| 1. |
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| 2. |
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| 3. |
- Andersson, Jan, et al.
(författare)
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Oxygen saturation and cognitive performance.
- 2002
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Ingår i: Psychopharmacology. - : Springer Science and Business Media LLC. - 0033-3158 .- 1432-2072. ; 162:2, s. 119-128
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the experiments was to investigate how inhalation of 100% oxygen affected cognitive performance. A test battery was developed that was designed to capture different aspects of cognitive processes, i.e., perception, attention, working memory, long-term memory and prospective memory. All tests were verbally based, thus reducing cognitive spatial processes to a minimum. In experiment 1, 48 participants volunteered in a complete factorial within-participant design. Two different conditions for type of gas were used, inhalation of 100% oxygen and inhalation of breathing air (approximately 21% oxygen balanced with nitrogen). The inhalation was performed during the 1 min prior to starting each separate test. The instructions for each test were given during the inhalation period. All participants inhaled oxygen or breathing air through a Swedish military pilot mask. Physiological (heartbeats per minute and blood oxygen saturation level) reactions were recorded continuously throughout the session. Participants also completed a mood-state questionnaire before and after the test battery. The results revealed that cognitive performance were not affected by inhalation. Hence, this experiment does not replicate previous findings that suggest that inhalation of 100% oxygen could increase cognitive performance. Another experiment was performed to control for methodological issues. Experiment 2 revealed exactly the same pattern, i.e., inhalation of oxygen did not affect cognitive functioning.
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| 4. |
- Cornelissen, Johannes H C, et al.
(författare)
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Global negative vegetation feedback to climate warming responses of leaf litter decomposition rates in cold biomes
- 2007
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 10:7, s. 619-627
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Tidskriftsartikel (refereegranskat)abstract
- Whether climate change will turn cold biomes from large long-term carbon sinks into sources is hotly debated because of the great potential for ecosystem-mediated feedbacks to global climate. Critical are the direction, magnitude and generality of climate responses of plant litter decomposition. Here, we present the first quantitative analysis of the major climate-change-related drivers of litter decomposition rates in cold northern biomes worldwide.Leaf litters collected from the predominant species in 33 global change manipulation experiments in circum-arctic-alpine ecosystems were incubated simultaneously in two contrasting arctic life zones. We demonstrate that longer-term, large-scale changes to leaf litter decomposition will be driven primarily by both direct warming effects and concomitant shifts in plant growth form composition, with a much smaller role for changes in litter quality within species. Specifically, the ongoing warming-induced expansion of shrubs with recalcitrant leaf litter across cold biomes would constitute a negative feedback to global warming. Depending on the strength of other (previously reported) positive feedbacks of shrub expansion on soil carbon turnover, this may partly counteract direct warming enhancement of litter decomposition.
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| 5. |
- Dahlström, Nicklas, et al.
(författare)
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A Comparison of Two Recorders for Obtaining In-flight Heart Rate Data
- 2006
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Ingår i: Applied Psychophysiology and Biofeedback. - : Springer-Verlag New York. - 1090-0586 .- 1573-3270. ; 31:3, s. 273-279
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Tidskriftsartikel (refereegranskat)abstract
- Measurement of mental workload has been widely used for evaluation of aircraft design, mission analysis and assessment of pilot performance during flight operations. Heart rate is the psychophysiological measure that has been most frequently used for this purpose. The risk of interference with flight safety and pilot performance, as well as the generally constrained access to flights, make it difficult for researchers to collect in-flight heart rate data. Thus, this study was carried out to investigate whether small, non-intrusive sports recorders can be used for in-flight data collection for research purposes. Data was collected from real and simulated flights with student pilots using the Polar Team System sports recorder and the Vitaport II, a clinical and research recording device. Comparison of the data shows that in-flight heart rate data from the smaller and less intrusive sports recorder have a correlation of.981 with that from the clinical recorder, thus indicating that the sports recorder is reliable and cost-effective for obtaining heart rate data for many research situations.
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| 6. |
- Dahlström, Nicklas, et al.
(författare)
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Mental Workload in Aircraft and Simulator during Basic Civil Aviation Training
- 2009
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Ingår i: The International journal of aviation psychology. - : Taylor & Francis. - 1050-8414 .- 1532-7108. ; 19:4, s. 309-325
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This study investigated mental workload in basic civil aviation training. Heart rate, eye movement and subjective ratings from eleven students were collected during simulator and aircraft sessions. Results show high correspondence in psychophysiological reactions between the sessions. For some flight segments heart rate was consistently lower in the simulator, suggesting higher mental workload in the aircraft. Differences in heart rate during rejected take-off and engine failure indicate that the increase of workload starts in advance of an “unexpected“ event in the simulator and seem to be of preparatory nature, while more connected to management of the situation in the aircraft. Descriptors: psychophysiology, mental workload, aviation training, flight simulation, learning transfer
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| 7. |
- Dahlström, Nicklas, et al.
(författare)
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Recording of Psychophysiological Data during Aerobatic Training
- 2011
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Ingår i: The International journal of aviation psychology. - : Taylor & Francis. - 1050-8414 .- 1532-7108. ; 21:2, s. 105-122
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Tidskriftsartikel (refereegranskat)abstract
- Measuring pilot mental workload can be important for understanding cognitive demands during flight involving unusual movements and attitudes. Heart rate, eye movements, EEG and subjective ratings from seven flight instructors was collected for a flight including a repeated aerobatics sequence. Heart rate data and subjective ratings showed that aerobatic sequences produced the highest levels of mental workload and that heart rate can identify low-G flight segments with high mental workload. Blink rate and eye movement data did not support previous research regarding their relation to mental workload. EEG data was difficult to analyze due to muscle artifacts.
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| 8. |
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| 9. |
- Gustavsson Christiernin, Linn, 1979-, et al.
(författare)
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Easylayer : MLD in an application portal with multiple user groups
- 2007
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Ingår i: Proceedings of the Iadis International Conference Applied Computing 2007. - : IADIS. - 9789728924300 ; , s. 27-34
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In large organizations there are usually rather large groups of heterogeneous users with different tasks and different needs. Their requirements would most likely vary a lot when the system is designed to grant them access to different parts of the functions and applications In our earlier work we have tested the interface concept of Multi-Layered Design (MLD) on an operating system where each layer had a set of applications and tools. The users working with the system could get access to different applications depending on their level of experience or their different needs. The current paper presents how the MLD concept is taken one step further; implementing a layered design in a multi-user portal on a Citrix server. When a network solution is used, new available possibilities are given. The MLD approach can be combined with a role based access technique can the layered structure can be used in different ways for many different groups of users. In the study a MLD mushroom structure is employed where the user category decides the set of layers the different user groups can choose from while the individual user’s tasks and experience guide the choice of the specific layer. Thin clients are used to access the layer structure and five personas are made to represent the potential user groups. The results show that MLD can be used within a Citrix environment and that it is a viable alternative or complement for multi-user portals
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| 10. |
- Hellsmark, Hans, 1974, et al.
(författare)
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Teknologiska innovationssystem inom energiområdet: En praktisk vägledning till identifiering av systemsvagheter som motiverar särskilda politiska åtaganden
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att illustrera hur ett praktiskt inriktat ramverk, tekno- logiska innovationssystem (TIS), kan användas av analytiker och beslutsfattare vid departement och myndigheter för att analysera strategiskt viktiga teknikområden ?????????????????????????????????????????????????????????????????????????????I rapporten analyseras fem TIS centrerade kring havsbaserad vindkraft, marin energi, ????????????????????????????????????????????????????????????????????????????????????? systemsvagheter som bromsar områdets vidare utveckling, vilka som kan åtgärdas av systemets aktörer och vilka som motiverar särskilda politiska åtaganden. Rapporten utgör därmed ett underlag för att formulera åtgärder för att åstadkomma ökad innova- tion, teknikspridning och industrialisering inom ovan nämnda teknikområden.Studien har även möjliggjort en jämförande analys av likheter och skillnader ???????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????????? mellan områdena – de är starka respektive svaga av olika orsaker. Detta visar att ???????????????????????????????????????????????????????????????????????Samtidigt har områdena gemensamma drag. Systemets aktörer, där även politiska ???????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????- skapsnätverk. Men de har varit sämre på att skapa tidiga nischmarknader som ger utrymme för fortsatt lärande och kostnadsreduktion. Sådana nischer kan ibland skapas av marknadens aktörer, men ofta krävs politiska styrmedel. De behövs för att investeringar i kunskapsutveckling ska kunna nyttiggöras och för att en bred industriell utveckling inom nya områden skall göras möjlig i Sverige.Vidare presenteras lärdomar kring vad en aktiv teknikpolitik innebär. Två huvud- ??????????????????????????????????????????????????????????????????????????????- hällsbygget och därför bör vara ett politikområde bland många samt att den skarpa ??????????????????????????????????????????????????????????????????????????????- ?????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????? olika faser av innovationssystemets utveckling.För att lyckas med en aktiv teknikpolitik behövs en hög grad av koordinering ??????????????????????????????????????????????????????????????????????? teknikområden så att ”rätt” typ av åtgärder kan sättas in vid ”rätt” tidpunkt av ”rätt” aktör. TIS-ramverket lyfts här fram som en metod för att skapa ett sådant underlag. Slutligen presenteras en metod för projektbedömningar som syftar till att stötta handläggare i utvärderingar av projekt inom nya teknikområden.Rapporten i sin helhet riktar sig särskilt till beslutsfattare och handläggare vid myndigheter, departement och politiker, men även andra organisationer och indi- vider med intresse av att högt ställda klimatmål ska kunna nås samtidigt som en positiv näringslivsutveckling möjliggörs.
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| 11. |
- Innala, Lena, et al.
(författare)
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Age at onset determines severity and choice of treatment in early rheumatoid arthritis : a prospective study
- 2014
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Ingår i: Arthritis Research & Therapy. - : BioMed Central. - 1478-6362 .- 1478-6354. ; 16:2, s. R94-
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Disease activity, severity and co-morbidity contribute to increased mortality in patients with rheumatoid arthritis (RA). We evaluated the impact of age at disease onset on prognostic risk factors and treatment in early disease.METHODS: In this study, 950 RA patients were followed regularly from inclusion (<12 months from symptom onset) for disease activity (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tender/swollen joints, visual analogue scale (VAS) pain/global, disease activity score (DAS28)) and function (health assessment questionnaire (HAQ)). Disease severity, measured by radiographs of hands/feet (erosions, Larsen score), extra-articular disease, nodules and co-morbidities and treatment (disease-modifying anti-rheumatic drugs (DMARDs), corticosteroids, biologics, nonsteroidal anti-inflammatory drugs (NSAIDs)) were recorded at inclusion and after 5 years. Autoantibodies (rheumatoid factor (RF), anti-nuclear antibodies (ANA), antibodies against cyclic citrullinated peptides (ACPA)) and genetic markers (human leukocyte antibody (HLA)-shared epitope, protein tyrosine phosphatase nonreceptor type 22 (PTPN22)) were analyzed at inclusion. Data were stratified as young (YORA) and late (LORA) onset RA, defined as being below/above median age (58 years) at onset.RESULTS: LORA was associated with lower frequency of ACPA (P <0.05) and carriage of PTPN22-T variant (P <0.01), but with greater disease activity at inclusion measured as ESR (P < 0.001), CRP (P <0.01) and accumulated disease activity (area under the curve for DAS28) at 6 (P <0.01), 12 (P <0.01) and 24 months (P <0.05), and a higher HAQ score (P <0.01) compared with YORA. At baseline and 24 months, LORA was more often associated with erosions (P <0.01 for both) and a higher Larsen score (P <0.001 for both). LORA was more often treated with corticosteroids (P <0.01), less often with methotrexate (P <0.001) and biologics (P <0.001). YORA was more often associated with early DMARD treatment (P <0.001). Multiple regression analyses supported our findings regarding impact of age on chosen treatment.CONCLUSION: YORA patients were more frequently ACPA-positive. LORA was more often associated with erosions, higher Larsen scores, disease activity and HAQ at baseline. Nevertheless, YORA was treated earlier with DMARDs, whilst LORA was more often treated with corticosteroids and with less DMARDs in early disease. This could have implications for development of co-morbidities.
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| 12. |
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| 13. |
- Innala, Lena, et al.
(författare)
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Cardiovascular events in early rheumatoid arthritis (RA) are a result of inflammatory burden and traditional risk factors : a five year prospective study
- 2011
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Ingår i: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6362 .- 1478-6354. ; 13:4, s. R131-
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Co-morbidity and mortality due to cardiovascular disease (CVD) are increased in patients with rheumatoid arthritis (RA). Most published studies in this field are retrospective or cross sectional. We investigated the presence of traditional and disease related risk factors for CVD at the onset of RA and during the first 5 years following diagnosis. We also evaluated their potential for predicting a new cardiovascular event (CVE) during the 5 year follow-up period and the modulatory effect of pharmacological treatment.Methods All patients from the four northern-most counties of Sweden with early RA are since December 1995 consecutively recruited at diagnsosis (T0) into a large survey on the progress of the disease. Information regarding cardiovascular co-morbidity and related predictors was collected from clinical records and supplemented with questionnaires. By April 2008, 700 patients had been included of whom 442 patients had reached the 5-year follow-up (T5).Result Among the 442 patients who reached T5 during the follow-up period, treatment for hypertension increased from 24.5 to 37.4% ( p<0.001)), diagnosis of diabetes mellitus (DM) from 7.1 to 9.5%(p<0.01) whilst smoking decreased from 29.8 to 22.4 % ( p<0.001) and the BMI from 26.3 to 25.8( p<0.05) , respectively. By T5, 48 patients had suffered a new CVE of which 12 were fatal. A total of 23 patients died during the follow-up period. Age at disease onset, male sex, a previous CVE, DM, treatment for hypertension, triglyceride level, cumulative disease activity (AUC DAS28), extra-articular disease, corticosteroid use, shorter duration of treatment with DMARDs and use of COX-2 inhibitors increased the hazard rate for a new CVE. A raised ESR at inclusion and AUC DAS28 at 6 months increased the hazard rate of CVE independently whilst DMARD treatment was protective in multiple Cox extended models adjusted for sex and CV risk factors. The risk of a CVE due to inflammation was potentiated by traditional CV risk factors.Conclusion The occurrence of new CV events in very early RA was explained by traditional CV risk factors and was potentiated by high disease activity. Treatment with DMARDs decreased the risk. The results may have implications for cardio-protective strategies in RA.
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| 14. |
- Innala, Lena, 1060-, et al.
(författare)
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Co-morbidity in patients with early rheumatoid arthritis - inflammation matters
- 2016
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Ingår i: Arthritis Research & Therapy. - : BioMed Central. - 1478-6362. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- Background: Patients with rheumatoid arthritis (RA) suffer from co-morbidities that contribute to a shortened lifespan. Inflammation is important for the development of cardiovascular disease, but little is known on its relationship with other co-morbidities. We investigated the role of inflammation for the development of new comorbidities in early RA. Methods: Since 1995, all patients with early RA in Northern Sweden are included in a prospective study on comorbidities, with a total of 950 patients being included. At the time for this study, 726 had been ill for >= 5 years. Data on co-morbidities, clinical and laboratory disease activity and pharmacological therapy were collected from patient records and further validated using a questionnaire at RA onset (T0) and after 5 years (T5). Results: Of the patients, 53.2 % of the patients had one or more co-morbidity at onset, the commonest being: hypertension (27.3 %), obstructive pulmonary disease (13.9 %), diabetes (8.0 %), hypothyroidism (6.3 %) and malignancy (5.0 %). After 5 years, 41.0 % had developed at least one new co-morbidity, the most common being: hypertension (15.1 %), malignancy (7.6 %), stroke/transient ischemic accident (5.1 %), myocardial infarction (4.3 %) and osteoporosis (3.7 %). Age at disease onset, a raised erythrocyte sedimentation rate (ESR) at inclusion, previous treatment with glucocorticoids (GC; p < 0.001 for all), extra-articular RA (Ex-RA; p < 0.01), DAS28 (area under the curve) at 24 months (p < 0.05), previous smoking at inclusion (p = 0.058) and male gender (p < 0.01) were associated with a new co-morbidity overall at T5. Treatment with biologics (p < 0.05) reduced the risk. In multiple logistic regression modelling, ESR (p = 0.036) at inclusion was associated with a new co-morbidity after 5 years, adjusted for age, sex, smoking and GC treatment. In a similar model, Ex-RA (p < 0.05) was associated with a new co-morbidity at T5. In a third model, adjusted for age and sex, a new pulmonary co-morbidity was associated with a smoking history at inclusion (p < 0.01), but not with ESR. Conclusion: There was substantial co-morbidity among early RA patients already at disease onset, with considerable new co-morbidity being added during the first five years. Measures of disease activity were associated with the occurrence of a new co-morbidity indicating that the inflammation is of importance in this context.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Lyberg-Åhlander, Viveka, et al.
(författare)
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Prevalence of Voice Disorders in the General Population, Based on the Stockholm Public Health Cohort
- 2019
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Ingår i: Journal of Voice. - : Elsevier BV. - 0892-1997. ; 33:6, s. 900-905
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate the prevalence of voice disorders in the general population. Study design: Analysis of data from the Stockholm Public Health Cohort. Methods: A public health survey was distributed to an open cohort of 114,538 adults >18 years of age in the area of Stockholm County, Sweden. The survey included one question about voice problems, estimating the extent of occurrence of voice problems, excluding voice problems during colds/upper airway infections. The question was tested for validity and reliability in n = 166 voice healthy individuals and n = 183 patients with benign voice lesions. The construct validity was tested against two established self-assessment questionnaires. The question was established to correspond to tiring, strain, and hoarseness. Prevalence of voice problems and correlations with age, gender, occupation, hearing, smoking, and socio-economic status were calculated. Results: The overall prevalence of voice disorders in the entire group was estimated to 16.9%, where 15.5% voice problems were rated to occur to a small extent and 1.4% to a great extent. Women were significantly more prone to report voice problems than men. The highest ratings of a great extent of voice problems were found in both women and men >85 years of age. As for occupation, the highest prevalence of voice problems was found in teaching and service occupations. Conclusions: The prevalence of voice problems was estimated to 16.9% in the entire group. Women reported significantly more voice problems than men and voice problems were significantly more common in ages >65. This study of self-reported voice problems in a general population is one of the largest of its kind.
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| 19. |
- Magnusson, J., et al.
(författare)
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Cumulative incidence of ureteroenteric strictures after radical cystectomy in a population-based Swedish cohort
- 2021
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Ingår i: Scandinavian Journal of Urology. - : Medical Journals Sweden AB. - 2168-1805 .- 2168-1813. ; 55:5, s. 361-365
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Tidskriftsartikel (refereegranskat)abstract
- Objective The incidence of benign ureteroenteric strictures following radical cystectomy (RC) for urinary bladder cancer (UBC) is investigated mainly in single-centre studies from high-volume centres. The aim of this study was to evaluate the cumulative incidence of strictures and risk factors in a population-based cohort. Patients and methods Data was collected from Bladder Cancer Data Base Sweden (BladderBaSe). The primary endpoint was stricture with intervention. Secondary endpoint included hydronephrosis both with/without intervention. Results In total, 5,816 patients were registered as having had RC due to UBC between 1997 and 2014. After a median follow-up of 23.5 months (IQR = 9.0-63.1 months; range = 0.0-214.0 months), we found that 515 (8.9%) patients underwent intervention for stricture. Seven hundred and sixty-one (13.1%) patients were diagnosed with hydronephrosis without intervention. The cumulative incidence of strictures with intervention was 19.7% (95% CI = 16.7-23.1%) during the 17 years of follow-up. In the first year, the cumulative incidence of strictures was 5.6% (95% CI = 5.0-6.2%), and in the first 2 years 8.4% (95% CI = 7.6-9.3%). For the secondary endpoint, the cumulative incidence was 30.4% (95% CI = 26.7-33.1%) after 17 years. Only the year of RC was associated with stricture incidence in Cox regression analysis, whereas hospital cystectomy volume, patient age and patient sex were not. Conclusion Ureteroenteric strictures requiring intervention may be more common than previously reported, affecting nearly one fifth of patients who have undergone RC for UBC. The annual incidence was highest in the first 2 years after surgery but the cumulative incidence increased continuously during 17 years of follow-up.
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| 20. |
- Magnusson, Jesper, 1984-
(författare)
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On the design of hybrid DC-breakers consisting of a mechanical switch and semiconductor devices
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The interest of using direct current in networks for both transmission and distribution of power is increasing due to the higher efficiency compared to the alternating current used today. As no natural zero crossings exist in direct current, the interruption of fault currents becomes a challenge. Several circuit breaker topologies have been proposed to fulfill the requirements for DC grids. One such topology is the hybrid DC-breaker consisting of three parallel branches: a mechanical switch, a semiconductor branch, and a metal oxide varistor.The current interruption in the hybrid DC-breaker is made in three steps. A mechanical switch carries the nominal current with low losses during normal operation. When the breaker is tripped to interrupt the current, the mechanical switch is opened and commutates the current into the semiconductor branch. This branch will then conduct the current as the mechanical switch regains its voltage withstand. The semiconductors turn off and force the current into the varistor branch where the magnetic energy is absorbed and the current is forced to zero.This thesis is based on simulations and experiments to obtain design rules for such a DC-breaker. It has been shown that several aspects needs to be considered. Simulations are performed with several different models to obtain the requirements of each of the components in the DC-breaker.First of all, the choice of the semiconductor is important. There are a number of components available in the market, but typically they are optimized for fast switching applications like inverters rather than circuit breaker applications that only requires one single switching. Due to the high current and voltage ratings and the easy control, the IGBT seems to be the best choice among the commercially available components.Simulations on the mechanical switch show that there is an optimal combination of opening time and arc voltage of the to obtain a successful commutation into the semiconductor branch. The actuator is a key component since a relatively low increase in performance of the actuator drive circuit, significantly decreases the requirement of the other components in the DC-breaker.A significant part of the work has been put on the voltage transient during the turn-off of the semiconductor. As the current is forced into the varistor branch, the stray inductance in that loop will result in an over-voltage due to the high current derivative. A new type of snubber has been investigated using another varistor mounted close to the semiconductor. It has been shown that the function of the varistor snubber can be divided into two regions depending on the ratio between the snubber and the main varistor. If the ratio is high enough, the energy absorbed in the snubber varistor is only a few percent of the total energy.
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| 21. |
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| 22. |
- Magnusson Nählinder, Staffan, 1971-, et al.
(författare)
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Dynamic Assessment of Pilot Mental Status
- 2002
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Ingår i: Proceedings of the Human Factors and Ergonomics Society 46th Annual Meeting, Baltimore, MD, USA.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of the present study has been to measure mental workload, situational awareness and performance during specific air-to-ground missions in both simulated and real flight in order to assess operator status. Specifically to compare simulated versus real flight regarding the concepts, to analyze the relationships between physiological reactions, situational awareness, and experienced mental workload and also develop and test causal models of operator function. A second purpose of the study was to develop practically useful methods for analyzing mental workload and performance during operative conditions.
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| 23. |
- Magnusson Nählinder, Staffan, 1971-
(författare)
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Flight Simulator Training : Assessing the Potential
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Mental workload is an important concept and has been proven to be a precursor to situation awareness and operative performance. This thesis describes methods to measure mental workload through self-ratings and psychophysiological measurements. Similarities and differences in psychophysiological reactions and rated mental workload between simulated and real flights are described. The consequences of such similarities and differences are discussed and its possible effect on training potential.A number of empirical studies are presented. They describe the experience and the psychophysiological reactions of pilots flying in a simulator and in real flight. In most cases, the reactions are similar – there is a high degree of accordance in rated mental workload and psychophysiological reaction between simulated and real flight. The studies show, that even though the responses are similar, there are also interesting differences. In one study, the pilots have consistently lower heart rate, higher heart rate variability and less eye movements in the simulator than in real flight. In another study, during certain events, the pilots have higher heart rate in the simulator than in real flight. The results are important in order to understand the training potential of simulators from a human factors perspective. Further, two measurement equipments for psychophysiological recording are compared and various psychophysiological measures are tested in applied settings.The thesis also discusses some methodological aspects, such as methods to create reliable and valid variables in dynamic applied research and how to deal with individual differences. An algorithm is suggested to remove differences between individuals. This facilitates the finding of within-participant effects.Finally, results from a study on embedded training tools are presented. In this study, student pilots and instructors rated the usefulness of several embedded training tools. These tools were built into a simulator to facilitate learning and teaching by illustrating concepts that can be difficult to understand. The results show clearly that such training tools are appreciated by both students and instructors. Well implemented, thoroughly selected training tools can dramatically improve the training potential of future training simulators.
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| 24. |
- Magnusson Nählinder, Staffan, 1971-, et al.
(författare)
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Increasing Training Efficiency Using Embedded Pedagogical Tools in a Combat Flight Simulator
- 2005
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Ingår i: Proceedings of the Human Factors and Ergonomics Society 49th Annual Metting, Orlando, FL, USA.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Many flight simulators today are made to provide a realistic environment for training. However, they often lack the possibility of providing pedagogical feedback to the person in training as well as feedback to any instructor leading the training. The purpose of this paper was to evaluate the usefulness of several pedagogical tools embedded in a flight simulator and to examine their potential for increasing training efficiency. Twenty students and instructors from the Swedish Air Force Flying Training School volunteered in this study. Seven embedded pedagogical tools were assessed using questionnaires. There was a quite consistent opinion in favor of the pedagogical tools implying that the embedded pedagogical tools is the way forward in training simulator development. The results from the present study are believed to be equally valid in many other areas besides flight simulators.
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| 25. |
- Magnusson Nählinder, Staffan, 1971-
(författare)
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Similarities and differences in psychophysiological reactions between simulated and real air-to-ground missions
- 2002
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Ingår i: The International journal of aviation psychology. - : Taylor & Francis. - 1050-8414 .- 1532-7108. ; 12:1, s. 49-61
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the similarities and differences in psychophysiological reactions in simulated and real flight. Five fighter pilots from the Swedish Air Force participated in the study, flying the same type of mission in a simulator and in real flight. Each pilot flew the same mission 3 times in the simulator and later 3 times in real flight. The pilots' heart rate, heart rate variability, and eye movements were continuously measured. Analyses of these data indicate that the pilots' psychophysiological reactions are very analogous in the simulator and in real flight.
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| 26. |
- Magnusson Petzell, Erik, 1977-, et al.
(författare)
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Deviant word order in Swedish poetry
- 2014
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Ingår i: Lingua. - : Elsevier BV. - 0024-3841 .- 1872-6135. ; 143, s. 203-223
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Tidskriftsartikel (refereegranskat)abstract
- It is generally assumed that recurrent deviations from ordinary language in poetry have a non-complex relationship to ordinary grammar. This assumption has been formulated by Fabb (2010) as the Development Hypothesis (DH). In this paper, DH is elaborated within a generative framework and tested upon deviant word order in a sample of 19th century Swedish poetry. The result is that the hypothesis is fairly well corroborated, although not totally. In closing, an alternative hypothesis by Thoms (2010), the Non-Uniformity Hypothesis, is tested. It claims that poetry has more of its own syntax. This hypothesis is shown to yield, on the whole, predictions just as good as OH. Neither of the hypotheses, however, lasts the entire course.
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| 27. |
- Nilsson, Staffan, et al.
(författare)
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Mossfloran på Pepparholm 2016
- 2017
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Ingår i: Botaniska Notiser: utgivna av Lunds botaniska förening (2001-). - 1650-3767. ; 150:1, s. 1-9
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 28. |
- Nordén, Rickard, 1977, et al.
(författare)
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Quantification of torque teno virus and Epstein-Barr virus is of limited value for predicting the net state of immunosuppression after lung transplantation
- 2018
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Ingår i: Open Forum Infectious Diseases. - : Oxford University Press (OUP). - 2328-8957. ; 5:4
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Tidskriftsartikel (refereegranskat)abstract
- Background. Major hurdles for survival after lung transplantation are rejections and infectious complications. Adequate methods for monitoring immune suppression status are lacking. Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. Methods. This prospective single-center study included 98 patients followed for 2 years after transplantation. Bacterial infections, fungal infections, viral respiratory infections (VRTI), cytomegalovirus (CMV) viremia, and acute rejections, as well as TTV and EBV levels, were monitored. Results. The levels of torque teno virus DNA increased rapidly after transplantation, likely due to immunosuppressive treatment. A modest increase in levels of Epstein-Barr virus DNA was also observed after transplantation. There were no associations between either TTV or EBV and infectious events or acute rejection, respectively, during follow-up. When Tacrolimus was the main immunosuppressive treatment, TTV DNA levels were significantly elevated 6-24 months after transplantation as compared with Cyclosporine treatment. Conclusions. Although replication of TTV, but not EBV, appears to reflect the functionality of the immune system, depending on the type of immunosuppressive treatment, quantification of TTV or EBV as biomarkers has limited potential for defining the net state of immune suppression.
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| 29. |
- Patlaka, Christina, et al.
(författare)
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Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels
- 2020
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Ingår i: Eating and Weight Disorders. - : SPRINGER. - 1124-4909 .- 1590-1262. ; 25:5, s. 1387-1397
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Tidskriftsartikel (refereegranskat)abstract
- Aim Tartrate-resistant acid phosphatase (TRAP) exists as isoforms 5a and 5b. TRAP 5a is a biomarker of chronic inflammation and influences adipose tissue and 5b associates with bone metabolism/pathologies. The aim was to investigate the association of serum TRAP 5a/5b isoforms with fat and bone markers and anthropometric parameters in patients with anorexia nervosa (AN) during weight gain therapy. Methods Twenty-five Swedish female AN patients, age 16-24 years, were treated for 12 weeks with a high-energy diet with six meals daily. Serum TRAP 5a/5b, markers of fat/glucose metabolism, markers of bone resorption and formation were measured. Parameters of bone and body composition were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Results BMI increased from median 15.4 kg/m(2)to 19.0 kg/m(2),p < 0.0001. TRAP 5a and 5a/5b ratio increased but TRAP 5b decreased during the study. TRAP Delta 5a and Delta 5b correlated with Delta insulin and Delta adiponectin, respectively. TRAP 5b correlated with trabecular density at start but not at week 12. At 12 weeks, TRAP 5b correlated with CTX, and Delta decrease in TRAP 5b correlated to Delta increase in bone-specific alkaline phosphatase. Conclusions This clinical interventional study resulted in increased BMI in patients with AN. The decreased TRAP 5b protein levels confirm a role for TRAP 5b as a marker of bone resorption, whereas increased TRAP 5a seemed to derive from systemic changes in bone as well as metabolic changes. The combined detection of TRAP 5a and TRAP 5b in serum could be an indicator of improved bone metabolism.
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| 30. |
- Peterson, Christer, et al.
(författare)
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Detection of Local Mast-Cell Activity in Patients With Food Hypersensitivity
- 2007
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Ingår i: Journal of investigational allergology & clinical immunology. - 1018-9068 .- 1698-0808. ; 17:5, s. 314-320
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Tidskriftsartikel (refereegranskat)abstract
- Background: Mast cells play a central role in many inflammatory diseases and assessment of their activation may be of use to provide objective confirmation of the outcome of food challenge in the diagnosis of food hypersensitivity. However, to date, assessment of mastcell activation using serum markers has been unsuccessful. Objective: The aim of this study was to explore whether locally released tryptase could be detected in stool samples from patients with food hypersensitivity. Methods: Nine patients (median age, 55 years; range, 26 - 68 years) with food hypersensitivity confirmed by double-blind placebo-controlled food challenge were included in the study. Tryptase concentration was assessed in stool samples collected before and after an open food challenge at home and symptoms were recorded throughout the study. Tryptase concentration was also assessed in stool samples from 16 apparently healthy individuals (median age, 44 years; range, 27 - 72 years). Results: Measurement of fecal tryptase levels in 16 healthy control subjects revealed an upper limit of the normal range (mean + 2 SD of log transformed data) of 10 ng/g. Fecal tryptase levels exceeded 10 ng/g in 7 out of 9 patients in one or more samples obtained during the study. The tryptase levels varied between patients in response to the food challenge and the individual mean levels of tryptase correlated with the corresponding levels of the inflammatory marker eosinophil protein X (ρ = 0.7500, P = .02). Conclusion: Measurement of tryptase levels in stool samples is feasible using the method described here. Our results revealed elevated concentrations of fecal tryptase in patients with food hypersensitivity. However, several factors, including food exposure, may account for the increase in fecal tryptase and further studies are necessary to elucidate the role of mast cells in food hypersensitivity.
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| 31. |
- Riman, Tomas, et al.
(författare)
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Hormone replacement therapy and the risk of invasive epithelial ovarian cancer in Swedish women
- 2002
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 94:7, s. 497-504
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Estrogen replacement therapy (ERT), which is mainly used to relieve climacteric symptoms, increases a woman's risk for uterine endometrial cancer and epithelial ovarian cancer (EOC). Estrogens are often combined with progestins in hormone replacement therapy (HRT) to reduce the risk of uterine endometrial cancer. Data on the association between HRT including progestins and EOC risk are limited. This nationwide case-control study examined EOC risk in relation to HRT regimens with sequentially added progestins (HRTsp) and continuously added progestins (HRTcp). METHODS: Between 1993 and 1995, we enrolled 655 histologically verified incident case patients with EOC and 3899 randomly selected population controls, all 50-74 years of age. Data on HRT use were collected through mailed questionnaires. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by the use of unconditional logistic regression. RESULTS: Risks of EOC were elevated among ever users as compared with never users of both ERT (OR = 1.43, 95% CI = 1.02 to 2.00) and HRTsp (OR = 1.54, 95% CI = 1.15 to 2.05); risks were elevated for serous, mucinous, and endometrioid subtypes. For all EOC types combined, the greatest risk increases were seen with hormone use exceeding 10 years. Ever use of HRTcp was not associated with increased EOC risk relative to HRTcp never use (OR = 1.02, 95% CI = 0.73 to 1.43). The risk of EOC was elevated among HRTsp ever users as compared with HRTcp ever users (OR = 1.78, 95% CI = 1.05 to 3.01). ORs for EOC after ever use of low-potency estrogens were 1.18 (95% CI = 0.89 to 1.55) for oral and 1.33 (95% CI = 1.03 to 1.72) for vaginal applications, but no relationship was seen between EOC risk and duration of use. CONCLUSION: Ever users of ERT and HRTsp but not HRTcp may be at increased risk of EOC.
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| 32. |
- Sunesson, Sune, et al.
(författare)
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The Flight from Universalism.
- 1998
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Ingår i: European Journal of Social Work. - 1369-1457. ; 1
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Tidskriftsartikel (refereegranskat)
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| 33. |
- Tubić, Bojan, 1984, et al.
(författare)
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Different osteocalcin forms, markers of metabolic syndrome and anthropometric measures in children within the IDEFICS cohort
- 2016
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Ingår i: Bone. - : ELSEVIER SCIENCE INC. - 8756-3282 .- 1873-2763. ; 84, s. 230-236
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Osteocalcin (OC), an aboundant non-collagenous bone protein, is inversely associated with parameters of glucose metabolism. Interactions between bone tissue and energy metabolism have not been thoroughly investigated during childhood. This study investigated OC, metabolic parameters and anthropometric characteristics in normal weight and overweight/obese children. Methods: This study comprised 108 (46 normal weight/62 overweight/obese) Swedish 2-9 year old children. Anthropometric data, insulin, glucose, glycosylated haemoglobin (HbA1c), HOMA index, vitamin D, adiponectin, total OC, carboxylated OC (cOC) and undercarboxylated OC (ucOC) were analysed. Results: No difference was found for total OC between the normal and overweight/obese groups, with a mean (+/- SD) value of 82.6 ( +/- 2.8) ng/mL and 77.0 ( +/- 2.4) ng/mL, (P = 0.11), respectively. Overweight children had lower cOC levels, mean 69.1 ( +/- 2.2) ng/mL, vs. normal weight children, mean 75.6 ( +/- 2.5) ng/mL (P = 0.03). The mean ucOC levels of 7.9 ( +/- 0.4) ng/mL in overweight children did not differ vs. normal weight children, mean level 7.0 (+/- 0.4) ng/mL, (P = 0.067). None of the three OC forms correlated with any of the measured parameters. Conclusions: The cOC levels were lower in overweight children. There was no correlation between the three OC forms and any of the measured anthropometric or metabolic parameters. OC has been suggested to have a possible metabolic role, but in general the current study in prepubertal children does not support the hypothesis of an association between OC and a positive metabolic profile. (C) 2016 Elsevier Inc. All rights reserved.
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| 34. |
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| 35. |
- Tubić, Bojan, 1984, et al.
(författare)
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Randomised study of children with obesity showed that whole body vibration reduced sclerostin
- 2019
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Ingår i: Acta Paediatrica. - : WILEY. - 0803-5253 .- 1651-2227. ; 108:3, s. 502-513
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Tidskriftsartikel (refereegranskat)abstract
- Aim New strategies are required to increase physical activity and improve metabolic profiles in children with obesity. We studied the effect of whole body vibration (WBV) on children with obesity on biochemical markers of energy and bone metabolism, anthropometric measurements, muscle parameters and calcaneal bone mineral density (BMD). Methods This was a randomised, prospective, controlled study of 30 children with a median age of 13 years (range 7-17) at Queen Silvia Children s Hospital, Gothenburg, Sweden, from 2013 to 2015. The target for the intervention group was to perform WBV three times a week for 12 weeks, and the study parameters were assessed at baseline and 12 weeks. Results The 16 in the WBV group achieved 51% of the planned activity, mainly at home, and were compared with 14 controls. Sclerostin, bone-specific alkaline phosphatase and carboxy-terminal collagen cross-links decreased in the WBV group (p amp;lt; 0.05) and balance improved (p amp;lt; 0.006), but osteocalcin and insulin remained unchanged. Anthropometric data, muscle strength and calcaneal BMD did not differ between the groups. Conclusion WBV did not affect most of the clinical parameters in children with obesity, but the reduction in sclerostin implies that it had direct effects on osteocytes, which are key players in bone mechanotransduction.
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| 36. |
- Tubić, Bojan, 1984, et al.
(författare)
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Relation between bone mineral density, biological markers and anthropometric measures in 4-year-old children: a pilot study within the IDEFICS study.
- 2011
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Ingår i: International journal of obesity (2005). - : Springer Science and Business Media LLC. - 1476-5497 .- 0307-0565. ; 35 Suppl 1
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate the relationship between bone mineral density (BMD), anthropometric characteristics, levels of biological markers for growth, bone turnover, insulin resistance and fat mass in 4-year-old Swedish children. METHODS: Descriptive study with 41 children (28 boys) who had anthropometric measurements and blood samples taken and heel dual-energy X-ray absorptiometry and laser (DXL) performed. The study participants were divided into groups of normal-weight (n=28) and overweight or obese (n=13) children. RESULTS: There was a significant difference in bone mineral content (BMC), BMD and bone mineral apparent density (BMAD) between overweight and normal-weight children. There was a significant positive correlation between BMC, BMD, BMAD and body mass index standard deviation scores (r=0.36, 0.34 and 0.29, P<0.01, respectively), waist circumference (r=0.32, 0.30, P<0.01 and r=0.26, P<0.05, respectively) and subscapular skinfold (r=0.26, 0.25 and 0.23, P<0.05, respectively). BMC and BMD correlated significantly with the sum of skinfold measures (r=0.25 and 0.23, P<0.05, respectively). Adiponectin was significantly inversely correlated with BMC, BMD and BMAD (r=-0.41, -0.40 and -0.41, P<0.01, respectively). Adiponectin was not correlated with skinfold measures. Multiple regression analysis revealed that adiponectin was an independent determinant of BMD, BMC and BMAD. CONCLUSION: To our knowledge, this is the first study investigating BMD assessed by heel-DXL in relation to anthropometry and metabolic markers in 4-year-old children. Adiponectin was significantly inversely correlated with bone mass parameters. Adiponectin may have an independent role in bone development and metabolism in young children.
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| 37. |
- Wahlin, Bengt, et al.
(författare)
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Performance of the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis Is Not Superior to the ACC/AHA Risk Calculator
- 2019
-
Ingår i: Journal of Rheumatology. - : Journal of Rheumatology. - 0315-162X .- 1499-2752. ; , s. 130-137
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Cardiovascular (CV) risk estimation calculators for the general population do not perform well in patients with rheumatoid arthritis (RA). An RA-specific risk calculator has been developed, but did not perform better than a risk calculator for the general population when validated in a heterogeneous multinational cohort.METHODS: In a cohort of patients with new-onset RA from northern Sweden (n = 665), the risk of CV disease was estimated by the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis (ERS-RA) and the American College of Cardiology/American Heart Association algorithm (ACC/AHA). The ACC/AHA estimation was analyzed, both as crude data and when adjusted according to the recommendations by the European League Against Rheumatism (ACC/AHA × 1.5). ERS-RA was calculated using 2 variants: 1 from patient and physician reports of hypertension (HTN) and hyperlipidemia [ERS-RA (reported)] and 1 from assessments of blood pressure (BP) and blood lipids [ERS-RA (measured)]. The estimations were compared with observed CV events.RESULTS: All variants of risk calculators underestimated the CV risk. Discrimination was good for all risk calculators studied. Performance of all risk calculators was poorer in patients with a high grade of inflammation, whereas ACC/AHA × 1.5 performed best in the high-inflammatory patients. In those patients with an estimated risk of 5-15%, no risk calculator performed well.CONCLUSION: ERS-RA underestimated the risk of a CV event in our cohort of patients, especially when risk estimations were based on patient or physician reports of HTN and hyperlipidemia instead of assessment of BP and blood lipids. The performance of ERS-RA was no better than that of ACC/AHA × 1.5, and neither performed well in high-inflammatory patients.
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| 38. |
- Wiklund, Jenny, 1975-
(författare)
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Journal - rekonstruktion av kropp och minne
- 2017
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Projektet har utvecklats i interdisciplinärt samarbete mellan Jenny Wiklund och KTH, Akademiska Sjukhuset i Uppsala, Uppsala Universitet, Karolinska Institutet, Kungl. Konsthögskolan, Aarhus Arkitektskole, och curator Jan Åman.Projektet har utvecklats skulpturalt vid Kungl. Konsthögskolan. Förstudier har genomförts vid Karolinska Universitetssjukhuset. I finalstudien kombineras studier vid Uppsala Akademiska Sjukhuset, Bild- och Funktionsmedicinskt centrum/Röntgen i tredimensionell visualisering av medicinsk bild med studier i klinisk anatomi vid Uppsala Universitet, för att förenas i skulptural gestaltning och iscensättning.R1 Reaktorhallen iscensätts som ett platsspecifikt monumentalverk. Den fysiska installationen i rummet bildar en temporal kappa om utställningskapitlen i avhandlingsutställningen som handlar om kropp och hjärna. Utställningen berättar om en specifik tidpunkt, utan minne och proprioception. Här finns ingen historia och ingen framtid.Genom utställningen skapas en förståelse för sambanden mellan teoretiskt tänkande och visuell gestaltning. Det är forskning genom konstnärlig och arkitektonisk precision med referenser till konst, arkitektur, medicin och medicinsk teknik. Referenserna är från verkliga objekt i verkliga rum, specifika verk från specifika konstnärer och genom auskultering vid flertalet expertpresentationer, där människor genom närvaro förmedlat sin kunskap.Arkitektur är spatial konstruktion av identitet, här i utställningsform som temporal visuell spatial-estetisk poetik. Formen på framläggningen av avhandlingen är vald efter det huvudsakliga ämnet som utreds, minnet, och dess temporala omskapande av rummet vid varje specifik tidpunkt det framkallas. Det visuella intrycket kommer före alla andra beskrivningar, i logik med den händelse som föregick doktorandprojektets ämne, en minnesförlust, där upplevelsen av rummet kom före språket, kroppen före hjärnan, intränade minnen i form av siffror före en självbiografi.
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| 39. |
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| 40. |
- Åkerfeldt, Anna, et al.
(författare)
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"Fridolin backar in i framtiden om digitala läromedel"
- 2021
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Ingår i: Dagens Nyheter. - 1101-2447. ; :2021-12-16
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Ingress: 23 forskare inom it- och utbildningsområdet: Regeringens utredare borde inte lyfta fram läsning på skärm som något negativt.Forskning visar att både tryckta och digitala läromedel behövs i skolan.
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| 41. |
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| 42. |
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