| 1. |
- Bombarda, F., et al.
(författare)
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Runaway electron beam control
- 2019
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Tidskriftsartikel (refereegranskat)
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| 2. |
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- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
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Forskningsöversikt (refereegranskat)
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| 11. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 19. |
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Overview of the JET results
- 2015
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
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Tidskriftsartikel (refereegranskat)
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| 20. |
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| 23. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 24. |
- Arndt, D. S., et al.
(författare)
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State of the Climate in 2016
- 2017
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 98:8, s. S1-S280
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Tidskriftsartikel (refereegranskat)abstract
- In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 +/- 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 +/- 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Nino events since at least 1950 dissipated in spring, and a weak La Nina evolved later in the year. Owing at least in part to the combination of El Nino conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44 degrees C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0 degrees C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8 degrees C, representing a 3.5 degrees C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 average. The September 2016 Arctic sea ice minimum extent tied with 2007 for the second lowest value on record, 33% lower than the 1981-2010 average. Arctic sea ice cover remains relatively young and thin, making it vulnerable to continued extensive melt. The mass of the Greenland Ice Sheet, which has the capacity to contribute similar to 7 m to sea level rise, reached a record low value. The onset of its surface melt was the second earliest, after 2012, in the 37-year satellite record. Sea surface temperature was record high at the global scale, surpassing the previous record of 2015 by about 0.01 degrees C. The global sea surface temperature trend for the 21st century-to-date of +0.162 degrees C decade(-1) is much higher than the longer term 1950-2016 trend of +0.100 degrees C decade(-1). Global annual mean sea level also reached a new record high, marking the sixth consecutive year of increase. Global annual ocean heat content saw a slight drop compared to the record high in 2015. Alpine glacier retreat continued around the globe, and preliminary data indicate that 2016 is the 37th consecutive year of negative annual mass balance. Across the Northern Hemisphere, snow cover for each month from February to June was among its four least extensive in the 47-year satellite record. Continuing a pattern below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska and at the Canadian observatory on northernmost Ellesmere Island. In the Antarctic, record low monthly surface pressures were broken at many stations, with the southern annular mode setting record high index values in March and June. Monthly high surface pressure records for August and November were set at several stations. During this period, record low daily and monthly sea ice extents were observed, with the November mean sea ice extent more than 5 standard deviations below the 1981-2010 average. These record low sea ice values contrast sharply with the record high values observed during 2012-14. Over the region, springtime Antarctic stratospheric ozone depletion was less severe relative to the 1991-2006 average, but ozone levels were still low compared to pre-1990 levels. Closer to the equator, 93 named tropical storms were observed during 2016, above the 1981-2010 average of 82, but fewer than the 101 storms recorded in 2015. Three basins-the North Atlantic, and eastern and western North Pacific-experienced above-normal activity in 2016. The Australian basin recorded its least active season since the beginning of the satellite era in 1970. Overall, four tropical cyclones reached the Saffir-Simpson category 5 intensity level. The strong El Nino at the beginning of the year that transitioned to a weak La Nina contributed to enhanced precipitation variability around the world. Wet conditions were observed throughout the year across southern South America, causing repeated heavy flooding in Argentina, Paraguay, and Uruguay. Wetter-than-usual conditions were also observed for eastern Europe and central Asia, alleviating the drought conditions of 2014 and 2015 in southern Russia. In the United States, California had its first wetter-than-average year since 2012, after being plagued by drought for several years. Even so, the area covered by drought in 2016 at the global scale was among the largest in the post-1950 record. For each month, at least 12% of land surfaces experienced severe drought conditions or worse, the longest such stretch in the record. In northeastern Brazil, drought conditions were observed for the fifth consecutive year, making this the longest drought on record in the region. Dry conditions were also observed in western Bolivia and Peru; it was Bolivia's worst drought in the past 25 years. In May, with abnormally warm and dry conditions already prevailing over western Canada for about a year, the human-induced Fort McMurray wildfire burned nearly 590000 hectares and became the costliest disaster in Canadian history, with $3 billion (U.S. dollars) in insured losses.
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| 25. |
- Arndt, D. S., et al.
(författare)
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STATE OF THE CLIMATE IN 2017
- 2018
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 99:8, s. S1-S310
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Forskningsöversikt (refereegranskat)
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| 26. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 27. |
- Brezinsek, S., et al.
(författare)
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Beryllium migration in JET ITER-like wall plasmas
- 2015
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:6
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Tidskriftsartikel (refereegranskat)abstract
- JET is used as a test bed for ITER, to investigate beryllium migration which connects the lifetime of first-wall components under erosion with tokamak safety, in relation to long-term fuel retention. The (i) limiter and the (ii) divertor configurations have been studied in JET-ILW (JET with a Be first wall and W divertor), and compared with those for the former JET-C (JET with carbon-based plasma-facing components (PFCs)). (i) For the limiter configuration, the Be gross erosion at the contact point was determined in situ by spectroscopy as between 4% (E-in = 35 eV) and more than 100%, caused by Be self-sputtering (E-in = 200 eV). Chemically assisted physical sputtering via BeD release has been identified to contribute to the effective Be sputtering yield, i.e. at E-in = 75 eV, erosion was enhanced by about 1/3 with respect to the bare physical sputtering case. An effective gross yield of 10% is on average representative for limiter plasma conditions, whereas a factor of 2 difference between the gross erosion and net erosion, determined by post-mortem analysis, was found. The primary impurity source in the limiter configuration in JET-ILW is only 25% higher (in weight) than that for the JET-C case. The main fraction of eroded Be stays within the main chamber. (ii) For the divertor configuration, neutral Be and BeD from physically and chemically assisted physical sputtering by charge exchange neutrals and residual ion flux at the recessed wall enter the plasma, ionize and are transported by scrape-off layer flows towards the inner divertor where significant net deposition takes place. The amount of Be eroded at the first wall (21 g) and the Be amount deposited in the inner divertor (28 g) are in fair agreement, though the balancing is as yet incomplete due to the limited analysis of PFCs. The primary impurity source in the JET-ILW is a factor of 5.3 less in comparison with that for JET-C, resulting in lower divertor material deposition, by more than one order of magnitude. Within the divertor, Be performs far fewer re-erosion and transport steps than C due to an energetic threshold for Be sputtering, and inhibits as a result of this the transport to the divertor floor and the pump duct entrance. The target plates in the JET-ILW inner divertor represent at the strike line a permanent net erosion zone, in contrast to the net deposition zone in JET-C with thick carbon deposits on the CFC (carbon-fibre composite) plates. The Be migration identified is consistent with the observed low long-term fuel retention and dust production with the JET-ILW.
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| 28. |
- Holl, Matthias, 1986, et al.
(författare)
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Border of the island of inversion: Unbound states in Ne-29
- 2022
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 105:3
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Tidskriftsartikel (refereegranskat)abstract
- The nucleus Ne-29 is situated at the border of the island of inversion. Despite significant efforts, no bound low-lying intruder f(7/2) state, which would place Ne-29 firmly inside the island of inversion, has yet been observed. Here, the first investigation of unbound states of Ne-29 is reported. The states were populated in Ne-30(p, pn) and Na-30(p, 2p) reactions at a beam energy of around 230 MeV/nucleon, and analyzed in terms of their resonance properties, partial cross sections, and momentum distributions. The momentum distributions are compared to calculations using the eikonal, direct reaction model, allowing assignments for the observed states. The lowest lying resonance at an excitation energy of 1.48(4) MeV shows clear signs of a significant l = 3 component, giving first evidence for f(7/2) single particle strength in Ne-29. The excitation energies and strengths of the observed states are compared to shell-model calculations using the SDPF-U-MIX interaction.
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| 29. |
- Kowal-Bielecka, Otylia, et al.
(författare)
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Update of EULAR recommendations for the treatment of systemic sclerosis
- 2017
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 76, s. 1327-1339
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by the pan-European patient association for SSc (Federation of European Scleroderma Associations (FESCA)), a clinical epidemiologist and 2 research fellows. All centres from the EULAR Scleroderma Trials and Research group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in 16 recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud's phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis and gastrointestinal involvement. Compared with the 2009 recommendations, the 2016 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressive SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. These updated data-derived and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc.
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| 30. |
- Squicciarini, V., et al.
(författare)
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A scaled-up planetary system around a supernova progenitor
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 664
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Tidskriftsartikel (refereegranskat)abstract
- Context. Virtually all known exoplanets reside around stars with M < 2.3 M⊙ either due to the rapid evaporation of the protostellar disks or to selection effects impeding detections around more massive stellar hosts.Aims. To clarify if this dearth of planets is real or a selection effect, we launched the planet-hunting B-star Exoplanet Abundance STudy (BEAST) survey targeting B stars (M > 2.4 M⊙) in the young (5-20 Myr) Scorpius-Centaurus association by means of the high-contrast spectro-imager SPHERE at the Very Large Telescope.Methods. In this paper we present the analysis of high-contrast images of the massive (M - 9 M⊙) star μ2 Sco obtained within BEAST. We carefully examined the properties of this star, combining data from Gaia and from the literature, and used state-of-the-art algorithms for the reduction and analysis of our observations.Results. Based on kinematic information, we found that μ2 Sco is a member of a small group which we label Eastern Lower Scorpius within the Scorpius-Centaurus association. We were thus able to constrain its distance, refining in turn the precision on stellar parameters. Around this star we identify a robustly detected substellar companion (14.4 ± 0.8 MJ)at a projected separation of 290 ± 10 au, and a probable second similar object (18.5 ± 1.5 MJ) at 21 ± 1 au. The planet-to-star mass ratios of these objects are similar to that of Jupiter to the Sun, and the flux they receive from the star is similar to those of Jupiter and Mercury, respectively.Conclusions. The robust and the probable companions of μ2 Sco are naturally added to the giant 10.9 MJ planet recently discovered by BEAST around the binary b Cen system. While these objects are slightly more massive than the deuterium burning limit, their properties are similar to those of giant planets around less massive stars and they are better reproduced by assuming that they formed under a planet-like, rather than a star-like scenario. Irrespective of the (needed) confirmation of the inner companion, μ2 Sco is the first star that would end its life as a supernova that hosts such a system. The tentative high frequency of BEAST discoveries is unexpected, and it shows that systems with giant planets or small-mass brown dwarfs can form around B stars. When putting this finding in the context of core accretion and gravitational instability formation scenarios, we conclude that the current modeling of both mechanisms is not able to produce this kind of companion. The completion of BEAST will pave the way for the first time to an extension of these models to intermediate and massive stars.
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| 31. |
- Widdowson, A., et al.
(författare)
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Overview of fuel inventory in JET with the ITER-like wall
- 2017
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Ingår i: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:8
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Tidskriftsartikel (refereegranskat)abstract
- Post mortem analyses of JET ITER-Like-Wall tiles and passive diagnostics have been completed after each of the first two campaigns (ILW-1 and ILW-2). They show that the global fuel inventory is still dominated by co-deposition; hence plasma parameters and sputtering processes affecting material migration influence the distribution of retained fuel. In particular, differences between results from the two campaigns may be attributed to a greater proportion of pulses run with strike points in the divertor corners, and having about 300 discharges in hydrogen at the end of ILW-2. Recessed and remote areas can contribute to fuel retention due to the larger areas involved, e.g. recessed main chamber walls, gaps in castellated Be main chamber tiles and material migration to remote divertor areas. The fuel retention and material migration due to the bulk W Tile 5 during ILW-1 are presented. Overall these tiles account for only a small percentage of the global accountancy for ILW-1.
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| 32. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 33. |
- Coad, J. P., et al.
(författare)
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Material migration and fuel retention studies during the JET carbon divertor campaigns
- 2019
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Ingår i: Fusion engineering and design. - : Elsevier BV. - 0920-3796 .- 1873-7196. ; 138, s. 78-108
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Tidskriftsartikel (refereegranskat)abstract
- The first divertor was installed in the JET machine between 1992 and 1994 and was operated with carbon tiles and then beryllium tiles in 1994-5. Post-mortem studies after these first experiments demonstrated that most of the impurities deposited in the divertor originate in the main chamber, and that asymmetric deposition patterns generally favouring the inner divertor region result from drift in the scrape-off layer. A new monolithic divertor structure was installed in 1996 which produced heavy deposition at shadowed areas in the inner divertor corner, which is where the majority of the tritium was trapped by co-deposition during the deuterium-tritium experiment in 1997. Different divertor geometries have been tested since such as the Gas-Box and High-Delta divertors; a principle objective has been to predict plasma behaviour, transport and tritium retention in ITER. Transport modelling experiments were carried out at the end of four campaigns by puffing C-13-labelled methane, and a range of diagnostics such as quartz-microbalance and rotating collectors have been installed to add time resolution to the post-mortem analyses. The study of material migration after D-D and D-T campaigns clearly revealed important consequences of fuel retention in the presence of carbon walls. They gave a strong impulse to make a fundamental change of wall materials. In 2010 the carbon divertor and wall tiles were removed and replaced with tiles with Be or W surfaces for the ITER-Like Wall Project.
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| 34. |
- Gowda, Naveen K. C., et al.
(författare)
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Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70
- 2018
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Ingår i: Nature Structural & Molecular Biology. - : Springer Science and Business Media LLC. - 1545-9993 .- 1545-9985. ; 25:1, s. 83-
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Tidskriftsartikel (refereegranskat)abstract
- Protein quality control depends on the tight regulation of interactions between molecular chaperones and polypeptide substrates. Substrate release from the chaperone Hsp70 is triggered by nucleotide-exchange factors (NEFs) that control folding and degradation fates via poorly understood mechanisms. We found that the armadillo-type NEFs budding yeast Fes1 and its human homolog HspBP1 employ flexible N-terminal release domains (RDs) with substrate-mimicking properties to ensure the efficient release of persistent substrates from Hsp70. The RD contacts the substrate-binding domain of the chaperone, competes with peptide substrate for binding and is essential for proper function in yeast and mammalian cells. Thus, the armadillo domain engages Hsp70 to trigger nucleotide exchange, whereas the RD safeguards the release of substrates. Our findings provide fundamental mechanistic insight into the functional specialization of Hsp70 NEFs and have implications for the understanding of proteostasis-related disorders, including Marinesco-Sjögren syndrome.
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| 35. |
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| 36. |
- Gratton, R., et al.
(författare)
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Investigating three Sirius-like systems with SPHERE
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 646
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Tidskriftsartikel (refereegranskat)abstract
- Context. Sirius-like systems are relatively wide binaries with a separation from a few to hundreds of au; they are composed of a white dwarf (WD) and a companion of a spectral type earlier than M0. Here we consider main sequence (MS) companions, where the WD progenitor evolves in isolation, but its wind during the former asymptotic giant branch (AGB) phase pollutes the companion surface and transfers some angular momentum. They are rich laboratories to constrain stellar models and binary evolution.Aims. Within the SpHere INfrared survey for Exoplanet survey that uses the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument at the Very Large Telescope, our goal is to acquire high contrast multi-epoch observations of three Sirius-like systems, HD 2133, HD 114174, and CD-56 7708 and to combine this data with archive high resolution spectra of the primaries, TESS archive, and literature data.Methods. These WDs are easy targets for SPHERE and were used as spectrophotometric standards. We performed very accurate abundance analyses for the MS stars using methods considered for solar analogs. Whenever possible, WD parameters and orbits were obtained using Monte Carlo Markov chain methods.Results. We found brighter J and K magnitudes for HD 114174B than obtained previously and extended the photometry down to 0.95 μm. Our new data indicate a higher temperature and then shorter cooling age (5.57 ± 0.02 Gyr) and larger mass (0.75 ± 0.03 M⊙) for this WD than previously assumed. Together with the oldest age for the MS star connected to the use of the Gaia DR2 distance, this solved the discrepancy previously found with the age of the MS star. The two other WDs are less massive, indicating progenitors of ∼1.3 M⊙ and 1.5 − 1.8 M⊙ for HD 2133B and CD-56 7708B, respectively. In spite of the rather long periods, we were able to derive useful constraints on the orbit for HD 114174 and CD-56 7708. They are both seen close to edge-on, which is in agreement with the inclination of the MS stars that are obtained coupling the rotational periods, stellar radii, and the projected rotational velocity from spectroscopy. The composition of the MS stars agrees fairly well with expectations from pollution by the AGB progenitors of the WDs: HD 2133A has a small enrichment of n-capture elements, which is as expected for pollution by an AGB star with an initial mass < 1.5 M⊙; CD-56 7708A is a previously unrecognized mild Ba-star, which is also expected due to pollution by an AGB star with an initial mass in the range of 1.5 − 3.0 M⊙; and HD 114174 has a very moderate excess of n-capture elements, which is in agreement with the expectation for a massive AGB star to have an initial mass > 3.0 M⊙.Conclusions. On the other hand, none of these stars show the excesses of C that are expected to go along with those of n-capture elements. This might be related to the fact that these stars are at the edges of the mass range where we expect nucleosynthesis related to thermal pulses. More work, both theoretical and observational, is required to better understand this issue.
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| 37. |
- Heinola, K., et al.
(författare)
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Long-term fuel retention in JET ITER-like wall
- 2016
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Ingår i: Physica Scripta. - : Institute of Physics Publishing (IOPP). - 0031-8949 .- 1402-4896. ; T167
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Tidskriftsartikel (refereegranskat)abstract
- Post-mortem studies with ion beam analysis, thermal desorption, and secondary ion mass spectrometry have been applied for investigating the long-term fuel retention in the JET ITERlike wall components. The retention takes place via implantation and co-deposition, and the highest retention values were found to correlate with the thickness of the deposited impurity layers. From the total amount of retained D fuel over half was detected in the divertor region. The majority of the retained D is on the top surface of the inner divertor, whereas the least retention was measured in the main chamber on the mid-plane of the inner wall limiter. The recessed areas of the inner wall showed significant contribution to the main chamber total retention. Thermal desorption spectroscopy analysis revealed the energetic T from DD reactions being implanted in the divertor. The total T inventory was assessed to be >0.3 mg.
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| 38. |
- Janson, Markus, et al.
(författare)
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A wide-orbit giant planet in the high-mass b Centauri binary system
- 2021
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 600:7888
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Tidskriftsartikel (refereegranskat)abstract
- Planet formation occurs around a wide range of stellar masses and stellar system architectures1. An improved understanding of the formation process can be achieved by studying it across the full parameter space, particularly towards the extremes. Earlier studies of planets in close-in orbits around high-mass stars have revealed an increase in giant planet frequency with increasing stellar mass2 until a turnover point at 1.9 solar masses (M⊙), above which the frequency rapidly decreases3. This could potentially imply that planet formation is impeded around more massive stars, and that giant planets around stars exceeding 3 M⊙ may be rare or non-existent. However, the methods used to detect planets in small orbits are insensitive to planets in wide orbits. Here we demonstrate the existence of a planet at 560 times the Sun–Earth distance from the 6- to 10-M⊙ binary b Centauri through direct imaging. The planet-to-star mass ratio of 0.10–0.17% is similar to the Jupiter–Sun ratio, but the separation of the detected planet is about 100 times wider than that of Jupiter. Our results show that planets can reside in much more massive stellar systems than what would be expected from extrapolation of previous results. The planet is unlikely to have formed in situ through the conventional core accretion mechanism4, but might have formed elsewhere and arrived to its present location through dynamical interactions, or might have formed via gravitational instability.
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| 39. |
- Kampinga, Harm H., et al.
(författare)
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Function, evolution, and structure of J-domain proteins
- 2019
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Ingår i: Cell stress & chaperones (Print). - : Springer Science and Business Media LLC. - 1355-8145 .- 1466-1268. ; 24:1, s. 7-15
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Forskningsöversikt (refereegranskat)abstract
- Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their facilitation of protein (re)folding, trafficking, remodeling, disaggregation, and degradation. Hsp70 machines are regulated by co-chaperones. J-domain containing proteins (JDPs) are the largest family of Hsp70 co-chaperones and play a determining role functionally specifying and directing Hsp70 functions. Many features of JDPs are not understood; however, a number of JDP experts gathered at a recent CSSI-sponsored workshop in Gdansk (Poland) to discuss various aspects of J-domain protein function, evolution, and structure. In this report, we present the main findings and the consensus reached to help direct future developments in the field of Hsp70 research.
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| 40. |
- Krat, S., et al.
(författare)
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Erosion at the inner wall of JET during the discharge campaign 2013-2014
- 2017
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Ingår i: Nuclear Materials and Energy. - : Elsevier. - 2352-1791. ; 11, s. 20-24
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Tidskriftsartikel (refereegranskat)abstract
- The erosion of Be and W marker layers was investigated using long-term samples containing marker layers during the second ITER-like wall discharge campaign 2013-2014 (ILW-2). The samples were mounted in Be coated Inconel tiles between the inner wall guard limiters (IWGL). They were analyzed using elastic backscattering (EBS) before and after exposure. All samples showed noticeable erosion. The results were compared to the data for Be and W erosion rates for the first 2011-2012 JET ITER-like wall (ILW-1) campaign, and to the data for C erosion during the 2005-2009 campaign when JET was operated with a carbon wall. The mean W erosion rates and the toroidal and poloidal distributions of the W erosion were nearly the same for the ILW-1 and ILW-2 campaigns. The mean erosion rate of Be during the ILW-2 campaign was smaller by a factor of about two compared to the ILW-1 campaign.
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| 41. |
- Lykou, F., et al.
(författare)
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Dissecting the AGB star L-2 Puppis : a torus in the making
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 576
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Tidskriftsartikel (refereegranskat)abstract
- Aims. The circumstellar environment of L-2 Pup, an oxygen-rich semiregular variable, was observed to understand the evolution of mass loss and the shaping of ejecta in the late stages of stellar evolution. Methods. High-angular resolution observations from a single 8 m telescope were obtained using aperture masking in the near-infrared (1.64, 2.30 and 3.74 mu m) on the NACO/VLT, both in imaging and polarimetric modes. Results. The aperture-masking images of L-2 Pup at 2.30 mu m show a resolved structure that resembles a toroidal structure with a major axis of similar to 140 milliarcseconds (mas) and an east-west orientation. Two clumps can be seen on either side of the star, similar to 65 mas from the star, beyond the edge of the circumstellar envelope (estimated diameter is similar to 27 mas), while a faint, hook-like structure appear toward the northeast. The patterns are visible both in the imaging and polarimetric mode, although the latter was only used to measure the total intensity (Stokes I). The overall shape of the structure is similar at the 3.74 mu m pseudo-continuum (dust emission), where the clumps appear to be embedded within a dark, dusty lane. The faint, hook-like patterns are also seen at this wavelength, extending northeast and southwest with the central, dark lane being an apparent axis of symmetry. We interpret the structure as a circumstellar torus with inner radius of 4.2 au. With a rotation velocity of 10 kms(-1) as suggested by the SiO maser profile, we estimate a stellar mass of 0.7 M-circle dot.
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| 42. |
- Maurer, Michael, et al.
(författare)
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Toxic Activation of an AAA plus Protease by the Antibacterial Drug Cyclomarin A
- 2019
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Ingår i: Cell Chemical Biology. - : Elsevier BV. - 2451-9456 .- 2451-9448. ; 26:8, s. 1169-1179
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Tidskriftsartikel (refereegranskat)abstract
- ATP-driven bacterial AAA+ proteases have been recognized as drug targets. They possess an AAA+ protein (e.g., ClpC), which threads substrate proteins into an associated peptidase (e.g., ClpP). ATPase activity and substrate selection of AAA+ proteins are regulated by adapter proteins that bind to regulatory domains, such as the N-terminal domain (NTD). The antibacterial peptide Cyclomarin A (CymA) kills Mycobacterium tuberculosis cells by binding to the NTD of ClpC. How CymA affects ClpC function is unknown. Here, we reveal the mechanism of CymA-induced toxicity. We engineered a CymA-sensitized ClpC chimera and show that CymA activates ATPase and proteolytic activities. CymA mimics adapter binding and enables autonomous protein degradation by ClpC/ClpP with relaxed substrate selectivity. We reconstitute CymA toxicity in E. coli cells expressing engineered ClpC and ClpP, demonstrating that gain of uncontrolled proteolytic activity causes cell death. This validates drug-induced overriding of AAA+ protease activity control as effective antibacterial strategy.
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| 43. |
- Mayer, M., et al.
(författare)
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Erosion and deposition in the JET divertor during the first ILW campaign
- 2016
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Ingår i: Physica Scripta. - : Institute of Physics Publishing (IOPP). - 0031-8949 .- 1402-4896. ; T167
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Tidskriftsartikel (refereegranskat)abstract
- Erosion and deposition were studied in the JET divertor during the first JET ITER-like wall campaign 2011 to 2012 using marker tiles. An almost complete poloidal section consisting of tiles 0, 1, 3, 4, 6, 7, 8 was studied. The data from divertor tile surfaces were completed by the analysis of samples from remote divertor areas and from the inner wall cladding. The total mass of material deposited in the divertor decreased by a factor of 4-9 compared to the deposition of carbon during all-carbon JET operation before 2010. Deposits in 2011 to 2012 consist mainly of beryllium with 5-20 at.% of carbon and oxygen, respectively, and small amounts of Ni, Cr, Fe and W. This decrease of material deposition in the divertor is accompanied by a decrease of total deuterium retention inside the JET vessel by a factor of 10 to 20. The detailed erosion/deposition pattern in the divertor with the ITER-like wall configuration shows rigorous changes compared to the pattern with the all-carbon JET configuration.
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