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1.	Reifarth, R., et al. (author) Nuclear astrophysics with radioactive ions at FAIR 2016 In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 665:1 Conference paper (peer-reviewed)abstract The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process beta-decay chains. These nuclei are attributed to the p and rp process. For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections. The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes.
2.	Aksyutina, Yu, et al. (author) Lithium isotopes beyond the drip line 2008 In: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 666:5, s. 430-434 Journal article (peer-reviewed)abstract The unbound isotopes 10Li, 12Li and 13Li have been observed after nucleon-knockout reactions at relativistic energies with 11Li and 14Be beams impinging on a liquid hydrogen target. The channels , and were analysed in the ALADIN-LAND setup at GSI. The 10Li data confirm earlier findings, while the 12Li and 13Li nuclei were observed for the first time. The relative-energy spectrum shows that the ground state of 12Li can be described as a virtual s-state with a scattering length of -13.7(1.6) fm. A broad energy spectrum was found for the channel. Based on the assumption that the relative-energy spectrum is dominated by a correlated background presumably stemming from initial correlations in the 14Be ground-state, evidence for a 13Li resonance at 1.47(31) MeV above the threshold with a width around 2 MeV has been found.
3.	Beceiro-Novo, S., et al. (author) Coulomb dissociation of 27 P: A reaction of astrophysical interest 2010 In: Proceedings of Science. - Trieste, Italy : Sissa Medialab. - 1824-8039. ; 100 Conference paper (peer-reviewed)abstract The ground-state decay of 26Al(0+) (T 1/2=1.05× 106) has a shorter life-time than the Universe. The presence of this element in the Galaxy was measured via g-ray spectroscopy, showing that the nucleosynthesis of this element is an ongoing process in stars. The proton-capture reaction 26Si(p,γ) 27P competes with the production of 26Al(0+) by β-decay. Coulomb dissociation of 27P has been suggested as an indirect method to measure radiative-proton capture when the direct reaction is not feasible. Such an experiment was performed at GSI with a secondary 27P beam produced by fragmenting a 36Ar primary beam at 500 A MeV. Two main observables are preliminarily presented in this work: the reaction cross section and the relative-energy spectrum of the outgoing fragments © Copyright owned by the author(s).
4.	Mahata, K., et al. (author) Study of dipole excitations and the single particle structure of neutron rich Ni isotopes 2008 In: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1012, s. 389-391 453 Conference paper (peer-reviewed)abstract An experiment was performed using the FRS-LAND setup at GSI to study the dipole strength distributions above neutron separation threshold for neutron-rich Ni isotopes. Measurements, using the same experimental setup, were also carried out to extract single particle occupancies via knockout reactions to investigate the structure and magicity of the neutron-rich Ni isotopes. The status of the data analysis and preliminary results are presented.
5.	Maierbeck, P., et al. (author) Probing the single particle structure around Ca-54 with one-neutron knock-out 2008 In: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1012, s. 89-93 Conference paper (peer-reviewed)abstract The nuclei Ca-47 and Ti-55 were populated in one-neutron knock-out reactions at relativistic energies. Momentum distributions of the residual nuclei as well as gamma-ray spectra were measured at the GSI fragment separator (FRS). Preliminary results of the ongoing analysis including cross sections and spin/parity assignments are presented.
6.	Maierbeck, P., et al. (author) Structure of 55Ti from relativistic one-neutron knockout 2009 In: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 675:1, s. 22-27 Journal article (peer-reviewed)abstract Results are presented from a one-neutron knockout reaction at relativistic energies on 56Ti using the GSI FRS as a two-stage magnetic spectrometer and the Miniball array for gamma-ray detection. Inclusive and exclusive longitudinal momentum distributions and cross-sections were measured enabling the determination of the orbital angular momentum of the populated states. First-time observation of the 955(6) keV -hole state in 55Ti is reported. The measured data for the first time proves that the ground state of 55Ti is a 1/2- state, in agreement with shell-model calculations using the GXPF1A interaction that predict a sizable N=34 gap in 54Ca.
7.	Marganiec, J, et al. (author) Experimental study of the 15O(2p ,γ)17Ne cross section by Coulomb Dissociation for the rp process 2016 In: Journal of Physics Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. Conference paper (peer-reviewed)abstract The time-reversed reaction 15O(2p,γ)17Ne has been studied by the Coulomb dissociation technique. Secondary 17Ne ion beams at 500 AMeV have been produced by fragmentation reactions of 20Ne in a beryllium production target and dissociated on a secondary Pb target. The incoming beam and the reaction products have been identified with the kinematically complete LAND-R3B experimental setup at GSI. The excitation energy prior to decay has been reconstructed by using the invariant-mass method. The preliminary differential and integral Coulomb Dissociation cross sections (σCoul) have been calculated, which provide a photoabsorption (σphoto) and a radiative capture cross section (σcap). Additionally, important information about the nuclear structure of the 17Ne nucleus will be obtained. The analysis is in progress.
8.	Novo, S. B., et al. (author) Coulomb Dissociation of 27P 2012 In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 381:1 Conference paper (peer-reviewed)abstract In this work the astrophysical 26Si(p,γ) 27P reaction is studied using the Coulomb dissociation technique. We performed a 27P Coulomb Dissociation experiment at GSI, Darmstadt (28 May-5 June 2007) using the ALADIN-LAND setup which allows complete-kinematic studies. A secondary 27P beam at 498 AMeV impinging a 515mg/cm 2 Pb target was used. The relative energy of the outgoing system ( 26Si+p) is measured obtaining the resonant states of the 27P. Preliminary results show four resonant states measured at 0.36±0.07, 0.88±0.09, 1.5±0.2, 2.3±0.3 MeV and evidence of a higher state at around 3.1 MeV. The preliminary total cross section obtained for relative energies between 0 and 3 MeV has been measured and yields 55±7 mb.
9.	Schwertel, S., et al. (author) One-neutron knockout from Sc51-55 2012 In: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-601X .- 1434-6001. ; 48:Dec., s. 191-10 Journal article (peer-reviewed)abstract Results are presented from a one-neutron knockout experiment at relativistic energies of approximate to 420 A MeV on Sc51-55 using the GSI Fragment Separator as a two-stage magnetic spectrometer and the Miniball array for gamma-ray detection. Inclusive longitudinal momentum distributions and cross-sections were measured enabling the determination of the contributions corresponding to knockout from the nu p(1/2), nu p(3/2), (L = 1) and nu f(7/2), nu f(5/2) (L = 3) neutron orbitals. The observed L = 1 and L = 3 contributions are compared with theoretical cross-sections using eikonal knockout theory and spectroscopic factors from shell model calculations using the GXPF1A interaction. The measured inclusive knockout cross-sections generally follow the trends expected theoretically and given by the spectroscopic strength predicted from the shell model calculations. However, the deduced L = 1 cross-sections are generally 30-40% higher while the L = 3 contributions are about a factor of two smaller than predicted. This points to a promotion of neutrons from the nu f(7/2) to the nu p(3/2) orbital indicating a weakening of the N = 28 shell gap in these nuclei. While this is not predicted for the phenomenological GXPF1A interaction such a weakening is predicted by recent calculations using realistic low-momentum interactions V-lowk obtained by evolving a chiral N3LO nucleon-nucleon potential.
10.	Aksouh, F., et al. (author) STUDY OF THE O-15(2p,gamma)Ne-17 CROSS SECTION BY COULOMB DISSOCIATION OF Ne-17 FOR THE rp PROCESS OF NUCLEOSYNTHESIS 2014 In: Acta Physica Polonica, Series B.. - 1509-5770 .- 0587-4254. ; 45:2, s. 229-234 Journal article (peer-reviewed)abstract The O-15(2p, gamma)Ne-17 cross section has been studied by the inverse reaction, the Coulomb dissociation of Ne-17. The experiment has been performed at the GSI. The Ne-17 excitation energy prior to decay has been reconstructed by using the invariant-mass method. The preliminary differential and integral Coulomb dissociation cross sections (sigma(Coul)) have been extracted, which provide a photoabsorption (sigma(photo)) and a radiative capture cross section (sigma(cap)). Additionally, important information about the Ne-17 nuclear structure will be obtained. The analysis is in progress.
11.	Aksyutina, Y., et al. (author) Momentum profile analysis in one-neutron knockout from Borromean nuclei 2013 In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 718:4-5, s. 1309-1313 Journal article (peer-reviewed)abstract One-neutron knockout reactions from Borromean nuclei are analyzed using a profile function analysis technique. The profile function, which is derived as the square root of the variance of the measured fragment + neutron momenta as a function of their relative energy, is shown to be very sensitive to the angular momentum of the knocked out neutron. Three cases are studied here: He-7, where the profile function analysis shows a presence of (s(1/2))(2) component in the He-8 ground-state wave-function, Li-10, where the presence of a 11(2)% d-wave contribution to the relative energy spectrum above 1.5 MeV is found and, finally, the presence of a major s contribution around 0.5 MeV relative energy in the Be-13 case and that the observed decay to the Be-12 2(+) state originates in a d state in Be-13.
12.	Aksyutina, Yuliya, 1983, et al. (author) Properties of the 7He ground state from 8He neutron knockout 2009 In: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 679:3, s. 191-196 Journal article (peer-reviewed)abstract The unbound nucleus 7He, produced in neutron-knockout reactions with a 240 MeV/u 8He beam in a liquid-hydrogen target, has been studied in an experiment at the ALADIN-LAND setup at GSI. From an R-matrix analysis the resonance parameters for 7He as well as the spectroscopic factor for the 6He(0+) + n configuration in its ground-state have been obtained. The spectroscopic factor is 0.61 confirming that 7He is not a pure single-particle state. An analysis of 5He data from neutron-knockout reactions of 6He in a carbon target reveals the presence of an s-wave component at low energies in the α+n relative energy spectrum. A possible low-lying exited state in 7He observed in neutron knockout data from 8He in a carbon target and tentatively interpreted as a Iπ=1/2− state, could not be observed in the present experiment. Possible explanations of the shape difference between the 7He resonance obtained in the two knockout reactions are discussed in terms of target-dependence or different reaction mechanisms at relativistic energies.
13.	Aksyutina, Y., et al. (author) Structure of the unbound nucleus Be-13: One-neutron knockout reaction data from Be-14 analyzed in a holistic approach 2013 In: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 87:6 Journal article (peer-reviewed)abstract At the ALADIN-LAND setup at GSI the unbound nucleus Be-13 has been produced in one-neutron knockout reactions from a 304 MeV/nucleon relativistic beam of Be-14 ions impinging on a liquid hydrogen target. An analysis of the data including all available information about Be-13, and in particular recent data from a similar experiment performed at RIKEN, has been performed. A consistent description is reached. It is found that the excitation spectrum is dominated by s-waves at low energy, which solves problems from previous seemingly contradictory interpretations. A possible interference between two s-states in Be-13 is also discussed. The results indicate that the ground-state wave function of Be-14 is dominated by valence neutrons in the s-shell contributing with 60-75% of the total neutron knockout cross section.
14.	Aksyutina, Y., et al. (author) Study of the Be14 continuum: Identification and structure of its second 2+ state 2013 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 111:24, s. article nr. 242501- Journal article (peer-reviewed)abstract The coupling between bound quantum states and those in the continuum is of high theoretical interest. Experimental studies of bound drip-line nuclei provide ideal testing grounds for such investigations since they, due to the feeble binding energy of their valence particles, are easy to excite into the continuum. In this Letter, continuum states in the heaviest particle-stable Be isotope, Be14, are studied by employing the method of inelastic proton scattering in inverse kinematics. New continuum states are found at excitation energies E=3.54(16) MeV and E=5.25(19) MeV. The structure of the earlier known 21+ state at 1.54(13) MeV was confirmed with a predominantly (0d5/2)2 configuration while there is very clear evidence that the 22+ state has a predominant (1s1/2, 0d 5/2) structure with a preferential three-body decay mechanism. The region at about 7 MeV excitation shows distinct features of sequential neutron decay via intermediate states in Be13. This demonstrates that the increasing availability of energetic beams of exotic nuclei opens up new vistas for experiments leading towards a new understanding of the interplay between bound and continuum states. © 2013 American Physical Society.
15.	Johansson, Håkan T, 1977, et al. (author) The unbound isotopes He-9,He-10 2010 In: Nuclear Physics A. - Elsevier : Elsevier BV. - 0375-9474 .- 1873-1554. ; 842:1-4, s. 15-32 Journal article (peer-reviewed)abstract The unbound nuclei He-9 and He-10 have been produced in proton-knockout reactions from a 280 MeV/u Li-11 beam impinging on a liquid hydrogen target at the ALADIN-LAND setup at GSI. Information on their nuclear structure has been obtained from the relative-energy spectra, He-8 + n and He-8 + 2n, employing reaction models incorporating the structure of Li-11. The (8H)e + n relative-energy spectrum is dominated by a strong peak-like structure at low energy, which may be interpreted within the effective-range approximation as the result of an s-wave interaction with a neutron scattering length of -3.17(66) fm. This spectrum also shows evidence for resonance states at 1.33(8) MeV and at 2.4 MeV above the He-8 + n threshold. It is argued that the s-state might not be the He-9 ground state. For He-8 + n + n, the analysis of the relative-energy spectrum gives two alternative possibilities for an interpretation: either a narrow resonance at 1.42(10) MeV (Gamma = 1.11(76) MeV) superimposed on a correlated background, or two overlapping resonances, a ground state at 1.54(11) MeV (Gamma = 1.91(41) MeV) together with an excited state at 3.99(26) MeV (Gamma = 1.64(89) MeV). The two possible interpretations are discussed. (C) 2010 Elsevier B.V. All rights reserved.
16.	Johansson, Håkan T, 1977, et al. (author) Three-body correlations in the decay of He-10 and Li-13 2010 In: Nuclear Physics A. - Elsevier : Elsevier BV. - 0375-9474 .- 1873-1554. ; 847:1-2, s. 66-88 Journal article (peer-reviewed)
17.	Klimkiewicz, A., et al. (author) Pygmy Dipole Strength in Exotic Nuclei and the Equation of State 2009 In: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1165, s. 181-184 461 Conference paper (peer-reviewed)abstract A concentration of dipole strength at energies below the giant dipole resonance was observed in neutron-rich nuclei around Sn-132 in an experiment using the FRS-LAND setup. This so-called "pygmy" dipole strength can be related to the parameters of the symmetry energy and to the neutron skin thickness on the grounds of a relativistic quasiparticle random-phase approximation. Using this ansatz and the experimental findings for Sn-130 and 132 Sri, we derive a value of the symmetry energy pressure of (p) over bar (0) = 2.2 +/- 0.5 MeV/fm(3). Neutron skin thicknesses of R-n-R-p = 0.23 +/- 0.03 fm and 0.24 +/- 0.03 fm for Sn-130 and Sn-132, respectively, have been determined. Preliminary results on Ni-68 from a similar experiment using an improved setup indicate an enhanced cross section at low energies, while the results for Ni-58 are in accordance with results from photoabsorption measurements.
18.	Lehr, C., et al. (author) Unveiling the two-proton halo character of 17 Ne: Exclusive measurement of quasi-free proton-knockout reactions 2022 In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 827 Journal article (peer-reviewed)abstract The proton drip-line nucleus 17Ne is investigated experimentally in order to determine its two-proton halo character. A fully exclusive measurement of the 17Ne(p,2p)16F→15⁎O+p quasi-free one-proton knockout reaction has been performed at GSI at around 500 MeV/nucleon beam energy. All particles resulting from the scattering process have been detected. The relevant reconstructed quantities are the angles of the two protons scattered in quasi-elastic kinematics, the decay of 16F into 15O (including γ decays from excited states) and a proton, as well as the 15O+p relative-energy spectrum and the 16F momentum distributions. The latter two quantities allow an independent and consistent determination of the fractions of l=0 and l=2 motion of the valence protons in 17Ne. With a resulting relatively small l=0 component of only around 35(3)%, it is concluded that 17Ne exhibits a rather modest halo character only. The quantitative agreement of the two values deduced from the energy spectrum and the momentum distributions supports the theoretical treatment of the calculation of momentum distributions after quasi-free knockout reactions at high energies by taking into account distortions based on the Glauber theory. Moreover, the experimental data allow the separation of valence-proton knockout and knockout from the 15O core. The latter process contributes with 11.8(3.1) mb around 40% to the total proton-knockout cross section of 30.3(2.3) mb, which explains previously reported contradicting conclusions derived from inclusive cross sections.
19.	Marganiec, C., et al. (author) Coulomb breakup of 17Ne from the viewpoint of nuclear astrophysics 2013 In: Proceedings of Science. Conference paper (peer-reviewed)abstract By the Coulomb breakup of 17Ne, the time-reversed reaction 15O(2p,γ)17Ne has been studied. This reaction might play an important role in the rp process, as a break-out reaction of the hot CNO cycle. The secondary 17Ne ion beam with an energy of 500 MeV/nucleon has been dissociated in a Pb target. The reaction products have been detected with the LAND-R3B experimental setup at GSI. The preliminary differential and integral Coulomb dissociation cross section sCoul has been determined, which then will be converted into a photo-absorption cross section sphot o, and a two-proton radiative capture cross section σcap. Additionally, information about the structure of the 17Ne, a potential two-proton halo nucleus, will be received. The analysis is in progress.
20.	Marganiec, J., et al. (author) Coulomb and nuclear excitations of narrow resonances in 17Ne 2016 In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 759, s. 200-205 Journal article (peer-reviewed)abstract New experimental data for dissociation of relativistic 17Ne projectiles incident on targets of lead, carbon, and polyethylene targets at GSI are presented. Special attention is paid to the excitation and decay of narrow resonant states in 17Ne. Distributions of internal energy in the O15+p+p three-body system have been determined together with angular and partial-energy correlations between the decay products in different energy regions. The analysis was done using existing experimental data on 17Ne and its mirror nucleus 17N. The isobaric multiplet mass equation is used for assignment of observed resonances and their spins and parities. A combination of data from the heavy and light targets yielded cross sections and transition probabilities for the Coulomb excitations of the narrow resonant states. The resulting transition probabilities provide information relevant for a better understanding of the 17Ne structure.
21.	Marganiec, J., et al. (author) Coulomb dissociation of P-27 at 500 MeV/u 2016 In: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 93:4 Journal article (peer-reviewed)abstract The proton-capture reaction Si-26(p,gamma)(27) P was studied via Coulomb dissociation (CD) of P-27 at an incident energy of about 500 MeV/u. The three lowest-lying resonances in P-27 have been populated and their resonance strengths have been measured. In addition, a nonresonant direct-capture component was clearly identified and its astrophysical S factor measured. The experimental results are compared to Monte Carlo simulations of the CD process using a semiclassical model. Our thermonuclear reaction rates show good agreement with the rates from a recent compilation. With respect to the nuclear structure of P-27 we have found evidence for a negative-parity intruder state at 2.88-MeV excitation energy.
22.	Marganiec, J., et al. (author) Experimental study of the O-15(2p, gamma) Ne-17 cross section by Coulomb Dissociation for the rp process 2016 In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 665:1 Conference paper (peer-reviewed)abstract The time-reversed reaction O-15(2p, gamma) Ne-17 has been studied by the Coulomb dissociation technique. Secondary 17Ne ion beams at 500 AMeV have been produced by fragmentation reactions of Ne-20 in a beryllium production target and dissociated on a secondary Pb target. The incoming beam and the reaction products have been identified with the kinematically complete LAND-(RB)-B-3 experimental setup at GSI. The excitation energy prior to decay has been reconstructed by using the invariant-mass method. The preliminary differential and integral Coulomb Dissociation cross sections (sigma(Coul)) have been calculated, which provide a photoabsorption (sigma(photo)) and a radiative capture cross section (sigma(cap)). Additionally, important information about the nuclear structure of the Ne-17 nucleus will be obtained. The analysis is in progress.
23.	Marganiec, J., et al. (author) Studies of continuum states in (16) Ne using three-body correlation techniques 2015 In: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-601X .- 1434-6001. ; 51:1, s. 1-9 Journal article (peer-reviewed)abstract Two-proton decay of the unbound nucleus Ne-16 , produced in one-neutron knockout from a 500 MeV/u Ne-17 beam, has been studied at GSI. The ground state, at a resonance energy 1.388(15) MeV, ( MeV) above the O-14 +p+p threshold, and two narrow resonances at MeV and 7.57(6) MeV have been investigated. A comparison of the energy difference between the first excited 2(+) state and the 0(+) ground state in Ne-16 with its mirror nucleus C-16 reveals a small Thomas-Ehrman shift (TES) of keV. A trend of the TES for the T = 2 quintet is obtained by completing the known data with a prediction for F-16 obtained from an IMME analysis. The decay mechanisms of the observed three resonances were revealed from an analysis of the energy and angular correlations of the O-14 +p+p decay products. The ground state decay can be considered as a genuine three-body (democratic) mode and the excited states decay sequentially via states in the intermediate nucleus F-15 , the 3.22 MeV state predominantly via the F-15 ground-state resonance, while the 7.57 MeV state decays via the 5/2(+) resonance in F-15 at 2.8 MeV above the O-14 +p+p threshold. Further, from an analysis of angular correlations, the spin-parity of the 7.57 MeV state has been determined as and assigned as the third 2(+) state in Ne-16 based on a comparison with C-16.
24.	Wamers, F., et al. (author) Comparison of electromagnetic and nuclear dissociation of Ne-17 2018 In: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 97:3 Journal article (peer-reviewed)abstract The Borromean drip-line nucleus Ne-17 has been suggested to possess a two-proton halo structure in its ground state. In the astrophysical rp-process, where the two-proton capture reaction O-15(2p,gamma) Ne-17 plays an important role, the calculated reaction rate differs by several orders of magnitude between different theoretical approaches. To add to the understanding of the Ne-17 structure we have studied nuclear and electromagnetic dissociation. A 500 MeV/u Ne-17 beam was directed toward lead, carbon, and polyethylene targets. Oxygen isotopes in the final state were measured in coincidence with one or two protons. Different reaction branches in the dissociation of Ne-17 were disentangled. The relative populations of s and d states in F-16 were determined for light and heavy targets. The differential cross section for electromagnetic dissociation (EMD) shows a continuous internal energy spectrum in the three-body system O-15 + 2p. The Ne-17 EMD data were compared to current theoretical models. None of them, however, yields satisfactory agreement with the experimental data presented here. These new data may facilitate future development of adequate models for description of the fragmentation process.
25.	Wamers, F., et al. (author) Comparison of electromagnetic and nuclear dissociation of Ne 17 2018 In: Physical Review C. - 2469-9985 .- 2469-9993. ; 97:3 Journal article (peer-reviewed)abstract The Borromean drip-line nucleus Ne17 has been suggested to possess a two-proton halo structure in its ground state. In the astrophysical rp-process, where the two-proton capture reaction O15(2p,γ)Ne17 plays an important role, the calculated reaction rate differs by several orders of magnitude between different theoretical approaches. To add to the understanding of the Ne17 structure we have studied nuclear and electromagnetic dissociation. A 500 MeV/u Ne17 beam was directed toward lead, carbon, and polyethylene targets. Oxygen isotopes in the final state were measured in coincidence with one or two protons. Different reaction branches in the dissociation of Ne17 were disentangled. The relative populations of s and d states in F16 were determined for light and heavy targets. The differential cross section for electromagnetic dissociation (EMD) shows a continuous internal energy spectrum in the three-body system O15+2p. The Ne17 EMD data were compared to current theoretical models. None of them, however, yields satisfactory agreement with the experimental data presented here. These new data may facilitate future development of adequate models for description of the fragmentation process.
26.	Wamers, F., et al. (author) Diverse mechanisms in proton knockout reactions from the Borromean nucleus Ne-17 2023 In: European Physical Journal A. - : Springer. - 1434-6001 .- 1434-601X. ; 59 Journal article (peer-reviewed)abstract Nucleon knockout experiments using beryllium or carbon targets reveal a strong dependence of the quenching factors, i.e., the ratio (Rs) of theoretical to the experimental spectroscopic factors (C2S), on the proton-neutron asymmetry in the nucleus under study. However, this dependence is greatly reduced when a hydrogen target is used. To understand this phenomenon, exclusive H-1(Ne-17, 2p F-16) and inclusive C-12(Ne-17, 2p 1(6)F)X, 1(2)C(Ne-17, F-16)X as well as 1H(Ne-17,(16) F)X(X-denotes undetected reaction products) reactions with F-16 in the ground and excited states were anal- ysed. The longitudinal momentum distribution of F-16 and the correlations between the detached protons were studied. In the case of the carbon target, there is a significant deviation from the predictions of the eikonal model. The eikonal approximation was used to extract spectroscopic factor values (CS)-S-2. The experimental (CS)-S-2 value obtained with C target is markedly lower than that for H target. This is interpreted as rescattering due to simultaneous nucleon knockout from both reaction partners, Ne-17 and C-12.
27.	Wamers, F., et al. (author) Exclusive measurements of nuclear breakup reactions of 17Ne 2014 In: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 66 Conference paper (peer-reviewed)abstract We have studied one-proton-removal reactions of about 500MeV/u 17Ne beams on a carbon target at the R3B/LAND setup at GSI by detecting beam-like 15O-p and determining their relative-energy distribution. We exclusively selected the removal of a 17Ne halo proton, and the Glauber-model analysis of the 16F momentum distribution resulted in an s2 contribution in the 17Ne ground state of about 40%. © Owned by the authors, published by EDP Sciences, 2014.
28.	Wamers, F., et al. (author) First Observation of the Unbound Nucleus Ne-15 2014 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:13 Journal article (peer-reviewed)abstract We report on the first observation of the unbound proton-rich nucleus Ne-15. Its ground state and first excited state were populated in two-neutron knockout reactions from a beam of 500 MeV/u Ne-17. The Ne-15 ground state is found to be unbound by 2.522(66) MeV. The decay proceeds directly to O-13 with simultaneous two-proton emission. No evidence for sequential decay via the energetically allowed 2(-) and 1(-) states in F-14 is observed. The Ne-15 ground state is shown to have a strong configuration with two protons in the (sd) shell around O-13 with a 63(5)% (1s(1/2))(2) component.
29.	Wamers, F., et al. (author) New insight into knockout reactions from the two-proton halo nucleus Ne 17 2024 In: Physical Review C. - 2469-9985 .- 2469-9993. ; 109:5 Journal article (peer-reviewed)abstract Background: The unexplained disagreement in the dependence of spectroscopic factors (C2Sexp) on the binding energy obtained by nucleon knockout using different targets is still a puzzle that needs to be addressed. Purpose: To find an explanation of this riddle through exclusive measurements using different targets. Method: The exclusive measurements were performed by using a Ne17 beam with an energy of 500 MeV/u incident on C and CH2 targets. Through the standard theoretical approach, C2Sexp were derived from the analysis of the experimental data on proton ejection from the proton halo in Ne17 as well as from its core O15. Result: For the C target, proton ejection from the proton halo gave C2Sexp about 37% smaller than for the H target. But when protons are ejected from the core of Ne17, C2Sexp are identical within statistical uncertainties. Conclusion: An explanation for the difference in C2Sexp could be the removal of both halo protons, a more important reaction pathway for the C target. The C2Sexp values obtained by analyzing the proton ejection from the core indicate that it is not affected by the interaction with the halo protons.
30.	Langer, C., et al. (author) Thermonuclear reaction S-30(p,gamma)Cl-31 studied via Coulomb breakup of Cl-31 2014 In: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 89:3 Journal article (peer-reviewed)abstract Coulomb breakup at high energy in inverse kinematics of proton-rich Cl-31 was used to constrain the thermonuclear S-30(p,gamma)Cl-31 capture reaction rate under typical Type I x-ray burst conditions. This reaction is a bottleneck during rapid proton-capture nucleosynthesis (rp process), where its rate depends predominantly on the nuclear structure of Cl-31. Two low-lying states just above the proton-separation threshold of S-p = 296( 50) keV in Cl-31 have been identified experimentally using the (RB)-B-3-LAND setup at the GSI Helmholtzzentrum fur Schwerionenforschung GmbH. Both states are considered to play a key role in the thermonuclear S-30( p,gamma)Cl-31 capture reaction. Excitation energies of the first J(pi) = 1/2(+), 5/2(+) states have been extracted and the reaction rate for proton capture on S-30 under typical rp-process temperatures has been investigated.
31.	Le Bleis, T., et al. (author) Target dependence in the study of collective modes in stable and exotic Ni nuclei 2010 In: Journal of Physics: Conference Series. ; 202:1, s. 012035- Conference paper (peer-reviewed)abstract The appearance of the pygmy-dipole-resonance is a recently observed phenomenon that can be related to neutron-matter properties. Its study can be a tool to determine the nuclear symmetry-energy parameters and thus can contribute constraining neutron star models. We present the ( γ,n ) cross sections for different Ni isotopes obtained from a measurement in inverse kinematics at about 500 MeV/u in the LAND reaction setup at GSI. The question of the disentanglement of the Coulomb and nuclear contributions is addressed.
32.	Marganiec, J., et al. (author) Coulomb breakup of 17Ne from the viewpoint of nuclear astrophysics 2012 In: Proceedings of Science. - Proceedings of Science : Sissa. - 1824-8039. Conference paper (peer-reviewed)abstract By the Coulomb breakup of 17Ne, the time-reversed reaction 15O(2p,γ)17Ne has been studied. This reaction might play an important role in the rp process, as a break-out reaction of the hot CNO cycle. The secondary 17Ne ion beam with an energy of 500 MeV/nucleon has been dissociated in a Pb target. The reaction products have been detected with the LAND-R3B experimental setup at GSI. The preliminary differential and integral Coulomb dissociation cross section sCoul has been determined, which then will be converted into a photo-absorption cross section sphoto, and a two-proton radiative capture cross section σcap. Additionally, information about the structure of the 17Ne, a potential two-proton halo nucleus, will be received. The analysis is in progress. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.
33.	Marganiec, J., et al. (author) Coulomb Dissociation experiment of 27P 2015 In: Acta Physica Polonica, Series B.. - 1509-5770 .- 0587-4254. ; 46:3, s. 473-476 Journal article (peer-reviewed)abstract The 26Si(p; γ)27P reaction, which might play an important role in the rp process, was studied by the Coulomb Dissociation method. The experiment was performed at GSI, Darmstadt. A secondary 27P ion beam of 500 MeV/nucleon was directed onto a Pb target. From this experiment, the Coulomb Dissociation cross section, σCoulex, will be deduced and then converted to the photoabsorption cross section, σphoto, and the radiativecapture cross section, σcap. Also information on the structure of 27P will be obtained. The analysis is in progress.
34.	Rao, Fangwen, et al. (author) Catecholamine release-inhibitory peptide catestatin (chromogranin A352-372) : Naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension 2007 In: Circulation. - 0009-7322 .- 1524-4539. ; 115:17, s. 2271-2281 Journal article (peer-reviewed)abstract BACKGROUND - Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. We identified a natural nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and blood pressure. METHODS AND RESULTS - Gly364Ser heterozygotes and controls underwent physiological and biochemical phenotyping, including catecholamine production, chromogranin A precursor, and its catestatin product. Case-control studies replicated effects of the gene on blood pressure in the population. Gly364Ser displayed diminished inhibition of catecholamine secretion from cultured neurons. Gly/Ser heterozygotes displayed increased baroreceptor slope during upward deflections (by ≈47%) and downward deflections (by ≈44%), increased cardiac parasympathetic index (by ≈2.4-fold), and decreased cardiac sympathetic index (by ≈26%). Renal norepinephrine excretion was diminished by ≈26% and epinephrine excretion by ≈34% in Gly/Ser heterozygotes. The coalescent dated emergence of the variant to ≈70 000 years ago. Gly364Ser was in linkage disequilibrium with 1 major Chromogranin A promoter haplotype, although promoter haplotypes did not predict autonomic phenotypes. The 364Ser variant was associated with lower diastolic blood pressure in 2 independent/confirmatory groups of patients with hypertension; genotype groups differed by ≈5 to 6 mm Hg, and the polymorphism accounted for ≈1.8% of population diastolic blood pressure variance, although a significant gene-by-sex interaction existed, with an enhanced effect in men. CONCLUSIONS - The catestatin Gly364Ser variant causes profound changes in human autonomic activity, both parasympathetic and sympathetic, and seems to reduce risk of developing hypertension, especially in men. A model for catestatin action in the baroreceptor center of the nucleus of the tractus solitarius accounts for these actions.
35.	Rossi, D., et al. (author) Coulomb excitation of exotic nuclei at the R3B-LAND setup 2013 In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 420:1 Conference paper (peer-reviewed)abstract Exotic Ni isotopes have been measured at the R3B-LAND setup at GSI in Darmstadt, using Coulomb excitation in inverse kinematics at beam energies around 500 MeV/u. As the experimental setup allows kinematically complete measurements, the excitation energy was reconstructed using the invariant mass method. The GDR and additional low-lying strength have been observed in 68Ni, the latter exhausting 4.1(1.9)% of the E1 energy-weighted sum rule. Also, the branching ratio for the non-statistical decay of the excited 68Ni nuclei was measured and amounts to 24(4)%.
36.	Rossi, D. M., et al. (author) Investigation of the Dipole Response in Exotic Nuclei-Experiments at the LAND-(RB)-B-3 Setup 2012 In: Progress of Theoretical Physics Supplement. - 0375-9687. ; :196, s. 465-470 Conference paper (peer-reviewed)abstract We present experimental results on the electromagnetic excitation of neutron-rich nickel isotopes, making use of the (RB)-B-3-LAND setup at GSI. Exotic beams were produced at approximately 500 MeV/u and their reactions were studied in inverse kinematics. Integral cross sections for Ni-58 are discussed and compared to previous data, providing a validation of our experimental method. The El excitation-energy distribution of the unstable Ni-68 is presented as well, showing an excess in cross section in the 1n decay channel when compared only with a typical Giant Dipole Resonance.
37.	Rossi, D., et al. (author) Measurement of the dipole polarizability of the unstable neutron-rich nucleus Ni68 2013 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 111:24 Journal article (peer-reviewed)abstract The E1 strength distribution in Ni68 has been investigated using Coulomb excitation in inverse kinematics at the RB3-LAND setup and by measuring the invariant mass in the one- and two-neutron decay channels. The giant dipole resonance and a low-lying peak (pygmy dipole resonance) have been observed at 17.1(2) and 9.55(17) MeV, respectively. The measured dipole polarizability is compared to relativistic random phase approximation calculations yielding a neutron-skin thickness of 0.17(2) fm. A method and analysis applicable to neutron-rich nuclei has been developed, allowing for a precise determination of neutron skins in nuclei as a function of neutron excess.
38.	Salem, Rany M., et al. (author) Chromogranin a polymorphisms are associated with hypertensive renal disease 2008 In: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 19:3, s. 600-614 Journal article (peer-reviewed)abstract Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells. Specific endopeptidases cleave chromogranin A into biologically active peptide fragments, including catestatin, which inhibits catecholamine release. Previous studies have suggested that a deficit in this sympathetic “braking” system might be an early event in the pathogenesis of human hypertension. Whether chromogranin A (CHGA) polymorphisms predict end-organ complications of hypertension, such as end-stage renal disease, is unknown. Among blacks, we studied common genetic variants spanning the CHGA locus in 2 independent case-control studies of hypertensive ESRD. Two haplotypes were significantly more frequent among subjects with hypertensive ESRD: 1) in the promoter (5′) region, G-462A→T-415C→C-89A, haplotype ATC (adjusted odds ratio = 2.65; P = 0.037), and 2) at the 3′-end, C11825T (3′-UTR, C+87T)→G12602C, haplotype TC (adjusted odds ratio = 2.73, P = 0.0196). Circulating levels of catestatin were lower among those with hypertensive ESRD than controls, an unexpected finding given that peptide levels are usually elevated in ESRD because of reduced renal elimination. We found that the 3′-UTR + 87T variant decreased reporter gene expression, providing a possible mechanistic explanation for diminished catestatin. In summary, common variants in chromogranin A associate with the risk of hypertensive ESRD in blacks.
39.	Zhang, Kuixing, et al. (author) Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B 2009 In: Circulation: Cardiovascular Genetics. - 1942-3268. ; 2:1, s. 46-56 Journal article (peer-reviewed)abstract Background: Hypertension is a complex trait, with deranged autonomic control of circulation. Chromogranin B (CHGB) is the most abundant core protein in human catecholamine secretory vesicles, playing an important role in their biogenesis. Does common interindividual variation at the CHGB locus contribute to phenotypic variation in CHGB and catecholamine secretion, autonomic stability of circulation, or blood pressure (BP) in the population? Methods and Results: To probe interindividual variability in CHGB, we systematically studied polymorphism across the locus by resequencing CHGB (≈6 kbp footprint spanning the promoter, 5 exons, exon/intron borders, untranslated regions) in 160 subjects (2n=320 chromosomes) of diverse biogeographic ancestries. We identified 53 single-nucleotide polymorphisms, of which 22 were common. We then studied 1182 subjects drawn from the most extreme BP values in the population (highest and lowest 5th percentiles), typing 4 common polymorphisms spanning the ≈14 kbp locus. Sliding-window haplotype analysis indicated BP associations peaking in the 5'/promoter region, most prominent in men, and a peak effect in the proximal promoter at variant A-261T (A>T), accounting for ≈8/≈6 mm Hg BP in males. The promoter allele (A-261) that was a predictor of higher diastolic BP and systolic BP was also associated with lower circulating/plasma CHGB concentration (CHGB439to451 epitope) in twin pairs. In twins, the same CHGB variants that were predictors of lower basal CHGB secretion were also associated with exaggerated catecholamine secretion and BP response to environmental (cold) stress; likewise, women displayed increased plasma CHGB439to451 but decreased catecholamine secretion as well as BP response to environmental stress. The effect of A-261T on CHGB expression was confirmed in chromaffin cells by site-directed mutagenesis on transfected CHGB promoter/luciferase reporter activity, and the allelic effects of A-261T on gene expression were directionally coordinate in cella and in vivo. To confirm these clinical associations experimentally, we undertook targeted homozygous (-/-) ablation of the mouse CHGB gene; knockout mice displayed substantially increased BP, by ≈20/≈18 mm Hg, confirming the mechanistic basis of our findings in humans. Conclusion-Common genetic variation at the CHGB locus, especially in the proximal promoter, influences CHGB expression and later catecholamine secretion and the early heritable responses to environmental stress, eventuating in changes in resting/basal BP in the population. Both the early (gene expression) and late (population BP) consequences of CHGB variation are sex dependent. These results point to new molecular strategies for probing autonomic control of circulation and, ultimately, the susceptibility to and pathogenesis of cardiovascular disease states such as hypertension.
40.	Chen, Yuqing, et al. (author) Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis 2009 In: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 20:7, s. 1623-1632 Journal article (peer-reviewed)abstract Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells. CHGA polymorphisms associate with an increased risk for ESRD, but whether altered CHGA-endothelium interactions may explain this association is unknown. Here, CHGA led to the release of endothelin-1 and Weibel-Palade body exocytosis in cultured human umbilical vein endothelial cells. In addition, CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells. In humans, plasma CHGA correlated positively with endothelin-1 and negatively with GFR. GFR was highly heritable in twin pairs, and common promoter haplotypes of CHGA predicted GFR. In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function.
41.	Chen, Yuqing, et al. (author) Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion 2008 In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 52:18, s. 1468-81 Journal article (peer-reviewed)abstract OBJECTIVES: We aimed to determine whether the common variation at the chromogranin A (CHGA) locus increases susceptibility to hypertension. BACKGROUND: CHGA regulates catecholamine storage and release. Previously we systematically identified genetic variants across CHGA. METHODS: We carried out dense genotyping across the CHGA locus in >1,000 individuals with the most extreme blood pressures (BPs) in the population, as well as twin pairs with autonomic phenotypes. We also characterized the function of a trait-associated 3'-untranslated region (3'-UTR) variant with transfected CHGA 3'-UTR/luciferase reporter plasmids. RESULTS: CHGA was overexpressed in patients with hypertension, especially hypertensive men, and CHGA predicted catecholamines. In individuals with extreme BPs, CHGA genetic variants predicted BP, especially in men, with a peak association occurring in the 3'-UTR at C+87T, accounting for up to approximately 12/ approximately 9 mm Hg. The C+87T genotype predicted CHGA secretion in vivo, with the +87T allele (associated with lower BP) also diminishing plasma CHGA by approximately 10%. The C+87T 3'-UTR variant also predicted the BP response to environmental (cold) stress; the same allele (+87T) that diminished basal BP in the population also decreased the systolic BP response to stress by approximately 12 mm Hg, and the response was smaller in women (by approximately 6 mm Hg). In a chromaffin cell-transfected CHGA 3'-UTR/luciferase reporter plasmid, the +87T allele associated with lower BP also decreased reporter expression by approximately 30%. In cultured chromaffin cells, reducing endogenous CHGA expression by small interfering ribonucleic acid caused approximately two-thirds depletion of catecholamine storage vesicles. CONCLUSIONS: Common variant C+87T in the CHGA 3'-UTR is a functional polymorphism causally associated with hypertension especially in men of the population, and we propose steps ("intermediate phenotypes") whereby in a sex-dependent fashion this genetic variant influences the ultimate disease trait. These observations suggest new molecular strategies to probe the pathophysiology, risk, and rational treatment of hypertension.
42.	Greenwood, Tiffany A, et al. (author) Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion. 2006 In: Physiol Genomics. - 1531-2267. ; 25:3, s. 470-9 Journal article (peer-reviewed)
43.	O'Connor, Daniel T., et al. (author) Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a : implications for secretion and blood pressure 2008 In: Circulation. - 0009-7322 .- 1524-4539. ; 118:3, s. 247-57 Journal article (peer-reviewed)abstract BACKGROUND: Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragment inhibits catecholamine release. We approached catestatin heritability using twin pairs, coupled with genome-wide linkage, in a series of twin and sibling pairs from 2 continents. METHODS AND RESULTS: Hypertensive patients had elevated CHGA coupled with reduction in catestatin, suggesting diminished conversion of precursor to catestatin. Heritability for catestatin in twins was 44% to 60%. Six hundred fifteen nuclear families yielded 870 sib pairs for linkage, with significant logarithm of odds peaks on chromosomes 4p, 4q, and 17q. Because acidification of catecholamine secretory vesicles determines CHGA trafficking and processing to catestatin, we genotyped at positional candidate ATP6N1, bracketed by peak linkage markers on chromosome 17q, encoding a subunit of vesicular H(+)-translocating ATPase. The minor allele diminished CHGA secretion and processing to catestatin. The ATP6N1 variant also influenced blood pressure in 1178 individuals with the most extreme blood pressure values in the population. In chromaffin cells, inhibition of H(+)-ATPase diverted CHGA from regulated to constitutive secretory pathways. CONCLUSIONS: We established heritability of catestatin in twins from 2 continents. Linkage identified 3 regions contributing to catestatin, likely novel determinants of sympathochromaffin exocytosis. At 1 such positional candidate (ATP6N1), variation influenced CHGA secretion and processing to catestatin, confirming the mechanism of a novel trans-QTL for sympathochromaffin activity and blood pressure.
44.	Rana, Brinda K., et al. (author) Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24 : influence on heritable autonomic traits in twin pairs 2009 In: Journal of Pharmacology and Experimental Therapeutics. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0022-3565 .- 1521-0103. ; 331:2, s. 419-428 Journal article (peer-reviewed)abstract Nicotinic acetylcholine receptors (nAChRs) are combinations of subunits arranged as pentamers encircling a central cation channel. At least nine α and four β subunits are expressed in the central and peripheral nervous systems; their presence in autonomic ganglia, the adrenal medulla, and central nervous system, with accompanying responses elicited by nicotinic agonists, point to their involvement in cardiovascular homeostasis. nAChRs formed by α3, α5, and β4 subunits may regulate blood pressure (BP) by mediating release of catestatin, the endogenous nicotinic antagonist fragment of chromogranin A (CHGA) and potent inhibitor of catecholamine secretion. Genes encoding these subunits (CHRNA3, CHRNA5, and CHRNB4) are clustered on human chromosome 15q24. Because variation in this cluster may alter autonomic regulation of BP, we sequenced ∼15 kilobase pairs in 15q24 containing their coding and 5′- and 3′-untranslated regions in 80 individuals. We identified 63 variants: 25 in coding regions of CHRNA3, CHRNA5, and CHRNB4 and 48 noncoding single-nucleotide polymorphisms (SNPs). Haplotype frequencies varied across ethnic populations. We assessed the contribution of six SNPs in the putative catestatin binding region of CHRNA3 and CHRNB4 to autonomic traits. In twins, catestatin and BP were heritable. CHRNA3 SNPs and haplotypes containing K95K (G285A) associated with circulating plasma catestatin, epinephrine levels, as well as systolic BP, suggesting altered coupling of the nAChRs to BP. Studies of chromaffin cells in vitro reveal that nicotinic agonist stimulation releases catecholamines and CHGA, a process augmented by overexpression of CHRNA3 and blocked by catestatin. These cellular events suggest a homeostatic mechanism underlying the pleiotropic actions of CHRNA3 genetic variation on autonomic function observed in twins.
45.	Söderström, T., et al. (author) Approaches for continuous-time modeling in errors-in-variables identification 2005 Reports (other academic/artistic)
46.	Söderström, Torsten, et al. (author) Using continuous-time modeling for errors-in-variables identification 2006 In: 14th IFAC Symposium on System Identification. Conference paper (peer-reviewed)
47.	Wen, Gen, et al. (author) Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. 2004 In: Am J Hum Genet. - 0002-9297. ; 74:2, s. 197-207 Journal article (other academic/artistic)
48.	Bhikkaji, B, et al. (author) A recursive algorithm for estimating parameters in a one dimensional diffusion system 2003 In: 13th IFAC Symposium on System Identification. Conference paper (peer-reviewed)
49.	Bhikkaji, B, et al. (author) Reduced order models for a two-dimensional heat diffusion system 2004 In: International Journal of Control. ; 77:18, s. 1532-1548 Journal article (peer-reviewed)
50.	Bhikkaji, B, et al. (author) Reduced order models for a two-dimensional heat diffusion system 2003 Reports (other academic/artistic)abstract In this paper, a two-dimensional heat diffusion system, which is modeled by a partial differential equation (PDE) is considered. Finite order approximations, for the infinite order PDE model, are constructed first by a direct application of the standard finite difference approximation (FD) scheme. Using tools of linear algebra, the constructed FD approximate models are reduced to computationally simpler models without any loss of accuracy. Further, the reduced approximate models are modified by replacing its poles with their respective asymptotic limits. Numerical experiments suggest that the proposed modifications improve the accuracy of the approximate models.

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