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- Berg, Anne Ingeborg, 1973, et al.
(författare)
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What matters, and what matters most, for change in life satisfaction in the oldest-old? A study over 6 years among individuals 80+.
- 2009
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Ingår i: Aging & mental health. - : Informa UK Limited. - 1364-6915 .- 1360-7863. ; 13:2, s. 191-201
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The study investigates whether markers of life satisfaction identified in a cross-sectional study-quality of social network, self-rated health, depressive symptoms, locus of control and widowhood, in addition to financial satisfaction and the personality traits of extraversion and neuroticism-predict change in life satisfaction (LSI-Z) across four measurement occasions during a 6-year period in individuals aged 80+. METHOD: Data were drawn from the Swedish OCTO-Twin-study of individuals aged 80 and older. RESULTS: Growth curve analysis showed a relatively consistent significant linear decline in life satisfaction, but certain markers predicted change in life satisfaction. The loss of spouse, in particular in men, and higher levels of depressive symptoms were related to lower levels of life satisfaction over time. CONCLUSION: The results from the study question the notion of a life-long stability of life satisfaction.
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- Blizard, David A., et al.
(författare)
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Blood pressure and heart rate QTL in mice of the B6/D2 lineage sex differences and environmental influences
- 2009
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Ingår i: Physiological Genomics. - : American Physiological Society. - 1094-8341 .- 1531-2267. ; 36:3, s. 158-166
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Tidskriftsartikel (refereegranskat)abstract
- A quantitative trait locus (QTL) approach was used to define the genetic architecture underlying variation in systolic blood pressure (SBP) and heart rate (HR), measured indirectly on seven occasions by the tail cuff procedure. The tests were conducted in 395 F(2) adult mice (197 males, 198 females) derived from a cross of the C57BL/6J (B6) and DBA/2J (D2) strains and in 22 BXD recombinant-inbred (RI) strains. Interval mapping of F(2) data for the first 5 days of measurement nominated one statistically significant and one suggestive QTL for SBP on chromosomes (Chr) 4 and 14, respectively, and two statistically significant QTL for HR on Chr 1 (which was specific to female mice) and Chr 5. New suggestive QTL emerged for SBP on Chr 3 (female-specific) and 8 and for HR on Chr 11 for measurements recorded several weeks after mice had undergone stressful blood sampling procedures. The two statistically significant HR QTL were confirmed by analyses of BXD RI strain means. Male and female F(2) mice did not differ in SBP or HR but RI strain analyses showed pronounced strain-by-sex interactions and a negative genetic correlation between the two measures in both sexes. Evidence for a role for mitochondrial DNA was found for both HR and SBP. QTL for HR and SBP may differ in males and females and may be sensitive to different environmental contexts.
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- Gold, Carol, et al.
(författare)
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Gender and patterns of cardiovascular diagnoses in an unlike-sex twin sample in Sweden
- 2007
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Ingår i: The Gerontological Society of America, 60th Annual Scientific Meeting, San Francisco. ; , s. 68-
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Konferensbidrag (refereegranskat)abstract
- Gender and Patterns of Cardiovascular Diagnoses and Year of Diagnoses in an Unlike-Sex Twin Sample in Sweden Cardiovascular disease is the number one cause of death for men and women. This study examined diagnoses in health records in a sample of older-unlike-sex twins in Sweden (N=249 pairs). A physician in Sweden has examined these twins’ medical records going back as far as 50 years and compiled a database with diagnoses based on ICD-10 codes and the year of diagnosis. A subsample of twinpairs was created in which both members had been diagnosed with at least one cardiovascular condition (N=140 pairs). The number of these conditions ranged from 1-8, with men having more than women (chi-square = 15.349, 7 d.f., p<.05). Analyses of the 4 most frequent conditions were conducted. We found 59 subjects with a diagnosis of myocardial infarction (45 men; 14 women), but only 4 concordant twinpairs; of those 2 brothers preceded their sister in year of diagnosis. We found 72 cases of congestive heart failure (43 men; 29 women), but only 12 concordant twinpairs; in half of those cases, the brother preceded his sister. We found 61 cases of stroke (34 men; 27 women), but only 12 concordant twinpairs; in 5 cases the brother preceded his sister. We found 181 subjects with arterial hypertension (77 men; 104 women), and 66 concordant twinpairs; in 31 of those twinpairs, the brother preceded his sister, and in 35 the sister preceded her brother. Additional pattern analyses will be presented that describe the arrays of cardiovascular co-morbidities and their year of diagnosis within twinpairs and the whole sample. Benefits and Learning Objectives To present pattern analyses of cardiovascular conditions in an unlike-sex twin sample
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- Lichtenstein, P, et al.
(författare)
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A co-twin--control study of response to widowhood
- 1996
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Ingår i: The journals of gerontology. Series B, Psychological sciences and social sciences. - : Oxford University Press (OUP). - 1079-5014 .- 1758-5368. ; 51:5, s. P279-P289
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Tidskriftsartikel (refereegranskat)
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- Lionikas, Arimantas, et al.
(författare)
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Genetic determinants of weight of fast- och slow-twitch skeletal muscles in old mice
- 2006
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Ingår i: Mammalian Genome Genes and Phenotypes. ; 17:6, s. 615-628
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Tidskriftsartikel (refereegranskat)abstract
- The main goal of the study was to explore the genetic architecture underlying muscle weight in old mice. Weight of soleus, tibialis anterior (TA), extensor digitorum longus (EDL), and gastrocnemius muscles was measured in the C57BL/6J (B6) and DBA/2J (D2) strains and derivative generations: a panel of the BXD recombinant inbred (RI) strains and a B6D2 F(2) intercross at the age of 800 days. The between-strain difference in muscle weight (B6 > D2) ranged between 16% and 38%. Linkage analysis identified suggestive quantitative trait loci (QTL) on Chromosomes (Chr) 2, 6, 7, 8, 19, and X that influenced muscle weight in the 800-day-old group. Comparison of weights at 200, 500, and 800 days revealed a variable effect of age among the four muscles. Linkage analysis in the B6D2 F(2) population combined across the three different age groups identified muscle-, sex-, and age-specific QTL on Chr 1, 2, 3, 5, 6, 8, 9, 11, 13, 17, X, and Y. Genetic factors that influence the rate of weight change (within-strain weight difference at two ages) over the lifespan of BXD RIs were mapped to the markers D2Mit369 and D3Mit130 at the genome-wide p < 0.05 for TA muscle in males (between 200 and 800 days) and females (between 500 and 800 days), respectively. Analysis of all age groups supported previous findings that the genetic effects may be muscle-, age-, and sex-specific.
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- Lionikas, Arimantas, et al.
(författare)
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Genomic Analysis of Variation in Hindlimb Musculature of Mice from the C57BL/6J and DBA/2J Lineage
- 2010
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Ingår i: Journal of Heredity. - : Oxford University Press (OUP). - 0022-1503 .- 1465-7333. ; 101:3, s. 360-367
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Tidskriftsartikel (refereegranskat)abstract
- The precise locations of attachment points of muscle to bone-the origin and insertion sites-are crucial anatomical and functional characteristics that influence locomotor performance. Mechanisms that control the development of these interactions between muscle, tendon, and bone are currently not well understood. In a subset of BXD recombinant inbred (RI) strains derived from the C57BL/6J and DBA/2J strains, we observed a soleus femoral attachment anomaly (SFAA) that was rare in both parental strains (Lionikas, Glover et al. 2006). The aim of the present study was to assess suitability of SFAA as a model to study the genetic mechanisms underlying variation in musculoskeletal anatomy. We scored the incidence of SFAA in 55 BXD strains (n = 9 to 136, median = 26, phenotyped animals per strain, for a total number of 2367). Seven strains (BXD1, 12, 38, 43, 48, 54, and 56) exhibited a high incidence of unilateral SFAA (47-89%), whereas 23 strains scored 0%. Exploration of the mechanisms underlying SFAA in 2 high incidence strains, BXD1 and BXD38, indicated that SFAA-relevant genes are to be found in both C57BL/6J and DBA/2J regions of the BXD1 genome. However, not all alleles relevant for the expression of the phenotype were shared between the 2 high-incidence BXD strains. In conclusion, the anatomical origin of the soleus muscle in mouse is controlled by a polygenic system. A panel of BXD RI strains is a useful tool in exploring the genetic mechanisms underlying SFAA and improving our understanding of musculoskeletal development.
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- Vasilopoulos, Terrie, et al.
(författare)
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Stability of genetic influences on pulmonary function in a longitudinal study of octogenarian twins.
- 2010
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Ingår i: American journal of human biology : the official journal of the Human Biology Council. - : Wiley. - 1520-6300 .- 1042-0533. ; 22:3, s. 375-7
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Tidskriftsartikel (refereegranskat)abstract
- Using data from the first four waves of the OCTO-Twin study (twins 80 + years), the present study investigated the stability and change of genetic and environmental contributions to pulmonary function. Using a genetic simplex model, variance in peak expiratory flow (PEF) at each wave was decomposed into additive genetic and nonshared (specific) environmental factors. Additionally, this analysis distinguished the source of these influences, either from previous waves (transmissions) or from novel influences at each wave (innovations). At each time point (except wave 1), the genetic variance was due to genetic transmissions from prior time points. Conversely, the specific environmental variance in PEF at each time point was mainly due to environmental innovations. These results imply that genetic factors contribute to the stability of pulmonary function over time whereas environmental factors contribute to its change.
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