| 1. |
- Ahmadi, Fereshteh, 1958-, et al.
(författare)
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Religious/Spiritual Coping Methods among Cancer Patients in Portugal
- 2021
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Ingår i: Illness, crisis and loss. - : Sage. - 1054-1373 .- 1552-6968. ; 29:4, s. 301-326
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Tidskriftsartikel (refereegranskat)abstract
- The present article is part of an international study on meaning-making coping aimed at understanding the role of culture in coping in different cultural settings. The international study was conducted among cancer patients in ten countries. This article contains the results obtained in the study in Portugal. The main aim is to investigate the impact of culture on the meaning-making coping methods used by cancer patients. In the present article, only religious/spiritual coping methods are in focus.Thirty-one participants with various kinds of cancer (e.g., breast, testicular, lymphoma) were interviewed. Nine different kinds of coping methods related to religion and spirituality emerged from analysis of the interviews. These methods, which are categorized on the basis of RCOPE’s five basic religious functions (Pargament, 1997), are: Seeking Spiritual Support, Spiritual Connection, Spiritual Discontent, Benevolent Religious Reappraisal, Punishing God Reappraisal, God’s Trust in Personal Strength, Support from Clergy or Members, Self-Directing Religious Coping and Active Religious Surrender. The study confirms the notion that the strategies people employ when they are stricken by disease, accidents, misfortune, etc., are cultural and temporal constructions. As such, they are valid in concrete contexts and time periods. It is, thus, important that cultural context be taken into consideration when exploring the use of meaning-making coping strategies in different countries.
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| 2. |
- Ahmadi, Fereshteh, 1958-, et al.
(författare)
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Secular existential meaning-making coping among cancer patients in Portugal : A qualitative study
- 2022
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Ingår i: Illness, crisis and loss. - : Sage Publications. - 1054-1373 .- 1552-6968. ; 30:1, s. 68-88
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Tidskriftsartikel (refereegranskat)abstract
- For understanding the role of culture in coping in different cultural settings, we have conducted studies among cancer patients in 10 countries, within the framework of an international study on meaning-making coping. This article reports on part of the results we obtained from a study in Portugal; specifically, the reported findings are restricted to nonreligious/spiritual coping methods, methods we call secular existential meaning-making coping. The main aim is to identify the diversity of coping methods using a cultural lens. Thirty-one participants with various kinds of cancer were interviewed. Six different kinds of coping methods related to secular existential coping emerged from thematic analyses of the interviews: discourse of the self, positive solitude, nature, positive transformational orientation, body–mind relationship, and working. Findings revealed that these six methods facilitated patients’ psychological adaptation to the oncological disease. The findings suggest the importance of considering cultural and social context when exploring coping strategies among cancer patients.
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| 3. |
- Blaschikoff, Ludmilla, et al.
(författare)
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A multidisciplinary study of Iberian Chalcolithic dogs
- 2022
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Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 2352-409X .- 2352-4103. ; 42
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Tidskriftsartikel (refereegranskat)abstract
- Domesticated dogs have been present in the Iberian Peninsula long before other domesticated species, back to the late Palaeolithic period. Their origin is still uncertain, but dogs were already well established during the Chalcolithic period (ca. 5000-4000 BP). This study employed a multidisciplinary approach comprising osteometric, radiographic and palaeogenomic analyses to characterize Chalcolithic Iberian Canis remains. Two Chalcolithic archaeological sites - Leceia, Oeiras, in Portugal, and El Caset ' on de la Era, Villalba de los Alcores, Valladolid, in Spain - were the main focus of this study. Osteometric and odontometric data from eleven other sites in Iberia were also included. Osteometric results show signs of phenotypic variability, likely the result of human-driven selective pressure. Dental radiographic and dental wear analyses allowed age at death estimation for four individuals (two juvenile and two adults). Three Chalcolithic Iberian dogs had their mitogenomes resequenced and the mitochondrial DNA analysis allowed to assign each individual to two of the major known haplogroups - A and C. Molecular sex infered by the chromosomeX/chromosome1 coverage ratio allowed to identify one female and two males. This study unveils some aspects of the Iberian Chalcolithic dogs: these dogs already exhibited various morphotypes whose profiles might be associated to the performance of certain tasks, as well as mitogenomes of two distinct lineages that help tracking the evolutionary paths of Iberian dogs.
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| 4. |
- Ginja, Catarina, et al.
(författare)
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Iron age genomic data from Althiburos - Tunisia renew the debate on the origins of African taurine cattle
- 2023
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Ingår i: iScience. - : Cell Press. - 2589-0042. ; 26:7
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Tidskriftsartikel (refereegranskat)abstract
- The Maghreb is a key region for understanding the dynamics of cattle dispersal and admixture with local aurochs following their earliest domestication in the Fertile Crescent more than 10,000 years ago. Here, we present data on autosomal genomes and mitogenomes obtained for four archaeological specimens of Iron Age (∼2,800 cal BP–2,000 cal BP) domestic cattle from the Eastern Maghreb, i.e. Althiburos (El Kef, Tunisia). D-loop sequences were obtained for an additional eight cattle specimens from this site. Maternal lineages were assigned to the elusive R and ubiquitous African-T1 haplogroups found in two and ten Althiburos specimens, respectively. Our results can be explained by post-domestication hybridization of Althiburos cattle with local aurochs. However, we cannot rule out an independent domestication in North Africa considering the shared ancestry of Althiburos cattle with the pre-domestic Moroccan aurochs and present-day African taurine cattle.
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| 5. |
- Pires, Ana Elisabete, et al.
(författare)
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The curious case of the Mesolithic Iberian dogs : An archaeogenetic study
- 2019
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Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 0305-4403 .- 1095-9238. ; 105, s. 116-129
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the genetic composition of six Canis remains from western Iberia, directly radiocarbon dated to 7,903-7,570 years (cal BP). They were identified as dogs via their archaeological and depositional context, osteometry, and a high percentage of aquatic diet shared with humans. For comparison, genetic data were obtained from an additional 37 Iberian dog remains from the Neolithic to Late Antiquity, as well as two Palaeolithic and a Chalcolithic Canis identified as wolves. Previous data indicated that dog mtDNA haplogroup A (HgA) is prevalent in extant European dogs ( > 50%), in the Near East and Asia, but rare or absent ( < 10%) in European Canis older than 3,000 years (cal BP). We found a high frequency (83%) of dog HgA in Mesolithic Iberian dog remains. This is the first report of a high frequency of dog HgA in pre-Neolithic Europe. We show that, contrary to the current view, Canis with HgA did not necessarily arrive in Europe from East-Asia. This phylogeographical difference in HgA frequency demonstrates that genetic differentiation was high prior to, or as a consequence of, domestication which may be linked with pre-Neolithic local processes for Iberian wolf domestication. Our results emphasize that knowledge of both ancient wolves' and early dogs' genetic profiles from the European periphery should improve our understanding of the evolution of the European dog.
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| 6. |
- Pocas, Juliana, et al.
(författare)
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Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
- 2023
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 120:20
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Tidskriftsartikel (refereegranskat)abstract
- Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane pro-teoglycan, is highly expressed in intestinal subtype gastric tumors and that this sig -nature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and invasion. We also find that SDC4 decorated with heparan sulfate is efficiently sorted in extracellular vesicles (EVs). Interestingly, SDC4 in EVs regulates gastric cancer cell-derived EV organ distribution, uptake, and functional effects in recipient cells. Specifically, we show that SDC4 knockout disrupts the tropism of EVs for the common gastric cancer metastatic sites. Our findings set the basis for the molecular implications of SDC4 expression in gastric cancer cells and provide broader perspectives on the development of therapeutic strategies targeting the glycan-EV axis to limit tumor progression.
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