| 1. |
- Schwarz, E, et al.
(author)
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Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
- 2019
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In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1, s. 12-
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Journal article (peer-reviewed)abstract
- Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain magnetic resonance imaging (MRI) measures for diagnostic application, but this approach has been hampered by sample size limitations and lack of differential diagnostic data. Here, we performed a multi-site machine learning analysis to explore brain structural patterns of T1 MRI data in 2668 individuals with schizophrenia, bipolar disorder or attention-deficit/ hyperactivity disorder, and healthy controls. We found reproducible changes of structural parameters in schizophrenia that yielded a classification accuracy of up to 76% and provided discrimination from ADHD, through it lacked specificity against bipolar disorder. The observed changes largely indexed distributed grey matter alterations that could be represented through a combination of several global brain-structural parameters. This multi-site machine learning study identified a brain-structural signature that could reproducibly differentiate schizophrenia patients from controls, but lacked specificity against bipolar disorder. While this currently limits the clinical utility of the identified signature, the present study highlights that the underlying alterations index substantial global grey matter changes in psychotic disorders, reflecting the biological similarity of these conditions, and provide a roadmap for future exploration of brain structural alterations in psychiatric patients.
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| 2. |
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| 3. |
- Elvsashagen, T, et al.
(author)
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The genetic architecture of human brainstem structures and their involvement in common brain disorders
- 2020
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4016-
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Journal article (peer-reviewed)abstract
- Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
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| 4. |
- Malmqvist, Anna, et al.
(author)
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Increased peripheral levels of TARC/CCL17 in first episode psychosis patients
- 2019
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In: Schizophrenia Research. - : ELSEVIER. - 0920-9964 .- 1573-2509. ; 210, s. 221-227
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Journal article (peer-reviewed)abstract
- Background: Evidence for a link between the pathophysiology of schizophrenia and the immune system is mounting. Altered levels of chemokines in plasma have previously been reported in patients with schizophrenia under antipsychotic medication. Here we aimed to study both peripheral and central chemokine levels in drugnaive or short-time medicated first episode psychosis (FEP) patients. Method: We analyzed nine chemokines in plasma and CSF from 41 FEP patients and 22 healthy controls using electrochemiluminescence assay. Results: In plasma four chemokines; TARC/CCL17, eotaxin/CCL11, MDC/CCL22, IP-10/CXCL10 and in CSF one chemokine; IP-10/CXCL10 showed reliable detection in N50% of the cases. FEP patients displayed increased levels of TARC/CCL17 in plasma compared to healthy controls, 89.6 (IQR 66.2-125.8) pg/mL compared to 48.6 (IQR 28.0-71.7) pg/mL (p = 0.001). The difference was not attributed to confounding factors. Plasma TARC/CCL17 was not associated with PANSS, CGI or GAF scores, neither with cognitive functions. The chemokines eotaxin/CCL11, MDC/CCL22, IP-10/CXCL10 in plasma and IP-10/CXCL10 in CSF did not differ between FEP patients and controls. Conclusion: In line with a previous study showing that chronic patients with schizophrenia display increased plasma TARC/CCL17 levels, we here found an elevation in FEP patients suggesting a role of TARC/CCL17 in early stages of schizophrenia. The exactmechanism of this involvement is still unknown and future longitudinal studies as well as studies of central and peripheral chemokine levels would be of great interest. (C) 2018 Elsevier B.V. All rights reserved.
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| 5. |
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| 6. |
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| 7. |
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| 8. |
- Orhan, F., et al.
(author)
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Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis
- 2018
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In: Acta Psychiatrica Scandinavica. - : WILEY. - 0001-690X .- 1600-0447. ; 138:5, s. 432-440
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Journal article (peer-reviewed)abstract
- ObjectiveMethodAccumulating evidence implicates immune activation in the development of schizophrenia. Here, monocyte numbers, monocyte chemoattractant protein-1 (MCP-1) and chitinase-3-like protein 1 (YKL-40) were investigated in plasma and cerebrospinal fluid (CSF) in first-episode psychosis (FEP) patients. CSF and blood were sampled from 42 first-episode psychosis (FEP) patients and 22 healthy controls. The levels of YKL-40 and MCP-1 were measured using electrochemiluminescence assay, and blood monocytes were counted using an XN-9000-hematology analyzer. ResultsConclusionWe found higher plasma levels of MCP-1 and YKL-40 in FEP patients compared with healthy controls, a condition that was unrelated to antipsychotic and/or anxiolytic medication. This was combined with an increased number of blood monocytes and a borderline significant increase in YKL-40 levels in the CSF of tobacco-free FEP patients. Plasma or CSF chemokines or blood monocytes did not correlate with the severity of symptoms or the level of functioning. These data demonstrate activation of monocytes in FEP and strengthens the idea of an immune dysfunction of psychotic disorders. Further studies are required to perceive a role of YKL-40 and MCP-1 in the initiation and progression of schizophrenia.
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| 9. |
- Agewall, S, et al.
(author)
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Risk factors for myocardial infarction with normal coronary arteries and myocarditis compared with myocardial infarction with coronary artery stenosis
- 2012
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In: Angiology. - : SAGE Publications. - 1940-1574 .- 0003-3197. ; 63:7, s. 500-503
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Journal article (peer-reviewed)abstract
- The interest and awareness of myocardial infarction with normal coronary arteries (MINCA) have increased recently due to the frequent use of coronary angiography, the description of Takotsubo stress cardiomyopathy, and new sensitive troponin analyses. The prevalence of MINCA in all patients with myocardial infarction (MI) was registered during a 3-month period in the Stockholm metropolitan area in Sweden. The results showed that MINCA is more common than previously thought (7%) and affecting one third of every woman with MI. Patients with myocarditis were younger and more often presented with signs of inflammation such as elevated C-reactive protein and fever. Myocarditis constitutes an important differential diagnosis for coronary artery disease. There is a need for larger studies of MINCA, including investigation with cardiac magnetic resonance imaging, to establish prevalence and pathological process in this important subgroup of MI.
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| 10. |
- Collste, O., et al.
(author)
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Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging: results from the Stockholm Myocardial Infarction with Normal Coronaries study
- 2013
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In: Journal of Internal Medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 273:2, s. 189-196
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Journal article (peer-reviewed)abstract
- Collste O, Sorensson P, Frick M, Agewall S, Daniel M, Henareh L, Ekenback C, Eurenius L, Guiron C, Jernberg T, Hofman-Bang C, Malmqvist K, Nagy E, Arheden H, Tornvall P (Sodersjukhuset, Stockholm; Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden; University of Oslo, Oslo, Norway; Sankt Goran Hospital Capio, Karolinska Institutet, Stockholm; Huddinge, Stockholm; Danderyd Hospital, Karolinska Institutet, Stockholm; and Skane University Hospital, Lund University, Lund, Sweden). Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging: results from the Stockholm Myocardial Infarction with Normal Coronaries study. J Intern Med 2013; 273: 189-196. Objectives Myocardial infarction with angiographically normal coronary arteries (MINCA) is an important subtype of myocardial infarction; however, the prevalence, underlying pathophysiology, prognosis and optimal management of this condition are still largely unknown. Cardiovascular magnetic resonance (CMR) imaging has the potential to clarify the underlying pathology in patients with MINCA. The objective of this study was to investigate the diagnostic value of CMR imaging in this group of patients. Design The prospective, multicentre, observational Stockholm Myocardial Infarction with Normal Coronaries (SMINC) study. Setting Coronary care units in the Stockholm metropolitan area. Subjects Patients between 35 and 70 years of age with MINCA were consecutively included in the screening phase of the SMINC study. All patients had a typical clinical presentation, fulfilling the universal definition of myocardial infarction and had normal coronary angiography finding. Patients with known structural or coronary heart disease or other known causes of elevated troponin levels were excluded. Results In total, 176 patients with MINCA were screened from 2007 to 2011. Of these, 152 underwent CMR imaging. The investigation was performed a median of 12 (interquartile range 628) days after hospital admission; 67% of the findings were normal, whereas 19% of patients had signs of myocardial necrosis and 7% had signs of myocarditis. The remaining patients (7%) had either unrecognized hypertrophic cardiomyopathy or could not be classified. Conclusion In this consecutive series of patients with MINCA, CMR imaging may help to differentiate between those with myocarditis, myocardial necrosis and normal myocardium. The incidence of MINCA was higher than previously reported. After excluding cases of myocarditis, MINCA consists of a large group of patients with normal CMR imaging results and a smaller group with myocardial necrosis. The aetiologies of these different imaging findings need to be explored.
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| 11. |
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| 12. |
- Karlsson, J, et al.
(author)
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Beta1-adrenergic receptor gene polymorphisms and response to beta1-adrenergic receptor blockade in patients with essential hypertension
- 2004
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In: Clinical Cardiology. - 0160-9289 .- 1932-8737. ; 27:6 SUPPL. 3, s. 347-350
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Journal article (peer-reviewed)abstract
- Background: Studies suggest that the Ser49Gly and Arg389Gly polymorphisms in the β1-adrenergic receptor might be of functional importance for the cardiovascular system. Both have been associated with altered receptor activity in vitro, and with hypertension and cardiac failure in vivo. Hypothesis: The aim of this study was to test whether these polymorphisms were associated with the change in heart rate or blood pressure in patients with essential hypertension and left ventricular (LV) hypertrophy treated with the β1-adrenergic receptor blocker atenolol. Methods: Blood pressure and heart rate were measured in 101 hypertensive patients with echocardiographically verified LV hypertrophy, randomized in a double-blind study to treatment with either the β1-adrenergic receptor blocker atenolol or the angiotensin II type I receptor antagonist irbesartan. Changes in blood pressure and heart rate were evaluated after 12 weeks. Beta1-adrenergic receptor genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism. Results: We found no significant associations between the changes in the measured variables and either of the two polymorphisms. However, carriers of the 49Gly allele showed a tendency toward a greater reduction in heart rate compared with patients with the Ser/Ser49 genotype (p = 0.06). Conclusions: The Ser49Gly and Arg389Gly β1-adrenergic receptor polymorphisms do not seem to exert a major effect on the changes in heart rate and blood pressure during 12 weeks of treatment with atenolol in patients with essential hypertension and LV hypertrophy.
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| 13. |
- Kaufmann, Tobias, et al.
(author)
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Common brain disorders are associated with heritable patterns of apparent aging of the brain
- 2019
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In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 22:10, s. 1617-
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Journal article (peer-reviewed)abstract
- Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
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| 14. |
- Kristiansson, P., et al.
(author)
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Optical dot gain on newsprint determined with the Lund nuclear microprobe
- 1997
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In: Nuclear Instruments and Methods in Physics Research Section B. - Amsterdam : Elsevier. - 0168-583X .- 1872-9584. ; 130:1-4, s. 303-307
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Journal article (peer-reviewed)abstract
- A technique for measuring optical dot gain, i.e. the relative difference between the actual screen dot and the optically perceived one, is presented. By combining measurements from the non-optical nuclear microprobe with data from image analyzing technique the optical dot gain can be determined. The procedure to reach pixel by pixel correlation on a micrometer scale is discussed. In the newsprint sample studied in this investigation a typical optical dot gain between 15 and 20% was deduced. The variation in the optical dot gain was correlated with other characteristic parameters of the print and newsprint and especially a positive correlation to the mass density of the newsprint was observed. (C) 1997 Elsevier Science Ltd.
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| 15. |
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| 16. |
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| 17. |
- Malmqvist, L, et al.
(author)
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Liquid-target laser-plasma source for X-ray lithography
- 1997
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In: Microelectronic Engineering. - 1873-5568. ; 35:1-4, s. 535-536
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Journal article (peer-reviewed)abstract
- We describe a compact and practically debris-free laser-plasma x-ray source suitable for proximity lithography. The source is based on a microscopic fluorocarbon continuous liquid jet droplet target, generating high-brightness lambda=1.2-1.7 nm x-ray emission with similar to 5% conversion efficiency. This target type has the advantages of producing only negligible amounts of debris, and being regenerative, thereby allowing high-repetition-rate uninterrupted operation. The source is combined with an Au/SiNx x-ray mask to demonstrate lithography of sub-100 nm structures in SAL-601 chemically enhanced resist.
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| 18. |
- Malmqvist, L, et al.
(author)
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Nanometer table-top proximity x-ray lithography with liquid-target laser-plasma source
- 1997
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In: Journal of Vacuum Science and Technology B. - : American Vacuum Society. - 1520-8567. ; 15:4, s. 814-817
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Journal article (peer-reviewed)abstract
- A compact laser-plasma proximity x-ray lithography system suitable for laboratory-scale low-volume nanometer patterning is presented. The laser-plasma source, which is based on a fluorocarbon liquid-jet target, generates high-brightness lambda = 1.2-1.7 nm x-ray emission with only negligible debris production. The Au/SiNx x-ray mask is fabricated by employing ion milling and a high-contrast e-beam resist. With SAL-601 chemically enhanced resist we demonstrate fabrication of high-aspect-ratio, sub-100 nm structures. The exposure time is currently 20 min using a compact 10 Hz, lambda = 532 nm, 70 mJ/pulse mode-locked Nd:YAG laser. However, the regenerative liquid-jet target is designed for operation with future, e.g., 1000 Hz, lasers resulting in projected exposure times of similar to 10 s. (C) 1997 American Vacuum Society.
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| 19. |
- Verikas, Antanas, 1951-, et al.
(author)
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A New method for colour measurements in graphic arts
- 1999
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In: Color Research and Application. - New York : Wiley-Blackwell. - 0361-2317 .- 1520-6378. ; 24:3, s. 185-196
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Journal article (peer-reviewed)abstract
- This article presents a method for colour measurements directly on printed half-tone multicoloured pictures. The article introduces the concept of colour impression. By this concept we mean the CMY or CMYK vector (colour vector), which lives in the three- or four-dimensional space of printing inks. Two factors contribute to values of the vector components, namely, the percentage of the area covered by cyan, magenta, yellow, and black inks (tonal values) and ink densities. The colour vector expresses integrated information about the tonal values and ink densities. Values of the colour vector components increase if tonal values or ink densities rise and vice versa. If, for some primary colour, the ink density and tonal value do not change, the corresponding component of the colour vector remains constant. If some reference values of the colour vector components are set from a preprint, then, after an appropriate calibration, the colour vector directly shows how much the operator needs to raise or lower the cyan, magenta, yellow, and black ink densities in order to correct colours of the picture being measured. The values of the components are obtained by registering the RGB image from the measuring area and then transforming the set of registered RGB values to the triplet or quadruple of CMY or CMYK values, respectively. Algorithms based on artificial neural networks are used for performing the transformation. During the experimental investigations, we have found a good correlation between components of the colour vector and ink densities.
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| 20. |
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| 21. |
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| 22. |
- Ahlqvist, E., et al.
(author)
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Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
- 2018
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In: Lancet Diabetes & Endocrinology. - : Elsevier BV. - 2213-8587. ; 6:5, s. 361-369
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Journal article (peer-reviewed)abstract
- Background Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide a powerful tool to individualise treatment regimens and identify individuals with increased risk of complications at diagnosis. Methods We did data-driven cluster analysis (k-means and hierarchical clustering) in patients with newly diagnosed diabetes (n=8980) from the Swedish All New Diabetics in Scania cohort. Clusters were based on six variables (glutamate decarboxylase antibodies, age at diagnosis, BMI, HbA(1c), and homoeostatic model assessment 2 estimates of beta-cell function and insulin resistance), and were related to prospective data from patient records on development of complications and prescription of medication. Replication was done in three independent cohorts: the Scania Diabetes Registry (n=1466), All New Diabetics in Uppsala (n=844), and Diabetes Registry Vaasa (n=3485). Cox regression and logistic regression were used to compare time to medication, time to reaching the treatment goal, and risk of diabetic complications and genetic associations. Findings We identified five replicable clusters of patients with diabetes, which had significantly different patient characteristics and risk of diabetic complications. In particular, individuals in cluster 3 (most resistant to insulin) had significantly higher risk of diabetic kidney disease than individuals in clusters 4 and 5, but had been prescribed similar diabetes treatment. Cluster 2 (insulin deficient) had the highest risk of retinopathy. In support of the clustering, genetic associations in the clusters differed from those seen in traditional type 2 diabetes. Interpretation We stratified patients into five subgroups with differing disease progression and risk of diabetic complications. This new substratification might eventually help to tailor and target early treatment to patients who would benefit most, thereby representing a first step towards precision medicine in diabetes.
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| 23. |
- Alnaes, Dag, et al.
(author)
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Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
- 2019
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In: JAMA psychiatry. - : AMER MEDICAL ASSOC. - 2168-6238 .- 2168-622X. ; 76:7, s. 739-748
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Journal article (peer-reviewed)abstract
- ImportanceBetween-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature. ObjectivesTo compare brain structural variability between individuals with schizophrenia and healthy controls and to test whether respective variability reflects the polygenic risk score (PRS) for schizophrenia in an independent sample of healthy controls. Design, Setting, and ParticipantsThis case-control and polygenic risk analysis compared MRI-derived cortical thickness and subcortical volumes between healthy controls and patients with schizophrenia across 16 cohorts and tested for associations between PRS and MRI features in a control cohort from the UK Biobank. Data were collected from October 27, 2004, through April 12, 2018, and analyzed from December 3, 2017, through August 1, 2018. Main Outcomes and MeasuresMean and dispersion parameters were estimated using double generalized linear models. Vertex-wise analysis was used to assess cortical thickness, and regions-of-interest analyses were used to assess total cortical volume, total surface area, and white matter, subcortical, and hippocampal subfield volumes. Follow-up analyses included within-sample analysis, test of robustness of the PRS threshold, population covariates, outlier removal, and control for image quality. ResultsA comparison of 1151 patients with schizophrenia (mean [SD] age,33.8[10.6] years; 68.6% male [n=790] and 31.4% female [n=361]) with 2010 healthy controls (mean [SD] age,32.6[10.4] years; 56.0% male [n=1126] and 44.0% female [n=884]) revealed higher heterogeneity in schizophrenia for cortical thickness and area (t = 3.34), cortical (t=3.24) and ventricle (t range, 3.15-5.78) volumes, and hippocampal subfields (t range, 2.32-3.55). In the UK Biobank sample of 12 490 participants (mean [SD] age,55.9 [7.5] years; 48.2% male [n=6025] and 51.8% female [n=6465]), higher PRS was associated with thinner frontal and temporal cortices and smaller left CA2/3 (t=-3.00) but was not significantly associated with dispersion. Conclusions and RelevanceThis study suggests that schizophrenia is associated with substantial brain structural heterogeneity beyond the mean differences. These findings may reflect higher sensitivity to environmental and genetic perturbations in patients, supporting the heterogeneous nature of schizophrenia. A higher PRS was associated with thinner frontotemporal cortices and smaller hippocampal subfield volume, but not heterogeneity. This finding suggests that brain variability in schizophrenia results from interactions between environmental and genetic factors that are not captured by the PRS. Factors contributing to heterogeneity in frontotemporal cortices and hippocampus are key to furthering our understanding of how genetic and environmental factors shape brain biology in schizophrenia.
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| 24. |
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| 25. |
- Bokinge, Mattias, 1984, et al.
(author)
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A Method to Identify Risks Associated with a PLM Solution
- 2012
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In: IFIP Advances in Information and Communication Technology. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1868-4238 .- 1868-422X.
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Conference paper (peer-reviewed)abstract
- Not all investments in PLM (Product Lifecycle Management) are successful. Measuring the business effects of a PLM solution is essential, but can only be applied subsequent to solution deployment. It could be more powerful to make an early evaluation of the PLM solution, resulting in the business benefits, making corrections possible prior to deployment.In this paper, a method to identify risks associated with a PLM solution is proposed based on an architecture model of a PLM solution and available PLM solution guidelines. Its use is demonstrated in an industry case and evaluated as compared to its intended use. The intention is that identified risks can help identify change proposals to the PLM solution or to obtain a better understanding of the consequences for solution deployment.The findings indicate that the method is a useful support for identifying risks associated with a PLM solution. However, additional testing of the method in real settings is necessary to strengthen that indication.
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| 26. |
- Brink, Rob C., et al.
(author)
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Anterior Spinal Overgrowth Is the Result of the Scoliotic Mechanism and Is Located in the Disc
- 2017
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In: Spine. - : LIPPINCOTT WILLIAMS & WILKINS. - 0362-2436 .- 1528-1159. ; 42:11, s. 818-822
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Journal article (peer-reviewed)abstract
- Study Design. Cross-sectional study. Objective. To investigate the presence and magnitude of anterior spinal overgrowth in neuromuscular scoliosis and compare this with the same measurements in idiopathic scoliosis and healthy spines. Summary of Background Data. Anterior spinal overgrowth has been described as a potential driver for the onset and progression of adolescent idiopathic scoliosis (AIS). Whether this anterior overgrowth is specific for AIS or also present in nonidiopathic scoliosis has not been reported. Methods. Supine computed tomography (CT) scans of thirty AIS patients (thoracic Cobb 21-81 degrees), thirty neuromuscular (NM) scoliotic patients (thoracic Cobb 19-101 degrees) and 30 nonscoliotic controls were used. The difference in length in per cents between the anterior and posterior side {[(Delta A-P)/P] * 100%, abbreviated to A-P%} of each vertebral body and intervertebral disc, and between the anterior side of the spine and the spinal canal (A-C%) were determined. Results. The A-P% of the thoracic curves did not differ between the AIS (+1.2 perpendicular to 2.2%) and NM patients (+0.9 +/- 4.1%, P = 0.663), both did differ, however, from the same measurements in controls (-3.0 +/- 1.6%; Pamp;lt; 0.001) and correlated linearly with the Cobb angle (AIS r = 0.678, NM r = 0.687). Additional anterior length was caused by anterior elongation of the discs (AIS: A-P% disc +17.5 +/- 12.7% vs. A-P% body - 2.5 +/- 2.6%; Pamp;lt; 0.001, NM: A-P% disc + 19.1 +/- 18.0% vs. A-P% body -3.5 +/- 5.1%; Pamp;lt; 0.001). The A-C% T1-S1 in AIS and NM patients were similar (+ 7.9 +/- 1.8% and + 8.7 +/- 4.0%, P = 0.273), but differed from the controls (+4.2 +/- 3.3%; Pamp;lt; 0.001). Conclusion. So called anterior overgrowth has been postulated as a possible cause for idiopathic scoliosis, but apparently it occurs in scoliosis with a known origin as well. This suggests that it is part of a more generalized scoliotic mechanism, rather than its cause. The fact that the intervertebral discs contribute more to this increased anterior length than the vertebral bodies suggests an adaptation to altered loading, rather than a primary growth disturbance.
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| 27. |
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| 28. |
- Carlsson, J., et al.
(author)
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Application of optical fluorescence spectroscopy to paper production
- 1999
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In: TAPPI INTERNATIONAL PAPER PHYSICS CONFERENCE. - Atlanta : Tappi Press. - 0898529549 ; , s. 429-436
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Conference paper (peer-reviewed)abstract
- Fluorescence light emitted from paper following the absorption of either ultraviolet or visible light has a wavelength distribution determined by the chemical composition of the paper. This can be used both for laboratory measurements of paper characteristics and for on-line monitoring of the paper during production. Such measurements can be performed non-intrusively at sampling rates high enough to give a sub-millimetre resolution in the machine direction in a paper machine or rerewinder. In this project two types of fluorescence monitors have been constructed. They are operating at different wavelengths and thereby they monitor different substances in the paper. The monitors have been tested at newsprint producing paper mills together with an optical speedometer. The measurements in the production environment have shown that the equipment is capable of indirectly monitoring paper quality parameters which affect the local abundance of lignin. Examples of such parameters are the number of shives in the paper and wire marks. A fluorescence based method for scanning cross-directional newsprint profiles in the laboratory has been developed. From these measurements the relative shrinkage of the paper during drying can be calculated using time-frequency analysis.
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| 29. |
- Carlsson, J, et al.
(author)
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Strategy for boron neutron capture therapy against tumor cells with over-expression of the epidermal growth factor-receptor.
- 1994
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In: International Journal of Radiation Oncology, Biology, Physics. - 0360-3016 .- 1879-355X. ; 30:1, s. 105-15
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Journal article (peer-reviewed)abstract
- PURPOSE: Gliomas, squamous carcinomas and different adenocarcinomas from breast, colon and prostate might have an increased number of epidermal growth factor (EGF) receptors. The receptors are, in these cases, candidates for binding of receptor specific toxic conjugates that might inactivate cellular proliferation. The purpose of this study was to evaluate whether it is reasonable to try ligand-dextran based conjugates for therapy.METHODS AND MATERIALS: EGF or TGF alpha were conjugated to dextran and binding, internalization, retention and degradation of eight types of such conjugates were analyzed in EGF-receptor amplified glioma cells. The conjugates were labelled with radioactive nuclides to allow detection and two of the conjugates were carrying boron in the form of carboranyl amino acids or aminoalkyl-carboranes. Comparative binding tests, applying 125I-EGF, were made with cultured breast, colon and prostate adenocarcinoma, glioma and squamous carcinoma cells. Some introductory tests to label with 76Br for positron emission tomography and with 131I for radionuclide therapy were also made.RESULTS: The dextran part of the conjugates did not prevent receptor specific binding. The amount of receptor specific binding varied between the different types of conjugates and between the tested cell types. The dextran part improved intracellular retention and radioactive nuclides were retained for at least 20-24 h. The therapeutical effect improved when 131I was attached to EGF-dextran instead of native EGF.CONCLUSION: The improved cellular retention of the ligand-dextran conjugates is an important property since it gives extended exposure time when radionuclides are applied and flexibility in the choice of time for application of neutrons in boron neutron capture therapy (BNCT). It is possible that ligand-dextran mediated BNCT might allow, if the applied neutron fields covers rather wide areas around the primary tumor, locally spread cells that otherwise would escape treatment to be inactivated.
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| 30. |
- Carlsson, J, et al.
(author)
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Time-resolved Studies of Light-propagation In Paper
- 1995
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In: Applied Optics. - 2155-3165. ; 34:9, s. 1528-1535
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Journal article (peer-reviewed)abstract
- A method for time-resolved recording of light scattering in thin, highly scattering media is described. Subpicosecond pulses from a high-power Ti:sapphire laser are used, and single-shot recordings of the scattered light are made with a fast streak camera. The method is applied to the study of light scattering in paper, and a 1-ps resolution is demonstrated. The dependence of the light scattering on the basis of weight and density of the paper has been studied. A white-light continuum generated from the high-power pulses by the use of self phase modulation in water is used to study the wavelength dependence of the scattering process. A model for the propagation of light in paper has been developed and used in Monte Carlo simulations. The experimental results are used for testing this model, and absorption and scattering parameters are determined from that comparison.
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| 31. |
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| 32. |
- Daniel, M., et al.
(author)
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Prevalence of Anxiety and Depression Symptoms in Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries
- 2018
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In: American Journal of Medicine. - : Elsevier BV. - 0002-9343 .- 1555-7162. ; 131:9, s. 1118-1124
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Journal article (peer-reviewed)abstract
- BACKGROUND: Myocardial infarction with non-obstructive coronary arteries is a working diagnosis for several heart disorders. Previous studies on anxiety and depression in patients with myocardial infarction with non-obstructive coronary arteries are lacking. Our aim was to investigate the prevalence of anxiety and depression among patients with myocardial infarction with non-obstructive coronary arteries. METHODS: We included 99 patients with myocardial infarction with non-obstructive coronary arteries together with age- and sex-matched control groups who completed the Beck Depression Inventory and the Hospital Anxiety and Depression Scale (HADS) 3 months after the acute event. RESULTS: Using the Beck Depression Inventory, we found that the prevalence of depression in patients with myocardial infarction with non-obstructive coronary arteries (35%) was higher than in healthy controls (9%; P = .006) and similar to that of patients with coronary heart disease (30%; P = .954). Using the HADS anxiety subscale, we found that the prevalence of anxiety in patients with myocardial infarction with non-obstructive coronary arteries (27%) was higher than in healthy controls (9%; P = .002) and similar to that of patients with coronary heart disease (21%; P = .409). Using the HADS depression subscale, we found that the prevalence of depression in patients with myocardial infarction with non-obstructive coronary arteries (17%) was higher than in healthy controls (4%; P = .003) and similar to that of patients with coronary heart disease (13%; P = .466). Patients with myocardial infarction with non-obstructive coronary arteries and takotsubo syndrome scored higher on the HADS anxiety subscale than those without (P = .028). CONCLUSIONS: This is the first study on the mental health of patients with myocardial infarction with non obstructive coronary arteries to show that prevalence rates of anxiety and depression are similar to those in patients with coronary heart disease. (C) 2018 Elsevier Inc. All rights reserved.
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| 34. |
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| 35. |
- Gagliardi, L, et al.
(author)
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Theoretical study of the lowest B-1(U) states of trans-stilbene
- 2002
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In: The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory. - : American Chemical Society (ACS). - 1520-5215. ; 106:32, s. 7355-7361
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Journal article (peer-reviewed)abstract
- The results of a theoretical study of the ground state, 1(1)A(g), and of the lowest B-1(u) states of trans-stilbene are presented. The vertical and adiabatic excitation energies of the lowest B-1(u) states have been computed using multiconfigurational SCF theory, followed by second-order perturbation. theory. It is shown that the two lowest excited states are separated by a small energy gap in the Franck-Condon region. They are the 1(1)B(u), characterized by the HOMO-->LUMO single excitation substantially localized on the ethylenic moiety, and the 2(1)B(u), formed by a combination,of one electron excitations localized mainly on the benzene rings. The most intense transition is found to be the lowest in energy when the interaction between different states is included at the level of second-order perturbation theory. The vibronic structure of emission and absorption spectra of the two lowest B-1(u) states have been determined within the Franck-Condon approximation. The spectrum calculated for the 1(1)B(u) state agrees with the experimental spectrum, while the low intensity band computed for the 2(1)B(u) state has no experimental counterpart. It is concluded that this band is buried in the strong 1(1)B(u) absorption and therefore not observed.
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| 36. |
- Guldris Leon, Lorena, 1983, et al.
(author)
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Evaluation of Refractory Metal Concentrations in Nano-Particulate Pressed-Powder Pellets Using LA-ICP-MS
- 2022
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In: Minerals. - : MDPI AG. - 2075-163X. ; 12:7
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Journal article (peer-reviewed)abstract
- Whole-rock geochemical analysis is a standard method to measure the chemical composition of ores. Analysis of refractory ore metals such as Ta and W typically requires fused bead and acid digestion followed by inductively coupled plasma atomic emission spectrometry (ICP-AES) and inductively coupled mass spectrometry (ICP-MS). Since these techniques are time-consuming and expensive, there is a demand for methods that can quantitatively measure low elemental concentration of refractory ore metals using a less expensive and simple approach. This paper evaluates preparation and analytical procedures developed to obtain whole-rock element concentrations of ore samples and mineral concentrates. It shows that the production of nano-particulate pressed-powder pellets followed by LA-ICP-MS analysis of W and Ta ores can be used to determine, within the error margin, the concentrations of the refractory metals W, Ta, Nb, and Sn compared to a reference values obtained by solution analysis. The results have implications for developing a commercially viable method for analysis of refractory elements to benefit mineral processing given the simplicity and resource-efficiency of the combined pressed pellet production and laser ablation analytical methodology.
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| 37. |
- Hagfeldt, A., et al.
(author)
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A system approach to molecular solar cells
- 2004
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In: Coordination chemistry reviews. - : Elsevier BV. - 0010-8545 .- 1873-3840. ; 248:13-14, s. 1501-1509
-
Research review (peer-reviewed)abstract
- This paper gives an overview of the research and development of dye-sensitized solar cells (DSC) within the Swedish research program 'Angstrom Solar Center'. A path towards low production cost is the development of a continuous process, which allows the production of solar cells in large volumes and with a high productivity. We have developed a deposition method for the production of the mesoporous TiO2, electrode layer that is based on compression of a powder film at room temperature. This technique allows us to use flexible substrates-a prerequisite fora continuous process. A novel interconnect technology, compatible with a continuous production process, is described. Stability data of plastic DSC, exposed to indoor light for more than 10,000 h, demonstrates the possibility for the technology to be explored for various types of indoor applications. Optimization of the DSC is a challenging task as it is a complex highly interacting molecular system. A system approach is proposed, where the complete DSC is investigated with a series of measurement techniques ('toolbox') that allows the study of the internal processes under relevant conditions. Two examples of such techniques are given.
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| 38. |
- Hardell, L, et al.
(author)
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Testicular cancer and occupational exposure to polyvinyl chloride plastics: A case-control study
- 2004
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 109:3, s. 425-429
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Journal article (peer-reviewed)abstract
- Exposure to polyvinyl chloride. (PVC) plastics as a risk factor for testicular cancer was investigated. In total, 981 cases who were 20-75 years old and had reported to the Swedish Cancer Registry during 1993-1997 were included. One matched control from the population registry was used. Exposure was assessed by a questionnaire that was supplemented over the phone. Furthermore, an occupational hygienist qualified all exposures. In all, 791 matched pairs completed the questionnaire. Overall exposure to PVC plastics gave the odds ratio (OR)= 1.35, 95% confidence interval (Cl)= 1.06-1.71, increasing with > 10 year latency period to OR= 1.45, 95% Cl = 1.06-1.98. No dose-response relationships were found but rather an inverse relationship with the highest odds ratios in the lowest exposure category. In conclusion, no clear association with testicular cancer and exposure to PVC could be found in our study in contrast to a previous observation.
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| 39. |
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| 40. |
- Hertz, H.M, et al.
(author)
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Optically trapped non-linear particles as probes for scanning near-field optical microscopy
- 1995
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In: Ultramicroscopy. - 0304-3991. ; 57:2-3, s. 309-312
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Journal article (peer-reviewed)abstract
- We use the frequency doubled light from an optically trapped lithium niobate particle for non-intrusive scanning near-field optical microscopy. The detected power from this 50-100 nm diameter probe is currently tens of pW and is expected to approach nW with an improved detection system. The current experimental resolution is approximately 0.5 [mu]m, while the ultimate theoretical resolution is 70-90 nm. An acoustic trap which potentially allows higher resolution imaging is briefly described.
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| 41. |
- Högfeldt, Anna-Karin, et al.
(author)
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Program Leadership from a Nordic Perspective
- 2012
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In: Proceedings of the 8th International CDIO Conference, Queensland University of Technology, Brisbane..
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Conference paper (peer-reviewed)
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- Levandowski, Christoffer E, 1984, et al.
(author)
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PLM as Support for Global Design Reuse - Long Term Benefits and Immediate Drawbacks
- 2012
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In: IFIP Advances in Information and Communication Technology. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1868-4238 .- 1868-422X.
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Conference paper (peer-reviewed)abstract
- To stay competitive, a large company must make use of its size and gain economy of scale, one way being through reusing designed parts and tech-nology knowledge globally throughout the organization.This paper describes a case study performed at a company that is implement-ing a new Product Lifecycle Management (PLM) system, globally across sever-al different divisions, to be able to reuse design across the organization.The study shows that though global design reuse is the final goal, the way there is long. The true benefits are still in the future, but there are issues with the PLM solution on the designer level. To prevent such a situation in the fu-ture, the authors suggest that benefits shall be defined for all phases in the PLM implementation, not just as high business goals for the final stage. That way, you keep momentum in the change effort and keep all parties motivated.
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| 47. |
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| 50. |
- Malmqvist, K. G., et al.
(author)
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PIXE and proton microprobe advances at the Lund Institute of Technology
- 1989
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In: Nuclear Inst. and Methods in Physics Research, B. - 0168-583X. ; 40-41:PART 1, s. 685-689
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Journal article (peer-reviewed)abstract
- A review of recent advances in high-energy ion beam analysis at the Lund Institute of Technology is presented. A nonvacuum specimen chamber allows chemical speciation using a combination of ion beam analysis and controlled heating. The development of a new versatile scanning proton microbeam based on a new dedicated accelerator, an achromatic triplet lens and an advanced specimen chamber is outlined together with the performance of a microVAX-II/VMEbus-based data acquisition system.
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