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- Galluzzi, L, et al.
(författare)
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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
- 2020
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Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
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- Eriksson, MJ, et al.
(författare)
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Left atrial mechanics in Type 2 Diabetics
- 2006
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Ingår i: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - 0735-1097. ; 47:4, s. 120A-120A
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Humar, Miha, et al.
(författare)
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Introduction of the COST FP 1303 Cooperative Performance Test
- 2015
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Ingår i: Proceedings of the 46th IRG Annual Meeting.
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Konferensbidrag (refereegranskat)abstract
- COST Action FP 1303 “Performance of bio-based building materials” successfully started in October 2013 and an ambitious program was set up for the four year programme. COST Actions provide an excellent opportunity for collaborative research, e.g. in the frame of Round Robin tests.The idea of this respective test was to distribute a fairly simple test set up to as many places in Europe as possible in order to collect performance data reflecting the range of climatic exposure conditions. Furthermore we wanted to consider performance in its manifold meaning, i.e. optical, aesthetical, moisture and functional performance and durability. In contrast to traditional Round Robin tests aiming on comparative evaluation and validation of results from different test laboratories, this initiative aims on collecting performance data under climatically different exposure conditions. Therefore it was required to provide weather data from the respective test sites to allow establishing relationships between climate conditions and the following measured, which shall be evaluated regularly: decay, discolouration, development of mould and other staining fungi, corrosion, formation of cracks and moisture performance (if data logging device is included). Further details about the test and the first outcomes are presented in this paper.
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- Jarnert, C., et al.
(författare)
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Left atrial velocity vector imaging for the detection and quantification of left ventricular diastolic function in type 2 diabetes
- 2008
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Ingår i: European Journal of Heart Failure. - : Wiley. - 1388-9842. ; 10:11, s. 1080-7
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Tidskriftsartikel (refereegranskat)abstract
- UNLABELLED: Left ventricular (LV) diastolic dysfunction (DD) is diagnosed by Doppler echocardiography (DE) and Tissue Doppler imaging (TDI). Velocity vector imaging (VVI) evaluates myocardial deformation (strain). We studied left atrial (LA) deformation and volumes by VVI in relation to established Doppler-derived indices of LV diastolic function in diabetic patients. MATERIAL: Using DE and TDI , 87 patients (males 49%; age 60+/-7 years) with type 2 diabetes mellitus were classified as having no (n=60), mild (n=13) or moderate (n=14) DD. RESULTS: LA volume was larger in moderate (72.3+/-22.4 ml) than in mild DD (58.8+/-16.1 ml; p=0.01) and no DD (57.9+/-16.0 ml; p=0.01). LA roof strain distinguished no DD from mild and moderate DD (p=0.0073). Systolic LA strain correlated to total emptying fraction (r=0.70, p<0.0001), and inversely to LA volume (r=-0.35, p=0.0009). A cross-validated analysis of no versus mild or moderate DD expressed by LA strain revealed a positive predictive value of 48% and negative of 84%. CONCLUSION: LA strain by VVI is impaired in patients with type 2 diabetes mellitus and mild or moderate LV DD. LA strain seems of value in distinguishing normal from abnormal diastolic function. VVI offers new information on regional LA function and LA volumes but has too limited discriminative power to detect early LV DD.
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- Lindqvist, M, et al.
(författare)
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Hemodynamic and sympathoadrenal responses to mental stress during nitric oxide synthesis inhibition
- 2004
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Ingår i: American journal of physiology. Heart and circulatory physiology. - : American Physiological Society. - 0363-6135 .- 1522-1539. ; 287:5, s. H2309-H2315
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Tidskriftsartikel (refereegranskat)abstract
- Cardiovascular and sympathoadrenal responses to a reproducible mental stress test were investigated in eight healthy young men before and during intravenous infusion of the nitric oxide (NO) synthesis inhibitor N-monomethyl-l-arginine (l-NMMA). Before l-NMMA, stress responses included significant increases in heart rate, mean arterial pressure, and cardiac output (CO) and decreases in systemic and forearm vascular resistance. Arterial plasma norepinephrine (NE) increased. At rest after 30 min of infusion of l-NMMA (0.3 mg·kg−1·min−1 iv), mean arterial pressure increased from 98 ± 4 to 108 ± 3 mmHg ( P < 0.001) because of an increase in systemic vascular resistance from 12.9 ± 0.5 to 18.5 ± 0.9 units ( P < 0.001). CO decreased from 7.7 ± 0.4 to 5.9 ± 0.3 l/min ( P < 0.01). Arterial plasma NE decreased from 2.08 ± 0.16 to 1.47 ± 0.14 nmol/l. Repeated mental stress during continued infusion of l-NMMA (0.15 mg·kg−1·min−1) induced qualitatively similar cardiovascular responses, but there was a marked attenuation of the increase in mean arterial blood pressure, resulting in similar “steady-state” blood pressures during mental stress without and with NO blockade. Increases in heart rate and CO were attenuated, but stress-induced decreases in systemic and forearm vascular resistance were essentially unchanged. Arterial plasma NE increased less than during the first stress test. Thus the increased arterial tone at rest during l-NMMA infusion is compensated for by attenuated increases in blood pressure during mental stress, mainly through a markedly attenuated CO response and suppressed sympathetic nerve activity.
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- Melcher, Frank, et al.
(författare)
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The Haidbach deposit in the Central Tauern Window, Eastern Alps, Austria : a metamorphosed orthomagmatic Ni-Cu-Co-PGE mineralization in the Polymetallic Ore District Venediger Nappe System – Hollersbach Complex
- 2021
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Ingår i: Austrian Journal of Earth Sciences. - : Walter de Gruyter. - 0251-7493 .- 2072-7151. ; 114:1, s. 1-26
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Tidskriftsartikel (refereegranskat)abstract
- Cu-Ni-Co-PGE mineralization occurs at Haidbachgraben in the Early Palaeozoic, Subpenninic Hollersbach Complex of the Central Tauern Window, Austria. Massive sulfide ore formed from sulfide melt segregated from silicate melt during intrusion of pyroxenite into magmatic rocks formed in an MORB-type environment. Relics of magmatic minerals include chromian spinel and polyphase sulfide droplets composed of pyrrhotite, chalcopyrite and pentlandite preserved in recrystallized pyrite. Both ore and host rocks were multiply deformed and metamorphosed, leading to hornblendite carrying the ore, enveloped by chlorite-epidote schist. Conditions of – likely Variscan – amphibolite facies metamorphism are documented by relict pargasitic cores in hornblende and actinolite-tremolite, and by ternary sulfarsenide compositions in the Co-Ni-Fe solid solution series that are the most common accessory minerals found in the sulfide ore. Pyrrhotite, pentlandite, chalcopyrite and pyrite are the major sulfide minerals. Chalcopyrite is Cd-rich and retains a high-temperature magmatic signature. High Co/Sb and moderate Se/As ratios in pyrite also point to a magmatic environment of mineralization. The accessory mineral assemblage of small grain size (mostly <10 µm) comprises native Au-Ag alloy and petzite as Au-Ag minerals, sperrylite, a variety of Pd tellurides and bismuthotellurides with elevated Sb, irarsite, and Re sulfides such as tarkianite and a Pb-Re sulfide. In addition, minor molybdenite, bournonite, scheelite and selenides have been identified. Two precious metal assemblages are present in individual samples: (1) hessite associated with Pd tellurides, often accompanied by sphalerite and chalcopyrite; (2) tarkianite forming euhedral inclusions in pyrite. Sperrylite and Au-Ag native alloys are present throughout and were also detected in silicate matrix. Most of the precious metal-bearing phases must have formed during recrystallization of base metal sulfides after the magmatic, and probably during later metamorphic events terminating in the Neoalpine Tauern crystallization.
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