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Träfflista för sökning "WFRF:(Meehan Emma) "

Sökning: WFRF:(Meehan Emma)

  • Resultat 1-50 av 157
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  • Cockell, Charles S., et al. (författare)
  • Subsurface scientific exploration of extraterrestrial environments (MINAR 5) : analogue science, technology and education in the Boulby Mine, UK
  • 2019
  • Ingår i: International Journal of Astrobiology. - : Cambridges Institutes Press. - 1473-5504 .- 1475-3006. ; 18:2, s. 157-182
  • Tidskriftsartikel (refereegranskat)abstract
    • The deep subsurface of other planetary bodies is of special interest for robotic and human exploration. The subsurface provides access to planetary interior processes, thus yielding insights into planetary formation and evolution. On Mars, the subsurface might harbour the most habitable conditions. In the context of human exploration, the subsurface can provide refugia for habitation from extreme surface conditions. We describe the fifth Mine Analogue Research (MINAR 5) programme at 1 km depth in the Boulby Mine, UK in collaboration with Spaceward Bound NASA and the Kalam Centre, India, to test instruments and methods for the robotic and human exploration of deep environments on the Moon and Mars. The geological context in Permian evaporites provides an analogue to evaporitic materials on other planetary bodies such as Mars. A wide range of sample acquisition instruments (NASA drills, Small Planetary Impulse Tool (SPLIT) robotic hammer, universal sampling bags), analytical instruments (Raman spectroscopy, Close-Up Imager, Minion DNA sequencing technology, methane stable isotope analysis, biomolecule and metabolic life detection instruments) and environmental monitoring equipment (passive air particle sampler, particle detectors and environmental monitoring equipment) was deployed in an integrated campaign. Investigations included studying the geochemical signatures of chloride and sulphate evaporitic minerals, testing methods for life detection and planetary protection around human-tended operations, and investigations on the radiation environment of the deep subsurface. The MINAR analogue activity occurs in an active mine, showing how the development of space exploration technology can be used to contribute to addressing immediate Earth-based challenges. During the campaign, in collaboration with European Space Agency (ESA), MINAR was used for astronaut familiarization with future exploration tools and techniques. The campaign was used to develop primary and secondary school and primary to secondary transition curriculum materials on-site during the campaign which was focused on a classroom extra vehicular activity simulation.
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  • Reddington, James P, et al. (författare)
  • Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
  • 2013
  • Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 14:3, s. R25-
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: DNA methylation and the Polycomb repression system are epigenetic mechanisms that play important roles in maintaining transcriptional repression. Recent evidence suggests that DNA methylation can attenuate the binding of Polycomb protein components to chromatin and thus plays a role in determining their genomic targeting. However, whether this role of DNA methylation is important in the context of transcriptional regulation is unclear.RESULTS: By genome-wide mapping of the Polycomb Repressive Complex 2-signature histone mark, H3K27me3, in severely DNA hypomethylated mouse somatic cells, we show that hypomethylation leads to widespread H3K27me3 redistribution, in a manner that reflects the local DNA methylation status in wild-type cells. Unexpectedly, we observe striking loss of H3K27me3 and Polycomb Repressive Complex 2 from Polycomb target gene promoters in DNA hypomethylated cells, including Hox gene clusters. Importantly, we show that many of these genes become ectopically expressed in DNA hypomethylated cells, consistent with loss of Polycomb-mediated repression.CONCLUSIONS: An intact DNA methylome is required for appropriate Polycomb-mediated gene repression by constraining Polycomb Repressive Complex 2 targeting. These observations identify a previously unappreciated role for DNA methylation in gene regulation and therefore influence our understanding of how this epigenetic mechanism contributes to normal development and disease.
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  • Whitelaw, Nadia C, et al. (författare)
  • Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise
  • 2010
  • Ingår i: Genome Biology. - : BioMed Central. - 1465-6906 .- 1474-760X. ; 11:11
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process.RESULTS: Inbred mice heterozygous for a null mutation in DNA methyltransferase 3a (Dnmt3a) or tripartite motif protein 28 (Trim28) show greater coefficients of variance in body weight than their wild-type littermates. Trim28 mutants additionally develop metabolic syndrome and abnormal behavior with incomplete penetrance. Genome-wide gene expression analyses identified 284 significantly dysregulated genes in Trim28 heterozygote mutants compared to wild-type mice, with Mas1, which encodes a G-protein coupled receptor implicated in lipid metabolism, showing the greatest average change in expression (7.8-fold higher in mutants). This gene also showed highly variable expression between mutant individuals.CONCLUSIONS: These studies provide a molecular explanation of developmental noise in whole organisms and suggest that faithful epigenetic control of transcription is central to suppressing deleterious levels of phenotypic variation. These findings have broad implications for understanding the mechanisms underlying sporadic and complex disease in humans.
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  • Aad, G., et al. (författare)
  • 2014
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 90:4
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2013
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2013
  • Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 15
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Ingår i: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:8
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2015
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2013
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2015
  • Ingår i: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:7
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2013
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Ingår i: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:6
  • Tidskriftsartikel (refereegranskat)
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41.
  • Aad, G., et al. (författare)
  • 2015
  • Ingår i: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:7
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Ingår i: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:10
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2013
  • Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 15
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2013
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2012
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 90:2
  • Tidskriftsartikel (refereegranskat)
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  • Aad, G., et al. (författare)
  • 2014
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-50 av 157

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