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| 2. |
- Acharyya, A., et al.
(författare)
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Multiwavelength Observations of the Blazar PKS 0735+178 in Spatial and Temporal Coincidence with an Astrophysical Neutrino Candidate IceCube-211208A
- 2023
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Ingår i: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 954:1
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Tidskriftsartikel (refereegranskat)abstract
- We report on multiwavelength target-of-opportunity observations of the blazar PKS 0735+178, located 2 degrees .2 away from the best -fit position of the IceCube neutrino event IceCube-211208A detected on 2021 December 8. The source was in a high -flux state in the optical, ultraviolet, X-ray, and GeV ?-ray bands around the time of the neutrino event, exhibiting daily variability in the soft X-ray flux. The X-ray data from Swift-XRT and NuSTAR characterize the transition between the low-energy and high-energy components of the broadband spectral energy distribution (SED), and the ?-ray data from Fermi-LAT, VERITAS, and H.E.S.S. require a spectral cutoff near 100 GeV. Both the X-ray and ?-ray measurements provide strong constraints on the leptonic and hadronic models. We analytically explore a synchrotron self-Compton model, an external Compton model, and a lepto-hadronic model. Models that are entirely based on internal photon fields face serious difficulties in matching the observed SED. The existence of an external photon field in the source would instead explain the observed ?-ray spectral cutoff in both the leptonic and lepto-hadronic models and allow a proton jet power that marginally agrees with the Eddington limit in the lepto-hadronic model. We show a numerical lepto-hadronic model with external target photons that reproduces the observed SED and is reasonably consistent with the neutrino event despite requiring a high jet power.
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| 7. |
- Chijimatsu, M., et al.
(författare)
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Numerical study of the THM effects on the near-field safety of a hypothetical nuclear waste repository - BMT1 of the DECOVALEX III project. Part 1 : Conceptualization and characterization of the problems and summary of results
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 720-730
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Tidskriftsartikel (refereegranskat)abstract
- Geological disposal of the spent nuclear fuel often uses the concept of multiple barrier systems. In order to predict the performance of these barriers, mathematical models have been developed, verified and validated against analytical solutions, laboratory tests and field experiments within the international DECOVALEX III project. These models in general consider the full coupling of thermal (T), hydraulic (H) and mechanical (M) processes that would prevail in the geological media around the repository. For Bench Mark Test no. 1 (BMTI) of the DECOVALEX III project, seven multinational research teams studied the implications of coupled THM processes on the safety of a hypothetical nuclear waste repository at the near-field and are presented in three accompanying papers in this issue. This paper is the first of the three companion papers, which provides the conceptualization and characterization of the BMT1 as well as some general conclusions based on the findings of the numerical studies. It also shows the process of building confidence in the mathematical models by calibration with a reference T-H-M experiment with realistic rock mass conditions and bentonite properties and measured outputs of thermal, hydraulic and mechanical variables.
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| 8. |
- Khandelwal, Pooja, et al.
(författare)
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Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States : A Center for International Blood and Marrow Transplant Research Report
- 2017
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 23:8, s. 1342-1349
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Tidskriftsartikel (refereegranskat)abstract
- This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric patients with cancer, 4408 undergoing allogeneic (allo) and3076 undergoing autologous (auto) HSCT in the United States between 2008 and 2014. In both settings, there was a greater proportion of boys (n = 4327; 57%), children < 10 years of age (n = 4412; 59%), whites (n = 5787; 77%), and children with a performance score 90% at HSCT (n = 6187; 83%). Leukemia was the most common indication for an allo-transplant (n = 4170; 94%), and among these, acute lymphoblastic leukemia in second complete remission (n = 829; 20%) and acute myeloid leukemia in first complete remission (n = 800; 19%) were the most common. The most frequently used donor relation, stem cell sources, and HLA match were unrelated donor (n = 2933; 67%), bone marrow (n = 2378; 54%), and matched at 8/8 HLA antigens (n = 1098; 37%) respectively. Most allo-transplants used myeloablative conditioning (n = 4070; 92%) and calcineurin inhibitors and methotrexate (n = 2245; 51%) for acute graft-versus-host disease prophylaxis. Neuroblastoma was the most common primary neoplasm for an auto-transplant (n = 1338; 44%). Tandem auto-transplants for neuroblastoma declined after 2012 (40% in 2011, 25% in 2012, and 8% in 2014), whereas tandem auto transplants increased for brain tumors (57% in 2008 and 77% in 2014). Allo-transplants from relatives other than HLA-identical siblings doubled between 2008 and 2014 (3% in 2008 and 6% in 2014). These trends will be monitored in future reports of transplant practices in the United States.
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| 9. |
- Millard, A., et al.
(författare)
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Evaluation of Thm Coupling on the Safety Assessment of a Nuclear Fuel Waste Repository in a Homogeneous Hard Rock
- 2004
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Ingår i: Coupled Thermo-Hydro-Mechanical-Chemical Processes in Geo-Systems — Fundamentals, Modelling, Experiments and Applications. - : Elsevier. ; , s. 211-216
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Bokkapitel (refereegranskat)abstract
- An evaluation of the importance of the thermo-hydro-mechanical couplings (THM) on the performance assessment of a deep underground storage design has been made as part of the international DECOVALEX III project. It is a numerical study that simulates a generic repository configuration in the near field in a homogeneous hard rock. A periodic pattern comprises a single vertical borehole, containing a canister surrounded by an over-pack and a bentonite layer, and the backfilled upper portion of the gallery. The thermo-hydro-mechanical evolution of the whole configuration is simulated over a period of 100 years. The importance of the rock mass intrinsic permeability has been investigated through three values : 10 -17, 10 -18 and 10 -19 m 2. Comparison of the results predicted by fully coupled THM analysis as well as partially coupled TH, TM and HM analysis, in terms of several predefined indicators, enables us to identify the couplings, which play a crucial role with respect to safety issues. The results demonstrate that temperature is hardly affected by the couplings. In contrast the influence of the couplings on the mechanical stresses is considerable.
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| 10. |
- Millard, A., et al.
(författare)
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Numerical study of the THM effects on the near-field safety of a hypothetical nuclear waste repository - BMT1 of the DECOVALEX III project. Part 2 : Effects of THM coupling in continuous and homogeneous rocks
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 731-744
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Tidskriftsartikel (refereegranskat)abstract
- An evaluation of the importance of the thermo-hydro-mechanical couplings (THM) on the performance assessment of a deep underground radioactive waste repository has been made as a part of the international DECOVALEX III project. It is a numerical study that simulates a generic repository configuration in the near field in a continuous and homogeneous hard rock. A periodic repository configuration comprises a single vertical borehole, containing a canister surrounded by an over-pack and a bentonite layer, and the backfilled upper portion of the gallery. The thermo-hydro-mechanical evolution of the whole configuration is simulated over a period of 100 years. The importance of the rock mass's intrinsic permeability has been investigated through scoping calculations with three values: 10(-17), 10(-18) and 10(-19) m(2). Comparison of the results predicted by fully coupled THM analysis as well as partially coupled TH, TM and HM analyses, in terms of several predefined indicators of importance for performance assessment, enables us to identify the effects of the different combinations of couplings, which play a crucial role with respect to safety issues. The results demonstrate that temperature is hardly affected by the couplings. In contrast, the influence of the couplings on the mechanical stresses is considerable.
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| 11. |
- Nguyen, T. S., et al.
(författare)
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Implications of Coupled Thermo-Hydro-Mechanical Processes on the Safety of a Hypothetical Nuclear Fuel Waste Repository
- 2004
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Ingår i: Coupled Thermo-Hydro-Mechanical-Chemical Processes in Geo-Systems — Fundamentals, Modelling, Experiments and Applications. - : Elsevier. ; , s. 225-230
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Bokkapitel (refereegranskat)abstract
- In Bench Mark Test no. 1 (BMT1) of the DECOVALEX III international project, we looked at the implications of coupled thermo-hydro-mechanical (THM) processes on the safety of a hypothetical nuclear waste repository. The research teams first calibrated their models with the results of an in-situ heater experiments to obtain confidence in the capability of the models to simulate the main physical processes. Then the models were used to perform scoping calculations for the near-field of the hypothetical repository, with varying degrees of THM coupling complexity. The general conclusion from the BMT1 exercise is that it would be prudent to perform full THM coupling analyses for two main reasons. First, several safety features might be overlooked with lesser degrees of coupling. Second, the ability to predict and interpret several physical processes, during the post-closure monitoring period, is important for confidence building and public acceptance. Such ability is attainable only with fully coupled THM models.
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| 12. |
- Myers, Regina M., et al.
(författare)
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Long-Term Outcomes Among 2-Year Survivors of Autologous Hematopoietic Cell Transplantation for Hodgkin and Diffuse Large B-Cell Lymphoma
- 2018
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Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 124:4, s. 816-825
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Autologous hematopoietic cell transplantation (auto-HCT) is a standard therapy for relapsed classic Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL); however, long-term outcomes are not well described.METHODS: This study analyzed survival, nonrelapse mortality, late effects, and subsequent malignant neoplasms (SMNs) in 1617 patients who survived progression-free for >= 2 years after auto-HCT for cHL or DLBCL between 1990 and 2008. The median age at auto-HCT was 40 years; the median follow-up was 10.6 years.RESULTS: The 5-year overall survival rate was 90% (95% confidence interval [CI], 87%-92%) for patients with cHL and 89% (95% CI, 87%-91%) for patients with DLBCL. The risk of late mortality in comparison with the general population was 9.6-fold higher for patients with cHL (standardized mortality ratio [SMR], 9.6) and 3.4-fold higher for patients with DLBCL (SMR, 3.4). Relapse accounted for 44% of late deaths. At least 1 late effect was reported for 9% of the patients. A total of 105 SMNs were confirmed: 44 in the cHL group and 61 in the DLBCL group. According to a multivariate analysis, older age, male sex, a Karnofsky score < 90, total body irradiation (TBI) exposure, and a higher number of lines of chemotherapy before auto-HCT were risk factors for overall mortality in cHL. Risk factors in DLBCL were older age and TBI exposure. A subanalysis of 798 adolescent and young adult patients mirrored the outcomes of the overall study population.CONCLUSIONS: Despite generally favorable outcomes, 2-year survivors of auto-HCT for cHL or DLBCL have an excess late-mortality risk in comparison with the general population and experience an assortment of late complications.
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| 14. |
- Crassous, Jerome J., et al.
(författare)
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Asymmetric self-assembly of oppositely charged composite microgels and gold nanoparticles
- 2012
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Ingår i: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-6848 .- 1744-683X. ; 8:5, s. 1648-1656
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Tidskriftsartikel (refereegranskat)abstract
- The electrostatically driven self-assembly of oppositely charged gold nanoparticles (Au NPs) and polystyrene/poly(N-isopropylacrylamide) (PS/PNIPAm) core-shell microgels (CSMs) has been investigated. The co-assembly was accomplished by addition of smaller Au NPs to CSMs in dilute conditions up to a number ratio of about 1 : 1, when the suspension is destabilized. A combination of different techniques (i.e. turbidimetric titration, electrophoretic mobility, UV-visible spectroscopy, dynamic light scattering and microscopy techniques) were used to investigate the association between the two particles and the stability of the different mixtures. Hereby we demonstrate that the size ratio between the two particles (about 4 to 1) and the asymmetric character of the association result in the formation of electrostatic hybrid complexes, analogous to dipolar colloidal molecules, which further rearrange into finite sized clusters for number ratios N(AuNPs)/N(CSMs) < 1.
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| 17. |
- Rutqvist, J., et al.
(författare)
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A numerical study of THM effects on the near-field safety of a hypothetical nuclear waste repository - BMT1 of the DECOVALEX III project. Part 3 : Effects of THM coupling in sparsely fractured rocks
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 745-755
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Tidskriftsartikel (refereegranskat)abstract
- As a part of the international DECOVALEX III project, and the European BENCHPAR project, the impact of thermal-hydrological-mechanical (THM) couplings on the performance of a bentonite-back-filled nuclear waste repository in near-field crystalline rocks is evaluated in a Bench-Mark Test problem (BMT1) and the results are presented in a series of three companion papers in this issue. This is the third paper with focuses on the effects of THM processes at a repository located in a sparsely fractured rock. Several independent coupled THM analyses presented in this paper show that THM couplings have the most significant impact on the mechanical stress evolution, which is important for repository design, construction and post-closure monitoring considerations. The results show that the stress evolution in the bentonite-back-filled excavations and the surrounding rock depends on the post-closure evolution of both fields of temperature and fluid pressure. It is further shown that the time required to full resaturation may play an important role for the mechanical integrity of the repository drifts. In this sense, the presence of hydraulically conducting fractures in the near-field rock might actually improve the mechanical performance of the repository. Hydraulically conducting fractures in the near-field rocks enhances the water supply to the buffers/back-fills, which promotes a more timely process of resaturation and development of swelling pressures in the back-fill, thus provides timely confining stress and support to the rock walls. In one particular case simulated in this study, it was shown that failure in the drift walls could be prevented if the compressive stresses in back-fill were fully developed within 50 yr, which is when thermally induced rock strain begins to create high differential (failure-prone) stresses in the near-field rocks. Published by Elsevier Ltd.
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