| 1. |
- Sliz, E., et al.
(författare)
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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- 2023
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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| 2. |
- Tabassum, R, et al.
(författare)
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Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
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Tidskriftsartikel (refereegranskat)abstract
- Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
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| 3. |
- Hackman, T., et al.
(författare)
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Spot activity of II Peg
- 2011
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Ingår i: Astronomical Notes - Astronomische Nachrichten. - : Wiley. - 0004-6337 .- 1521-3994. ; 332:9-10, s. 859-865
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Tidskriftsartikel (refereegranskat)abstract
- We have studied the long-term spot activity of the RS CVn star II Peg by means of Doppler imaging based on spectroscopy and time series analysis of photometry. We present 28 Doppler imaging temperature maps spanning the years 1994-2010, of which 14 were calculated for the present study. The longitudinal spot distribution, derived from the surface temperature maps, is compared with epochs of the light curve minima, derived from photometric observations. We detect a longitudinal drift in the major spot structure during 1995-2003. After this there is a clear decrease in the activity level and no clear drift can be seen. We conclude that the variations could be caused by a cyclic behaviour of the underlying magnetic dynamo.
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| 4. |
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| 5. |
- Snellman, J. E., et al.
(författare)
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Verification of Reynolds stress parameterizations from simulations
- 2012
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Ingår i: Astronomical Notes - Astronomische Nachrichten. - : Wiley. - 0004-6337 .- 1521-3994. ; 333:1, s. 78-83
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Tidskriftsartikel (refereegranskat)abstract
- We determine the timescales associated with turbulent decay and isotropization in closure models using anisotropically forced and freely decaying turbulence simulations and study the applicability of these models. We compare the results from anisotropically forced three-dimensional numerical simulations with the predictions of the closure models and obtain the turbulent timescales mentioned above as functions of the Reynolds number. In a second set of simulations, turning the forcing off enables us to study the validity of the closures in freely decaying turbulence. Both types of experiments suggest that the timescale of turbulent decay converges to a constant value at higher Reynolds numbers. Furthermore, the relative importance of isotropization is found to be about 2.5 times larger at higher Reynolds numbers than in the more viscous regime.
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| 6. |
- Vaisala, M. S., et al.
(författare)
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Quantifying the effect of turbulent magnetic diffusion on the growth rate of the magneto-rotational instability
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 567
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Tidskriftsartikel (refereegranskat)abstract
- Context. In astrophysics, turbulent diffusion is often used in place of microphysical diffusion to avoid resolving the small scales. However, we expect this approach to break down when time and length scales of the turbulence become comparable with other relevant time and length scales in the system. Turbulent diffusion has previously been applied to the magneto-rotational instability (MRI), but no quantitative comparison of growth rates at different turbulent intensities has been performed. Aims. We investigate to what extent turbulent diffusion can be used to model the effects of small-scale turbulence on the kinematic growth rates of the MRI, and how this depends on angular velocity and magnetic field strength. Methods. We use direct numerical simulations in three-dimensional shearing boxes with periodic boundary conditions in the spanwise direction and additional random plane-wave volume forcing to drive a turbulent flow at a given length scale. We estimate the turbulent diffusivity using a mixing length formula and compare with results obtained with the test-field method. Results. It turns out that the concept of turbulent diffusion is remarkably accurate in describing the effect of turbulence on the growth rate of the MRI. No noticeable breakdown of turbulent diffusion has been found, even when time and length scales of the turbulence become comparable with those imposed by the MRI itself. On the other hand, quenching of turbulent magnetic diffusivity by the magnetic field is found to be absent. Conclusions. Turbulence reduces the growth rate of the MRI in the same way as microphysical magnetic diffusion does.
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| 7. |
- Brandenburg, Axel, et al.
(författare)
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NEW SCALING FOR THE ALPHA EFFECT IN SLOWLY ROTATING TURBULENCE
- 2013
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 762:2
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Tidskriftsartikel (refereegranskat)abstract
- Using simulations of slowly rotating stratified turbulence, we show that the alpha effect responsible for the generation of astrophysical magnetic fields is proportional to the logarithmic gradient of kinetic energy density rather than that of momentum, as was previously thought. This result is in agreement with a new analytic theory developed in this paper for large Reynolds numbers and slow rotation. Thus, the contribution of density stratification is less important than that of turbulent velocity. The a effect and other turbulent transport coefficients are determined by means of the test-field method. In addition to forced turbulence, we also investigate supernova-driven turbulence and stellar convection. In some cases (intermediate rotation rate for forced turbulence, convection with intermediate temperature stratification, and supernova-driven turbulence), we find that the contribution of density stratification might be even less important than suggested by the analytic theory.
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| 8. |
- Hackman, T., et al.
(författare)
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Doppler images of II Pegasi for 2004-2010
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 538, s. A126-
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We study the spot activity of II Peg during the years 2004-2010 to determine long- and short-term changes in the magnetic activity. In a previous study, we detected a persistent active longitude, as well as major changes in the spot configuration occurring on a timescale of shorter than a year. The main objective of this study is to determine whether the same phenomena persist in the star during these six years of spectroscopic monitoring. Methods. The observations were collected with the high-resolution SOFIN spectrograph at the Nordic Optical Telescope. The temperature maps were calculated using a Doppler imaging code based on Tikhonov regularization. Results. We present 12 new temperature maps that show spots distributed mainly over high and intermediate latitudes. In each image, 1-3 main active regions can be identified. The activity level of the star is clearly lower than during our previous study for the years 1994-2002. In contrast to the previous observations, we detect no clear drift of the active regions with respect to the rotation of the star. Conclusions. Having shown a systematic longitudinal drift of the spot-generating mechanism during 1994-2002, the star has clearly switched to a low-activity state for 2004-2010, during which the spot locations appear more random over phase space. It could be that the star is near to a minimum of its activity cycle.
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| 9. |
- Käpylä, Petri J., et al.
(författare)
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Flux concentrations in turbulent convection
- 2012
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Ingår i: Proceedings of the International Astronomical Union. - : Cambridge University Press. - 9781107033832 ; , s. 283-288
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Konferensbidrag (refereegranskat)abstract
- We present preliminary results from high resolution magneto-convection simulations where we find the formation of flux concentrations from an initially uniform magnetic field. The structures appear in roughly ten convective turnover times and live close to a turbulent diffusion time. The time scales are compatible with the negative effective magnetic pressure instability (NEMPI), although structure formation is not restricted to regions where the effective magnetic pressure is negative.
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| 10. |
- Käpylä, Petri J., et al.
(författare)
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Oscillatory large-scale dynamos from Cartesian convection simulations
- 2013
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Ingår i: Geophysical and Astrophysical Fluid Dynamics. - : Informa UK Limited. - 0309-1929 .- 1029-0419. ; 107:1-2, s. 244-257
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Tidskriftsartikel (refereegranskat)abstract
- We present results from compressible Cartesian convection simulations with and without imposed shear. In the former case the dynamo is expected to be of 2 type, which is generally expected to be relevant for the Sun, whereas the latter case refers to 2 dynamos that are more likely to occur in more rapidly rotating stars whose differential rotation is small. We perform a parameter study where the shear flow and the rotational influence are varied to probe the relative importance of both types of dynamos. Oscillatory solutions are preferred both in the kinematic and saturated regimes when the negative ratio of shear to rotation rates, qS/, is between 1.5 and 2, i.e. when shear and rotation are of comparable strengths. Other regions of oscillatory solutions are found with small values of q, i.e. when shear is weak in comparison to rotation, and in the regime of large negative qs, when shear is very strong in comparison to rotation. However, exceptions to these rules also appear so that for a given ratio of shear to rotation, solutions are non-oscillatory for small and large shear, but oscillatory in the intermediate range. Changing the boundary conditions from vertical field to perfect conductor ones changes the dynamo mode from oscillatory to quasi-steady. Furthermore, in many cases an oscillatory solution exists only in the kinematic regime whereas in the nonlinear stage the mean fields are stationary. However, the cases with rotation and no shear are always oscillatory in the parameter range studied here and the dynamo mode does not depend on the magnetic boundary conditions. The strengths of total and large-scale components of the magnetic field in the saturated state, however, are sensitive to the chosen boundary conditions.
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| 11. |
- Käpylä, P. J., et al.
(författare)
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Reynolds stress and heat flux in spherical shell convection
- 2011
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 531
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Tidskriftsartikel (refereegranskat)abstract
- Context. Turbulent fluxes of angular momentum and enthalpy or heat due to rotationally affected convection play a key role in determining differential rotation of stars. Their dependence on latitude and depth has been determined in the past from convection simulations in Cartesian or spherical simulations. Here we perform a systematic comparison between the two geometries as a function of the rotation rate. Aims. Here we want to extend the earlier studies by using spherical wedges to obtain turbulent angular momentum and heat transport as functions of the rotation rate from stratified convection. We compare results from spherical and Cartesian models in the same parameter regime in order to study whether restricted geometry introduces artefacts into the results. In particular, we want to clarify whether the sharp equatorial profile of the horizontal Reynolds stress found in earlier Cartesian models is also reproduced in spherical geometry. Methods. We employ direct numerical simulations of turbulent convection in spherical and Cartesian geometries. In order to alleviate the computational cost in the spherical runs, and to reach as high spatial resolution as possible, we model only parts of the latitude and longitude. The rotational influence, measured by the Coriolis number or inverse Rossby number, is varied from zero to roughly seven, which is the regime that is likely to be realised in the solar convection zone. Cartesian simulations are performed in overlapping parameter regimes. Results. For slow rotation we find that the radial and latitudinal turbulent angular momentum fluxes are directed inward and equatorward, respectively. In the rapid rotation regime the radial flux changes sign in accordance with earlier numerical results, but in contradiction with theory. The latitudinal flux remains mostly equatorward and develops a maximum close to the equator. In Cartesian simulations this peak can be explained by the strong banana cells. Their effect in the spherical case does not appear to be as large. The latitudinal heat flux is mostly equatorward for slow rotation but changes sign for rapid rotation. Longitudinal heat flux is always in the retrograde direction. The rotation profiles vary from anti-solar (slow equator) for slow and intermediate rotation to solar-like (fast equator) for rapid rotation. The solar-like profiles are dominated by the Taylor-Proudman balance.
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| 12. |
- Lindborg, M., et al.
(författare)
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Doppler images of DI Piscium during 2004-2006
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 562, s. A139-
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Tidskriftsartikel (refereegranskat)abstract
- Aims. DI Psc (HD 217352) is a Li-rich, rapidly rotating single K giant. We set out to study the spot configuration and activity level by calculating surface temperature maps of the star. Methods. We apply the Doppler imaging method on high-resolution optical spectroscopy obtained during 2004-2006. Results. In July-August 2004, no clear spot structures were visible, but the spot coverage increased in July 2005, and cool spots emerged, especially at intermediate latitudes. Later on in September 2006, the spot coverage increased and cool spots were visible on both sides of the equator. However, the map of 2006 suffers from bad phase coverage, meaning it is not possible to draw definite conclusions on the spot locations during that season. Conclusions. Compared with earlier Doppler maps of DI Psc and temperature maps obtained for other late-type stars with similar rotation rates, DI Psc seems to be in a low activity state especially during the observing season of July-August 2004. During the 2005 and 2006 observing seasons, the spot activity seen in the spectral line profiles and inferred from Doppler images increases, and the temperature contrast in our last map is more comparable to what was reported in an earlier study. Therefore, it can be concluded that the spot activity level of the star is variable over time. However, the present and previous Doppler images form too short a time series to draw conclusions about a possible activity cycle in DI Psc.
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| 13. |
- Mantere, M. J., et al.
(författare)
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Role of longitudinal activity complexes for solar and stellar dynamos
- 2012
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Ingår i: Proc. Int. Astron. Union. - 9781107033832 ; , s. 175-186
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Konferensbidrag (refereegranskat)abstract
- In this paper we first discuss observational evidence of longitudinal concentrations of magnetic activity in the Sun and rapidly rotating late-type stars with outer convective envelopes. Scenarios arising from the idea of rotationally influenced anisotropic convective turbulence being the key physical process generating these structures are then presented and discussed - such effects include the turbulent dynamo mechanism, negative effective magnetic pressure instability (NEMPI) and hydrodynamical vortex instability. Finally, we discuss non-axisymmetric stellar mean-field dynamo models, the results obtained with them, and compare those with the observational information gathered up so far. We also present results from a pure α2 mean-field dynamo model, which show that time-dependent behavior of the dynamo solutions can occur both in the form of an azimuthal dynamo wave and/or oscillatory behavior related to the alternating energy levels of the active longitudes.
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| 14. |
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| 15. |
- Kochukhov, Oleg, et al.
(författare)
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Magnetic field topology of the RS CVn star II Pegasi
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 550, s. A84-
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Tidskriftsartikel (refereegranskat)abstract
- Context. The dynamo processes in cool active stars generate complex magnetic fields responsible for prominent surface stellar activity and variability at different time scales. For a small number of cool stars magnetic field topologies were reconstructed from the time series of spectropolarimetric observations using the Zeeman Doppler imaging (ZDI) method, often yielding surprising and controversial results. Aims. In this study we follow a long-term evolution of the magnetic field topology of the RS CVn binary star II Peg using a more self-consistent and physically more meaningful modelling approach compared to previous ZDI studies. Methods. We collected high-resolution circular polarisation observations of II Peg using the SOFIN spectropolarimeter at the Nordic Optical Telescope. These data cover 12 epochs spread over 7 years, comprising one of the most comprehensive spectropolarimetric data sets acquired for a cool active star. A multi-line diagnostic technique in combination with a new ZDI code is applied to interpret these observations. Results. We have succeeded in detecting clear magnetic field signatures in average Stokes V profiles for all 12 data sets. These profiles typically have complex shapes and amplitudes of similar to 10(-3) of the unpolarised continuum, corresponding to mean longitudinal fields of 50-100 G. Magnetic inversions using these data reveals evolving magnetic fields with typical local strengths of 0.5-1.0 kG and complex topologies. Despite using a self-consistent magnetic and temperature mapping technique, we do not find a clear correlation between magnetic and temperature features in the ZDI maps. Neither do we confirm the presence of persistent azimuthal field rings found in other RS CVn stars. Reconstruction of the magnetic field topology of II Peg reveals significant evolution of both the surface magnetic field structure and the extended magnetospheric field geometry on the time scale covered by our observations. From 2004 to 2010 the total field energy drastically declined and the field became less axisymmetric. This also coincided with the transition from predominantly poloidal to mainly toroidal field topology. Conclusions. A qualitative comparison of the ZDI maps of II Peg with the prediction of dynamo theory suggests that the magnetic field in this star is produced mainly by the turbulent alpha(2) dynamo rather than the solar alpha Omega dynamo. Our results do not show a clear active longitude system, nor is there evidence of the presence of an azimuthal dynamo wave.
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| 16. |
- Suvitaival, T., et al.
(författare)
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Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis
- 2016
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Ingår i: Translational Psychiatry. - London. United Kingdom : Nature Publishing Group. - 2158-3188. ; 6:11
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Tidskriftsartikel (refereegranskat)abstract
- Psychotic patients are at high risk for developing obesity, metabolic syndrome and type 2 diabetes. These metabolic co-morbidities are hypothesized to be related to both treatment side effects as well as to metabolic changes occurring during the psychosis. Earlier metabolomics studies have shown that blood metabolite levels are predictive of insulin resistance and type 2 diabetes in the general population as well as sensitive to the effects of antipsychotics. In this study, we aimed to identify the metabolite profiles predicting future weight gain and other metabolic abnormalities in psychotic patients. We applied comprehensive metabolomics to investigate serum metabolite profiles in a prospective study setting in 36 first-episode psychosis patients during the first year of the antipsychotic treatment and 19 controls. While corroborating several earlier findings when comparing cases and controls and the effects of the antipsychotic medication, we also found that prospective weight gain in psychotic patients was associated with increased levels of triacylglycerols with low carbon number and double-bond count at baseline, that is, lipids known to be associated with increased liver fat. Our study suggests that metabolite profiles may be used to identify the psychotic patients most vulnerable to develop metabolic co-morbidities, and may point to a pharmacological approach to counteract the antipsychotic-induced weight gain.
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