| 1. |
- Mattsson, Elisabet, et al.
(författare)
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Positive and negative consequences with regard to cancer during adolescence : Experiences two years after diagnosis
- 2007
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Ingår i: Psycho-Oncology. - : Wiley. - 1057-9249 .- 1099-1611. ; 16:11, s. 1003-1009
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The purpose was to explore negative and positive consequences of cancer during adolescence experienced two years after diagnosis. METHODS: Two years after diagnosis 38 persons, 15-21 years old, were asked two questions over the telephone: What, if anything, is bad for you due to the cancer disease? and What, if anything, is good for you due to the cancer disease? The answers were analysed by content analysis. RESULTS: Four categories of negative experiences were identified: a problematic body; unpleasant thoughts and feelings; outside the circle of friends; and difficulties with schoolwork. Six categories of positive experiences were identified: a more positive view of life; good self-esteem; knowledge and experience with regard to disease and hospital care; good relations; broader perspectives; and material gains. CONCLUSIONS: Two years after diagnosis those struck by cancer during adolescence experience not only a number of negative, but also positive, consequences of the cancer disease and its treatment.
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| 2. |
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| 3. |
- Afram, Gabriel, et al.
(författare)
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Higher response rates in patients with severe chronic skin graft-versus-host disease treated with extracorporeal photopheresis
- 2019
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Ingår i: Central European Journal of Immunology. - : TERMEDIA PUBLISHING HOUSE LTD. - 1426-3912 .- 1644-4124. ; 44:1, s. 84-91
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Different forms of graft-versus-host disease (GVHD) remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The prognosis for steroid-refractory chronic GVHD (cGVHD) remains poor. Our aim was to evaluate extracorporeal photopheresis (ECP) treatment in cGVHD patients with different organ involvement to detect subgroups of patients with the best response.Material and methods: Thirty-four patients who underwent HSCT and developed moderate (n = 7) or severe (n = 27) steroid-refractory or steroid-dependent cGVHD treated with ECP were included in the analysis. A matched cGVHD control patient group untreated with ECP was collected for comparison.Results: Compared to the control group and the stable/progressive disease (SD/PD) patients, individuals with complete/partial remission have higher overall survival and lower transplant-related mortality. Furthermore, patients with complete and partial remission (CR/PR) had significantly higher levels of albumin and platelets after ECP treatment compared to patients with stable or progressive cGVHD (SD/PD). Corticosteroid treatment and other immunosuppressive agents could successfully be tapered in the CR/PR group compared to the SD/PD patients. In this study patients with skin cGVHD are those with the highest rate of CR/PR after ECP treatment.Conclusions: Our results suggest that ECP treatment is safe and effective for patients with predominantly skin, oral and liver cGVHD.
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| 4. |
- Almqvist, Bjarne, et al.
(författare)
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Magnetic characterisation of magnetite and hematite from the Blötberget apatite-iron-oxide deposits (Bergslagen), south-central Sweden
- 2019
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Ingår i: Canadian journal of earth sciences (Print). - : Canadian Science Publishing. - 0008-4077 .- 1480-3313. ; 56:9, s. 948-957
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Tidskriftsartikel (refereegranskat)abstract
- Rock magnetic measurements were carried out on drill core material and hand specimens from the Blötberget apatite-iron oxide deposit in the Bergslagen ore province, south-central Sweden, to characterise their magnetic properties. Measurements included several kinds of magnetic susceptibility and hysteresis parameters. Petrographic and scanning electron microscopy (SEM) were used to independently identify and quantify the amount and type of magnetite and hematite. Two hematite-rich samples were studied with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to quantify the trace element chemistry in hematite and investigate the potential influence of trace elements on magnetic properties. Three aspects of this study are noteworthy. 1) Hematite-rich samples display strong anisotropy of magnetic susceptibility, which is likely to affect the appearance and modelling of magnetic anomalies. 2) The magnitude-drop in susceptibility across Curie and Néel temperature transitions show significant correlation with the respective weight percent (wt%) of magnetite and hematite. Temperature dependent magnetic susceptibility measurements can therefore be used to infer the amounts of both magnetite and hematite. 3) observations of a strongly depressed Morin transition at ca -60 to -70 C (200 to 210 K) are made during low-temperature susceptibility measurements. This anomalous Morin transition is most likely related to trace amounts of V and Ti that substitute for Fe in the hematite. When taken together, these magnetic observations improve the understanding of the magnetic anomaly signature of the Blötberget apatite-iron oxide deposits and may potentially be utilised in a broader context when assessing similar (Paleoproterozoic) apatite-iron oxide systems.
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| 5. |
- Baliakas, Panagiotis, 1977-, et al.
(författare)
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Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia
- 2019
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Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 104:2, s. 360-369
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Tidskriftsartikel (refereegranskat)abstract
- Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences. Considering this, we assessed prognosis separately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015 patients, hypothesizing that the relative significance of relevant indicators may differ between these two categories. Within Binet A M-CLL patients, besides TP53 abnormalities, trisomy 12 and stereotyped subset #2 membership were equivalently associated with the shortest time-to-first-treatment and a treatment probability at five and ten years after diagnosis of 40% and 55%, respectively; the remaining cases exhibited 5-year and 10-year treatment probability of 12% and 25%, respectively. Within Binet A U-CLL patients, besides TP53 abnormalities, del(11q) and/or SF3B1 mutations were associated with the shortest time-to-first-treatment (5- and 10-year treatment probability: 78% and 98%, respectively); in the remaining cases, males had a significantly worse prognosis than females. In conclusion, the relative weight of indicators that can accurately risk stratify early-stage CLL patients differs depending on the somatic hypermutation status of the immunoglobulin heavy variable genes of each patient. This finding highlights the fact that compartmentalized approaches based on immunogenetic features are necessary to refine and tailor prognostication in CLL.
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| 6. |
- Berglund, Sofia, et al.
(författare)
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Granulocyte transfusions could benefit patients with severe oral mucositis after allogeneic hematopoietic stem cell transplantation
- 2019
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Ingår i: Vox Sanguinis. - : Wiley-Blackwell. - 0042-9007 .- 1423-0410. ; 114:7, s. 769-777
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Tidskriftsartikel (refereegranskat)abstract
- Background and objectives Mucositis is a common complication after allogeneic hematopoietic stem cell transplantation (HSCT), and is caused by a combination of conditioning-induced mucosal damage and severe neutropenia. The symptoms include oral and abdominal pain, inability to swallow food and fluids, and severe diarrhoea. Severe mucositis is associated with increased risk of Graft-versus-Host disease and infection. Granulocyte transfusions (GCX) could be a treatment option, and our objective was to study its feasibility and potential benefits. Material and methods This retrospective, single-centre study included 30 patients receiving GCX because of severe oral mucositis after HSCT during 2005-2017. Clinical outcome, response to GCX, change in opiate administration and adverse events were studied. Results Twenty-seven patients received GCX from donors pre-treated with steroids and G-CSF, and three from donors pre-treated with steroids only. Overall response was 83% (24/29 evaluable patients). Fifteen patients reached a complete response. In 14 of 24 responders, a reduction of the administration of opiate pain relief was seen. In eight patients this reduction was >= 50% of the dose. Adverse events (AEs) were reported in 14 cases, and were mild to moderate, and well manageable with symptomatic treatment. No life-threatening or fatal AEs were recorded. Conclusions These results indicate that GCX could be a safe and effective treatment for oral mucositis after HSCT with the potential to reduce the necessity of opiate analgesic treatment in this disorder. No severe AEs were seen in this study, but the risk for severe pulmonary AEs after GCX needs to be considered.
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| 7. |
- Burzio, Cecilia, 1991, et al.
(författare)
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Removal of organic micropollutants in the biological units of a Swedish wastewater treatment plant
- 2021
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Ingår i: IOP Conference Series: Materials Science and Engineering. - 1757-8981 .- 1757-899X. ; 1209
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Konferensbidrag (refereegranskat)abstract
- The present study investigates the presence and removal of target organic micropollutants in a large Swedish wastewater treatment plant designed for nutrient removal including activated sludge, trickling filters, nitrifying moving bed biofilm reactors (MBBRs) and post-denitrifying MBBRs. A total of 28 organic micropollutants were analysed, at concentrations ranging from few ng/L to µg/L, in the influent and effluent of the different biological reactors in two sampling campaigns. The observed micropollutant removal efficiencies of the wastewater treatment plant varied from insignificant (< 20%) to high (> 90%) between compounds. The activated sludge reactor, being the first in line, contributed to most of the removal from the water phase. Additional removal of a few compounds was observed in the biofilm units, but most of the persistent compounds remained stable through all biological treatments.
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| 8. |
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| 9. |
- Duvetorp, Albert, et al.
(författare)
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A Cost-utility Analysis of Calcipotriol/Betamethasone Dipropionate Aerosol Foam versus Ointment for the Topical Treatment of Psoriasis Vulgaris in Sweden
- 2019
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Ingår i: Acta Dermato-Venereologica. - : ACTA DERMATO-VENEREOLOGICA. - 0001-5555 .- 1651-2057. ; 99:4, s. 393-399
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Tidskriftsartikel (refereegranskat)abstract
- Psoriasis is a chronic inflammatory disorder that imposes a substantial economic burden. We conducted a cost-utility analysis from a Swedish healthcare payers perspective using a decision-tree model with a 12-week time horizon. Patients with psoriasis vulgaris could have two 4-week cycles of topical treatment with calcipotriol 50 mu g/g and betamethasone 0.5 mg/g as dipropionate (Cal/BD) foam or Cal/BD ointment before progressing to phototherapy/methotrexate. In the base-case analysis, Cal/BD foam dominated over Cal/BD ointment. The increased efficacy of Cal/BD foam resulted in fewer consultations and a decreased risk of progressing to phototherapy/methotrexate. Although Cal/BD foam costs more than Cal/BD ointment, this was offset by lower costs for phototherapy/methotrexate or consultation visits. Sensitivity analyses revealed that the base-case net monetary benefit was robust to plausible variations in key parameters. In conclusion, Cal/BD foam was predicted to be more cost-effective than Cal/BD ointment in the treatment of psoriasis vulgaris.
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| 10. |
- Ehrenberg, Alexander J., et al.
(författare)
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Relevance of biomarkers across different neurodegenerative
- 2020
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Ingår i: Alzheimer's Research and Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 12
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Forskningsöversikt (refereegranskat)abstract
- Background: The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths, limitations, and biases that must be considered when investigating disease etiology and clinical utility. For example, neuropathological investigations of Alzheimer's disease pathogenesis can fall in disagreement with conclusions reached by biomarker-based investigations. Considering the varied strengths, limitations, and biases of different research methodologies and approaches may help harmonize disciplines within the neurodegenerative disease field. Purpose of review: Along with separate review articles covering fluid and imaging biomarkers in this issue of Alzheimer's Research and Therapy, we present the result of a discussion from the 2019 Biomarkers in Neurodegenerative Diseases course at the University College London. Here, we discuss themes of biomarker use in neurodegenerative disease research, commenting on appropriate use, interpretation, and considerations for implementation across different neurodegenerative diseases. We also draw attention to areas where biomarker use can be combined with other disciplines to understand issues of pathophysiology and etiology underlying dementia. Lastly, we highlight novel modalities that have been proposed in the landscape of neurodegenerative disease research and care.
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| 11. |
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| 12. |
- Gaballa, Ahmed, et al.
(författare)
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T-cell frequencies of CD8(+) gamma delta and CD27(+) gamma delta cells in the stem cell graft predict the outcome after allogeneic hematopoietic cell transplantation
- 2019
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Ingår i: Bone Marrow Transplantation. - : NATURE PUBLISHING GROUP. - 0268-3369 .- 1476-5365. ; 54:10, s. 1562-1574
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Tidskriftsartikel (refereegranskat)abstract
- The impact of intra-graft T cells on the clinical outcome after allogeneic hematopoietic cell transplantation has been investigated. Most previous studies have focused on the role of alpha beta cells while gamma delta cells have received less attention. It has been an open question whether gamma delta cells are beneficial or not for patient outcome, especially with regards to graft versus host disease. In this study, graft composition of.d cell subsets was analyzed and correlated to clinical outcome in 105 recipients who underwent allogeneic hematopoietic cell transplantation between 2013 and 2016. We demonstrate for the first time that grafts containing higher T-cell proportions of CD8(+) gamma delta cells were associated with increased cumulative incidence of acute graft versus host disease grade II-III (50% vs 22.6%; P = 0.008). Additionally, graft T-cell frequency of CD27(+) gamma delta cells was inversely correlated with relapse (P = 0.006) and CMV reactivation (P = 0.05). We conclude that clinical outcome after allogeneic hematopoietic cell transplantation is influenced by the proportions of distinct gamma delta cell subsets in the stem cell graft. We also provide evidence that CD8(+) gamma delta cells are potentially alloreactive and may play a role in acute graft versus host disease. This study illustrates the importance of better understanding of the role of distinct subsets of.d cells in allogeneic hematopoietic cell transplantation.
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| 13. |
- Gerhardsson, Emma, et al.
(författare)
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Developing the preterm breastfeeding attitudes instrument : A tool for describing attitudes to breastfeeding among health care professionals in neonatal intensive care
- 2021
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Ingår i: Midwifery. - : Elsevier BV. - 0266-6138 .- 1532-3099. ; 94
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The aim of this study was to develop an instrument that measures health care professionals' (HCPs) attitudes to breastfeeding and skin-to-skin contact in relation to the Baby-Friendly Hospital Initiative for neonatal intensive care.DESIGN: The study was part of a larger project aiming to revive the Ten Steps to Successful Breastfeeding for both full-term and preterm infants. The study had a pre-test/post-test design using online questionnaires distributed by email before and after a training programme.SETTING AND PARTICIPANTS: A total of 70 specialist registered nurses, registered nurses, assistant nurses and physicians working at a Swedish neonatal intensive care unit answered 55 breastfeeding attitudes questions online before the training. The Preterm Breastfeeding Attitudes Instrument (PreBAI) consists of twelve of these 55 items/questions, selected using exploratory factor analysis.MEASUREMENTS AND FINDINGS: Higher scores indicated more positive attitudes and the median total PreBAI score was 42 points (out of 48), on both the pre- and the post-test questionnaires, showing no significant difference. In the pre-test questionnaire, the majority of HCPs (84%) stated that they needed further breastfeeding training. They also stated that they perceived breastfeeding as very important, scoring a median of 10 (range 5-10) points on a 10-point scale. Three separate underlying dimensions were identified in the questionnaire, indicating different attitudes: Facilitating (five items), Regulating (four items), and Breastfeeding- and skin-to-skin contact-friendly (three items). A positive correlation was found between how many years the HCPs had worked in neonatal care, and their PreBAI score (rs = 0.383, p = 0.001). Those who had previously received extra breastfeeding education scored higher on the instrument.KEY CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: Neonatal intensive care units need to increase their efforts to support breastfeeding. An important factor for mothers when establishing breastfeeding is support from well-trained professionals with a positive attitude to breastfeeding. The PreBAI could be a useful tool for identifying attitudes among HCPs before and after attending a breastfeeding training programme.
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| 14. |
- Gerhardsson, Emma, et al.
(författare)
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Health care professionals report positive experience with a breastfeeding training program based on the Baby-Friendly Hospital Initiative for Neonatal Intensive Care
- 2023
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Ingår i: Journal of Perinatal & Neonatal Nursing. - : Elsevier. - 0893-2190 .- 1550-5073 .- 1355-1841 .- 1878-089X. ; 29:1, s. 75-80
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Tidskriftsartikel (refereegranskat)abstract
- Support from health care professionals (HCPs) with good knowledge and positive attitudes toward breastfeeding has been associated with better breastfeeding outcomes in the mothers of preterm infants. The aim of the study was to describe HCPs' experiences of a breastfeeding training program. A total of 48 specialist registered nurses, registered nurses, assistant nurses and physicians working at a neonatal intensive care unit attended a breastfeeding training program and answered a questionnaire including Likert scales and open-ended questions. The participants reported that their interest in breastfeeding had increased as a median (range) of 10 (8–10) on a 10-point scale and rated to what extent they had received new tools for breastfeeding support as a median of 10 (8–10) after training. There were no differences in the median between different professions' ratings. Qualitative content analysis of the open-ended questions resulted in two categories: Discussions of the case scenarios in the group and Knowledge regarding breastfeeding. The results showed that discussions based on breastfeeding scenarios were perceived as valuable; the health care professionals reported receiving new knowledge and useful practical skills. This program was shown to increase health care professionals’ interest in breastfeeding and is useful for different health care professions.
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| 15. |
- Gerhardsson, Emma, et al.
(författare)
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Mothers' Adaptation to a Late Preterm Infant When Breastfeeding
- 2020
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Ingår i: Journal of Perinatal & Neonatal Nursing. - : Wolters Kluwer. - 0893-2190 .- 1550-5073. ; 34:1, s. 88-95
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to psychometrically test the Adaptation to the Late Preterm Infant when Breastfeeding Scale (ALPIBS) and also to test how a mother's self-efficacy predicts adaptation to a late preterm infant when breastfeeding. This study had a longitudinal and prospective design, and data collection was consecutive. Mothers (n = 105) with infants born between and weeks were recruited from a neonatal intensive care unit or a maternity unit. The ALPIBS was developed using exploratory factor analysis, and the association between breastfeeding self-efficacy and ALPIBS score was examined using linear regression analysis. The Breastfeeding Self-Efficacy Scale-Short Form instrument was used to measure self-efficacy in breastfeeding. A higher degree of self-efficacy was significantly associated with a higher degree of adaptation to the late preterm infant's breastfeeding behavior (P < .001). We identified 4 separate underlying factors measured by 11 items in the ALPIBS: (A) breastfeeding is a stressful event; (B) the infant should breastfeed as often as he or she wants; (C) a mother has to breastfeed to be a good mother; and (D) it is important to ensure control over the infant's feeding behavior. There is a link between self-efficacy and ALPIBS score, and self-efficacy is a modifiable factor that influences breastfeeding.
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| 16. |
- Gerhardsson, Emma, et al.
(författare)
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Prospective questionnaire study showed that higher self-efficacy predicted longer exclusive breastfeeding by the mothers of late preterm infants.
- 2018
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 107:5, s. 799-805
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Tidskriftsartikel (refereegranskat)abstract
- AIM: An important variable that influences breastfeeding outcomes is how confident a woman feels about her ability to breastfeed successfully at an early stage. We investigated breastfeeding self-efficacy in the mothers of late preterm infants.METHODS: This was a prospective, comparative study that focused on mothers who had delivered babies at 34 + 0 to 36 + 6 weeks and were recruited in 2012-2015 from a neonatal intensive care unit and a postnatal ward at a Swedish university hospital. The Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) was used to psychometrically assess the mothers at 40 weeks of postmenstrual age (n = 148) and at three months of corrected age (n = 114).RESULTS: The BSES-SF scores were higher in the 87% of mothers that exclusively breastfed when their babies reached 40 weeks (57.1 out of 70) than those who did not (41.4, p < 0.001), indicating better self-efficacy. The figures remained higher in the 68% of exclusive breastfeeding mothers at three months of corrected age (60.9 versus 51.7).CONCLUSION: Self-efficacy was an important predictor of the length of breastfeeding in mothers of late preterm infants, and the BSES-SF can be used to detect low self-efficacy that could lead to early breastfeeding cessation.
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| 17. |
- Gerhardsson, Emma, et al.
(författare)
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The Swedish Version of the Breastfeeding Self-Efficacy Scale-Short Form : Reliability and Validity Assessment
- 2014
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Ingår i: Journal of Human Lactation. - : Sage Publications. - 0890-3344 .- 1552-5732. ; 30:3, s. 340-345
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Tidskriftsartikel (refereegranskat)abstract
- Background: Among Swedish mothers, breastfeeding duration has been declining in recent years. An instrument for early identification of women at risk for shorter breastfeeding duration may be useful in reversing this trend. Objectives: The aims of this study were to translate and psychometrically test the Swedish version of the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF), examine the relationship between breastfeeding self-efficacy and demographic variables, and evaluate associations with breastfeeding continuation plans in Swedish mothers. Methods: The BSES-SF was translated into Swedish using forward and back translation. The sample consisted of 120 mothers who, during the first week postpartum, came for a routine follow-up visit at the postnatal unit in a university hospital. The mothers were compared based on demographic data and their future breastfeeding plans. Results: The Cronbach’s alpha coefficient for internal consistency for the BSES-SF was 0.91 and the majority of correlation coefficients exceeded 0.3. A 1-factor solution was found that explained 46% of the total variance. There was no difference in confidence in breastfeeding between mothers with early hospital discharge and mothers who received postnatal care at the hospital. Primiparas who stayed longer at the hospital were less confident in breastfeeding than primiparas who had a shorter hospital stay. Breastfeeding mothers who planned to partially breastfeed in the near future had lower BSES-SF scores, compared to those who planned to continue exclusive breastfeeding. Conclusion: The Swedish version of the BSES-SF has good reliability, validity, and agreement with mothers’ plans regarding breastfeeding continuation and exclusivity.
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| 18. |
- Gissén, Charlott, et al.
(författare)
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Comparing energy crops for biogas production Yields, energy input and costs in cultivation using digestate and mineral fertilisation
- 2014
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Ingår i: Biomass & Bioenergy. - : Elsevier BV. - 1873-2909 .- 0961-9534. ; 64, s. 199-210
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Tidskriftsartikel (refereegranskat)abstract
- Analyses of six crops grown in southern Sweden for biogas production (hemp, sugar beet, maize, triticale, grass/clover ley, winter wheat) showed varying performance regarding methane yield per hectare and energy input and costs in the production and supply of crops as biogas feedstock. The highest biomass and biogas yield was observed for sugar beet. Crops with lower risk of negative environmental impact in cultivation, such as ley and hemp, produced less than half the methane energy yield per hectare. Triticale, also having less risk of negative environmental impact, gave an energy yield similar to that of winter wheat grain and maize. Replacing most of the mineral fertiliser with biogas digestate did not, with the exception for hemp, influence crop yields per hectare, but energy input in cultivation decreased by on average 34% for the six crops tested. For hemp and sugar beet the biogas feedstock costs for the freshly harvested crop per GJ methane were close to that of the economic reference crop, winter wheat grain. For maize, beet tops and first and second year ley, the feedstock costs were lower, and for triticale much lower. When ensiled crops were used for biogas the feedstock costs increased and only those of triticale silage remained slightly lower than the cost of dried wheat grain. However, all feedstock costs were so high that profitable biogas production based solely on ensiled crops would be difficult to achieve at present Swedish biogas sales prices. (c) 2014 Elsevier Ltd. All rights reserved.
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| 19. |
- Gustafsson, Britt M., et al.
(författare)
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Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia : An investigation of neonatal blood spots
- 2018
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Ingår i: Pediatric Blood & Cancer. - : WILEY. - 1545-5009 .- 1545-5017. ; 65:11
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Tidskriftsartikel (refereegranskat)abstract
- SCL/TAL1 interrupting locus (STIL)-T-cell acute leukaemia (TAL1) fusion genes are present in approximately 11-27% of children with paediatric T-cell acute lymphoblastic leukaemia (T-ALL), but the developmental timing of the rearrangement is still unknown. To investigate whether the fusion gene can be detected in neonatal blood spots (NBSs) from paediatric patients diagnosed with T-cell ALL, we analysed DNA from 38 paediatric patients with T-ALL by nested polymerase chain reaction and electrophoresis. The STIL-TAL1 fusion gene was not detected in NBSs from any of the 38 patients with T-ALL, suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-ALL.
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| 20. |
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| 21. |
- Hellberg, Emma, et al.
(författare)
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Evaluation of dissolution techniques for orally disintegrating mini-tablets
- 2021
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Ingår i: Journal of Drug Delivery Science and Technology. - : Elsevier. - 1773-2247. ; 61
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Tidskriftsartikel (refereegranskat)abstract
- Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and conventional techniques may have to be adopted. The main objective of the study was to evaluate different dissolution techniques for orally disintegrating mini-tablets. Dissolution tests using mini-paddle apparatus were compared with standard size paddle apparatus, and the effect of paddle rotation speed was evaluated. Also, the filter choice, and its impact on dissolution, was considered. Sodium salicylate was used as a model drug substance and was mixed with different size fractions of mannitol. The powder mixtures were compacted into 2 mm flat faced tablets. The mini-tablets were characterized regarding weight and content uniformity, tensile strength, friability, disintegration and dissolution. Similar dissolution profiles were obtained with both mini and standard equipment. The paddle rotation speed affected the dissolution profiles; a low paddle speed resulted in a slower dissolution. Furthermore, choosing a chemically inert filter will increase the likelihood of obtaining reliable and accurate results. An appropriately designed dissolution test using mini-paddle apparatus is required prior to further implementation in quality control procedures.
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| 22. |
- Jöud, Anna, et al.
(författare)
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Infertility, pregnancy loss and assisted reproduction in women with asthma : a population-based cohort study
- 2022
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Ingår i: Human Reproduction. - : Oxford University Press (OUP). - 0268-1161 .- 1460-2350. ; 37:12, s. 2932-2941
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Tidskriftsartikel (refereegranskat)abstract
- STUDY QUESTION: Is the chance of childbirth, and risk of infertility, pregnancy loss and need for assisted reproduction different for women with asthma compared to women without asthma?SUMMARY ANSWER: Women with asthma had comparable chances of giving birth compared to the reference population, however, their risk of both infertility and pregnancy loss, as well their need for medically assisted reproduction, was higher.WHAT IS KNOWN ALREADY: Reproductive dysfunction has been reported among women with asthma, including longer time to pregnancy, increased risk of pregnancy loss and a higher need of medically assisted reproduction, but their risk of clinical infertility is unknown.STUDY DESIGN, SIZE, DURATION: This longitudinal register-based cohort study included all women with a healthcare visit for delivery, infertility, pregnancy loss or induced abortion in the southernmost county in Sweden, over the last 20 years.PARTICIPANTS/MATERIALS, SETTING, METHODS: Using the Skåne Healthcare Register, we identified all women aged 15-45 between 1998 and 2019, who received a diagnosis of asthma before their first reproductive outcome (n = 6445). Chance of childbirth and risk of infertility, pregnancy loss and assisted reproduction were compared to a healthcare seeking population of women without any asthma (n = 200 248), using modified Poisson regressions.MAIN RESULTS AND THE ROLE OF CHANCE: The chance of childbirth was not different between women with asthma versus those without, adjusted risk ratio (aRR) = 1.02, 95% CI: 1.01-1.03. The risk of seeking care for infertility was increased, aRR = 1.29, 95% CI: 1.21-1.39, and women with asthma more often needed assisted reproduction aRR = 1.34 95% CI: 1.18-1.52. The risk of suffering a pregnancy loss was higher, aRR = 1.21, 95% CI: 1.15-1.28, and induced abortions were more common, aRR = 1.15, 95% CI: 1.11-1.20, among women with asthma.LIMITATIONS, REASONS FOR CAUTION: The study was an observational study based on healthcare visits and lacked detailed anthropometric data, thus residual confounding cannot be excluded. Only women with a healthcare visit for a reproductive outcome were included, which cannot be translated into pregnancy intention. A misclassification, presumed to be non-differential, may arise from an incorrect or missing diagnosis of asthma or female infertility, biasing the results towards the null.WIDER IMPLICATIONS OF THE FINDINGS: This study points towards reproductive dysfunction associated with asthma, specifically in regards to the ability to maintain a pregnancy and the risk of needing medically assisted reproduction following clinical infertility, but reassuringly the chance of subsequently giving birth was not lower for these women.STUDY FUNDING/COMPETING INTEREST(S): This article is part of the ReproUnion collaborative study, co-financed by EU Interreg ÖKS, Capital Region of Denmark, Region Skåne and Ferring Pharmaceuticals. The authors have no competing interests to disclose.TRIAL REGISTRATION NUMBER: N/A.
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| 23. |
- Kirkeby, Agnete, et al.
(författare)
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Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD
- 2023
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Ingår i: Cell Stem Cell. - 1934-5909. ; 30:10, s. 1299-1314
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Tidskriftsartikel (refereegranskat)abstract
- Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in vivo to meet regulatory requirements. Importantly, no adverse effects were observed upon testing of the product in a 39-week rat GLP safety study for toxicity, tumorigenicity, and biodistribution, and a non-GLP efficacy study confirmed that the transplanted cells mediated full functional recovery in a pre-clinical rat model of PD. We further observed highly comparable efficacy results between two different GMP batches, verifying that the product can be serially manufactured. A fully in vivo-tested batch of STEM-PD is now being used in a clinical trial of 8 patients with moderate PD, initiated in 2022.
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| 24. |
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| 25. |
- lee, hower, et al.
(författare)
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Open-source, high-throughput targeted in-situ transcriptomics for developmental and tissue biology
-
Tidskriftsartikel (refereegranskat)abstract
- Multiplexed spatial profiling of mRNAs has recently gained traction as a tool to explore the cellular diversity and the architecture of tissues. We propose a sensitive, open-source, simple and flexible method for the generation of in-situ expression maps of hundreds of genes. We exploit direct ligation of padlock probes on mRNAs, coupled with rolling circle amplification and hybridization-based in situ combinatorial barcoding, to achieve high detection efficiency, high throughput and large multiplexing. We validate the method across a number of species, and show its use in combination with orthogonal methods such as antibody staining, highlighting its potential value for developmental and tissue biology studies. Finally, we provide an end-to-end computational workflow that covers the steps of probe design, image processing, data extraction, cell segmentation, clustering and annotation of cell types. By enabling easier access to high-throughput spatially resolved transcriptomics, we hope to encourage a diversity of applications and the exploration of a wide range of biological questions.
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| 26. |
- Lee, Hower, et al.
(författare)
-
Open-source, high-throughput targeted in-situ transcriptomics for developmental biologists
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Multiplexed spatial profiling of mRNAs has recently gained traction as a tool to explore the cellular diversity and the architecture of tissues. We propose a sensitive, open-source, simple and flexible method for the generation of in-situ expression maps of hundreds of genes. We exploit direct ligation of padlock probes on mRNAs, coupled with rolling circle amplification and hybridization-based in situ combinatorial barcoding, to achieve high detection efficiency, high throughput, and large multiplexing. We validate the method across a number of species and show its use in combination with orthogonal methods such as antibody staining, highlighting its potential value for developmental biology studies. Finally, we provide an end-to-end computational workflow that covers the steps of probe design, image processing, data extraction, cell segmentation, clustering, and annotation of cell types. By enabling easier access to high throughput spatially resolved transcriptomics, we hope to encourage a diversity of applications and the exploration of a wide range of biological questions.
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| 27. |
- Li, Lu, 1964, et al.
(författare)
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The Importance of GLUT3 for De Novo Lipogenesis in Hypoxia-Induced Lipid Loading of Human Macrophages
- 2012
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 7:8
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Tidskriftsartikel (refereegranskat)abstract
- Atherosclerotic lesions are characterized by lipid-loaded macrophages (foam cells) and hypoxic regions. Although it is well established that foam cells are produced by uptake of cholesterol from oxidized LDL, we previously showed that hypoxia also promotes foam cell formation even in the absence of exogenous lipids. The hypoxia-induced lipid accumulation results from increased triglyceride biosynthesis but the exact mechanism is unknown. Our aim was to investigate the importance of glucose in promoting hypoxia-induced de novo lipid synthesis in human macrophages. In the absence of exogenous lipids, extracellular glucose promoted the accumulation of Oil Red O-stained lipid droplets in human monocyte-derived macrophages in a concentration-dependent manner. Lipid droplet accumulation was higher in macrophages exposed to hypoxia at all assessed concentrations of glucose. Importantly, triglyceride synthesis from glucose was increased in hypoxic macrophages. GLUT3 was highly expressed in macrophage-rich and hypoxic regions of human carotid atherosclerotic plaques and in macrophages isolated from these plaques. In human monocyte-derived macrophages, hypoxia increased expression of both GLUT3 mRNA and protein, and knockdown of GLUT3 with siRNA significantly reduced both glucose uptake and lipid droplet accumulation. In conclusion, we have shown that hypoxia-induced increases in glucose uptake through GLUT3 are important for lipid synthesis in macrophages, and may contribute to foam cell formation in hypoxic regions of atherosclerotic lesions.
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| 28. |
- Ljungman, Lisa, 1981-, et al.
(författare)
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"There should be some kind of checklist for the soul" - A qualitative interview study of support needs after end of treatment for gynecologic cancer in young women
- 2021
-
Ingår i: European Journal of Oncology Nursing. - : Elsevier. - 1462-3889 .- 1532-2122. ; 52
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: Young women diagnosed with a gynecologic cancer face the risk of significant physical and mental health problems after end of treatment. Still, there is a lack of knowledge regarding specific support needs in this population, and supportive care services provided to young women with a gynecologic cancer have been reported to be insufficient. The aim of this study was therefore to identify support needs experienced by women diagnosed with a gynecologic cancer before the age of 40.Method: Qualitative semi-structured interviews were conducted with participants (n = 10). Interviews were analyzed using content analysis with an inductive approach.Results: Eight categories and two themes were identified. The themes described if these needs were related to how women wanted the support to be provided, or to what the support should contain, i.e., 'Form' and 'Content', respectively. The categories related to 'Form' included: Outreach support; Long-term specialized support; Support for the whole family; and Peer-support, whereas categories related to 'Content' included needs for: Support for psychological reactions; Support related to reproduction, sexuality, and family life; Information regarding late effects; and Support tailored to younger women.Conclusion: Women diagnosed with a gynecologic cancer during young adulthood report several specific support needs. The results provide important guidance to clinicians and health care providers by outlining these needs both in terms of form and content.
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| 29. |
- Mattsson, Charlotte L, et al.
(författare)
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Differential involvement of caveolin-1 in brown adipocyte signaling : impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling.
- 2010
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Ingår i: Biochimica et Biophysica Acta. - : Elsevier BV. - 0006-3002 .- 1878-2434. ; 1803:8, s. 983-9
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Tidskriftsartikel (refereegranskat)abstract
- Caveolae and caveolin have been implicated as being involved in the signal transduction of many receptors, including the EGF, PDGF, LPA and beta3-adrenergic receptors. To investigate the role of caveolin-1 (Cav1) in these signaling pathways in brown adipose tissue, primary brown adipocyte cultures from Cav1-ablated mice and wild-type mice were investigated. In pre-adipocytes, Cav1-ablation affected neither the G-protein coupled LPA receptor signaling to Erk1/2, nor the receptor tyrosine kinases PDGF- or EGF-receptor signaling to Erk1/2. Mature primary Cav1-/- brown adipocytes accumulated lipids and expressed aP2 to the same extent as did wild-type cells. However, the cAMP levels induced by the beta3-adrenergic receptor agonist CL316,243 were lower in the Cav1-/- cultures, with an unchanged EC50 for CL316,243. Also the response to the direct adenylyl cyclase agonist forskolin was reduced. Thus, in brown adipocytes, Cav1 is apparently required for an intact response to adenylyl cyclase-linked agonists/activators, whereas other signaling pathways examined function without Cav1
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| 30. |
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| 31. |
- Mattsson, C. Mikael, et al.
(författare)
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NSAID inom multisport
- 2011
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Ingår i: Svensk IdrottsMedicin. - 1103-7652. ; 30:4, s. 18-21
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Användning av NSAID är mycket vanligt bland deltagare i längre multisporttävlingar. Ofta i tron att NSAID påskyndar återhämtningen, trots att kunskapen om dess påverkan vid idrott är begränsad. Det är till och med möjligt att NSAID har motsatt effekt och istället påverkar muskelåterhämtning och -uppbyggnad negativt.
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| 32. |
- Mattsson, C. Mikael, et al.
(författare)
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Träna för en svensk klassiker och andra långlopp
- 2015
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Bok (populärvet., debatt m.m.)abstract
- Förbered dig rätt inför långlopp. Att under ett år genomföra Vätternrundan, Vansbrosimningen, Lidingöloppet och Engelbrektsloppet/Vasaloppet, är ett av de mest populära sätten att skörda frukten av sin träning och nå sitt mål. För att lyckas krävs goda förberedelser, och ju bättre förberedd du är desto mer positiv blir upplevelsen. Innehållet i denna bok är en fördjupning av samlad kunskap och erfarenhet inom simning, cykel, löpning, längdskidåkning och triathlon samt hur man på bästa sätt kombinerar de olika idrotterna – deras olika moment – i träning och tävling. Här hittar du också kapitel om träningslära, idrottsnutrition, mental träning, förebyggande av idrottsskador och träningsplanering för att öka förståelsen av vad som påverkar en idrottsprestation.Extramaterial på webbplatsen: För att kunna erbjuda mer än vad som ryms i en bok, har vi också skapat en webbplats. Med hjälp av koden som följer med i boken kan du registrera dig för att ta del av fördjupande texter, träningsprogram och kostupplägg, övningar och intressanta länkar.(Text från förlaget)
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| 33. |
- Mattsson, Jenny, 1974, et al.
(författare)
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Get a Room! How Writing Groups Aid the Development of Junior Academics’ Writing Practice and Writer Identity
- 2020
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Ingår i: Journal of Academic Writing (JoAW). - : Coventry University, Lanchester Library. - 2225-8973. ; 10:1, s. 59-74
-
Tidskriftsartikel (refereegranskat)abstract
- The present study revisits writing retreat participants who have spontaneously formed writing groups before or after attending a retreat hosted by the Unit for Academic Language at the University of Gothenburg, Sweden. All in all, 11 doctoral students and one postdoc were interviewed using a semi-structured interview model. The answers were thematically analysed based on Murray’s (2014) concept of coherence in writing groups as well as parts of Aitchison and Lee’s (2006) key characteristics of writing groups. The two main research questions posed concern (i) whether the informants have changed their writing practice and/or the way they think and feel about writing since joining a writing group, and (ii) whether possible changes have aided the development of their identity as academic writers. Results show that the informants have indeed changed central aspects of their writing practice and that this in turn has positively influenced how they now think and feel about writing. This has to some extent contributed to the informants’ development of their writer identity; however, the present study also sheds light on the fact that more needs to be done at departmental levels across the university to make academic writing visible.
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| 34. |
- Mattsson, Kristina, et al.
(författare)
-
Fertility outcomes in women with pre-existing type 2 diabetes-a prospective cohort study
- 2021
-
Ingår i: Fertility and Sterility. - : Elsevier. - 0015-0282 .- 1556-5653. ; 116:2, s. 505-513
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study childbirth and the risk of miscarriage and infertility among women who have received a diagnosis of type 2 diabetes before the start of their reproductive journey.DESIGN: Register-based cohort study using the Skåne Healthcare Register SETTING: All healthcare visits for the whole population of the southernmost region in Sweden over the past 20 years PATIENT(S): All women who were aged 18-45 years between January 1, 1998 and December 31, 2019 and who received a clinical diagnosis of type 2 diabetes before their first childbirth, miscarriage, or infertility diagnosis (n = 230) were compared with a healthcare-seeking population of women without any type of diabetes, matched for calendar year and age (n = 179,434).INTERVENTION(S): None MAIN OUTCOME MEASURE(S): Childbirth, miscarriage, and infertility diagnosis RESULT(S): The birthrate was lower among women with type 2 diabetes (62.6% vs. 83.8%), and they were less likely to give birth (crude risk ratio [RR] = 0.73, 95% confidence interval [CI]: 0.66-0.81). They had a higher risk of experiencing a miscarriage (RR = 1.88, 95% CI: 1.50-2.36). The risk of infertility was increased (RR = 3.44, 95% CI: 2.88-4.10) as was the risk of having infertility and not giving birth (RR = 4.47, 95% CI: 3.44-5.82). All results remained the same after adjustment for polycystic ovary syndrome and obesity.CONCLUSION(S): Women with type 2 diabetes with onset before their reproductive journey were more often childless compared with women without diabetes and had a higher risk of experiencing both miscarriage and infertility. This patient group may be in need of targeted information regarding potential fertility issues as part of their clinical treatment.
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| 35. |
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| 36. |
- Mattsson, M, et al.
(författare)
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Dielectrophoresis-induced separation of metallic and semiconducting SWNT in a continuous flow microfluidic system
- 2007
-
Ingår i: Journal of Nanotechnology and Nanoscience. - : American Scientific Publishers. - 1533-4880. ; 7, s. 3431-3435
-
Tidskriftsartikel (refereegranskat)abstract
- The AC dielectrophoresis-induced separation of metallic and semiconducting single-wall carbon nanotubes has been carried out in a continuous flow microfluidic system with isolated electrodes. The separation has been studied for single-wall carbon nanotube aqueous suspensions with ionic (sodium dodecylsulphate) and non-ionic (TritonX-100) surfactants. The efficiency of separation has been determined with the help of resonant Raman spectroscopy using various excitation energies. The prototype microfluidic cell presently shows somewhat inferior separation efficiency with respect to static dielectrophoretic filtering on arrays of microelectrodes but has potential for improvements. Factors influencing the separation efficiency and scaling up of the process are discussed.
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| 37. |
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| 38. |
- Mellgren, Emma, et al.
(författare)
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The sound of potency : An observation study of nurses' approach to sound in a pediatric intensive care unit
- 2017
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Ingår i: Clinical Nursing Studies. - : Sciedu Press. - 2324-7940 .- 2324-7959. ; 5:2, s. 46-52
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The objective of this study was to investigate the nurses’ approach to three sources of sound that contribute to high noise levels; alarms, doors that open and conversation.Methods: Methods used derived from a theoretical perspective based on interpretive phenomenology and caring culture. In the pediatric intensive care, the caregivers of the children work in a high-tech environment as they are surrounded by sound from several sources. How caregivers understand and acknowledge how these sounds negatively affect a child’s well-being depends on their individual knowledge and awareness of how children are affected by sound. In most cases, coming into an intensive care unit is a new experience for a child. This causes greater stress, both from the environment itself as well as from sound levels. The method was built on a phenomenological perspective and an interpretive non-participation, semi-structured observations were conducted in a pediatric intensive care unit (PICU) of one of Sweden’s metropolitan regions in the winter of 2014-2015.Results: The results show that noise is an overlooked phenomenon in the pediatric intensive care environment as it has given way to other priorities in the nurse’s work. It is also apparent that this depends on the department’s caring culture as it prioritizes other things, resulting in normalizing high levels of noise as a part of the pediatric intensive care environment.Conclusions: Noise levels are not a priority in the department’s caring culture. High noise levels are permitted unreflectedly and appears to be a token of potency and an accepted part of the health care environment.
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| 39. |
- Ohlin, Acke, et al.
(författare)
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Titanium granules pre-treated with hydrogen peroxide inhibit growth of bacteria associated with post-operative infections in spine surgery
- 2018
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Ingår i: European Spine Journal. - : Springer Science and Business Media LLC. - 0940-6719 .- 1432-0932. ; 27:10, s. 2463-2468
-
Tidskriftsartikel (refereegranskat)abstract
- © 2018 The Author(s) Purpose: Post-operative infections are relatively common after posterior spine surgery, and there are several observations reflecting different infection complications related to various metals implanted. Here, we selected an array of different bacterial species that are often found in infections associated with orthopaedic implants and tested for inhibition by hydrogen peroxide-treated titanium (Ti-peroxy). Methods: To study the possibility of using Ti-peroxy as an antimicrobial prophylaxis, we developed a protocol for standardized susceptibility testing of bacteria. Results: Importantly, we found that the resulting Ti-peroxy was highly antimicrobial against all aerobic species tested, among others, Staphylococcus aureus and Pseudomonas aeruginosa. Proteus mirabilis was slightly more resistant than, for example, Klebsiella pneumoniae and enterococci. In contrast, anaerobic bacteria Cutibacterium acnes and Parvimonas micra were equally susceptible compared to staphylococci. Conclusions: Our findings suggest that the Ti-peroxy is a promising perioperative antimicrobial strategy that may be highly effective for prevention of post-operative infections. We therefore suggest application of hydrogen peroxide to implants prior to implantation. Graphical abstract: These slides can be retrieved under Electronic supplementary material.[Figure not available: see fulltext.]
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| 40. |
- Oljans, Emma, et al.
(författare)
-
From nutrients to wellbeing identifying discourses of food in relation to health in syllabi
- 2018
-
Ingår i: Pedagogy, Culture & Society. - : Informa UK Limited. - 1468-1366 .- 1747-5104. ; 26:1, s. 35-49
-
Tidskriftsartikel (refereegranskat)abstract
- Food and health have long had dominant position within the subject of Home Economics (HE) in Sweden. However, what constitutes a proper diet, and how it is associated with a healthy lifestyle changes over time. In this article, a discourse analytic approach combined with a didactic perspective are used as the theoretical frame. The aim is to explore how food in relation to health has been constructed within the syllabus of HE. Six HE syllabi from 1962 to 2011 were analysed. From the results three different discourses were identified and named after their main areas of focus: (i) the medical discourse, (ii) the consumer discourse and (iii) the human ecological discourse. Each discourse represents a different way of constructing food in relation to health, and different representations have dominated over the past fifty years. The construction of food in relation to health is thereby seen in its historical and cultural context according to what this knowledge content includes or excludes.
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| 41. |
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| 42. |
- Radestad, Emelie, et al.
(författare)
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Individualization of Hematopoietic Stem Cell Transplantation Using Alpha/Beta T-Cell Depletion
- 2019
-
Ingår i: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with several potentially lethal complications. Higher levels of CD3+ T-cells in the graft have been associated with increased risk of graft-versus-host disease (GVHD), but also beneficial graft-versus-leukemia effect and reduced infections. To tackle post-transplant complications, donor lymphocyte infusions have been used but with an increased risk of GVHD. To reduce this risk, we performed depletion of alpha beta T-cells and treated 12 patients post-HSCT suffering from infections and/or poor immune reconstitution. The alpha beta T-cell depleted cell products were characterized by flow cytometry. The median log depletion of alpha beta T-cells was -4.3 and the median yield of gamma delta T-cells was 73.5%. The median CD34+ cell dose was 4.4 x 10(6)/kg. All 12 patients were alive 3 months after infusion and after 1 year, two patients had died. No infusion-related side effects were reported and no severe acute GVHD (grade III-IV) developed in any patient post-infusion. Overall, 3 months after infusion 11 out of 12 patients had increased levels of platelets and/or granulocytes. In conclusion, we describe the use of alpha beta T-cell depleted products as stem cell boosters with encouraging results.
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| 43. |
- Remberger, Mats, et al.
(författare)
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Improved survival after allogeneic hematopoietic stem cell transplantation in recent years : A single-center study
- 2011
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 17:11, s. 1688-1697
-
Tidskriftsartikel (refereegranskat)abstract
- We analyzed the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) over the past 2 decades. Between 1992 and 2009, 953 patients were treated with HSCT, mainly for a hematologic malignancy. They were divided according to 4 different time periods of treatment: 1992 to 1995, 1996 to 2000, 2001 to 2005, and 2006 to 2009. Over the years, many factors have changed considerably regarding patient age, diagnosis, disease stage, type of donor, stem cell source, genomic HLA typing, cell dose, type of conditioning, treatment of infections, use of granulocyte-colony stimulating factor (G-CSF), use of mesenchymal stem cells, use of cytotoxic T cells, and home care. When we compared the last period (2006-2009) with earlier periods, we found slower neutrophil engraftment, a higher incidence of acute graft-versus-host disease (aGVHD) of grades II-IV, and less chronic GVHD (cGHVD). The incidence of relapse was unchanged over the 4 periods (22%-25%). Overall survival (OS) and transplant-related mortality (TRM) improved significantly in the more recent periods, with the best results during the last period (2006-2009) and a 100-day TRM of 5.5%. This improvement was also apparent in a multivariate analysis. When correcting for differences between the 4 groups, the hazard ratio for mortality in the last period was 0.59 (95% confidence interval [CI]: 0.44-0.79; P < .001) and for TRM it was 0.63 (CI: 0.43-0.92; P = .02). This study shows that the combined efforts to improve outcome after HSCT have been very effective. Even though we now treat older patients with more advanced disease and use more alternative HLA nonidentical donors, OS and TRM have improved. The problem of relapse still has to be remedied. Thus, several different developments together have resulted in significantly lower TRM and improved survival after HSCT over the last few years.
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| 44. |
- Rhodes, Emma, 1990-, et al.
(författare)
-
Insights into the magmatic processes of a shallow, silicic storage zone: Reyðarártindur Pluton, Iceland
- 2019
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Reyðarártindur is one of several felsic plutons exposed in Southeast Iceland, interpreted to be the shallow plumbing systems of late Neogene volcanic centres (Cargill et al., 1928; Furman et al., 1992; Padilla, 2015). These plutons are considered to preserve analogous plumbing systems to the central volcanoes active in Iceland today (Furman et al., 1992). Reyðarártindur is the oldest pluton in Southeast Iceland at 7.30 ± 0.06 Ma (Padilla, 2015), and has been conveniently incised by the Reyðará River, making it ideal for an in-depth study of the external and internal geometry of a shallow rift-zone magma plumbing system.In order to analyse mechanisms of magma emplacement, we have conducted detailed structural mapping of the pluton and its basaltic host rock using drone-based photogrammetry. To complement this, we have also extensively sampled and analysed the geochemistry and petrology of the pluton interior. An outline of the pluton is shown in Figure 1, highlighting that the pluton is NNW-SSE trending, which is in contrast to the NE-SW regional dyke trend. A total thickness of 500 m and a calculated volume of 1.5 km3 is exposed. While the pluton walls are steeply-dipping, the pluton roof is mostly flat. Deviations from the flat roof occur in the form of areas that are cut by steep dip-slip faults with displacements of up to 100 m. Roof faulting creates both structural highs (horsts) and lows (grabens, as well as a monoclinal structure) in the roof. Many of the faults are intruded by felsic dykes, some of them seem to have been the feeders of surface eruptions.An estimated 95% of the pluton volume is rhyolitic in composition, with 73-76 wt.% SiO2. Geochemically, the magma in the majority of the pluton is similar, but hand samples and thin sections show a large variety of textures. In the lower part of the exposure there is a zone of mingling and mixing between a matrix magma and several different types of silicic enclaves (Figure 1). The matrix magma is more mafic with an SiO2 content of 68-73 wt.% and the enclaves vary in nature with no systematic shape, size or aspect ratio. There are at least two types of enclaves, and the predominant type is a coarse grained trachydacite with 64-69 wt.% SiO2. These less evolved compositions are limited to a 1 km stretch of the riverbed in the centre of the pluton. Closer to the wall contacts (i.e. to the north and south of the mingling zone), the composition of the magma returns to that of the main magma body, as observed at higher elevations.Our poster aims to summarise our results and present interpretations of the magmatic processes preserved in the Reyðarártindur pluton. Our preliminary results indicate that the pluton was emplaced by a combination of floor subsidence and roof doming, and that the pluton structure was modified during further magma intrusion into, and eruption from, the pluton. Fig. 1 – Map of the Reyðarártindur Pluton, South-East Iceland. References Cargill, H., Hawkes, L., and Ledeboen, J. (1928). The major intrustions of South-Eastern Iceland. Quarterly Journal of the Geological Society of London 84, 505–539.Furman, T., Meyer, P. S., and Frey, F. (1992). Evolution of Icelandic central volcanoes: evidence from the Austurhorn intrusion, southeastern Iceland. Bulletin of Volcanology. 55, 45–62.Padilla, A. (2015). Elemental and isotopic geochemistry of crystal-melt systems: Elucidating the construction and evolution of silicic magmas in the shallow crust, using examples from southeast Iceland and southwest USA [PhD Dissertation: Vanderbilt University].
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| 45. |
- Rhodes, Emma, 1990-, et al.
(författare)
-
Rapid Assembly and Eruption of a Shallow Silicic Magma Reservoir, Reyðarártindur Pluton, Southeast Iceland
- 2021
-
Ingår i: Geochemistry Geophysics Geosystems. - : American Geophysical Union (AGU). - 1525-2027. ; 22:11
-
Tidskriftsartikel (refereegranskat)abstract
- Although it is widely accepted that shallow silicic magma reservoirs exist, and can feed eruptions, their dynamics and longevity are a topic of debate. Here, we use field mapping, geochemistry, 3D pluton reconstruction and a thermal model to investigate the assembly and eruptive history of the shallow Reyoarartindur Pluton, southeast Iceland. Primarily, the exposed pluton is constructed of a single rock unit, the Main Granite (69.9-77.7 wt.% SiO2). Two further units are locally exposed as enclaves at the base of the exposure, the Granite Enclaves (67.4-70.2 wt.% SiO2), and the Quartz Monzonite Enclaves (61.8-67.3 wt.% SiO2). Geochemically, the units are related and were likely derived from the same source reservoir. In 3D, the pluton has a shape characterized by flat roof segments that are vertically offset and a volume of >2.5 km(3). The pluton roof is intruded by dikes from the pluton, and in two locations displays depressions associated with large dikes. Within these particular dikes the rock is partially to wholly tuffisitic, and rock compositions range from quartz monzonite to granite. We interpret these zones as eruption-feeding conduits from the pluton. A lack of cooling contacts throughout the pluton indicates rapid magma emplacement and a thermal model calculates the top 75 m would have rheologically locked up within 1,000 years. Hence, we argue that the Reyoarartindur Pluton was an ephemeral part of the wider plumbing system that feeds a volcano, and that timeframes from emplacement to eruption were rapid.
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| 46. |
- Rhodes, Emma, 1990-, et al.
(författare)
-
Rapid formation and eruption of a silicic magma chamber
- 2022
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Shallow magmatic reservoirs have been identified at many volcanoes worldwide. However, questions still remain regarding their size, dynamics and longevity. The Reyðarártindur Pluton exposed in Southeast Iceland provides a superb example to investigate the above questions. Here, we use field mapping, sampling, geochemistry, 3D pluton shape modelling and a numerical thermal model to reconstruct the assembly and eruptive history of the shallow magma body.In 3D, the c. 2.5 km3 pluton has a castle-like shape characterised by flat roof segments that are vertically offset along steep faults. The exposed pluton is constructed largely of a single rock unit, the Main Granite (69.9 to 77.6 wt.% SiO2). Two additional units occur only as enclaves: the Granite Enclaves (67.4 to 70.2 wt.% SiO2), and the Quartz Monzonite Enclaves (61.8 to 67.3 wt.% SiO2). However, geochemistry clearly indicates that the units are related and hence were likely derived from the same source reservoir. In two locations, the pluton roof displays depressions associated with large dykes. Within these two dykes the rock is partially to wholly tuffisitic, and geochemical compositions range from quartz monzonite to granite. We interpret these dykes as eruption-feeding conduits from the pluton. Additionally, we speculate that the mingling of magmatic units with compositional ranges from quartz monzonite to granite within the conduits indicates that injection of new magma into the reservoir triggered eruption. Rapid pluton construction is indicated by ductile contacts between units in the pluton and a thermal model calculates the top 75 m would have rheologically locked up within 1000 years. Hence, we argue that the pluton was a short-lived part of the wider magmatic system that fed the associated volcano, and that timeframes from emplacement to eruption were limited to 1000 years.Rhodes, E. Barker, A. K. Burchardt, S. et al. (2021). Rapid assembly and eruption of a shallow silicic magma reservoir, Reyðarártindur Pluton, Southeast Iceland. G-Cubed. DOI: 10.1029/2021GC009999
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| 47. |
- Rhodes, Emma, 1990-, et al.
(författare)
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The plutonic-volcanic connection – Preliminary results from Reyðarártindur pluton, Iceland
- 2019
-
Ingår i: Subvolcanic Processes.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Reyðarártindur is a granophyre pluton exposed in East Iceland, which prior to this field season had not been mapped in detail. Dated at 7.30 ± 0.06 Ma, the ~ 15 km2 pluton was emplaced into the flat-lying basaltic lava flows of the Neogene rift zone and felsic volcanic deposits of the Lon Central Volcano (Padilla, 2015). The intrusion is the oldest of the South-East Iceland Intrusive Suite, and these plutons are interpreted to be the shallow plumbing systems of late Tertiary volcanic centres (Cargill et al., 1928; Furman et al., 1992; Padilla, 2015).Glacial erosion has carved a valley through the centre of Reyðarártindur, exposing cross sections of the roof, the pluton interior and overlying volcanic rocks likely associated to Reyðarártindur. These features make it an ideal study area of pluton-volcano connection. We have conducted field mapping, sampling and photogrammetry with the aim to investigate plutonic-volcanic-tectonic processes.The pluton is NNW-SSE trending, which is in contrast to the NE-SW regional dyke trend. While the pluton walls are steeply-dipping, the pluton roof is mostly flat but offset up to 100m by steep dip-slip faults. Many of these faults are intruded by felsic dykes, in some cases connecting the pluton to overlying volcanic rocks. Using photogrammetry, we have mapped the shallowly dipping basaltic host rock, the faults and dykes in the pluton roof. We will present first results on the shape of the magma body and the pluton roof structure. We will then discuss the implications of the roof structures and the pluton shape for the plutonic-volcanic connection and the evolution of the Reyðarártindur intrusion. ReferencesCargill, H., Hawkes, L., and Ledeboen, J. (1928). The major intrustions of South-Eastern Iceland. Q. J. Geol. Soc. London 84, 505–539.Furman, T., Meyer, P. S., and Frey, F. (1992). Evolution of Icelandic central volcanoes: evidence from the Austurhorn intrusion, southeastern Iceland. Bull. Volcanol. 55, 45–62. doi:10.1007/BF00301119.Padilla, A. (2015). Elemental and isotopic geochemistry of crystal-melt systems: Elucidating the construction and evolution of silicic magmas in the shallow crust, using examples from southeast Iceland and southwest USA [PhD Dissertation: Vanderbilt University].
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- Sahlström, Thomas, et al.
(författare)
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Bacteremia with ESBL-producing Enterobacterales is associated with IgG antibodies reacting with CTX-M-15 and/or CTX-M-27
- 2020
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Ingår i: International Journal of Medical Microbiology. - : Elsevier BV. - 1438-4221. ; 310:8
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The adaptive humoral immune response following clinical infection with extended spectrum beta-lactamase (ESBL)-producing Enterobacterales (EPE) has not been thoroughly investigated. The aim of this study was to investigate the presence of anti-CTX-M-15 and/or anti-CTX-M-27 IgG antibodies in bacteremia patients diagnosed with EPE compared to a control group consisting of patients suffering from bacteremia with third generation cephalosporin-susceptible Escherichia coli (3GCSE). Methods: Patientswith EPE (n = 59) or 3GCSE (n = 42) bacteremia were recruited in this case control study in the Skåne County (South of Sweden). Sera were collected 1–26 months after bacteremia. Enzyme-linked immunosorbent assay (ELISA) was used for detection of specific IgG antibodies directed against recombinant beta-lactamases CTX-M-15 and CTX-M-27. The beta-lactamase resistance genes of the corresponding EPE blood isolates were determined by DNA sequencing. Results: The majority (n = 47; 80 %) of the 59 EPE blood isolates carried blaCTX-M-15 or blaCTX-M-27 genes. IgG antibodies reacting to the corresponding CTX-M enzyme was seen in 28 % (13/47) of patients suffering from EPE-bacteremia, while antibodies were detected in only 9.5 % (4/42) of patients with 3GCSE (p = 0.03). Patients with EPE had a statistically significantly higher median Charlson comorbidity index and prevalence of renal disease (p = 0.01), compared to the 3GCSE control group. Conclusion: This study implies that EPE bacteremia can trigger production of IgG antibodies targeting ESBL. Further investigations are required to determine the functional role of anti-ESBL antibodies against EPE bacteremia.
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