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- Lorke, A., et al.
(författare)
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Technical note: drifting versus anchored flux chambers for measuring greenhouse gas emissions from running waters
- 2015
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Ingår i: Biogeosciences. - : COPERNICUS GESELLSCHAFT MBH. - 1726-4170 .- 1726-4189. ; 12:23, s. 7013-7024
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Tidskriftsartikel (refereegranskat)abstract
- Stream networks have recently been discovered to be major but poorly constrained natural greenhouse gas (GHG) sources. A fundamental problem is that several measurement approaches have been used without cross-comparisons. Flux chambers represent a potentially powerful methodological approach if robust and reliable ways to use chambers on running water can be defined. Here we compare the use of anchored and freely drifting chambers on various streams with different flow velocities. The study clearly shows that (1) anchored chambers enhance turbulence under the chambers and thus elevate fluxes, (2) drifting chambers have a very small impact on the water turbulence under the chamber and thus generate more reliable fluxes, (3) the bias of the anchored chambers greatly depends on chamber design and sampling conditions, and (4) there is a promising method to reduce the bias from anchored chambers by using a flexible plastic foil collar to seal the chambers to the water surface, rather than having rigid chamber walls penetrating into the water. Altogether, these results provide novel guidance on how to apply flux chambers in running water, which will have important consequences for measurements to constrain the global GHG balances.
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- Steinthorsdottir, V, et al.
(författare)
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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 5976-
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Tidskriftsartikel (refereegranskat)abstract
- Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
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- Baussan, E., et al.
(författare)
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A very intense neutrino super beam experiment for leptonic CP violation discovery based on the European spallation source linac
- 2014
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Ingår i: Nuclear Physics B. - : Elsevier BV. - 0550-3213 .- 1873-1562. ; 885, s. 127-149
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Tidskriftsartikel (refereegranskat)abstract
- Very intense neutrino beams and large neutrino detectors will be needed in order to enable the discovery of CP violation in the leptonic sector. We propose to use the proton linac of the European Spoliation Source currently under construction in Lund, Sweden, to deliver, in parallel with the spoliation neutron production, a very intense, cost effective and high performance neutrino beam. The baseline program for the European Spoliation Source linac is that it will be fully operational at 5 MW average power by 2022, producing 2 GeV 2.86 ms long proton pulses at a rate of 14 Hz. Our proposal is to upgrade the linac to 10 MW average power and 28 Hz, producing 14 pulses/s for neutron production and 14 pulses/s for neutrino production. Furthermore, because of the high current required in the pulsed neutrino horn, the length of the pulses used for neutrino production needs to be compressed to a few mu s with the aid of an accumulator ring. A long baseline experiment using this Super Beam and a megaton underground Water Cherenkov detector located in existing mines 300-600 km from Lund will make it possible to discover leptonic CP violation at 5 sigma significance level in up to 50% of the leptonic Dirac CP-violating phase range. This experiment could also determine the neutrino mass hierarchy at a significance level of more than 3 sigma if this issue will not already have been settled by other experiments by then. The mass hierarchy performance could be increased by combining the neutrino beam results with those obtained from atmospheric neutrinos detected by the same large volume detector. This detector will also be used to measure the proton lifetime, detect cosmological neutrinos and neutrinos from supernova explosions. Results on the sensitivity to leptonic CP violation and the neutrino mass hierarchy are presented.
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- Mesman, Jorrit P., 1993-, et al.
(författare)
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The role of internal feedbacks in shifting deep lake mixing regimes under a warming climate
- 2021
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Ingår i: Freshwater Biology. - : John Wiley & Sons. - 0046-5070 .- 1365-2427. ; 66:6, s. 1021-1035
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Forskningsöversikt (refereegranskat)abstract
- Climate warming is causing changes in the physics of deep lakes, such as longer summer stratification, increased water column stability, reduced ice cover, and a shallower depth of winter overturns. An ultimate consequence of warming would be a transition to a different mixing regime. Here we investigate the role of physical, chemical, and biological feedback mechanisms that unfold during a shift in mixing regime, and whether these feedbacks could prompt and stabilise the new regime. Although climate, interannual temperature variation, and lake morphometry are the main determinants of a mixing regime, when climate change causes shifts in mixing regime, internal feedback mechanisms may gain in importance and modify lake ecosystem functioning.We review the role of these feedbacks in three mixing regime shifts: from polymictic to seasonally stratified, from dimictic to monomictic, and from holomictic to oligomictic or meromictic.Polymictic lakes of intermediate depth (c. 3–10 m mean depth) could experience seasonal stratification if a stratification event triggers phytoplankton blooms or dissolved organic matter release, reducing transparency and therefore further heating the surface layer. However, this feedback is only likely to have influence in small and clear lakes, it would be easily disturbed by weather conditions, and the resulting stratified state does not remain stable in the long term, as stratification is lost in winter.The ice-albedo feedback might cause an accelerated shift from ice-covered (dimictic) to ice-free (monomictic) winters in sufficiently deep (mean depth 50 m or more) lakes, where temperature memory is carried over from one winter to the next. Nevertheless, there is an ongoing debate into whether this process can persist during natural weather variations and overcome self-stabilising mechanisms such as thermal insulation by snow. The majority of studies suggest that a gradual transition from dimictic to monomictic is more likely than an abrupt transition.A shift from a holomictic to a meromictic regime can occur if anoxia is triggered by incomplete mixing and an increase in deep-water density—through the accumulation of solutes—exceeds a density decrease by hypolimnetic warming. A shift to meromixis would strongly alter the biology of a lake and might be difficult to reverse. If solutes accumulate only minimally in the hypolimnion, an oligomictic regime is formed, in which years with complete and incomplete mixing alternate.Understanding the importance of feedback mechanisms and the role of biogeochemistry when lakes shift in mixing regime could lead to a better understanding of how climate change affects lake ecosystems.
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- Wadelius, Mia, et al.
(författare)
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The largest prospective warfarin-treated cohort supports genetic forecasting
- 2009
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 113:4, s. 784-792
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated. We genotyped 183 polymorphisms in 29 candidate genes in 1496 Swedish patients starting warfarin treatment, and tested for association with response. CYP2C9*2 and *3 explained 12% (P = 6.63 x 10(-34)) of the variation in warfarin dose, while a single VKORC1 SNP explained 30% (P = 9.82 x 10(-100)). No SNP outside the CYP2C gene cluster and VKORC1 regions was significantly associated with dose after correction for multiple testing. During initiation of therapy, homozygosity for CYP2C9 and VKORC1 variant alleles increased the risk of over-anticoagulation, hazard ratios 21.84 (95% CI 9.46; 50.42) and 4.56 (95% CI 2.85; 7.30), respectively. One of 8 patients with CYP2C9*3/*3 (12.5%) experienced severe bleeding during the first month compared with 0.27% of other patients (P = .066). A multiple regression model using the predictors CYP2C9, VKORC1, age, sex, and druginteractions explained 59% of the variance in warfarin dose, and 53% in an independent sample of 181 Swedish individuals. In conclusion, CYP2C9 and VKORC1 significantly influenced warfarin dose and predicted individuals predisposed to unstable anticoagulation. Our results strongly support that initiation of warfarin guided by pharmacogenetics would improve clinical outcome.
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| 11. |
- Wildner, E., et al.
(författare)
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The Opportunity Offered by the ESSnuSB Project to Exploit the Larger Leptonic CP Violation Signal at the Second Oscillation Maximum and the Requirements of This Project on the ESS Accelerator Complex
- 2016
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Ingår i: Advances in High Energy Physics. - : Hindawi Publishing Corporation. - 1687-7357 .- 1687-7365.
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Tidskriftsartikel (refereegranskat)abstract
- The European Spallation Source (ESS), currently under construction in Lund, Sweden, is a research center that will provide, by 2023, the world's most powerful neutron source. The average power of the proton linac will be 5 MW. Pulsing this linac at higher frequency will make it possible to raise the average total beam power to 10 MW to produce, in parallel with the spallation neutron production, a very intense neutrino Super Beam of about 0.4 GeV mean neutrino energy. This will allow searching for leptonic CP violation at the second oscillation maximum where the sensitivity is about 3 times higher than at the first. The ESS neutrino Super Beam, ESSnuSB operated with a 2.0 GeV linac proton beam, together with a large undergroundWater Cherenkov detector located at 540 km from Lund, will make it possible to discover leptonic CP violation at 5 sigma. significance level in 56% (65% for an upgrade to 2.5 GeV beam energy) of the leptonic CP-violating phase range after 10 years of data taking, assuming a 5% systematic error in the neutrino flux and 10% in the neutrino cross section. The paper presents the outstanding physics reach possible for CP violation with ESSnuSB obtainable under these assumptions for the systematic errors. It also describes the upgrade of the ESS accelerator complex required for ESSnuSB.
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