sound might help them. We then present a focus group with visually impaired children that gives further insight into the effective use of sound. Our findings reveal novel ways of combining sounds from wearables with sounds from the environment, motivating audible beacons, devices for audio output and proximity estimation. We present scenarios, findings and a design space that show the novel ways such devices could be used alongside wearables to help visually impaired children at school.
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| 21. |
- Globisch, Maria A., et al.
(författare)
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Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation
- 2022
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 140:20, s. 2154-2169
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral cavernous malformation (CCM) is a neurovascular disease that results in various neurological symptoms. Thrombi have been reported in surgically resected CCM patient biopsies, but the molecular signatures of these thrombi remain elusive. Here, we investigated the kinetics of thrombi formation in CCM and how thrombi affect the vasculature and contribute to cerebral hypoxia. We used RNA sequencing to investigate the transcriptome of mouse brain endothelial cells with an inducible endothelial-specific Ccm3 knock-out (Ccm3-iECKO). We found that Ccm3-deficient brain endothelial cells had a higher expression of genes related to the coagulation cascade and hypoxia when compared with wild-type brain endothelial cells. Immunofluorescent assays identified key molecular signatures of thrombi such as fibrin, von Willebrand factor, and activated platelets in Ccm3-iECKO mice and human CCM biopsies. Notably, we identified polyhedrocytes in Ccm3-iECKO mice and human CCM biopsies and report it for the first time. We also found that the parenchyma surrounding CCM lesions is hypoxic and that more thrombi correlate with higher levels of hypoxia. We created an in vitro model to study CCM pathology and found that human brain endothelial cells deficient for CCM3 expressed elevated levels of plasminogen activator inhibitor-1 and had a redistribution of von Willebrand factor. With transcriptomics, comprehensive imaging, and an in vitro CCM preclinical model, this study provides experimental evidence that genes and proteins related to the coagulation cascade affect the brain vasculature and promote neurological side effects such as hypoxia in CCMs. This study supports the concept that antithrombotic therapy may be beneficial for patients with CCM.
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| 22. |
- Hamamoto, Ikuko, et al.
(författare)
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Deformation dependence of magnetic dipole strength below 4 MeV in doubly even rare earth nuclei
- 1991
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Ingår i: Physics Letters B. - 0370-2693. ; 260:1-2, s. 6-10
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Tidskriftsartikel (refereegranskat)abstract
- We show: (1) In the presence of the pair correlation the M1 transition strength calculated in the deformed oscillator model has a dependence on the quadrupole deformation parameter δ which is considerably stronger than linear and, in fact, it varies quadratically with δ in the limit of small deformation; (2) The deformation dependence in samarium isotopes calculated using the quasiparticle random phase approximation (QRPA) reproduces the qualitative behaviour of the recent experimental data of Ziegler, Rangacharyulu, Richter and Spieler.
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| 23. |
- Hamamoto, Ikuko, et al.
(författare)
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Form-factor of low-lying Kπ=1+ excitations in rare-earth nuclei
- 1987
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 194:1, s. 6-10
-
Tidskriftsartikel (refereegranskat)abstract
- The differential cross section of inelastic electron scattering for the low-lying “collective” Kπ=1+ excitations in rare-earth nuclei is calculated in DWBA by using microscopically calculated transition-densities. In the region of low-momentum transfer (q⪅0.5 fm-1) in which experimental data are available the shape of calcualted cross sections is almost the same for all nuclei and is slightly but systematically different from the observed shape.
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| 24. |
- Harrison, Dick, et al.
(författare)
-
Vikingatidens Europa
- 2018
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Ingår i: Birkas skepp : vikingatid på Östersjön - vikingatid på Östersjön. - 0349-019X. - 9789173291316 ; 2018/2019, s. 10-49
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Bokkapitel (refereegranskat)
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| 25. |
- Huang, Ying Ying, 1976-
(författare)
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Design and Evaluation of 3D Multimodal Virtual Environments for Visually Impaired People
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Spatial information presented visually is not easily accessible to visually impairedusers. Current technologies, such as screen readers, cannot intuitively conveyspatial layout or structure. This lack of overview is an obstacle for a visuallyimpaired user, both when using the computer individually and when collaboratingwith other users. With the development of haptic and audio technologies, it ispossible to let visually impaired users access to three-dimensional (3D) VirtualReality (VR) environments through the senses of touch and hearing.The work presented in this thesis comprises investigations of haptic and audiointeraction for visually impaired computer users in two stages.The first stage of my research focused on collaborations between sighted andblind-folded computer users in a shared virtual environment. One aspect Iconsidered is how different modalities affect one’s awareness of the other’sactions, as well as of one’s own actions, during the work process. The secondaspect I investigated is common ground, i.e. how visually impaired people obtaina common understanding of the elements of their workspace through differentmodalities. A third aspect I looked at was how different modalities affectperceived social presence, i.e. their ability to perceive the other person’sintentions and emotions. Finally, I attempted to understand how human behaviorand efficiency in task performance are affected when different modalities are usedin collaborative situations.The second stage of my research focused on how the visually impaired access3D multimodal virtual environment individually. I conducted two studies basedon two different haptic and audio prototypes concerning understanding the effectof haptic-audio modalities on navigation and interface design. One prototype thatI created was a haptic and audio game, a labyrinth. The other is a virtualsimulation environment based on the real world of Kulturhuset in Stockholm. Oneaspect I investigated in this individual interaction is how it is possible for users toaccess the spatial layout through a multimodal virtual environment. The secondaspect I investigated is usability; how the haptic and audio cues help visuallyimpaired people understand the spatial layout. The third aspect concernsnavigation and cognitive mapping in a multimodal virtual environment.This thesis contributes to the field of human-computer interaction for thevisually impaired with a set of studies of multimodal interactive systems, andbrings new perspectives to the enhancement of understanding real environmentsfor visually impaired users through a haptic and audio virtual computerenvironment.
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| 26. |
- Hultman, Elin, et al.
(författare)
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Vulnerable children's health as described in investigations of reported children
- 2013
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Ingår i: Child & Family Social Work. - : Wiley-Blackwell. - 1356-7500 .- 1365-2206. ; 18:2, s. 117-128
-
Tidskriftsartikel (refereegranskat)abstract
- This study explores whether the social services weigh in health aspects, and what these may be, when investigating reported childrens life situation. Information about physical and psychological health aspects for 259 children in 272 investigations was included. Overall, information about childrens health was limited. Problematic emotions were the most commonly reported health aspect in the investigations, whereas suicidal thoughts, self-harm behaviour and gastrointestinal and renal diseases were mentioned least of all. A cluster analysis revealed that the low level of health information group included the largest sample of data and consisted of investigations with minimal information about childrens health. The three other cluster groups, Neurological diseases and psychosomatic symptoms, Emotional health and Physical and psychological health and destructive behaviour, consisted of investigations conducted mostly according to the model called Childrens Needs In Focus (BBIC, in Swedish, Barns Behov i Centrum). Although these investigations also produced limited information, they provided more than those assessed as having a low level of information about health aspects. The conclusion is that it is necessary to increase information about health aspects in investigations if social welfare systems are to be able to fulfil their ambition of supporting vulnerable childrens need of health care.
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| 27. |
- Immerstrand, Charlotte, 1974-, et al.
(författare)
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Altered impedance during pigment aggregation in Xenopus laevis melanophores
- 2003
-
Ingår i: Medical and Biological Engineering and Computing. - 0140-0118 .- 1741-0444. ; 41:3, s. 357-364
-
Tidskriftsartikel (refereegranskat)abstract
- Melanophores are dark-brown pigment cells located in the skin of amphibia, fish and many invertebrates. The skin colour of these organisms is regulated by the translocation of pigment organelles, and the pigment distribution can be altered by external stimuli. The ability to change colour in response to stimuli makes these cells of interest for biosensing applications. It was investigated whether pigment aggregation in Xenopus laevis melanophores can be detected by impedance measurements performed in transparent microvials. The results show that cell attachment, cell spreading and pigment aggregation all resulted in impedance changes, seen particularly at the highest frequency tested (10 kHz). The mechanisms behind the impedance changes were investigated by the addition of latrunculin or melatonin, both of which cause pigment aggregation. The latrunculin-induced aggregation was associated with cell area decrease and filamentous actin (F-actin) breakdown, processes that can influence the impedance. Lack of F-actin breakdown and an increase in cell area during melatonin-induced aggregation suggest that some other intracellular process also contributes to the impedance decrease seen for melatonin. It was shown that impedance measurements reflect not only cell attachment and cell spreading, but also intracellular events.
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| 28. |
- Immerstrand, Charlotte, et al.
(författare)
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Conjugated-polymer micro- and milliactuators for biological applications
- 2002
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Ingår i: MRS bulletin. - : Springer Science and Business Media LLC. - 0883-7694 .- 1938-1425. ; 27:6, s. 461-464
-
Tidskriftsartikel (refereegranskat)abstract
- The development of new conjugated-polymer tools for the study of the biological realm, and for use in a clinical setting, is reviewed in this article. Conjugated-polymer actuators, based on the changes of volume of the active conjugated polymer during redox transformation, can be used in electrolytes employed in cell-culture media and in biological fluids such as blood, plasma, and urine. Actuators ranging in size from 10 μm to 100 μm suitable for building structures to manipulate single cells are produced with photolithographic techniques. Larger actuators may be used for the manipulation of blood vessels and biological tissue.
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| 29. |
- Immerstrand, Charlotte, 1974-, et al.
(författare)
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Height changes associated with pigment aggregation in Xenopus laevis melanophores
- 2004
-
Ingår i: Bioscience Reports. - : Portland Press Ltd.. - 0144-8463 .- 1573-4935. ; 24:3, s. 203-214
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Tidskriftsartikel (refereegranskat)abstract
- Melanophores are pigment cells found in the skin of lower vertebrates. The brownish-black pigment melanin is stored in organelles called melanosomes. In response to different stimuli, the cells can redistribute the melanosomes, and thereby change colour. During melanosome aggregation, a height increase has been observed in fish and frog melanophores across the cell centre. The mechanism by which the cell increases its height is unknown. Changes in cell shape can alter the electrical properties of the cell, and thereby be detected in impedance measurements. We have in earlier studies of Xenopus laevis melanophores shown that pigment aggregation can be revealed as impedance changes, and therefore we were interested in investigating the height changes associated with pigment aggregation further. Accordingly, we quantified the changes in cell height by performing vertical sectioning with confocal microscopy. In analogy with theories explaining the leading edge of migrating cells, we investigated the possibility that the elevation of plasma membrane is caused by local swelling due to influx of water through HgC12-sensitive aquaporins. We also measured the height of the microtubule structures to assess whether they are involved in the height increase. Our results show that pigment aggregation in X. laevis melanophores resulted in a significant height increase, which was substantially larger when aggregation was induced by latrunculin than with melatonin. Moreover, the elevation of the plasma membrane did not correlate with influx of water through aquaporins or formation of new microtubules, Rather, the accumulation of granules seemed to drive the change in cell height.
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| 30. |
- Immerstrand, Charlotte, et al.
(författare)
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Image correlation spectroscopy for quantification of pigment aggregation
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In the skin of amphibia, fish, and other organisms, the distribution of the pigment granules within melanophores regulates skin colour. In this study we have applied Image Correlation Spectroscopy (ICS; Petersen et al. 1998; Petersen et al. 1993) to monitor the aggregation of pigment granules. Normally in ICS, images from confocallaser scanning rnicroscopy are used to calculate autocorrelation functions from which the density of fluorescent particles in the image, like membrane receptors, can be obtained. The present study differs from traditional ICS in that the images are obtained by light microscopy and then Gaussian filtered to give the particles the appropriate intensity profile required for ICS analysis. ICS appears to be more sensitive than particle counting and image mean intensity for quantification of the degree of pigment aggregation. This study demonstrates for the first time that ICS can be used to analyse the aggregation of non-fluorescent particles, such as pigment granules in Xenopus laevis melanophores.
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| 31. |
- Immerstrand, Charlotte, 1974-, et al.
(författare)
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Organelle transport in melanophores analyzed by white light image correlation spectroscopy
- 2007
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Ingår i: Journal of Microscopy. - : Wiley. - 0022-2720 .- 1365-2818. ; 225:3, s. 275-282
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Tidskriftsartikel (refereegranskat)abstract
- Intracellular transport of organelles, vesicles and proteins is crucial in all eukaryotic cells, and is accomplished by motor proteins that move along cytoskeletal filaments. A widely used model of intracellular transport is Xenopus laevis melanophores. These cells help the frog to change color by redistributing melanin-containing organelles in the cytoplasm. The high contrast of the pigment organelles permits changes in distribution to be observed by ordinary light microscopy; other intracellular transport systems often require fluorescence labeling. Here we have developed white light Image Correlation Spectroscopy (ICS) to monitor aggregation and dispersion of pigment. Hitherto in ICS, images of fluorescent particles from Confocal Laser Scanning Microscopy (CLSM) have been used to calculate autocorrelation functions from which the density can be obtained. In the present study we show that ICS can be modified to enable analysis of light-microscopy images; it can be used to monitor pigment aggregation and dispersion, and distinguish between different stimuli. This new approach makes ICS applicable not only to fluorescent but also to black-and-white images from light or electron microscopy, and is thus very versatile in different studies of movement of particles on the membrane or in the cytoplasm of cells without potentially harmful fluorescence labeling and activation.
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| 32. |
- Innala Ahlmark, Daniel
(författare)
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Haptic Navigation Aids for the Visually Impaired
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Assistive technologies have improved the situation in society for visually impaired individuals.The rapid development the last decades have made both work and education much more accessible. Despite this, moving about independently is still a major challenge, one that at worst can lead to isolation and a decreased quality of life. To aid in the above task, devices exist to help avoid obstacles (notably the white cane), and navigation aids such as accessible GPS devices. The white cane is the quintessential aid and is much appreciated, but solutions trying to convey distance and direction to obstacles further away have not made a big impact among the visually impaired. Onefundamental challenge is how to present such information non-visually. Sounds and synthetic speech are typically utilised, but feedback through the sense of touch (haptics) is also used, often in the form of vibrations. Haptic feedback is appealing because it does not block or distort sounds from the environment that are important for non-visual navigation. Additionally, touch is a natural channel for information about surrounding objects, something the white cane so successfully utilises. This doctoral thesis explores the question above by presenting the development and evaluations of dierent types of haptic navigation aids. The goal has been to attain a simple user experience that mimics that of the white cane. The idea is that a navigation aid able to do this should have a fair chance of being successful on the market. Theevaluations of the developed prototypes have primarily been qualitative, focusing on judging the feasibility of the developed solutions. They have been evaluated at a very early stage, with visually impaired study participants.Results from the evaluations indicate that haptic feedback can lead to solutions that are both easy to understand and use. Since the evaluations were done at an early stage in the development, the participants have also provided valuable feedback regarding design and functionality. They have also noted many scenarios throughout their daily lives where such navigation aids would be of use.The thesis document these results, together with ideas and thoughts that have emerged and been tested during the development process. This information contributes to the body of knowledge on dierent means of conveying information about surrounding objects non-visually.
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| 33. |
- Innala Ahlmark, Daniel
(författare)
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The Development of a Virtual White Cane Using a Haptic Interface
- 2014
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- For millions of visually impaired individuals worldwide, independent navigation is a major challenge. The white cane can be used to avoid obstacles close-by, but it does not aid in navigation as it is difficult to get a large-scale view of the environment. Technological aids have been developed, notably ones based on GPS, but they have not been widely adopted. This thesis approaches the problem from different perspectives. Firstly, current navigation aids are examined from a user-interaction perspective, leading to some design guidelines on how to present spatial information non-visually. Secondly, a prototype of a new navigation aid (the Virtual White Cane) is proposed, and a field trial with visually impaired participants is described. The idea behind the Virtual White Cane is to utilise the intuitive way humans avoid obstacles by touch, and specifically to leverage the experience white cane users already have. This is accomplished by scanning the environment with a laser rangefinder, and presenting the range information using a haptic interface. The regular white cane is easy to use because it behaves like an extended arm, and so does the Virtual White Cane, albeit working at a much greater distance than the regular cane. A field trial with six experienced white cane users was conducted to assess the feasibility of this kind of interaction. The participants carried out a trial procedure where they traversed a prepared environment using the Virtual White Cane. They did not receive extensive training prior to the trial, the point being that if the Virtual White Cane behaves like a regular one, it should be quick to learn for a white cane user. The results show that spatial information can be feasibly conveyed using a haptic interface. This is demonstrated by the ease with which the field trial participants familiarised themselves with the system, notably adopting a similar usage pattern. In interviews that were conducted following the trial procedures, the participants expressed interest in the idea and thought that being a white cane user helped them use the Virtual White Cane. Despite knowing how to operate the system, the participants found locating objects to be difficult. An extended training period would likely have made this easier, but this problem could also be lessened by understanding what model parameters (such as the length of the virtual cane) should be used.
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| 34. |
- Jager, Edwin, et al.
(författare)
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Biomedical applications of polypyrrole microactuators : from single-cell clinic to microrobots
- 2000
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Ingår i: 1st Annual International, Conference On Microtechnologies in Medicine and Biology. 2000. - : IEEE. - 0780366034 ; , s. 58-61
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Microtools that will be useful for the positioning and investigation microstructures must operate relevant environments, such as cell culture media or blood plasma. They must also be comparatively strong, and preferably allow a muscle like mode of movement. This is given by a novel family of actuators based on conjugated polymers (like polypyrrole, PPy). By miniaturising these structures using standard photolithographic techniques, the authors can reduce the size down to 10-micrometer dimensions and build mechanically active microdevices. These can be moved and positioned by applying a potential to dope or undope the PPy. These novel structures are now being developed as a unique microactuator technology, suitable for operation in applications coupled to cell biology and biomedicine
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| 35. |
- Jager, Edwin W.H., et al.
(författare)
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The cell clinic : closable microvials for single cell studies
- 2002
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Ingår i: Biomedical microdevices (Print). - 1387-2176 .- 1572-8781. ; 4:3, s. 177-187
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Tidskriftsartikel (refereegranskat)abstract
- We present the development of a cell clinic. This is a micromachined cavity, or microvial, that can be closed with a lid. The lid is activated by two polypyrrole/Au microactuators. Inside the microvials two Au electrodes have been placed in order to perform impedance studies on single or a small number of cells. We report on impedance measurements on Xenopus leavis melanophores. We could measure a change in the impedance upon cell spreading and identify intracellular events such as the aggregation of pigment granules. The electrical data is correlated to optical microscopy.
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| 36. |
- Jönsson, Bodil, et al.
(författare)
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Rehabiliteringsteknisk forskning
- 1995
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Ingår i: Socialmedicinsk tidskrift. - 0037-833X. ; 72:6-7, s. 224-230
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Tidskriftsartikel (refereegranskat)abstract
- Föreliggande artikel söker presentera det vida området (re)habiliterings-teknisk forskning. Strukturen är allmän, men exemplen är många. Flertalet är hämtade från CERTEC, Centrum för Rehabiliteringsteknik, inom Tekniska Högskolan i Lund, där alla författarna är verksamma: Bodil Jönsson, universitetslektor och forskningsledare, Håkan Eftring, tekn lic och forskarstuderande inom robotteknik, Charlotte Magnusson, tekn dr (fysik) och inriktad mot artificiell intelligens, och Arne Svensk, civ ing, forskarstuderande och tidigare omsorgsarbetare under 20 år.
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| 37. |
- Jönsson, Bodil, et al.
(författare)
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Situated research and design for everyday life
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper elaborates theoretical and methodological aspects of design processes in a disability context and aims to relate them to other sciences. It particularly emphasizes situated aspects of research: the need for being there, with the users in their
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| 38. |
- Jönsson, Bodil, et al.
(författare)
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Situated research and design for everyday life
- 2005
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Ingår i: Proceedings of Nordes, Nordic Design Research.
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Konferensbidrag (refereegranskat)abstract
- This paper presents examples of different aspects of design in a disability context with the aim of revealing some of its fundamentals. It particularly emphasizes situated aspects of research: the need for being there, with the users in their daily lives – where the action is.
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| 39. |
- Kristensson Hallström, Inger, et al.
(författare)
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eHealth as an Aid for Facilitating and Supporting Self-Management in Families with Long-Term Childhood Illness; Development, Evaluation, and Implementation in Clinical Practice
- 2023
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Ingår i: Clinical Health Promotion - Research and Best Practice for patients, staff and community. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Introduction eHealth, defined by WHO as: “the transfer of health resources and healthcare by electronic means” are expected to increase communication between healthcare providers and patients and increase accessibility and patient participation in healthcare. The aim of this research programme is to: 1) develop a sustainable multidisciplinary environment for advancing, evaluating, and implementing models of eHealth to promote self-management for children and their families, and 2) increase the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for supporting self-management in families with long-term childhood illness. Method The research is performed in Sweden, Denmark, and Ethiopia and organized in three research domains: eHealth to enable and promote self-management in advanced paediatric care, eHealth for early diagnosis and treatment in paediatric care, and Co-Creation of multidisciplinary knowledge for the translation of eHealth in practice. The research follows a framework for developing and evaluating complex interventions in healthcare. Through participatory design family members and care providers participate throughout the research process. Quantitative and qualitative data as well as health economics are collected in six clinical areas. Five general areas are run transversal. Results and conclusion Evidence-based best practices in developing and evaluating eHealth in paediatric healthcare will be suggested. As implementation is part of the programme, cost-effective eHealth directly benefiting families and healthcare services will be guaranteed.
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| 40. |
- Krozer, Anatol, et al.
(författare)
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Clean development and demonstration — Sustainable domestic washing - s'wash
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- S´wash är ett idestödsprojekt finansierat av MISTRA, ett finansieringsstöd för att skapa innovativa forskningsprojekt med stor potential att förbättra miljön. S´wash har minskat vattenförbrukningen ned till endast 10,3 liter för en tvätt med tre kilos smutstvätt, en minskning med 79 procent jämfört med standardtvättmaskiner som används i de europeiska hushållen idag. Under projektets gång har ett stort antal tekniker och lösningar utvärderats för att finna lämpliga sätt att implementera dessa i en tvättmaskin. Två stycken prototyper byggdes av Asko och Electrolux för att utvärdera framtagna lösningar och idéer. Prototyperna baserades på standardtvättmaskiner men lösningarna är ännu inte redo för att tas in i produktion.
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| 41. |
- Kumar, TK Sandeep, et al.
(författare)
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Effect of Heating Rates on the Sintering of Oxidized Magnetite Pellets during Induration
- 2015
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Konferensbidrag (refereegranskat)abstract
- Magnetite pellet induration is a combination of complex physicochemical phenomena – oxidation, sintering and theheat transfer associated with them. Depending on the pellet properties and the environment it encounters duringthe induration, the oxidation and sintering course may vary and the mechanisms will interact. To be able to predict their course and control it, the kinetics of these phenomena needs to be understood. One approach is to determine the kinetics of the phenomena in isolation. The present investigation is aimed to predict and studying the sintering behavior of oxidized magnetite (hematite) pellets exposed to different heating rates. Experiments have been carefully performed at three different heating rates to capture the sintering behavior during induration using an optical dilatometer, and also used for validation.
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| 42. |
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| 43. |
- Kytö, Mikko, et al.
(författare)
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Designing bimanual tangible interaction for stroke survivors
- 2018
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Ingår i: TEI 2018 - Proceedings of the 12th International Conference on Tangible, Embedded, and Embodied Interaction. - New York, NY, USA : ACM. - 9781450355681 ; 2018-January, s. 245-252
-
Konferensbidrag (refereegranskat)abstract
- Stroke is a significant cause of long-term disability, impairing over 10 million peoples motor function, primarily on one side of the body every year. Whilst effective rehabilitation exercises can help recover and maintain some affected motor function, stroke survivors often do not carry out enough of these. Instead relying on their `good' side to carry out tasks. However, this leads to poor recovery limiting the ability to carry out everyday bimanual tasks (such as dressing or cooking). We present work that seeks to support stroke survivors to engage in bimanual rehabilitation through interaction with augmented tangible objects that can be used to control everyday devices. Through a user-centered design process, we uncovered how bimanual rehabilitation can be supported. This led to the development of the ActivSticks device that allows bimanual rehabilitation and interaction with other devices and services.
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| 44. |
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| 45. |
- Ling Lundström, Maria, et al.
(författare)
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Faecal biomarkers for diagnosis and prediction of disease course in treatment-naïve patients with IBD.
- 2024
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Ingår i: Alimentary Pharmacology and Therapeutics. - 0269-2813 .- 1365-2036.
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Faecal biomarkers can be used to assess inflammatory bowel disease (IBD).AIM: To explore the performance of some promising biomarkers in diagnosing and predicting disease course in IBD.METHODS: We included 65 patients with treatment-naïve, new-onset Crohn's disease (CD), 90 with ulcerative colitis (UC), 67 symptomatic controls (SC) and 41 healthy controls (HC) in this prospective observational study. We analysed faecal samples for calprotectin (FC), myeloperoxidase (MPO), human neutrophil lipocalin (HNL), eosinophil cationic protein ECP and eosinophil-derived neurotoxin (EDN) and compared markers among groups. We assessed the diagnostic capability of biomarkers with receiver operating characteristic curves. Clinical disease course was determined for each patient with IBD and analysed the association with biomarkers by logistic regression.RESULTS: All markers were elevated at inclusion in patients with IBD compared with HC (p < 0.001) and SC (p < 0.001). FC (AUC 0.85, 95% CI: 0.79-0.89) and MPO (AUC 0.85, 95% CI: 0.80-0.89) showed the highest diagnostic accuracy in distinguishing IBD from SC. The diagnostic ability of biomarkers differed between IBD subtypes with the highest performance for FC and MPO in CD. The diagnostic accuracy was further improved by combining FC and MPO (p = 0.02). Levels of FC, MPO and HNL at inclusion were predictive of an aggressive disease course with MPO showing the strongest association (p = 0.006).CONCLUSIONS: This study provides new insight into the diagnostic and prognostic capability of neutrophil and eosinophil biomarkers in IBD and suggests that MPO, alone or in combination with FC, may add to the diagnostic power of faecal biomarkers.
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| 46. |
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| 47. |
- Luciani, Annie, et al.
(författare)
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Examplary enactive tasks and associated technological bottlenecks
- 2006
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Ingår i: 2nd Enactive Workshop, McGill University, Montreal, Canada.
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Konferensbidrag (refereegranskat)abstract
- States of the art performed in technology of haptic interfaces, action-vision and action - audition cooperation in mediated computerized systems, showed that, despite the huge development and boiling in such domains, we are confronted now to some critical
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| 48. |
- Luciani, Annie, et al.
(författare)
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Perception of Virtual Multi-sensory Objects : Some Musings on the Enactive Approach
- 2008
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Ingår i: Cyberworlds 2008.
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Konferensbidrag (refereegranskat)abstract
- In this paper we explore, by means of three pilot observational studies using virtual objects, how direct perception through action of multi-sensory audiovisual and haptic object properties support the creation of new categories of believable and plausible objects than can be perceived as being different from those that were presented The three experiments are based on variations of “Pebble boxes” and consist in the exploration and the manipulation of multiple moving multi-sensory objects (the Pebbles). Results from observations and informal interviews with participants illustrate how an inferred scene is apparently constructed from experience, as assumed in the cognitive Enactive concept, by means of three complementary strategies: the Emergent Exploratory Procedures, Dynamic Manipulation Adaptation, and Adaptive Experimental Learning. Findings also illustrate the complementarities between the so-called ergotic and semiotic situations with respect to the strategies that were apparently successful in inferring a believable and plausible scene. Several fundamental questions arise which are relevant to the Enactive assumption with respect to the coupling between perceiving and acting, some of which are discussed here.
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| 49. |
- Luciani, Annie, et al.
(författare)
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Perception of virtual multisensory mobile objects
- 2007
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Ingår i: Enactive/07 Proceedings of the 4th International Conference on Enactive Interfaces. - 1958-5497. ; , s. 153-156
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Konferensbidrag (refereegranskat)abstract
- We explore here, through three complementary experiments on virtual objects, how intimate active relations with multisensory audio-visual and haptics perceptions allow to the cognitive creation of new believable and plausible objects that can be different of the virtual ones objectively implemented. The three experiments are based on "Pebble Boxes" and consist in the exploration and the manipulation of multiple moving multisensory objects (the Pebbles). They show how an inferred scene is constructed from experience, as assumed in the cognitive Enactive concept, by means of three complementary strategies: "the Emergent Exploratory Procedures (EEP)", "the Dynamic Manipulation Adaptivity (DMA)" and "the Adaptive Experimental Learning (AEL)". It shows aslo the complementarity between the ergotic and the semiotic situation on the strategies to infer a believable and plausible scene.
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| 50. |
- Magnusson, Ann-Charlotte
(författare)
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Stenmurar på Öland
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Stenmurarna är kanske Ölands mest karaktäristiska agrara monument. Tillsammans binder de många milen stenmurar samman flera århundradens historia. I mer än 2000 år har ölänningarna byggt upp stenmurar till hägnader. Först efter mitten av 1900-talet har kunskapen om konsten att lägga murar börjat avta. Numera läggs nya stenmurar främst omkring bostadstomter och odlingslandskapets gamla stenmurar underhålls företrädesvis när de omgärdar betesmarker. Med de murar som försvunnit har både ett stycke öländsk historia och en del av växt- och djurlivet försvunnit. Somliga murar förfaller så sakteliga och övergår till stensträngar. Stenmurarna, som numera är biotopskyddade, har på senare år varit i fokus genom att de framhållits som odlingshinder för det rationella jordbruket. Denna broschyr har tagits fram för att på ett lättfattligt sätt lyfta fram de öländska stenmurarna, vilka ännu mil efter mil indelar det öländska odlingslandskapet.
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