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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Marttila, H., et al.
(författare)
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Nordic hydrological frontier in the 21st century
- 2022
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Ingår i: Hydrology Research. - : IWA Publishing. - 1998-9563 .- 2224-7955 .- 0029-1277. ; 53:5, s. 700-715
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Tidskriftsartikel (refereegranskat)abstract
- The 21st century has brought new challenges and opportunities and has also increased demands on the Nordic hydrological community. Our hydrological science focus and approaches need rethinking and adaptation to the changing requirements of society in response to climate change and human interventions, in search of more comprehensive and cross-disciplinary solutions. This commentary highlights new possibilities and suggests vital steps forward for the scientific discipline within Nordic hydrological research. By providing a common direction, we hope to increase awareness, accelerate progress in the hydrological community, and emphasize the importance of hydrological knowledge for serving other fields of science and society at large. We hope that our vision and the opportunities we identify will raise awareness of the scientific discipline and assist in the long-term development of the Nordic hydrological frontier in the 21st century.
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| 8. |
- Jyväsjärvi, J., et al.
(författare)
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Climate-induced warming imposes a threat to north European spring ecosystems
- 2015
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Ingår i: Global Change Biology. - : Blackwell Publishing. - 1354-1013 .- 1365-2486. ; 21:12, s. 4561-4569
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Tidskriftsartikel (refereegranskat)abstract
- Interest in climate change effects on groundwater has increased dramatically during the last decade. The mechanisms of climate-related groundwater depletion have been thoroughly reviewed, but the influence of global warming on groundwater-dependent ecosystems (GDEs) remains poorly known. Here we report long-term water temperature trends in 66 northern European cold-water springs. A vast majority of the springs (82%) exhibited a significant increase in water temperature during 1968-2012. Mean spring water temperatures were closely related to regional air temperature and global radiative forcing of the corresponding year. Based on three alternative climate scenarios representing low (RCP2.6), intermediate (RCP6) and high-emission scenarios (RCP8.5), we estimate that increase in mean spring water temperature in the region is likely to range from 0.67 °C (RCP2.6) to 5.94 °C (RCP8.5) by 2086. According to the worst-case scenario, water temperature of these originally cold-water ecosystems (regional mean in the late 1970s: 4.7 °C) may exceed 12 °C by the end of this century. We used bryophyte and macroinvertebrate species data from Finnish springs and spring-fed streams to assess ecological impacts of the predicted warming. An increase in spring water temperature by several degrees will likely have substantial biodiversity impacts, causing regional extinction of native, cold-stenothermal spring specialists, whereas species diversity of headwater generalists is likely to increase. Even a slight (by 1 °C) increase in water temperature may eliminate endemic spring species, thus altering bryophyte and macroinvertebrate assemblages of spring-fed streams. Climate change-induced warming of northern regions may thus alter species composition of the spring biota and cause regional homogenization of biodiversity in headwater ecosystems.
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| 13. |
- Marttila, S, et al.
(författare)
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Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues
- 2022
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Ingår i: Epigenomics. - : Future Medicine Ltd. - 1750-192X .- 1750-1911. ; 14:18, s. 1105-1124
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Tidskriftsartikel (refereegranskat)abstract
- Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/ nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.
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| 14. |
- Michel, M., et al.
(författare)
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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
- 2022
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Ingår i: Science. - Stockholm : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 376:6600, s. 1471-1476
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Tidskriftsartikel (refereegranskat)abstract
- Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed b,d-lyase enzymatic function. TH10785 controls the catalytic activity mediated by a nitrogen base within its molecular structure. In cells, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. This alters the repair process, which no longer requires APE1 but instead is dependent on polynucleotide kinase phosphatase (PNKP1) activity. The increased repair of oxidative DNA lesions with a small molecule may have therapeutic applications in various diseases and aging. © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
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| 19. |
- Torabi Haghighi, A., et al.
(författare)
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A power market-based operation support model for sub-daily hydropower regulation practices
- 2019
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Ingår i: Applied Energy. - : Elsevier Ltd. - 0306-2619 .- 1872-9118. ; 255
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Tidskriftsartikel (refereegranskat)abstract
- With increasing power production from renewable energy sources, sub-daily variations in energy demand need to be balanced. Today, hydropower is commonly used as balancing power. In this study, we quantified the impact of capacity constraints, in terms of reservoir volume and hydropower capacity, on the potential to comply with instant energy demand. To evaluate the impact, we developed two new metrics, power market impact and system efficiency ratio, which are based on two threshold flow regimes derived from natural flow as lower threshold release and regulated flow (based on hourly energy prices) as upper threshold release. The operation support model comprises 96 different regulation scenarios based on varying combinations of hydropower and reservoir capacities. For each scenario, an hourly water balance was simulated, to obtain the highest complying with upper threshold release based on actual energy demand. We tested the framework on the Kemijoki river with defined thresholds based on the natural flow regime (tributary river Ounasjoki) and the hourly energy price in Finland in 2017, and estimated the impact of regulation on hourly flow regime at the Taivalkoski hydropower station. The annual flow regime impact in 2013, 2014 and 2015 was estimated to be 74%, 84% and 61%, respectively, while the monthly impact varied from 27% to 100%. Our framework for evaluating interactions between the power market and sub-daily regulation practices is a useful novel tool for sustainable river management and can be easily applied to different rivers and regions and evaluated for different timescales.
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| 20. |
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| 21. |
- Wahlström, L, et al.
(författare)
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Promoting health of people with intellectual disabilities: Views of professionals working in group homes
- 2014
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Ingår i: Journal of intellectual disabilities : JOID. - : SAGE Publications. - 1744-6309 .- 1744-6295. ; 18:2, s. 113-128
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Tidskriftsartikel (refereegranskat)abstract
- Deinstitutionalisation has influenced the life situation for people with intellectual disabilities, whilst the experiences of health promotion in group homes now are limited. This study aimed to explore aspects important to consider when promoting health amongst persons with intellectual disabilities in group homes, from the perspective of professionals. Semi-structured interviews were conducted with seven professionals and were analysed with thematic analysis. The overarching theme ‘sense of security’ was identified as a prerequisite for health promotion, together with the sub-themes ‘resources in the organisation’, for example, respectful treatment of the residents, and `resources of the residents', for example, meaningfulness and social connectedness. Findings were discussed from the perspective of health assets which is defined as the factors contributing to maintain and sustain health. The importance of strengthening external assets, that is, resources in the society and the organisation, to promote internal assets, that is, residents’ individual resources, and ultimately their health, is emphasised.
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