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| 4. |
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| 5. |
- Kristanl, Matej, et al.
(författare)
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The Seventh Visual Object Tracking VOT2019 Challenge Results
- 2019
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Ingår i: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 6. |
- Meng, Mei, et al.
(författare)
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Accumulation of total mercury and methylmercury in rice plants collected from different mining areas in China
- 2014
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Ingår i: Environmental Pollution. - : Pergamon Press. - 0269-7491 .- 1873-6424. ; 184, s. 179-186
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Tidskriftsartikel (refereegranskat)abstract
- A total of 155 rice plants were collected from ten mining areas in three provinces of China (Hunan, Guizhou and Guangdong), where most of mercury (Hg) mining takes place in China. During the harvest season, whole rice plants were sampled and divided into root, stalk & leaf, husk and seed (brown rice), together with soil from root zone. Although the degree of Hg contamination varied significantly among different mining areas, rice seed showed the highest ability for methylmercury (MeHg) accumulation. Both concentrations of total mercury (THg) and MeHg in rice plants were significantly correlated with Hg levels in soil, indicating soil is still an important source for both inorganic mercury (IHg) and MeHg in rice plants. The obvious discrepancy between the distribution patterns of THg and MeHg reflected different pathways of IHg and MeHg accumulation. Water soluble Hg may play more important role in MeHg accumulation in rice plants.
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| 7. |
- Meng, Qinglai, et al.
(författare)
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Rapid personalized AMR diagnostics using two-dimensional antibiotic resistance profiling strategy employing a thermometric NDM-1 biosensor
- 2021
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Ingår i: Biosensors and Bioelectronics. - : Elsevier BV. - 0956-5663. ; 193
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Tidskriftsartikel (refereegranskat)abstract
- Antimicrobial resistance (AMR) threatens global public health and modern surgical medicine. Expression of β-lactamase genes is the major mechanism by which pathogens become antibiotic resistant. Pathogens expressing extended spectrum β-lactamases (ESBL) and carbapenemases (CP) are especially difficult to treat and are associated with increased hospitalization and mortality rates. Despite considerable effort, identification of ESBLs and CPs in a clinically relevant timeframe remains challenging. In this study, a two-dimensional AMR profiling assay strategy was developed employing panels of antibiotics (penicillins, cephamycins, oximino-cephalosporins and carbapenems) and β-lactamases inhibitors (avibactam and EDTA). The assay required the development of a novel biosensor that employed New Delhi metallo-β-lactamase-1 (NDM-1) as the sensing element. Functionally probing β-lactamase activity using substrates and inhibitors combinatorically increased the informational content that enabled the development of assays capable of simultaneous, differential identification of multiple β-lactamases expressed in a single bacterial isolate. More specifically, the assay enabled the simultaneous identification of ESBL and CP in mock samples, as well as in an engineered construct which co-expressed these β-lactamases. The NDM-1 biosensor assay was 16 times and 8 times more sensitive than the ESBL Nordmann/Dortet/Poirel (NDP) and Carba Nordmann/Poirel (NP) assays, respectively. In a retrospective study, NDM-1 biosensor assays were able to differentially identify ESBLs, metallo-CPs and serine-CPs β-lactamases in 23 clinical isolates with 100% accuracy. An assay algorithm was developed which accelerated data analytics reducing turnaround to <1 h. The assay strategy integrated with AI-based data analytics has the potential to provide physicians with a comprehensive readout of patient AMR status.
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| 8. |
- Wei, Wendong, et al.
(författare)
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Embodied greenhouse gas emissions from building China's large-scale power transmission infrastructure
- 2021
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Ingår i: Nature Sustainability. - : NATURE RESEARCH. - 2398-9629. ; 4:8, s. 739-747
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Tidskriftsartikel (refereegranskat)abstract
- China has built the world's largest power transmission infrastructure by consuming massive volumes of greenhouse gas-(GHG-) intensive products such as steel. A quantitative analysis of the carbon implications of expanding the transmission infrastructure would shed light on the trade-offs among three connected dimensions of sustainable development, namely, climate change mitigation, energy access and infrastructure development. By collecting a high-resolution inventory, we developed an assessment framework of, and analysed, the GHG emissions caused by China's power transmission infrastructure construction during 1990-2017. We show that cumulative embodied GHG emissions have dramatically increased by more than 7.3 times those in 1990, reaching 0.89 GtCO(2)-equivalent in 2017. Over the same period, the gaps between the well-developed eastern and less-developed western regions in China have gradually narrowed. Voltage class, transmission-line length and terrain were important factors that influenced embodied GHG emissions. We discuss measures for the mitigation of GHG emissions from power transmission development that can inform global low-carbon infrastructure transitions.
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| 9. |
- Abdoullaye, Doukary, et al.
(författare)
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Permanent genetic resources added to molecular ecology resources database 1 August 2009 - 30 September 2009
- 2010
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Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 10:1, s. 232-236
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Tidskriftsartikel (refereegranskat)abstract
- This article documents the addition of 238 microsatellite marker loci and 72 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Adelges tsugae, Artemisia tridentata, Astroides calycularis, Azorella selago, Botryllus schlosseri, Botrylloides violaceus, Cardiocrinum cordatum var. glehnii, Campylopterus curvipennis, Colocasia esculenta, Cynomys ludovicianus, Cynomys leucurus, Cynomys gunnisoni, Epinephelus coioides, Eunicella singularis, Gammarus pulex, Homoeosoma nebulella, Hyla squirella, Lateolabrax japonicus, Mastomys erythroleucus, Pararge aegeria, Pardosa sierra, Phoenicopterus ruber ruber and Silene latifolia. These loci were cross-tested on the following species: Adelges abietis, Adelges cooleyi, Adelges piceae, Pineus pini, Pineus strobi, Tubastrea micrantha, three other Tubastrea species, Botrylloides fuscus, Botrylloides simodensis, Campylopterus hemileucurus, Campylopterus rufus, Campylopterus largipennis, Campylopterus villaviscensio, Phaethornis longuemareus, Florisuga mellivora, Lampornis amethystinus, Amazilia cyanocephala, Archilochus colubris, Epinephelus lanceolatus, Epinephelus fuscoguttatus, Symbiodinium temperate-A clade, Gammarus fossarum, Gammarus roeselii, Dikerogammarus villosus and Limnomysis benedeni. This article also documents the addition of 72 sequencing primer pairs and 52 allele specific primers for Neophocaena phocaenoides.
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| 10. |
- Adlerberth, Josefin, et al.
(författare)
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Thermometric analysis of blood metabolites in ICU patients
- 2020
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Ingår i: Journal of Thermal Analysis and Calorimetry. - : Springer Science and Business Media LLC. - 1388-6150 .- 1588-2926. ; 140:2, s. 763-771
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Tidskriftsartikel (refereegranskat)abstract
- Real-time monitoring of patient’s blood metabolites, such as glucose and lactate, could potentially improve surgery and recovery outcomes for patients in surgical and intensive care units. Our enzyme thermometric biosensor which is based on flow injected calorimetric determination of immobilized enzyme reaction is capable of performing continuous, fast, and quantitative analysis of metabolites using whole blood. A key technical advantage the assay affords is the ability to use unpretreated whole blood. In this article, the enzyme thermometric biosensor was used, for the first time, to determine glucose and lactate concentrations in the blood of ICU patients. The linear detection range for glucose was 0.5–30 mM and 0.25–12 mM for lactate, using a 20 μL sample volume. A maximum sampling rate of 15 measurements per hour was achieved using venous blood samples, which corresponds to a 4-min measurement interval. In order to validate the accuracy of the results, a comparative analysis between the thermometric biosensor and the clinically applied instrument (LifeScan’s OneTouch®) which is based on disposable dry chemical reaction was performed using samples from 33 patients. The results showed a good correlation between the two methods for both glucose (r = 0.843, p < 0.0001) and lactate (r = 0.78, p = 0.0105). The ability to monitor metabolite levels and trends on a clinically relevant timescale of 5 min is critical for intensive monitoring of ICP and operative patients.
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| 11. |
- An, Dong, et al.
(författare)
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NIR-II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy : Recent Advances and Future Challenges
- 2021
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Ingår i: Advanced Functional Materials. - : John Wiley & Sons. - 1616-301X .- 1616-3028. ; 31:32
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Forskningsöversikt (refereegranskat)abstract
- Non-invasive cancer photothermal therapy (PTT) is a promising replacement for traditional cancer treatments. The second near-infrared region induced PTT (NIR-II PTT, 1000-1500 nm) with less energy dissipation has been developed for deeper-seated tumor treatment in recent years compared with the traditional first near-infrared light (750-1000 nm). In addition, the use of emerging inorganic 2D nanomaterials as photothermal agents (PTAs) further enhanced PTT efficiency due to their intrinsic photothermal properties. NIR-II light stimulated inorganic 2D nanomaterials for PTT is becoming a hot topic in both academic and clinical fields. This review summarizes the categories, structures, and photothermal conversion properties of inorganic 2D nanomaterials for the first time. The recent synergistic strategies of NIR-II responsive PTT combined with other treatment approaches including chemotherapy, chemodynamic therapy, photodynamic therapy, radiotherapy are summarized. The future challenges and perspectives on these 2D nanomaterials for NIR-II responsive PTT systems construction are further discussed.
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| 12. |
- Anderson, Cynthia M., et al.
(författare)
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Permanent Genetic Resources added to Molecular Ecology Resources Database 1 December 2009-31 January 2010
- 2010
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Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 10:3, s. 576-579
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Tidskriftsartikel (refereegranskat)abstract
- This article documents the addition of 220 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Allanblackia floribunda, Amblyraja radiata, Bactrocera cucurbitae, Brachycaudus helichrysi, Calopogonium mucunoides, Dissodactylus primitivus, Elodea canadensis, Ephydatia fluviatilis, Galapaganus howdenae howdenae, Hoplostethus atlanticus, Ischnura elegans, Larimichthys polyactis, Opheodrys vernalis, Pelteobagrus fulvidraco, Phragmidium violaceum, Pistacia vera, and Thunnus thynnus. These loci were cross-tested on the following species: Allanblackia gabonensis, Allanblackia stanerana, Neoceratitis cyanescens, Dacus ciliatus, Dacus demmerezi, Bactrocera zonata, Ceratitis capitata, Ceratitis rosa, Ceratits catoirii, Dacus punctatifrons, Ephydatia mulleri, Spongilla lacustris, Geodia cydonium, Axinella sp., Ischnura graellsii, Ischnura ramburii, Ischnura pumilio, Pistacia integerrima and Pistacia terebinthus.
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| 13. |
- Chen, Zhan Ming, et al.
(författare)
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Consumption-based greenhouse gas emissions accounting with capital stock change highlights dynamics of fast-developing countries
- 2018
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Traditional consumption-based greenhouse gas emissions accounting attributed the gap between consumption-based and production-based emissions to international trade. Yet few attempts have analyzed the temporal deviation between current emissions and future consumption, which can be explained through changes in capital stock. Here we develop a dynamic model to incorporate capital stock change in consumption-based accounting. The new model is applied using global data for 1995–2009. Our results show that global emissions embodied in consumption determined by the new model are smaller than those obtained from the traditional model. The emissions embodied in global capital stock increased steadily during the period. However, capital plays very different roles in shaping consumption-based emissions for economies with different development characteristics. As a result, the dynamic model yields similar consumption-based emissions estimation for many developed countries comparing with the traditional model, but it highlights the dynamics of fast-developing countries.
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| 14. |
- Fu, Q. X., et al.
(författare)
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Doped ceria-chloride composite electrolyte for intermediate temperature ceramic membrane fuel cells
- 2002
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Ingår i: Materials letters (General ed.). - 0167-577X .- 1873-4979. ; 53:3, s. 186-192
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Tidskriftsartikel (refereegranskat)abstract
- A kind of oxide-salt composite electrolyte, gadolinium-doped ceria (GDC)-LiCl-SrCl2, prepared with hot-press technique, shows superior ionic conductivity, which is 2-10 times higher than that of GDC itself at the temperature range of 400-600 degreesC. More interestingly, not like the GDC electrolyte, which has some extent of electronic conduction under reducing atmosphere, the composite electrolyte is almost a pure ionic conductor, evidenced by the fuel cell's (FC) open circuit voltage (OCV) close to the theoretical one. The fuel cells based on this composite electrolyte show excellent power density output even at temperature as low as 500 degreesC (240 mW cm(-2)) in spite of the relatively thick electrolyte (0.4 mm). Such high performance, in combination with its low cost in both raw materials and fabrication process, make this kind of composite electrolyte a good candidate electrolyte material for future ultra-low-cost intermediate temperature ceramic membrane fuel cells (IT-CMFCs).
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| 15. |
- Fu, Q. X., et al.
(författare)
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Intermediate temperature fuel cells based on doped ceria-LiCl-SrCl2 composite electrolyte
- 2002
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Ingår i: Journal of Power Sources. - 0378-7753 .- 1873-2755. ; 104:1, s. 73-78
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Tidskriftsartikel (refereegranskat)abstract
- A new type of oxide-salt composite electrolyte, gadolinium-doped ceria (GDC)-LiCl-SrCl2, was developed and demonstrated its promising use for intermediate temperature (400-700 degreesC) fuel cells (ITFCs). The dc electrical conductivity of this composite electrolyte (0.09-0.13 S cm(-1) at 500-650 degreesC) was 3-10 times higher than that of the pure GDC electrolyte, indicating remarkable proton or oxygen ion conduction existing in the LiCl-SrCl2 chloride salts or at the interface between GDC and the chloride salts. Using this composite electrolyte, peak power densities of 260 and 510 mW cm(-2), with current densities of 650 and 1250 mA cm(-2) were achieved at 550 and 625 degreesC, respectively. This makes the new material a good candidate electrolyte for future low-cost ITFCs.
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| 16. |
- Ge, ShuCan, et al.
(författare)
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Characteristic analysis of layered PMSEs measured with different elevation angles at VHF based on an experimental case
- 2021
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Ingår i: Earth and Planetary Physics. - : Earth and Planetary Physics. - 2096-3955. ; 5:1, s. 42-51
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Tidskriftsartikel (refereegranskat)abstract
- Polar Mesosphere Summer Echoes (PMSEs) are very strong radar echoes observed at altitudes near the polar summer mesopause. One of the essential properties of these radar echoes is that they can give useful diagnostic information about the physics of the scattering process. In this paper, the related characteristics of PMSEs measured with the European Incoherent SCATter Very High Frequency (EISCAT VHF) 224 MHz radar on 13-15 July 2010 are studied at different elevation angles from 78 degrees to 90 degrees. It is found that the PMSEs peak power and strongest PMSEs average power occur at the same elevation angles. Also interesting is that the strongest PMSEs occur at off-vertical angles when a PMSEs has a layered (multilayer) structure. And reflection may have more significant effects on PMSEs when there are double or multilayer PMSEs. Possible explanations regarding these observations are discussed.
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| 17. |
- Georgiou, Konstantinos, et al.
(författare)
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Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
- 2016
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 127:24, s. 3026-3034
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Tidskriftsartikel (refereegranskat)abstract
- Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBCL. PIM1 and TP63 were also identified as novel translocation partners for PD-L1/PD-L2. Fluorescence in situ hybridization was furthermore used to rapidly screen an expanded DLBCL cohort. Collectively, a subset of samples was found to be affected by gains (12%), amplifications (3%), and translocations (4%) of the PD-L1/PD-L2 locus. RNA sequencing data coupled with immunohistochemistry revealed that these cytogenetic alterations correlated with increased expression of PD-L1 but not of PD-L2. Moreover, cytogenetic alterations affecting the PD-L1/PD-L2 locus were more frequently observed in the non-germinal center B cell-like (non-GCB) subtype of DLBCL. These findings demonstrate the genetic basis of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1-PD-L1/PD-L2 axis might benefit DLBCL patients, especially those belonging to the more aggressive non-GCB subtype.
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| 18. |
- He, Xiaohe, et al.
(författare)
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Real-time regulation of room temperature based on individual thermal sensation using an online brain–computer interface
- 2022
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Ingår i: Indoor Air. - : NLM (Medline). - 0905-6947 .- 1600-0668. ; 32:e13106
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Tidskriftsartikel (refereegranskat)abstract
- Regulation of indoor temperature based on neurophysiological and psychological signals is one of the most promising technologies for intelligent buildings. In this study, we developed a system for closed-loop control of indoor temperature based on brain-computer interface (BCI) technology for the first time. Electroencephalogram (EEG) signals were collected from subjects for two room temperature categories (cool comfortable and hot uncomfortable) and used to build a thermal-sensation discrimination model (TSDM) with an ensemble learning method. Then, an online BCI system was developed based on the TSDM. In the online room temperature control experiment, when the TSDM detected that the subjects felt hot and uncomfortable, BCI would automatically turn on the air conditioner, and when the TSDM detected that the subjects felt cool and comfortable, BCI would automatically turn off the air conditioner. The results of online experiments in a hot environment showed that a BCI could significantly improve the thermal comfort of subjects (the subjective thermal comfort score decreased from 2.45 (hot uncomfortable) to 0.55 (cool comfortable), p < 0.001). A parallel experiment further showed that if the subjects wore thicker clothes during the experiment, the BCI would turn on the air conditioner for a longer time to ensure the thermal comfort of the subjects. This has further confirmed the effectiveness of TSDM model in evaluating thermal sensation under the dynamic change of room temperature and showed the model's good robustness. This study proposed a new paradigm of human-building interaction, which is expected to play a promising role in the development of human-centered intelligent buildings.
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| 19. |
- Hu, Bisong, et al.
(författare)
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Geographical detector-based assessment of multi-level explanatory powers of determinants on China’s medical-service resumption during the COVID-19 epidemic
- 2023
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Ingår i: Environment and Planning B: Urban Analytics and City Science. - : SAGE. - 2399-8083 .- 2399-8091. ; 50:7, s. 1739-1758
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Tidskriftsartikel (refereegranskat)abstract
- Knowing the multi-level influences of determinants on medical-service resumptions is of great benefits to the policymaking for medical-service recovery at different levels of study units during the post-COVID-19 pandemic era. This article evaluated the hospital- and city-level resumptions of medical services in mainland China based on the data of location-based service (LBS) requests of mobile devices during the two time periods (December 2019 and from February 21 to March 18, 2020). We selected medical-service capacity, human movement, epidemic severity, and socioeconomic factors as the potential determinants on medical-service resumptions and then explicitly assessed their multi-level explanatory powers and the interactive effects of paired determinants using the geographical detector method. The results indicate that various determinants had different individual explanatory powers and interactive relationships/effects at different levels of medical-service resumptions. The current study provides a novel multi-level insight for assessing work resumption and individual/interactive influences of determinants, and considerable implications for regionalized recovery strategies of medical services.
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| 20. |
- Hu, Hai-Xi, et al.
(författare)
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Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation
- 2015
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- The one-dimensional pattern of heterocyst in the model cyanobacterium Anabaena sp. PCC 7120 is coordinated by the transcription factor HetR and PatS peptide. Here we report the complex structures of HetR binding to DNA, and its hood domain (HetR(Hood)) binding to a PatS-derived hexapeptide (PatS6) at 2.80 and 2.10 angstrom, respectively. The intertwined HetR dimer possesses a couple of novel HTH motifs, each of which consists of two canonical alpha-helices in the DNA-binding domain and an auxiliary alpha-helix from the flap domain of the neighboring subunit. Two PatS6 peptides bind to the lateral clefts of HetR(Hood), and trigger significant conformational changes of the flap domain, resulting in dissociation of the auxiliary alpha-helix and eventually release of HetR from the DNA major grove. These findings provide the structural insights into a prokaryotic example of Turing model.
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| 21. |
- Huang, He, et al.
(författare)
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Material informatics for uranium-bearing equiatomic disordered solid solution alloys
- 2021
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Ingår i: Materials Today Communications. - : Elsevier BV. - 2352-4928. ; 29
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Tidskriftsartikel (refereegranskat)abstract
- Near-equiatomic, multi-component alloys with disordered solid solution phase (DSSP) are associated with outstanding performance in phase stability, mechanical properties and irradiation resistance, and may provide a feasible solution for developing novel uranium-based alloys with better fuel capacity. In this work, we build a machine learning (ML) model of disordered solid solution alloys (DSSAs) based on about 6000 known multicomponent alloys and several materials descriptors to efficiently predict the DSSAs formation ability. To fully optimize the ML model, we develop a multi-algorithm cross-verification approach in combination with the SHapley Additive exPlanations value (SHAP value). We find that the Delta S-C, Lambda, Phi(s), gamma and 1/Omega, corresponding to the former two Hume - Rothery (H - R) rules, are the most important materials descriptors affecting DSSAs formation ability. When the ML model is applied to the 375 uranium-bearing DSSAs, 190 of them are predicted to be the DSSAs never known before. 20 of these alloys were randomly synthesized and characterized. Our predictions are in-line with experiments with 3 inconsistent cases, suggesting that our strategy offers a fast and accurate way to predict novel multi-component alloys with high DSSAs formation ability. These findings shed considerable light on the mapping between the material descriptors and DSSAs formation ability.
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| 22. |
- Huang, Zi-Nan, et al.
(författare)
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Analysis of the stress field in the reactor vessel of the China Initiative Accelerator Driven System during postulated ULOF and UTOP transients
- 2023
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Ingår i: Annals of Nuclear Energy. - : Elsevier BV. - 0306-4549 .- 1873-2100. ; 194
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Tidskriftsartikel (refereegranskat)abstract
- The China Initiative Accelerator Driven System (CiADS) was proposed by China Academy of Science since 2015. The subcritical reactor in CiADS is a liquid Lead Bismuth Eutectic (LBE) cooled fast reactor. When the reactor core is in operation, the LBE coolant will directly contact and corrode the inner surface of reactor vessel. Due to the high temperature, the corrosion will be more severe. If the stress on the reactor vessel exceeds the limit, the plastic deformation will occur, leading to the generation and expansion of defects and cracks, and the safety of the reactor will be affected. Therefore, evaluating the stress field of the reactor vessel under different operating conditions is a very important research project. In this paper, the finite element analysis software ADINA was applied to analyze the reactor vessel in CiADS, and the ASME Code was used as stress assessment standards. We can preliminarily prove that the stress assessments of the vessel during the postulated Unprotected Loss of Flow (ULOF) accidents satisfy the requirements of ASME Code. The limit reactivity insertion to protect the vessel from plastic deformation is 0.58$ in the postulated Unprotected Transient over Power (UTOP) accidents based on our current results. Therefore, we can preliminarily conclude that the current material selection and structural design of the reactor vessel in CiADS could survive most of the postulated transient accidents considering the stress effect.
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| 23. |
- Kan, Siyi, et al.
(författare)
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Risk of intact forest landscape loss goes beyond global agricultural supply chains
- 2023
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Ingår i: One Earth. - : Elsevier BV. - 2590-3322 .- 2590-3330. ; 6:1, s. 55-65
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Tidskriftsartikel (refereegranskat)abstract
- The continued loss of unfragmented intact forest landscapes (IFLs) despite numerous global conservation initiatives indicates the need for improved knowledge of proximate and underlying drivers. Yet the role of non-agricultural activities in forest degradation and fragmentation has not received adequate attention. We focus on IFL loss caused by various economic activities and investigate the influence of global consumption and trade via the multi-regional input-output model. For IFL loss associated with the 2014 world economy, over 60% was related to final consumption of non-agricultural products. More than one-third of IFL loss was linked to export, primarily from Russia, Canada, and tropical regions to mainland China, the EU, and the United States. Of IFL loss associated with export, 51% and 26% was directly caused by logging and mining or energy extraction, respectively. The dispersed nature of IFL loss drivers and their indirect links to individual final consumers call for stronger government engagement and supply chain interventions.
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| 24. |
- Liu, Jian, et al.
(författare)
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Printable highly conductive conjugated polymer sensitized ZnO NCs as cathode interfacial layer for efficient polymer solar cells
- 2014
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 6:11, s. 8237-8245
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Tidskriftsartikel (refereegranskat)abstract
- We report a facile way to produce printable highly conductive cathode interfacial layer (CIL) for efficient polymer solar cells (PSCs) by sensitizing ZnO nanocrystals (NCs) with a blue fluorescent conjugated polymer, poly(9, 9-bis-(6-diethoxylphosphorylhexyl) fluorene) (PFEP). Herein, PFEP plays dual distinctive roles in the composite. Firstly, PFEP chains can effectively block the aggregation of ZnO NCs, leading to uniform and smooth film during solution processing via assembly on ZnO NC surfaces through their pending phosphonate groups. Secondly, PFEP can greatly improve the conductivity of ZnO NCs by charge transfer doping, that is the charge transfer from the sensitizer driven by electron-chemical potential equilibrium, which could be even more pronounced under light illumination because of light excitation of PFEP sensitizer. The increased conductivity in ZnO-PFEP layer renders more efficient electron transport and extraction compared to pristine ZnO layer. This ZnO-PFEP CIL was successfully applied to PSCs based on three polymer donor systems with different band-gaps, and efficiency enhancements from 44 to 70% were observed compared to those PSCs with pristine ZnO CIL. The highest efficiency of 7.56% was achieved in P(IID-DTC):PC70BM-based PSCs by using ZnO-PFEP film as CIL. Moreover, the enhanced conductivity due to the charge-transfer doping effect allows thick ZnO-PFEP film to be used as CIL in high-performance PSCs. Both the high conductivity and good film-forming properties of ZnO-PFEP CIL are favorable for large-scale printable PSCs, which is also verified by high-efficiency PSCs with ZnO-PFEP CIL fabricated using doctor-blading, a large-scale processing technique. The work provides an efficient printable cathode interfacial material for efficient PSCs.
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| 25. |
- Liu, Shichao, et al.
(författare)
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一种β-内酰胺类抗生素的酶热检测方法
- 2019
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Ingår i: Journal of Shanxi University (Natural Science Edition). ; :2021-02
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Tidskriftsartikel (refereegranskat)abstract
- The penicillinase thermistor biosensor（Penicillinase sensor） was developed for the rapid monitoring of blood penem antibiotics concentration and rapid identification of extraneous penicillinase in milk on site.However, the wide application of the penicillinase thermistor biosensor was limited due to its intrinsic poor activity to hydrolyze cephem and carbapenem antibiotics.The recently identified carbapenemase New Delhi metallo-beta-lactamase 1（NDM-1） is able to hydrolyze all commercially available β-lactam antibiotics in high efficacy.We coupled the NDM-1 and the enzymatic thermistor biosensor to develop a NDM-1 thermistor biosensor（NDM-1 sensor） by the installment of the enzymatic thermistor with an enzyme column loaded with NDM-1 conjugated CPG beads.The NDM-1 sensor shows high response activity to Piperacillin（PIP）,Ceftriaxone（CTRX）, and Meropenem（MEM）, and the response activity of the NDM-1 sensor to these three β-lactam antibiotics are all Zn2+ dependent.Moreover, the response activity of the NDM-1 sensor to Penicillin G（P）, PIP, Cefazolin（CZO）, CTRX, Cefepime（FEP） and MEM all linearly correlated with antibiotic concentration from 31.25 to 1 000 mg/L.Within pH from 6.0 to 8.0, the optimal response activity of the NDM-1 sensor to P,PIP, CZO, CTRX and FEP are found at pH 6.5, while the optimal response activity of the NDM-1 sensor to MEM is found at pH8.0.These data indicate that the featured activity of NDM-1 was well maintained after conjugation on CPG beads, and NDM-1 sensor is capable to quantitate three classes of β-lactam antibiotics including penem, cephem and carbapenem within a wide concentration range.
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| 26. |
- Liu, Xintao, 1976-
(författare)
-
The Principle of Scaling of Geographic Space and its Application in Urban Studies
- 2012
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Geographic space is the large-scale and continuous space that encircles the earth and in which human activities occur. The study of geographic space has drawn attention in many different fields and has been applied in a variety of studies, including those on cognition, urban planning and navigation systems. A scaling property indicates that small objects are far more numerous than large ones, i.e., the size of objects is extremely diverse. The concept of scaling resembles a fractal in geometric terms and a power law distribution from the perspective of statistical physics, but it is different from both in terms of application. Combining the concepts of geographic space and scaling, this thesis proposes the concept of the scaling of geographic space, which refers to the phenomenon that small geographic objects or representations are far more numerous than large ones. From the perspectives of statistics and mathematics, the scaling of geographic space can be characterized by the fact that the sizes of geographic objects follow heavy-tailed distributions, i.e., the special non-linear relationships between variables and their probability.In this thesis, the heavy-tailed distributions refer to the power law, lognormal, exponential, power law with an exponential cutoff and stretched exponential. The first three are the basic distributions, and the last two are their degenerate versions. If the measurements of the geographic objects follow a heavy-tailed distribution, then their mean value can divide them into two groups: large ones (a low percentage) whose values lie above the mean value and small ones (a high percentage) whose values lie below. This regularity is termed as the head/tail division rule. That is, a two-tier hierarchical structure can be obtained naturally. The scaling property of geographic space and the head/tail division rule are verified at city and country levels from the perspectives of axial lines and blocks, respectively.In the study of geographic space, the most important concept is geographic representation, which represents or partitions a large-scale geographic space into numerous small pieces, e.g., vector and raster data in conventional spatial analysis. In a different context, each geographic representation possesses different geographic implications and a rich partial knowledge of space. The emergence of geographic information science (GIScience) and volunteered geographic information (VGI) greatly enable the generation of new types of geographic representations. In addition to the old axial lines, this thesis generated several types of representations of geographic space: (a) blocks that were decomposed from road segments, each of which forms a minimum cycle such as city and field blocks (b) natural streets that were generated from street center lines using the Gestalt principle of good continuity; (c) new axial lines that were defined as the least number of individual straight line segments mutually intersected along natural streets; (d) the fewest-turn map direction (route) that possesses the hierarchical structure and indicates the scaling of geographic space; (e) spatio-temporal clusters of the stop points in the trajectories of large-scale floating car data.Based on the generated geographic representations, this thesis further applies the scaling property and the head/tail division rule to these representations for urban studies. First, all of the above geographic representations demonstrate the scaling property, which indicates the scaling of geographic space. Furthermore, the head/tail division rule performs well in obtaining the hierarchical structures of geographic objects. In a sense, the scaling property reveals the hierarchical structures of geographic objects. According to the above analysis and findings, several urban studies are performed as follows: (1) generate new axial lines based on natural streets for a better understanding of urban morphologies; (2) compute the fewest-turn and shortest map direction; (3) identify urban sprawl patches based on the statistics of blocks and natural cities; (4) categorize spatio-temporal clusters of long stop points into hotspots and traffic jams; and (5) perform an across-country comparison of hierarchical spatial structures.The overall contribution of this thesis is first to propose the principle of scaling of geographic space as well as the head/tail division rule, which provide a new and quantitative perspective to efficiently reduce the high degree of complexity and effectively solve the issues in urban studies. Several successful applications prove that the scaling of geographic space and the head/tail division rule are inspiring and can in fact be applied as a universal law, in particular, to urban studies and other fields. The data sets that were generated via an intensive geo-computation process are as large as hundreds of gigabytes and will be of great value to further data mining studies.
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| 27. |
- Liu, Yanyan, et al.
(författare)
-
Industrial grade rare-earth triple-doped ceria applied for advanced low-temperature electrolyte layer-free fuel cells
- 2017
-
Ingår i: International journal of hydrogen energy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0360-3199 .- 1879-3487. ; 42:34, s. 22273-22279
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, the mixed electron-ion conductive nanocomposite of the industrial-grade rare-earth material (Le(3+), Pr3+ and Nd3+ triple-doped ceria oxide, noted as LCPN) and commercial p-type semiconductor Ni0.8Co0.15Al0.05Li-oxide (hereafter referred to as NCAL) were studied and evaluated as a functional semiconductor-ionic conductor layer for the advanced low temperature solid oxide fuel cells (LT-SOFCs) in an electrolyte layer-free fuel cells (EFFCs) configuration. The enhanced electrochemical performance of the EFFCs were analyzed based on the different semiconductor-ionic compositions with various weight ratios of LCPN and NCAL. The morphology and microstructure of the raw material, as prepared LCPN as well the commercial NCAL were investigated and characterized by Xray diffraction (XRD), scanning electron microscope (SEM), and energy-dispersive X-ray spectrometer (EDS), respectively. The EFFC performances and electrochemical properties using the LCPN-NCAL layer with different weight ratios were systematically investigated. The optimal composition for the EFFC performance with 70 wt% LCPN and 30 wt% NCAL displayed a maximum power density of 1187 mW cm(-2) at 550 degrees C with an open circuit voltage (OCV) of 1.07 V. It has been found that the well-balanced electron and ion conductive phases contributed to the good fuel cell performances. This work further promotes the development of the industrial-grade rare-earth materials applying for the LTSOFC technology. It also provides an approach to utilize the natural source into the energy field.
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| 28. |
- Meng, Jie, et al.
(författare)
-
Modulating Charge-Carrier Dynamics in Mn-Doped All-Inorganic Halide Perovskite Quantum Dots through the Doping-Induced Deep Trap States
- 2020
-
Ingår i: The Journal of Physical Chemistry Letters. - : American Chemical Society (ACS). - 1948-7185. ; 11:9, s. 3705-3711
-
Tidskriftsartikel (refereegranskat)abstract
- Transition-metal ion doping has been demonstrated to be effective for tuning the photoluminescence properties of perovskite quantum dots (QDs). However, it would inevitably introduce defects in the lattice. As the Mn concentration increases, the Mn dopant photoluminescence quantum yield (PLQY) first increases and then decreases. Herein the influence of the dopant and the defect states on the photophysics in Mn-doped CsPbCl3 QDs was studied by time-resolved spectroscopies, whereas the energy levels of the possible defect states were analyzed by density functional theory calculations. We reveal the formation of deep interstitials defects (Cli) by Mn2+ doping. The depopulation of initial QD exciton states is a competition between exciton-dopant energy transfer and defect trapping on an early time scale (<100 ps), which determines the final PLQY of the QDs. The present work establishes a robust material optimization guideline for all of the emerging applications where a high PLQY is essential.
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| 29. |
- Meng, Ling-Yan, et al.
(författare)
-
Cellulose-based Nanocarriers as Platforms for Cancer Therapy
- 2017
-
Ingår i: Current pharmaceutical design. - : BENTHAM SCIENCE PUBL LTD. - 1381-6128 .- 1873-4286. ; 23:35, s. 5292-5300
-
Forskningsöversikt (refereegranskat)abstract
- Cellulose is an important environmentally-friendly renewable polymer on the earth. Cellulose has been widely used as feedstocks for the synthesis of biomaterials, biofuels and biochemicals. Recently, cellulose and cellulose derivatives have received intense attention in biomedical applications, such as tissue engineering, scaffold, artificial blood vessel, skin grafts, artificial skin, drug carrier, and chronic skin diseases, many of which are somehow related to cancer therapy. In this mini-review, we focus on the up-to-date development of cellulose-based nanocarriers used for cancer therapy. Various cellulose-based nanocarriers such as bacterial cellulose (BC), cellulose acetate, microcrystalline cellulose, carboxymethyl cellulose, cellulose nanocrystals, cellulose nanofibrills, etc, are reviewed in terms of being used in drug delivery systems for cancer treatment. Different strategies for the synthesis of cellulose-based nanocarriers are summarized. Special attention is paid on the structure and properties of cellulose-based drug carriers for cancer therapy via some representative examples. Finally, the problems and future developments of these promising polymeric nanocarriers are raised and proposed.
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| 30. |
- Meng, Pingping, et al.
(författare)
-
Efficient removal of perfluorooctane sulfonate from aqueous film-forming foam solution by aeration-foam collection
- 2018
-
Ingår i: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 203, s. 263-270
-
Tidskriftsartikel (refereegranskat)abstract
- Aqueous film-forming foams (AFFFs) used in fire-fighting are one of the main contamination sources of perfluorooctane sulfonate (PFOS) to the subterranean environment, requiring high costs for remediation. In this study, a method that combined aeration and foam collection was presented to remove PFOS from a commercially available AFFF solution. The method utilized the strong surfactant properties of PFOS that cause it to be highly enriched at air-water interfaces. With an aeration flow rate of 75 mL/min, PFOS removal percent reached 96% after 2 h, and the PFOS concentration in the collected foam was up to 6.5 mmol/L, beneficial for PFOS recovery and reuse. Increasing the aeration flow rate, ionic strength and concentration of co-existing surfactant, as well as decreasing the initial PFOS concentration, increased the removal percents of PFOS by increasing the foam volume, but reduced the enrichment of PFOS in the foams. With the assistance of a co-existing hydrocarbon surfactant, PFOS removal percent was above 99.9% after aeration-foam collection for 2 h and the enrichment factor exceeded 8400. Aeration-foam collection was less effective for short-chain perfluoroalkyl substances due to their relatively lower surface activity. Aeration-foam collection was found to be effective for the removal of high concentrations of PFOS from AFFF-contaminated wastewater, and the concentrated PFOS in the collected foam can be reused.
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| 31. |
- Meng, Pingping, et al.
(författare)
-
Role of the air-water interface in removing perfluoroalkyl acids from drinking water by activated carbon treatment
- 2020
-
Ingår i: Journal of Hazardous Materials. - : Elsevier BV. - 0304-3894 .- 1873-3336. ; 386
-
Tidskriftsartikel (refereegranskat)abstract
- Contamination of drinking water by per- and polyfluoroalkyl substances (PFASs) is a worldwide problem. In this study, we for the first time revealed the role of the air-water interface in enhancing the removal of long-chain perfluoroalkyl carboxylic (PFCAs; CnF2n+1COOH, n >= 7) and perfluoroalkane sulfonic (PFSAs; CnF2n+1SO3H, n >= 6) acids, collectively termed as perfluoroalkyl acids (PFAAs), through combined aeration and adsorption on two kinds of activated carbon (AC). Aeration was shown to enhance the removal of long-chain PFAAs through adsorption at the air-water interface and subsequent adsorption of PFAA-enriched air bubbles to the AC. The removal of selected long-chain PFAAs was increased by 50-115 % with the assistance of aeration, depending on the perfluoroalkyl chain length. Aeration is more effective in enhancing long-chain PFAA removal as air-water interface adsorption increases with PFAA chain length due to higher surface activity. After removing adsorbed air bubbles by centrifugation, up to 80 % of the long-chain PFAAs were able to desorb from the sorbent, confirming the contribution of the air-water interface to the adsorption of PFAAs on AC. Aeration during AC treatment of water could enhance the removal of long-chain PFAAs, and improve the performance of AC during water treatment.
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| 32. |
- Meng, Qinglai, et al.
(författare)
-
Development of a tRNA-Synthetase Microarray for Protein Analysis
- 2004
-
Ingår i: Sensors and Materials. - 0914-4935. ; 16:8, s. 401-412
-
Tidskriftsartikel (refereegranskat)abstract
- Proteins are composed of 20 different amino acids. In the translation process, each of these 20 amino acids is specifically recognized by their cognate aminoacyl-tRNA synthetase. The fidelity of this recognition system is essential if translation is to function properly. The development of an in vitro system based on this recognition scheme would make a powerful analytical tool with which to analyse translation, as well as providing an additional biomimetic scheme for protein analysis. Aminoacyl-tRNA synthetases microarrays could be applied to protein fingerprinting and sequence analysis. The fabrication of aminoacyl-tRNA synthetase arrays requires the use of advanced protein arraying technology that has only recently become available. In order to demonstrate the feasibility of this scheme, glutamyl-tRNA synthetase (GluRS) was immobilized on the streptavidinbased XNA on GoldTM biochip platform. The streptavidin layer provides a simple, efficient immobilization scheme that reduces nonspecific binding and improves the biocompatibility of the surface. Here, we demonstrate that biotinylated GluRS can be successfully immobilized on XNA on GoldTM. The immobilization efficiency was determined by double labelling GluRS with biotin and the fluorescent label Cy5. The CCD fluorescent microscopy images revealed that the GluRS was efficiently immobilized and evenly distributed over the surface. Control experiments indicate a very low degree of nonspecific binding which is essential if detection of these multicomponent, low-affinity interactions is to be realized. Furthermore, we show that immobilization does not significantly reduce the function of the enzyme. In addition to the specific aims of this study, this technology would provide valuable insights into the biomechanics of translation as well as being a tool for studying tRNA modifications and subclasses. Moreover, the implications for developing coupled transcription and translation systems should not be overlooked. Protein analysis schemes based on this approach would provide an urgently needed compliment to traditional methods. Finally, these arrays might also be useful tools in our efforts to understand the regulatory functions that small RNAs, i.e., iRNA, have been shown to play.
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| 33. |
- Meng, Qinglai, et al.
(författare)
-
Rapid Detection of Multiple Classes of β-Lactam Antibiotics in Blood Using an NDM-1 Biosensing Assay
- 2021
-
Ingår i: Antibiotics. - : MDPI AG. - 2079-6382. ; 10:9
-
Tidskriftsartikel (refereegranskat)abstract
- Currently, assays for rapid therapeutic drug monitoring (TDM) of β-lactam antibiotics in blood, which might be of benefit in optimizing doses for treatment of critically ill patients, remain challenging. Previously, we developed an assay for determining the penicillin-class antibiotics in blood using a thermometric penicillinase biosensor. The assay eliminates sample pretreatment, which makes it possible to perform semicontinuous penicillin determinations in blood. However, penicillinase has a narrow substrate specificity, which makes it unsuitable for detecting other classes of β-lactam antibiotics, such as cephalosporins and carbapenems. In order to assay these classes of clinically useful antibiotics, a novel biosensor was developed using New Delhi metallo-β-lactamase-1 (NDM-1) as the biological recognition layer. NDM-1 has a broad specificity range and is capable of hydrolyzing all classes of β-lactam antibiotics in high efficacy with the exception of monobactams. In this study, we demonstrated that the NDM-1 biosensor was able to quantify multiple classes of β-lactam antibiotics in blood plasma at concentrations ranging from 6.25 mg/L or 12.5 mg/L to 200 mg/L, which covered the therapeutic concentration windows of the tested antibiotics used to treat critically ill patients. The detection of ceftazidime and meropenem was not affected by the presence of the β-lactamase inhibitors avibactam and vaborbactam, respectively. Furthermore, both free and protein-bound β-lactams present in the antibiotic-spiked plasma samples were detected by the NDM-1 biosensor. These results indicated that the NDM-1 biosensor is a promising technique for rapid TDM of total β-lactam antibiotics present in the blood of critically ill patients.
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| 34. |
- Meng, Qinglai, et al.
(författare)
-
The NDM-1 biosensor rapidly and accurately detected antibiotic plasma concentrations in Cefuroxime-treated patients
- 2024
-
Ingår i: International Journal of Antimicrobial Agents. - 1872-7913. ; 64:2
-
Tidskriftsartikel (refereegranskat)abstract
- Therapeutic drug monitoring (TDM) of β-lactam antibiotics in critically ill patients may benefit dose optimization, thus improving therapeutic outcomes. However, rapidly and accurately detecting these antibiotics in blood remains a challenge. Our research group recently developed a thermometric biosensor called the New Delhi metallo-β-lactamase-1 (NDM-1) biosensor, which detected multiple classes of β-lactam antibiotics in spiked plasma samples. This study assesses the NDM-1 biosensor's effectiveness in detecting plasma concentrations of β-lactam antibiotic in treated patients. Seven patients receiving Cefuroxime were studied. Plasma samples collected pre- and post-antibiotic treatment were analyzed using the NDM-1 biosensor and compared with liquid chromatography coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The biosensor detected plasma samples without dilution, and a brief pre-treatment using a PVDF filter significantly lowered matrix effects, reducing the running time to 5-8 minutes per sample. The assay's linear range for Cefuroxime (6.25 to 200 mg/L) covered target concentrations during the trough phase of pharmacokinetics in critically ill patients. The pharmacokinetic properties of Cefuroxime in treated patients determined by the NDM-1 biosensor and the UPLC-MS/MS were comparable, and the Cefuroxime plasma concentrations measured by the two methods showed a statistically good consistency. These data demonstrate that the NDM-1 biosensor assay is a fast, sensitive, and accurate method for detecting Cefuroximeplasma concentration in treated patients and highlights the NDM-1 biosensor as a promising tool for on-site TDM of β-lactam antibiotics in critically ill patients.
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| 35. |
- Meng, Wen-Jian, et al.
(författare)
-
Correlation of SATB1 overexpression with the progression of human rectal cancer
- 2012
-
Ingår i: International Journal of Colorectal Disease. - : Springer Verlag (Germany). - 0179-1958 .- 1432-1262. ; 27:2, s. 143-150
-
Tidskriftsartikel (refereegranskat)abstract
- To date, the association between special AT-rich sequence-binding protein 1 (SATB1) and colorectal cancer (CRC) has not been reported. This study was aimed at investigating the expression and potential role of SATB1 in human rectal cancers. less thanbrgreater than less thanbrgreater thanNinety-three paired samples of rectal cancer and distant normal rectal tissue were analyzed by quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC), and the correlations between SATB1 expression and clinicopathological parameters were evaluated. The expression profiles of SATB1 were also investigated in a panel of five human colon carcinoma cell lines. less thanbrgreater than less thanbrgreater thanThe general level of SATB1 mRNA in rectal cancer tissues was statistically significantly higher than that in normal mucosa (P = 0.043). The rate of positive SATB1 protein expression in rectal cancers (44.1%) was significantly higher than that in normal tissues (25.8%) by IHC analysis (P = 0.009). Overexpression of SATB1 mRNA was more predominant in patients with earlier onset of rectal cancer (P = 0.033). SATB1 expression correlated with invasive depth and tumor node metastasis (TNM) stage at both protein and mRNA levels (P andlt; 0.05). Furthermore, SATB1 expression in the poorly metastatic KM12C cells was significantly lower than the highly metastatic KM12SM and KM12L4A cells and higher than the HCT116 and SW480 cells (P = 0.001). These results were further confirmed by Western blotting. less thanbrgreater than less thanbrgreater thanOur results indicate that SATB1 may play an important role in the progression of human rectal cancer, which represents a possible new mechanism underlying CRC.
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| 36. |
- Meng, Yuanjing, et al.
(författare)
-
High-performance SOFC based on a novel semiconductor-ionic SrFeO3-delta-Ce0.8Sm0.2O2-delta membrane
- 2018
-
Ingår i: International journal of hydrogen energy. - : Elsevier. - 0360-3199 .- 1879-3487. ; 43:28, s. 12697-12704
-
Tidskriftsartikel (refereegranskat)abstract
- The semiconductor-ionic composite membrane has been recently developed for a novel solid oxide fuel cell (SOFC), i.e., the semiconductor-ion membrane fuel cell (SIMFC). In this work, the perovskite-type SrFeO3-delta (SFO) as semiconductor material was composited with ionic conductor Ce0.8Sm0.2O2-delta (SDC) to form the SFO-SDC composite membrane for SIMFCs. The SFO-SDC SIMFCs using the optimized weight ratio of 3:7 SFO-SDC membrane obtained the best performances, 780 mW cm(-2) at 550 degrees C, compared to 348 mW cm(-2) obtained from the pure SDC electrolyte fuel cell. Introduction of SFO into SDC can extend the triple phase boundary and provide more active sites for accelerating the fuel cell reactions, thus significantly enhanced the cell power output. Moreover, SFO was employed as the cathode, and a higher power output, 907 mW cm(-2) was achieved, suggesting that SFO cathode is more compatible for the SFO-SDC system in SIMFCs. This work provides an attractive strategy for the development of low temperature SOFCs.
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| 37. |
- Meng, Yuanjing, et al.
(författare)
-
Low-temperature fuel cells using a composite of redox-stable perovskite oxide La0.7Sr0.3Cr0.5Fe0.5O3-delta and ionic conductor
- 2017
-
Ingår i: Journal of Power Sources. - : Elsevier. - 0378-7753 .- 1873-2755. ; 366, s. 259-264
-
Tidskriftsartikel (refereegranskat)abstract
- A novel solid oxide fuel cell (SOFC) incorporating the semiconductor with the ionic conductor to replace the traditional electrolyte layer with improved performance has been recently reported. In the present work, we found that the redox stable electrode material La0.7Sr0.3Cr0.5Fe0.5O3-delta(LSCrF) can be considered as a good candidate for such configuration, electrolyte layer-free fuel cells (EFFCs), due to its high ionic and electronic conductivities, excellent catalytic activity and good chemical stability. EFFCs based on the composite of perovskite oxide LSCrF and ionic conductor Ce0.8Sm0.2O2-delta (SDC) offered promising performances, i.e., 1059 mW cm(-2) at 550 degrees C without any electronic short circuiting problem. It even exhibited a highly promising result of 553 mW cm(-2) at 470 degrees C in further low-temperature operation. These high performances can be attributed to the improved conductivity, more triple-phase boundaries (TPB) and accelerated oxygen reduction reaction (ORR) of LSCrF-SDC composite. The influence of the weight ratio between LSCrF and SDC on the EFFC electrochemical performance was investigated. This new discovery indicates a great potential for exploring multifunctional perovskites for the new SOFC technologies.
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| 38. |
- Niu, Li-Ping, et al.
(författare)
-
Mechanism of fluidized chlorination reaction of Kenya natural rutile ore
- 2014
-
Ingår i: Rare Metals. - : Springer Science and Business Media LLC. - 1001-0521 .- 1867-7185. ; 33:4, s. 485-492
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, the thermodynamics and kinetics of nature rutile carbochlorination in a fluidized-bed were investigated. The thermodynamic calculations of TiO2-C-Cl-2 system show that when C is excess in the solid phase, titanium tetrachloride and carbon monoxide can exist stably. At high temperature, the reaction with CO as the product is the dominant reaction. The appropriate reaction conditions are as follows: reaction temperature of 950 A degrees C, reaction time of 40 min, carbon ratio of 30 wt% of rutile, natural rutile particle size of -96 mu m, petroleum coke size of -150 mu m, and chlorine flow of 0.036 m(3)center dot h(-1). Under the above conditions, the reaction conversion rate of TiO2 can reach about 95 %. This paper proposed a reaction rate model, and got a rutile chlorination rate formula, which is generally consistent with the experimental data. For the TiO2-C-Cl-2 system, the reaction rate is dependent on the initial radius of rutile particle, density, and the partial pressures of Cl-2. From 900 to 1,000 A degrees C, the apparent activation energy is 10.569 kJ center dot mol(-1), and the mass diffusion is found to be the main reaction-controlling step. The expression for the chlorine reaction rate in the C-Cl-2 system is obtained, and it depends on the degree of reaction, the partial pressure of Cl-2, and the size of rutile particle.
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| 39. |
- Pan, Liang, et al.
(författare)
-
a A Resistance-Switchable and Ferroelectric Metal Organic Framework
- 2014
-
Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 136:50, s. 17477-17483
-
Tidskriftsartikel (refereegranskat)abstract
- The ever-emerging demands on miniaturization of electronic devices have pushed the development of innovative materials with desired properties. One major endeavor is the development of organic- or organic-inorganic hybrid-based electronics as alternatives or supplements to silicon-based devices. Herein we report the first observation of the coexistence of resistance switching and ferroelectricity in a metal-organic framework (MOF) material, [InC16H11N2O8]center dot 1.5H(2)O, denoted as RSMOF-1. The electrical resistance of RSMOF-1 can be turned on and off repeatedly with a current ratio of 30. A first-principles molecular dynamics simulation suggests that the resistive switching effect is related to the ferroelectric transition of N center dot center dot center dot H-O center dot center dot center dot H-N bridge-structured dipoles of the guest water molecules and the amino-tethered MOF nanochannel. The discovery of the resistive switching effect and ferroelectricity in MOFs offers great potential for the physical implementation of novel electronics for next-generation digital processing and communication.
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| 40. |
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| 41. |
- Qu, Yanhua, 1974-, et al.
(författare)
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Ground tit genome reveals avian adaptation to living at high altitudes in the Tibetan plateau.
- 2013
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 4, s. 2071-
-
Tidskriftsartikel (refereegranskat)abstract
- The ground tit (Parus humilis) is endemic to the Tibetan plateau. It is a member of family Paridae but it was long thought to be related to the ground jays because of their morphological similarities. Here we present the ground tit's genome and re-sequence two tits and one ground jay, to clarify this controversially taxonomic status and uncover its genetic adaptations to the Tibetan plateau. Our results show that ground tit groups with two tits and it diverges from them between 7.7 and 9.9 Mya. Compared with other avian genomes, ground tit shows expansion in genes linked to energy metabolism and contractions in genes involved in immune and olfactory perception. We also found positively selected and rapidly evolving genes in hypoxia response and skeletal development. These results indicated that ground tit evolves basic strategies and 'tit-to-jay' change for coping with the life in an extreme environment.
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| 42. |
- Shen, Shen, et al.
(författare)
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Making multi-twisted luminophores produce persistent room-temperature phosphorescence
- 2023
-
Ingår i: Chemical Science. - : ROYAL SOC CHEMISTRY. - 2041-6520 .- 2041-6539. ; 14:4, s. 970-978
-
Tidskriftsartikel (refereegranskat)abstract
- Multi-twisted molecules, especially those with more than four branched rotation axes, have served as superior prototypes in diverse fields like molecular machines, optical materials, sensors, and so forth. However, due to excessive non-radiative relaxation of these molecules, it remains challenging to address their persistent room-temperature phosphorescence (pRTP), which limits their further development. Herein, we develop a host-guest energy-transfer relay strategy to improve the phosphorescence lifetime of multi-twisted luminophores by over thousand-fold to realize pRTP, which can be witnessed by the naked eye after removing the excitation light source. Moreover, we employ photoexcitation-induced molecular rearrangement to further prolong the phosphorescence lifetime, which, to the best of our knowledge, is the first example of photoactivation in ordered host-guest systems. Our systems show superior humidity and oxygen resistance, enabling long-term (at least over 9-12 months) stability of the pRTP properties. By achieving pRTP of multi-twisted luminophores, this work can advance the understanding of molecular photophysical mechanisms and guide the study of more molecular systems that are difficult to achieve pRTP.
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| 43. |
- Song, Chenchen, et al.
(författare)
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Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis
- 2023
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Ingår i: Frontiers in cellular and infection microbiology. - 2235-2988. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis. Here we describe the development of an assay method for activity fingerprinting of AMR β-lactamases using panels of 7 β-lactam antibiotics in 35 min. New Deli Metallo β-lactamase-1 (NDM-1) and penicillinase were demonstrated as two different classes of β-lactamases. The panel consisted of three classes of antibiotics, including: penicillins (penicillin G, piperacillin), cephalosporins (cefepime, ceftriaxone, cefazolin) and carbapenems (meropenem and imipenem). The assay employed a scheme combines the catalytic reaction of AMR β-lactamases on antibiotic substrates with a flow-injected thermometric biosensor that allows the direct detection of the heat generated from the enzymatic catalysis, and eliminates the need for custom substrates and multiple detection schemes. In order to differentiate classes of β-lactamases, characterization of the enzyme activity under different catalytic condition, such as, buffer composition, ion strength and pH were investigated. This assay could provide a tool for fast diagnosis of patient AMR status which makes possible for the future accurate treatment with selected antibiotics.
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| 44. |
- Song, Man, et al.
(författare)
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Nitrogen-doped Reduced Graphene Oxide Hydrogel Achieved via a One-Step Hydrothermal Process
- 2019
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Ingår i: ChemNanoMat. - : WILEY-V C H VERLAG GMBH. - 2199-692X. ; 5:9, s. 1144-1151
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Tidskriftsartikel (refereegranskat)abstract
- We report an efficient one-step method to achieve highly reduced graphene oxide (rGO) hydrogel doped with nitrogen where the rGO sheets are interconnected forming a porous structure by means of hydrothermal process. During the synthesis, ammonium formate is used as reducing reagent and simultaneously as nitrogen supplier, which delivers nitrogen-doped rGO (NRGO) hydrogel that exhibits C/O atomic ratio as high as at ~11.1 and contains decent ~5.4 at.% nitrogen. As comparison, the reduction efficiency is only half of the value and no nitrogen doping can be obtained when L-ascorbic acid is used as reducing reagent. The resultant NRGO shows enhanced electrocatalytic ability for oxygen reduced reaction indicating its great potential of the one-step method for the catalyst and energy applications.
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| 45. |
- Tian, Chao, et al.
(författare)
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Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients
- 2007
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Ingår i: World Journal of Gastroenterology. - 1007-9327 .- 2219-2840. ; 13:28, s. 3878-3882
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To clarify the expression change of Wnt-induced secreted protein-1 (WISP-1) in human rectal cancer and to determine whether it is correlated with invasion and metastasis of human rectal cancer. Methods: Eighty-six paired samples of rectal cancer and surgically resected distant normal rectal tissue were collected and allocated into cancer group and control group respectively. WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining. Results: WISP-1 gene overexpression was found in 65% (56/86) primary rectal cancers, 2-30 times that of the level in normal matched rectal tissues (P = 0.001). The mRNA expression level was correlated with Duke's staging, histological differentiation grade and lymph node status. The WISP-1 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in the cancer group (1.40 ± 0.35) was different from that in control group (1.04 ± 0.08, P < 0.001). Moreover, in cancer group the positive staining degree in high-level mRNA cancers (1.46 ± 0.37, n = 56) was higher than that in low-level mRNA (1.28 ± 0.28, n = 30, P = 0.018). Conclusion: Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer. © 2007 WJG. All rights reserved.
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| 46. |
- Wang, Xi, et al.
(författare)
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氨曲南竞争性抑制NDM-1对β-内酰胺类抗生素的水解
- 2019
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Ingår i: Journal of Shanxi University (Natural Science Edition). ; :2021-01
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the effect of Aztreonam on hydrolysis of β-lactam antibiotics by MBL using New Delhi Metallo-β-lactamase-1(NDM-1) as a model. The results showed that Aztreonam significantly inhibited hydrolysis of Nitrocefin and Meropenem by soluble NDM-1, but also inhibited hydrolysis of Penicillin G by CPG beads immobilized NDM-1(NDM-1 beads). Moreover, in spite of extensive washing for multiple times, the activity to hydrolyze Penicillin G by the Aztreoman pre-treated NDM-1 beads was just partially recovered. These data suggest that Aztreonam can covalently and stably bind on NDM-1, thus efficiently inhibiting hydrolysis of other kinds of β-lactam antibiotics by NDM-1 in a competitive way.
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| 47. |
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| 48. |
- Wu, Jiyue, et al.
(författare)
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Perovskite Sr-x(Bi1-xNa0.97-xLi0.03)(0.5)TiO3 ceramics with polar nano regions for high power energy storage
- 2018
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Ingår i: Nano Energy. - : ELSEVIER SCIENCE BV. - 2211-2855 .- 2211-3282. ; 50, s. 723-732
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Tidskriftsartikel (refereegranskat)abstract
- Dielectric capacitors are very attractive for high power energy storage. However, the low energy density of these capacitors, which is mainly limited by the dielectric materials, is still the bottleneck for their applications. In this work, lead-free single-phase perovskite Srx(Bi1-xNa0.97-xLi0.03)(0.5)TiO3 (x = 0.30 and 0.38) bulk ceramics, prepared using solid-state reaction method, were carefully studied for the dielectric capacitor application. Polar nano regions (PNRs) were created in this material using co-substitution at A-site to enable relaxor behaviour with low remnant polarization (P-r) and high maximum polarization (P-max). Moreover, P-max was further increased due to the electric field induced reversible phase transitions in nano regions. Comprehensive structural and electrical studies were performed to confirm the PNRs and reversible phase transitions. And finally a high energy density (1.70 J/cm(3)) with an excellent efficiency (87.2%) was achieved using the contribution of field-induced rotations of PNRs and PNR-related reversible transitions in this material, making it among the best performing lead-free dielectric ceramic bulk material for high energy storage.
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| 49. |
- Wu, Ya-ting, et al.
(författare)
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Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC
- 2014
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Ingår i: Food Chemistry. - : Elsevier BV. - 1873-7072 .- 0308-8146. ; 164, s. 527-535
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Tidskriftsartikel (refereegranskat)abstract
- Nanofibrous molecularly imprinted membranes (nano-MIMs) with multi-analyte selectivity were prepared by encapsulating two types of molecularly imprinted polymer nanoparticles (MIP-NPs) into electrospun polyvinyl alcohol nanofibers. The obtained nano-MIMs maintained high molecular selectivity offered by each of the MIP-NPs. Nano-MIM embedding BPA-imprinted nanoparticles and TBZ-imprinted nanoparticles together showed the highest binding selectivity for acid bisphenol A (BPA) and basic tebuconazole (TBZ). This nano-MIM was used as affinity material of membrane-based molecularly imprinted solid-phase extraction (m-MISPE) to extract trace BPA and TBZ in vegetables and juices simultaneously. The recoveries of BPA and TBZ from different samples were higher than 70.33% with RSDs lower than 9.57%. m-MISPE gave better HPLC separation efficiencies and higher recoveries than conventional SPE based on C18/SCX. Multi-analyte selective m-MISPE combined with HPLC realized selective and simultaneous determination of several trace analytes with opposite charges/polarities in different food samples. (C) 2014 Elsevier Ltd. All rights reserved.
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| 50. |
- Xiang, Ze, et al.
(författare)
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Comprehensive Evaluation of Anti-PD-1, Anti-PD-L1, Anti-CTLA-4 and Their Combined Immunotherapy in Clinical Trials: A Systematic Review and Meta-analysis
- 2022
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Ingår i: Frontiers in Pharmacology. - : FRONTIERS MEDIA SA. - 1663-9812. ; 13
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Forskningsöversikt (refereegranskat)abstract
- Immunotherapy with immune checkpoint inhibitor (ICI) drugs is gradually becoming a hot topic in cancer treatment. To comprehensively evaluate the safety and efficacy of ICI drugs, we employed the Bayesian model and conducted a network meta-analysis in terms of progression-free survival (PFS), overall survival (OS) and severe adverse events (AEs). Our study found that treatment with ipilimumab was significantly worse than standard therapies in terms of PFS, whereas treatment with cemiplimab significantly improved PFS. The results also indicated that cemiplimab was the best choice for PFS. Treatment with nivolumab, pembrolizumab and nivolumab plus ipilimumab significantly improved OS compared to standard therapies. In terms of OS, cemiplimab was found to be the best choice, whereas avelumab was the worst. In terms of severe AEs, atezolizumab, avelumab, durvalumab, nivolumab, and pembrolizumab all significantly reduced the risk of grade 3 or higher AEs compared to standard therapy. The least likely to be associated with severe AEs were as follows: cemiplimab, avelumab, nivolumab, atezolizumab, and camrelizumab, with nivolumab plus ipilimumab to be the worst. Therefore, different ICI drug therapies may pose different risks in terms of PFS, OS and severe AEs. Our study may provide new insights and strategies for the clinical practice of ICI drugs.
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