| 1. |
- Abbasi, Rasha, et al.
(författare)
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IceCube search for neutrinos from GRB 221009A
- 2023
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Ingår i: Proceedings of 38th International Cosmic Ray Conference (ICRC 2023). - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- GRB 221009A is the brightest Gamma Ray Burst (GRB) ever observed. The observed extremelyhigh flux of high and very-high-energy photons provide a unique opportunity to probe the predictedneutrino counterpart to the electromagnetic emission. We have used a variety of methods to searchfor neutrinos in coincidence with the GRB over several time windows during the precursor, promptand afterglow phases of the GRB. MeV scale neutrinos are studied using photo-multiplier ratescalers which are normally used to search for galactic core-collapse supernovae neutrinos. GeVneutrinos are searched starting with DeepCore triggers. These events don’t have directionallocalization, but instead can indicate an excess in the rate of events. 10 GeV - 1 TeV and >TeVneutrinos are searched using traditional neutrino point source methods which take into accountthe direction and time of events with DeepCore and the entire IceCube detector respectively. The>TeV results include both a fast-response analysis conducted by IceCube in real-time with timewindows of T0 − 1 to T0 + 2 hours and T0 ± 1 day around the time of GRB 221009A, as well asan offline analysis with 3 new time windows up to a time window of T0 − 1 to T0 + 14 days, thelongest time period we consider. The combination of observations by IceCube covers 9 ordersof magnitude in neutrino energy, from MeV to PeV, placing upper limits across the range forpredicted neutrino emission.
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| 2. |
- Jenniskens, Peter, et al.
(författare)
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Fall, recovery, and characterization of the Novato L6 chondrite breccia
- 2014
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Ingår i: Meteoritics and Planetary Science. - : Wiley. - 1086-9379. ; 49:8, s. 1388-1425
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Tidskriftsartikel (refereegranskat)abstract
- The Novato L6 chondrite fragmental breccia fell in California on 17 October 2012, and was recovered after the Cameras for Allsky Meteor Surveillance (CAMS) project determined the meteor's trajectory between 95 and 46 km altitude. The final fragmentation from 42 to 22 km altitude was exceptionally well documented by digital photographs. The first sample was recovered before rain hit the area. First results from a consortium study of the meteorite's characterization, cosmogenic and radiogenic nuclides, origin, and conditions of the fall are presented. Some meteorites did not retain fusion crust and show evidence of spallation. Before entry, the meteoroid was 35 +/- 5 cm in diameter (mass 80 +/- 35 kg) with a cosmic-ray exposure age of 9 +/- 1 Ma, if it had a one-stage exposure history. A two-stage exposure history is more likely, with lower shielding in the last few Ma. Thermoluminescence data suggest a collision event within the last similar to 0.1 Ma. Novato probably belonged to the class of shocked L chondrites that have a common shock age of 470 Ma, based on the U, Th-He age of 420 +/- 220 Ma. The measured orbits of Novato, Jesenice, and Innisfree are consistent with a proposed origin of these shocked L chondrites in the Gefion asteroid family, perhaps directly via the 5: 2 mean-motion resonance with Jupiter. Novato experienced a stronger compaction than did other L6 chondrites of shock-stage S4. Despite this, a freshly broken surface shows a wide range of organic compounds.
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| 3. |
- Jenniskens, Peter, et al.
(författare)
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The Creston, California, meteorite fall and the origin of L chondrites
- 2019
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Ingår i: Meteoritics and Planetary Science. - : John Wiley & Sons. - 1086-9379 .- 1945-5100. ; 54:4, s. 699-720
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Tidskriftsartikel (refereegranskat)abstract
- It has been proposed that all L chondrites resulted from an ongoing collisional cascade of fragments that originated from the formation of the ~500 Ma old asteroid family Gefion, located near the 5:2 mean‐motion resonance with Jupiter in the middle Main Belt. If so, L chondrite pre‐atmospheric orbits should be distributed as expected for that source region. Here, we present contradictory results from the orbit and collisional history of the October 24, 2015, L6 ordinary chondrite fall at Creston, CA (here reclassified to L5/6). Creston's short 1.30 ± 0.02 AU semimajor axis orbit would imply a long dynamical evolution if it originated from the middle Main Belt. Indeed, Creston has a high cosmic ray exposure age of 40–50 Ma. However, Creston's small meteoroid size and low 4.23 ± 0.07° inclination indicate a short dynamical lifetime against collisions. This suggests, instead, that Creston originated most likely in the inner asteroid belt and was delivered via the ν6 resonance. The U‐Pb systematics of Creston apatite reveals a Pb‐Pb age of 4,497.1 ± 3.7 Ma, and an upper intercept U‐Pb age of 4,496.7 ± 5.8 Ma (2σ), circa 70 Ma after formation of CAI, as found for other L chondrites. The K‐Ar (age ~4.3 Ga) and U,Th‐He (age ~1 Ga) chronometers were not reset at ~500 Ma, while the lower intercept U‐Pb age is poorly defined as 770 ± 320 Ma. So far, the three known L chondrites that impacted on orbits with semimajor axes a <2.0 AU all have high (>3 Ga) K‐Ar ages. This argues for a source of some of our L chondrites in the inner Main Belt. Not all L chondrites originate in a continuous population of Gefion family debris stretching across the 3:1 mean‐motion resonance.
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| 4. |
- Jenniskens, Peter, et al.
(författare)
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The impact and recovery of asteroid 2018 LA
- 2021
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Ingår i: Meteoritics and Planetary Science. - : John Wiley & Sons. - 1086-9379 .- 1945-5100. ; 56:4, s. 844-893
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Tidskriftsartikel (refereegranskat)abstract
- The June 2, 2018 impact of asteroid 2018 LA over Botswana is only the second asteroid detected in space prior to impacting over land. Here, we report on the successful recovery of meteorites. Additional astrometric data refine the approach orbit and define the spin period and shape of the asteroid. Video observations of the fireball constrain the asteroid's position in its orbit and were used to triangulate the location of the fireball's main flare over the Central Kalahari Game Reserve. Twenty‐three meteorites were recovered. A consortium study of eight of these classifies Motopi Pan as an HED polymict breccia derived from howardite, cumulate and basaltic eucrite, and diogenite lithologies. Before impact, 2018 LA was a solid rock of ~156 cm diameter with high bulk density ~2.85 g cm−3, a relatively low albedo pV ~ 0.25, no significant opposition effect on the asteroid brightness, and an impact kinetic energy of ~0.2 kt. The orbit of 2018 LA is consistent with an origin at Vesta (or its Vestoids) and delivery into an Earth‐impacting orbit via the ν6 resonance. The impact that ejected 2018 LA in an orbit toward Earth occurred 22.8 ± 3.8 Ma ago. Zircons record a concordant U‐Pb age of 4563 ± 11 Ma and a consistent 207Pb/206Pb age of 4563 ± 6 Ma. A much younger Pb‐Pb phosphate resetting age of 4234 ± 41 Ma was found. From this impact chronology, we discuss what is the possible source crater of Motopi Pan and the age of Vesta's Veneneia impact basin.
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| 5. |
- Kita, Noriko T., et al.
(författare)
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Fall, classification, and exposure history of the Mifflin L5 chondrite
- 2013
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Ingår i: Meteoritics and Planetary Science. - : Wiley. - 1086-9379. ; 48:4, s. 641-655
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Tidskriftsartikel (refereegranskat)abstract
- The Mifflin meteorite fell on the night of April 14, 2010, in southwestern Wisconsin. A bright fireball was observed throughout a wide area of the midwestern United States. The petrography, mineral compositions, and oxygen isotope ratios indicate that the meteorite is a L5 chondrite fragmental breccia with light/dark structure. The meteorite shows a low shock stage of S2, although some shock-melted veins are present. The U,Th-He age is 0.7Ga, and the K-Ar age is 1.8Ga, indicating that Mifflin might have been heated at the time of the 470Ma L-chondrite parent body breakup and that U, Th-He, and K-Ar ages were partially reset. The cosmogenic radionuclide data indicate that Mifflin was exposed to cosmic rays while its radius was 3065cm. Assuming this exposure geometry, a cosmic-ray exposure age of 25 +/- 3Ma is calculated from cosmogenic noble gas concentrations. The low 22Ne/21Ne ratio may, however, indicate a two-stage exposure with a longer first-stage exposure at high shielding. Mifflin is unusual in having a low radiogenic gas content combined with a low shock stage and no evidence of late stage annealing; this inconsistency remains unexplained.
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| 6. |
- Schmitz, Birger, et al.
(författare)
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An extraterrestrial trigger for the mid-Ordovician ice age : Dust from the breakup of the L-chondrite parent body
- 2019
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 5:9
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Tidskriftsartikel (refereegranskat)abstract
- The breakup of the L-chondrite parent body in the asteroid belt 466 million years (Ma) ago still delivers almost a third of all meteorites falling on Earth. Our new extraterrestrial chromite and 3He data for Ordovician sediments show that the breakup took place just at the onset of a major, eustatic sea level fall previously attributed to an Ordovician ice age. Shortly after the breakup, the flux to Earth of the most fine-grained, extraterrestrial material increased by three to four orders of magnitude. In the present stratosphere, extraterrestrial dust represents 1% of all the dust and has no climatic significance. Extraordinary amounts of dust in the entire inner solar system during >2 Ma following the L-chondrite breakup cooled Earth and triggered Ordovician icehouse conditions, sea level fall, and major faunal turnovers related to the Great Ordovician Biodiversification Event.
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| 7. |
- Unsalan, Ozan, et al.
(författare)
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The Sariçiçek howardite fall in Turkey : Source crater of HED meteorites on Vesta and impact risk of Vestoids
- 2019
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Ingår i: Meteoritics and Planetary Science. - Hoboken : John Wiley & Sons. - 1086-9379 .- 1945-5100. ; 54:5, s. 953-1008
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Tidskriftsartikel (refereegranskat)abstract
- The Sariçiçek howardite meteorite shower consisting of 343 documented stones occurred on September 2, 2015 in Turkey and is the first documented howardite fall. Cosmogenic isotopes show that Sariçiçek experienced a complex cosmic‐ray exposure history, exposed during ~12–14 Ma in a regolith near the surface of a parent asteroid, and that an ~1 m sized meteoroid was launched by an impact 22 ± 2 Ma ago to Earth (as did one‐third of all HED meteorites). SIMS dating of zircon and baddeleyite yielded 4550.4 ± 2.5 Ma and 4553 ± 8.8 Ma crystallization ages for the basaltic magma clasts. The apatite U‐Pb age of 4525 ± 17 Ma, K‐Ar age of ~3.9 Ga, and the U,Th‐He ages of 1.8 ± 0.7 and 2.6 ± 0.3 Ga are interpreted to represent thermal metamorphic and impact‐related resetting ages, respectively. Petrographic; geochemical; and O‐, Cr‐, and Ti‐isotopic studies confirm that Sariçiçek belongs to the normal clan of HED meteorites. Petrographic observations and analysis of organic material indicate a small portion of carbonaceous chondrite material in the Sariçiçek regolith and organic contamination of the meteorite after a few days on soil. Video observations of the fall show an atmospheric entry at 17.3 ± 0.8 km s−1 from NW; fragmentations at 37, 33, 31, and 27 km altitude; and provide a pre‐atmospheric orbit that is the first dynamical link between the normal HED meteorite clan and the inner Main Belt. Spectral data indicate the similarity of Sariçiçek with the Vesta asteroid family (V‐class) spectra, a group of asteroids stretching to delivery resonances, which includes (4) Vesta. Dynamical modeling of meteoroid delivery to Earth shows that the complete disruption of a ~1 km sized Vesta family asteroid or a ~10 km sized impact crater on Vesta is required to provide sufficient meteoroids ≤4 m in size to account for the influx of meteorites from this HED clan. The 16.7 km diameter Antionia impact crater on Vesta was formed on terrain of the same age as given by the 4He retention age of Sariçiçek. Lunar scaling for crater production to crater counts of its ejecta blanket show it was formed ~22 Ma ago.
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| 8. |
- Aartsen, M. G., et al.
(författare)
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Improved limits on dark matter annihilation in the Sun with the 79-string IceCube detector and implications for supersymmetry
- 2016
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :4
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Tidskriftsartikel (refereegranskat)abstract
- We present an improved event-level likelihood formalism for including neutrino telescope data in global fits to new physics. We derive limits on spin-dependent dark matter-proton scattering by employing the new formalism in a re-analysis of data from the 79-string IceCube search for dark matter annihilation in the Sun, including explicit energy information for each event. The new analysis excludes a number of models in the weak-scale minimal supersymmetric standard model (MSSM) for the first time. This work is accompanied by the public release of the 79-string IceCube data, as well as an associated computer code for applying the new likelihood to arbitrary dark matter models.
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| 9. |
- Alwmark, Carl, et al.
(författare)
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A global rain of micrometeorites following breakup of the L-chondrite parent body-Evidence from solar wind-implanted Ne in fossil extraterrestrial chromite grains from China
- 2012
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Ingår i: Meteoritics and Planetary Science. - : Wiley. - 1086-9379. ; 47:8, s. 1297-1304
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies of limestone beds of mid-Ordovician age from both Sweden and China show that the Earth saw an at least two orders of magnitude increase in the influx of extraterrestrial material approximately 470 Ma, following the disruption of an L-chondrite parent body in the asteroid belt. Recovered extraterrestrial material consists of fossil meteorites and sediment-dispersed extraterrestrial chromite (SEC) grains, both with L-chondritic origin. Ne isotope analysis of SEC grains from one of the Swedish limestone sections revealed that the vast majority of the grains were delivered to Earth as micrometeorites. In this study, we extend the previous work, both in time and geographically, by measuring concentrations and isotopic ratios of Ne in individual SEC grains (60120 mu m in diameter) from three different beds from a contemporary Middle Ordovician limestone section in China. All of the Chinese SEC grains, 44 in total, contain surface-implanted Ne of fractionated solar wind composition, implying that these grains were, as in the case of the Swedish SEC grains, delivered to Earth as micrometeorites. This gives further compelling evidence that the two to three orders of magnitude increase in the influx of micrometeoritic material following the breakup of the L-chondrite parent body was indeed a global event. The rain of micrometeorites prevailed for at least 2 Myr (the estimated time of the deposition of the topmost Chinese bed) after the breakup event.
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| 10. |
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| 11. |
- Arndt, D. S., et al.
(författare)
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State of the Climate in 2016
- 2017
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 98:8, s. S1-S280
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Tidskriftsartikel (refereegranskat)abstract
- In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 +/- 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 +/- 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Nino events since at least 1950 dissipated in spring, and a weak La Nina evolved later in the year. Owing at least in part to the combination of El Nino conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44 degrees C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0 degrees C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8 degrees C, representing a 3.5 degrees C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 average. The September 2016 Arctic sea ice minimum extent tied with 2007 for the second lowest value on record, 33% lower than the 1981-2010 average. Arctic sea ice cover remains relatively young and thin, making it vulnerable to continued extensive melt. The mass of the Greenland Ice Sheet, which has the capacity to contribute similar to 7 m to sea level rise, reached a record low value. The onset of its surface melt was the second earliest, after 2012, in the 37-year satellite record. Sea surface temperature was record high at the global scale, surpassing the previous record of 2015 by about 0.01 degrees C. The global sea surface temperature trend for the 21st century-to-date of +0.162 degrees C decade(-1) is much higher than the longer term 1950-2016 trend of +0.100 degrees C decade(-1). Global annual mean sea level also reached a new record high, marking the sixth consecutive year of increase. Global annual ocean heat content saw a slight drop compared to the record high in 2015. Alpine glacier retreat continued around the globe, and preliminary data indicate that 2016 is the 37th consecutive year of negative annual mass balance. Across the Northern Hemisphere, snow cover for each month from February to June was among its four least extensive in the 47-year satellite record. Continuing a pattern below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska and at the Canadian observatory on northernmost Ellesmere Island. In the Antarctic, record low monthly surface pressures were broken at many stations, with the southern annular mode setting record high index values in March and June. Monthly high surface pressure records for August and November were set at several stations. During this period, record low daily and monthly sea ice extents were observed, with the November mean sea ice extent more than 5 standard deviations below the 1981-2010 average. These record low sea ice values contrast sharply with the record high values observed during 2012-14. Over the region, springtime Antarctic stratospheric ozone depletion was less severe relative to the 1991-2006 average, but ozone levels were still low compared to pre-1990 levels. Closer to the equator, 93 named tropical storms were observed during 2016, above the 1981-2010 average of 82, but fewer than the 101 storms recorded in 2015. Three basins-the North Atlantic, and eastern and western North Pacific-experienced above-normal activity in 2016. The Australian basin recorded its least active season since the beginning of the satellite era in 1970. Overall, four tropical cyclones reached the Saffir-Simpson category 5 intensity level. The strong El Nino at the beginning of the year that transitioned to a weak La Nina contributed to enhanced precipitation variability around the world. Wet conditions were observed throughout the year across southern South America, causing repeated heavy flooding in Argentina, Paraguay, and Uruguay. Wetter-than-usual conditions were also observed for eastern Europe and central Asia, alleviating the drought conditions of 2014 and 2015 in southern Russia. In the United States, California had its first wetter-than-average year since 2012, after being plagued by drought for several years. Even so, the area covered by drought in 2016 at the global scale was among the largest in the post-1950 record. For each month, at least 12% of land surfaces experienced severe drought conditions or worse, the longest such stretch in the record. In northeastern Brazil, drought conditions were observed for the fifth consecutive year, making this the longest drought on record in the region. Dry conditions were also observed in western Bolivia and Peru; it was Bolivia's worst drought in the past 25 years. In May, with abnormally warm and dry conditions already prevailing over western Canada for about a year, the human-induced Fort McMurray wildfire burned nearly 590000 hectares and became the costliest disaster in Canadian history, with $3 billion (U.S. dollars) in insured losses.
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| 12. |
- Arndt, D. S., et al.
(författare)
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STATE OF THE CLIMATE IN 2017
- 2018
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 99:8, s. S1-S310
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Forskningsöversikt (refereegranskat)
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| 13. |
- Blanckenhorn, Wolf U, et al.
(författare)
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Proximate causes of Rensch's rule : Does sexual size dimorphism in arthropods result from sex differences in development time?
- 2007
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Ingår i: American Naturalist. ; 169:2, s. 245-257
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Tidskriftsartikel (refereegranskat)abstract
- A prominent interspecific pattern of sexual size dimorphism (SSD) is Rensch's rule, according to which male body size is more variable or evolutionarily divergent than female body size. Assuming equal growth rates of males and females, SSD would be entirely mediated, and Rensch's rule proximately caused, by sexual differences in development times, or sexual bimaturism (SBM), with the larger sex developing for a proportionately longer time. Only a subset of the seven arthropod groups investigated in this study exhibits Rensch's rule. Furthermore, we found only a weak positive relationship between SSD and SBM overall, suggesting that growth rate differences between the sexes are more important than development time differences in proximately mediating SSD in a wide but by no means comprehensive range of arthropod taxa. Except when protandry is of selective advantage ( as in many butterflies, Hymenoptera, and spiders), male development time was equal to ( in water striders and beetles) or even longer than ( in drosophilid and sepsid flies) that of females. Because all taxa show female-biased SSD, this implies faster growth of females in general, a pattern markedly different from that of primates and birds (analyzed here for comparison). We discuss three potential explanations for this pattern based on life-history trade-offs and sexual selection.
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| 14. |
- Blunden, Jessica, et al.
(författare)
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State of the Climate in 2012
- 2013
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 94:8, s. S1-S258
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Tidskriftsartikel (refereegranskat)abstract
- For the first time in serveral years, the El Nino-Southern Oscillation did not dominate regional climate conditions around the globe. A weak La Ni a dissipated to ENSOneutral conditions by spring, and while El Nino appeared to be emerging during summer, this phase never fully developed as sea surface temperatures in the eastern conditions. Nevertheless, other large-scale climate patterns and extreme weather events impacted various regions during the year. A negative phase of the Arctic Oscillation from mid-January to early February contributed to frigid conditions in parts of northern Africa, eastern Europe, and western Asia. A lack of rain during the 2012 wet season led to the worst drought in at least the past three decades for northeastern Brazil. Central North America also experienced one of its most severe droughts on record. The Caribbean observed a very wet dry season and it was the Sahel's wettest rainy season in 50 years. Overall, the 2012 average temperature across global land and ocean surfaces ranked among the 10 warmest years on record. The global land surface temperature alone was also among the 10 warmest on record. In the upper atmosphere, the average stratospheric temperature was record or near-record cold, depending on the dataset. After a 30-year warming trend from 1970 to 1999 for global sea surface temperatures, the period 2000-12 had little further trend. This may be linked to the prevalence of La Ni a-like conditions during the 21st century. Heat content in the upper 700 m of the ocean remained near record high levels in 2012. Net increases from 2011 to 2012 were observed at 700-m to 2000-m depth and even in the abyssal ocean below. Following sharp decreases in to the effects of La Ni a, sea levels rebounded to reach records highs in 2012. The increased hydrological cycle seen in recent years continued, with more evaporation in drier locations and more precipitation in rainy areas. In a pattern that has held since 2004, salty areas of the ocean surfaces and subsurfaces were anomalously salty on average, while fresher areas were anomalously fresh. Global tropical cyclone activity during 2012 was near average, with a total of 84 storms compared with the 1981-2010 average of 89. Similar to 2010 and 2011, the North Atlantic was the only hurricane basin that experienced above-normal activity. In this basin, Sandy brought devastation to Cuba and parts of the eastern North American seaboard. All other basins experienced either near-or below-normal tropical cyclone activity. Only three tropical cyclones reached Category 5 intensity-all in Bopha became the only storm in the historical record to produce winds greater than 130 kt south of 7 N. It was also the costliest storm to affect the Philippines and killed more than 1000 residents. Minimum Arctic sea ice extent in September and Northern Hemisphere snow cover extent in June both reached new record lows. June snow cover extent is now declining at a faster rate (-17.6% per decade) than September sea ice extent (-13.0% per decade). Permafrost temperatures reached record high values in northernmost Alaska. A new melt extent record occurred on 11-12 July on the Greenland ice sheet; 97% of the ice sheet showed some form of melt, four times greater than the average melt for this time of year. The climate in Antarctica was relatively stable overall. The largest maximum sea ice extent since records begain in 1978 was observed in September 2012. In the stratosphere, warm air led to the second smallest ozone hole in the past two decades. Even so, the springtime ozone layer above Antarctica likely will not return to its early 1980s state until about 2060. Following a slight decline associated with the global 2 emissions from fossil fuel combustion and cement production reached a record 9.5 +/- 0.5 Pg C in 2011 and a new record of 9.7 +/- 0.5 Pg C is estimated for 2012. Atmospheric CO2 concentrations increased by 2.1 ppm in 2012, to 392.6 ppm. In spring 2012, 2 concentration exceeded 400 ppm at 7 of the 13 Arctic observation sites. Globally, other greenhouse gases including methane and nitrous oxide also continued to rise in concentration and the combined effect now represents a 32% increase in radiative forcing over a 1990 baseline. Concentrations of most ozone depleting substances continued to fall.
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| 15. |
- Bruederle, Daniel, et al.
(författare)
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A comprehensive workflow for general-purpose neural modeling with highly configurable neuromorphic hardware systems
- 2011
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Ingår i: Biological Cybernetics. - : Springer Science and Business Media LLC. - 0340-1200 .- 1432-0770. ; 104:4-5, s. 263-296
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems. We describe in detail a device with 45 million programmable and dynamic synapses that is currently under development, and we sketch the conceptual challenges that arise from taking this platform into operation. More specifically, we aim at the establishment of this neuromorphic system as a flexible and neuroscientifically valuable modeling tool that can be used by non-hardware experts. We consider various functional aspects to be crucial for this purpose, and we introduce a consistent workflow with detailed descriptions of all involved modules that implement the suggested steps: The integration of the hardware interface into the simulator-independent model description language PyNN; a fully automated translation between the PyNN domain and appropriate hardware configurations; an executable specification of the future neuromorphic system that can be seamlessly integrated into this biology-to-hardware mapping process as a test bench for all software layers and possible hardware design modifications; an evaluation scheme that deploys models from a dedicated benchmark library, compares the results generated by virtual or prototype hardware devices with reference software simulations and analyzes the differences. The integration of these components into one hardware-software workflow provides an ecosystem for ongoing preparative studies that support the hardware design process and represents the basis for the maturity of the model-to-hardware mapping software. The functionality and flexibility of the latter is proven with a variety of experimental results.
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| 16. |
- Daskalov, Asen, et al.
(författare)
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Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability.
- 2014
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Ingår i: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7366 .- 1553-7374. ; 10:6
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Tidskriftsartikel (refereegranskat)abstract
- The [Het-s] prion of the fungus Podospora anserina represents a good model system for studying the structure-function relationship in amyloid proteins because a high resolution solid-state NMR structure of the amyloid prion form of the HET-s prion forming domain (PFD) is available. The HET-s PFD adopts a specific β-solenoid fold with two rungs of β-strands delimiting a triangular hydrophobic core. A C-terminal loop folds back onto the rigid core region and forms a more dynamic semi-hydrophobic pocket extending the hydrophobic core. Herein, an alanine scanning mutagenesis of the HET-s PFD was conducted. Different structural elements identified in the prion fold such as the triangular hydrophobic core, the salt bridges, the asparagines ladders and the C-terminal loop were altered and the effect of these mutations on prion function, fibril structure and stability was assayed. Prion activity and structure were found to be very robust; only a few key mutations were able to corrupt structure and function. While some mutations strongly destabilize the fold, many substitutions in fact increase stability of the fold. This increase in structural stability did not influence prion formation propensity in vivo. However, if an Ala replacement did alter the structure of the core or did influence the shape of the denaturation curve, the corresponding variant showed a decreased prion efficacy. It is also the finding that in addition to the structural elements of the rigid core region, the aromatic residues in the C-terminal semi-hydrophobic pocket are critical for prion propagation. Mutations in the latter region either positively or negatively affected prion formation. We thus identify a region that modulates prion formation although it is not part of the rigid cross-β core, an observation that might be relevant to other amyloid models.
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| 17. |
- Feigin, Valery L, et al.
(författare)
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Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016.
- 2018
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Ingår i: The New England journal of medicine. - 1533-4406 .- 0028-4793. ; 379:25, s. 2429-2437
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Tidskriftsartikel (refereegranskat)abstract
- The lifetime risk of stroke has been calculated in a limited number of selected populations. We sought to estimate the lifetime risk of stroke at the regional, country, and global level using data from a comprehensive study of the prevalence of major diseases.We used the Global Burden of Disease (GBD) Study 2016 estimates of stroke incidence and the competing risks of death from any cause other than stroke to calculate the cumulative lifetime risks of first stroke, ischemic stroke, or hemorrhagic stroke among adults 25 years of age or older. Estimates of the lifetime risks in the years 1990 and 2016 were compared. Countries were categorized into quintiles of the sociodemographic index (SDI) used in the GBD Study, and the risks were compared across quintiles. Comparisons were made with the use of point estimates and uncertainty intervals representing the 2.5th and 97.5th percentiles around the estimate.The estimated global lifetime risk of stroke from the age of 25 years onward was 24.9% (95% uncertainty interval, 23.5 to 26.2); the risk among men was 24.7% (95% uncertainty interval, 23.3 to 26.0), and the risk among women was 25.1% (95% uncertainty interval, 23.7 to 26.5). The risk of ischemic stroke was 18.3%, and the risk of hemorrhagic stroke was 8.2%. In high-SDI, high-middle-SDI, and low-SDI countries, the estimated lifetime risk of stroke was 23.5%, 31.1% (highest risk), and 13.2% (lowest risk), respectively; the 95% uncertainty intervals did not overlap between these categories. The highest estimated lifetime risks of stroke according to GBD region were in East Asia (38.8%), Central Europe (31.7%), and Eastern Europe (31.6%), and the lowest risk was in eastern sub-Saharan Africa (11.8%). The mean global lifetime risk of stroke increased from 22.8% in 1990 to 24.9% in 2016, a relative increase of 8.9% (95% uncertainty interval, 6.2 to 11.5); the competing risk of death from any cause other than stroke was considered in this calculation.In 2016, the global lifetime risk of stroke from the age of 25 years onward was approximately 25% among both men and women. There was geographic variation in the lifetime risk of stroke, with the highest risks in East Asia, Central Europe, and Eastern Europe. (Funded by the Bill and Melinda Gates Foundation.).
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| 18. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of neurological disorders, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016
- 2019
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 18:5, s. 459-480
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Tidskriftsartikel (refereegranskat)abstract
- Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.Funding: Bill & Melinda Gates Foundation.
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| 19. |
- Franz, D, et al.
(författare)
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Towards long-term standardised carbon and greenhouse gas observations for monitoring Europe´s terrestrial ecosystems: a review
- 2018
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Ingår i: International Agrophysics. - : Walter de Gruyter GmbH. - 0236-8722 .- 2300-8725. ; 32, s. 439-455
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Tidskriftsartikel (refereegranskat)abstract
- Research infrastructures play a key role in launching a new generation of integrated long-term, geographically distributed observation programmes designed to monitor climate change, better understand its impacts on global ecosystems, and evaluate possible mitigation and adaptation strategies. The pan-European Integrated Carbon Observation System combines carbon and greenhouse gas (GHG; CO2, CH4, N2O, H2O) observations within the atmosphere, terrestrial ecosystems and oceans. High-precision measurements are obtained using standardised methodologies, are centrally processed and openly available in a traceable and verifiable fashion in combination with detailed metadata. The Integrated Carbon Observation System ecosystem station network aims to sample climate and land-cover variability across Europe. In addition to GHG flux measurements, a large set of complementary data (including management practices, vegetation and soil characteristics) is collected to support the interpretation, spatial upscaling and modelling of observed ecosystem carbon and GHG dynamics. The applied sampling design was developed and formulated in protocols by the scientific community, representing a trade-off between an ideal dataset and practical feasibility. The use of open-access, high-quality and multi-level data products by different user communities is crucial for the Integrated Carbon Observation System in order to achieve its scientific potential and societal value.
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| 20. |
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| 21. |
- Goette, L., et al.
(författare)
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Competition between organizational groups: Its impact on altruistic and antisocial motivations
- 2012
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Ingår i: Management Science. - : Institute for Operations Research and the Management Sciences (INFORMS). - 0025-1909 .- 1526-5501. ; 58:5, s. 948-960
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Tidskriftsartikel (refereegranskat)abstract
- Firms are often organized into groups. Group membership has been shown empirically to have positive effects, in the form of increased prosocial behavior toward in-group members. This includes an enhanced willingness to engage in altruistic punishment of inefficient defection. Our paper provides evidence of a dark side of group membership. In the presence of cues of competition between groups, a taste for harming the out-group emerges: punishment ceases to serve a norm enforcement function, and instead, out-group members are punished harder and regardless of whether they cooperate or defect. Our results point to a mechanism that might help explain previous mixed results on the social value of punishment, and they contribute to understanding the sources of conflict between groups. They also point to an important trade-off for firms: introducing competition enhances within-group efficiency but also generates costly between-group conflict.
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| 22. |
- Gröger, Matthias, et al.
(författare)
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Coupled regional Earth system modeling in the Baltic Sea region
- 2021
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Ingår i: Earth System Dynamics. - : Copernicus GmbH. - 2190-4979 .- 2190-4987. ; 12:3, s. 939-973
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Forskningsöversikt (refereegranskat)abstract
- Nonlinear responses to externally forced climate change are known to dampen or amplify the local climate impact due to complex cross-compartmental feedback loops in the Earth system. These feedbacks are less well represented in the traditional stand-alone atmosphere and ocean models on which many of today's regional climate assessments rely (e.g., EURO-CORDEX, NOSCCA and BACC II). This has promoted the development of regional climate models for the Baltic Sea region by coupling different compartments of the Earth system into more comprehensive models. Coupled models more realistically represent feedback loops than the information imposed on the region by prescribed boundary conditions and, thus, permit more degrees of freedom. In the past, several coupled model systems have been developed for Europe and the Baltic Sea region. This article reviews recent progress on model systems that allow two-way communication between atmosphere and ocean models; models for the land surface, including the terrestrial biosphere; and wave models at the air-sea interface and hydrology models for water cycle closure. However, several processes that have mostly been realized by one-way coupling to date, such as marine biogeochemistry, nutrient cycling and atmospheric chemistry (e.g., aerosols), are not considered here. In contrast to uncoupled stand-alone models, coupled Earth system models can modify mean near-surface air temperatures locally by up to several degrees compared with their stand-alone atmospheric counterparts using prescribed surface boundary conditions. The representation of small-scale oceanic processes, such as vertical mixing and sea-ice dynamics, appears essential to accurately resolve the air-sea heat exchange over the Baltic Sea, and these parameters can only be provided by online coupled high-resolution ocean models. In addition, the coupling of wave models at the ocean-atmosphere interface allows for a more explicit formulation of small-scale to microphysical processes with local feedbacks to water temperature and large-scale processes such as oceanic upwelling. Over land, important climate feedbacks arise from dynamical terrestrial vegetation changes as well as the implementation of land-use scenarios and afforestation/deforestation that further alter surface albedo, roughness length and evapotranspiration. Furthermore, a good representation of surface temperatures and roughness length over open sea and land areas is critical for the representation of climatic extremes such as heavy precipitation, storms, or tropical nights (defined as nights where the daily minimum temperature does not fall below 20gC), and these parameters appear to be sensitive to coupling. For the present-day climate, many coupled atmosphere-ocean and atmosphere-land surface models have demonstrated the added value of single climate variables, in particular when low-quality boundary data were used in the respective stand-alone model. This makes coupled models a prospective tool for downscaling climate change scenarios from global climate models because these models often have large biases on the regional scale. However, the coupling of hydrology models to close the water cycle remains problematic, as the accuracy of precipitation provided by atmosphere models is, in most cases, insufficient to realistically simulate the runoff to the Baltic Sea without bias adjustments. Many regional stand-alone ocean and atmosphere models are tuned to suitably represent present-day climatologies rather than to accurately simulate climate change. Therefore, more research is required into how the regional climate sensitivity (e.g., the models' response to a given change in global mean temperature) is affected by coupling and how the spread is altered in multi-model and multi-scenario ensembles of coupled models compared with uncoupled ones.
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| 23. |
- Holm-Alwmark, Sanna, et al.
(författare)
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Shocked quartz in distal ejecta from the Ries impact event (Germany) found at ~ 180 km distance, near Bernhardzell, eastern Switzerland
- 2021
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Impact ejecta formation and emplacement is of great importance when it comes to understanding the process of impact cratering and consequences of impact events in general. Here we present a multidisciplinary investigation of a distal impact ejecta layer, the Blockhorizont, that occurs near Bernhardzell in eastern Switzerland. We provide unambiguous evidence that this layer is impact-related by confirming the presence of shocked quartz grains exhibiting multiple sets of planar deformation features. Average shock pressures recorded by the quartz grains are ~ 19 GPa for the investigated sample. U–Pb dating of zircon grains from bentonites in close stratigraphic context allows us to constrain the depositional age of the Blockhorizont to ~ 14.8 Ma. This age, in combination with geochemical and paleontological analysis of ejecta particles, is consistent with deposition of this material as distal impact ejecta from the Ries impact structure, located ~ 180 km away, in Germany. Our observations are important for constraining models of impact ejecta emplacement as ballistically and non-ballistically transported fragments, derived from vastly different depths in the pre-impact target, occur together within the ejecta layer. These observations make the Ries ejecta one of the most completely preserved ejecta deposit on Earth for an impact structure of that size.
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| 24. |
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| 25. |
- Kotilainen, Aarno T., et al.
(författare)
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Echoes from the Past : A Healthy Baltic Sea Requires More Effort
- 2014
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Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 43:1, s. 60-68
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Tidskriftsartikel (refereegranskat)abstract
- Integrated sediment multiproxy studies and modeling were used to reconstruct past changes in the Baltic Sea ecosystem. Results of natural changes over the past 6000 years in the Baltic Sea ecosystem suggest that forecasted climate warming might enhance environmental problems of the Baltic Sea. Integrated modeling and sediment proxy studies reveal increased sea surface temperatures and expanded seafloor anoxia (in deep basins) during earlier natural warm climate phases, such as the Medieval Climate Anomaly. Under future IPCC scenarios of global warming, there is likely no improvement of bottom water conditions in the Baltic Sea. Thus, the measures already designed to produce a healthier Baltic Sea are insufficient in the long term. The interactions between climate change and anthropogenic impacts on the Baltic Sea should be considered in management, implementation of policy strategies in the Baltic Sea environmental issues, and adaptation to future climate change.
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| 26. |
- Leo, N., et al.
(författare)
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Magnetoelectric inversion of domain patterns
- 2018
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 560:7719, s. 466-
-
Tidskriftsartikel (refereegranskat)abstract
- The inversion of inhomogeneous physical states has great technological importance; for example, active noise reduction relies on the emission of an inverted sound wave that interferes destructively with the noise of the emitter(1), and inverting the evolution of a spin system by using a magnetic-field pulse enables magnetic resonance tomography(2). In contrast to these examples, inversion of a distribution of ferromagnetic or ferroelectric domains within a material is surprisingly difficult: field poling creates a single-domain state, and piece-by-piece inversion using a scanning tip is impractical. Here we report inversion of entire ferromagnetic and ferroelectric domain patterns in the magnetoelectric material Co3TeO6 and the multiferroic material Mn2GeO4, respectively. In these materials, an applied magnetic field reverses the magnetization or polarization, respectively, of each domain, but leaves the domain pattern intact. Landau theory indicates that this type of magnetoelectric inversion is universal across materials that exhibit complex ordering, with one order parameter holding the memory of the domain structure and another setting its overall sign. Domain-pattern inversion is only one example of a previously unnoticed effect in systems such as multiferroics, in which several order parameters are available for combination. Exploring these effects could therefore advance multiferroics towards new levels of functionality.
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| 27. |
- Meier, H. E. Markus, et al.
(författare)
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Assessment of Eutrophication Abatement Scenarios for the Baltic Sea by Multi-Model Ensemble Simulations
- 2018
-
Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- To assess the impact of the implementation of the Baltic Sea Action Plan (BSAP) on the future environmental status of the Baltic Sea, available uncoordinated multi-model ensemble simulations for the Baltic Sea region for the twenty-first century were analyzed. The scenario simulations were driven by regionalized global general circulation model (GCM) data using several regional climate system models and forced by various future greenhouse gas emission and air- and river-borne nutrient load scenarios following either reference conditions or the BSAP. To estimate uncertainties in projections, the largest ever multi-model ensemble for the Baltic Sea comprising 58 transient simulations for the twenty-first century was assessed. Data from already existing simulations from different projects including regionalized GCM simulations of the third and fourth assessment reports of the Intergovernmental Panel on Climate Change based on the corresponding Coupled Model Intercomparison Projects, CMIP3 and CMIP5, were collected.Various strategies to weigh the ensemble members were tested and the results for ensemble mean changes between future and present climates are shown to be robust with respect to the chosen metric. Although (1) the model simulations during the historical period are of different quality and (2) the assumptions on nutrient load levels during present and future periods differ between models considerably, the ensemble mean changes in biogeochemical variables in the Baltic proper with respect to nutrient load reductions are similar between the entire ensemble and a subset consisting only of the most reliable simulations.Despite the large spread in projections, the implementation of the BSAP will lead to a significant improvement of the environmental status of the Baltic Sea according to both weighted and unweighted ensembles. The results emphasize the need for investigating ensembles with many members and rigorous assessments of models’ performance.
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| 28. |
- Meier, H. E. Markus, et al.
(författare)
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Assessment of Uncertainties in Scenario Simulations of Biogeochemical Cycles in the Baltic Sea
- 2019
-
Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745. ; 6
-
Forskningsöversikt (refereegranskat)abstract
- Following earlier regional assessment studies, such as the Assessment of Climate Change for the Baltic Sea Basin and the North Sea Region Climate Change Assessment, knowledge acquired from available literature about future scenario simulations of biogeochemical cycles in the Baltic Sea and their uncertainties is assessed. The identification and reduction of uncertainties of scenario simulations are issues for marine management. For instance, it is important to know whether nutrient load abatement will meet its objectives of restored water quality status in future climate or whether additional measures are required. However, uncertainties are large and their sources need to be understood to draw conclusions about the effectiveness of measures. The assessment of sources of uncertainties in projections of biogeochemical cycles based on authors' own expert judgment suggests that the biggest uncertainties are caused by (1) unknown current and future bioavailable nutrient loads from land and atmosphere, (2) the experimental setup (including the spin up strategy), (3) differences between the projections of global and regional climate models, in particular, with respect to the global mean sea level rise and regional water cycle, (4) differing model-specific responses of the simulated biogeochemical cycles to long-term changes in external nutrient loads and climate of the Baltic Sea region, and (5) unknown future greenhouse gas emissions. Regular assessments of the models' skill (or quality compared to observations) for the Baltic Sea region and the spread in scenario simulations (differences among projected changes) as well as improvement of dynamical downscaling methods are recommended.
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| 29. |
- Meier, Matthias, et al.
(författare)
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A noble gas and cosmogenic radionuclide analysis of two ordinary chondrites from Almahata Sitta
- 2012
-
Ingår i: Meteoritics and Planetary Science. - : Wiley. - 1086-9379. ; 47:6, s. 1075-1086
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of a noble gas (He, Ne, Ar) and cosmogenic radionuclide (10Be, 26Al, 36Cl) analysis of two chondritic fragments (#A100, L4 and #25, H5) found in the Almahata Sitta strewn field in Sudan. We confirm their earlier attribution to the same fall as the ureilites dominating the strewn field, based on the following findings: (1) both chondrite samples indicate a preatmospheric radius of approximately 300 g cm-2, consistent with the preatmospheric size of asteroid 2008 TC3 that produced the Almahata Sitta strewn field; (2) both have, within error, a 21Ne/26Al-based cosmic ray exposure age of approximately 20 Ma, identical to the reported ages of Almahata Sitta ureilites; (3) both exhibit hints of ureilitic Ar in the trapped component. We discuss a possible earlier irradiation phase for the two fragments of approximately 1020 Ma, visible only in cosmogenic 38Ar. We also discuss the approximately 3.8 Ga (4He) and approximately 4.6 Ga (40Ar) gas retention ages, measured in both chondritic fragments. These imply that the two chondrite fragments were incorporated into the ureilite host early in solar system evolution, and that the parent asteroid from which 2008 TC3 is derived has not experienced a large break-up event in the last 3.8 Ga.
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| 30. |
- Meier, Matthias, et al.
(författare)
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Cosmic-ray exposure ages of fossil micrometeorites from mid-Ordovician sediments at Lynna River, Russia
- 2014
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Ingår i: Geochimica et Cosmochimica Acta. - : Elsevier BV. - 0016-7037. ; 125, s. 338-350
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Tidskriftsartikel (refereegranskat)abstract
- We measured the He and Ne concentrations of 50 individual extraterrestrial chromite grains recovered from mid-Ordovician (lower Darriwilian) sediments from the Lynna River section near St. Petersburg, Russia. High concentrations of solar wind-like He and Ne found in most grains indicate that they were delivered to Earth as micrometeoritic dust, while their abundance, stratigraphic position and major element composition indicate an origin related to the L chondrite parent body (LCPB) break-up event, 470 Ma ago. Compared to sediment-dispersed extraterrestrial chromite (SEC) grains extracted from coeval sediments at other localities, the grains from Lynna River are both highly concentrated and well preserved. As in previous work, in most grains from Lynna River, high concentrations of solar wind-derived He and Ne impede a clear quantification of cosmic-ray produced He and Ne. However, we have found several SEC grains poor in solar wind Ne, showing a resolvable contribution of cosmogenic Ne-21. This makes it possible, for the first time, to determine robust cosmic-ray exposure (CRE) ages in these fossil micrometeorites, on the order of a few hundred-thousand years. These ages are similar to the CRE ages measured in chromite grains from cm-sized fossil meteorites recovered from coeval sediments in Sweden. As the CRE ages are shorter than the orbital decay time of grains of this size by Poynting-Robertson drag, this suggests that the grains were delivered to Earth through direct injection into an orbital resonance. We demonstrate how CRE ages of fossil micrometeorites can be used, in principle, to determine sedimentation rates, and to correlate the sediments at Lynna River with the fossil meteorite-bearing sediment layers in Sweden. In some grains with high concentrations of solar wind Ne, we nevertheless find a well-resolved cosmogenic Ne-21 signal. These grains must have been exposed for up to several 10 Ma in the regolith layer of the pre-break-up L chondrite parent body. This confirms an earlier suggestion that such regolith grains should be abundant in sediments deposited shortly after the break-up of the LCPB asteroid. (C) 2013 Elsevier Ltd. All rights reserved.
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| 31. |
- Meier, Matthias, et al.
(författare)
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Graphite grains in supernova ejecta - Insights from a noble gas study of 91 individual KFC1 presolar graphite grains from the Murchison meteorite
- 2012
-
Ingår i: Geochimica et Cosmochimica Acta. - : Elsevier BV. - 0016-7037. ; 76, s. 147-160
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Tidskriftsartikel (refereegranskat)abstract
- We have measured helium and neon concentrations, elemental and isotopic ratios of 91 individual presolar graphite grains from the KFC1 density separate of the Murchison meteorite. Eleven grains contain measurable amounts of either (4)He, (20)Ne, (21)Ne or (22)Ne, or a combination thereof. We report the first detection of (21)Ne from an individual presolar graphite grain and the first detection of (4)He and (20)Ne in individual KFC1 graphite grains. Six of the gas-rich grains originate from asymptotic giant branch (AGB) stars, while another five are likely derived from core-collapse supernovae. The mono-isotopic (22)Ne detected in one supernova grain is either radiogenic and compatible with condensation in the O/Ne zone, or nucleosynthetic and derived from the He/C zone. Two grains with (20)Ne and (12)C/(13)C < 10 are consistent with condensation and Ne acquisition in a similar to 80:20 mixture of material from the H envelope and He/N zone. The isotopic ratios of a single grain with (21)Ne and (22)Ne, and a further grain with (20)Ne and (22)Ne are compatible with condensation and Ne acquisition in the C/O zone. We discuss the implications of our study on the understanding of processes in supernova ejecta. (C) 2011 Elsevier Ltd. All rights reserved.
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| 32. |
- Meier, Matthias, et al.
(författare)
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He and Ne in individual chromite grains from the regolith breccia Ghubara (L5): Exploring the history of the L chondrite parent body regolith
- 2014
-
Ingår i: Meteoritics and Planetary Science. - : Wiley. - 1086-9379 .- 1945-5100. ; 49:4, s. 576-594
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Tidskriftsartikel (refereegranskat)abstract
- Abstract We analyzed He and Ne in chromite grains from the regolith breccia Ghubara (L5), to compare it with He and Ne in sediment-dispersed extraterrestrial chromite (SEC) grains from mid-Ordovician sediments. These SEC grains arrived on Earth as micrometeorites in the aftermath of the L chondrite parent body (LCPB) breakup event, 470 Ma ago. A significant fraction of them show prolonged exposure to galactic cosmic rays for up to several 10 Ma. The majority of the cosmogenic noble gases in these grains were probably acquired in the regolith of the LCPB (Meier et al. ). Ghubara, an L chondritic regolith breccia with an Ar-Ar shock age of 470 Ma, is a sample of that regolith. We find cosmic-ray exposure ages of up to several 10 Ma in some Ghubara chromite grains, confirming for the first time that individual chromite grains with such high exposure ages indeed existed in the LCPB regolith, and that the > 10 Ma cosmic-ray exposure ages found in recent micrometeorites are thus not necessarily indicative of an origin in the Kuiper Belt. Some Ghubara chromite grains show much lower concentrations of cosmogenic He and Ne, indicating that the 4 pi (last-stage) exposure age of the Ghubara meteoroid lasted only 4-6 Ma. This exposure age is considerably shorter than the 15-20 Ma suggested before from bulk analyses, indicating that bulk samples have seen regolith pre-exposure as well. The shorter last-stage exposure age probably links Ghubara to a small peak of Ar-40-poor L5 chondrites of the same exposure age. Furthermore, and quite unexpectedly, we find a Ne component similar to presolar Ne-HL in the chromite grains, perhaps indicating that some presolar Ne can be preserved even in meteorites of petrologic type 5.
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| 33. |
- Meier, Matthias M.M., et al.
(författare)
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A tale of clusters : No resolvable periodicity in the terrestrial impact cratering record
- 2017
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 467:3, s. 2545-2551
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Tidskriftsartikel (refereegranskat)abstract
- Rampino & Caldeira carry out a circular spectral analysis (CSA) of the terrestrial impact cratering record over the past 260 million years (Ma), and suggest a ∼26 Ma periodicity of impact events. For some of the impacts in that analysis, new accurate and high-precision ('robust'; 2SE < 2 per cent) 40Ar-39Ar ages have recently been published, resulting in significant age shifts. In a CSA of the updated impact age list, the periodicity is strongly reduced. In a CSA of a list containing only impacts with robust ages, we find no significant periodicity for the last 500 Ma. We show that if we relax the assumption of a fully periodic impact record, assuming it to be a mix of a periodic and a random component instead, we should have found a periodic component if it contributes more than ∼80 per cent of the impacts in the last 260 Ma. The difference between our CSA and the one by Rampino & Caldeira originates in a subset of 'clustered' impacts (i.e. with overlapping ages). The ∼26 Ma periodicity seemingly carried by these clusters alone is strongly significant if tested against a random distribution of ages, but this significance disappears if it is tested against a distribution containing (randomly spaced) clusters. The presence of a few impact age clusters (e.g. from asteroid break-up events) in an otherwise random impact record can thus give rise to false periodicity peaks in a CSA. There is currently no evidence for periodicity in the impact record.
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| 34. |
- Meier, Matthias
(författare)
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MOON FORMATION Earth's titanium twin
- 2012
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Ingår i: Nature Geoscience. - : Springer Science and Business Media LLC. - 1752-0908 .- 1752-0894. ; 5:4, s. 240-241
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 35. |
- Meier, Matthias, et al.
(författare)
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No evidence for a decrease of nuclear decay rates with increasing heliocentric distance based on radiochronology of meteorites
- 2014
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Ingår i: Astroparticle Physics. - : Elsevier BV. - 1873-2852 .- 0927-6505. ; 55, s. 63-75
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Tidskriftsartikel (refereegranskat)abstract
- It has been argued that the decay rates of several radioactive nuclides are slightly lower at Earth's aphelion than at perihelion, and that this effect might depend on heliocentric distance. It might then be expected that nuclear decay rates be considerably lower at larger distances from the sun, e.g., in the asteroid belt at 2-3 AU from where most meteorites originate. If so, ages of meteorites obtained by analyses of radioactive nuclides and their stable daughter isotopes might be in error, since these ages are based on decay rates determined on Earth. Here we evaluate whether the large data base on nuclear cosmochronology offers any hint for discrepancies which might be due to radially variable decay rates. Chlorine-36 (t(1/2) = 301,000 a) is produced in meteorites by interactions with cosmic rays and is the nuclide for which a decay rate dependence from heliocentric distance has been proposed, which, in principle, can be tested with our approach and the current data base. We show that compilations of Cl-36 concentrations measured in meteorites offer no support for a spatially variable Cl-36 decay rate. For very short-lived cosmic-ray produced radionuclides (half-lives < 10-100 days), the concentration should be different for meteorites hitting the Earth on the incoming vs. outgoing part of their orbit. However, the current data base of very short-lived radionuclides in freshly fallen meteorites is far from sufficient to deduce solid constraints. Constraints on the age of the Earth and the oldest meteorite phases obtained by the U-Pb dating technique give no hints for radially variable decay rates of the alpha-decaying nuclides U-235 or U-238. Similarly, some of the oldest phases in meteorites have U-Pb ages whose differences agree almost perfectly with respective age differences obtained with "short-lived" radionuclides present in the early solar system, again indicating no variability of uranium decay rates in different meteorite parent bodies in the asteroid belt. Moreover, the oldest U-Pb ages of meteorites agree with the main-sequence age of the sun derived from helioseismology within the formal similar to 1% uncertainty of the latter. Meteorite ages also provide no evidence for a decrease of decay rates with heliocentric distance for nuclides such as Rb-87 (decay mode beta(-) )K-40 (beta(-) and electron capture), and Sm-147 (alpha). 2014 Elsevier B.V. All rights reserved.
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| 36. |
- Meier, Silvio R., 1990-
(författare)
-
Preclinical PET imaging and therapy of Alzheimer's disease
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. To date, there is no treatment available that stops the underlying mechanisms of the disease, but several new drug candidates entered clinical trials every year during the last decade. New treatments, aiming to clear Aβ from the brain parenchyma or to reduce Aβ production, are dependent on diagnostic tools to follow changes in brain Aβ pathology in vivo. The presence of brain amyloid, verified with positron emission tomography (PET), is a regularly used criterion for enrolling patients in clinical trials. However, current amyloid radioligands such as [11C]Pittsburgh Compound B ([11C]PiB) have some disadvantages, e.g. early saturation during disease progression and reduced binding to diffuse Aβ pathology. Currently available radioligands for imaging of neuroinflammation are also suboptimal. In this thesis, we investigated the potential of a brain-penetrating, bispecific Aβ antibody as a PET ligand to detect effects of treatment. In paper I and II, we demonstrated that this ligand can follow Aβ disease progression and that Aβ reduction due to treatment with a BACE-1 inhibitor can be quantified in a mouse model of AD. In paper II we also compared antibody-PET with [11C]PiB-PET and showed that the two ligands provided differing read-outs.In paper III we created and investigated an antibody-based radioligand against the triggering receptor expressed on myeloid cells 2. Compared to wild type mice, transgenic animals displayed higher total in vivo exposure, calculated as the area under the concentration curve based on PET at 24 h, 48 h and 72 h post injection. However, differences were not evident in single time point PET images.In paper IV we investigated brain delivery of a nanobody against GFAP with and without active transcytosis over the blood-brain barrier in vivo. Brain uptake with active transcytosis was two times higher. However, brain retention after 8 h, 24 h or 48 h did not differ between transgenic and wild type mice. In paper V we studied the potential of a hexavalent and bispecific antibody construct against soluble Aβ aggregates for PET or immunotherapy in vivo. Its brain retention increased with age when applied at tracer doses in genetically modified mice. However, when applied at therapeutic dose, it had no or very low impact on Aβ levels measured in brain homogenates.
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| 37. |
- Mohammed Taha, Hiba, et al.
(författare)
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The NORMAN Suspect List Exchange (NORMAN-SLE) : facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry
- 2022
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Ingår i: Environmental Sciences Europe. - : Springer. - 2190-4707 .- 2190-4715. ; 34:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The NORMAN Association (https://www.norman-network.com/) initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for “suspect screening” lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide.Results: The NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The individual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community (https://zenodo.org/communities/norman-sle), with a total of > 40,000 unique views, > 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem (https://pubchem.ncbi.nlm.nih.gov/) and the US EPA’s CompTox Chemicals Dashboard (https://comptox.epa.gov/dashboard/), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101).Conclusions: The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the “one substance, one assessment” approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website (https://www.norman-network.com/nds/SLE/).
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| 38. |
- Moros, Matthias, et al.
(författare)
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Giant saltwater inflow in AD 1951 triggered Baltic Sea hypoxia
- 2024
-
Ingår i: Boreas. - : John Wiley & Sons. - 0300-9483 .- 1502-3885. ; 53:2, s. 125-138
-
Tidskriftsartikel (refereegranskat)abstract
- A marked sedimentological change in subsurface sediments from the entire Baltic Proper, the Baltic Sea, has been previously noted. Our detailed work on a variety of multi-cores from basin-wide transects indicates that this sedimentological change was caused by a large shift in environmental conditions during the 1950s. Until the 1950s, the water column was rather weakly stratified and winter-time convection - although weakened during the post Little Ice Age warming - was still able to ventilate the bottom waters of the Baltic Proper. Therefore, complete sediment sequences only accumulated in calm waters deeper than 150-160 m. High-resolution benthic foraminiferal records of subsurface sediments obtained along the saline water inflow pathway in combination with historical data indicate that the depositional environment changed drastically owing to the giant saline water inflow in AD 1951. The accompanied sharpening of the halo(pycno)cline triggered a collapse in the ventilation of the basin, resulting in oxygen-deficient bottom waters. This deficiency, in turn, caused the onset of phosphate release from the sediments, which accelerated primary production. The ventilation collapse also enabled the onset of deposition of organic carbon-rich sediments also in shallower water areas as calm conditions prevailed up to the modern winter mixing depth (60-70 m). A slight return to Little Ice Age-type conditions was observed during the late 1980s when temperatures decreased and stratification weakened. These conditions gave rise to a reduction in hypoxic areas and to a bottom-water ventilation, most pronounced in the north of the so-called Baltic Sea Klint, a hydrographic and topographic barrier. However, the general environmental conditions essentially have not changed since the 1950s. Remarkably, external (temperature and stratification) in combination with internal factors (e.g. ventilation collapse and phosphate release) were able to change the redox conditions of the Baltic Proper from oxic to hypoxic within less than 10 years. A marked sedimentological change seen in sub-recent seabed sediment cores from the entire Baltic proper can be attributed to large hydrographic and environmental changes that started at the end of the Little Ice Age and were accelerated by a rapid change in stratification resulting from the massive inflow of saline water in AD 1951. The increase in stratification caused a collapse of the already weakened vertical winter-time deep water convection leading to hypoxia in the bottom waters, which in turn forced a sudden phosphate release from the sediments and increased primary production in the late 1950s.image
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| 39. |
- Moros, Matthias, et al.
(författare)
-
Is 'deep-water formation' in the Baltic Sea a key to understanding seabed dynamics and ventilation changes over the past 7,000 years?
- 2020
-
Ingår i: Quaternary International. - : Elsevier BV. - 1040-6182 .- 1873-4553. ; 550, s. 55-65
-
Tidskriftsartikel (refereegranskat)abstract
- Numerous hydro-acoustic studies of the seabed of the Baltic Sea have revealed the unusual occurrence of sediment contourite drifts and re-suspension at greater water depths. In addition, radiocarbon dating of bulk sediments indicates significant age reversals. We present new geophysical, sediment proxy data (including extensive radiocarbon dating) and hydrographic measurements, which are combined with results of numerous marine geological studies performed during the last decades. These data indicate that a deep-water formation process significantly affected the seabed dynamics during regional climatically cold phases during the last c. 7,000 years. We propose that, during the colder periods (e.g. the Little Ice Age), newly formed bottom waters likely caused widespread re-suspension of organic carbon-rich laminated sediments that were deposited during the preceding warm periods in shallower areas, and this material was transported to and re-deposited in the deeper parts of the Baltic Sea sub-basins. In our scenario, a topographic feature, known as the Baltic Sea Klint, acted as a hydrographic barrier for deep-water formed in the northern Baltic. Thus, during the cold periods increased lateral matter influx from the northern Baltic led to the accumulation of much thicker macroscopically homogenous clayey sediments in sub-basins north of the Klint. Moreover, deep-water formation produced bottom currents that led to the formation of sediment contourite drifts at water depths of> 200 m in the Bothnian Sea, the Aland Deep and northern central Baltic Sea sub-basins. Bottom water ventilation in the Baltic Sea is generally assumed to be determined solely by the inflow of oxygen-rich, saline water from the North Sea, but we challenge this assumption and postulate that deep-water formation is a key process that ventilates the bottom waters of the Baltic Sea during climatically cold periods with substantial implications for its sedimentary archive.
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| 40. |
- Petrovici, Mihai A., et al.
(författare)
-
Characterization and Compensation of Network-Level Anomalies in Mixed-Signal Neuromorphic Modeling Platforms
- 2014
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:10, s. e108590-
-
Tidskriftsartikel (refereegranskat)abstract
- Advancing the size and complexity of neural network models leads to an ever increasing demand for computational resources for their simulation. Neuromorphic devices offer a number of advantages over conventional computing architectures, such as high emulation speed or low power consumption, but this usually comes at the price of reduced configurability and precision. In this article, we investigate the consequences of several such factors that are common to neuromorphic devices, more specifically limited hardware resources, limited parameter configurability and parameter variations due to fixed-pattern noise and trial-to-trial variability. Our final aim is to provide an array of methods for coping with such inevitable distortion mechanisms. As a platform for testing our proposed strategies, we use an executable system specification (ESS) of the BrainScaleS neuromorphic system, which has been designed as a universal emulation back-end for neuroscientific modeling. We address the most essential limitations of this device in detail and study their effects on three prototypical benchmark network models within a well-defined, systematic workflow. For each network model, we start by defining quantifiable functionality measures by which we then assess the effects of typical hardware-specific distortion mechanisms, both in idealized software simulations and on the ESS. For those effects that cause unacceptable deviations from the original network dynamics, we suggest generic compensation mechanisms and demonstrate their effectiveness. Both the suggested workflow and the investigated compensation mechanisms are largely back-end independent and do not require additional hardware configurability beyond the one required to emulate the benchmark networks in the first place. We hereby provide a generic methodological environment for configurable neuromorphic devices that are targeted at emulating large-scale, functional neural networks.
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| 41. |
- Reufer, Andreas, et al.
(författare)
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A hit-and-run giant impact scenario
- 2012
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Ingår i: Icarus. - : Elsevier BV. - 0019-1035. ; 221:1, s. 296-299
-
Tidskriftsartikel (refereegranskat)abstract
- The formation of the Moon from the debris of a slow and grazing giant impact of a Mars-sized impactor on the proto-Earth (Cameron and Ward [1976]. Lunar Planet. Sci. Conf.; Canup and Asphaug [2001]. Nature 412, 708) is widely accepted today. We present an alternative scenario with a hit-and-run collision (Asphaug [2010]. Chem. Erde 70, 199) with a fractionally increased impact velocity and a steeper impact angle. (C) 2012 Elsevier Inc. All rights reserved.
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| 42. |
- Ronquist, Fredrik, et al.
(författare)
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Completing Linnaeus’s inventory of the Swedish insect fauna: only 5,000 species left?
- 2020
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:3
-
Tidskriftsartikel (refereegranskat)abstract
- Despite more than 250 years of taxonomic research, we still have only a vague idea about the true size and composition of the faunas and floras of the planet. Many biodiversity inventories provide limited insight because they focus on a small taxonomic subsample or a tiny geographic area. Here, we report on the size and composition of the Swedish insect fauna, thought to represent roughly half of the diversity of multicellular life in one of the largest European countries. Our results are based on more than a decade of data from the Swedish Taxonomy Initiative and its massive inventory of the country’s insect fauna, the Swedish Malaise Trap Project The fauna is considered one of the best known in the world, but the initiative has nevertheless revealed a surprising amount of hidden diversity: more than 3,000 new species (301 new to science) have been documented so far. Here, we use three independent methods to analyze the true size and composition of the fauna at the family or subfamily level: (1) assessments by experts who have been working on the most poorly known groups in the fauna; (2) estimates based on the proportion of new species discovered in the Malaise trap inventory; and (3) extrapolations based on species abundance and incidence data from the inventory. For the last method, we develop a new estimator, the combined non-parametric estimator, which we show is less sensitive to poor coverage of the species pool than other popular estimators. The three methods converge on similar estimates of the size and composition of the fauna, suggesting that it comprises around 33,000 species. Of those, 8,600 (26%) were unknown at the start of the inventory and 5,000 (15%) still await discovery. We analyze the taxonomic and ecological composition of the estimated fauna, and show that most of the new species belong to Hymenoptera and Diptera groups that are decomposers or parasitoids. Thus, current knowledge of the Swedish insect fauna is strongly biased taxonomically and ecologically, and we show that similar but even stronger biases have distorted our understanding of the fauna in the past. We analyze latitudinal gradients in the size and composition of known European insect faunas and show that several of the patterns contradict the Swedish data, presumably due to similar knowledge biases. Addressing these biases is critical in understanding insect biomes and the ecosystem services they provide. Our results emphasize the need to broaden the taxonomic scope of current insect monitoring efforts, a task that is all the more urgent as recent studies indicate a possible worldwide decline in insect faunas.
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| 43. |
- Schmitz, Birger, et al.
(författare)
-
A fossil winonaite-like meteorite in Ordovician limestone: A piece of the impactor that broke up the L-chondrite parent body?
- 2014
-
Ingår i: Earth and Planetary Science Letters. - : Elsevier BV. - 1385-013X .- 0012-821X. ; 400, s. 145-152
-
Tidskriftsartikel (refereegranskat)abstract
- About a quarter of all meteorites falling on Earth today originate from the breakup of the L-chondrite parent body similar to 470 Ma ago, the largest documented breakup in the asteroid belt in the past similar to 3 Ga. A window into the flux of meteorites to Earth shortly after this event comes from the recovery of about 100 fossil L chondrites (1-21 cm in diameter) in a quarry of mid-Ordovician limestone in southern Sweden. Here we report on the first non-L-chondritic meteorite from the quarry, an 8 cm large winonaite-related meteorite of a type not known among present-day meteorite falls and finds. The noble gas data for relict spinels recovered from the meteorite show that it may be a remnant of the body that hit and broke up the L-chondrite parent body, creating one of the major asteroid families in the asteroid belt. After two decades of systematic recovery of fossil meteorites and relict extraterrestrial spinel grains from marine limestone, it appears that the meteorite flux to Earth in the mid-Ordovician was very different from that of today. (C) 2014 The Authors. Published by Elsevier B.V.
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| 44. |
- Schmitz, Birger, et al.
(författare)
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Determining the impactor of the Ordovician Lockne crater: Oxygen and neon isotopes in chromite versus sedimentary PGE signatures
- 2011
-
Ingår i: Earth and Planetary Science Letters. - : Elsevier BV. - 1385-013X .- 0012-821X. ; 306:3-4, s. 149-155
-
Tidskriftsartikel (refereegranskat)abstract
- Abundant chromite grains with L-chondritic composition in the resurge deposits of the Lockne impact crater (458 Myr old: dia. similar to 10 km) in Sweden have been inferred to represent relict fragments of an impactor from the break-up of the L-chondrite parent body at 470 Ma. This view has been challenged based on It/Cr and platinum group element (PGE) patterns of the same resurge deposits, and a reinterpretation of the origin of the chromite grains. An impactor of the non-magmatic iron meteorite type was proposed instead. Here we show that single-grain oxygen and noble-gas isotope analyses of the chromite grains from the resurge deposits further support an origin from an L-chondritic asteroid. We also present PGE analyses and Ir/Cr ratios for fossil L-chondritic meteorites found in mid-Ordovician marine limestone in Sweden. The L-chondritic origin has been confirmed by several independent methods, including major element and oxygen isotopic analyses of chromite. Although the meteorites show the same order-of-magnitude PGE and Cr concentrations as recent L chondrites, the elements have been redistributed to the extent that it is problematic to establish the original meteorite type from these proxies. Different PGE data processing approaches can lead to highly variable results, as also shown here for the Lockne resurge deposits. We conclude that the Lockne crater was formed by an L-chondritic impactor, and that considerable care must be taken when inferring projectile type from PGEs in sedimentary ejecta deposits. (C) 2011 Elsevier B.V. All rights reserved.
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| 45. |
- Schmitz, Birger, et al.
(författare)
-
The micrometeorite flux to Earth during the Frasnian–Famennian transition reconstructed in the Coumiac GSSP section, France
- 2019
-
Ingår i: Earth and Planetary Science Letters. - : Elsevier BV. - 0012-821X. ; 522, s. 234-243
-
Tidskriftsartikel (refereegranskat)abstract
- We have reconstructed the distribution of extraterrestrial chrome spinels in a marine limestone section across the Frasnian–Famennian stratotype section at Coumiac in southern France, providing the first insights on the types of micrometeorites and meteorites that fell on Earth at this time. The data can test whether the small cluster of roughly coeval, large impact structures is related to an asteroid breakup and shower with possible bearings also on the late Devonian biodiversity crisis. A total of ∼180 extraterrestrial spinel grains (>32 μm) were recovered from 957 kg of rock. Noble-gas measurements of individual grains show high solar-wind content, implying an origin from decomposed micrometeorites. Element analyses indicate a marked dominance of ordinary chondritic over achondritic grains, similar to the recent flux. The relation between H, L and LL meteorites is ∼29–58–13%, similar to the late Silurian flux, ∼31–63–6%, but different from the distribution, ∼45–45–10%, in the recent and the Cretaceous flux. Our data show no indication of a generally enhanced late Devonian micrometeorite flux that would accompany an asteroid shower. However, in a single limestone bed that formed immediately before the Upper Kellwasser horizon, that represents the main end-Frasnian species-turnover event, we found an enrichment of ∼10 ordinary chondritic grains (>63 μm) per 100 kg of rock, compared to the ∼1–3 grains per 100 kg that characterise background. The anomalously abundant grains are of mixed H, L and LL types and may be related to an enhanced flux of extraterrestrial dust during postulated minima in both the 405 ka and 2.4 Ma Earth-orbit eccentricity cycles at the onset of the Upper Kellwasser event. In the present solar system the dust accretion at Earth is the highest at eccentricity minima because of the spatial distribution of dust bands of the zodiacal cloud. Besides this small grain anomaly the data here and in previous studies support a stable meteorite flux through the late Silurian and Devonian, in contrast to the mid-Ordovician, when achondritic meteorites that are rare on Earth today were common, followed by the influx of a flood of debris related to the breakup of the L-chondrite parent body. Our accumulated data for six time windows through the Phanerozoic indicate that the ordinary chondrites make up a major fraction in the meteorite flux since at least the mid-Ordovician. We note that the sources in the asteroid belt of the H and L meteorites, the two most common types of meteorites today and through much of the Phanerozoic, remain elusive.
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| 46. |
- Schuetz, Anne K., et al.
(författare)
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Binding of Polythiophenes to Amyloids : Structural Mapping of the Pharmacophore
- 2018
-
Ingår i: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 9:3, s. 475-481
-
Tidskriftsartikel (refereegranskat)abstract
- Luminescent conjugated polythiophenes bind to amyloid proteins with high affinity. Their fluorescence properties, which are modulated by the detailed conformation in the bound state, are highly sensitive to structural features of the amyloid. Polythiophenes therefore represent diagnostic markers for the detection and differentiation of pathological amyloid aggregates. 560 We clarify the binding site and mode of two different polythiophenes to fibrils of the prion domain of the HET-s protein by solid-state NMR and correlate these findings with their fluorescence properties. We demonstrate how amyloid dyes recognize distinct binding sites with specific topological features. Regularly spaced surface charge patterns and well-accessible grooves on the fibril surface define the pharmacophore of the amyloid, which in turn determines the binding mode and fluorescence wavelength of the polythiophene.
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| 47. |
- Vernet, Nicolas, et al.
(författare)
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Experimental determination of the permeability of engineering textiles : Benchmark II
- 2014
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Ingår i: Composites. Part A, Applied science and manufacturing. - : Elsevier Ltd. - 1359-835X .- 1878-5840. ; 61, s. 172-184
-
Tidskriftsartikel (refereegranskat)abstract
- In this second international permeability benchmark, the in-plane permeability values of a carbon fabric were studied by twelve research groups worldwide. One participant also investigated the deformation of the tested carbon fabric. The aim of this work was to obtain comparable results in order to make a step toward standardization of permeability measurements. Unidirectional injections were thus conducted to determine the unsaturated in-plane permeability tensor of the fabric. Procedures used by participants were specified in the guidelines defined for this benchmark. Participants were asked to use the same values for parameters such as fiber volume fraction, injection pressure and fluid viscosity to minimize sources of scatter. The comparison of the results from each participant was encouraging. The scatter between data obtained while respecting the guidelines was below 25%. However, a higher dispersion was observed when some parameters differed from the recommendations of this exercise.
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| 48. |
- Vu Trung, Kien, et al.
(författare)
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Endoscopic papillectomy for ampullary lesions of minor papilla
- 2024
-
Ingår i: Gastrointestinal Endoscopy. - 0016-5107. ; 99:4, s. 587-595.e1
-
Tidskriftsartikel (refereegranskat)abstract
- Background and Aims: Ampullary lesions (ALs) of the minor duodenal papilla are extremely rare. Endoscopic papillectomy (EP) is a routinely used treatment for AL of the major duodenal papilla, but the role of EP for minor AL has not been accurately studied. Methods: We identified 20 patients with ALs of minor duodenal papilla in the multicentric database from the Endoscopic Papillectomy vs Surgical Ampullectomy vs Pancreatitcoduodenectomy for Ampullary Neoplasm study, which included 1422 EPs. We used propensity score matching (nearest-neighbor method) to match these cases with ALs of the major duodenal papilla based on age, sex, histologic subtype, and size of the lesion in a 1:2 ratio. Cohorts were compared by means of chi-square or Fisher exact test as well as Mann-Whitney U test. Results: Propensity score–based matching identified a cohort of 60 (minor papilla 20, major papilla 40) patients with similar baseline characteristics. The most common histologic subtype of lesions of minor papilla was an ampullary adenoma in 12 patients (3 low-grade dysplasia and 9 high-grade dysplasia). Five patients revealed nonneoplastic lesions. Invasive cancer (T1a), adenomyoma, and neuroendocrine neoplasia were each found in 1 case. The rate of complete resection, en-bloc resection, and recurrences were similar between the groups. There were no severe adverse events after EP of lesions of minor papilla. One patient had delayed bleeding that could be treated by endoscopic hemostasis, and 2 patients showed a recurrence in surveillance endoscopy after a median follow-up of 21 months (interquartile range, 12-50 months). Conclusions: EP is safe and effective in ALs of the minor duodenal papilla. Such lesions could be managed according to guidelines for EP of major duodenal papilla.
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| 49. |
- Zhou Hagström, Nanna, 1993-, et al.
(författare)
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Megahertz-rate Ultrafast X-ray Scattering and Holographic Imaging at the European XFEL
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The advent of X-ray free-electron lasers (XFELs) has revolutionized fundamental science, from atomic to condensed matter physics, from chemistry to biology, giving researchers access to X-rays with unprecedented brightness, coherence, and pulse duration. All XFEL facilities built until recently provided X-ray pulses at a relatively low repetition rate, with limited data statistics. Here, we present the results from the first megahertz repetition rate X-ray scattering experiments at the Spectroscopy and Coherent Scattering (SCS) instrument of the European XFEL. We illustrate the experimental capabilities that the SCS instrument offers, resulting from the operation at MHz repetition rates and the availability of the novel DSSC 2D imaging detector. Time-resolved magnetic X-ray scattering and holographic imaging experiments in solid state samples were chosen as representative examples, providing an ideal test-bed for operation at megahertz rates. Nevertheless, our results are relevant and applicable to any other non-destructive XFEL experiments in the soft X-ray range.
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| 50. |
- Zhou Hagström, Nanna, 1993-, et al.
(författare)
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Megahertz-rate ultrafast X-ray scattering and holographic imaging at the European XFEL
- 2022
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Ingår i: Journal of Synchrotron Radiation. - : International Union of Crystallography (IUCr). - 0909-0495 .- 1600-5775. ; 29, s. 1454-1464
-
Tidskriftsartikel (refereegranskat)abstract
- The advent of X-ray free-electron lasers (XFELs) has revolutionized fundamental science, from atomic to condensed matter physics, from chemistry to biology, giving researchers access to X-rays with unprecedented brightness, coherence and pulse duration. All XFEL facilities built until recently provided X-ray pulses at a relatively low repetition rate, with limited data statistics. Here, results from the first megahertz-repetition-rate X-ray scattering experiments at the Spectroscopy and Coherent Scattering (SCS) instrument of the European XFEL are presented. The experimental capabilities that the SCS instrument offers, resulting from the operation at megahertz repetition rates and the availability of the novel DSSC 2D imaging detector, are illustrated. Time-resolved magnetic X-ray scattering and holographic imaging experiments in solid state samples were chosen as representative, providing an ideal test-bed for operation at megahertz rates. Our results are relevant and applicable to any other non-destructive XFEL experiments in the soft X-ray range.
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