| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
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| 3. |
-
- 2019
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Tidskriftsartikel (refereegranskat)
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| 4. |
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| 5. |
- Schuettpelz, Eric, et al.
(författare)
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A community-derived classification for extant lycophytes and ferns
- 2016
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Ingår i: Journal of Systematics and Evolution. - : Wiley. - 1674-4918 .- 1759-6831. ; 54:6, s. 563-603
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Tidskriftsartikel (refereegranskat)abstract
- Phylogeny has long informed pteridophyte classification. As our ability to infer evolutionary trees has improved, classifications aimed at recognizing natural groups have become increasingly predictive and stable. Here, we provide a modern, comprehensive classification for lycophytes and ferns, down to the genus level, utilizing a community-based approach. We use monophyly as the primary criterion for the recognition of taxa, but also aim to preserve existing taxa and circumscriptions that are both widely accepted and consistent with our understanding of pteridophyte phylogeny. In total, this classification treats an estimated 11 916 species in 337 genera, 51 families, 14 orders, and two classes. This classification is not intended as the final word on lycophyte and fern taxonomy, but rather a summary statement of current hypotheses, derived from the best available data and shaped by those most familiar with the plants in question. We hope that it will serve as a resource for those wanting references to the recent literature on pteridophyte phylogeny and classification, a framework for guiding future investigations, and a stimulus to further discourse.
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| 6. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 7. |
- Cheng, Shi-Ping, et al.
(författare)
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Haplotype-resolved genome assembly and allele-specific gene expression in cultivated ginger
- 2021
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Ingår i: Horticulture Research. - : Springer Nature. - 2052-7276. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Ginger (Zingiber officinale) is one of the most valued spice plants worldwide; it is prized for its culinary and folk medicinal applications and is therefore of high economic and cultural importance. Here, we present a haplotype-resolved, chromosome-scale assembly for diploid ginger anchored to 11 pseudochromosome pairs with a total length of 3.1 Gb. Remarkable structural variation was identified between haplotypes, and two inversions larger than 15 Mb on chromosome 4 may be associated with ginger infertility. We performed a comprehensive, spatiotemporal, genome-wide analysis of allelic expression patterns, revealing that most alleles are coordinately expressed. The alleles that exhibited the largest differences in expression showed closer proximity to transposable elements, greater coding sequence divergence, more relaxed selection pressure, and more transcription factor binding site differences. We also predicted the transcription factors potentially regulating 6-gingerol biosynthesis. Our allele-aware assembly provides a powerful platform for future functional genomics, molecular breeding, and genome editing in ginger.
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| 8. |
- Conti, David, V, et al.
(författare)
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
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Tidskriftsartikel (refereegranskat)abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
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| 9. |
- Han, Peigeng, et al.
(författare)
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Size effect of lead-free halide double perovskite on luminescence property
- 2019
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Ingår i: Science China Chemistry. - : Springer Science and Business Media LLC. - 1674-7291 .- 1869-1870. ; 62:10, s. 1405-1413
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Tidskriftsartikel (refereegranskat)abstract
- Lead-free halide double perovskites have gathered wide scientific interest since they are environmentally friendly and stable. However, compared to the lead perovskites, their optoelectronic properties are compromised. Herein we report a series of bulk lead-free mixed Bi-In halide double perovskites: Cs2AgBi1−xInxCl6 (0
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| 10. |
- He, Mao Qiang, et al.
(författare)
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Phylogenomics, divergence times and notes of orders in Basidiomycota
- 2024
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Ingår i: Fungal Diversity. - 1560-2745 .- 1878-9129. ; 126, s. 127-406
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Tidskriftsartikel (refereegranskat)abstract
- Basidiomycota is one of the major phyla in the fungal tree of life. The outline of Basidiomycota provides essential taxonomic information for researchers and workers in mycology. In this study, we present a time-framed phylogenomic tree with 487 species of Basidiomycota from 127 families, 47 orders, 14 classes and four subphyla; we update the outline of Basidiomycota based on the phylogenomic relationships and the taxonomic studies since 2019; and we provide notes for each order and discuss the history, defining characteristics, evolution, justification of orders, problems, significance, and plates. Our phylogenomic analysis suggests that the subphyla diverged in a time range of 443–490 Myr (million years), classes in a time range of 312–412 Myr, and orders in a time range of 102–361 Myr. Families diverged in a time range of 50–289 Myr, 76–224 Myr, and 62–156 Myr in Agaricomycotina, Pucciniomycotina, and Ustilaginomycotina, respectively. Based on the phylogenomic relationships and divergence times, we propose a new suborder Mycenineae in Agaricales to accommodate Mycenaceae. In the current outline of Basidiomycota, there are four subphyla, 20 classes, 77 orders, 297 families, and 2134 genera accepted. When building a robust taxonomy of Basidiomycota in the genomic era, the generation of molecular phylogenetic data has become relatively easier. Finding phenotypical characters, especially those that can be applied for identification and classification, however, has become increasingly challenging.
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| 11. |
- Huang, Hongyun, et al.
(författare)
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Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
- 2018
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Ingår i: Cell Transplantation. - : SAGE Publications. - 0963-6897 .- 1555-3892. ; 27:2, s. 310-324
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Forskningsöversikt (refereegranskat)abstract
- Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.
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| 12. |
- Liu, Hui, et al.
(författare)
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Centromere-Specific Retrotransposons and Very-Long-Chain Fatty Acid Biosynthesis in the Genome of Yellowhorn (Xanthoceras sorbifolium, Sapindaceae), an Oil-Producing Tree With Significant Drought Resistance
- 2021
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Ingår i: Frontiers in Plant Science. - : Frontiers Media S.A.. - 1664-462X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- In-depth genome characterization is still lacking for most of biofuel crops, especially for centromeres, which play a fundamental role during nuclear division and in the maintenance of genome stability. This study applied long-read sequencing technologies to assemble a highly contiguous genome for yellowhorn (Xanthoceras sorbifolium), an oil-producing tree, and conducted extensive comparative analyses to understand centromere structure and evolution, and fatty acid biosynthesis. We produced a reference-level genome of yellowhorn, ∼470 Mb in length with ∼95% of contigs anchored onto 15 chromosomes. Genome annotation identified 22,049 protein-coding genes and 65.7% of the genome sequence as repetitive elements. Long terminal repeat retrotransposons (LTR-RTs) account for ∼30% of the yellowhorn genome, which is maintained by a moderate birth rate and a low removal rate. We identified the centromeric regions on each chromosome and found enrichment of centromere-specific retrotransposons of LINE1 and Gypsy in these regions, which have evolved recently (∼0.7 MYA). We compared the genomes of three cultivars and found frequent inversions. We analyzed the transcriptomes from different tissues and identified the candidate genes involved in very-long-chain fatty acid biosynthesis and their expression profiles. Collinear block analysis showed that yellowhorn shared the gamma (γ) hexaploidy event with Vitis vinifera but did not undergo any further whole-genome duplication. This study provides excellent genomic resources for understanding centromere structure and evolution and for functional studies in this important oil-producing plant.
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| 13. |
- Mao, Wenxuan, et al.
(författare)
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Regioisomerically pure multiaryl coronene derivatives : highly efficient synthesis via bay-extended perylene tetrabutylester
- 2017
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Ingår i: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 53:36, s. 5052-5055
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Tidskriftsartikel (refereegranskat)abstract
- By a facile strategy, we obtained three pure regioisomers of multiaryl coronene bisimide (CBI) derivatives via IBr-mediated annelation and subsequent Suzuki coupling reactions with high yields. A series of aromatic groups with different electron properties were efficiently introduced to obtain functional CBI derivatives under mild conditions with good yields. Furthermore, the annelation mechanism as well as the optical and electrochemical properties of CBI derivatives were further investigated.
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| 14. |
- Mao, Xin
(författare)
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A Levinasian Reconstruction of the Political Significance of Vulnerability
- 2019
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Ingår i: Religions. - : MDPI AG. - 2077-1444. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- The concept of vulnerability has been renewed in meaning and importance over recent decades. Scholars such as Judith Butler, Martha Fineman and Pamela Sue Anderson have endeavored to redeem vulnerability from its traditional signification as a negative individual condition, and to reveal the positive meaning of vulnerability as a transformative call for solidarity, equality and love. In this paper we examine the newly constructed positive understanding of vulnerability, and argue that the current way of pursuing this positive understanding affirms a merely functional positivity. In the recent accounts, vulnerability is still a status to avoid, yet functions positively as a corrective force to the environment that produces vulnerability. We will try to find an essential way of designating the positivity of vulnerability by revisiting the philosophical discussion on vulnerability in Emmanuel Levinas. We will argue that Levinas’s notion of vulnerability is positive in a sense which goes beyond the purely functional; it is seen as essential for his definition of humanity. Yet compared to the contemporary discussion, Levinas’s notion of vulnerability lacks a direct social political meaning. We will tentatively explore how the essential positivity drawn from Levinas can provide a new way to construct the political significance of vulnerability.
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| 15. |
- Mao, Xin
(författare)
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Religion's Ambivalent Relation with Violence : From Scott Appleby to Emmanuel Levinas
- 2019
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Ingår i: Religions. - : MDPI AG. - 2077-1444. ; 10:11
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Tidskriftsartikel (refereegranskat)abstract
- The recent debate on the relation between certain religious traditions and violence has offered us multiple perspectives on this issue. Some scholars accept the conflictual image of religion in the contemporary time projected by the media, seeking the reason for religion’s supposedly violent nature. Some scholars have completely rejected the association between violence and religion, defending religion against what they see as a myth. Faced with difficulty reaching any consensus, R. Scott Appleby addresses the complexity of the phenomenon through the notion of ambivalence. His approach accommodates the revolutionary moments of religion and offers us a comprehensive perspective on the violence used by religious actors. In this paper, however, I will argue that Appleby fails to distinguish between violence on an ontological level and violence as means to achieve justice. I will introduce the notion of ambivalence as it appears in Emmanuel Levinas’s philosophy to construct an alternative theory about religion’s ambivalent attitude towards violence, where violence is limited to its role in justice but is yet transcended by religious infinite love. With this extended meaning of ambivalence, I will be able to confirm that the interhuman encounter implied in one’s relation to the sacred should be prioritised in addressing religious violence.
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| 16. |
- Mao, Xin
(författare)
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The religiosity of populism : The sanctified and abused power of the people
- 2017
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Ingår i: Journal for the Study of Religions and Ideologies. - 1583-0039. ; 16:47, s. 62-75
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Tidskriftsartikel (refereegranskat)abstract
- Populism, irrespective of its form as a political movement or ideological phenomenon, often has certain semi-religious characteristics. This article explores the religiosity of populism from two perspectives: the sacredness of the people, and the messianic character of the populist leader. Even within quotidian politics, the concept of “the people” within the national borders is generally given a prominent position; but it takes on a transcendental character within the context of populism. Similar to the absence of God in the system of signifiers, in populism the people is also an “empty signifier”, equivocation on which is sanctified, and utilized for exclusionary purposes. Additionally, the people is often associated with a grassroots class, in many cases initiating an antiintellectualist trend where “the people” are placed above secular, democratic political institutions. The leader, the other main actor in the various populist movements, is often seen as akin to a prophet who gives promises that outstrip reality and poses as a savior who will end all misfortune. The role of the populist leader can also be deemed religious, as he/she is described as the chosen one and often stands in direct relations of faith and love with each individual.
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| 17. |
- Mao, Xin
(författare)
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The three faces of vulnerability
- 2020
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Ingår i: Angelaki. - : Informa UK Limited. - 0969-725X .- 1469-2899. ; 25:1-2, s. 209-221
-
Tidskriftsartikel (refereegranskat)abstract
- Recent work by emerging “vulnerability theorists” has imbued the concept of vulnerability with new meaning that promises novel theoretical and social insights; however, these insights remain threatened by the innate ambiguity of the notion of vulnerability. The negative connotation of this term, namely the propensity to experience wounding, pain and marginalization, coexists with its positive connotation of an openness to love, care and the creation of solidarity. In this paper, we argue that this ambiguity calls for a clarification in order for the newly established positivity to be properly channeled to imagining new forms of inter-human relations. Specifically, we adopt the phenomenological lens of “exposedness,” drawn from Emmanuel Levinas, placing the notion of vulnerability at the horizon of the relatedness and dynamics among the triad of the “I,” the other, and the third. My vulnerability to the other as an exposedness to excessive responsibility is the pre-original signifyingness of inter-human relations, that is, as “for the other” before “for oneself.” The vulnerability of the other in the form of the relation of Eros will be differentiated from the vulnerability of the other as immediacy. The vulnerability of the third will be discussed from a socio-political perspective, where we will engage with Martha Fineman’s idea of universal vulnerability as a tool for social-political criticism, and further show how a Levinasian perspective on the third can address potential problems with Fineman’s proposals.
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| 18. |
- Mao, Xin
(författare)
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Transformation from Real-Centredness to Other-Centredness : A Levinasian Re-Appraisal of John Hick’s Religious Pluralism
- 2018
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Ingår i: Religions. - : MDPI AG. - 2077-1444. ; 9:9
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Tidskriftsartikel (refereegranskat)abstract
- John Hick’s theory of religious pluralism has from its birth faced critiques regarding both its conceptual framework and its religious outlook; yet even so, his philosophy continues to challenge us to strive for a greater sense of openness and equality as regards other faiths that conflict with our own. The viability of Hick’s teaching today depends on a re-appraisal that enables it to surmount its theoretical difficulties. In this paper, we re-evaluate Hick’s philosophy of religion, focusing on the underlying ethical importance of his claim regarding soteriological transformation. Despite the problematic notion of the noumenal Real and its role in religious pluralism, the soteriological transformation claimed by Hick, which goes from self-centredness toward Real-centredness, reveals a commitment to self-opening and compassion towards the others. Yet we will argue that Hick only gives this ethical importance a secondary status in his philosophy of religion, which leaves open the question of the nature of the causality between the ultimate Reality and this ethical commitment. We thereby engage with the philosophy of Emmanuel Levinas, in search of an ethical dimension with a characteristic of infinity, which can offer religious pluralism a transcendent foundation without disregarding ethical primacy. Following Levinas, we will argue for a further transformation from reality-centredness towards other-centredness, by which messianic peace would take the place of ultimate Reality as the teleological value underpinning religious pluralism.
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| 19. |
- Qiu, Jian-xin, et al.
(författare)
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[Study of sensitivity to impulse noise in guinea pig, rat and mouse]
- 2004
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Ingår i: Zhonghua er bi yan hou ke za zhi. - 0412-3948. ; 39:8, s. 472-475
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study sensitivity to impulse noise in guinea pig, rat and mice. METHODS: Six groups were divided. Group I: Guinea pigs (n = 5) were exposed to 50 impulses of 160 dB SPL; Group II: Guinea pigs (n = 5) were exposed to 100 impulses of 160 dB SPL; Group III: Guinea pigs (n = 5) were exposed to 200 impulses of 160 dB SPL; Group IV: Guinea pigs (n = 6) were exposed 400 impulses of 160 dB SPL; Group V: Rats (n = 10) were exposed to 50 impulses of 160 dB SPL; Group VI: Mice (n = 10) were exposed to 50 impulses of 160 dB SPL. ABR thresholds were determined prior to, immediately, one day, one week, two weeks and four weeks after impulse noise exposure. RESULTS: The rat and mice were shown temporary threshold shift (TTS) and permanent threshold shift (PTS) after 50 times impulse noise (160), while no TTS and PTS in the guinea pigs but it was shown TTS and PTS after 400 times impulse noise (160). CONCLUSIONS: Sensitivity to impulse noise is different among guinea pig, rat and mouse. Guinea pig has less sensitivity to impulse noise while rat and mouse have higher sensitivity to impulse noise. In addition, rat has higher sensitivity to impulse noise than mouse.
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| 20. |
- Ringh, Axel, et al.
(författare)
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Gain and phase type multipliers for structured feedback robustness
- 2022
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- It is known that the stability of a feedback interconnection of two linear time-invariant systems implies that the graphs of the open-loop systems are quadratically separated. This separation is defined by an object known as the multiplier. The theory of integral quadratic constraints shows that the converse also holds under certain conditions. This paper establishes that if the feedback is robustly stable against certain structured uncertainty, then there always exists a multiplier that takes a corresponding form. In particular, if the feedback is robustly stable to certain gain-type uncertainty, then there exists a corresponding multiplier that is of phase-type, i.e., its diagonal blocks are zeros. These results build on the notion of phases of matrices and systems, which was recently introduced in the field of control. Similarly, if the feedback is robustly stable to certain phase-type uncertainty, then there exists a gain-type multiplier, i.e., its off-diagonal blocks are zeros. The results are meaningfully instructive in the search for a valid multiplier for establishing robust closed-loop stability, and cover the well-known small-gain and the recent small-phase theorems.
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| 21. |
- Vermeer, Maarten H, et al.
(författare)
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Novel and highly recurrent chromosomal alterations in Sézary syndrome
- 2008
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 68:8, s. 2689-2698
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Tidskriftsartikel (refereegranskat)abstract
- This study was designed to identify highly recurrent genetic alterations typical of Sezary syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing pathogenetic mechanisms and novel therapeutic targets. High-resolution array-based comparative genomic hybridization was done on malignant T cells from 20 patients. Expression levels of selected biologically relevant genes residing within loci with frequent copy number alteration were measured using quantitative PCR. Combined binary ratio labeling-fluorescence in situ hybridization karyotyping was done on malignant cells from five patients. Minimal common regions with copy number alteration occurring in at least 35% of patients harbored 15 bona fide oncogenes and 3 tumor suppressor genes. Based on the function of the identified oncogenes and tumor suppressor genes, at least three molecular mechanisms are relevant in the pathogenesis of Sz. First, gain of cMYC and loss of cMYC antagonists (MXI1 and MNT) were observed in 75% and 40% to 55% of patients, respectively, which were frequently associated with deregulated gene expression. The presence of cMYC/MAX protein heterodimers in Sezary cells was confirmed using a proximity ligation assay. Second, a region containing TP53 and genome maintenance genes (RPA1/HIC1) was lost in the majority of patients. Third, the interleukin 2 (IL-2) pathway was affected by gain of STAT3/STAT5 and IL-2 (receptor) genes in 75% and 30%, respectively, and loss of TCF8 and DUSP5 in at least 45% of patients. In sum, the Sz genome is characterized by gross chromosomal instability with highly recurrent gains and losses. Prominent among deregulated genes are those encoding cMYC, cMYC-regulating proteins, mediators of MYC-induced apoptosis, and IL-2 signaling pathway components.
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| 22. |
- Wang, Anqi, et al.
(författare)
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074
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Tidskriftsartikel (refereegranskat)abstract
- The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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| 23. |
- Wang, Dan, et al.
(författare)
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On the phases of a semi-sectorial matrix and the essential phase of a Laplacian
- 2023
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Ingår i: Linear Algebra and its Applications. - : Elsevier BV. - 0024-3795 .- 1873-1856. ; 676, s. 441-458
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we extend the definition of phases of sectorial matrices to those of semi-sectorial matrices, which are possibly singular. Properties of the phases are also extended, including those of the Moore-Penrose generalized inverse, compressions and Schur complements, matrix sums and products. In particular, an interlacing relation is established between the phases of A+B and those of A and B combined. Also, a majorization relation is established between the phases of the nonzero eigenvalues of AB and the phases of the compressions of A and B, which leads to a generalized matrix small phase theorem. For the matrices which are not necessarily semi-sectorial, we define their (largest and smallest) essential phases via diagonal similarity transformation. An explicit expression for the essential phases of a Laplacian matrix of a directed graph is obtained.
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| 24. |
- Wang, Fang, et al.
(författare)
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Emerging contaminants: A One Health perspective
- 2024
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Ingår i: Innovation. - 2666-6758. ; 5
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Forskningsöversikt (refereegranskat)abstract
- Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both people and the planet. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the ongoing efforts to establish the UN's Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.
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| 25. |
- Wang, Keqing, et al.
(författare)
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Ultrasonic-Aided Fabrication of Nanostructured Au-Ring Microelectrodes for Monitoring Transmitters Released from Single Cells
- 2017
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 89:17, s. 8683-8688
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Tidskriftsartikel (refereegranskat)abstract
- We report a novel ultrasonic-aided fast and straightforward approach to fabricate Au microelectrodes by electroless deposition of nanostructured gold films on the rigid outer surface of pulled glass capillaries. Microelectrodes with tip diameters ranging from several hundred nanometers to several micrometers were fabricated within 20 min via three sequential ultrasonication steps. The ultrasonication technique has been validated to be a very effective route in engineering the morphology of Au film surfaces and improves the fabrication efficiency of Au microelectrodes. The nanostructured surfaces of the Au microelectrodes demonstrate excellent sensing activity and antifouling for dopamine oxidation. The microelectrodes were applied for measurement of catecholamines released from exocytosis events from single chromaffin cells and exhibited faster dynamic peak parameters, compared with carbon fiber microelectrodes. This report provides a generally accessible and complementary platform for analyzing catecholamines release events, which should be useful for new electrode designs and neurochemical sensing.
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| 26. |
- Wang, Kai, et al.
(författare)
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Zinc anode based alkaline energy storage system: Recent progress and future perspectives of zinc–silver battery
- 2024
-
Ingår i: Energy Storage Materials. - 2405-8297. ; 69
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Forskningsöversikt (refereegranskat)abstract
- Rechargeable zinc-based batteries have come to the forefront of energy storage field with a surprising pace during last decade due to the advantageous safety, abundance and relatively low cost, making them important supplements of lithium-ion batteries. As a significant role in zinc-based batteries, zinc-silver battery owns the advantages of high specific energy density, stable working voltage, high charging efficiency, safety and environmental friendliness, and it has been widely used in military such as in aerospace, deep water manned and civil field such as energy supply for watch and hearing aid. However, it is still suffering from a few drawbacks such as unsatisfactory cycle life, low utilization of the cathode. This review introduces the basic principles of zinc-silver batteries and elaborates the battery configurations aiming to understand its working mechanisms as well as the related issues. Most importantly, the very recent research updates and the concerns have arisen in the development are summarized from conventional cell to flexible device and hybrid device. Finally, the challenges and perspectives of zinc-silver batteries are further prospected to give a broad idea to readers new in the area and trigger inspirations for motivated researchers to further widen the utilization of silver-zinc batteries.
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| 27. |
- Wang, Saiwei, et al.
(författare)
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Model-Free Event-Triggered Optimal Consensus Control of Multiple Euler-Lagrange Systems via Reinforcement Learning
- 2021
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Ingår i: IEEE Transactions on Network Science and Engineering. - : IEEE. - 2327-4697. ; 8:1, s. 246-258
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Tidskriftsartikel (refereegranskat)abstract
- This paper develops a model-free approach to solve the event-triggered optimal consensus of multiple Euler-Lagrange systems (MELSs) via reinforcement learning (RL). Firstly, an augmented system is constructed by defining a pre-compensator to circumvent the dependence on system dynamics. Secondly, the Hamilton-Jacobi-Bellman (HJB) equations are applied to the deduction of the model-free event-triggered optimal controller. Thirdly, we present a policy iteration (PI) algorithm derived from reinforcement learning (RL), which converges to the optimal policy. Then, the value function of each agent is represented through a neural network to realize the PI algorithm. Moreover, the gradient descent method is used to update the neural network only at a series of discrete event-triggered instants. The specific form of the event-triggered condition is then proposed, and it is guaranteed that the closed-loop augmented system under the event-triggered mechanism is uniformly ultimately bounded (UUB). Meanwhile, the Zeno behavior is also eliminated. Finally, the validity of this approach is verified by a simulation example.
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| 28. |
- Yang, B, et al.
(författare)
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Lead-Free, Air-Stable All-Inorganic Cesium Bismuth Halide Perovskite Nanocrystals
- 2017
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 56:41, s. 12471-12475
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Tidskriftsartikel (refereegranskat)abstract
- Lead-based perovskite nanocrystals (NCs) have outstanding optical properties and cheap synthesis conferring them a tremendous potential in the field of optoelectronic devices. However, two critical problems are still unresolved and hindering their commercial applications: one is the fact of being lead-based and the other is the poor stability. Lead-free all-inorganic perovskite Cs3Bi2X9 (X=Cl, Br, I) NCs are synthesized with emission wavelength ranging from 400 to 560nm synthesized by a facile room temperature reaction. The ligand-free Cs3Bi2Br9 NCs exhibit blue emission with photoluminescence quantum efficiency (PLQE) about 0.2%. The PLQE can be increased to 4.5% when extra surfactant (oleic acid) is added during the synthesis processes. This improvement stems from passivation of the fast trapping process (2-20ps). Notably, the trap states can also be passivated under humid conditions, and the NCs exhibited high stability towards air exposure exceeding 30days.
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| 29. |
- Yang, Fu-Sheng, et al.
(författare)
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Chromosome-level genome assembly of a parent species of widely cultivated azaleas
- 2020
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Azaleas (Ericaceae) comprise one of the most diverse ornamental plants, renowned for their cultural and economic importance. We present a chromosome-scale genome assembly for Rhododendron simsii, the primary ancestor of azalea cultivars. Genome analyses unveil the remnants of an ancient whole-genome duplication preceding the radiation of most Ericaceae, likely contributing to the genomic architecture of flowering time. Small-scale gene duplications contribute to the expansion of gene families involved in azalea pigment biosynthesis. We reconstruct entire metabolic pathways for anthocyanins and carotenoids and their potential regulatory networks by detailed analysis of time-ordered gene co-expression networks. MYB, bHLH, and WD40 transcription factors may collectively regulate anthocyanin accumulation in R. simsii, particularly at the initial stages of flower coloration, and with WRKY transcription factors controlling progressive flower coloring at later stages. This work provides a cornerstone for understanding the underlying genetics governing flower timing and coloration and could accelerate selective breeding in azalea. Azaleas are one of the most diverse ornamental plants and have cultural and economic importance. Here, the authors report a chromosome-scale genome assembly for the primary ancestor of the azalea cultivar Rhododendro simsi and identify transcription factors that may function in flower coloration at different stages.
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| 30. |
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| 31. |
- Yu, Xin, et al.
(författare)
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Large-brained frogs mature later and live longer
- 2018
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Ingår i: Evolution. - : Wiley. - 0014-3820 .- 1558-5646. ; 72:5, s. 1174-1183
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Tidskriftsartikel (refereegranskat)abstract
- Brain sizes vary substantially across vertebrate taxa, yet, the evolution of brain size appears tightly linked to the evolution of life histories. For example, larger brained species generally live longer than smaller brained species. A larger brain requires more time to grow and develop at a cost of exceeded gestation period and delayed weaning age. The cost of slower development may be compensated by better homeostasis control and increased cognitive abilities, both of which should increase survival probabilities and hence life span. To date, this relationship between life span and brain size seems well established in homoeothermic animals, especially in mammals. Whether this pattern occurs also in other clades of vertebrates remains enigmatic. Here, we undertake the first comparative test of the relationship between life span and brain size in an ectothermic vertebrate group, the anuran amphibians. After controlling for the effects of shared ancestry and body size, we find a positive correlation between brain size, age at sexual maturation, and life span across 40 species of frogs. Moreover, we also find that the ventral brain regions, including the olfactory bulbs, are larger in long-lived species. Our results indicate that the relationship between life history and brain evolution follows a general pattern across vertebrate clades.
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| 32. |
- Zhang, Xiaoyu, et al.
(författare)
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Comparative Study on Pyrido[3,4-b]pyrazine-Based Sensitizers by Tuning Bulky Donors for Dye-Sensitized Solar Cells
- 2015
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 7:4, s. 2760-2771
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Tidskriftsartikel (refereegranskat)abstract
- Dye-sensitized solar cells (DSSCs) with cobalt electrolytes have gained increasing attention. In this Research Article, two new pyrido[3,4-b]pyrazine-based sensitizers with different cores of bulky donors (indoline for DT-1 and triphenylamine for DT-2) were designed and synthesized for a comparative study of their photophysical and electrochemical properties and device performance and were also analyzed through density functional theory calculations. The results of density function theory calculations reveal the limited electronic communication between the biphenyl branch at the cis-position of N-phenylindoline and the indoline core, which could act as an insulating blocking group and inhibit the dye aggregation and charge recombination at the interface of TiO2/dye/electrolyte. As expected, DSSCs based on DT-1 with cobalt redox electrolyte gained a higher photoelectric conversion efficiency of 8.57% under standard AM 1.5 G simulated sunlight, with J(sc) = 16.08 mA cm(-2), V-oc = 802 mV, and FF = 0.66. Both electrochemical impedance spectroscopy (EIS) and intensity-modulated photovoltage spectroscopy (IMVS) suggest that charge recombination in DSSCs based on DT-1 is much less than that in their counterparts of DT-2, owing to the bigger donor size and the insulating blocking branch in the donor of DT-1.
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| 33. |
- Zhang, X., et al.
(författare)
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Photovoltaic properties of bis(octyloxy)benzo-[c][1,2,5]thiadiazole sensitizers based on an N,N-diphenylthiophen-2-amine donor
- 2014
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Ingår i: Journal of Materials Chemistry C. - : Royal Society of Chemistry. - 2050-7526. ; 2:20, s. 4063-4072
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Tidskriftsartikel (refereegranskat)abstract
- Three D-A-π-A sensitizers (DOBT-IV to DOBT-VI) with N,N- diphenylthiophen-2-amine as the donor and bis(octyloxy)benzo-[c][1,2,5] thiadiazole (DOBT) as the auxiliary acceptor have been designed and synthesized. Their applications to dye-sensitized solar cells with I-/I 3 - and Co(ii)/(iii) electrolytes were measured and characterized. Via fine tuning of the π-bridge, the highest photoelectric conversion efficiency of 7.16% was obtained with Jsc = 16.88 mA cm-2, Voc = 0.662 V and FF = 64.03% for the DOBT-V based dye-sensitized solar cells using the I-/I3 - electrolyte under standard global AM1.5 solar conditions. A photoelectric conversion efficiency of 6.14% was obtained with Jsc = 11.35 mA cm-2, Voc = 0.760 V and FF = 71.16% with the Co(ii)/(iii) electrolyte under standard global AM1.5 solar conditions. The optical and electrochemical properties and the photovoltaic performance were evaluated and investigated using density functional theory calculations, a behavior study of the four performance parameters with dependence of the incident light intensity, electrochemical impedance spectroscopy and intensity-modulated photo-voltage spectrometry.
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