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- Burstein, R., et al.
(författare)
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Mapping 123 million neonatal, infant and child deaths between 2000 and 2017
- 2019
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 574:7778, s. 353-358
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Tidskriftsartikel (refereegranskat)abstract
- Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations. © 2019, The Author(s).
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| 3. |
- Charette, M, et al.
(författare)
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Coastal ocean and shelf-sea biogeochemical cycling of trace elements and isotopes: lessons learned from GEOTRACES
- 2016
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Ingår i: Philosopical Transactions of the Royal Society A. - : The Royal Society. - 1364-503X. ; 374:2081
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Forskningsöversikt (refereegranskat)abstract
- Continental shelves and shelf seas play a central role in the global carbon cycle. However,their importance with respect to trace element and isotope (TEI) inputs to ocean basinsis less well understood. Here, we present major findings on shelf TEI biogeochemistryfrom the GEOTRACES programme as well as a proof of concept for a new method toestimate shelf TEI fluxes. The case studies focus on advances in our understanding of TEIcycling in the Arctic, transformations within a major river estuary (Amazon), shelf sedimentmicronutrient fluxes and basin-scale estimates of submarine groundwater discharge. Theproposed shelf flux tracer is 228-radium (T1/2 =5.75 yr), which is continuously supplied tothe shelf from coastal aquifers, sediment porewater exchange and rivers. Model-derived shelf228Ra fluxes are combined with TEI/ 228Ra ratios to quantify ocean TEI fluxes from thewestern North Atlantic margin. The results from this new approach agree well with previousestimates for shelf Co, Fe, Mn and Zn inputs and exceed published estimates of atmosphericdeposition by factors of approximately 3–23. Lastly, recommendations are made for additionalGEOTRACES process studies and coastal margin-focused section cruises that will help refinethe model and provide better insight on the mechanisms driving shelf-derived TEI fluxesto the ocean.This article is part of the themed issue ‘Biological and climatic impacts of ocean trace elementchemistry’.
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| 4. |
- Ederle, Joerg, et al.
(författare)
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Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
- 2010
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Ingår i: The Lancet. - 1474-547X. ; 375:9719, s. 985-997
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Tidskriftsartikel (refereegranskat)abstract
- Background Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Findings The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4.0%) events of disabling stroke or death in the stenting group compared with 27 (3.2%) events in the endarterectomy group (hazard ratio [HR] 1.28, 95% CI 0.77-2.11). The incidence of stroke, death, or procedural myocardial infarction was 8.5% in the stenting group compared with 5.2% in the endarterectomy group (72 vs 44 events; HR 1.69, 1.16-2.45, p=0.006), Risks of any stroke (65 vs 35 events; HR 1.92, 1.27-2.89) and all-cause death (19 vs seven events; HR 2.76, 1.16-6.56) were higher in the stenting group than in the endarterectomy group. Three procedural myocardial infarctions were recorded in the stenting group, all of which were fatal, compared with four, all non-fatal, in the endarterectomy group. There was one event of cranial nerve palsy in the stenting group compared with 45 in the endarterectomy group. There were also fewer haematomas of any severity in the stenting group than in the endarterectomy group (31 vs 50 events; p=0.0197). Interpretation Completion of long-term follow-up is needed to establish the efficacy of carotid artery stenting compared with endarterectomy. In the meantime, carotid endarterectomy should remain the treatment of choice for patients suitable for surgery.
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| 5. |
- Hsiao, E. Y., et al.
(författare)
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Strong near-infrared carbon in the Type Ia supernova iPTF13ebh
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 578
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Tidskriftsartikel (refereegranskat)abstract
- We present near-infrared (NIR) time-series spectroscopy, as well as complementary ultraviolet (UV), optical, and NIR data, of the Type Ia supernova (SN Ia) iPTF13ebh, which was discovered within two days from the estimated time of explosion. The first NIR spectrum was taken merely 2 : 3 days after explosion and may be the earliest NIR spectrum yet obtained of a SN Ia. The most striking features in the spectrum are several NIR C I lines, and the C I lambda 1.0693 mu m line is the strongest ever observed in a SN Ia. Interestingly, no strong optical C II counterparts were found, even though the optical spectroscopic time series began early and is densely cadenced. Except at the very early epochs, within a few days from the time of explosion, we show that the strong NIR C I compared to the weaker optical C II appears to be general in SNe Ia. iPTF13ebh is a fast decliner with Delta m(15)(B) = 1.79 +/- 0.01, and its absolute magnitude obeys the linear part of the width-luminosity relation. It is therefore categorized as a transitional event, on the fast-declining end of normal SNe Ia as opposed to subluminous/91bg-like objects. iPTF13ebh shows NIR spectroscopic properties that are distinct from both the normal and subluminous/91bg-like classes, bridging the observed characteristics of the two classes. These NIR observations suggest that composition and density of the inner core are similar to that of 91bg-like events, and that it has a deep-reaching carbon burning layer that is not observed in more slowly declining SNe Ia. There is also a substantial difference between the explosion times inferred from the early-time light curve and the velocity evolution of the Si II lambda 0.6355 mu m line, implying a long dark phase of similar to 4 days.
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| 6. |
- Milne, G.A., et al.
(författare)
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Continuous GPS measurements of postglacial adjustment in Fennoscandia: 2. Modeling results
- 2004
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 109:B2
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Tidskriftsartikel (refereegranskat)abstract
- [1] Data collected under the auspices of the BIFROST GPS project yield a geographically dense suite of estimates of present-day, three-dimensional (3-D) crustal deformation rates in Fennoscandia [Johansson et al., 2002]. A preliminary forward analysis of these estimates [Milne et al., 2001] has indicated that models of ongoing glacial isostatic adjustment (GIA) in response to the final deglaciation event of the current ice age are able to provide an excellent fit to the observed 3-D velocity field. In this study we revisit our previous GIA analysis by considering a more extensive suite of forward calculations and by performing the first formal joint inversion of the BIFROST rate estimates. To establish insight into the physics of the GIA response in the region, we begin by decomposing a forward prediction into the three contributions associated with the ice, ocean, and rotational forcings. From this analysis we demonstrate that recent advances in postglacial sea level theory, in particular the inclusion of rotational effects and improvements in the treatment of the ocean load in the vicinity of an evolving continental margin, involve peak signals that are larger than the observational uncertainties in the BIFROST network. The forward analysis is completed by presenting predictions for a pair of Fennoscandian ice histories and an extensive suite of viscoelastic Earth models. The former indicates that the BIFROST data set provides a powerful discriminant of such histories. The latter yields bounds on the ( assumed constant) upper and lower mantle viscosity (nu(UM), nu(LM)); specifically, we derive a 95% confidence interval of 5 x 10(20) less than or equal to nu(UM) less than or equal to 10(21) Pa s and 5 x 10(21) less than or equal to nu(LM) less than or equal to 5 x 10(22) Pa s, with some preference for (elastic) lithospheric thickness in excess of 100 km. The main goal of the ( Bayesian) inverse analysis is to estimate the radial resolving power of the BIFROST GPS data as a function of depth in the mantle. Assuming a reasonably accurate ice history, we demonstrate that this resolving power varies from similar to 200 km near the base of the upper mantle to similar to 700 km in the top portion of the lower mantle. We conclude that the BIFROST data are able to resolve structure on radial length scale significantly smaller than a single upper mantle layer. However, these data provide little constraint on viscosity in the bottom half of the mantle. Finally, elements of both the forward and inverse analyses indicate that radial and horizontal velocity estimates provide distinct constraints on mantle viscosity.
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