| 1. |
- Aad, G, et al.
(författare)
-
- 2015
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swepub:Mat__t
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| 2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
- Murari, A., et al.
(författare)
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A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors
- 2024
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Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. In this work we report how, deploying innovative analysis methods on thousands of JET experiments covering the isotopic compositions from hydrogen to full tritium and including the major D-T campaign, the nature of the various forms of collapse is investigated in all phases of the discharges. An original approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.
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| 4. |
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Overview of the JET results
- 2015
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Romanelli, F, et al.
(författare)
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Overview of the JET results
- 2011
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 51:9
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Tidskriftsartikel (refereegranskat)abstract
- Since the last IAEA Conference JET has been in operation for one year with a programmatic focus on the qualification of ITER operating scenarios, the consolidation of ITER design choices and preparation for plasma operation with the ITER-like wall presently being installed in JET. Good progress has been achieved, including stationary ELMy H-mode operation at 4.5 MA. The high confinement hybrid scenario has been extended to high triangularity, lower ρ*and to pulse lengths comparable to the resistive time. The steady-state scenario has also been extended to lower ρ*and ν*and optimized to simultaneously achieve, under stationary conditions, ITER-like values of all other relevant normalized parameters. A dedicated helium campaign has allowed key aspects of plasma control and H-mode operation for the ITER non-activated phase to be evaluated. Effective sawtooth control by fast ions has been demonstrated with3He minority ICRH, a scenario with negligible minority current drive. Edge localized mode (ELM) control studies using external n = 1 and n = 2 perturbation fields have found a resonance effect in ELM frequency for specific q95values. Complete ELM suppression has, however, not been observed, even with an edge Chirikov parameter larger than 1. Pellet ELM pacing has been demonstrated and the minimum pellet size needed to trigger an ELM has been estimated. For both natural and mitigated ELMs a broadening of the divertor ELM-wetted area with increasing ELM size has been found. In disruption studies with massive gas injection up to 50% of the thermal energy could be radiated before, and 20% during, the thermal quench. Halo currents could be reduced by 60% and, using argon/deuterium and neon/deuterium gas mixtures, runaway electron generation could be avoided. Most objectives of the ITER-like ICRH antenna have been demonstrated; matching with closely packed straps, ELM resilience, scattering matrix arc detection and operation at high power density (6.2 MW m-2) and antenna strap voltages (42 kV). Coupling measurements are in very good agreement with TOPICA modelling. © 2011 IAEA, Vienna.
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| 10. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 11. |
- Barucca, G., et al.
(författare)
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The potential of Λ and Ξ- studies with PANDA at FAIR
- 2021
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Tidskriftsartikel (refereegranskat)abstract
- The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: p¯ p→ Λ¯ Λ and p¯ p→ Ξ¯ +Ξ-. The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.
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| 12. |
- Bouyoucef, S E, et al.
(författare)
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Poster Session 2 : Monday 4 May 2015, 08
- 2015
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Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Tidskriftsartikel (refereegranskat)
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| 13. |
- Barucca, G., et al.
(författare)
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Study of excited Ξ baryons with the P¯ ANDA detector
- 2021
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Tidskriftsartikel (refereegranskat)abstract
- The study of baryon excitation spectra provides insight into the inner structure of baryons. So far, most of the world-wide efforts have been directed towards N∗ and Δ spectroscopy. Nevertheless, the study of the double and triple strange baryon spectrum provides independent information to the N∗ and Δ spectra. The future antiproton experiment P¯ANDA will provide direct access to final states containing a Ξ¯ Ξ pair, for which production cross sections up to μb are expected in p¯p reactions. With a luminosity of L= 10 31 cm- 2 s- 1 in the first phase of the experiment, the expected cross sections correspond to a production rate of ∼106events/day. With a nearly 4 π detector acceptance, P¯ANDA will thus be a hyperon factory. In this study, reactions of the type p¯p → Ξ¯ +Ξ∗ - as well as p¯p → Ξ¯ ∗ +Ξ- with various decay modes are investigated. For the exclusive reconstruction of the signal events a full decay tree fit is used, resulting in reconstruction efficiencies between 3 and 5%. This allows high statistics data to be collected within a few weeks of data taking.
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| 14. |
- Abe, K., et al.
(författare)
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J-PARC Neutrino Beamline Upgrade Technical Design Report
- 2019
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Rapport (refereegranskat)abstract
- In this document, technical details of the upgrade plan of the J-PARC neutrino beamline for the extension of the T2K experiment are described. T2K has proposed to accumulate data corresponding to 2×1022 protons-on-target in the next decade, aiming at an initial observation of CP violation with 3σ or higher significance in the case of maximal CP violation. Methods to increase the neutrino beam intensity, which are necessary to achieve the proposed data increase, are described.
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| 15. |
- Purdue, Mark P, et al.
(författare)
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Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:1, s. 60-65
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 × 10⁻¹⁴). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 × 10⁻⁸). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.
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| 16. |
- Aghion, S., et al.
(författare)
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A moiré deflectometer for antimatter
- 2014
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful extension of a tool from atom optics—the moiré deflectometer—for a measurement of the acceleration of slow antiprotons. The setup consists of two identical transmission gratings and a spatially resolving emulsion detector for antiproton annihilations. Absolute referencing of the observed antimatter pattern with a photon pattern experiencing no deflection allows the direct inference of forces present. The concept is also straightforwardly applicable to antihydrogen measurements as pursued by the AEgIS collaboration. The combination of these very different techniques from high energy and atomic physics opens a very promising route to the direct detection of the gravitational acceleration of neutral antimatter.
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| 17. |
- Airila, M. I., et al.
(författare)
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ERO modelling of local deposition of injected C-13 tracer at the outer divertor of JET
- 2009
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Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; T138, s. 014021-
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Tidskriftsartikel (refereegranskat)abstract
- The 2004 tracer experiment of JET with the injection of (CH4)-C-13 into H-mode plasma at the outer divertor has been modelled with the Monte Carlo impurity transport code ERO. EDGE2D solutions for inter-ELM and ELM-peak phases were used as plasma backgrounds. Local two-dimensional (2D) deposition patterns at the vertical outer divertor target plate were obtained for comparison with post-mortem surface analyses. ERO also provides emission profiles for comparison with radially resolved spectroscopic measurements. Modelling indicates that enhanced re-erosion of deposited carbon layers is essential in explaining the amount of local deposition. Assuming negligible effective sticking of hydrocarbons, the measured local deposition of 20-34% is reproduced if re-erosion of deposits is enhanced by a factor of 2.5-7 compared to graphite erosion. If deposits are treated like the substrate, the modelled deposition is 55%. Deposition measurements at the shadowed area around injectors can be well explained by assuming negligible re-erosion but similar sticking behaviour there as on plasma-wetted surfaces.
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| 18. |
- Ariga, T., et al.
(författare)
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Measuring GBAR with emulsion detector
- 2014
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Ingår i: International Journal of Modern Physics, Conference Series. - : World Scientific. - 2010-1945. ; 30
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Tidskriftsartikel (refereegranskat)
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| 19. |
- Litnovsky, A., et al.
(författare)
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Optimization of tungsten castellated structures for the ITER divertor
- 2015
-
Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 463, s. 174-179
-
Tidskriftsartikel (refereegranskat)abstract
- In ITER, the plasma-facing components (PFCs) of the first wall and the divertor armor will be castellated to improve their thermo-mechanical stability and to limit forces due to induced currents. The fuel accumulation in the gaps may significantly contribute to the in-vessel fuel inventory. Castellation shaping may be the most straightforward way to minimize the fuel inventory and to alleviate the thermal loads onto castellations. A new castellation shape was proposed and comparative modeling of conventional (rectangular) and shaped castellation was performed for ITER conditions. Shaped castellation was predicted to be capable to operate under stationary heat load of 20 MW/m(2). An 11-fold decrease of beryllium (Be) content in the gaps of the shaped cells alone with a 7-fold decrease of carbon content was predicted. In order to validate the predictive capabilities of modeling tools used for ITER conditions, the dedicated modeling with the same codes was made for existing tokamaks and benchmarked with the results of multi-machine experiments. For the castellations exposed in TEXTOR and DIII-D, the carbon amount in the gaps of shaped cells was 1.9-2.3 times smaller than that of rectangular ones. Modeling for TEXTOR conditions yielded to 1.5-fold decrease of carbon content in the gaps of shaped castellation outlining fair agreement with the experiment. At the same time, a number of processes, like enhanced erosion of molten layer yet need to be implemented in the codes in order to increase the accuracy of predictions for ITER.
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| 20. |
- Bonvicini, V., et al.
(författare)
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New concepts in silicon calorimetry for space experiments
- 2004
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 518:1-2, s. 186-187
-
Tidskriftsartikel (refereegranskat)abstract
- In the framework of the INFN R&D project CASIS, we have designed a new double-sided silicon strip detector with parallel strips, optimised for calorimetry. The idea is to read out p and n strips with two types of electronics, having different sensitivities and ranges, in order to increase the overall dynamic range by covering different signal regions. We present results from a test beam we performed at TSL (Uppsala, Sweden) with N, O and Ne ions with energies above 40 MeV/n. The design of a new front-end integrated circuit, with ultra-large dynamic range (more than 10,000 MIP) is under way and the first prototypes will be produced by the end of 2003.
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| 21. |
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| 22. |
- Litnovsky, A., et al.
(författare)
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Overview of material migration and mixing, fuel retention and cleaning of ITER-like castellated structures in TEXTOR
- 2011
-
Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 415:1, s. S289-S292
-
Tidskriftsartikel (refereegranskat)abstract
- Plasma-facing components (PFCs) in ITER will be castellated by splitting them into small-size blocks to maintain the thermo-mechanical stability. However, there are concerns in particular on retention of codeposited radioactive fuel in the gaps. An R&D program is underway in TEXTOR addressing this acute issue of castellation. Material migration and fuel inventory are investigated using long- and short-term discharge-resolved experiments with castellated structures in TEXTOR. Significant impurity transport to the gaps was detected and results were in part quantitatively reproduced with 3D-GAPS code. Deposits containing up to 70 at.% of tungsten on the gap areas closest to the plasma were detected in recent experiments. Deposition in the gaps accompanied by metal mixing demand for development of effective cleaning techniques. In experiments with ITER-like castellation, the gaps were cleaned from carbonaceous deposits using oxygen plasmas at 350 degrees C. This contribution contains an overview of experimental and modeling results along with recommendations for PFCs in ITER.
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| 23. |
- Lokachari, Nitin, et al.
(författare)
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A comprehensive experimental and kinetic modeling study of di-isobutylene isomers : Part 2
- 2023
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Ingår i: Combustion and Flame. - : Elsevier BV. - 0010-2180. ; 251
-
Tidskriftsartikel (refereegranskat)abstract
- A wide variety of high temperature experimental data obtained in this study complement the data on the oxidation of the two di-isobutylene isomers presented in Part I and offers a basis for an extensive validation of the kinetic model developed in this study. Due to the increasing importance of unimolecular decomposition reactions in high-temperature combustion, we have investigated the di-isobutylene isomers in high dilution utilizing a pyrolysis microflow reactor and detected radical intermediates and stable products using vacuum ultraviolet (VUV) synchrotron radiation and photoelectron photoion coincidence (PEPICO) spectroscopy. Additional speciation data at oxidative conditions were also recorded utilizing a plug flow reactor at atmospheric pressure in the temperature range 725–1150 K at equivalence ratios of 1.0 and 3.0 and at residence times of 0.35 s and 0.22 s, respectively. Combustion products were analyzed using gas chromatography (GC) and mass spectrometry (MS). Ignition delay time measurements for di-isobutylene were performed at pressures of 15 and 30 bar at equivalence ratios of 0.5, 1.0, and 2.0 diluted in ‘air’ in the temperature range 900–1400 K using a high-pressure shock-tube facility. New measurements of the laminar burning velocities of di-isobutylene/air flames are also presented. The experiments were performed using the heat flux method at atmospheric pressure and initial temperatures of 298–358 K. Moreover, data consistency was assessed with the help of analysis of the temperature and pressure dependencies of laminar burning velocity measurements, which was interpreted using an empirical power-law expression. Electronic structure calculations were performed to compute the energy barriers to the formation of many of the product species formed. The predictions of the present mechanism were found to be in adequate agreement with the wide variety of experimental measurements performed.
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| 24. |
- Matveev, V. V., et al.
(författare)
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Investigation of Melts of Polybutylcarbosilane Dendrimers by 1H NMR Spectroscopy
- 2017
-
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7:1
-
Tidskriftsartikel (refereegranskat)abstract
- Melts of polybutylcarbosilane (PBC) dendrimers from third (G3) up to sixth (G6) generations are investigated by 1H NMR spectroscopy in a wide temperature range up to 493 K. At room temperature, NMR spectra of G3-G5 dendrimers exhibit resolved, solution-like spectra ("liquid" phase). In contrast, the spectrum of the G6 dendrimer is characterized by a single unresolved broad line at whole temperature range, which supports the presence of an anomalous phase state of G6 at temperatures higher than glass transition temperature. For the first time, an unexpected transition of G5 dendrimer from a molecular liquid state to an anomalous state/phase upon temperature increase has been detected using NMR data. Specifically, an additional wide background line appears in the G5 spectrum above 473 K, and this line corresponds to a G5 state characterized by restricted molecular mobility, i.e., a state similar to the "anomalous" phase of G6 melt. The fraction of the G5 dendrimers in "anomalous" phase at 493 K is approximately 40%. Analysis of the spectral shapes suggests that changes in the G5 dendrimers are reversible with temperature.
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| 25. |
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| 26. |
- Rubel, Marek, et al.
(författare)
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Fuel inventory and deposition in castellated structures in JET-ILW
- 2017
-
Ingår i: Nuclear Fusion. - : Institute of Physics Publishing. - 0029-5515 .- 1741-4326. ; 57:6
-
Tidskriftsartikel (refereegranskat)abstract
- Since 2011 the JET tokamak has been operated with a metal ITER-like wall (JET-ILW) including castellated beryllium limiters and lamellae-type bulk tungsten tiles in the divertor. This has allowed for a large scale test of castellated plasma-facing components (PFC). Procedures for sectioning the limiters into single blocks of castellation have been developed. This facilitated morphology studies of morphology of surfaces inside the grooves for limiters after experimental campaigns 2011-2012 and 2013-2014. The deposition in the 0.4-0.5 mm wide grooves of the castellation is 'shallow'. It reaches 1-2 mm into the 12 mm deep gap. Deuterium concentrations are small (mostly below 1 × 1018 cm-2). The estimated total amount of deuterium in all the castellated limiters does not exceed the inventory of the plasma-facing surfaces (PFS) of the limiters. There are only traces of Ni, Cr and Fe deposited in the castellation gaps. The same applies to the carbon content. Also low deposition of D, Be and C has been measured on the sides of the bulk tungsten lamellae pieces. Modelling clearly reflects: (a) a sharp decrease in the measured deposition profiles and(b) an increase in deposition with the gap width. Both experimental and modelling data give a strong indication and information to ITER that narrow gaps in the castellated PFC are essential. X-ray diffraction on PFS has clearly shown two distinct composition patterns: Be with an admixture of Be-W intermetallic compounds (e.g. Be22W) in the deposition zone, whilst only pure Be has been detected in the erosion zone. The lack of compound formation in the erosion zone indicates that no distinct changes in the thermo-mechanical properties of the Be PFC might be expected.
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| 27. |
- Rülke, A., et al.
(författare)
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The antarctic regional GPS network densification : Status and results
- 2016
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Ingår i: IAG 150 Years proceedings of the 2013 IAG Scientific Assembly, Postdam, Germany, 1-6 September, 2013. - Cham : Springer. - 9783319246031 ; , s. 133-139
-
Konferensbidrag (refereegranskat)abstract
- We report on the activities related to the IAG Subcommission 1.3f “Regional Reference Frame for Antarctica”. Campaign-style GPS observations have been carried out since 1995. Based on the Bernese GNSS Software the latest analysis yields results for about 30 stations aligned to the terrestrial reference frame solution IGS08. The obtained station motions are discussed in the context of plate kinematics and glacial-isostatic adjustment. It is demonstrated that the activities are a valuable contribution both to the ITRF densification in Antarctica and to geodynamic research.
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| 28. |
- Ruzek, Daniel, et al.
(författare)
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Tick-borne encephalitis in Europe and Russia : review of pathogenesis, clinical features, therapy, and vaccines
- 2019
-
Ingår i: Antiviral Research. - : Elsevier. - 0166-3542 .- 1872-9096. ; 164, s. 23-51
-
Forskningsöversikt (refereegranskat)abstract
- Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV) infection which is often limited to a febrile illness, but may lead to very aggressive downstream neurological manifestations. The disease is prevalent in forested areas of Europe and northeastern Asia, and is typically caused by infection involving one of three TBEV subtypes, namely the European (TBEV-Eu), the Siberian (TBEV-Sib), or the Far Eastern (TBEV-FE) subtypes. In addition to the three main TBEV subtypes, two other subtypes; i.e., the Baikalian (TBEV-Bkl) and the Himalayan subtype (TBEV-Him), have been described recently. In Europe, TBEV-Eu infection usually results in only mild TBE associated with a mortality rate of < 2%. TBEV-Sib infection also results in a generally mild TBE associated with a non-paralytic febrile form of encephalitis, although there is a tendency towards persistent TBE caused by chronic viral infection. TBE-FE infection is considered to induce the most severe forms of TBE. Importantly though, viral subtype is not the sole determinant of TBE severity; both mild and severe cases of TBE are in fact associated with infection by any of the subtypes. In keeping with this observation, the overall TBE mortality rate in Russia is similar to 2%, in spite of the fact that TBEV-Sib and TBEV-FE subtypes appear to be inducers of more severe TBE than TBEV-Eu. On the other hand, TBEV-Sib and TBEV-FE subtype infections in Russia are associated with essentially unique forms of TBE rarely seen elsewhere if at all, such as the hemorrhagic and chronic (progressive) forms of the disease. For post-exposure prophylaxis and TBE treatment in Russia and Kazakhstan, a specific anti-TBEV immunoglobulin is currently used with well-documented efficacy, but the use of specific TBEV immunoglobulins has been discontinued in Europe due to concerns regarding antibody-enhanced disease in naive individuals. Therefore, new treatments are essential. This review summarizes available data on the pathogenesis and clinical features of TBE, plus different vaccine preparations available in Europe and Russia. In addition, new treatment possibilities, including small molecule drugs and experimental immunotherapies are reviewed. The authors caution that their descriptions of approved or experimental therapies should not be considered to be recommendations for patient care.
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| 29. |
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